ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.26338253
2	maturation of SSU-rRNA (GO:0030490)	8.05693322
3	translational termination (GO:0006415)	7.87137911
4	ribosomal small subunit biogenesis (GO:0042274)	7.71862689
5	ribosomal small subunit assembly (GO:0000028)	7.45541875
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.62697307
7	translational elongation (GO:0006414)	6.57340385
8	cotranslational protein targeting to membrane (GO:0006613)	6.55075524
9	protein targeting to ER (GO:0045047)	6.53223477
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.22749037
11	protein localization to endoplasmic reticulum (GO:0070972)	6.15001465
12	ATP synthesis coupled proton transport (GO:0015986)	6.14528374
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.14528374
14	viral life cycle (GO:0019058)	6.00225712
15	cellular protein complex disassembly (GO:0043624)	5.93303538
16	protein neddylation (GO:0045116)	5.85507053
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.78333948
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.77521207
19	chaperone-mediated protein transport (GO:0072321)	5.70673237
20	translational initiation (GO:0006413)	5.06962260
21	protein complex disassembly (GO:0043241)	4.99376975
22	macromolecular complex disassembly (GO:0032984)	4.72995029
23	behavioral response to nicotine (GO:0035095)	4.53391755
24	protein targeting to membrane (GO:0006612)	4.49093148
25	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.27092784
26	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.18755399
27	NADH dehydrogenase complex assembly (GO:0010257)	4.14627125
28	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.14627125
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.14627125
30	ribosomal large subunit biogenesis (GO:0042273)	4.09981324
31	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.99935582
32	pattern specification involved in kidney development (GO:0061004)	3.97742480
33	protein complex biogenesis (GO:0070271)	3.94774504
34	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.93776213
35	translation (GO:0006412)	3.93652687
36	tongue development (GO:0043586)	3.87203521
37	mRNA catabolic process (GO:0006402)	3.84709946
38	respiratory electron transport chain (GO:0022904)	3.82814983
39	electron transport chain (GO:0022900)	3.81148310
40	nonmotile primary cilium assembly (GO:0035058)	3.73882107
41	ATP biosynthetic process (GO:0006754)	3.73862297
42	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.59408125
43	mitochondrial respiratory chain complex assembly (GO:0033108)	3.52064315
44	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.52049834
45	water-soluble vitamin biosynthetic process (GO:0042364)	3.50970634
46	cell proliferation in forebrain (GO:0021846)	3.50895926
47	cellular component biogenesis (GO:0044085)	3.46848365
48	somite development (GO:0061053)	3.44300825
49	RNA catabolic process (GO:0006401)	3.40035881
50	axonemal dynein complex assembly (GO:0070286)	3.38608534
51	neuron fate determination (GO:0048664)	3.36259861
52	ribonucleoprotein complex biogenesis (GO:0022613)	3.32328352
53	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.22806364
54	substrate-independent telencephalic tangential migration (GO:0021826)	3.18518357
55	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.18518357
56	hydrogen ion transmembrane transport (GO:1902600)	3.14139419
57	GTP biosynthetic process (GO:0006183)	3.13636580
58	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.12602481
59	response to redox state (GO:0051775)	3.11225948
60	establishment of protein localization to membrane (GO:0090150)	3.03403558
61	epithelial cilium movement (GO:0003351)	3.03378118
62	regulation of cilium movement (GO:0003352)	3.02480036
63	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.97067991
64	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.97067991
65	protein polyglutamylation (GO:0018095)	2.92129063
66	synaptic transmission, cholinergic (GO:0007271)	2.90545323
67	central nervous system myelination (GO:0022010)	2.90199051
68	axon ensheathment in central nervous system (GO:0032291)	2.90199051
69	proton transport (GO:0015992)	2.88943505
70	protein targeting (GO:0006605)	2.88350695
71	segment specification (GO:0007379)	2.88008392
72	hydrogen transport (GO:0006818)	2.82699653
73	pyrimidine nucleotide catabolic process (GO:0006244)	2.75848128
74	auditory receptor cell differentiation (GO:0042491)	2.72489280
75	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.66348738
76	UTP biosynthetic process (GO:0006228)	2.64702979
77	regulation of microtubule-based movement (GO:0060632)	2.61213897
78	head development (GO:0060322)	2.61003280
79	ncRNA 3-end processing (GO:0043628)	2.60191658
80	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.59058177
81	otic vesicle formation (GO:0030916)	2.57045731
82	establishment of protein localization to organelle (GO:0072594)	2.56680314
83	intracellular protein transmembrane import (GO:0044743)	2.56355206
84	nucleoside triphosphate biosynthetic process (GO:0009142)	2.55017110
85	nephron tubule morphogenesis (GO:0072078)	2.51260668
86	nephron epithelium morphogenesis (GO:0072088)	2.51260668
87	cilium movement (GO:0003341)	2.50632064
88	positive regulation of respiratory burst (GO:0060267)	2.48847930
89	limb development (GO:0060173)	2.48659613
90	appendage development (GO:0048736)	2.48659613
91	hypothalamus development (GO:0021854)	2.46473640
92	rRNA processing (GO:0006364)	2.45048492
93	cellular ketone body metabolic process (GO:0046950)	2.43083227
94	rRNA metabolic process (GO:0016072)	2.42010423
95	parturition (GO:0007567)	2.41515830
96	telencephalon development (GO:0021537)	2.41413910
97	protein localization to membrane (GO:0072657)	2.40400018
98	UTP metabolic process (GO:0046051)	2.40284433
99	DNA deamination (GO:0045006)	2.38170850
100	protein peptidyl-prolyl isomerization (GO:0000413)	2.37098282

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.26938027
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.11807968
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.93122308
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.61141634
5	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.36374463
6	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.29735242
7	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.28511532
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.24736897
9	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.17078094
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.11562132
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.10945465
12	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.09922627
13	VDR_22108803_ChIP-Seq_LS180_Human	2.09205055
14	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.03467599
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.00058900
16	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.92816367
17	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.91977619
18	IRF1_19129219_ChIP-ChIP_H3396_Human	1.88794731
19	MYC_18940864_ChIP-ChIP_HL60_Human	1.70928501
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.70053884
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.68932249
22	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.68538509
23	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.65345211
24	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.64132265
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.62512438
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61129389
27	REST_21632747_ChIP-Seq_MESCs_Mouse	1.58324955
28	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.57832745
29	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.56499715
30	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.54859884
31	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.52400778
32	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.52400778
33	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.51132746
34	TTF2_22483619_ChIP-Seq_HELA_Human	1.47803597
35	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.45139117
36	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.42814343
37	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.42346261
38	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.40032894
39	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.39748783
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.38757073
41	EWS_26573619_Chip-Seq_HEK293_Human	1.38498431
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.37039662
43	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.36195855
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.36069107
45	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.34077329
46	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.32490268
47	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.30699390
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28001142
49	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.27577570
50	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.26564944
51	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.26191397
52	FUS_26573619_Chip-Seq_HEK293_Human	1.25770859
53	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.24485144
54	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.24367038
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.24149215
56	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.21399824
57	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.21303673
58	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.20970610
59	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.20465040
60	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.19977768
61	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.17114079
62	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.16248119
63	ELK1_19687146_ChIP-ChIP_HELA_Human	1.16039793
64	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.13033284
65	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11295243
66	P300_19829295_ChIP-Seq_ESCs_Human	1.10401336
67	XRN2_22483619_ChIP-Seq_HELA_Human	1.09453879
68	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.09378506
69	ERA_21632823_ChIP-Seq_H3396_Human	1.09231792
70	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.08736186
71	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08350950
72	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.06762436
73	TAF2_19829295_ChIP-Seq_ESCs_Human	1.05422377
74	NANOG_20526341_ChIP-Seq_ESCs_Human	1.04571323
75	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.04392586
76	NCOR_22424771_ChIP-Seq_293T_Human	1.04090507
77	VDR_23849224_ChIP-Seq_CD4+_Human	1.01251258
78	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.00787466
79	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.97799749
80	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.96642563
81	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.95466616
82	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95466616
83	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.94839360
84	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.92291517
85	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.91768411
86	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.91382881
87	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.90868733
88	NANOG_19829295_ChIP-Seq_ESCs_Human	0.90097170
89	SOX2_19829295_ChIP-Seq_ESCs_Human	0.90097170
90	CTCF_27219007_Chip-Seq_Bcells_Human	0.89423847
91	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.88618167
92	GABP_19822575_ChIP-Seq_HepG2_Human	0.88420308
93	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.88165878
94	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.87423108
95	MYC_19829295_ChIP-Seq_ESCs_Human	0.86692105
96	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.86678837
97	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.85655295
98	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.85548540
99	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.85136871
100	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.85136871

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.71239531
2	MP0006292_abnormal_olfactory_placode	4.11905577
3	MP0003136_yellow_coat_color	3.09769783
4	MP0003787_abnormal_imprinting	3.01897238
5	MP0003122_maternal_imprinting	2.88309782
6	MP0004142_abnormal_muscle_tone	2.48523458
7	MP0002163_abnormal_gland_morphology	2.28114643
8	MP0003121_genomic_imprinting	2.25943605
9	MP0003123_paternal_imprinting	2.22539376
10	MP0008789_abnormal_olfactory_epithelium	2.13635965
11	MP0001485_abnormal_pinna_reflex	2.07097251
12	MP0008877_abnormal_DNA_methylation	2.06908021
13	MP0000566_synostosis	2.05253500
14	MP0003283_abnormal_digestive_organ	1.97424776
15	MP0001293_anophthalmia	1.95349723
16	MP0000049_abnormal_middle_ear	1.91733961
17	MP0002653_abnormal_ependyma_morphology	1.87901187
18	MP0003646_muscle_fatigue	1.75792498
19	MP0004885_abnormal_endolymph	1.75031987
20	MP0006276_abnormal_autonomic_nervous	1.69601701
21	MP0000778_abnormal_nervous_system	1.64408908
22	MP0005499_abnormal_olfactory_system	1.56093084
23	MP0005394_taste/olfaction_phenotype	1.56093084
24	MP0001968_abnormal_touch/_nociception	1.50642758
25	MP0005084_abnormal_gallbladder_morpholo	1.49084786
26	MP0005379_endocrine/exocrine_gland_phen	1.47087901
27	MP0005377_hearing/vestibular/ear_phenot	1.45767407
28	MP0003878_abnormal_ear_physiology	1.45767407
29	MP0002234_abnormal_pharynx_morphology	1.44308777
30	MP0002638_abnormal_pupillary_reflex	1.43578821
31	MP0000631_abnormal_neuroendocrine_gland	1.41377547
32	MP0006072_abnormal_retinal_apoptosis	1.41116695
33	MP0002938_white_spotting	1.40669356
34	MP0004145_abnormal_muscle_electrophysio	1.38786864
35	MP0003879_abnormal_hair_cell	1.37708332
36	MP0005551_abnormal_eye_electrophysiolog	1.36249766
37	MP0010030_abnormal_orbit_morphology	1.34823445
38	MP0002837_dystrophic_cardiac_calcinosis	1.34191635
39	MP0001986_abnormal_taste_sensitivity	1.33899346
40	MP0001529_abnormal_vocalization	1.33306480
41	MP0002184_abnormal_innervation	1.30984269
42	MP0002736_abnormal_nociception_after	1.27915493
43	MP0002095_abnormal_skin_pigmentation	1.27213944
44	MP0002272_abnormal_nervous_system	1.26185134
45	MP0003011_delayed_dark_adaptation	1.26112340
46	MP0002160_abnormal_reproductive_system	1.25744692
47	MP0005646_abnormal_pituitary_gland	1.24598099
48	MP0002876_abnormal_thyroid_physiology	1.24433036
49	MP0002557_abnormal_social/conspecific_i	1.20600572
50	MP0000026_abnormal_inner_ear	1.19360739
51	MP0008872_abnormal_physiological_respon	1.18925357
52	MP0001188_hyperpigmentation	1.17497204
53	MP0002102_abnormal_ear_morphology	1.16324700
54	MP0005195_abnormal_posterior_eye	1.13281393
55	MP0004133_heterotaxia	1.12739308
56	MP0001905_abnormal_dopamine_level	1.12634236
57	MP0003186_abnormal_redox_activity	1.11684680
58	MP0005389_reproductive_system_phenotype	1.11329625
59	MP0003119_abnormal_digestive_system	1.07705172
60	MP0002752_abnormal_somatic_nervous	1.07674950
61	MP0009745_abnormal_behavioral_response	1.07375411
62	MP0004742_abnormal_vestibular_system	1.07198384
63	MP0000955_abnormal_spinal_cord	1.06306333
64	MP0002233_abnormal_nose_morphology	1.06168119
65	MP0008875_abnormal_xenobiotic_pharmacok	1.05947941
66	MP0001440_abnormal_grooming_behavior	1.04762303
67	MP0002572_abnormal_emotion/affect_behav	1.03949684
68	MP0003880_abnormal_central_pattern	1.03762039
69	MP0003315_abnormal_perineum_morphology	1.03107397
70	MP0000427_abnormal_hair_cycle	1.02263329
71	MP0003938_abnormal_ear_development	1.00767262
72	MP0001963_abnormal_hearing_physiology	0.99546133
73	MP0002063_abnormal_learning/memory/cond	0.97896163
74	MP0002277_abnormal_respiratory_mucosa	0.97758075
75	MP0009046_muscle_twitch	0.96249085
76	MP0001970_abnormal_pain_threshold	0.94245898
77	MP0000613_abnormal_salivary_gland	0.94171647
78	MP0003635_abnormal_synaptic_transmissio	0.91907015
79	MP0003937_abnormal_limbs/digits/tail_de	0.90650700
80	MP0005645_abnormal_hypothalamus_physiol	0.90132494
81	MP0003755_abnormal_palate_morphology	0.87254302
82	MP0002067_abnormal_sensory_capabilities	0.86432035
83	MP0003942_abnormal_urinary_system	0.86224716
84	MP0001919_abnormal_reproductive_system	0.86171406
85	MP0002928_abnormal_bile_duct	0.85963367
86	MP0001486_abnormal_startle_reflex	0.85322042
87	MP0002733_abnormal_thermal_nociception	0.84387159
88	MP0005253_abnormal_eye_physiology	0.83942406
89	MP0005174_abnormal_tail_pigmentation	0.83816318
90	MP0001286_abnormal_eye_development	0.83804051
91	MP0003890_abnormal_embryonic-extraembry	0.83596998
92	MP0003567_abnormal_fetal_cardiomyocyte	0.80755223
93	MP0003195_calcinosis	0.80573655
94	MP0002249_abnormal_larynx_morphology	0.80131218
95	MP0003183_abnormal_peptide_metabolism	0.77057763
96	MP0001348_abnormal_lacrimal_gland	0.76988907
97	MP0002064_seizures	0.74617665
98	MP0002882_abnormal_neuron_morphology	0.73214493
99	MP0002734_abnormal_mechanical_nocicepti	0.71736419
100	MP0004043_abnormal_pH_regulation	0.70547023

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.77830213
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.81002583
3	Macrocytic anemia (HP:0001972)	4.01034336
4	Stenosis of the external auditory canal (HP:0000402)	3.85595061
5	Acute necrotizing encephalopathy (HP:0006965)	3.84852971
6	Septo-optic dysplasia (HP:0100842)	3.78251603
7	Molar tooth sign on MRI (HP:0002419)	3.67730280
8	Abnormality of midbrain morphology (HP:0002418)	3.67730280
9	Abnormal number of erythroid precursors (HP:0012131)	3.47021136
10	Acute encephalopathy (HP:0006846)	3.39495998
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.32334460
12	Mitochondrial inheritance (HP:0001427)	3.15771679
13	Progressive macrocephaly (HP:0004481)	3.10488045
14	Rib fusion (HP:0000902)	3.09762015
15	Pancreatic fibrosis (HP:0100732)	3.05019843
16	Pallor (HP:0000980)	3.04962190
17	Pancreatic cysts (HP:0001737)	3.04101953
18	Increased CSF lactate (HP:0002490)	2.87558066
19	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.74655646
20	Partial duplication of thumb phalanx (HP:0009944)	2.73435182
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.69342611
22	True hermaphroditism (HP:0010459)	2.67031559
23	Lipid accumulation in hepatocytes (HP:0006561)	2.66466089
24	Abnormality of the labia minora (HP:0012880)	2.60545515
25	Increased hepatocellular lipid droplets (HP:0006565)	2.54753054
26	Nephronophthisis (HP:0000090)	2.51296220
27	Medial flaring of the eyebrow (HP:0010747)	2.50986645
28	Hyperglycinemia (HP:0002154)	2.50705318
29	Anophthalmia (HP:0000528)	2.49682120
30	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.44044964
31	Absent septum pellucidum (HP:0001331)	2.42899330
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.42145637
33	Absent thumb (HP:0009777)	2.39753723
34	Asplenia (HP:0001746)	2.35600556
35	Maternal diabetes (HP:0009800)	2.35108664
36	Congenital stationary night blindness (HP:0007642)	2.33755037
37	Abnormal respiratory motile cilium morphology (HP:0005938)	2.33431792
38	Abnormal respiratory epithelium morphology (HP:0012253)	2.33431792
39	Hypoplasia of the radius (HP:0002984)	2.31932528
40	Partial duplication of the phalanx of hand (HP:0009999)	2.31433511
41	Hepatocellular necrosis (HP:0001404)	2.25885857
42	Gait imbalance (HP:0002141)	2.24261255
43	Abnormality of the diencephalon (HP:0010662)	2.23854568
44	Oligodactyly (hands) (HP:0001180)	2.23250603
45	Pendular nystagmus (HP:0012043)	2.22590613
46	Type 2 muscle fiber atrophy (HP:0003554)	2.22186185
47	Abnormal hemoglobin (HP:0011902)	2.21937754
48	Renal Fanconi syndrome (HP:0001994)	2.20782156
49	Cerebral edema (HP:0002181)	2.17101168
50	Hypoplasia of the ulna (HP:0003022)	2.13852401
51	3-Methylglutaconic aciduria (HP:0003535)	2.12819541
52	Absent/shortened dynein arms (HP:0200106)	2.11900387
53	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.11900387
54	Type II lissencephaly (HP:0007260)	2.11011375
55	Agitation (HP:0000713)	2.10311688
56	Depressed nasal ridge (HP:0000457)	2.08581465
57	Optic disc pallor (HP:0000543)	2.07822431
58	Sclerocornea (HP:0000647)	2.07438873
59	Cystic liver disease (HP:0006706)	2.06248593
60	Congenital primary aphakia (HP:0007707)	2.04900847
61	Abnormal ciliary motility (HP:0012262)	2.03990934
62	Anencephaly (HP:0002323)	2.02389964
63	Supernumerary spleens (HP:0009799)	2.01103604
64	Hepatic necrosis (HP:0002605)	1.97926005
65	Vaginal atresia (HP:0000148)	1.97826308
66	Abnormal respiratory motile cilium physiology (HP:0012261)	1.97758445
67	11 pairs of ribs (HP:0000878)	1.97399783
68	Esophageal atresia (HP:0002032)	1.97001964
69	Congenital, generalized hypertrichosis (HP:0004540)	1.95318562
70	Abnormality of DNA repair (HP:0003254)	1.94755215
71	Abnormality of the renal medulla (HP:0100957)	1.93095068
72	Optic nerve hypoplasia (HP:0000609)	1.92320713
73	Abolished electroretinogram (ERG) (HP:0000550)	1.91673798
74	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.90524636
75	Genital tract atresia (HP:0001827)	1.89731519
76	Forearm undergrowth (HP:0009821)	1.89028118
77	Abnormality of renal resorption (HP:0011038)	1.88873521
78	Muscle fiber atrophy (HP:0100295)	1.88343562
79	Polyphagia (HP:0002591)	1.88026812
80	Increased intramyocellular lipid droplets (HP:0012240)	1.85724914
81	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.82585786
82	B lymphocytopenia (HP:0010976)	1.81740020
83	Nephrogenic diabetes insipidus (HP:0009806)	1.81609750
84	Missing ribs (HP:0000921)	1.81462248
85	Oligodactyly (HP:0012165)	1.81339797
86	Methylmalonic acidemia (HP:0002912)	1.80711512
87	Postaxial foot polydactyly (HP:0001830)	1.79087147
88	Triphalangeal thumb (HP:0001199)	1.78436792
89	Chronic hepatic failure (HP:0100626)	1.76625077
90	Poor suck (HP:0002033)	1.73160506
91	Abnormality of the septum pellucidum (HP:0007375)	1.73046279
92	Growth hormone deficiency (HP:0000824)	1.72176249
93	Myokymia (HP:0002411)	1.70413949
94	Postaxial hand polydactyly (HP:0001162)	1.70166299
95	Increased serum lactate (HP:0002151)	1.69960163
96	Male pseudohermaphroditism (HP:0000037)	1.69593321
97	Adrenal hypoplasia (HP:0000835)	1.68692379
98	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.67903346
99	Abnormality of the middle phalanges of the toes (HP:0010183)	1.67626467
100	Hyperthyroidism (HP:0000836)	1.66914168

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.39667320
2	CDK19	2.83878297
3	CASK	2.56991058
4	GRK1	2.55170787
5	ADRBK2	2.52860124
6	STK16	2.50479774
7	DYRK2	2.49642673
8	PINK1	2.47509538
9	BMPR1B	2.18685142
10	NUAK1	2.18465023
11	TXK	2.14243838
12	EPHB2	1.98718156
13	TIE1	1.91952469
14	STK39	1.84694138
15	TLK1	1.77917681
16	MUSK	1.67927554
17	MAP3K4	1.60117257
18	VRK2	1.59048485
19	ZAK	1.57993805
20	WNK3	1.57600748
21	PIK3CA	1.52604476
22	FRK	1.50547253
23	LRRK2	1.50544625
24	WNK1	1.47850131
25	MAP3K12	1.46472860
26	NTRK2	1.39290842
27	PRKCG	1.35226576
28	MAP2K7	1.33561893
29	OXSR1	1.28230960
30	INSRR	1.20310122
31	CDC7	1.15412503
32	MARK1	1.14948432
33	NME1	1.14243433
34	NEK1	1.11239239
35	DMPK	1.09461902
36	CAMK1	1.06942144
37	MAP3K11	1.06348069
38	PNCK	1.06115734
39	BCKDK	1.04044740
40	STK11	1.01922976
41	FGFR2	0.98162345
42	VRK1	0.96881473
43	MAPK15	0.94175390
44	MAP2K4	0.91441775
45	EPHA4	0.91189598
46	TYRO3	0.90209277
47	DAPK3	0.89409109
48	CAMKK2	0.87426342
49	ADRBK1	0.85618005
50	TNIK	0.82750156
51	PAK3	0.81780629
52	PDK2	0.81236079
53	TGFBR1	0.80942767
54	AURKA	0.79438049
55	PHKG2	0.78488842
56	PHKG1	0.78488842
57	PASK	0.77535554
58	MAPK13	0.77511877
59	MAP4K2	0.77477266
60	PRKCH	0.73984990
61	PLK4	0.73232316
62	PRKCQ	0.73156578
63	SGK494	0.71206901
64	SGK223	0.71206901
65	MINK1	0.70933700
66	PRKACA	0.70708030
67	NME2	0.70113918
68	CSNK2A2	0.69973752
69	PRKCZ	0.68750197
70	BRAF	0.68633604
71	CSNK1E	0.65834248
72	PRKCI	0.65643287
73	RPS6KA6	0.65575547
74	TAOK3	0.65399633
75	CDK8	0.65247381
76	ABL2	0.63856686
77	LIMK1	0.62058990
78	TSSK6	0.60382568
79	AURKB	0.58064790
80	CHEK2	0.54410959
81	CDK3	0.52812174
82	SGK1	0.51604850
83	MKNK2	0.50295115
84	RPS6KL1	0.49367319
85	RPS6KC1	0.49367319
86	PLK1	0.47967476
87	NEK2	0.47891193
88	PIM2	0.45459660
89	CAMK2A	0.45279736
90	OBSCN	0.44769022
91	CSNK2A1	0.44233247
92	CAMK1D	0.43996977
93	PLK2	0.43983106
94	PLK3	0.43785322
95	PRKG1	0.43026660
96	PRKCA	0.40946398
97	CAMK4	0.39812494
98	RPS6KA5	0.38696799
99	AKT1	0.37610824
100	CSNK1A1	0.37568507

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.87460158
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.52810773
3	Parkinsons disease_Homo sapiens_hsa05012	3.79919010
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.99255089
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.94138339
6	Huntingtons disease_Homo sapiens_hsa05016	2.80078249
7	Alzheimers disease_Homo sapiens_hsa05010	2.66132306
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.40189031
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.11572640
10	RNA polymerase_Homo sapiens_hsa03020	1.96904152
11	Protein export_Homo sapiens_hsa03060	1.90550778
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.85952192
13	Homologous recombination_Homo sapiens_hsa03440	1.82641925
14	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.61796226
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.61259238
16	Butanoate metabolism_Homo sapiens_hsa00650	1.47461084
17	Proteasome_Homo sapiens_hsa03050	1.44852715
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.42928101
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.35749523
20	RNA degradation_Homo sapiens_hsa03018	1.34598322
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.25906805
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.23201473
23	Sulfur relay system_Homo sapiens_hsa04122	1.19030336
24	Phototransduction_Homo sapiens_hsa04744	1.18355102
25	Nicotine addiction_Homo sapiens_hsa05033	1.14156643
26	Basal transcription factors_Homo sapiens_hsa03022	1.13571611
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.10528894
28	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.06878219
29	One carbon pool by folate_Homo sapiens_hsa00670	1.06605333
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.01369501
31	Asthma_Homo sapiens_hsa05310	1.01277706
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.99494225
33	Propanoate metabolism_Homo sapiens_hsa00640	0.98261917
34	Steroid biosynthesis_Homo sapiens_hsa00100	0.98132732
35	Nitrogen metabolism_Homo sapiens_hsa00910	0.95361562
36	Tryptophan metabolism_Homo sapiens_hsa00380	0.94412841
37	Mismatch repair_Homo sapiens_hsa03430	0.94291976
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93258659
39	Fat digestion and absorption_Homo sapiens_hsa04975	0.91742447
40	Basal cell carcinoma_Homo sapiens_hsa05217	0.91568962
41	Peroxisome_Homo sapiens_hsa04146	0.91377128
42	Pyrimidine metabolism_Homo sapiens_hsa00240	0.88050875
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.84384318
44	Insulin secretion_Homo sapiens_hsa04911	0.80946395
45	Caffeine metabolism_Homo sapiens_hsa00232	0.78943554
46	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.78794726
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78536879
48	Morphine addiction_Homo sapiens_hsa05032	0.78179189
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.76208741
50	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.75164381
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73588237
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73055346
53	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.70937329
54	Folate biosynthesis_Homo sapiens_hsa00790	0.70878357
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70075113
56	Olfactory transduction_Homo sapiens_hsa04740	0.69944427
57	Metabolic pathways_Homo sapiens_hsa01100	0.69418961
58	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.69364805
59	Ether lipid metabolism_Homo sapiens_hsa00565	0.66393595
60	Retinol metabolism_Homo sapiens_hsa00830	0.64585251
61	DNA replication_Homo sapiens_hsa03030	0.63974170
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63830907
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63415418
64	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.62551425
65	Fatty acid degradation_Homo sapiens_hsa00071	0.61296889
66	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.60389372
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54783323
68	Purine metabolism_Homo sapiens_hsa00230	0.54483585
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.51793584
70	GABAergic synapse_Homo sapiens_hsa04727	0.48076860
71	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.47203960
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47046257
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45838607
74	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.45801849
75	Spliceosome_Homo sapiens_hsa03040	0.45482218
76	Taste transduction_Homo sapiens_hsa04742	0.45119148
77	Serotonergic synapse_Homo sapiens_hsa04726	0.41725184
78	Axon guidance_Homo sapiens_hsa04360	0.40209603
79	Glutamatergic synapse_Homo sapiens_hsa04724	0.40091058
80	Circadian entrainment_Homo sapiens_hsa04713	0.36165181
81	RNA transport_Homo sapiens_hsa03013	0.36145852
82	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.35622538
83	Sulfur metabolism_Homo sapiens_hsa00920	0.35318946
84	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.35219479
85	Base excision repair_Homo sapiens_hsa03410	0.33554844
86	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.31372225
87	Notch signaling pathway_Homo sapiens_hsa04330	0.30362084
88	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.29269730
89	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.28323286
90	Hippo signaling pathway_Homo sapiens_hsa04390	0.28320257
91	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.28221094
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.27393427
93	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.26133629
94	Cholinergic synapse_Homo sapiens_hsa04725	0.25954048
95	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.24521311
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.24139136
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.24138170
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.24025682
99	Arginine and proline metabolism_Homo sapiens_hsa00330	0.23594747
100	Salivary secretion_Homo sapiens_hsa04970	0.23125225

RPL17P41

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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