ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.00219438
2	translational termination (GO:0006415)	7.63678463
3	ribosomal small subunit biogenesis (GO:0042274)	7.14350553
4	maturation of SSU-rRNA (GO:0030490)	6.85992722
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.56318451
6	cotranslational protein targeting to membrane (GO:0006613)	6.49939500
7	protein targeting to ER (GO:0045047)	6.46423479
8	translational elongation (GO:0006414)	6.33143932
9	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.20010483
10	ribosomal small subunit assembly (GO:0000028)	6.12544134
11	protein localization to endoplasmic reticulum (GO:0070972)	6.04701906
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.81697612
13	ATP synthesis coupled proton transport (GO:0015986)	5.81697612
14	cellular protein complex disassembly (GO:0043624)	5.81346172
15	viral life cycle (GO:0019058)	5.72483818
16	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.67070245
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.54481928
18	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.51722859
19	chaperone-mediated protein transport (GO:0072321)	5.17243125
20	ribosomal large subunit biogenesis (GO:0042273)	5.14419317
21	translational initiation (GO:0006413)	5.00133842
22	behavioral response to nicotine (GO:0035095)	4.92405242
23	protein complex disassembly (GO:0043241)	4.90580752
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.86238334
25	NADH dehydrogenase complex assembly (GO:0010257)	4.86238334
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.86238334
27	protein complex biogenesis (GO:0070271)	4.77613740
28	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.76890233
29	protein neddylation (GO:0045116)	4.73267251
30	macromolecular complex disassembly (GO:0032984)	4.65241057
31	protein targeting to membrane (GO:0006612)	4.41330923
32	respiratory electron transport chain (GO:0022904)	4.32036628
33	electron transport chain (GO:0022900)	4.27027451
34	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.24057958
35	substrate-independent telencephalic tangential migration (GO:0021826)	4.24057958
36	mitochondrial respiratory chain complex assembly (GO:0033108)	4.21900485
37	translation (GO:0006412)	4.09478265
38	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.97476726
39	cellular component biogenesis (GO:0044085)	3.79774044
40	mRNA catabolic process (GO:0006402)	3.74909040
41	cardiovascular system development (GO:0072358)	3.69454099
42	ribonucleoprotein complex biogenesis (GO:0022613)	3.67677786
43	platelet dense granule organization (GO:0060155)	3.67362257
44	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.39429008
45	neuron fate determination (GO:0048664)	3.39188558
46	ATP biosynthetic process (GO:0006754)	3.37803368
47	tongue development (GO:0043586)	3.36975363
48	RNA catabolic process (GO:0006401)	3.34070278
49	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.30616110
50	cell proliferation in forebrain (GO:0021846)	3.28240594
51	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.27242709
52	pattern specification involved in kidney development (GO:0061004)	3.24578688
53	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.23037504
54	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.23037504
55	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.20012149
56	hydrogen ion transmembrane transport (GO:1902600)	3.19532081
57	GTP biosynthetic process (GO:0006183)	3.07856459
58	pyrimidine nucleobase catabolic process (GO:0006208)	3.06842851
59	rRNA processing (GO:0006364)	3.04453747
60	synaptic transmission, cholinergic (GO:0007271)	3.01496378
61	rRNA metabolic process (GO:0016072)	3.00280538
62	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.97314471
63	water-soluble vitamin biosynthetic process (GO:0042364)	2.96449057
64	intraciliary transport (GO:0042073)	2.94127893
65	establishment of protein localization to membrane (GO:0090150)	2.94043825
66	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.92669823
67	protein polyglutamylation (GO:0018095)	2.92519548
68	protein targeting (GO:0006605)	2.87963748
69	DNA deamination (GO:0045006)	2.86040768
70	epithelial cilium movement (GO:0003351)	2.85254759
71	intracellular protein transmembrane import (GO:0044743)	2.83513900
72	positive regulation of T cell apoptotic process (GO:0070234)	2.82294837
73	proton transport (GO:0015992)	2.82236876
74	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.80693108
75	somite development (GO:0061053)	2.79041888
76	hydrogen transport (GO:0006818)	2.75266420
77	axon ensheathment in central nervous system (GO:0032291)	2.73549182
78	central nervous system myelination (GO:0022010)	2.73549182
79	UTP biosynthetic process (GO:0006228)	2.70786565
80	anterograde synaptic vesicle transport (GO:0048490)	2.70738533
81	thalamus development (GO:0021794)	2.70296101
82	anterograde axon cargo transport (GO:0008089)	2.67306570
83	establishment of protein localization to organelle (GO:0072594)	2.65178114
84	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.63485182
85	resolution of meiotic recombination intermediates (GO:0000712)	2.59468237
86	respiratory chain complex IV assembly (GO:0008535)	2.58688469
87	transmission of nerve impulse (GO:0019226)	2.58193299
88	aldehyde catabolic process (GO:0046185)	2.55536163
89	segment specification (GO:0007379)	2.53132736
90	nucleobase catabolic process (GO:0046113)	2.53122063
91	regulation of cilium movement (GO:0003352)	2.52696771
92	pseudouridine synthesis (GO:0001522)	2.51128021
93	nucleoside triphosphate biosynthetic process (GO:0009142)	2.48457674
94	preassembly of GPI anchor in ER membrane (GO:0016254)	2.48298848
95	pyrimidine nucleotide catabolic process (GO:0006244)	2.48104857
96	response to redox state (GO:0051775)	2.46901793
97	establishment of protein localization to mitochondrion (GO:0072655)	2.45691492
98	cytochrome complex assembly (GO:0017004)	2.45687650
99	regulation of cellular respiration (GO:0043457)	2.43967179
100	protein localization to membrane (GO:0072657)	2.43930125

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.37135708
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.73476904
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.29480284
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.03118066
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.90279830
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.75265370
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.74732211
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.42262589
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.33976413
10	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.25182452
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.25137542
12	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.19995266
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.16748507
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.16443235
15	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.09933313
16	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.03522488
17	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.94824884
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.87658766
19	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.86577326
20	VDR_22108803_ChIP-Seq_LS180_Human	1.84963670
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.83469556
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.75181445
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.67553647
24	EWS_26573619_Chip-Seq_HEK293_Human	1.66802722
25	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.65847153
26	ZNF274_21170338_ChIP-Seq_K562_Hela	1.64953163
27	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.64197859
28	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.64066095
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.63372790
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.61670251
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.53621386
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52998193
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.52895593
34	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.52860391
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49446174
36	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.49302575
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47297104
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.46335030
39	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.45580420
40	TTF2_22483619_ChIP-Seq_HELA_Human	1.41425308
41	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.39906640
42	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.36893927
43	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.35744715
44	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.34935790
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33983385
46	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.32786434
47	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.31138077
48	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.28324516
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.26066887
50	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.25790705
51	XRN2_22483619_ChIP-Seq_HELA_Human	1.23507985
52	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.23138141
53	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.21546436
54	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.21056656
55	P300_19829295_ChIP-Seq_ESCs_Human	1.20831510
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20779579
57	FOXP3_21729870_ChIP-Seq_TREG_Human	1.20153545
58	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20053410
59	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.19977071
60	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.19977071
61	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.18789429
62	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.18520740
63	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17183442
64	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.15731653
65	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.13459246
66	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11426890
67	FUS_26573619_Chip-Seq_HEK293_Human	1.09730804
68	GABP_19822575_ChIP-Seq_HepG2_Human	1.07958840
69	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.07772017
70	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.07216488
71	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.04776048
72	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.04064854
73	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.03456562
74	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03211630
75	ERA_21632823_ChIP-Seq_H3396_Human	1.02538707
76	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.02338397
77	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.01922248
78	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01329443
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00993609
80	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.00773830
81	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.99038290
82	NCOR_22424771_ChIP-Seq_293T_Human	0.98178357
83	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.98106918
84	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.97088772
85	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.96962975
86	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96893249
87	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.96660775
88	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.96226827
89	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95245753
90	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95245753
91	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.91855888
92	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.89590610
93	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.89109436
94	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.89005664
95	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.88593333
96	NANOG_19829295_ChIP-Seq_ESCs_Human	0.87892156
97	SOX2_19829295_ChIP-Seq_ESCs_Human	0.87892156
98	AR_20517297_ChIP-Seq_VCAP_Human	0.86842553
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.85987210
100	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.85568338

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.76008500
2	MP0006292_abnormal_olfactory_placode	5.02802091
3	MP0003787_abnormal_imprinting	2.91896049
4	MP0002102_abnormal_ear_morphology	2.74439651
5	MP0008789_abnormal_olfactory_epithelium	2.29501833
6	MP0008877_abnormal_DNA_methylation	2.24949480
7	MP0002163_abnormal_gland_morphology	2.20655069
8	MP0002638_abnormal_pupillary_reflex	2.18350896
9	MP0004142_abnormal_muscle_tone	2.15154076
10	MP0005499_abnormal_olfactory_system	2.02741592
11	MP0005394_taste/olfaction_phenotype	2.02741592
12	MP0003646_muscle_fatigue	2.00482634
13	MP0003122_maternal_imprinting	1.99109295
14	MP0004147_increased_porphyrin_level	1.94990311
15	MP0003880_abnormal_central_pattern	1.89526263
16	MP0003136_yellow_coat_color	1.87415682
17	MP0001293_anophthalmia	1.77930355
18	MP0002653_abnormal_ependyma_morphology	1.74839484
19	MP0003123_paternal_imprinting	1.67670227
20	MP0000049_abnormal_middle_ear	1.64624646
21	MP0001485_abnormal_pinna_reflex	1.61751071
22	MP0000778_abnormal_nervous_system	1.60008262
23	MP0006072_abnormal_retinal_apoptosis	1.57839408
24	MP0000372_irregular_coat_pigmentation	1.57138187
25	MP0001529_abnormal_vocalization	1.56710156
26	MP0003121_genomic_imprinting	1.56054541
27	MP0001968_abnormal_touch/_nociception	1.53814807
28	MP0002736_abnormal_nociception_after	1.50842208
29	MP0002938_white_spotting	1.49747697
30	MP0005551_abnormal_eye_electrophysiolog	1.49473401
31	MP0002272_abnormal_nervous_system	1.47364951
32	MP0006276_abnormal_autonomic_nervous	1.45789288
33	MP0000631_abnormal_neuroendocrine_gland	1.43795241
34	MP0005423_abnormal_somatic_nervous	1.43105117
35	MP0005084_abnormal_gallbladder_morpholo	1.41823120
36	MP0003011_delayed_dark_adaptation	1.39886023
37	MP0002837_dystrophic_cardiac_calcinosis	1.38636801
38	MP0004885_abnormal_endolymph	1.36593470
39	MP0005377_hearing/vestibular/ear_phenot	1.35885963
40	MP0003878_abnormal_ear_physiology	1.35885963
41	MP0003186_abnormal_redox_activity	1.34709439
42	MP0002234_abnormal_pharynx_morphology	1.32605186
43	MP0001984_abnormal_olfaction	1.29934510
44	MP0009745_abnormal_behavioral_response	1.28681028
45	MP0005195_abnormal_posterior_eye	1.28552224
46	MP0001970_abnormal_pain_threshold	1.26177382
47	MP0008872_abnormal_physiological_respon	1.25623292
48	MP0002095_abnormal_skin_pigmentation	1.25438266
49	MP0001905_abnormal_dopamine_level	1.22539117
50	MP0001188_hyperpigmentation	1.21220154
51	MP0002876_abnormal_thyroid_physiology	1.21206688
52	MP0000955_abnormal_spinal_cord	1.18690887
53	MP0005379_endocrine/exocrine_gland_phen	1.17687940
54	MP0002184_abnormal_innervation	1.16689849
55	MP0001440_abnormal_grooming_behavior	1.16364207
56	MP0000026_abnormal_inner_ear	1.15992634
57	MP0002752_abnormal_somatic_nervous	1.15756226
58	MP0005389_reproductive_system_phenotype	1.12559161
59	MP0002733_abnormal_thermal_nociception	1.09794648
60	MP0002160_abnormal_reproductive_system	1.09019746
61	MP0002138_abnormal_hepatobiliary_system	1.08705585
62	MP0002557_abnormal_social/conspecific_i	1.08433827
63	MP0005174_abnormal_tail_pigmentation	1.05676284
64	MP0001986_abnormal_taste_sensitivity	1.04214698
65	MP0005646_abnormal_pituitary_gland	1.03883466
66	MP0008775_abnormal_heart_ventricle	1.03343688
67	MP0003942_abnormal_urinary_system	1.02995591
68	MP0003938_abnormal_ear_development	1.00535376
69	MP0001286_abnormal_eye_development	0.98471355
70	MP0002277_abnormal_respiratory_mucosa	0.98185286
71	MP0001324_abnormal_eye_pigmentation	0.98159120
72	MP0000569_abnormal_digit_pigmentation	0.97789228
73	MP0004742_abnormal_vestibular_system	0.96755537
74	MP0004133_heterotaxia	0.96189477
75	MP0002572_abnormal_emotion/affect_behav	0.94738836
76	MP0002735_abnormal_chemical_nociception	0.93368249
77	MP0002734_abnormal_mechanical_nocicepti	0.92844370
78	MP0005645_abnormal_hypothalamus_physiol	0.92760876
79	MP0002063_abnormal_learning/memory/cond	0.92739460
80	MP0001502_abnormal_circadian_rhythm	0.92670481
81	MP0004145_abnormal_muscle_electrophysio	0.92353457
82	MP0008875_abnormal_xenobiotic_pharmacok	0.92087195
83	MP0002822_catalepsy	0.90437098
84	MP0003635_abnormal_synaptic_transmissio	0.88667351
85	MP0001486_abnormal_startle_reflex	0.88483478
86	MP0005253_abnormal_eye_physiology	0.88454425
87	MP0001919_abnormal_reproductive_system	0.87783354
88	MP0001963_abnormal_hearing_physiology	0.86831651
89	MP0009046_muscle_twitch	0.85341989
90	MP0002233_abnormal_nose_morphology	0.83711386
91	MP0002882_abnormal_neuron_morphology	0.80713013
92	MP0002067_abnormal_sensory_capabilities	0.80683255
93	MP0008995_early_reproductive_senescence	0.80502010
94	MP0009053_abnormal_anal_canal	0.80225277
95	MP0002064_seizures	0.79552575
96	MP0002928_abnormal_bile_duct	0.79337889
97	MP0002909_abnormal_adrenal_gland	0.79273971
98	MP0003937_abnormal_limbs/digits/tail_de	0.78975022
99	MP0002210_abnormal_sex_determination	0.78490620
100	MP0003879_abnormal_hair_cell	0.75524999

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.48233122
2	Acute necrotizing encephalopathy (HP:0006965)	4.79252468
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.41555586
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.29597114
5	Mitochondrial inheritance (HP:0001427)	4.13873289
6	Acute encephalopathy (HP:0006846)	4.08922787
7	Progressive macrocephaly (HP:0004481)	3.98988577
8	Macrocytic anemia (HP:0001972)	3.70093516
9	Increased CSF lactate (HP:0002490)	3.64314808
10	Septo-optic dysplasia (HP:0100842)	3.63877583
11	Molar tooth sign on MRI (HP:0002419)	3.60893332
12	Abnormality of midbrain morphology (HP:0002418)	3.60893332
13	Hepatocellular necrosis (HP:0001404)	3.38706206
14	Type II lissencephaly (HP:0007260)	3.27000747
15	Pallor (HP:0000980)	3.13394961
16	Pendular nystagmus (HP:0012043)	3.10546872
17	Abnormal number of erythroid precursors (HP:0012131)	3.07738681
18	Cerebral edema (HP:0002181)	3.07193188
19	Hepatic necrosis (HP:0002605)	3.01075930
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.88400186
21	Absent thumb (HP:0009777)	2.87739561
22	Pancreatic fibrosis (HP:0100732)	2.85118761
23	Stenosis of the external auditory canal (HP:0000402)	2.84056181
24	Pancreatic cysts (HP:0001737)	2.78276144
25	Nephronophthisis (HP:0000090)	2.73810905
26	Lipid accumulation in hepatocytes (HP:0006561)	2.73532734
27	Increased hepatocellular lipid droplets (HP:0006565)	2.70151642
28	Abnormality of the labia minora (HP:0012880)	2.57577815
29	Optic disc pallor (HP:0000543)	2.53507105
30	Optic nerve hypoplasia (HP:0000609)	2.50119108
31	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.50065152
32	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.50065152
33	Congenital stationary night blindness (HP:0007642)	2.48999397
34	3-Methylglutaconic aciduria (HP:0003535)	2.44159324
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.42477075
36	Absent/shortened dynein arms (HP:0200106)	2.42477075
37	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.42346578
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.37513200
39	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.33247004
40	Renal Fanconi syndrome (HP:0001994)	2.33056457
41	Medial flaring of the eyebrow (HP:0010747)	2.29603298
42	True hermaphroditism (HP:0010459)	2.26333429
43	Asplenia (HP:0001746)	2.25318649
44	Supernumerary spleens (HP:0009799)	2.21655374
45	Increased intramyocellular lipid droplets (HP:0012240)	2.20710392
46	Hypoplasia of the ulna (HP:0003022)	2.19686570
47	Increased serum lactate (HP:0002151)	2.17793427
48	Myokymia (HP:0002411)	2.17249880
49	Leukodystrophy (HP:0002415)	2.16712520
50	Abolished electroretinogram (ERG) (HP:0000550)	2.15798712
51	Depressed nasal ridge (HP:0000457)	2.15390397
52	Hyperglycinemia (HP:0002154)	2.13323038
53	Rib fusion (HP:0000902)	2.11560992
54	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.08152440
55	Adrenal hypoplasia (HP:0000835)	2.07340394
56	Hypoplasia of the radius (HP:0002984)	2.06577479
57	Abnormality of magnesium homeostasis (HP:0004921)	2.06057706
58	Lactic acidosis (HP:0003128)	2.02435007
59	Abnormal respiratory epithelium morphology (HP:0012253)	2.00096908
60	Abnormal respiratory motile cilium morphology (HP:0005938)	2.00096908
61	Abnormal hemoglobin (HP:0011902)	1.99008359
62	Respiratory failure (HP:0002878)	1.98416507
63	Maternal diabetes (HP:0009800)	1.97786283
64	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.97446534
65	Abnormality of the renal medulla (HP:0100957)	1.96770033
66	Hypoplasia of the pons (HP:0012110)	1.96531026
67	Growth hormone deficiency (HP:0000824)	1.96061100
68	Forearm undergrowth (HP:0009821)	1.95962765
69	Absent septum pellucidum (HP:0001331)	1.95666350
70	Tubular atrophy (HP:0000092)	1.95351260
71	Cerebellar dysplasia (HP:0007033)	1.94473671
72	Anencephaly (HP:0002323)	1.94147454
73	Sclerocornea (HP:0000647)	1.92992262
74	Partial duplication of thumb phalanx (HP:0009944)	1.92422898
75	Horseshoe kidney (HP:0000085)	1.91755838
76	Increased muscle lipid content (HP:0009058)	1.91299707
77	Microretrognathia (HP:0000308)	1.91059141
78	Lissencephaly (HP:0001339)	1.89838418
79	Keratoconus (HP:0000563)	1.87999932
80	Increased corneal curvature (HP:0100692)	1.87999932
81	Abnormal ciliary motility (HP:0012262)	1.87733972
82	Partial duplication of the phalanx of hand (HP:0009999)	1.87193030
83	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.86848909
84	Oligodactyly (hands) (HP:0001180)	1.85178480
85	Lethargy (HP:0001254)	1.84444694
86	Exertional dyspnea (HP:0002875)	1.84287240
87	Exercise intolerance (HP:0003546)	1.84242563
88	Gait imbalance (HP:0002141)	1.82781331
89	Abnormality of the pons (HP:0007361)	1.81999847
90	Decreased central vision (HP:0007663)	1.81884962
91	Cystic liver disease (HP:0006706)	1.81828948
92	Abnormality of DNA repair (HP:0003254)	1.81129999
93	Anophthalmia (HP:0000528)	1.78958841
94	Triphalangeal thumb (HP:0001199)	1.75168531
95	Oligodactyly (HP:0012165)	1.74691382
96	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.73301085
97	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.73301085
98	Congenital primary aphakia (HP:0007707)	1.73011009
99	Postaxial foot polydactyly (HP:0001830)	1.72694878
100	X-linked dominant inheritance (HP:0001423)	1.72378586

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.31169282
2	WNK4	2.89766387
3	NME2	2.78653209
4	BCKDK	2.56120930
5	ADRBK2	2.46606103
6	PIK3CA	2.36069831
7	CDK19	2.33753598
8	DYRK2	2.27747921
9	MAP3K12	2.24782652
10	GRK1	2.22209072
11	WNK3	2.16003379
12	FRK	2.14659394
13	EPHA4	2.09935638
14	VRK2	1.92801084
15	TLK1	1.92386723
16	LRRK2	1.79895038
17	EPHB2	1.74830464
18	ZAK	1.72529855
19	TRIM28	1.69649587
20	STK39	1.67859861
21	TIE1	1.62696972
22	CASK	1.58420408
23	MAP2K7	1.47228177
24	NUAK1	1.46684361
25	NEK1	1.45478039
26	PLK4	1.40805356
27	PDK2	1.32378315
28	INSRR	1.32142780
29	TNIK	1.27254857
30	DAPK3	1.23057498
31	PINK1	1.21402554
32	NTRK3	1.18867112
33	TYRO3	1.18681707
34	BRAF	1.17747514
35	WNK1	1.15105968
36	CAMK1D	1.14431589
37	OXSR1	1.12025869
38	PRKCG	1.11448835
39	BMPR1B	1.08774179
40	MAP3K4	1.02179447
41	CDC7	1.01700387
42	MAP4K2	0.98835787
43	MAP3K9	0.98770216
44	NTRK2	0.97505766
45	MAPK13	0.96178102
46	NME1	0.93411035
47	CAMK1	0.91509415
48	CAMKK2	0.89699495
49	PAK3	0.87030678
50	DMPK	0.86335302
51	PASK	0.86320834
52	WEE1	0.85805677
53	ADRBK1	0.85699427
54	PLK2	0.79314943
55	AURKB	0.78116901
56	NEK2	0.78076711
57	VRK1	0.76432518
58	ACVR1B	0.76035704
59	DYRK3	0.72365478
60	MINK1	0.70255197
61	ARAF	0.69588171
62	MARK1	0.67443800
63	CSNK2A2	0.65306720
64	DAPK2	0.61801097
65	PRKCH	0.60172521
66	PRKACA	0.58967002
67	PLK1	0.58440064
68	PHKG1	0.58186614
69	PHKG2	0.58186614
70	MYLK	0.58036777
71	TXK	0.57107451
72	ILK	0.56802726
73	PLK3	0.56612969
74	PIM2	0.55694928
75	LIMK1	0.54550738
76	STK11	0.54288789
77	CSNK1E	0.53477385
78	IKBKB	0.53092790
79	MAP2K4	0.51051286
80	GRK5	0.50795231
81	PRKCQ	0.49358082
82	GRK7	0.47710240
83	MUSK	0.47396038
84	AURKA	0.46426286
85	CAMK1G	0.44904550
86	ABL2	0.44087128
87	CSNK2A1	0.44020010
88	CHEK2	0.43362984
89	SGK494	0.42886416
90	SGK223	0.42886416
91	ERBB2	0.42553644
92	MAP3K11	0.42409450
93	PRKCI	0.42246365
94	CAMK2A	0.42188735
95	SGK1	0.42012193
96	CDK8	0.41616336
97	TGFBR1	0.41252787
98	CSNK1G2	0.40693074
99	OBSCN	0.40458812
100	RPS6KA6	0.39095804

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.58881443
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.81060046
3	Parkinsons disease_Homo sapiens_hsa05012	4.07019172
4	Huntingtons disease_Homo sapiens_hsa05016	3.04052871
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.88937953
6	Sulfur relay system_Homo sapiens_hsa04122	2.84247457
7	Alzheimers disease_Homo sapiens_hsa05010	2.80421176
8	Proteasome_Homo sapiens_hsa03050	2.78395296
9	Protein export_Homo sapiens_hsa03060	2.71214656
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.55564525
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.29889951
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.27900876
13	RNA polymerase_Homo sapiens_hsa03020	2.24825761
14	Asthma_Homo sapiens_hsa05310	1.92618046
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.80298993
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.75438575
17	RNA degradation_Homo sapiens_hsa03018	1.62614538
18	Homologous recombination_Homo sapiens_hsa03440	1.51158417
19	Nicotine addiction_Homo sapiens_hsa05033	1.34239814
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.33164350
21	Basal transcription factors_Homo sapiens_hsa03022	1.29811302
22	One carbon pool by folate_Homo sapiens_hsa00670	1.26083294
23	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.24709837
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.22506096
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.19574149
26	Propanoate metabolism_Homo sapiens_hsa00640	1.18711875
27	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.08257278
28	Butanoate metabolism_Homo sapiens_hsa00650	1.06106565
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.04695742
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.04339819
31	Phototransduction_Homo sapiens_hsa04744	1.03481713
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.02694212
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.93156347
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.90814906
35	Tryptophan metabolism_Homo sapiens_hsa00380	0.90508532
36	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.87079568
37	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.86332732
38	Basal cell carcinoma_Homo sapiens_hsa05217	0.85076897
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.78135792
40	Peroxisome_Homo sapiens_hsa04146	0.72754355
41	Allograft rejection_Homo sapiens_hsa05330	0.72693532
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71900261
43	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.71464452
44	Mismatch repair_Homo sapiens_hsa03430	0.66472765
45	Metabolic pathways_Homo sapiens_hsa01100	0.65705635
46	Spliceosome_Homo sapiens_hsa03040	0.64243503
47	Morphine addiction_Homo sapiens_hsa05032	0.63939249
48	Caffeine metabolism_Homo sapiens_hsa00232	0.63233939
49	RNA transport_Homo sapiens_hsa03013	0.63123674
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.62458355
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62437722
52	Purine metabolism_Homo sapiens_hsa00230	0.60421361
53	Olfactory transduction_Homo sapiens_hsa04740	0.58748499
54	Nitrogen metabolism_Homo sapiens_hsa00910	0.58468750
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58055904
56	Fat digestion and absorption_Homo sapiens_hsa04975	0.56880772
57	Insulin secretion_Homo sapiens_hsa04911	0.56705011
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.55769488
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55549517
60	Folate biosynthesis_Homo sapiens_hsa00790	0.54306991
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54299341
62	Retinol metabolism_Homo sapiens_hsa00830	0.54210539
63	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.53520927
64	Fatty acid degradation_Homo sapiens_hsa00071	0.51756652
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51039702
66	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.49234618
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47748211
68	GABAergic synapse_Homo sapiens_hsa04727	0.46976707
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43861828
70	Taste transduction_Homo sapiens_hsa04742	0.43794641
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41535681
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.41208119
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.41037176
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.40977907
75	Steroid biosynthesis_Homo sapiens_hsa00100	0.38176936
76	DNA replication_Homo sapiens_hsa03030	0.37624028
77	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.36151333
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.35452499
79	Serotonergic synapse_Homo sapiens_hsa04726	0.34334175
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.34189687
81	Base excision repair_Homo sapiens_hsa03410	0.32744650
82	Type I diabetes mellitus_Homo sapiens_hsa04940	0.31093536
83	Hippo signaling pathway_Homo sapiens_hsa04390	0.30834308
84	Rheumatoid arthritis_Homo sapiens_hsa05323	0.30699814
85	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.28992947
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.27619947
87	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.26167051
88	p53 signaling pathway_Homo sapiens_hsa04115	0.25952391
89	Cholinergic synapse_Homo sapiens_hsa04725	0.25470648
90	Graft-versus-host disease_Homo sapiens_hsa05332	0.24714600
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.24058665
92	Dopaminergic synapse_Homo sapiens_hsa04728	0.21631816
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.19887581
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.19713207
95	Circadian entrainment_Homo sapiens_hsa04713	0.19507643
96	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.19255873
97	Wnt signaling pathway_Homo sapiens_hsa04310	0.19116245
98	Axon guidance_Homo sapiens_hsa04360	0.18232143
99	Regulation of autophagy_Homo sapiens_hsa04140	0.17442165
100	Primary immunodeficiency_Homo sapiens_hsa05340	0.16855631

RPL17P26

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »