ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.30323910
2	ribosomal small subunit biogenesis (GO:0042274)	8.23324614
3	translational termination (GO:0006415)	7.94851906
4	maturation of SSU-rRNA (GO:0030490)	7.29607864
5	ribosomal small subunit assembly (GO:0000028)	7.09601542
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.75687745
7	translational elongation (GO:0006414)	6.68949923
8	cotranslational protein targeting to membrane (GO:0006613)	6.66528199
9	protein targeting to ER (GO:0045047)	6.60475368
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.30932847
11	protein localization to endoplasmic reticulum (GO:0070972)	6.17632659
12	cellular protein complex disassembly (GO:0043624)	6.07169664
13	viral life cycle (GO:0019058)	5.93017004
14	ribosomal large subunit biogenesis (GO:0042273)	5.88786126
15	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.74231944
16	ATP synthesis coupled proton transport (GO:0015986)	5.32702981
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.32702981
18	protein complex disassembly (GO:0043241)	5.12810950
19	translational initiation (GO:0006413)	5.10169986
20	chaperone-mediated protein transport (GO:0072321)	5.06536779
21	protein neddylation (GO:0045116)	4.90425924
22	macromolecular complex disassembly (GO:0032984)	4.83570926
23	behavioral response to nicotine (GO:0035095)	4.79493331
24	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.55924792
25	ribonucleoprotein complex biogenesis (GO:0022613)	4.55753926
26	translation (GO:0006412)	4.30618130
27	protein targeting to membrane (GO:0006612)	4.30326327
28	cellular component biogenesis (GO:0044085)	4.18326715
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.17562783
30	NADH dehydrogenase complex assembly (GO:0010257)	4.17562783
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.17562783
32	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.14969079
33	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.08319585
34	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.00862978
35	protein complex biogenesis (GO:0070271)	3.98436964
36	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.96508620
37	mRNA catabolic process (GO:0006402)	3.87332267
38	pyrimidine nucleotide catabolic process (GO:0006244)	3.64262418
39	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.63611696
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.63502391
41	respiratory electron transport chain (GO:0022904)	3.60816923
42	electron transport chain (GO:0022900)	3.58612430
43	RNA catabolic process (GO:0006401)	3.57022692
44	water-soluble vitamin biosynthetic process (GO:0042364)	3.54384666
45	segment specification (GO:0007379)	3.46387323
46	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.29722957
47	cell proliferation in forebrain (GO:0021846)	3.28336677
48	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.27645893
49	axonemal dynein complex assembly (GO:0070286)	3.23686715
50	hypothalamus development (GO:0021854)	3.22964707
51	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.21302481
52	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.21302481
53	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.17675068
54	substrate-independent telencephalic tangential migration (GO:0021826)	3.17675068
55	ubiquinone biosynthetic process (GO:0006744)	3.17553473
56	rRNA metabolic process (GO:0016072)	3.15218230
57	rRNA processing (GO:0006364)	3.15208760
58	ATP biosynthetic process (GO:0006754)	3.12152970
59	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.11747375
60	ncRNA catabolic process (GO:0034661)	3.10950945
61	GTP biosynthetic process (GO:0006183)	3.10462992
62	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.10101914
63	nonmotile primary cilium assembly (GO:0035058)	3.05658238
64	protein polyglutamylation (GO:0018095)	3.02013300
65	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.96897785
66	protein targeting (GO:0006605)	2.96518039
67	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.92434027
68	ubiquinone metabolic process (GO:0006743)	2.90347398
69	pattern specification involved in kidney development (GO:0061004)	2.89754462
70	neuron fate determination (GO:0048664)	2.88221212
71	establishment of protein localization to membrane (GO:0090150)	2.87982299
72	peptidyl-histidine modification (GO:0018202)	2.87335291
73	regulation of cilium movement (GO:0003352)	2.85026555
74	rRNA catabolic process (GO:0016075)	2.83832270
75	respiratory chain complex IV assembly (GO:0008535)	2.81308079
76	establishment of protein localization to organelle (GO:0072594)	2.81218561
77	ribosome biogenesis (GO:0042254)	2.81052362
78	epithelial cilium movement (GO:0003351)	2.79088504
79	negative regulation of T cell differentiation in thymus (GO:0033085)	2.78034615
80	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.77683396
81	hydrogen ion transmembrane transport (GO:1902600)	2.77676018
82	DNA deamination (GO:0045006)	2.75398381
83	auditory receptor cell differentiation (GO:0042491)	2.70543875
84	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.70398618
85	termination of RNA polymerase III transcription (GO:0006386)	2.70398618
86	somite development (GO:0061053)	2.67432132
87	base-excision repair, AP site formation (GO:0006285)	2.66022272
88	cardiovascular system development (GO:0072358)	2.65964328
89	UTP metabolic process (GO:0046051)	2.65775916
90	nephron epithelium morphogenesis (GO:0072088)	2.63977562
91	nephron tubule morphogenesis (GO:0072078)	2.63977562
92	UTP biosynthetic process (GO:0006228)	2.62548352
93	parturition (GO:0007567)	2.61383194
94	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.59585343
95	intraciliary transport (GO:0042073)	2.59002251
96	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.58649862
97	rRNA modification (GO:0000154)	2.57472319
98	motile cilium assembly (GO:0044458)	2.55167374
99	proton transport (GO:0015992)	2.54333169
100	cytochrome complex assembly (GO:0017004)	2.53647675

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.41256349
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.26700116
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.64971321
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.48282160
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.82397302
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.55938658
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.50816516
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.50495311
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.48130010
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.34674574
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.18161545
12	VDR_22108803_ChIP-Seq_LS180_Human	2.16469338
13	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.00471691
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89108836
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.88091692
16	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.85217996
17	TTF2_22483619_ChIP-Seq_HELA_Human	1.82296174
18	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.80272041
19	IRF1_19129219_ChIP-ChIP_H3396_Human	1.73585900
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69799742
21	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.69619974
22	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.65658219
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.62380977
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.58011341
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.57779993
26	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.55839850
27	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.55157719
28	XRN2_22483619_ChIP-Seq_HELA_Human	1.54371806
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.54332392
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.52732255
31	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.52584814
32	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.51733559
33	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.50140916
34	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.50033735
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.48735097
36	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.44720644
37	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.44651886
38	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.42501841
39	GABP_19822575_ChIP-Seq_HepG2_Human	1.41299697
40	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.40099505
41	TAF2_19829295_ChIP-Seq_ESCs_Human	1.39556110
42	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.37222630
43	FUS_26573619_Chip-Seq_HEK293_Human	1.36395480
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.35998056
45	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.31746210
46	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.31361681
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.31358195
48	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.31265808
49	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.28368167
50	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28259928
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27582897
52	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.27357209
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26708844
54	NANOG_20526341_ChIP-Seq_ESCs_Human	1.25368841
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24624965
56	ERA_21632823_ChIP-Seq_H3396_Human	1.24493339
57	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.23759237
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23549655
59	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.23172868
60	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.23106820
61	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.23106820
62	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.22226569
63	ELK1_19687146_ChIP-ChIP_HELA_Human	1.21025721
64	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19791188
65	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.18731766
66	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.17320890
67	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.17230547
68	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.16747204
69	EWS_26573619_Chip-Seq_HEK293_Human	1.15837692
70	NCOR_22424771_ChIP-Seq_293T_Human	1.15720197
71	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.14615263
72	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.14068322
73	MYC_19829295_ChIP-Seq_ESCs_Human	1.12666256
74	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.12140014
75	REST_21632747_ChIP-Seq_MESCs_Mouse	1.09548434
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.09125877
77	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.08878513
78	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.05501232
79	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.05298562
80	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.05262653
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04415027
82	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.04282936
83	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.03998285
84	P53_21459846_ChIP-Seq_SAOS-2_Human	1.03940172
85	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.03697999
86	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.01793455
87	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00810314
88	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00810314
89	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.98816764
90	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.98141985
91	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.97983912
92	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.97458859
93	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.97445536
94	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.95420008
95	CTCF_20526341_ChIP-Seq_ESCs_Human	0.93574694
96	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92942866
97	AR_20517297_ChIP-Seq_VCAP_Human	0.92262018
98	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.91710900
99	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.90489254
100	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.90436157

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.77156684
2	MP0006292_abnormal_olfactory_placode	4.16130578
3	MP0003122_maternal_imprinting	2.88270376
4	MP0002837_dystrophic_cardiac_calcinosis	2.83535894
5	MP0003787_abnormal_imprinting	2.59274943
6	MP0003123_paternal_imprinting	2.58274457
7	MP0008877_abnormal_DNA_methylation	2.44459093
8	MP0002163_abnormal_gland_morphology	2.40774707
9	MP0004142_abnormal_muscle_tone	2.32142431
10	MP0003646_muscle_fatigue	2.19188392
11	MP0001293_anophthalmia	2.16865866
12	MP0001348_abnormal_lacrimal_gland	2.11611581
13	MP0005379_endocrine/exocrine_gland_phen	2.01925429
14	MP0005377_hearing/vestibular/ear_phenot	1.91666448
15	MP0003878_abnormal_ear_physiology	1.91666448
16	MP0003121_genomic_imprinting	1.84884777
17	MP0008789_abnormal_olfactory_epithelium	1.81911491
18	MP0005646_abnormal_pituitary_gland	1.81291679
19	MP0002653_abnormal_ependyma_morphology	1.79604670
20	MP0003011_delayed_dark_adaptation	1.74726668
21	MP0001485_abnormal_pinna_reflex	1.67608451
22	MP0000049_abnormal_middle_ear	1.67046502
23	MP0002876_abnormal_thyroid_physiology	1.65471439
24	MP0006276_abnormal_autonomic_nervous	1.59431648
25	MP0002160_abnormal_reproductive_system	1.52675554
26	MP0003136_yellow_coat_color	1.49418878
27	MP0000778_abnormal_nervous_system	1.49366396
28	MP0004885_abnormal_endolymph	1.44813628
29	MP0008872_abnormal_physiological_respon	1.44723457
30	MP0002938_white_spotting	1.44709111
31	MP0005394_taste/olfaction_phenotype	1.44515801
32	MP0005499_abnormal_olfactory_system	1.44515801
33	MP0001986_abnormal_taste_sensitivity	1.41397340
34	MP0002638_abnormal_pupillary_reflex	1.37279252
35	MP0002272_abnormal_nervous_system	1.34728700
36	MP0005551_abnormal_eye_electrophysiolog	1.32713894
37	MP0002736_abnormal_nociception_after	1.31923603
38	MP0003880_abnormal_central_pattern	1.31711146
39	MP0001984_abnormal_olfaction	1.31654443
40	MP0001440_abnormal_grooming_behavior	1.27978584
41	MP0000631_abnormal_neuroendocrine_gland	1.27938085
42	MP0002102_abnormal_ear_morphology	1.26277235
43	MP0005389_reproductive_system_phenotype	1.23154524
44	MP0009046_muscle_twitch	1.21410485
45	MP0000372_irregular_coat_pigmentation	1.21329444
46	MP0005423_abnormal_somatic_nervous	1.21024558
47	MP0001968_abnormal_touch/_nociception	1.20667767
48	MP0005195_abnormal_posterior_eye	1.19006897
49	MP0006072_abnormal_retinal_apoptosis	1.17083725
50	MP0003937_abnormal_limbs/digits/tail_de	1.16134689
51	MP0004742_abnormal_vestibular_system	1.16007575
52	MP0003186_abnormal_redox_activity	1.10904018
53	MP0001529_abnormal_vocalization	1.10903231
54	MP0009053_abnormal_anal_canal	1.10694210
55	MP0009745_abnormal_behavioral_response	1.10290871
56	MP0001502_abnormal_circadian_rhythm	1.08215957
57	MP0003693_abnormal_embryo_hatching	1.07999965
58	MP0001905_abnormal_dopamine_level	1.06799103
59	MP0005084_abnormal_gallbladder_morpholo	1.05795314
60	MP0003879_abnormal_hair_cell	1.05495601
61	MP0003195_calcinosis	1.03917797
62	MP0002277_abnormal_respiratory_mucosa	1.03876853
63	MP0000026_abnormal_inner_ear	1.03181364
64	MP0008775_abnormal_heart_ventricle	1.02513707
65	MP0000955_abnormal_spinal_cord	1.01964804
66	MP0002752_abnormal_somatic_nervous	1.00854942
67	MP0004133_heterotaxia	1.00811855
68	MP0002557_abnormal_social/conspecific_i	1.00169572
69	MP0001486_abnormal_startle_reflex	0.99073079
70	MP0002572_abnormal_emotion/affect_behav	0.97120649
71	MP0003942_abnormal_urinary_system	0.96896765
72	MP0002249_abnormal_larynx_morphology	0.95788935
73	MP0002184_abnormal_innervation	0.95216129
74	MP0005257_abnormal_intraocular_pressure	0.94796504
75	MP0005410_abnormal_fertilization	0.93088965
76	MP0004145_abnormal_muscle_electrophysio	0.93042220
77	MP0006036_abnormal_mitochondrial_physio	0.93016868
78	MP0001963_abnormal_hearing_physiology	0.92588891
79	MP0001919_abnormal_reproductive_system	0.92422208
80	MP0003938_abnormal_ear_development	0.89769817
81	MP0009250_abnormal_appendicular_skeleto	0.89527125
82	MP0001286_abnormal_eye_development	0.87894918
83	MP0005253_abnormal_eye_physiology	0.87871899
84	MP0001970_abnormal_pain_threshold	0.84670545
85	MP0002210_abnormal_sex_determination	0.84407744
86	MP0005174_abnormal_tail_pigmentation	0.82530269
87	MP0001188_hyperpigmentation	0.82172357
88	MP0002095_abnormal_skin_pigmentation	0.82022728
89	MP0002234_abnormal_pharynx_morphology	0.81115350
90	MP0005391_vision/eye_phenotype	0.80588391
91	MP0003567_abnormal_fetal_cardiomyocyte	0.80275979
92	MP0005645_abnormal_hypothalamus_physiol	0.80262370
93	MP0010030_abnormal_orbit_morphology	0.77383192
94	MP0008875_abnormal_xenobiotic_pharmacok	0.76606662
95	MP0003786_premature_aging	0.75859539
96	MP0002067_abnormal_sensory_capabilities	0.75254982
97	MP0002138_abnormal_hepatobiliary_system	0.74679030
98	MP0002733_abnormal_thermal_nociception	0.74374012
99	MP0002064_seizures	0.74113139
100	MP0000230_abnormal_systemic_arterial	0.72110913

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.05032233
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.23858502
3	Acute necrotizing encephalopathy (HP:0006965)	4.12238519
4	Macrocytic anemia (HP:0001972)	4.08583150
5	Acute encephalopathy (HP:0006846)	3.66801538
6	Abnormality of midbrain morphology (HP:0002418)	3.65127970
7	Molar tooth sign on MRI (HP:0002419)	3.65127970
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.62656647
9	Mitochondrial inheritance (HP:0001427)	3.26505833
10	Progressive macrocephaly (HP:0004481)	3.26460865
11	Congenital stationary night blindness (HP:0007642)	3.19660723
12	Pancreatic fibrosis (HP:0100732)	3.09028631
13	3-Methylglutaconic aciduria (HP:0003535)	3.05939468
14	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.04732157
15	Pallor (HP:0000980)	2.99810942
16	Abnormal number of erythroid precursors (HP:0012131)	2.95055954
17	Increased CSF lactate (HP:0002490)	2.94599500
18	Septo-optic dysplasia (HP:0100842)	2.90994149
19	Anophthalmia (HP:0000528)	2.83595618
20	Stenosis of the external auditory canal (HP:0000402)	2.77444777
21	Medial flaring of the eyebrow (HP:0010747)	2.70420962
22	Absent/shortened dynein arms (HP:0200106)	2.69762113
23	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.69762113
24	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.68508328
25	Hepatocellular necrosis (HP:0001404)	2.67053758
26	Pancreatic cysts (HP:0001737)	2.66761085
27	Absent thumb (HP:0009777)	2.66317668
28	Chronic hepatic failure (HP:0100626)	2.64239347
29	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.61333263
30	Cerebral edema (HP:0002181)	2.58776739
31	Abnormal ciliary motility (HP:0012262)	2.57973767
32	Asplenia (HP:0001746)	2.51201955
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.49488626
34	Abnormality of the renal cortex (HP:0011035)	2.44266381
35	Hepatic necrosis (HP:0002605)	2.43986955
36	Type II lissencephaly (HP:0007260)	2.39876973
37	Nephronophthisis (HP:0000090)	2.37652903
38	Sclerocornea (HP:0000647)	2.36858011
39	Abnormal respiratory motile cilium morphology (HP:0005938)	2.35698082
40	Abnormal respiratory epithelium morphology (HP:0012253)	2.35698082
41	Pendular nystagmus (HP:0012043)	2.31063035
42	Maternal diabetes (HP:0009800)	2.30864519
43	Abnormal respiratory motile cilium physiology (HP:0012261)	2.30027298
44	Optic disc pallor (HP:0000543)	2.29509985
45	Hypoplasia of the radius (HP:0002984)	2.25900975
46	Abnormality of DNA repair (HP:0003254)	2.21455136
47	Abnormality of the labia minora (HP:0012880)	2.19768757
48	True hermaphroditism (HP:0010459)	2.17782659
49	Rib fusion (HP:0000902)	2.15555117
50	Hyperglycinemia (HP:0002154)	2.15268263
51	Abnormality of the renal medulla (HP:0100957)	2.13085824
52	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.11818236
53	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.11818236
54	Increased serum lactate (HP:0002151)	2.10077292
55	Ectopic kidney (HP:0000086)	2.09847423
56	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.06355271
57	Abnormality of alanine metabolism (HP:0010916)	2.06355271
58	Hyperalaninemia (HP:0003348)	2.06355271
59	Anencephaly (HP:0002323)	2.05977361
60	Postaxial foot polydactyly (HP:0001830)	2.04076181
61	Oligodactyly (hands) (HP:0001180)	2.03830655
62	Colon cancer (HP:0003003)	2.03419375
63	Abnormal drinking behavior (HP:0030082)	2.01605635
64	Polydipsia (HP:0001959)	2.01605635
65	Gait imbalance (HP:0002141)	2.01166112
66	Horseshoe kidney (HP:0000085)	2.00397181
67	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.00314458
68	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.00060452
69	Lactic acidosis (HP:0003128)	1.99173417
70	Adrenal hypoplasia (HP:0000835)	1.98213122
71	Hypoplasia of the ulna (HP:0003022)	1.97509639
72	Forearm undergrowth (HP:0009821)	1.96745366
73	Renal cortical cysts (HP:0000803)	1.96574361
74	Triphalangeal thumb (HP:0001199)	1.92394340
75	Bile duct proliferation (HP:0001408)	1.91912811
76	Abnormal biliary tract physiology (HP:0012439)	1.91912811
77	Myokymia (HP:0002411)	1.91088382
78	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.89663113
79	Depressed nasal ridge (HP:0000457)	1.89493096
80	Growth hormone deficiency (HP:0000824)	1.89050897
81	Supernumerary spleens (HP:0009799)	1.87946709
82	Increased intramyocellular lipid droplets (HP:0012240)	1.86792741
83	Congenital primary aphakia (HP:0007707)	1.86352499
84	Optic nerve hypoplasia (HP:0000609)	1.85789731
85	Cystic liver disease (HP:0006706)	1.85604325
86	Polyuria (HP:0000103)	1.84938610
87	Abnormality of magnesium homeostasis (HP:0004921)	1.84933959
88	Microretrognathia (HP:0000308)	1.83130996
89	Testicular atrophy (HP:0000029)	1.82680819
90	Occipital encephalocele (HP:0002085)	1.76579143
91	Nephrogenic diabetes insipidus (HP:0009806)	1.76128342
92	Leukodystrophy (HP:0002415)	1.75943267
93	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.75572729
94	Increased hepatocellular lipid droplets (HP:0006565)	1.75089215
95	Lethargy (HP:0001254)	1.74752275
96	Type 2 muscle fiber atrophy (HP:0003554)	1.73030382
97	Optic nerve coloboma (HP:0000588)	1.72893227
98	Renal Fanconi syndrome (HP:0001994)	1.72561108
99	Partial duplication of thumb phalanx (HP:0009944)	1.72415341
100	Tubular atrophy (HP:0000092)	1.71474052

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.34648052
2	WNK4	3.04376795
3	PINK1	2.63211017
4	ADRBK2	2.58397532
5	NME2	2.52017652
6	DYRK2	2.50417146
7	CAMKK2	2.42079683
8	BCKDK	2.36347270
9	CDK19	2.31981598
10	GRK1	2.20692745
11	TRIM28	2.15961194
12	PLK4	2.10871776
13	BMPR1B	2.04627284
14	LRRK2	2.03916720
15	PNCK	1.98928421
16	PIK3CA	1.93938822
17	NEK1	1.81712560
18	PDK2	1.72099657
19	MAP3K11	1.62462175
20	TIE1	1.61346560
21	PASK	1.60471606
22	WNK3	1.54069918
23	CDC7	1.42499380
24	BRAF	1.41798771
25	TXK	1.38761091
26	TYRO3	1.38375478
27	NUAK1	1.38268899
28	MAP4K2	1.37553605
29	INSRR	1.31978494
30	CAMK1	1.26345529
31	PRKCG	1.26116865
32	PLK2	1.18038208
33	EPHB2	1.17606550
34	FRK	1.17476505
35	CAMKK1	1.14061156
36	LIMK1	1.13988831
37	CAMK1G	1.11813817
38	STK39	1.08129689
39	MAP2K7	1.06348599
40	NTRK2	1.01938682
41	TLK1	0.99931316
42	FES	0.97566631
43	CAMK1D	0.97204989
44	VRK2	0.96986245
45	WNK1	0.91154922
46	ABL2	0.91114391
47	MAP3K9	0.90688469
48	MAPK13	0.89633413
49	TNIK	0.89270432
50	PRKCI	0.86313652
51	AKT3	0.84290951
52	ADRBK1	0.80704406
53	PHKG1	0.78358359
54	PHKG2	0.78358359
55	MAP3K4	0.77246839
56	AURKA	0.73813835
57	CASK	0.73660063
58	DMPK	0.72390624
59	VRK1	0.71110715
60	OBSCN	0.68915723
61	NME1	0.68611536
62	EPHA4	0.67394700
63	CSNK1G2	0.66888725
64	CSNK2A2	0.65068518
65	PRKCQ	0.63445025
66	PAK3	0.63313752
67	WEE1	0.62741751
68	PRKACA	0.62421171
69	STK11	0.61414935
70	MINK1	0.58972754
71	PRKCE	0.58135454
72	DAPK2	0.57848246
73	PIM2	0.57204737
74	CSNK1E	0.57135114
75	CSNK2A1	0.56316764
76	MAP2K6	0.56256017
77	DAPK3	0.55747835
78	ZAK	0.52766681
79	PRKCZ	0.51142834
80	PRKCH	0.49377982
81	CHEK2	0.48974266
82	AURKB	0.48539092
83	PLK1	0.48433915
84	BRSK1	0.48275355
85	CSNK1G3	0.46535194
86	OXSR1	0.45180292
87	MAPK12	0.44651114
88	PLK3	0.44590861
89	GRK7	0.42410088
90	TGFBR1	0.41482936
91	BRSK2	0.40892781
92	PRKCD	0.39887087
93	CAMK2A	0.38346807
94	CSNK1G1	0.37942300
95	PRKCA	0.37440728
96	MARK1	0.36197537
97	BCR	0.34818872
98	IKBKB	0.34550001
99	MARK3	0.34249747
100	TAOK1	0.33859213

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.01895856
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.19138620
3	Parkinsons disease_Homo sapiens_hsa05012	3.48018991
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.13639711
5	RNA polymerase_Homo sapiens_hsa03020	2.71420018
6	Huntingtons disease_Homo sapiens_hsa05016	2.55607456
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.55483926
8	Alzheimers disease_Homo sapiens_hsa05010	2.36867076
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.31637181
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.02920670
11	Protein export_Homo sapiens_hsa03060	2.00940584
12	Proteasome_Homo sapiens_hsa03050	1.96965170
13	Pyrimidine metabolism_Homo sapiens_hsa00240	1.72724749
14	RNA degradation_Homo sapiens_hsa03018	1.66299312
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.63902924
16	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.57170333
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.57156588
18	Homologous recombination_Homo sapiens_hsa03440	1.56874833
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.50252151
20	Fat digestion and absorption_Homo sapiens_hsa04975	1.47638916
21	One carbon pool by folate_Homo sapiens_hsa00670	1.41787501
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.39904817
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.37046571
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.33981792
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.30208831
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.28438057
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.25256785
28	Purine metabolism_Homo sapiens_hsa00230	1.18809868
29	Basal transcription factors_Homo sapiens_hsa03022	1.16934277
30	Sulfur relay system_Homo sapiens_hsa04122	1.09131115
31	Phototransduction_Homo sapiens_hsa04744	1.01612202
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.95347657
33	RNA transport_Homo sapiens_hsa03013	0.93207590
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.92991732
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.91965021
36	Ether lipid metabolism_Homo sapiens_hsa00565	0.91494410
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.89554127
38	Mismatch repair_Homo sapiens_hsa03430	0.88369941
39	DNA replication_Homo sapiens_hsa03030	0.88339465
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.86980677
41	Nicotine addiction_Homo sapiens_hsa05033	0.86545796
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.86051894
43	Peroxisome_Homo sapiens_hsa04146	0.85712049
44	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.85689284
45	Spliceosome_Homo sapiens_hsa03040	0.85651212
46	Metabolic pathways_Homo sapiens_hsa01100	0.85237569
47	Retinol metabolism_Homo sapiens_hsa00830	0.85059292
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.84519351
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.82559849
50	Caffeine metabolism_Homo sapiens_hsa00232	0.80754659
51	Olfactory transduction_Homo sapiens_hsa04740	0.78683484
52	Propanoate metabolism_Homo sapiens_hsa00640	0.77473008
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76219230
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76046986
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.74860318
56	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.74823679
57	Basal cell carcinoma_Homo sapiens_hsa05217	0.74342702
58	Butanoate metabolism_Homo sapiens_hsa00650	0.72777350
59	Base excision repair_Homo sapiens_hsa03410	0.70075961
60	Selenocompound metabolism_Homo sapiens_hsa00450	0.69030979
61	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65920594
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64659649
63	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.62683578
64	Fatty acid degradation_Homo sapiens_hsa00071	0.60156579
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59940909
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.57269053
67	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.55812505
68	Morphine addiction_Homo sapiens_hsa05032	0.55095479
69	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.54332895
70	Pyruvate metabolism_Homo sapiens_hsa00620	0.53715973
71	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.51833003
72	Insulin secretion_Homo sapiens_hsa04911	0.48836662
73	Asthma_Homo sapiens_hsa05310	0.48775021
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48299400
75	Sulfur metabolism_Homo sapiens_hsa00920	0.47355452
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45470215
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.44194283
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.43325430
79	Folate biosynthesis_Homo sapiens_hsa00790	0.41326533
80	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.40161510
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39675421
82	Glutathione metabolism_Homo sapiens_hsa00480	0.38918222
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.35569988
84	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.30928294
85	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.30176048
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.27864174
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.27073081
88	Hippo signaling pathway_Homo sapiens_hsa04390	0.26985760
89	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.25501053
90	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.25049471
91	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.23814819
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.23318096
93	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.22507299
94	Serotonergic synapse_Homo sapiens_hsa04726	0.22204561
95	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.21256620
96	Taste transduction_Homo sapiens_hsa04742	0.21248962
97	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.21001538
98	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.20321188
99	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.19018316
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.19009336

RPL17P22

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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