ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.14934222
2	translational termination (GO:0006415)	7.77339793
3	ribosomal small subunit biogenesis (GO:0042274)	7.77245372
4	ribosomal small subunit assembly (GO:0000028)	7.14875128
5	maturation of SSU-rRNA (GO:0030490)	6.64206872
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.37616180
7	translational elongation (GO:0006414)	6.36232834
8	cotranslational protein targeting to membrane (GO:0006613)	6.33290125
9	protein targeting to ER (GO:0045047)	6.27041413
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.02044261
11	cellular protein complex disassembly (GO:0043624)	5.93361826
12	viral life cycle (GO:0019058)	5.89518574
13	protein localization to endoplasmic reticulum (GO:0070972)	5.88884297
14	behavioral response to nicotine (GO:0035095)	5.83759054
15	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.71947029
16	protein complex disassembly (GO:0043241)	5.14537190
17	macromolecular complex disassembly (GO:0032984)	4.85381857
18	translational initiation (GO:0006413)	4.73889397
19	chaperone-mediated protein transport (GO:0072321)	4.68148700
20	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.44193934
21	ATP synthesis coupled proton transport (GO:0015986)	4.44193934
22	substrate-independent telencephalic tangential migration (GO:0021826)	4.43052995
23	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.43052995
24	cell proliferation in forebrain (GO:0021846)	4.40121175
25	protein targeting to membrane (GO:0006612)	4.29147686
26	protein neddylation (GO:0045116)	4.23254362
27	ribosomal large subunit biogenesis (GO:0042273)	4.09159922
28	pyrimidine nucleobase catabolic process (GO:0006208)	3.97045799
29	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.93001426
30	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.89861384
31	nonmotile primary cilium assembly (GO:0035058)	3.80660509
32	mRNA catabolic process (GO:0006402)	3.69431870
33	tongue development (GO:0043586)	3.66600344
34	translation (GO:0006412)	3.58004816
35	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.52378709
36	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.52123708
37	GTP biosynthetic process (GO:0006183)	3.43569558
38	ribonucleoprotein complex biogenesis (GO:0022613)	3.38252880
39	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.36883082
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.36883082
41	NADH dehydrogenase complex assembly (GO:0010257)	3.36883082
42	pattern specification involved in kidney development (GO:0061004)	3.32487480
43	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.29185800
44	RNA catabolic process (GO:0006401)	3.28265573
45	spinal cord association neuron differentiation (GO:0021527)	3.27916725
46	protein complex biogenesis (GO:0070271)	3.25040450
47	cellular component biogenesis (GO:0044085)	3.23907626
48	nucleobase catabolic process (GO:0046113)	3.15222100
49	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.11019134
50	head development (GO:0060322)	3.10871383
51	somite development (GO:0061053)	3.09471857
52	synaptic transmission, cholinergic (GO:0007271)	3.07377668
53	neuron fate determination (GO:0048664)	3.05828463
54	respiratory electron transport chain (GO:0022904)	3.05504243
55	cardiovascular system development (GO:0072358)	3.05241309
56	electron transport chain (GO:0022900)	3.04697693
57	regulation of cilium movement (GO:0003352)	3.04340046
58	central nervous system myelination (GO:0022010)	3.03930227
59	axon ensheathment in central nervous system (GO:0032291)	3.03930227
60	regulation of microtubule-based movement (GO:0060632)	3.03076643
61	establishment of mitochondrion localization (GO:0051654)	3.02724576
62	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.02293250
63	UTP biosynthetic process (GO:0006228)	2.95179598
64	axonal fasciculation (GO:0007413)	2.94860117
65	auditory receptor cell differentiation (GO:0042491)	2.93216712
66	positive regulation of respiratory burst (GO:0060267)	2.92867392
67	epithelial cilium movement (GO:0003351)	2.92804205
68	establishment of protein localization to membrane (GO:0090150)	2.90640383
69	hypothalamus development (GO:0021854)	2.88533591
70	mitochondrial respiratory chain complex assembly (GO:0033108)	2.88106576
71	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.87456677
72	telencephalon development (GO:0021537)	2.84329118
73	protein targeting (GO:0006605)	2.83159855
74	negative regulation of appetite (GO:0032099)	2.82352630
75	negative regulation of response to food (GO:0032096)	2.82352630
76	pyrimidine nucleotide catabolic process (GO:0006244)	2.81309297
77	UTP metabolic process (GO:0046051)	2.81220904
78	positive regulation of T cell apoptotic process (GO:0070234)	2.79557150
79	cerebral cortex radially oriented cell migration (GO:0021799)	2.77446006
80	mitochondrion transport along microtubule (GO:0047497)	2.74048214
81	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.74048214
82	body morphogenesis (GO:0010171)	2.72869660
83	CTP metabolic process (GO:0046036)	2.72703995
84	CTP biosynthetic process (GO:0006241)	2.72703995
85	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.72699115
86	postsynaptic membrane organization (GO:0001941)	2.68336530
87	parturition (GO:0007567)	2.68261441
88	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.67493071
89	transmission of nerve impulse (GO:0019226)	2.64691667
90	establishment of protein localization to organelle (GO:0072594)	2.64043095
91	protein polyglutamylation (GO:0018095)	2.62577649
92	neuron recognition (GO:0008038)	2.62271699
93	segment specification (GO:0007379)	2.60904486
94	genetic imprinting (GO:0071514)	2.52716489
95	intraciliary transport (GO:0042073)	2.52545839
96	ubiquinone biosynthetic process (GO:0006744)	2.51995111
97	ATP biosynthetic process (GO:0006754)	2.50318976
98	ncRNA 3-end processing (GO:0043628)	2.48923045
99	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.47546233
100	axonemal dynein complex assembly (GO:0070286)	2.46398799

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.01919867
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.42862095
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.37097765
4	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.45919786
5	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.40632341
6	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.33051530
7	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.20562360
8	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.17726706
9	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.10298564
10	IRF1_19129219_ChIP-ChIP_H3396_Human	2.05444880
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.04548512
12	REST_21632747_ChIP-Seq_MESCs_Mouse	2.02596155
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.00730872
14	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.97992356
15	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.96148988
16	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.93463393
17	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.86475895
18	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.81842961
19	VDR_22108803_ChIP-Seq_LS180_Human	1.76832179
20	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.74887273
21	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.74887273
22	ZNF274_21170338_ChIP-Seq_K562_Hela	1.72756615
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.69797652
24	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.65702031
25	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.62332691
26	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.57919173
27	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.56128155
28	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.55633040
29	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.54418650
30	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.53454027
31	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.53243320
32	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.51235196
33	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.47136734
34	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.43743895
35	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.43579077
36	RNF2_27304074_Chip-Seq_NSC_Mouse	1.43052147
37	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.41229044
38	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.40898774
39	CTCF_27219007_Chip-Seq_Bcells_Human	1.40077876
40	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.38817481
41	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.36368210
42	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.34897809
43	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.32800305
44	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.29535268
45	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.27926558
46	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.24014807
47	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.23338585
48	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.20824027
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.19440313
50	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.17821722
51	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.17624605
52	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.17593785
53	ERA_21632823_ChIP-Seq_H3396_Human	1.17200735
54	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.16628434
55	TTF2_22483619_ChIP-Seq_HELA_Human	1.16383572
56	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.16275165
57	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.16020707
58	XRN2_22483619_ChIP-Seq_HELA_Human	1.15610691
59	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.15376998
60	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.13479494
61	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.13055982
62	TAF2_19829295_ChIP-Seq_ESCs_Human	1.11790444
63	NANOG_20526341_ChIP-Seq_ESCs_Human	1.11307332
64	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.10472589
65	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.10168281
66	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.09982698
67	MYC_18940864_ChIP-ChIP_HL60_Human	1.09870567
68	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.06008560
69	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.05578412
70	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.05269075
71	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.04300075
72	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.03844769
73	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.03447232
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02786331
75	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02194640
76	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.00932865
77	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.00435325
78	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.98844784
79	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.96996887
80	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.96688919
81	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.96618226
82	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.96580237
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96438489
84	P68_20966046_ChIP-Seq_HELA_Human	0.95409038
85	TP53_22573176_ChIP-Seq_HFKS_Human	0.95268607
86	NCOR_22424771_ChIP-Seq_293T_Human	0.95227653
87	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.93787106
88	GABP_19822575_ChIP-Seq_HepG2_Human	0.93584318
89	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.92815576
90	CTCF_20526341_ChIP-Seq_ESCs_Human	0.92512891
91	SA1_27219007_Chip-Seq_Bcells_Human	0.91171971
92	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.90578506
93	OCT4_19829295_ChIP-Seq_ESCs_Human	0.88877418
94	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.88495484
95	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.87211608
96	BCL6_27268052_Chip-Seq_Bcells_Human	0.87131398
97	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.85326602
98	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.84145185
99	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.83549535
100	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.82487559

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.72075039
2	MP0006292_abnormal_olfactory_placode	4.81990652
3	MP0003787_abnormal_imprinting	3.83830954
4	MP0003122_maternal_imprinting	3.06384241
5	MP0003123_paternal_imprinting	2.85132414
6	MP0002653_abnormal_ependyma_morphology	2.73728943
7	MP0008789_abnormal_olfactory_epithelium	2.72575340
8	MP0005394_taste/olfaction_phenotype	2.53394135
9	MP0005499_abnormal_olfactory_system	2.53394135
10	MP0003121_genomic_imprinting	2.50081327
11	MP0002163_abnormal_gland_morphology	2.40226358
12	MP0004142_abnormal_muscle_tone	2.15691726
13	MP0000778_abnormal_nervous_system	2.14908112
14	MP0008877_abnormal_DNA_methylation	2.04739517
15	MP0001293_anophthalmia	2.04163432
16	MP0006276_abnormal_autonomic_nervous	2.03730387
17	MP0000049_abnormal_middle_ear	1.92963036
18	MP0003878_abnormal_ear_physiology	1.87229856
19	MP0005377_hearing/vestibular/ear_phenot	1.87229856
20	MP0001485_abnormal_pinna_reflex	1.84514803
21	MP0003136_yellow_coat_color	1.82553809
22	MP0003880_abnormal_central_pattern	1.65221894
23	MP0003879_abnormal_hair_cell	1.50123545
24	MP0002272_abnormal_nervous_system	1.49896533
25	MP0000566_synostosis	1.49120836
26	MP0005423_abnormal_somatic_nervous	1.48569459
27	MP0004885_abnormal_endolymph	1.48257605
28	MP0001968_abnormal_touch/_nociception	1.44516921
29	MP0010030_abnormal_orbit_morphology	1.43576466
30	MP0002638_abnormal_pupillary_reflex	1.43198126
31	MP0000955_abnormal_spinal_cord	1.42556562
32	MP0000631_abnormal_neuroendocrine_gland	1.42259311
33	MP0004742_abnormal_vestibular_system	1.38926371
34	MP0003646_muscle_fatigue	1.38321954
35	MP0001984_abnormal_olfaction	1.38231881
36	MP0004133_heterotaxia	1.37161984
37	MP0002938_white_spotting	1.32416026
38	MP0002736_abnormal_nociception_after	1.32130927
39	MP0002557_abnormal_social/conspecific_i	1.31493691
40	MP0004859_abnormal_synaptic_plasticity	1.31061528
41	MP0001529_abnormal_vocalization	1.30781300
42	MP0002184_abnormal_innervation	1.28023563
43	MP0005551_abnormal_eye_electrophysiolog	1.27621273
44	MP0001440_abnormal_grooming_behavior	1.26331095
45	MP0009745_abnormal_behavioral_response	1.25847602
46	MP0002160_abnormal_reproductive_system	1.24996088
47	MP0005195_abnormal_posterior_eye	1.24791432
48	MP0002063_abnormal_learning/memory/cond	1.24560051
49	MP0003635_abnormal_synaptic_transmissio	1.23832404
50	MP0005379_endocrine/exocrine_gland_phen	1.23540776
51	MP0002733_abnormal_thermal_nociception	1.19688644
52	MP0002752_abnormal_somatic_nervous	1.18712468
53	MP0003011_delayed_dark_adaptation	1.17660654
54	MP0002102_abnormal_ear_morphology	1.16916922
55	MP0000026_abnormal_inner_ear	1.16124368
56	MP0001970_abnormal_pain_threshold	1.15676295
57	MP0004145_abnormal_muscle_electrophysio	1.15576929
58	MP0003938_abnormal_ear_development	1.12224499
59	MP0003942_abnormal_urinary_system	1.10969132
60	MP0009046_muscle_twitch	1.10795170
61	MP0002876_abnormal_thyroid_physiology	1.10618973
62	MP0001986_abnormal_taste_sensitivity	1.10548475
63	MP0002572_abnormal_emotion/affect_behav	1.10056795
64	MP0008872_abnormal_physiological_respon	1.03782520
65	MP0002067_abnormal_sensory_capabilities	1.03688824
66	MP0002734_abnormal_mechanical_nocicepti	1.03354245
67	MP0001905_abnormal_dopamine_level	1.01703984
68	MP0002234_abnormal_pharynx_morphology	1.01339761
69	MP0002882_abnormal_neuron_morphology	1.01276048
70	MP0002837_dystrophic_cardiac_calcinosis	1.00768263
71	MP0002233_abnormal_nose_morphology	0.99553307
72	MP0006072_abnormal_retinal_apoptosis	0.97693934
73	MP0003890_abnormal_embryonic-extraembry	0.96523666
74	MP0005646_abnormal_pituitary_gland	0.96102132
75	MP0005389_reproductive_system_phenotype	0.95852689
76	MP0001286_abnormal_eye_development	0.95400103
77	MP0002152_abnormal_brain_morphology	0.94660734
78	MP0001963_abnormal_hearing_physiology	0.92940186
79	MP0003755_abnormal_palate_morphology	0.90317670
80	MP0001502_abnormal_circadian_rhythm	0.90219528
81	MP0002095_abnormal_skin_pigmentation	0.89078417
82	MP0002064_seizures	0.88587100
83	MP0003861_abnormal_nervous_system	0.87177109
84	MP0009053_abnormal_anal_canal	0.87023773
85	MP0008775_abnormal_heart_ventricle	0.84399906
86	MP0004130_abnormal_muscle_cell	0.81319623
87	MP0001486_abnormal_startle_reflex	0.81306282
88	MP0001919_abnormal_reproductive_system	0.80929860
89	MP0002249_abnormal_larynx_morphology	0.80467860
90	MP0003937_abnormal_limbs/digits/tail_de	0.78881961
91	MP0002735_abnormal_chemical_nociception	0.77680789
92	MP0001348_abnormal_lacrimal_gland	0.77323758
93	MP0005645_abnormal_hypothalamus_physiol	0.76206819
94	MP0004924_abnormal_behavior	0.76040545
95	MP0005386_behavior/neurological_phenoty	0.76040545
96	MP0008875_abnormal_xenobiotic_pharmacok	0.75583648
97	MP0005391_vision/eye_phenotype	0.72487167
98	MP0004811_abnormal_neuron_physiology	0.72224575
99	MP0005174_abnormal_tail_pigmentation	0.72067785
100	MP0002697_abnormal_eye_size	0.71909180

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.10408384
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.93369976
3	Molar tooth sign on MRI (HP:0002419)	4.02947845
4	Abnormality of midbrain morphology (HP:0002418)	4.02947845
5	Macrocytic anemia (HP:0001972)	3.79342713
6	Pancreatic fibrosis (HP:0100732)	3.67955074
7	Septo-optic dysplasia (HP:0100842)	3.54778390
8	Acute necrotizing encephalopathy (HP:0006965)	3.47697527
9	Abnormal number of erythroid precursors (HP:0012131)	3.45638378
10	Nephronophthisis (HP:0000090)	3.21558685
11	Medial flaring of the eyebrow (HP:0010747)	3.19863544
12	Colon cancer (HP:0003003)	3.19039146
13	Pallor (HP:0000980)	3.16576744
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.14780045
15	Myokymia (HP:0002411)	3.01539330
16	Acute encephalopathy (HP:0006846)	2.98941063
17	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.93765846
18	Rib fusion (HP:0000902)	2.84993541
19	Gait imbalance (HP:0002141)	2.81534673
20	Pancreatic cysts (HP:0001737)	2.80649035
21	Stenosis of the external auditory canal (HP:0000402)	2.80504127
22	Absent thumb (HP:0009777)	2.75219877
23	Abnormality of the renal medulla (HP:0100957)	2.67618345
24	Progressive macrocephaly (HP:0004481)	2.66313010
25	Hyperthyroidism (HP:0000836)	2.64493390
26	Mitochondrial inheritance (HP:0001427)	2.64355223
27	Asplenia (HP:0001746)	2.62996333
28	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.62974572
29	Sclerocornea (HP:0000647)	2.61114129
30	True hermaphroditism (HP:0010459)	2.59604758
31	Congenital primary aphakia (HP:0007707)	2.54065872
32	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.49867112
33	Chronic hepatic failure (HP:0100626)	2.47912230
34	Agitation (HP:0000713)	2.46785217
35	Nephrogenic diabetes insipidus (HP:0009806)	2.44298223
36	Adrenal hypoplasia (HP:0000835)	2.41782200
37	Partial duplication of thumb phalanx (HP:0009944)	2.39020067
38	Depressed nasal ridge (HP:0000457)	2.38991667
39	Anophthalmia (HP:0000528)	2.38186729
40	Pendular nystagmus (HP:0012043)	2.36724669
41	Abnormality of the labia minora (HP:0012880)	2.35460021
42	Type II lissencephaly (HP:0007260)	2.35388062
43	Congenital stationary night blindness (HP:0007642)	2.34826710
44	Anencephaly (HP:0002323)	2.34803267
45	Cystic liver disease (HP:0006706)	2.29870121
46	Hypoplasia of the radius (HP:0002984)	2.24506461
47	Polyphagia (HP:0002591)	2.22728009
48	Absent/shortened dynein arms (HP:0200106)	2.18979916
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.18979916
50	Increased CSF lactate (HP:0002490)	2.18694514
51	Tubular atrophy (HP:0000092)	2.18064276
52	Postaxial foot polydactyly (HP:0001830)	2.15602794
53	Optic nerve hypoplasia (HP:0000609)	2.15032600
54	Maternal diabetes (HP:0009800)	2.15012839
55	Poor coordination (HP:0002370)	2.14441577
56	Oligodactyly (hands) (HP:0001180)	2.10234266
57	Growth hormone deficiency (HP:0000824)	2.09171809
58	Hepatocellular necrosis (HP:0001404)	2.08627450
59	Optic disc pallor (HP:0000543)	2.08572333
60	Abnormal rod and cone electroretinograms (HP:0008323)	2.06398999
61	Oligodactyly (HP:0012165)	2.05465346
62	Cerebral edema (HP:0002181)	2.04760167
63	Absent septum pellucidum (HP:0001331)	2.03676127
64	Abnormality of the aortic arch (HP:0012303)	2.03170782
65	Hyperglycinemia (HP:0002154)	2.02588218
66	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.02248640
67	Polydipsia (HP:0001959)	2.01273291
68	Abnormal drinking behavior (HP:0030082)	2.01273291
69	11 pairs of ribs (HP:0000878)	2.00752415
70	Diastasis recti (HP:0001540)	2.00255053
71	Vaginal atresia (HP:0000148)	1.98569329
72	Optic nerve coloboma (HP:0000588)	1.95518469
73	Abnormality of the renal cortex (HP:0011035)	1.95439379
74	Supernumerary spleens (HP:0009799)	1.92780655
75	Pachygyria (HP:0001302)	1.91748620
76	Partial duplication of the phalanx of hand (HP:0009999)	1.91345175
77	Abnormal hair whorl (HP:0010721)	1.90998039
78	Abnormal respiratory motile cilium morphology (HP:0005938)	1.89974303
79	Abnormal respiratory epithelium morphology (HP:0012253)	1.89974303
80	Abnormality of DNA repair (HP:0003254)	1.89906076
81	Genital tract atresia (HP:0001827)	1.89335920
82	Bile duct proliferation (HP:0001408)	1.88705256
83	Abnormal biliary tract physiology (HP:0012439)	1.88705256
84	Abnormal ciliary motility (HP:0012262)	1.85186840
85	Congenital hepatic fibrosis (HP:0002612)	1.85161588
86	Hip dysplasia (HP:0001385)	1.84009858
87	Hepatic necrosis (HP:0002605)	1.82279336
88	Polyuria (HP:0000103)	1.81461297
89	Lissencephaly (HP:0001339)	1.81458794
90	Hypoplasia of the ulna (HP:0003022)	1.81295791
91	Forearm undergrowth (HP:0009821)	1.81226716
92	Holoprosencephaly (HP:0001360)	1.80819351
93	Ectopic kidney (HP:0000086)	1.78294784
94	Aganglionic megacolon (HP:0002251)	1.77830087
95	Narrow forehead (HP:0000341)	1.77524194
96	Postaxial hand polydactyly (HP:0001162)	1.77446703
97	Abnormality of reticulocytes (HP:0004312)	1.73039298
98	Abnormality of the diencephalon (HP:0010662)	1.71690082
99	Abnormal hemoglobin (HP:0011902)	1.69920093
100	Shawl scrotum (HP:0000049)	1.69195378

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.35606472
2	STK16	2.90759354
3	DYRK2	2.86822204
4	CDK19	2.66354149
5	PINK1	2.64484559
6	PIK3CA	2.56317022
7	EPHB2	2.35908084
8	ADRBK2	2.27743570
9	BCKDK	2.08295931
10	MAP3K11	2.06500575
11	CASK	1.98460238
12	NTRK2	1.92015673
13	WNK3	1.84687415
14	LRRK2	1.82326629
15	MAP3K9	1.76638635
16	GRK1	1.65220532
17	MAP2K7	1.64886524
18	TYRO3	1.61869601
19	TNIK	1.56096535
20	BMPR1B	1.51288919
21	STK39	1.51201215
22	SIK2	1.48322854
23	NUAK1	1.47806466
24	MARK1	1.45634840
25	PRKCG	1.42984840
26	EPHA4	1.42049290
27	CDC7	1.38752710
28	CAMKK2	1.34326736
29	DYRK1B	1.32062012
30	CAMKK1	1.31855493
31	CAMK1	1.29979179
32	ARAF	1.27579709
33	MAP3K4	1.26792401
34	TIE1	1.25109213
35	BRAF	1.21418310
36	NME2	1.16067701
37	NME1	1.12931001
38	DMPK	1.12496422
39	PRKD3	1.10596150
40	PAK3	1.10532946
41	DYRK3	1.05676164
42	ZAK	1.05227009
43	SGK494	1.03325944
44	SGK223	1.03325944
45	MAPK13	1.02562790
46	STK11	1.01859067
47	LIMK1	0.99195167
48	CAMK1D	0.97907453
49	MINK1	0.96644942
50	FRK	0.91513240
51	PIM2	0.89761502
52	PRKCH	0.89347291
53	WNK1	0.88900853
54	NTRK3	0.84352263
55	PASK	0.84160786
56	MARK2	0.83658452
57	PRKCQ	0.82934935
58	ADRBK1	0.81786346
59	CAMK1G	0.80441107
60	RPS6KA6	0.76804922
61	OXSR1	0.75824494
62	PRKCZ	0.74374527
63	ABL2	0.73109830
64	PDK2	0.72684125
65	TLK1	0.70685863
66	PRKCI	0.69711848
67	CAMK4	0.69610289
68	DYRK1A	0.68460988
69	AURKA	0.67736508
70	PRKACA	0.66805151
71	MAP2K4	0.64411057
72	NEK2	0.62419558
73	CSNK1G2	0.62305247
74	TAF1	0.62140254
75	TXK	0.62043455
76	CSNK1E	0.61353519
77	MAPK15	0.61270470
78	CSNK2A2	0.60265104
79	RPS6KC1	0.60119730
80	RPS6KL1	0.60119730
81	SGK1	0.60031974
82	DAPK3	0.58343389
83	VRK2	0.57524077
84	RPS6KA2	0.51274249
85	CDK5	0.50968947
86	PHKG1	0.50924402
87	PHKG2	0.50924402
88	MUSK	0.49302257
89	INSRR	0.48312614
90	NTRK1	0.48311933
91	PRKCD	0.46089115
92	PLK1	0.45145889
93	AURKB	0.43092182
94	CDK14	0.42245180
95	CHEK2	0.42001330
96	MAP4K2	0.41851199
97	CDK11A	0.41348492
98	SGK2	0.40511591
99	PRKCA	0.39495527
100	PLK2	0.38613685

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.18720526
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.01471435
3	Parkinsons disease_Homo sapiens_hsa05012	3.42440657
4	Cardiac muscle contraction_Homo sapiens_hsa04260	3.02369279
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.98727200
6	Huntingtons disease_Homo sapiens_hsa05016	2.57468166
7	Sulfur relay system_Homo sapiens_hsa04122	2.57429642
8	Alzheimers disease_Homo sapiens_hsa05010	2.41998566
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.19890395
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.08915530
11	RNA polymerase_Homo sapiens_hsa03020	1.98756652
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.93694639
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.89150451
14	Nicotine addiction_Homo sapiens_hsa05033	1.79171197
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.66689330
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.63517966
17	Protein export_Homo sapiens_hsa03060	1.42828481
18	Phototransduction_Homo sapiens_hsa04744	1.34557425
19	Basal cell carcinoma_Homo sapiens_hsa05217	1.32674011
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.32146162
21	Steroid biosynthesis_Homo sapiens_hsa00100	1.29296123
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.23011412
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.20793568
24	Homologous recombination_Homo sapiens_hsa03440	1.19735444
25	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.19458869
26	RNA degradation_Homo sapiens_hsa03018	1.16225944
27	Butanoate metabolism_Homo sapiens_hsa00650	1.14279908
28	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.12264280
29	Caffeine metabolism_Homo sapiens_hsa00232	1.11051572
30	Notch signaling pathway_Homo sapiens_hsa04330	1.09574033
31	Peroxisome_Homo sapiens_hsa04146	1.07162552
32	Fat digestion and absorption_Homo sapiens_hsa04975	1.05999775
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.05267568
34	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.04064901
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.03940365
36	Morphine addiction_Homo sapiens_hsa05032	1.03494550
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.99790426
38	Basal transcription factors_Homo sapiens_hsa03022	0.96581563
39	Axon guidance_Homo sapiens_hsa04360	0.92645169
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.89886687
41	Insulin secretion_Homo sapiens_hsa04911	0.88901002
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86343743
43	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.86217093
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.82520579
45	Ether lipid metabolism_Homo sapiens_hsa00565	0.81255201
46	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77104370
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.73367359
48	Metabolic pathways_Homo sapiens_hsa01100	0.72347324
49	Glutamatergic synapse_Homo sapiens_hsa04724	0.71773509
50	Fatty acid degradation_Homo sapiens_hsa00071	0.71573254
51	Propanoate metabolism_Homo sapiens_hsa00640	0.70627682
52	GABAergic synapse_Homo sapiens_hsa04727	0.69803961
53	Retinol metabolism_Homo sapiens_hsa00830	0.69497314
54	Olfactory transduction_Homo sapiens_hsa04740	0.69384705
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67929876
56	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.67293473
57	Nucleotide excision repair_Homo sapiens_hsa03420	0.66084976
58	One carbon pool by folate_Homo sapiens_hsa00670	0.63391049
59	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.60610589
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.58414690
61	Base excision repair_Homo sapiens_hsa03410	0.58330611
62	Hippo signaling pathway_Homo sapiens_hsa04390	0.58326920
63	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.58238190
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.54921959
65	Purine metabolism_Homo sapiens_hsa00230	0.53742122
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.53682539
67	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.53119702
68	Folate biosynthesis_Homo sapiens_hsa00790	0.52468830
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51947118
70	Cholinergic synapse_Homo sapiens_hsa04725	0.51726129
71	Arginine and proline metabolism_Homo sapiens_hsa00330	0.51179487
72	Serotonergic synapse_Homo sapiens_hsa04726	0.50440665
73	Taste transduction_Homo sapiens_hsa04742	0.49722320
74	Pyruvate metabolism_Homo sapiens_hsa00620	0.48913391
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48035884
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.47045643
77	Nitrogen metabolism_Homo sapiens_hsa00910	0.46189991
78	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.46159707
79	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.45930010
80	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45491212
81	Cocaine addiction_Homo sapiens_hsa05030	0.40633697
82	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.40275569
83	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.40029068
84	Dopaminergic synapse_Homo sapiens_hsa04728	0.38868037
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38680926
86	Circadian entrainment_Homo sapiens_hsa04713	0.37106415
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.36453438
88	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.32218380
89	DNA replication_Homo sapiens_hsa03030	0.31416302
90	Wnt signaling pathway_Homo sapiens_hsa04310	0.31159351
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.31100219
92	Mismatch repair_Homo sapiens_hsa03430	0.30841299
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.27324212
94	Proteasome_Homo sapiens_hsa03050	0.26302031
95	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.23286697
96	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.22920438
97	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.22759349
98	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.22743904
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.21413148
100	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.21241032

RPL17P25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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