RPL17P33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.87166829
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.19516373
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.86913667
4ATP synthesis coupled proton transport (GO:0015986)5.86913667
5viral transcription (GO:0019083)5.68059632
6translational termination (GO:0006415)5.45733852
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.37579737
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.14062650
9cotranslational protein targeting to membrane (GO:0006613)5.05832264
10protein targeting to ER (GO:0045047)5.05048849
11respiratory electron transport chain (GO:0022904)4.96883492
12electron transport chain (GO:0022900)4.88345029
13protein localization to endoplasmic reticulum (GO:0070972)4.82442162
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.82251877
15translational elongation (GO:0006414)4.70695289
16DNA deamination (GO:0045006)4.53625650
17maturation of SSU-rRNA (GO:0030490)4.42605246
18protein neddylation (GO:0045116)4.41709224
19ribosomal large subunit biogenesis (GO:0042273)4.28326512
20response to pheromone (GO:0019236)4.05416191
21protein complex biogenesis (GO:0070271)4.03117415
22ribosomal small subunit biogenesis (GO:0042274)4.01206261
23cellular protein complex disassembly (GO:0043624)4.00468454
24viral life cycle (GO:0019058)3.97260489
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.86536713
26chaperone-mediated protein transport (GO:0072321)3.85551034
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.81674167
28regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.81284268
29platelet dense granule organization (GO:0060155)3.74507518
30translational initiation (GO:0006413)3.74318549
31cytidine deamination (GO:0009972)3.63102454
32cytidine metabolic process (GO:0046087)3.63102454
33cytidine catabolic process (GO:0006216)3.63102454
34translation (GO:0006412)3.57714133
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56302883
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.56302883
37NADH dehydrogenase complex assembly (GO:0010257)3.56302883
38mitochondrial respiratory chain complex assembly (GO:0033108)3.54090233
39tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.50128616
40RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.50128616
41hydrogen ion transmembrane transport (GO:1902600)3.48238761
42ATP biosynthetic process (GO:0006754)3.40396932
43protein targeting to membrane (GO:0006612)3.30380993
44GPI anchor metabolic process (GO:0006505)3.26830914
45nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.26054958
46positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.25686826
47proton transport (GO:0015992)3.24834266
48GPI anchor biosynthetic process (GO:0006506)3.22657821
49protein complex disassembly (GO:0043241)3.19517407
50hydrogen transport (GO:0006818)3.19162853
51purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.16928354
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15669836
53purine nucleoside triphosphate biosynthetic process (GO:0009145)3.14124805
54behavioral response to nicotine (GO:0035095)3.12154111
55respiratory chain complex IV assembly (GO:0008535)3.10353312
56macromolecular complex disassembly (GO:0032984)3.07473469
57cytochrome complex assembly (GO:0017004)3.06676833
58regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.02463651
59iron-sulfur cluster assembly (GO:0016226)3.01791162
60metallo-sulfur cluster assembly (GO:0031163)3.01791162
61termination of RNA polymerase III transcription (GO:0006386)3.01080393
62transcription elongation from RNA polymerase III promoter (GO:0006385)3.01080393
63regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.00986518
64proteasome assembly (GO:0043248)3.00400332
65mast cell activation (GO:0045576)2.98802556
66water-soluble vitamin biosynthetic process (GO:0042364)2.98718396
67positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.92660090
68pyrimidine ribonucleoside catabolic process (GO:0046133)2.89437487
69axoneme assembly (GO:0035082)2.87176826
70pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.83531561
71nuclear-transcribed mRNA catabolic process (GO:0000956)2.83490146
72regulation of hypersensitivity (GO:0002883)2.82620760
73base-excision repair, AP site formation (GO:0006285)2.81627296
74regulation of cellular amino acid metabolic process (GO:0006521)2.81449183
75sequestering of actin monomers (GO:0042989)2.79217065
76negative regulation of heart rate (GO:0010459)2.78673060
77negative regulation of mast cell activation (GO:0033004)2.72410637
78mast cell degranulation (GO:0043303)2.69530697
79mast cell activation involved in immune response (GO:0002279)2.69530697
80ribonucleoside triphosphate biosynthetic process (GO:0009201)2.68113198
81mRNA catabolic process (GO:0006402)2.62053743
82spliceosomal complex assembly (GO:0000245)2.58763404
83cellular component biogenesis (GO:0044085)2.57609125
84regulation of cellular respiration (GO:0043457)2.56513554
85preassembly of GPI anchor in ER membrane (GO:0016254)2.55299402
86regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.54706750
87one-carbon compound transport (GO:0019755)2.53884895
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.52467439
89negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.49601173
90DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.48509071
91regulation of activation of Janus kinase activity (GO:0010533)2.46805683
92deoxyribose phosphate catabolic process (GO:0046386)2.45829181
93GTP biosynthetic process (GO:0006183)2.42611187
94forebrain morphogenesis (GO:0048853)2.42273190
95signal peptide processing (GO:0006465)2.41364528
96RNA catabolic process (GO:0006401)2.41315622
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.40723673
98mannosylation (GO:0097502)2.40386365
99anterograde synaptic vesicle transport (GO:0048490)2.39798315
100kynurenine metabolic process (GO:0070189)2.39702308

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.61536114
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.53097868
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.15560881
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.00285338
5VDR_22108803_ChIP-Seq_LS180_Human2.84080994
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.82946588
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74995508
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53854228
9EZH2_22144423_ChIP-Seq_EOC_Human2.51509075
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.46406834
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43545962
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33231939
13VDR_23849224_ChIP-Seq_CD4+_Human2.25303093
14ZNF274_21170338_ChIP-Seq_K562_Hela2.17846817
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.11120589
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05576192
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.00727724
18ELK1_19687146_ChIP-ChIP_HELA_Human1.95730836
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91648723
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88624734
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85665791
22IGF1R_20145208_ChIP-Seq_DFB_Human1.85088848
23MYC_18940864_ChIP-ChIP_HL60_Human1.67825956
24TP53_22573176_ChIP-Seq_HFKS_Human1.64814121
25TAF15_26573619_Chip-Seq_HEK293_Human1.63242511
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62943053
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61899712
28EWS_26573619_Chip-Seq_HEK293_Human1.61897450
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.56736576
30FUS_26573619_Chip-Seq_HEK293_Human1.55595428
31FOXP3_21729870_ChIP-Seq_TREG_Human1.54664938
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53553271
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49843601
34FOXA1_25329375_ChIP-Seq_VCAP_Human1.46993491
35FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46993491
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46244092
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46066423
38AR_20517297_ChIP-Seq_VCAP_Human1.41091117
39P300_19829295_ChIP-Seq_ESCs_Human1.40708926
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40392766
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39683080
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.37257822
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.36568423
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35771418
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35646963
46ER_23166858_ChIP-Seq_MCF-7_Human1.35583981
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34039626
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33654557
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31283972
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28448523
51SOX2_19829295_ChIP-Seq_ESCs_Human1.28348777
52NANOG_19829295_ChIP-Seq_ESCs_Human1.28348777
53CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.26108912
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24875768
55NCOR_22424771_ChIP-Seq_293T_Human1.22533792
56GATA3_26560356_Chip-Seq_TH2_Human1.22476406
57AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21676093
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.21139274
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18186318
60CBP_20019798_ChIP-Seq_JUKART_Human1.18186318
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17378592
62PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17156631
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15955701
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.15496268
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15266537
66TAF2_19829295_ChIP-Seq_ESCs_Human1.14313200
67NANOG_20526341_ChIP-Seq_ESCs_Human1.14173070
68PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13449138
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12756719
70ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09849669
71FOXH1_21741376_ChIP-Seq_EPCs_Human1.09172365
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.09163678
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08862817
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07701956
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07465646
76ERG_20517297_ChIP-Seq_VCAP_Human1.06121654
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.04049924
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03961884
79MYC_19829295_ChIP-Seq_ESCs_Human1.03921565
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02936694
81ELK1_22589737_ChIP-Seq_MCF10A_Human1.02837515
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01961806
83IRF1_19129219_ChIP-ChIP_H3396_Human1.00429066
84RBPJ_21746931_ChIP-Seq_IB4_Human1.00046322
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99217778
86STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98550553
87CBX2_27304074_Chip-Seq_ESCs_Mouse0.97651573
88GATA6_21074721_ChIP-Seq_CACO-2_Human0.97107300
89MYB_26560356_Chip-Seq_TH2_Human0.96944410
90HTT_18923047_ChIP-ChIP_STHdh_Human0.96291643
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96271025
92BCAT_22108803_ChIP-Seq_LS180_Human0.95527648
93STAT3_18555785_Chip-Seq_ESCs_Mouse0.94244343
94P53_22387025_ChIP-Seq_ESCs_Mouse0.94054464
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93294605
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93287454
97TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92852864
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91562793
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91403133
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91266613

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.14836786
2MP0005671_abnormal_response_to3.67915323
3MP0001835_abnormal_antigen_presentation3.02507424
4MP0006292_abnormal_olfactory_placode2.96689364
5MP0004147_increased_porphyrin_level2.66405548
6MP0005645_abnormal_hypothalamus_physiol2.48105156
7MP0002837_dystrophic_cardiac_calcinosis2.41804525
8MP0005646_abnormal_pituitary_gland2.24766520
9MP0006072_abnormal_retinal_apoptosis2.22153624
10MP0003646_muscle_fatigue1.96685486
11MP0008877_abnormal_DNA_methylation1.90076915
12MP0002163_abnormal_gland_morphology1.87250074
13MP0009785_altered_susceptibility_to1.86755633
14MP0004142_abnormal_muscle_tone1.82589974
15MP0004145_abnormal_muscle_electrophysio1.76419985
16MP0005551_abnormal_eye_electrophysiolog1.75135200
17MP0008872_abnormal_physiological_respon1.74241643
18MP0000372_irregular_coat_pigmentation1.72255167
19MP0003787_abnormal_imprinting1.71033110
20MP0002876_abnormal_thyroid_physiology1.68243673
21MP0002102_abnormal_ear_morphology1.64245959
22MP0005075_abnormal_melanosome_morpholog1.59689395
23MP0002148_abnormal_hypersensitivity_rea1.57126364
24MP0001800_abnormal_humoral_immune1.54753544
25MP0001905_abnormal_dopamine_level1.53977271
26MP0005379_endocrine/exocrine_gland_phen1.52404161
27MP0003011_delayed_dark_adaptation1.48639489
28MP0005389_reproductive_system_phenotype1.41045271
29MP0003880_abnormal_central_pattern1.40386209
30MP0005253_abnormal_eye_physiology1.38323502
31MP0009333_abnormal_splenocyte_physiolog1.35958693
32MP0008789_abnormal_olfactory_epithelium1.35180027
33MP0003195_calcinosis1.34959212
34MP0005377_hearing/vestibular/ear_phenot1.33711615
35MP0003878_abnormal_ear_physiology1.33711615
36MP0006276_abnormal_autonomic_nervous1.31728347
37MP0002166_altered_tumor_susceptibility1.30438644
38MP0001873_stomach_inflammation1.29496589
39MP0006036_abnormal_mitochondrial_physio1.29264609
40MP0003763_abnormal_thymus_physiology1.27753517
41MP0005084_abnormal_gallbladder_morpholo1.26921564
42MP0000631_abnormal_neuroendocrine_gland1.26320830
43MP0008875_abnormal_xenobiotic_pharmacok1.25586447
44MP0010386_abnormal_urinary_bladder1.25228475
45MP0001968_abnormal_touch/_nociception1.23573564
46MP0002160_abnormal_reproductive_system1.23527421
47MP0005000_abnormal_immune_tolerance1.22777229
48MP0001919_abnormal_reproductive_system1.20507070
49MP0002736_abnormal_nociception_after1.20120308
50MP0001764_abnormal_homeostasis1.16821303
51MP0002006_tumorigenesis1.15675635
52MP0001790_abnormal_immune_system1.15209262
53MP0005387_immune_system_phenotype1.15209262
54MP0003806_abnormal_nucleotide_metabolis1.14261031
55MP0001485_abnormal_pinna_reflex1.13798728
56MP0000685_abnormal_immune_system1.13613100
57MP0002723_abnormal_immune_serum1.12902143
58MP0001529_abnormal_vocalization1.10451900
59MP0008995_early_reproductive_senescence1.07991924
60MP0001819_abnormal_immune_cell1.06854687
61MP0002452_abnormal_antigen_presenting1.06644906
62MP0001986_abnormal_taste_sensitivity1.06299442
63MP0002420_abnormal_adaptive_immunity1.05863767
64MP0000516_abnormal_urinary_system1.04233652
65MP0005367_renal/urinary_system_phenotyp1.04233652
66MP0009764_decreased_sensitivity_to1.02143996
67MP0004885_abnormal_endolymph1.01787623
68MP0003567_abnormal_fetal_cardiomyocyte1.01701553
69MP0001188_hyperpigmentation1.01610065
70MP0002272_abnormal_nervous_system1.00242356
71MP0003186_abnormal_redox_activity0.99558290
72MP0003866_abnormal_defecation0.98107150
73MP0001765_abnormal_ion_homeostasis0.98007648
74MP0009745_abnormal_behavioral_response0.97659094
75MP0005636_abnormal_mineral_homeostasis0.96648674
76MP0002138_abnormal_hepatobiliary_system0.96215623
77MP0002095_abnormal_skin_pigmentation0.96145771
78MP0005025_abnormal_response_to0.94649851
79MP0001486_abnormal_startle_reflex0.94389911
80MP0002638_abnormal_pupillary_reflex0.92011314
81MP0001970_abnormal_pain_threshold0.91628329
82MP0006082_CNS_inflammation0.90387899
83MP0002653_abnormal_ependyma_morphology0.87638353
84MP0001501_abnormal_sleep_pattern0.85264921
85MP0003283_abnormal_digestive_organ0.82314355
86MP0001293_anophthalmia0.82132300
87MP0002277_abnormal_respiratory_mucosa0.81652274
88MP0001984_abnormal_olfaction0.80243489
89MP0005410_abnormal_fertilization0.79301442
90MP0005332_abnormal_amino_acid0.77483352
91MP0002693_abnormal_pancreas_physiology0.76976893
92MP0001440_abnormal_grooming_behavior0.76184809
93MP0003252_abnormal_bile_duct0.76094920
94MP0002234_abnormal_pharynx_morphology0.75933457
95MP0002733_abnormal_thermal_nociception0.75698099
96MP0000716_abnormal_immune_system0.75418129
97MP0002909_abnormal_adrenal_gland0.75044480
98MP0003122_maternal_imprinting0.74812871
99MP0000230_abnormal_systemic_arterial0.74807406
100MP0005085_abnormal_gallbladder_physiolo0.71811924

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.80838655
2Mitochondrial inheritance (HP:0001427)4.53836104
3Abnormal mitochondria in muscle tissue (HP:0008316)4.25720176
4Acute encephalopathy (HP:0006846)4.11707302
5Progressive macrocephaly (HP:0004481)4.09124432
6Absent rod-and cone-mediated responses on ERG (HP:0007688)3.97320923
7Increased CSF lactate (HP:0002490)3.87941973
8Hepatocellular necrosis (HP:0001404)3.84388549
93-Methylglutaconic aciduria (HP:0003535)3.82581717
10Increased hepatocellular lipid droplets (HP:0006565)3.74793023
11Increased intramyocellular lipid droplets (HP:0012240)3.55133977
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.45256200
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.45256200
14Hepatic necrosis (HP:0002605)3.43941786
15Lipid accumulation in hepatocytes (HP:0006561)3.37218221
16Aplastic anemia (HP:0001915)3.30045988
17Renal Fanconi syndrome (HP:0001994)3.29757906
18Congenital stationary night blindness (HP:0007642)3.29134380
19Congenital, generalized hypertrichosis (HP:0004540)3.27288099
20Abnormality of cells of the erythroid lineage (HP:0012130)3.17621070
21Abnormal rod and cone electroretinograms (HP:0008323)3.14823542
22Pancreatic cysts (HP:0001737)3.06492429
23Cerebral edema (HP:0002181)3.05170196
24Reticulocytopenia (HP:0001896)3.03298417
25Macrocytic anemia (HP:0001972)2.94376248
26Molar tooth sign on MRI (HP:0002419)2.93130704
27Abnormality of midbrain morphology (HP:0002418)2.93130704
28Exertional dyspnea (HP:0002875)2.92519102
29Increased muscle lipid content (HP:0009058)2.92146433
30Abolished electroretinogram (ERG) (HP:0000550)2.77671308
31Abnormal number of erythroid precursors (HP:0012131)2.76918921
32IgG deficiency (HP:0004315)2.72742655
33Optic disc pallor (HP:0000543)2.69887543
34Methylmalonic acidemia (HP:0002912)2.55466293
35Constricted visual fields (HP:0001133)2.52021084
36True hermaphroditism (HP:0010459)2.48661301
37Hypoproteinemia (HP:0003075)2.47617382
38Pancreatic fibrosis (HP:0100732)2.45917763
39Abnormal ciliary motility (HP:0012262)2.42623302
40Attenuation of retinal blood vessels (HP:0007843)2.39853309
41Nephronophthisis (HP:0000090)2.39081584
42Decreased central vision (HP:0007663)2.38481959
43Abnormality of renal resorption (HP:0011038)2.36351977
44Lactic acidosis (HP:0003128)2.33152667
45Increased serum lactate (HP:0002151)2.32805328
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.32463044
47Medial flaring of the eyebrow (HP:0010747)2.31689015
48Pallor (HP:0000980)2.31325034
49Stomatitis (HP:0010280)2.27777253
50Abnormality of B cell number (HP:0010975)2.26870864
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.23050977
52Abnormal respiratory epithelium morphology (HP:0012253)2.22426982
53Abnormal respiratory motile cilium morphology (HP:0005938)2.22426982
54Severe combined immunodeficiency (HP:0004430)2.21335232
55Respiratory failure (HP:0002878)2.20313313
56Thyroiditis (HP:0100646)2.18183115
57Abnormal respiratory motile cilium physiology (HP:0012261)2.17457930
58Elevated erythrocyte sedimentation rate (HP:0003565)2.17220758
59Abnormality of the prostate (HP:0008775)2.16488740
60Leukodystrophy (HP:0002415)2.14806813
61Abnormality of the renal cortex (HP:0011035)2.13466749
62Hyperglycinemia (HP:0002154)2.13260563
63Stenosis of the external auditory canal (HP:0000402)2.08026664
64Exercise intolerance (HP:0003546)2.07036306
65Lethargy (HP:0001254)2.06953595
66Abnormality of urine glucose concentration (HP:0011016)2.03800702
67Glycosuria (HP:0003076)2.03800702
68Hyperphosphaturia (HP:0003109)2.02208234
69Absent/shortened dynein arms (HP:0200106)2.01571589
70Dynein arm defect of respiratory motile cilia (HP:0012255)2.01571589
71Abnormality of T cell number (HP:0011839)1.97209971
72Type II lissencephaly (HP:0007260)1.96557910
73Renal cortical cysts (HP:0000803)1.93017693
74Abnormality of macular pigmentation (HP:0008002)1.92348402
75Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90854385
76Oral leukoplakia (HP:0002745)1.90490982
77Abnormality of the renal medulla (HP:0100957)1.89773403
78Respiratory difficulties (HP:0002880)1.89743436
79B lymphocytopenia (HP:0010976)1.89636363
80Pendular nystagmus (HP:0012043)1.89533793
81T lymphocytopenia (HP:0005403)1.89112714
82Chronic sinusitis (HP:0011109)1.88164330
83Methylmalonic aciduria (HP:0012120)1.87617549
84Abnormal hemoglobin (HP:0011902)1.86159098
85Increased IgM level (HP:0003496)1.83765107
86Cerebral palsy (HP:0100021)1.83214920
87Metaphyseal dysplasia (HP:0100255)1.82200858
88Absent thumb (HP:0009777)1.80216057
89Type 2 muscle fiber atrophy (HP:0003554)1.76341341
90Pancytopenia (HP:0001876)1.75341461
91Male pseudohermaphroditism (HP:0000037)1.73045198
92Sclerocornea (HP:0000647)1.72215169
93Hypothermia (HP:0002045)1.71764611
94Generalized aminoaciduria (HP:0002909)1.70147843
95Autoimmune hemolytic anemia (HP:0001890)1.69689396
96Congenital primary aphakia (HP:0007707)1.68514360
97Abnormality of T cells (HP:0002843)1.65598442
98Polydipsia (HP:0001959)1.65219116
99Abnormal drinking behavior (HP:0030082)1.65219116
100Gait imbalance (HP:0002141)1.64825236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK193.79626573
2KDR2.93833255
3TXK2.83657834
4MAP3K122.68535086
5GRK12.63778542
6ADRBK22.44582307
7ZAK2.39601527
8MAP4K22.37496493
9FRK2.35419941
10VRK22.31220597
11TLK12.28114000
12BCKDK1.86094400
13BMPR21.80762090
14BMPR1B1.73708329
15TESK21.65876001
16MYLK1.60656946
17STK161.60406563
18MAP4K11.59514000
19WNK31.58323630
20MUSK1.56242951
21TAOK31.55419665
22KIT1.42509010
23TEC1.41654355
24PINK11.40668021
25WNK41.40188518
26VRK11.35963199
27ITK1.33065044
28NUAK11.32495194
29TNK21.27544883
30ILK1.25183410
31INSRR1.23729351
32OXSR11.14101788
33TRPM71.10540612
34DYRK21.10433575
35DAPK31.04883064
36SYK1.04114037
37BTK1.03158596
38PASK1.01769110
39TIE10.99133104
40DAPK20.99062139
41MAP3K40.97562919
42PIK3CG0.96440385
43FLT30.91834301
44LYN0.90768193
45CSF1R0.90316183
46GRK70.89180558
47SCYL20.88696651
48RPS6KA50.88403374
49OBSCN0.86437361
50FES0.80628786
51GRK60.80555696
52MATK0.80023516
53EIF2AK30.78622217
54DAPK10.77759634
55PRKCQ0.76865312
56MAPK130.75633874
57IKBKB0.74421628
58RPS6KA40.73610916
59TRIM280.73608814
60CAMK10.73179735
61BUB10.71181405
62MST40.69976683
63LCK0.68599021
64CSNK1G10.67628403
65ERBB30.66961947
66LIMK10.64657894
67MKNK10.64269928
68STK390.63511630
69PRKACA0.60979120
70PRKCE0.59414228
71MKNK20.58008814
72CDK30.57642737
73CSNK1G20.56066094
74CSNK1G30.55493222
75MAP2K70.55394336
76CSNK2A20.55007367
77PRKCA0.52163349
78CSNK2A10.51785115
79PIK3CA0.49504516
80PIM10.49255019
81TNIK0.48801818
82MARK30.48563957
83PRKCG0.48556766
84ADRBK10.48162922
85PLK20.45871165
86PIM20.45489073
87MAP3K110.45084060
88PKN10.44596141
89NME10.44437911
90AURKB0.44169194
91CDK80.43680158
92IGF1R0.43028326
93CAMK2A0.42879113
94PRKG10.42245163
95PRKCD0.40245155
96ABL10.39153941
97PHKG10.39072400
98PHKG20.39072400
99ROCK10.38090520
100AURKA0.37234774

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.42276627
2Oxidative phosphorylation_Homo sapiens_hsa001904.19254415
3Asthma_Homo sapiens_hsa053103.94887006
4Parkinsons disease_Homo sapiens_hsa050123.48704383
5Proteasome_Homo sapiens_hsa030503.29240920
6Allograft rejection_Homo sapiens_hsa053303.24099395
7Graft-versus-host disease_Homo sapiens_hsa053323.04536265
8Autoimmune thyroid disease_Homo sapiens_hsa053202.98958040
9Type I diabetes mellitus_Homo sapiens_hsa049402.85289938
10Protein export_Homo sapiens_hsa030602.71533778
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.66909765
12Alzheimers disease_Homo sapiens_hsa050102.38463813
13Primary immunodeficiency_Homo sapiens_hsa053402.36484672
14Huntingtons disease_Homo sapiens_hsa050162.26641879
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.19140317
16Cardiac muscle contraction_Homo sapiens_hsa042602.05508284
17Antigen processing and presentation_Homo sapiens_hsa046122.00185484
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91216810
19RNA polymerase_Homo sapiens_hsa030201.81798410
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61289536
21Rheumatoid arthritis_Homo sapiens_hsa053231.57684559
22Phototransduction_Homo sapiens_hsa047441.46542346
23Homologous recombination_Homo sapiens_hsa034401.44996552
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35681731
25Viral myocarditis_Homo sapiens_hsa054161.33095112
26Hematopoietic cell lineage_Homo sapiens_hsa046401.27926322
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24806399
28Staphylococcus aureus infection_Homo sapiens_hsa051501.18512794
29Linoleic acid metabolism_Homo sapiens_hsa005911.14888914
30RNA degradation_Homo sapiens_hsa030181.09305059
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.08828495
32Systemic lupus erythematosus_Homo sapiens_hsa053221.01731526
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94600114
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86425453
35Olfactory transduction_Homo sapiens_hsa047400.85977157
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81340319
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79745605
38Nitrogen metabolism_Homo sapiens_hsa009100.77832872
39Caffeine metabolism_Homo sapiens_hsa002320.76316270
40One carbon pool by folate_Homo sapiens_hsa006700.74816119
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73802175
42Chemical carcinogenesis_Homo sapiens_hsa052040.72876173
43Basal transcription factors_Homo sapiens_hsa030220.72837994
44Leishmaniasis_Homo sapiens_hsa051400.72497219
45Butanoate metabolism_Homo sapiens_hsa006500.70444088
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69199799
47Peroxisome_Homo sapiens_hsa041460.68126205
48Pyrimidine metabolism_Homo sapiens_hsa002400.67903738
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.67059819
50Propanoate metabolism_Homo sapiens_hsa006400.66476588
51Arachidonic acid metabolism_Homo sapiens_hsa005900.63803754
52Nicotine addiction_Homo sapiens_hsa050330.63407815
53Retinol metabolism_Homo sapiens_hsa008300.62586948
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61958692
55Tryptophan metabolism_Homo sapiens_hsa003800.61594001
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58803936
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58781271
58Fanconi anemia pathway_Homo sapiens_hsa034600.57648661
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56842098
60Purine metabolism_Homo sapiens_hsa002300.55353249
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55230262
62Nucleotide excision repair_Homo sapiens_hsa034200.53721093
63Regulation of autophagy_Homo sapiens_hsa041400.51871099
64Collecting duct acid secretion_Homo sapiens_hsa049660.51080646
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49370304
66Ether lipid metabolism_Homo sapiens_hsa005650.49269795
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.48174419
68Spliceosome_Homo sapiens_hsa030400.47866729
69Metabolic pathways_Homo sapiens_hsa011000.45120821
70Taste transduction_Homo sapiens_hsa047420.44815093
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43208099
72Fat digestion and absorption_Homo sapiens_hsa049750.42721022
73Mismatch repair_Homo sapiens_hsa034300.42264610
74African trypanosomiasis_Homo sapiens_hsa051430.42188398
75Morphine addiction_Homo sapiens_hsa050320.40800668
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.40350688
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35051604
78Sulfur metabolism_Homo sapiens_hsa009200.34874107
79Salivary secretion_Homo sapiens_hsa049700.32768418
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31019799
81GABAergic synapse_Homo sapiens_hsa047270.29839217
82Herpes simplex infection_Homo sapiens_hsa051680.29698886
83beta-Alanine metabolism_Homo sapiens_hsa004100.28476904
84Base excision repair_Homo sapiens_hsa034100.27238545
85Malaria_Homo sapiens_hsa051440.27064432
86RNA transport_Homo sapiens_hsa030130.26342936
87Serotonergic synapse_Homo sapiens_hsa047260.25851758
88T cell receptor signaling pathway_Homo sapiens_hsa046600.25270618
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24418658
90Circadian entrainment_Homo sapiens_hsa047130.20888243
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.20735630
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20501519
93Glutathione metabolism_Homo sapiens_hsa004800.20373560
94Tuberculosis_Homo sapiens_hsa051520.19119838
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18479375
96Selenocompound metabolism_Homo sapiens_hsa004500.18294096
97Tyrosine metabolism_Homo sapiens_hsa003500.17797833
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15212323
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15148708
100DNA replication_Homo sapiens_hsa030300.13305827

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