RPL17P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)8.29393717
2ribosomal small subunit assembly (GO:0000028)8.27682249
3ribosomal small subunit biogenesis (GO:0042274)7.83857460
4viral transcription (GO:0019083)7.68132836
5translational termination (GO:0006415)7.39544447
6translational elongation (GO:0006414)6.25663790
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.18130391
8cotranslational protein targeting to membrane (GO:0006613)6.10205693
9protein targeting to ER (GO:0045047)6.10184588
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.86750674
11protein localization to endoplasmic reticulum (GO:0070972)5.71355892
12cellular protein complex disassembly (GO:0043624)5.62181077
13viral life cycle (GO:0019058)5.56971935
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.49475120
15translational initiation (GO:0006413)5.02319171
16ribosomal large subunit biogenesis (GO:0042273)4.93010300
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.90146815
18protein complex disassembly (GO:0043241)4.76157336
19epithelial cilium movement (GO:0003351)4.69055945
20macromolecular complex disassembly (GO:0032984)4.55083572
21energy coupled proton transport, down electrochemical gradient (GO:0015985)4.54527824
22ATP synthesis coupled proton transport (GO:0015986)4.54527824
23chaperone-mediated protein transport (GO:0072321)4.46061264
24protein targeting to membrane (GO:0006612)4.23539119
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.17062576
26negative regulation of telomere maintenance (GO:0032205)4.11360217
27positive regulation of respiratory burst (GO:0060267)4.08258572
28nuclear-transcribed mRNA catabolic process (GO:0000956)4.02350564
29nonmotile primary cilium assembly (GO:0035058)3.98313037
30mRNA catabolic process (GO:0006402)3.86779063
31negative regulation of execution phase of apoptosis (GO:1900118)3.84568471
32substrate-independent telencephalic tangential migration (GO:0021826)3.79198227
33substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.79198227
34somite development (GO:0061053)3.76389216
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.75131622
36tongue development (GO:0043586)3.74604879
37translation (GO:0006412)3.68121609
38sperm motility (GO:0030317)3.67133493
39peptidyl-histidine modification (GO:0018202)3.62469732
40cilium movement (GO:0003341)3.59622468
41fusion of sperm to egg plasma membrane (GO:0007342)3.58213970
42acrosome reaction (GO:0007340)3.55032318
43axonemal dynein complex assembly (GO:0070286)3.51758203
44RNA catabolic process (GO:0006401)3.47031325
45regulation of cilium movement (GO:0003352)3.36790357
46myoblast migration (GO:0051451)3.35922827
47left/right axis specification (GO:0070986)3.31037754
48ribonucleoprotein complex biogenesis (GO:0022613)3.30120830
49piRNA metabolic process (GO:0034587)3.27794504
50regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27688374
51cell proliferation in forebrain (GO:0021846)3.23999469
52protein complex biogenesis (GO:0070271)3.08728661
53cellular component biogenesis (GO:0044085)3.08389863
54mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07465691
55pyrimidine nucleobase catabolic process (GO:0006208)3.07178343
56respiratory electron transport chain (GO:0022904)3.06881891
57motile cilium assembly (GO:0044458)3.02448521
58hydrogen ion transmembrane transport (GO:1902600)3.01251798
59pattern specification involved in kidney development (GO:0061004)3.00103677
60NADH dehydrogenase complex assembly (GO:0010257)2.99924530
61mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99924530
62mitochondrial respiratory chain complex I assembly (GO:0032981)2.99924530
63electron transport chain (GO:0022900)2.99221058
64behavioral response to nicotine (GO:0035095)2.98220929
65negative regulation of heart rate (GO:0010459)2.97882490
66ATP biosynthetic process (GO:0006754)2.95003380
67DNA strand renaturation (GO:0000733)2.88445941
68cardiovascular system development (GO:0072358)2.88089671
69positive regulation of defense response to virus by host (GO:0002230)2.84593005
70protein neddylation (GO:0045116)2.84126176
71spermatid development (GO:0007286)2.83537438
72plasma membrane fusion (GO:0045026)2.79067386
73purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.76335261
74establishment of protein localization to membrane (GO:0090150)2.76136960
75protein targeting (GO:0006605)2.75459379
76cellular ketone body metabolic process (GO:0046950)2.74605552
77positive regulation of T cell apoptotic process (GO:0070234)2.72348910
78purine nucleoside triphosphate biosynthetic process (GO:0009145)2.71755819
79thyroid hormone generation (GO:0006590)2.71675648
80regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.67154707
81regulation of action potential (GO:0098900)2.65690359
82mitochondrial respiratory chain complex assembly (GO:0033108)2.64865626
83postsynaptic membrane organization (GO:0001941)2.63584911
84behavioral response to ethanol (GO:0048149)2.63580597
85proton transport (GO:0015992)2.63295150
86regulation of telomere maintenance (GO:0032204)2.62182706
87serine family amino acid catabolic process (GO:0009071)2.61367488
88protein polyglutamylation (GO:0018095)2.59915089
89UTP metabolic process (GO:0046051)2.59356852
90collecting duct development (GO:0072044)2.58157940
91neurotransmitter catabolic process (GO:0042135)2.56964863
92negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.56861765
93hydrogen transport (GO:0006818)2.56024530
94DNA deamination (GO:0045006)2.54570628
95synapsis (GO:0007129)2.53300994
96sperm capacitation (GO:0048240)2.50950049
97ketone body metabolic process (GO:1902224)2.50440733
98ventricular system development (GO:0021591)2.50030374
99forebrain neuron differentiation (GO:0021879)2.49213889
100establishment of mitochondrion localization (GO:0051654)2.45670646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.20053710
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.81649858
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.23965906
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.51478118
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.03368107
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.67002982
7VDR_22108803_ChIP-Seq_LS180_Human2.42124529
8ZNF274_21170338_ChIP-Seq_K562_Hela2.37089211
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20143024
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14488863
11IRF1_19129219_ChIP-ChIP_H3396_Human2.13919716
12EST1_17652178_ChIP-ChIP_JURKAT_Human1.97689251
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97199465
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.86031372
15ETS1_20019798_ChIP-Seq_JURKAT_Human1.84931101
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75718920
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73143808
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.63654044
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63070202
20RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.58231399
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54852440
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54844753
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49455105
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.48264705
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47713069
26TDRD3_21172665_ChIP-Seq_MCF-7_Human1.45227935
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43581765
28ETV2_25802403_ChIP-Seq_MESCs_Mouse1.43536084
29GATA3_21878914_ChIP-Seq_MCF-7_Human1.43260793
30TP53_22573176_ChIP-Seq_HFKS_Human1.40910813
31REST_21632747_ChIP-Seq_MESCs_Mouse1.39990130
32MYC_18940864_ChIP-ChIP_HL60_Human1.38879145
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.32936050
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.32280241
35FUS_26573619_Chip-Seq_HEK293_Human1.29958222
36SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27900383
37PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26915425
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26316585
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26191247
40ERA_21632823_ChIP-Seq_H3396_Human1.24481335
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24245372
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23764681
43P300_19829295_ChIP-Seq_ESCs_Human1.23488176
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22893022
45YY1_22570637_ChIP-Seq_MALME-3M_Human1.22262488
46TAF2_19829295_ChIP-Seq_ESCs_Human1.20890415
47EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.20867127
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20179238
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.17245880
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.16808330
51NANOG_20526341_ChIP-Seq_ESCs_Human1.16754287
52VDR_23849224_ChIP-Seq_CD4+_Human1.16548646
53ERG_20517297_ChIP-Seq_VCAP_Human1.16368541
54SOX2_16153702_ChIP-ChIP_HESCs_Human1.15423559
55RNF2_27304074_Chip-Seq_NSC_Mouse1.15393939
56TP53_20018659_ChIP-ChIP_R1E_Mouse1.14866711
57E2F1_20622854_ChIP-Seq_HELA_Human1.12291835
58MYC_19829295_ChIP-Seq_ESCs_Human1.11438480
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07920383
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.07884789
61RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07430889
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.06667373
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06503208
64GBX2_23144817_ChIP-Seq_PC3_Human1.06309284
65FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06091613
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06003469
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04729321
68TTF2_22483619_ChIP-Seq_HELA_Human1.03436694
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.03088885
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03078701
71CBP_20019798_ChIP-Seq_JUKART_Human1.01747778
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01747778
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01316351
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01073351
75RAC3_21632823_ChIP-Seq_H3396_Human1.00857705
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00489698
77SMAD3_21741376_ChIP-Seq_ESCs_Human0.99072519
78CTCF_20526341_ChIP-Seq_ESCs_Human0.96182076
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96113425
80NCOR_22424771_ChIP-Seq_293T_Human0.95904922
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95522648
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94651454
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94326973
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94326973
85JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94209690
86E2F1_17053090_ChIP-ChIP_MCF-7_Human0.91978470
87CTCF_27219007_Chip-Seq_Bcells_Human0.90613304
88OCT4_19829295_ChIP-Seq_ESCs_Human0.89511440
89ELF1_20517297_ChIP-Seq_JURKAT_Human0.89318974
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87853252
91SMAD4_21741376_ChIP-Seq_EPCs_Human0.87133020
92FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87022520
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.87022520
94HOXB7_26014856_ChIP-Seq_BT474_Human0.86968278
95FOXH1_21741376_ChIP-Seq_ESCs_Human0.86297413
96P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.83537693
97FOXP1_21924763_ChIP-Seq_HESCs_Human0.83304285
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82779330
99RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.81985776
100BCAT_22108803_ChIP-Seq_LS180_Human0.81944774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.11475030
2MP0006292_abnormal_olfactory_placode3.85635731
3MP0003646_muscle_fatigue3.02247668
4MP0003136_yellow_coat_color2.92324456
5MP0003878_abnormal_ear_physiology2.75108730
6MP0005377_hearing/vestibular/ear_phenot2.75108730
7MP0008877_abnormal_DNA_methylation2.35214671
8MP0003122_maternal_imprinting2.34729462
9MP0005423_abnormal_somatic_nervous2.27791901
10MP0001485_abnormal_pinna_reflex2.16389037
11MP0005410_abnormal_fertilization2.14193532
12MP0002735_abnormal_chemical_nociception2.02849172
13MP0003787_abnormal_imprinting1.94319329
14MP0004742_abnormal_vestibular_system1.87289577
15MP0010030_abnormal_orbit_morphology1.80543002
16MP0001968_abnormal_touch/_nociception1.79087935
17MP0002277_abnormal_respiratory_mucosa1.77284861
18MP0001293_anophthalmia1.76858499
19MP0003880_abnormal_central_pattern1.76422557
20MP0008789_abnormal_olfactory_epithelium1.73949351
21MP0002102_abnormal_ear_morphology1.68843429
22MP0002736_abnormal_nociception_after1.59275144
23MP0004142_abnormal_muscle_tone1.59167941
24MP0000049_abnormal_middle_ear1.56931544
25MP0005645_abnormal_hypothalamus_physiol1.55259101
26MP0003121_genomic_imprinting1.54792520
27MP0004885_abnormal_endolymph1.54009848
28MP0006276_abnormal_autonomic_nervous1.52740502
29MP0005499_abnormal_olfactory_system1.49862745
30MP0005394_taste/olfaction_phenotype1.49862745
31MP0003938_abnormal_ear_development1.49714437
32MP0000778_abnormal_nervous_system1.48663522
33MP0002938_white_spotting1.46203410
34MP0004145_abnormal_muscle_electrophysio1.44288642
35MP0003011_delayed_dark_adaptation1.43159148
36MP0004859_abnormal_synaptic_plasticity1.39684429
37MP0002272_abnormal_nervous_system1.38477766
38MP0002876_abnormal_thyroid_physiology1.37356519
39MP0001984_abnormal_olfaction1.33833652
40MP0000566_synostosis1.33439997
41MP0002095_abnormal_skin_pigmentation1.30402801
42MP0002184_abnormal_innervation1.28969381
43MP0001348_abnormal_lacrimal_gland1.27505816
44MP0003698_abnormal_male_reproductive1.24998129
45MP0001986_abnormal_taste_sensitivity1.22871122
46MP0005174_abnormal_tail_pigmentation1.22288733
47MP0001905_abnormal_dopamine_level1.19484932
48MP0001970_abnormal_pain_threshold1.18774046
49MP0002734_abnormal_mechanical_nocicepti1.18099078
50MP0002733_abnormal_thermal_nociception1.16693266
51MP0005084_abnormal_gallbladder_morpholo1.15970655
52MP0005551_abnormal_eye_electrophysiolog1.10708687
53MP0000026_abnormal_inner_ear1.09854642
54MP0003879_abnormal_hair_cell1.09627509
55MP0002638_abnormal_pupillary_reflex1.08662523
56MP0003195_calcinosis1.07017944
57MP0002837_dystrophic_cardiac_calcinosis1.06888770
58MP0002127_abnormal_cardiovascular_syste1.04720058
59MP0001929_abnormal_gametogenesis1.02644504
60MP0001963_abnormal_hearing_physiology0.99682548
61MP0002752_abnormal_somatic_nervous0.98758928
62MP0009745_abnormal_behavioral_response0.98409611
63MP0002282_abnormal_trachea_morphology0.97173184
64MP0002063_abnormal_learning/memory/cond0.96185153
65MP0000955_abnormal_spinal_cord0.95549709
66MP0001486_abnormal_startle_reflex0.94670918
67MP0003635_abnormal_synaptic_transmissio0.94128025
68MP0002210_abnormal_sex_determination0.93853082
69MP0002572_abnormal_emotion/affect_behav0.93464697
70MP0002249_abnormal_larynx_morphology0.93137305
71MP0003186_abnormal_redox_activity0.91424864
72MP0005408_hypopigmentation0.90492592
73MP0002557_abnormal_social/conspecific_i0.90287849
74MP0005195_abnormal_posterior_eye0.88287565
75MP0005332_abnormal_amino_acid0.86953551
76MP0008875_abnormal_xenobiotic_pharmacok0.85983074
77MP0002138_abnormal_hepatobiliary_system0.85240674
78MP0002653_abnormal_ependyma_morphology0.84753226
79MP0002163_abnormal_gland_morphology0.83768662
80MP0002822_catalepsy0.82963925
81MP0002161_abnormal_fertility/fecundity0.81771114
82MP0000230_abnormal_systemic_arterial0.81363921
83MP0003942_abnormal_urinary_system0.80530567
84MP0001440_abnormal_grooming_behavior0.78728312
85MP0002067_abnormal_sensory_capabilities0.77129882
86MP0002233_abnormal_nose_morphology0.75684496
87MP0003119_abnormal_digestive_system0.75305847
88MP0000647_abnormal_sebaceous_gland0.75194544
89MP0008872_abnormal_physiological_respon0.74929629
90MP0006035_abnormal_mitochondrial_morpho0.74835417
91MP0008995_early_reproductive_senescence0.72267780
92MP0005083_abnormal_biliary_tract0.71865412
93MP0003123_paternal_imprinting0.70528058
94MP0002132_abnormal_respiratory_system0.70387957
95MP0000631_abnormal_neuroendocrine_gland0.70152063
96MP0004133_heterotaxia0.69335802
97MP0002882_abnormal_neuron_morphology0.68021904
98MP0001764_abnormal_homeostasis0.67665851
99MP0001286_abnormal_eye_development0.65215082
100MP0002064_seizures0.64557102

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.22015457
2Aplasia/Hypoplasia of the sacrum (HP:0008517)5.15594598
3Abnormality of cells of the erythroid lineage (HP:0012130)4.77244300
4Colon cancer (HP:0003003)4.31671978
5Rib fusion (HP:0000902)4.28769965
6Macrocytic anemia (HP:0001972)4.26992620
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.80450486
8Absent/shortened dynein arms (HP:0200106)3.80450486
9Nephronophthisis (HP:0000090)3.77323862
10Abnormal number of erythroid precursors (HP:0012131)3.53259644
11Acute necrotizing encephalopathy (HP:0006965)3.33858767
12Abnormality of midbrain morphology (HP:0002418)3.28103234
13Molar tooth sign on MRI (HP:0002419)3.28103234
14Pallor (HP:0000980)3.24033688
15Septo-optic dysplasia (HP:0100842)3.16515246
16Tubulointerstitial nephritis (HP:0001970)3.09347868
17Decreased central vision (HP:0007663)3.04851298
18Abnormality of the diencephalon (HP:0010662)3.01377010
19Mitochondrial inheritance (HP:0001427)2.99065966
20Hepatic necrosis (HP:0002605)2.93700056
21Stenosis of the external auditory canal (HP:0000402)2.91194213
22Hepatocellular necrosis (HP:0001404)2.90000281
23Abnormality of the renal medulla (HP:0100957)2.82827315
24Abnormal mitochondria in muscle tissue (HP:0008316)2.82145521
25Absent thumb (HP:0009777)2.74640304
26Atonic seizures (HP:0010819)2.72811114
27Acute encephalopathy (HP:0006846)2.70189277
2811 pairs of ribs (HP:0000878)2.68521328
29Tubular atrophy (HP:0000092)2.63357426
30Increased CSF lactate (HP:0002490)2.62066526
31Thyroid-stimulating hormone excess (HP:0002925)2.59339393
32Progressive macrocephaly (HP:0004481)2.57678183
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.57653457
34Abnormal rod and cone electroretinograms (HP:0008323)2.56738340
35Abnormal respiratory epithelium morphology (HP:0012253)2.53523423
36Abnormal respiratory motile cilium morphology (HP:0005938)2.53523423
37Missing ribs (HP:0000921)2.53032647
38Congenital stationary night blindness (HP:0007642)2.44175686
39Renal Fanconi syndrome (HP:0001994)2.38824297
40Abnormal ciliary motility (HP:0012262)2.38320467
41Partial duplication of thumb phalanx (HP:0009944)2.34212231
42Maternal diabetes (HP:0009800)2.31477275
43Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.29074261
44Abnormality of homocysteine metabolism (HP:0010919)2.26502438
45Homocystinuria (HP:0002156)2.26502438
46Abnormality of the phalanges of the 5th finger (HP:0004213)2.26497273
47Cerebral edema (HP:0002181)2.26462671
48Abnormal number of incisors (HP:0011064)2.26282179
49Abnormal respiratory motile cilium physiology (HP:0012261)2.24341906
50Pancreatic fibrosis (HP:0100732)2.23070882
51Adrenal hypoplasia (HP:0000835)2.20583505
52Abolished electroretinogram (ERG) (HP:0000550)2.20408906
53Anophthalmia (HP:0000528)2.19781745
54Symphalangism affecting the phalanges of the hand (HP:0009773)2.19498706
55Supernumerary spleens (HP:0009799)2.19432042
56Increased hepatocellular lipid droplets (HP:0006565)2.19384935
57Absent septum pellucidum (HP:0001331)2.19124961
58Renovascular hypertension (HP:0100817)2.18591467
59Flat capital femoral epiphysis (HP:0003370)2.18186801
60Small hand (HP:0200055)2.17497171
61Chorioretinal atrophy (HP:0000533)2.15672425
62Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12938262
63Polyphagia (HP:0002591)2.12791158
64Concave nail (HP:0001598)2.12595403
65Chronic sinusitis (HP:0011109)2.11700590
66Renal duplication (HP:0000075)2.10809996
67Depressed nasal ridge (HP:0000457)2.08179497
68Abnormality of reticulocytes (HP:0004312)2.06953311
69Abnormality of the labia minora (HP:0012880)2.04011370
70Optic nerve hypoplasia (HP:0000609)2.00636441
71Sclerocornea (HP:0000647)2.00328879
72Type 2 muscle fiber atrophy (HP:0003554)1.98424479
73Lipid accumulation in hepatocytes (HP:0006561)1.97921400
74Bony spicule pigmentary retinopathy (HP:0007737)1.96314876
75Optic disc pallor (HP:0000543)1.95785938
76Hip dysplasia (HP:0001385)1.94938341
77Pendular nystagmus (HP:0012043)1.92828311
78Chronic bronchitis (HP:0004469)1.91342158
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91030794
80Generalized aminoaciduria (HP:0002909)1.90740001
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89686847
82Glycosuria (HP:0003076)1.87993045
83Abnormality of urine glucose concentration (HP:0011016)1.87993045
84Partial duplication of the phalanx of hand (HP:0009999)1.86767639
85Muscle fiber atrophy (HP:0100295)1.85459450
86Increased serum lactate (HP:0002151)1.83997359
87Hyperthyroidism (HP:0000836)1.83496042
88Supernumerary bones of the axial skeleton (HP:0009144)1.82856419
89Abnormal hemoglobin (HP:0011902)1.82542360
90Supernumerary ribs (HP:0005815)1.81537476
91Severe visual impairment (HP:0001141)1.80707750
92Hypothermia (HP:0002045)1.79113542
93Lethargy (HP:0001254)1.78942944
94Abnormality of renal resorption (HP:0011038)1.77042581
95Myokymia (HP:0002411)1.74790767
96Pancreatic cysts (HP:0001737)1.71673694
97Anencephaly (HP:0002323)1.70451363
98Vertebral hypoplasia (HP:0008417)1.69397815
99Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.69397815
100Rhinitis (HP:0012384)1.69380368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.15216144
2WNK43.55766559
3PINK12.82692731
4CDK192.77181699
5STK392.55978509
6BCKDK2.21943900
7TAF12.12281167
8LRRK22.08299086
9VRK12.04414778
10MAP3K91.99143661
11CAMK1D1.95960113
12ADRBK21.88813286
13CDC71.88561476
14CAMK11.76809031
15DYRK21.76740525
16GRK11.68176661
17MAP4K21.65291814
18FRK1.58461992
19CASK1.56692174
20SMG11.53617706
21NUAK11.52449195
22CAMK1G1.49966426
23INSRR1.41476326
24ZAK1.34188463
25WNK31.29933466
26PASK1.29333799
27NME21.26651583
28PRKCG1.25626700
29CAMKK11.24897432
30PLK41.24839281
31PRKCH1.23529424
32EPHB21.16418942
33PAK31.16390209
34PRKD31.13163510
35NTRK21.12837867
36WNK11.11134322
37PIK3CA1.08281983
38AKT31.07328078
39MKNK21.06746053
40BMPR21.06465324
41OXSR10.96449035
42TLK10.96198560
43PDK20.88773830
44EPHA40.85446941
45CSNK1E0.85263696
46CSNK1G30.84725532
47TNIK0.82680176
48MAPKAPK50.79636702
49CSNK1G10.78534917
50MAP3K40.76385651
51CAMKK20.73918560
52MAPK150.73102023
53MAP3K110.72694047
54PAK20.71694294
55DAPK30.71096056
56BRAF0.69956397
57PLK10.69313810
58CSNK1G20.67154447
59TXK0.66598493
60NME10.66159026
61SGK30.65139210
62PNCK0.63213340
63CSNK2A20.61338671
64AURKB0.61264419
65PRKACA0.61114932
66CCNB10.61039825
67GRK50.59708179
68ADRBK10.59515479
69CSNK1A1L0.58430938
70MINK10.58423016
71PRKAA20.57329113
72MUSK0.56700748
73MAP2K70.55413724
74MKNK10.54121830
75MAP3K120.53934505
76STK160.52770379
77BMPR1B0.51491103
78MARK10.51064751
79STK40.49490129
80MAPK130.47117279
81KIT0.46972862
82CHEK10.46572398
83STK380.44471645
84MAP2K40.44266574
85PRKCQ0.43965261
86ILK0.43582744
87CHEK20.42824259
88WEE10.42641845
89LIMK10.41121843
90SGK4940.40163583
91SGK2230.40163583
92STK110.40087639
93CAMK2A0.39640464
94PRKCD0.39252971
95ALK0.39086356
96ATR0.38964203
97PRKCE0.37873492
98NTRK30.37713537
99RPS6KA20.37339563
100PRKCA0.36582964

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.61771371
2Oxidative phosphorylation_Homo sapiens_hsa001903.96044953
3Parkinsons disease_Homo sapiens_hsa050123.31624959
4Cardiac muscle contraction_Homo sapiens_hsa042603.14198941
5Huntingtons disease_Homo sapiens_hsa050162.56402662
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.46692159
7Alzheimers disease_Homo sapiens_hsa050102.15842004
8Sulfur relay system_Homo sapiens_hsa041222.06072983
9One carbon pool by folate_Homo sapiens_hsa006702.05034097
10RNA degradation_Homo sapiens_hsa030182.01147581
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98699387
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96254532
13Homologous recombination_Homo sapiens_hsa034401.82424382
14Proteasome_Homo sapiens_hsa030501.74241578
15Protein export_Homo sapiens_hsa030601.69783655
16Asthma_Homo sapiens_hsa053101.63961352
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50608576
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.48540384
19Propanoate metabolism_Homo sapiens_hsa006401.42128953
20Nicotine addiction_Homo sapiens_hsa050331.41665004
21Autoimmune thyroid disease_Homo sapiens_hsa053201.29658592
22Butanoate metabolism_Homo sapiens_hsa006501.27996409
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26844477
24Linoleic acid metabolism_Homo sapiens_hsa005911.26258087
25RNA polymerase_Homo sapiens_hsa030201.24923162
26Peroxisome_Homo sapiens_hsa041461.21871438
27Olfactory transduction_Homo sapiens_hsa047401.15027845
28Allograft rejection_Homo sapiens_hsa053301.14260093
29Base excision repair_Homo sapiens_hsa034101.12348492
30Taste transduction_Homo sapiens_hsa047421.11355565
31beta-Alanine metabolism_Homo sapiens_hsa004101.10391061
32Graft-versus-host disease_Homo sapiens_hsa053321.09844471
33Tryptophan metabolism_Homo sapiens_hsa003801.08017368
34Type I diabetes mellitus_Homo sapiens_hsa049401.07243824
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.03512320
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01051266
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00613970
38Phototransduction_Homo sapiens_hsa047440.99479572
39Selenocompound metabolism_Homo sapiens_hsa004500.98286481
40Nitrogen metabolism_Homo sapiens_hsa009100.98101231
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97384814
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90153567
43Basal cell carcinoma_Homo sapiens_hsa052170.88113250
44Arachidonic acid metabolism_Homo sapiens_hsa005900.84800713
45Fat digestion and absorption_Homo sapiens_hsa049750.84688376
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84587257
47Nucleotide excision repair_Homo sapiens_hsa034200.83226305
48RNA transport_Homo sapiens_hsa030130.81360348
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80307209
50Morphine addiction_Homo sapiens_hsa050320.78891642
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77920828
52Purine metabolism_Homo sapiens_hsa002300.77330227
53Sulfur metabolism_Homo sapiens_hsa009200.77146109
54Pyrimidine metabolism_Homo sapiens_hsa002400.73322266
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.72472798
56Chemical carcinogenesis_Homo sapiens_hsa052040.71664128
57Hedgehog signaling pathway_Homo sapiens_hsa043400.70813561
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70514710
59GABAergic synapse_Homo sapiens_hsa047270.69436267
60Fatty acid elongation_Homo sapiens_hsa000620.68336704
61Fatty acid degradation_Homo sapiens_hsa000710.68295646
62Insulin secretion_Homo sapiens_hsa049110.67816131
63Metabolic pathways_Homo sapiens_hsa011000.67684060
64Collecting duct acid secretion_Homo sapiens_hsa049660.66894825
65Basal transcription factors_Homo sapiens_hsa030220.66581087
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66423588
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66153078
68Ether lipid metabolism_Homo sapiens_hsa005650.65295330
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.62963904
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.60871365
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56734683
72Fatty acid biosynthesis_Homo sapiens_hsa000610.55244216
73Thyroid hormone synthesis_Homo sapiens_hsa049180.54036143
74Glutamatergic synapse_Homo sapiens_hsa047240.53110228
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52773538
76Caffeine metabolism_Homo sapiens_hsa002320.52039390
77Non-homologous end-joining_Homo sapiens_hsa034500.51366027
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50364103
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47672896
80Systemic lupus erythematosus_Homo sapiens_hsa053220.47559865
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46004732
82Fatty acid metabolism_Homo sapiens_hsa012120.45618745
83Rheumatoid arthritis_Homo sapiens_hsa053230.44962310
84Spliceosome_Homo sapiens_hsa030400.42281870
85Tyrosine metabolism_Homo sapiens_hsa003500.41814660
86Regulation of autophagy_Homo sapiens_hsa041400.40087193
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40082184
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.39321574
89Fanconi anemia pathway_Homo sapiens_hsa034600.37763858
90Retinol metabolism_Homo sapiens_hsa008300.36942111
91Glutathione metabolism_Homo sapiens_hsa004800.36791323
92Arginine and proline metabolism_Homo sapiens_hsa003300.36516866
93Serotonergic synapse_Homo sapiens_hsa047260.34628822
94Circadian entrainment_Homo sapiens_hsa047130.34010393
95Synaptic vesicle cycle_Homo sapiens_hsa047210.33735567
96Antigen processing and presentation_Homo sapiens_hsa046120.31576466
97Salivary secretion_Homo sapiens_hsa049700.30666921
98Steroid biosynthesis_Homo sapiens_hsa001000.30301670
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27534562
100Pancreatic secretion_Homo sapiens_hsa049720.26946744

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