ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of sarcomere organization (GO:0060297)	8.65656979
2	mitochondrial DNA replication (GO:0006264)	7.88478048
3	eyelid development in camera-type eye (GO:0061029)	7.37469099
4	positive regulation of oligodendrocyte differentiation (GO:0048714)	7.36556092
5	atrial cardiac muscle cell action potential (GO:0086014)	6.94861856
6	negative regulation of JUN kinase activity (GO:0043508)	6.56112889
7	microtubule polymerization or depolymerization (GO:0031109)	6.32276022
8	regulation of MHC class II biosynthetic process (GO:0045346)	6.26699487
9	respiratory tube development (GO:0030323)	5.90494734
10	negative regulation of cardiac muscle tissue growth (GO:0055022)	5.46848879
11	negative regulation of heart growth (GO:0061117)	5.46848879
12	positive regulation of receptor biosynthetic process (GO:0010870)	5.46521581
13	DNA replication checkpoint (GO:0000076)	5.38155758
14	regulation of nuclear cell cycle DNA replication (GO:0033262)	5.30800124
15	translesion synthesis (GO:0019985)	5.29908338
16	negative regulation of mRNA processing (GO:0050686)	5.13242993
17	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	5.05420986
18	mitochondrial DNA metabolic process (GO:0032042)	4.86049241
19	cerebral cortex radially oriented cell migration (GO:0021799)	4.75942312
20	positive regulation of DNA-dependent DNA replication (GO:2000105)	4.67690491
21	seminiferous tubule development (GO:0072520)	4.60948799
22	tRNA methylation (GO:0030488)	4.57239987
23	regulation of DNA endoreduplication (GO:0032875)	4.47160235
24	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	4.34207761
25	glycosphingolipid biosynthetic process (GO:0006688)	4.30593049
26	postreplication repair (GO:0006301)	4.28024531
27	neuron fate determination (GO:0048664)	4.26191367
28	keratinocyte development (GO:0003334)	4.18381357
29	histone H4 deacetylation (GO:0070933)	4.14392826
30	negative regulation of transcription regulatory region DNA binding (GO:2000678)	4.06210036
31	phenylpropanoid metabolic process (GO:0009698)	3.89517534
32	negative regulation of mRNA metabolic process (GO:1903312)	3.87323391
33	histone H3 deacetylation (GO:0070932)	3.80245397
34	regulation of keratinocyte proliferation (GO:0010837)	3.76401064
35	DNA-dependent DNA replication (GO:0006261)	3.75212832
36	ectodermal placode formation (GO:0060788)	3.74070138
37	protein depolymerization (GO:0051261)	3.70345056
38	DNA catabolic process, exonucleolytic (GO:0000738)	3.68330416
39	replication fork processing (GO:0031297)	3.63885432
40	histone deubiquitination (GO:0016578)	3.61891291
41	fatty acid elongation (GO:0030497)	3.60388681
42	snRNA processing (GO:0016180)	3.57860764
43	purine nucleotide salvage (GO:0032261)	3.53854401
44	regulation of oligodendrocyte differentiation (GO:0048713)	3.53179031
45	negative regulation of RNA splicing (GO:0033119)	3.50397275
46	negative regulation of cardiac muscle tissue development (GO:0055026)	3.48934750
47	sialylation (GO:0097503)	3.48787259
48	kynurenine metabolic process (GO:0070189)	3.47699509
49	telomere maintenance via recombination (GO:0000722)	3.46043419
50	spliceosomal tri-snRNP complex assembly (GO:0000244)	3.42189497
51	nucleoside salvage (GO:0043174)	3.41054592
52	tachykinin receptor signaling pathway (GO:0007217)	3.36458510
53	adenosine metabolic process (GO:0046085)	3.29845128
54	mRNA splice site selection (GO:0006376)	3.24083715
55	regulation of heat generation (GO:0031650)	3.23877149
56	cellular response to sterol (GO:0036315)	3.23145498
57	mitotic recombination (GO:0006312)	3.22358587
58	centrosome duplication (GO:0051298)	3.13568454
59	cardiac muscle cell development (GO:0055013)	3.12991534
60	RNA methylation (GO:0001510)	3.10985341
61	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.08311577
62	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.08271283
63	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	3.03613720
64	negative regulation of epidermal cell differentiation (GO:0045605)	3.03229572
65	central nervous system projection neuron axonogenesis (GO:0021952)	3.00468180
66	regulation of transmission of nerve impulse (GO:0051969)	3.00106590
67	regulation of timing of cell differentiation (GO:0048505)	2.99776332
68	protein K48-linked deubiquitination (GO:0071108)	2.99770389
69	snRNA metabolic process (GO:0016073)	2.99644997
70	protein import into peroxisome matrix (GO:0016558)	2.98360194
71	somite development (GO:0061053)	2.96486627
72	positive regulation of glial cell differentiation (GO:0045687)	2.95885327
73	indolalkylamine metabolic process (GO:0006586)	2.93231893
74	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.89192267
75	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.89192267
76	telomere maintenance via semi-conservative replication (GO:0032201)	2.85200684
77	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.85038442
78	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.85038442
79	regulation of receptor biosynthetic process (GO:0010869)	2.84027369
80	termination of RNA polymerase I transcription (GO:0006363)	2.80841311
81	positive regulation of mRNA catabolic process (GO:0061014)	2.80582792
82	trophoblast giant cell differentiation (GO:0060707)	2.79994597
83	phosphatidylethanolamine metabolic process (GO:0046337)	2.78283659
84	cardiac cell development (GO:0055006)	2.77332956
85	transepithelial transport (GO:0070633)	2.76041994
86	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	2.75616538
87	cerebral cortex cell migration (GO:0021795)	2.73249354
88	aspartate family amino acid catabolic process (GO:0009068)	2.71681641
89	histone deacetylation (GO:0016575)	2.70690374
90	otic vesicle formation (GO:0030916)	2.69971610
91	monoubiquitinated protein deubiquitination (GO:0035520)	2.68233574
92	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.67575081
93	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.67385965
94	negative regulation of organ growth (GO:0046621)	2.67006356
95	central nervous system neuron axonogenesis (GO:0021955)	2.66865261
96	dicarboxylic acid catabolic process (GO:0043649)	2.66231424
97	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.64822345
98	positive regulation of neuroblast proliferation (GO:0002052)	2.64691235
99	DNA double-strand break processing (GO:0000729)	11.2200437
100	microtubule depolymerization (GO:0007019)	10.4675988

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RBPJ_22232070_ChIP-Seq_NCS_Mouse	6.83585591
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.58295451
3	E2F7_22180533_ChIP-Seq_HELA_Human	3.70154046
4	SMAD_19615063_ChIP-ChIP_OVARY_Human	3.65035637
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.58146225
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.57873673
7	ZNF274_21170338_ChIP-Seq_K562_Hela	3.30320172
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.10161558
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.85322444
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.70149991
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.65960038
12	VDR_22108803_ChIP-Seq_LS180_Human	2.51948511
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.51124003
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.41533623
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.31720841
16	FUS_26573619_Chip-Seq_HEK293_Human	2.17597754
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.15691433
18	IRF1_19129219_ChIP-ChIP_H3396_Human	2.11579715
19	P300_19829295_ChIP-Seq_ESCs_Human	2.02873693
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.97899257
21	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.91704330
22	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.88820917
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.88745391
24	AR_21572438_ChIP-Seq_LNCaP_Human	1.88086209
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.85692194
26	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.81645495
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.74059979
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.66773587
29	EWS_26573619_Chip-Seq_HEK293_Human	1.66121007
30	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.65906449
31	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.65860621
32	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.65752250
33	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.55975499
34	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.55272447
35	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.53795513
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.45901160
37	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.45697117
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.43707798
39	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.43526270
40	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.42269144
41	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.41202875
42	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.40639828
43	GBX2_23144817_ChIP-Seq_PC3_Human	1.40331314
44	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40084675
45	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.37823759
46	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34207306
47	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.33854973
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.33836585
49	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.33520652
50	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.32135556
51	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.30102005
52	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.29896918
53	EZH2_22144423_ChIP-Seq_EOC_Human	1.29232446
54	ELK1_19687146_ChIP-ChIP_HELA_Human	1.26657846
55	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.26574006
56	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.26151398
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.25583529
58	AR_25329375_ChIP-Seq_VCAP_Human	1.23873995
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.23122126
60	STAT3_23295773_ChIP-Seq_U87_Human	1.21920055
61	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.21754562
62	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.19983579
63	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.15033456
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14462527
65	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.14410869
66	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12981669
67	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.12381058
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.12351716
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12351716
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.11991526
71	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10796499
72	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10101419
73	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09427630
74	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.06971617
75	P53_22387025_ChIP-Seq_ESCs_Mouse	1.06873677
76	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.06371692
77	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04492948
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04492948
79	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03804525
80	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02878559
81	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.02564848
82	P300_18555785_Chip-Seq_ESCs_Mouse	1.01950621
83	KDM2B_26808549_Chip-Seq_REH_Human	0.99971028
84	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.99888987
85	AHR_22903824_ChIP-Seq_MCF-7_Human	0.99106243
86	MYC_18940864_ChIP-ChIP_HL60_Human	0.98972543
87	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.95723371
88	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.95707080
89	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.94277817
90	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.94260297
91	TCF4_23295773_ChIP-Seq_U87_Human	0.93869828
92	TP53_22573176_ChIP-Seq_HFKS_Human	0.93646936
93	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.92413856
94	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.92263492
95	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.91957452
96	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.91628697
97	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.91522704
98	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.89950254
99	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.89831564
100	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.89292281

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002234_abnormal_pharynx_morphology	6.12822285
2	MP0006292_abnormal_olfactory_placode	5.89575762
3	MP0008057_abnormal_DNA_replication	5.05319325
4	MP0003567_abnormal_fetal_cardiomyocyte	4.19982275
5	MP0003806_abnormal_nucleotide_metabolis	3.76140815
6	MP0002163_abnormal_gland_morphology	3.58989045
7	MP0002102_abnormal_ear_morphology	3.08138706
8	MP0004215_abnormal_myocardial_fiber	2.24162669
9	MP0005379_endocrine/exocrine_gland_phen	1.98139238
10	MP0001986_abnormal_taste_sensitivity	1.96221832
11	MP0001299_abnormal_eye_distance/	1.90840059
12	MP0008789_abnormal_olfactory_epithelium	1.87683000
13	MP0001502_abnormal_circadian_rhythm	1.87161133
14	MP0003221_abnormal_cardiomyocyte_apopto	1.85907252
15	MP0003938_abnormal_ear_development	1.80339392
16	MP0002876_abnormal_thyroid_physiology	1.79027160
17	MP0003137_abnormal_impulse_conducting	1.75775610
18	MP0004085_abnormal_heartbeat	1.70283680
19	MP0000631_abnormal_neuroendocrine_gland	1.70207223
20	MP0008877_abnormal_DNA_methylation	1.70002572
21	MP0000778_abnormal_nervous_system	1.64377128
22	MP0002127_abnormal_cardiovascular_syste	1.53610167
23	MP0003755_abnormal_palate_morphology	1.53498185
24	MP0000049_abnormal_middle_ear	1.52204828
25	MP0001346_abnormal_lacrimal_gland	1.49428036
26	MP0008875_abnormal_xenobiotic_pharmacok	1.49088979
27	MP0005551_abnormal_eye_electrophysiolog	1.47856399
28	MP0002751_abnormal_autonomic_nervous	1.47536010
29	MP0000678_abnormal_parathyroid_gland	1.47309801
30	MP0009250_abnormal_appendicular_skeleto	1.38705366
31	MP0003787_abnormal_imprinting	1.28101326
32	MP0002090_abnormal_vision	1.27565193
33	MP0005075_abnormal_melanosome_morpholog	1.23822913
34	MP0000681_abnormal_thyroid_gland	1.22838350
35	MP0009840_abnormal_foam_cell	1.22369285
36	MP0010030_abnormal_orbit_morphology	1.20313226
37	MP0005394_taste/olfaction_phenotype	1.18390317
38	MP0005499_abnormal_olfactory_system	1.18390317
39	MP0000569_abnormal_digit_pigmentation	1.16739037
40	MP0002092_abnormal_eye_morphology	1.15467917
41	MP0001919_abnormal_reproductive_system	1.15401260
42	MP0002938_white_spotting	1.13477499
43	MP0003880_abnormal_central_pattern	1.11410543
44	MP0000920_abnormal_myelination	1.09903918
45	MP0002210_abnormal_sex_determination	1.03942761
46	MP0009703_decreased_birth_body	1.03775121
47	MP0003718_maternal_effect	1.03376945
48	MP0005646_abnormal_pituitary_gland	1.02670357
49	MP0005391_vision/eye_phenotype	0.96253006
50	MP0010094_abnormal_chromosome_stability	0.95068051
51	MP0001485_abnormal_pinna_reflex	0.92578010
52	MP0003121_genomic_imprinting	0.92254634
53	MP0005645_abnormal_hypothalamus_physiol	0.91286896
54	MP0003632_abnormal_nervous_system	0.90258953
55	MP0008058_abnormal_DNA_repair	0.89612885
56	MP0000516_abnormal_urinary_system	0.88038418
57	MP0005367_renal/urinary_system_phenotyp	0.88038418
58	MP0002735_abnormal_chemical_nociception	0.87826929
59	MP0004484_altered_response_of	0.86305106
60	MP0000653_abnormal_sex_gland	0.86009648
61	MP0002184_abnormal_innervation	0.85861844
62	MP0008872_abnormal_physiological_respon	0.85590353
63	MP0001177_atelectasis	0.84837679
64	MP0005266_abnormal_metabolism	0.83320814
65	MP0004883_abnormal_blood_vessel	0.81499215
66	MP0009046_muscle_twitch	0.79654785
67	MP0001324_abnormal_eye_pigmentation	0.79451942
68	MP0004924_abnormal_behavior	0.78774072
69	MP0005386_behavior/neurological_phenoty	0.78774072
70	MP0003638_abnormal_response/metabolism_	0.78492943
71	MP0001145_abnormal_male_reproductive	0.77525079
72	MP0005389_reproductive_system_phenotype	0.76913321
73	MP0002233_abnormal_nose_morphology	0.75971686
74	MP0001119_abnormal_female_reproductive	0.75012165
75	MP0002229_neurodegeneration	0.74883568
76	MP0001929_abnormal_gametogenesis	0.74215579
77	MP0003943_abnormal_hepatobiliary_system	0.73553476
78	MP0000490_abnormal_crypts_of	0.72780412
79	MP0002111_abnormal_tail_morphology	0.67392078
80	MP0003935_abnormal_craniofacial_develop	0.66800965
81	MP0002882_abnormal_neuron_morphology	0.66375993
82	MP0002160_abnormal_reproductive_system	0.66295084
83	MP0005395_other_phenotype	0.65301483
84	MP0004742_abnormal_vestibular_system	0.65232567
85	MP0002272_abnormal_nervous_system	0.64411367
86	MP0003195_calcinosis	0.64034270
87	MP0000647_abnormal_sebaceous_gland	0.63743986
88	MP0000026_abnormal_inner_ear	0.62054139
89	MP0000685_abnormal_immune_system	0.60558296
90	MP0000955_abnormal_spinal_cord	0.59504480
91	MP0000534_abnormal_ureter_morphology	0.59481929
92	MP0002752_abnormal_somatic_nervous	0.58209442
93	MP0004145_abnormal_muscle_electrophysio	0.57877818
94	MP0002168_other_aberrant_phenotype	0.57704284
95	MP0002114_abnormal_axial_skeleton	0.57698772
96	MP0002177_abnormal_outer_ear	0.57260103
97	MP0002116_abnormal_craniofacial_bone	0.57033556
98	MP0005167_abnormal_blood-brain_barrier	0.55187801
99	MP0001879_abnormal_lymphatic_vessel	0.54611186
100	MP0008770_decreased_survivor_rate	0.53841840

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	6.16797195
2	Obstructive sleep apnea (HP:0002870)	6.05837851
3	Slender build (HP:0001533)	5.91810512
4	Spinal cord compression (HP:0002176)	5.67405997
5	Ectopic kidney (HP:0000086)	4.60884314
6	Tented upper lip vermilion (HP:0010804)	4.54899450
7	Exertional dyspnea (HP:0002875)	4.36680792
8	Conjugated hyperbilirubinemia (HP:0002908)	4.29408202
9	Broad alveolar ridges (HP:0000187)	3.78424122
10	Lissencephaly (HP:0001339)	3.46847641
11	Cheilitis (HP:0100825)	3.41784298
12	Sleep apnea (HP:0010535)	3.37422743
13	Renal cortical cysts (HP:0000803)	3.26699244
14	Thyroid-stimulating hormone excess (HP:0002925)	3.10289340
15	Drooling (HP:0002307)	3.10194814
16	Limb hypertonia (HP:0002509)	3.07395611
17	Tachypnea (HP:0002789)	3.03828749
18	Pachygyria (HP:0001302)	3.01884510
19	Neoplasm of the oral cavity (HP:0100649)	3.00246170
20	Hip dysplasia (HP:0001385)	2.98774258
21	Pancreatic fibrosis (HP:0100732)	2.95608157
22	Nephronophthisis (HP:0000090)	2.95443333
23	Excessive salivation (HP:0003781)	2.87637687
24	Volvulus (HP:0002580)	2.83750900
25	Limb-girdle muscle weakness (HP:0003325)	2.83482631
26	Nephrogenic diabetes insipidus (HP:0009806)	2.79204169
27	Metaphyseal dysplasia (HP:0100255)	2.75035162
28	Renal tubular acidosis (HP:0001947)	2.70803547
29	Prolonged partial thromboplastin time (HP:0003645)	2.63632252
30	Intestinal atresia (HP:0011100)	2.57345243
31	Joint hemorrhage (HP:0005261)	2.56809525
32	True hermaphroditism (HP:0010459)	2.53653898
33	Scanning speech (HP:0002168)	2.51959923
34	Progressive microcephaly (HP:0000253)	2.50923815
35	Macular degeneration (HP:0000608)	2.47953602
36	Dyskinesia (HP:0100660)	2.45501695
37	Severe Myopia (HP:0011003)	2.40563993
38	Atonic seizures (HP:0010819)	2.39673686
39	Azoospermia (HP:0000027)	2.38248438
40	Pancreatic cysts (HP:0001737)	2.31982114
41	Convex nasal ridge (HP:0000444)	2.31760811
42	Abnormality of the renal cortex (HP:0011035)	2.26835979
43	Thyroiditis (HP:0100646)	2.25507766
44	Generalized amyotrophy (HP:0003700)	2.19715897
45	Small hand (HP:0200055)	2.19046588
46	Abnormality of the antihelix (HP:0009738)	2.18237547
47	Abnormality of the renal medulla (HP:0100957)	2.17144861
48	Absent frontal sinuses (HP:0002688)	2.16211408
49	Protruding tongue (HP:0010808)	2.16144439
50	Abnormality of the metopic suture (HP:0005556)	2.16074790
51	Abnormality of midbrain morphology (HP:0002418)	2.16052597
52	Molar tooth sign on MRI (HP:0002419)	2.16052597
53	Methylmalonic acidemia (HP:0002912)	2.15559010
54	Delayed myelination (HP:0012448)	2.12904754
55	Hypoplasia of the thymus (HP:0000778)	2.10427856
56	B lymphocytopenia (HP:0010976)	2.09378517
57	Abnormality of B cell number (HP:0010975)	2.07901149
58	Prominent metopic ridge (HP:0005487)	2.07033217
59	Stomatitis (HP:0010280)	2.06932108
60	Osteomalacia (HP:0002749)	2.05828035
61	Palpebral edema (HP:0100540)	2.05510452
62	Sclerocornea (HP:0000647)	2.04845547
63	Abnormality of salivation (HP:0100755)	2.03133691
64	Short 4th metacarpal (HP:0010044)	2.00295826
65	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.00295826
66	Impaired vibration sensation in the lower limbs (HP:0002166)	2.00126737
67	Abnormal spermatogenesis (HP:0008669)	1.99673517
68	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.99663390
69	Primary atrial arrhythmia (HP:0001692)	1.99546589
70	Cone-rod dystrophy (HP:0000548)	1.97060929
71	Abnormality of the intrinsic pathway (HP:0010989)	1.96232126
72	Atrial fibrillation (HP:0005110)	1.95681288
73	Morphological abnormality of the inner ear (HP:0011390)	1.95320843
74	Severe combined immunodeficiency (HP:0004430)	1.95119618
75	Fatigue (HP:0012378)	1.93302484
76	Constricted visual fields (HP:0001133)	1.91433272
77	Poor eye contact (HP:0000817)	1.90813180
78	Hypoplastic iliac wings (HP:0002866)	1.90171207
79	High anterior hairline (HP:0009890)	1.88413681
80	Papilledema (HP:0001085)	1.87272988
81	Anomalous pulmonary venous return (HP:0010772)	1.85087441
82	Gowers sign (HP:0003391)	1.83041123
83	Opisthotonus (HP:0002179)	1.82289885
84	Supraventricular tachycardia (HP:0004755)	1.82044311
85	Myelodysplasia (HP:0002863)	1.80470955
86	Abnormality of the alveolar ridges (HP:0006477)	1.77516775
87	Spastic tetraplegia (HP:0002510)	1.75682182
88	Hypochromic microcytic anemia (HP:0004840)	1.73765900
89	Supraventricular arrhythmia (HP:0005115)	1.73608698
90	Postaxial foot polydactyly (HP:0001830)	1.73534144
91	Abnormality of renal resorption (HP:0011038)	1.73372848
92	Sloping forehead (HP:0000340)	1.72105103
93	Abnormality of the intervertebral disk (HP:0005108)	1.71650588
94	Hypoproteinemia (HP:0003075)	1.70565642
95	Urinary urgency (HP:0000012)	1.69932618
96	Abnormality of cochlea (HP:0000375)	1.67301922
97	Toxemia of pregnancy (HP:0100603)	1.67147451
98	Abnormality of the ileum (HP:0001549)	1.66354151
99	Abnormality of the parathyroid morphology (HP:0011766)	1.66089058
100	Congenital stationary night blindness (HP:0007642)	1.65497492

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.51618844
2	ERBB3	4.49848693
3	STK38L	4.36051828
4	MAPK13	3.96514980
5	EPHA4	3.63257258
6	CASK	2.83937113
7	FRK	2.80474483
8	TNIK	2.63692287
9	MARK1	2.61340084
10	UHMK1	2.47089779
11	TRIM28	2.43203037
12	STK39	2.26558419
13	WNK3	2.01713525
14	EPHA3	1.98588114
15	CDK8	1.85763487
16	NUAK1	1.70879217
17	BRSK2	1.59428178
18	CSNK1G2	1.59026295
19	VRK2	1.57177066
20	BMPR1B	1.52245244
21	STK10	1.50176659
22	BCR	1.46796813
23	STK38	1.44993614
24	OXSR1	1.43628592
25	AKT3	1.40416134
26	TAOK3	1.35633786
27	SIK3	1.34995248
28	DYRK1B	1.29837064
29	ACVR1B	1.17325306
30	MKNK2	1.17155830
31	CAMK4	1.15366738
32	WEE1	1.13864647
33	PNCK	1.09987281
34	CAMKK2	1.07668694
35	DYRK1A	1.01765913
36	CAMK2B	0.97474949
37	TRPM7	0.89130294
38	MARK3	0.86648584
39	NLK	0.86598160
40	PAK3	0.78242782
41	SGK2	0.77145621
42	MST4	0.76217362
43	WNK4	0.69537629
44	MAPK4	0.68707739
45	ATM	0.67436469
46	KIT	0.66921174
47	DYRK3	0.64096989
48	PRKCE	0.63443489
49	PLK2	0.63362948
50	CSNK1A1	0.62305583
51	MKNK1	0.60170405
52	PRKACB	0.60058101
53	MAPKAPK5	0.60008234
54	PIK3CA	0.59855006
55	MAPK8	0.59159859
56	LRRK2	0.59133257
57	FLT3	0.55749197
58	CAMK1G	0.55218806
59	TXK	0.54476818
60	CSNK1E	0.53239257
61	ROCK1	0.52533797
62	EIF2AK3	0.48065609
63	NTRK3	0.47553882
64	CSNK1D	0.47015614
65	SGK3	0.46404556
66	CAMK2D	0.44917514
67	HIPK2	0.43999924
68	SGK223	0.42971204
69	SGK494	0.42971204
70	CSNK1G3	0.42336048
71	GRK5	0.42204940
72	VRK1	0.41941106
73	INSRR	0.41847786
74	PIM1	0.39156407
75	CDK18	0.38852758
76	PIK3CG	0.38450635
77	MAP3K12	0.37494880
78	CDK15	0.37209611
79	PKN1	0.36455011
80	GRK7	0.36407749
81	GRK1	0.35230169
82	CAMK2A	0.33581482
83	EIF2AK2	0.33267661
84	CSNK1A1L	0.33080537
85	CHEK1	0.32997942
86	PRKCQ	0.32883722
87	DYRK2	0.32675464
88	EGFR	0.32409061
89	JAK1	0.32064799
90	CDK14	0.30917241
91	CDK2	0.30382335
92	RPS6KA3	0.30316136
93	MAP3K8	0.30265021
94	CDK11A	0.29646042
95	CSNK1G1	0.29568624
96	SGK1	0.29150175
97	GSK3B	0.28355056
98	LIMK1	0.28348826
99	IGF1R	0.28220662
100	STK4	0.27921310

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fanconi anemia pathway_Homo sapiens_hsa03460	3.86189696
2	Non-homologous end-joining_Homo sapiens_hsa03450	3.62544604
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.03721648
4	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.99931366
5	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.97733338
6	DNA replication_Homo sapiens_hsa03030	2.69828837
7	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.15911904
8	Homologous recombination_Homo sapiens_hsa03440	2.12684452
9	Tryptophan metabolism_Homo sapiens_hsa00380	2.07015349
10	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	2.03385154
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.99827150
12	Circadian rhythm_Homo sapiens_hsa04710	1.99822083
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.93194116
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.87788552
15	RNA degradation_Homo sapiens_hsa03018	1.84475187
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.80274412
17	Caffeine metabolism_Homo sapiens_hsa00232	1.78069757
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.76850924
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.75957350
20	RNA polymerase_Homo sapiens_hsa03020	1.73123787
21	Phototransduction_Homo sapiens_hsa04744	1.72094326
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.71645436
23	Fatty acid elongation_Homo sapiens_hsa00062	1.70053907
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.52243716
25	Fat digestion and absorption_Homo sapiens_hsa04975	1.50456100
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.46592299
27	Lysine degradation_Homo sapiens_hsa00310	1.46292799
28	Histidine metabolism_Homo sapiens_hsa00340	1.44920339
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.44365122
30	Spliceosome_Homo sapiens_hsa03040	1.36862510
31	Fatty acid degradation_Homo sapiens_hsa00071	1.35785881
32	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.32186595
33	Notch signaling pathway_Homo sapiens_hsa04330	1.29687170
34	Basal transcription factors_Homo sapiens_hsa03022	1.25608974
35	Glycerolipid metabolism_Homo sapiens_hsa00561	1.25574662
36	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.22138333
37	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.19998552
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.17489357
39	Propanoate metabolism_Homo sapiens_hsa00640	1.16115478
40	Cell cycle_Homo sapiens_hsa04110	1.13693010
41	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.13254850
42	Butanoate metabolism_Homo sapiens_hsa00650	1.12110242
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.11333492
44	Chemical carcinogenesis_Homo sapiens_hsa05204	1.09961270
45	Peroxisome_Homo sapiens_hsa04146	1.06360154
46	mRNA surveillance pathway_Homo sapiens_hsa03015	1.05711422
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.02948477
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.01788312
49	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.01095151
50	Mismatch repair_Homo sapiens_hsa03430	0.94427545
51	Protein export_Homo sapiens_hsa03060	0.92446329
52	Salivary secretion_Homo sapiens_hsa04970	0.89482488
53	Pyruvate metabolism_Homo sapiens_hsa00620	0.82226407
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.79074379
55	Renin secretion_Homo sapiens_hsa04924	0.77746095
56	Sphingolipid metabolism_Homo sapiens_hsa00600	0.77305374
57	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.76108138
58	Retinol metabolism_Homo sapiens_hsa00830	0.75342151
59	Type I diabetes mellitus_Homo sapiens_hsa04940	0.72203398
60	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.70499697
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.66756220
62	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.66408238
63	Regulation of autophagy_Homo sapiens_hsa04140	0.66404157
64	Proteasome_Homo sapiens_hsa03050	0.65654162
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.63734599
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63515403
67	Basal cell carcinoma_Homo sapiens_hsa05217	0.61048612
68	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.60794900
69	Olfactory transduction_Homo sapiens_hsa04740	0.60545287
70	Purine metabolism_Homo sapiens_hsa00230	0.58508560
71	Oocyte meiosis_Homo sapiens_hsa04114	0.55609331
72	Nitrogen metabolism_Homo sapiens_hsa00910	0.53054267
73	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.52570610
74	Pyrimidine metabolism_Homo sapiens_hsa00240	0.50592161
75	Circadian entrainment_Homo sapiens_hsa04713	0.48589088
76	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.48537093
77	MicroRNAs in cancer_Homo sapiens_hsa05206	0.48178583
78	Complement and coagulation cascades_Homo sapiens_hsa04610	0.47872471
79	Allograft rejection_Homo sapiens_hsa05330	0.45659031
80	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.42890146
81	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.42304662
82	Axon guidance_Homo sapiens_hsa04360	0.42015319
83	Morphine addiction_Homo sapiens_hsa05032	0.42012915
84	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.39692375
85	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.39476966
86	ABC transporters_Homo sapiens_hsa02010	0.38955328
87	p53 signaling pathway_Homo sapiens_hsa04115	0.37228334
88	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.37099467
89	African trypanosomiasis_Homo sapiens_hsa05143	0.36581617
90	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.33083778
91	GABAergic synapse_Homo sapiens_hsa04727	0.31888794
92	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.30502210
93	Serotonergic synapse_Homo sapiens_hsa04726	0.30015475
94	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.28944099
95	Glutamatergic synapse_Homo sapiens_hsa04724	0.27361086
96	Metabolic pathways_Homo sapiens_hsa01100	0.26283696
97	Wnt signaling pathway_Homo sapiens_hsa04310	0.25235897
98	Measles_Homo sapiens_hsa05162	0.24982802
99	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.24614935
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.24181545

RPL17P40

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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