ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	9.05512308
2	acrosome reaction (GO:0007340)	8.26977696
3	response to pheromone (GO:0019236)	7.86032164
4	fusion of sperm to egg plasma membrane (GO:0007342)	7.28514964
5	single strand break repair (GO:0000012)	6.44951479
6	rRNA methylation (GO:0031167)	6.44187079
7	spermatid development (GO:0007286)	6.29684478
8	rRNA modification (GO:0000154)	6.09463003
9	chromosome condensation (GO:0030261)	6.01455838
10	DNA packaging (GO:0006323)	5.93663752
11	sperm capacitation (GO:0048240)	5.86201200
12	protein polyglutamylation (GO:0018095)	5.81933475
13	plasma membrane fusion (GO:0045026)	5.63354026
14	cellular ketone body metabolic process (GO:0046950)	5.47840661
15	spermatid nucleus differentiation (GO:0007289)	5.24928618
16	sperm-egg recognition (GO:0035036)	5.20639039
17	multicellular organism reproduction (GO:0032504)	5.18320244
18	ketone body metabolic process (GO:1902224)	4.86420519
19	microtubule depolymerization (GO:0007019)	4.80472398
20	axonemal dynein complex assembly (GO:0070286)	4.57915310
21	microtubule severing (GO:0051013)	4.55627180
22	regulation of cilium movement (GO:0003352)	4.52869977
23	reproduction (GO:0000003)	4.52625654
24	calcium ion-dependent exocytosis (GO:0017156)	4.46293745
25	binding of sperm to zona pellucida (GO:0007339)	4.39510568
26	centriole replication (GO:0007099)	4.32280674
27	spermatogenesis (GO:0007283)	4.31076307
28	protein targeting to Golgi (GO:0000042)	4.30564170
29	male gamete generation (GO:0048232)	4.30343342
30	cell-cell recognition (GO:0009988)	4.23644991
31	establishment of protein localization to Golgi (GO:0072600)	4.14157223
32	cell wall macromolecule metabolic process (GO:0044036)	4.01353144
33	microtubule polymerization or depolymerization (GO:0031109)	4.01151405
34	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.97983270
35	gamete generation (GO:0007276)	3.96697466
36	regulation of centriole replication (GO:0046599)	3.94927858
37	epithelial cilium movement (GO:0003351)	3.91287007
38	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.91258379
39	cell wall macromolecule catabolic process (GO:0016998)	3.86004333
40	single fertilization (GO:0007338)	3.74631111
41	centriole assembly (GO:0098534)	3.68129933
42	phosphatidylethanolamine metabolic process (GO:0046337)	3.62343921
43	male meiosis I (GO:0007141)	3.60445135
44	organic cation transport (GO:0015695)	3.58796208
45	mitotic G1 DNA damage checkpoint (GO:0031571)	3.58579770
46	ATP synthesis coupled proton transport (GO:0015986)	3.57878087
47	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.57878087
48	germ cell development (GO:0007281)	3.52080718
49	glycerol ether metabolic process (GO:0006662)	3.50134847
50	motile cilium assembly (GO:0044458)	3.47509860
51	spliceosomal complex assembly (GO:0000245)	3.46835071
52	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.42397577
53	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.42245584
54	sexual reproduction (GO:0019953)	3.41102740
55	mitotic G1/S transition checkpoint (GO:0044819)	3.35434161
56	ether metabolic process (GO:0018904)	3.34848454
57	renal system development (GO:0072001)	3.33098857
58	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.31204391
59	protein localization to Golgi apparatus (GO:0034067)	3.26676772
60	regulation of Rab GTPase activity (GO:0032313)	3.26155838
61	positive regulation of Rab GTPase activity (GO:0032851)	3.26155838
62	cilium movement (GO:0003341)	3.20991789
63	male meiosis (GO:0007140)	3.20618530
64	DNA deamination (GO:0045006)	3.19786107
65	water-soluble vitamin biosynthetic process (GO:0042364)	3.19440770
66	coenzyme catabolic process (GO:0009109)	3.18445757
67	G1 DNA damage checkpoint (GO:0044783)	3.17229849
68	histone exchange (GO:0043486)	3.16170608
69	cilium or flagellum-dependent cell motility (GO:0001539)	3.15920958
70	regulation of microtubule-based movement (GO:0060632)	3.13624922
71	multicellular organismal reproductive process (GO:0048609)	3.11834613
72	piRNA metabolic process (GO:0034587)	3.11247477
73	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.07447696
74	seminiferous tubule development (GO:0072520)	3.02795490
75	RNA destabilization (GO:0050779)	2.98711158
76	fertilization (GO:0009566)	2.97324708
77	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.92104653
78	meiosis I (GO:0007127)	2.90437586
79	axoneme assembly (GO:0035082)	2.90430114
80	chaperone-mediated protein transport (GO:0072321)	2.87076449
81	chromatin silencing (GO:0006342)	2.85032874
82	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.80200924
83	histone mRNA metabolic process (GO:0008334)	2.79555073
84	negative regulation of inclusion body assembly (GO:0090084)	2.78507194
85	protein complex biogenesis (GO:0070271)	2.74496350
86	GTP biosynthetic process (GO:0006183)	2.73302511
87	mitochondrial respiratory chain complex assembly (GO:0033108)	2.71389915
88	ribosomal small subunit assembly (GO:0000028)	2.70920178
89	nephron epithelium morphogenesis (GO:0072088)	2.68097339
90	nephron tubule morphogenesis (GO:0072078)	2.68097339
91	regulation of meiosis I (GO:0060631)	2.59739829
92	positive regulation of prostaglandin secretion (GO:0032308)	2.59133922
93	cilium organization (GO:0044782)	2.58964492
94	regulation of transcription involved in cell fate commitment (GO:0060850)	2.58750704
95	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.56456945
96	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.53625186
97	cilium assembly (GO:0042384)	2.53238055
98	proteasome assembly (GO:0043248)	2.53018441
99	cell differentiation involved in metanephros development (GO:0072202)	2.51991245
100	spinal cord motor neuron differentiation (GO:0021522)	2.51387360

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.43883014
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.54397052
3	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.78835582
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.74872547
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.37025520
6	FUS_26573619_Chip-Seq_HEK293_Human	2.29182527
7	CBP_20019798_ChIP-Seq_JUKART_Human	2.16141885
8	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.16141885
9	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.15816753
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.15651106
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.15151648
12	VDR_22108803_ChIP-Seq_LS180_Human	2.08305766
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.07493858
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.00954033
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.89346777
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.83666068
17	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.81367287
18	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.81367287
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.79716602
20	ERG_20517297_ChIP-Seq_VCAP_Human	1.72420183
21	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.67709798
22	P300_19829295_ChIP-Seq_ESCs_Human	1.66898419
23	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.66800955
24	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.66001860
25	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.64407428
26	NANOG_20526341_ChIP-Seq_ESCs_Human	1.63732997
27	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.62625366
28	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.61815878
29	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.60373210
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.59109397
31	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.57225438
32	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.56861858
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.55923709
34	ERA_21632823_ChIP-Seq_H3396_Human	1.54761199
35	MYC_19829295_ChIP-Seq_ESCs_Human	1.54756540
36	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.53638724
37	TAF2_19829295_ChIP-Seq_ESCs_Human	1.50037628
38	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49388344
39	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.48810085
40	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.47756182
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.47521516
42	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.46273261
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43964910
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43964910
45	RBPJ_21746931_ChIP-Seq_IB4_Human	1.41603220
46	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.41295146
47	AR_25329375_ChIP-Seq_VCAP_Human	1.38855682
48	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.37919817
49	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.36989775
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35664269
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35664269
52	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.33566103
53	TAF15_26573619_Chip-Seq_HEK293_Human	1.32426088
54	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.32303037
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29031739
56	ETV1_20927104_ChIP-Seq_GIST48_Human	1.28608725
57	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.26786431
58	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25691179
59	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.25171225
60	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.24372793
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24217301
62	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.23155237
63	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22988662
64	RAC3_21632823_ChIP-Seq_H3396_Human	1.22574318
65	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.22076389
66	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.21660154
67	PHF8_20622853_ChIP-Seq_HELA_Human	1.19991896
68	AR_20517297_ChIP-Seq_VCAP_Human	1.17648366
69	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.17235111
70	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.15885554
71	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.15290562
72	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15018724
73	OCT4_20526341_ChIP-Seq_ESCs_Human	1.14562638
74	NFYB_21822215_ChIP-Seq_K562_Human	1.13818283
75	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.13259436
76	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.13176102
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12640221
78	NCOR_22424771_ChIP-Seq_293T_Human	1.12632185
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12378112
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11114811
81	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.10966712
82	HOXB7_26014856_ChIP-Seq_BT474_Human	1.10956656
83	P53_21459846_ChIP-Seq_SAOS-2_Human	1.10351770
84	TP53_22573176_ChIP-Seq_HFKS_Human	1.09476676
85	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.09381260
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08921076
87	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.08489727
88	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08321840
89	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08073270
90	AR_21572438_ChIP-Seq_LNCaP_Human	1.07326008
91	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.07194464
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07184991
93	SMAD4_21799915_ChIP-Seq_A2780_Human	1.07118396
94	MYC_18940864_ChIP-ChIP_HL60_Human	1.06215978
95	CTCF_20526341_ChIP-Seq_ESCs_Human	1.05128783
96	BCAT_22108803_ChIP-Seq_LS180_Human	1.04459149
97	E2F1_20622854_ChIP-Seq_HELA_Human	1.03160195
98	CEBPB_22108803_ChIP-Seq_LS180_Human	1.02858115
99	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.02523869
100	BCL6_27268052_Chip-Seq_Bcells_Human	1.02465384

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	7.74185098
2	MP0006292_abnormal_olfactory_placode	4.00843942
3	MP0003878_abnormal_ear_physiology	3.50914105
4	MP0005377_hearing/vestibular/ear_phenot	3.50914105
5	MP0005670_abnormal_white_adipose	3.06461974
6	MP0008877_abnormal_DNA_methylation	2.93388140
7	MP0003698_abnormal_male_reproductive	2.79387433
8	MP0001929_abnormal_gametogenesis	2.54136502
9	MP0003646_muscle_fatigue	2.38879173
10	MP0005379_endocrine/exocrine_gland_phen	2.20415731
11	MP0003011_delayed_dark_adaptation	2.10287641
12	MP0003718_maternal_effect	1.98415910
13	MP0001873_stomach_inflammation	1.95016418
14	MP0001485_abnormal_pinna_reflex	1.90995839
15	MP0003787_abnormal_imprinting	1.81487756
16	MP0008789_abnormal_olfactory_epithelium	1.80010018
17	MP0004142_abnormal_muscle_tone	1.73187861
18	MP0000566_synostosis	1.67363900
19	MP0002938_white_spotting	1.66699139
20	MP0008058_abnormal_DNA_repair	1.66577286
21	MP0002837_dystrophic_cardiac_calcinosis	1.61568078
22	MP0001348_abnormal_lacrimal_gland	1.58342828
23	MP0002234_abnormal_pharynx_morphology	1.55371370
24	MP0002161_abnormal_fertility/fecundity	1.52369351
25	MP0005551_abnormal_eye_electrophysiolog	1.52134309
26	MP0001984_abnormal_olfaction	1.52126948
27	MP0009379_abnormal_foot_pigmentation	1.48894404
28	MP0008872_abnormal_physiological_respon	1.48751019
29	MP0001968_abnormal_touch/_nociception	1.39270951
30	MP0002138_abnormal_hepatobiliary_system	1.35635007
31	MP0002210_abnormal_sex_determination	1.34910190
32	MP0001486_abnormal_startle_reflex	1.34642651
33	MP0009053_abnormal_anal_canal	1.33021184
34	MP0000372_irregular_coat_pigmentation	1.28868887
35	MP0005253_abnormal_eye_physiology	1.25171577
36	MP0006072_abnormal_retinal_apoptosis	1.21365225
37	MP0005645_abnormal_hypothalamus_physiol	1.21194371
38	MP0005499_abnormal_olfactory_system	1.21150598
39	MP0005394_taste/olfaction_phenotype	1.21150598
40	MP0001963_abnormal_hearing_physiology	1.19798924
41	MP0000678_abnormal_parathyroid_gland	1.18910074
42	MP0001145_abnormal_male_reproductive	1.17984995
43	MP0008875_abnormal_xenobiotic_pharmacok	1.16536455
44	MP0000653_abnormal_sex_gland	1.16003320
45	MP0002102_abnormal_ear_morphology	1.15931485
46	MP0008995_early_reproductive_senescence	1.13153952
47	MP0005408_hypopigmentation	1.13134932
48	MP0001293_anophthalmia	1.13065103
49	MP0006276_abnormal_autonomic_nervous	1.11861594
50	MP0002249_abnormal_larynx_morphology	1.11362531
51	MP0010307_abnormal_tumor_latency	1.10824143
52	MP0002282_abnormal_trachea_morphology	1.10609468
53	MP0003121_genomic_imprinting	1.06468287
54	MP0000049_abnormal_middle_ear	1.05276080
55	MP0005248_abnormal_Harderian_gland	1.04225232
56	MP0005636_abnormal_mineral_homeostasis	1.03650912
57	MP0005310_abnormal_salivary_gland	1.02938924
58	MP0005646_abnormal_pituitary_gland	1.02899906
59	MP0003195_calcinosis	1.02641732
60	MP0002876_abnormal_thyroid_physiology	1.02213522
61	MP0002254_reproductive_system_inflammat	1.01906382
62	MP0002163_abnormal_gland_morphology	1.01581194
63	MP0002272_abnormal_nervous_system	1.00567958
64	MP0005423_abnormal_somatic_nervous	0.97338128
65	MP0000026_abnormal_inner_ear	0.97325649
66	MP0000631_abnormal_neuroendocrine_gland	0.95522546
67	MP0001765_abnormal_ion_homeostasis	0.94016336
68	MP0004742_abnormal_vestibular_system	0.92074829
69	MP0001986_abnormal_taste_sensitivity	0.91527301
70	MP0002735_abnormal_chemical_nociception	0.91394030
71	MP0000613_abnormal_salivary_gland	0.90197320
72	MP0001905_abnormal_dopamine_level	0.89702285
73	MP0001764_abnormal_homeostasis	0.88684347
74	MP0009697_abnormal_copulation	0.87893093
75	MP0005332_abnormal_amino_acid	0.83711159
76	MP0009745_abnormal_behavioral_response	0.82676660
77	MP0005395_other_phenotype	0.81821361
78	MP0002822_catalepsy	0.80196701
79	MP0001440_abnormal_grooming_behavior	0.78913933
80	MP0002736_abnormal_nociception_after	0.78786528
81	MP0002229_neurodegeneration	0.77476072
82	MP0002557_abnormal_social/conspecific_i	0.77113725
83	MP0003936_abnormal_reproductive_system	0.77017475
84	MP0003880_abnormal_central_pattern	0.76717728
85	MP0001835_abnormal_antigen_presentation	0.75792612
86	MP0005084_abnormal_gallbladder_morpholo	0.73529747
87	MP0003122_maternal_imprinting	0.71968487
88	MP0003137_abnormal_impulse_conducting	0.70848766
89	MP0001501_abnormal_sleep_pattern	0.70829493
90	MP0004782_abnormal_surfactant_physiolog	0.69380647
91	MP0003186_abnormal_redox_activity	0.67892152
92	MP0005671_abnormal_response_to	0.67500138
93	MP0005195_abnormal_posterior_eye	0.65725346
94	MP0002693_abnormal_pancreas_physiology	0.65713169
95	MP0005167_abnormal_blood-brain_barrier	0.64760482
96	MP0003938_abnormal_ear_development	0.61603266
97	MP0004085_abnormal_heartbeat	0.59978167
98	MP0003119_abnormal_digestive_system	0.59828238
99	MP0005391_vision/eye_phenotype	0.58472606
100	MP0001529_abnormal_vocalization	0.57988487

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	4.83280457
2	Chronic hepatic failure (HP:0100626)	4.09081612
3	Attenuation of retinal blood vessels (HP:0007843)	4.00114435
4	Abnormality of the labia minora (HP:0012880)	3.97931029
5	Absent/shortened dynein arms (HP:0200106)	3.85076814
6	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.85076814
7	Bony spicule pigmentary retinopathy (HP:0007737)	3.66952686
8	Renal Fanconi syndrome (HP:0001994)	3.59540677
9	Nephronophthisis (HP:0000090)	3.57520329
10	Progressive cerebellar ataxia (HP:0002073)	3.47368433
11	Cystic liver disease (HP:0006706)	3.43063329
12	Abnormal rod and cone electroretinograms (HP:0008323)	3.39178462
13	Acute necrotizing encephalopathy (HP:0006965)	3.29239116
14	Mitochondrial inheritance (HP:0001427)	3.13246362
15	Abnormal drinking behavior (HP:0030082)	3.11985312
16	Polydipsia (HP:0001959)	3.11985312
17	Pancreatic cysts (HP:0001737)	3.11710930
18	Abnormality of macular pigmentation (HP:0008002)	3.07402538
19	Pancreatic fibrosis (HP:0100732)	3.05101008
20	Acute encephalopathy (HP:0006846)	2.98913831
21	Tubulointerstitial nephritis (HP:0001970)	2.96012937
22	Abnormality of the renal medulla (HP:0100957)	2.90982814
23	Glycosuria (HP:0003076)	2.86139176
24	Abnormality of urine glucose concentration (HP:0011016)	2.86139176
25	Abnormal ciliary motility (HP:0012262)	2.84155992
26	Abnormal respiratory motile cilium morphology (HP:0005938)	2.81313903
27	Abnormal respiratory epithelium morphology (HP:0012253)	2.81313903
28	Tubular atrophy (HP:0000092)	2.78215981
29	Increased hepatocellular lipid droplets (HP:0006565)	2.77132026
30	Abnormal mitochondria in muscle tissue (HP:0008316)	2.74042968
31	Progressive macrocephaly (HP:0004481)	2.72481310
32	Hepatocellular necrosis (HP:0001404)	2.71422603
33	Molar tooth sign on MRI (HP:0002419)	2.71088454
34	Abnormality of midbrain morphology (HP:0002418)	2.71088454
35	Pendular nystagmus (HP:0012043)	2.65666622
36	Increased CSF lactate (HP:0002490)	2.63593152
37	Abnormal respiratory motile cilium physiology (HP:0012261)	2.60650482
38	Lipid accumulation in hepatocytes (HP:0006561)	2.59314919
39	Polyuria (HP:0000103)	2.58891929
40	Abnormal urine output (HP:0012590)	2.58888848
41	Optic disc pallor (HP:0000543)	2.52189491
42	Azoospermia (HP:0000027)	2.51462163
43	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.47306639
44	Hepatic necrosis (HP:0002605)	2.44111434
45	True hermaphroditism (HP:0010459)	2.37314860
46	Optic nerve hypoplasia (HP:0000609)	2.35065280
47	Potter facies (HP:0002009)	2.34969009
48	Facial shape deformation (HP:0011334)	2.34969009
49	Abnormality of renal resorption (HP:0011038)	2.34934552
50	Abnormal spermatogenesis (HP:0008669)	2.31387818
51	Generalized aminoaciduria (HP:0002909)	2.28730647
52	Abnormality of renal excretion (HP:0011036)	2.27237873
53	Abnormality of cochlea (HP:0000375)	2.25447275
54	Abnormality of the aortic arch (HP:0012303)	2.25353181
55	Renal dysplasia (HP:0000110)	2.22251152
56	Gastrointestinal atresia (HP:0002589)	2.21162608
57	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.17749612
58	Cerebral edema (HP:0002181)	2.17641353
59	Congenital stationary night blindness (HP:0007642)	2.16967937
60	Delayed CNS myelination (HP:0002188)	2.12103984
61	Decreased central vision (HP:0007663)	2.11343577
62	Growth hormone deficiency (HP:0000824)	2.10264890
63	Rib fusion (HP:0000902)	2.07288543
64	Abnormality of the renal cortex (HP:0011035)	2.06658515
65	Esophageal atresia (HP:0002032)	2.06531482
66	Hyperphosphaturia (HP:0003109)	2.04420335
67	Resting tremor (HP:0002322)	2.00923723
68	Sclerocornea (HP:0000647)	1.97193144
69	Rhinitis (HP:0012384)	1.97176406
70	Infertility (HP:0000789)	1.96233298
71	Exertional dyspnea (HP:0002875)	1.95596363
72	Oligodactyly (HP:0012165)	1.93925977
73	Double outlet right ventricle (HP:0001719)	1.93392885
74	Congenital malformation of the right heart (HP:0011723)	1.93392885
75	Impulsivity (HP:0100710)	1.91605799
76	Tetany (HP:0001281)	1.90023900
77	Insulin-resistant diabetes mellitus (HP:0000831)	1.89787089
78	Tubulointerstitial abnormality (HP:0001969)	1.87371650
79	Birth length less than 3rd percentile (HP:0003561)	1.87051294
80	Congenital, generalized hypertrichosis (HP:0004540)	1.85344444
81	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.85269918
82	Intestinal atresia (HP:0011100)	1.84279866
83	Febrile seizures (HP:0002373)	1.83744479
84	Menstrual irregularities (HP:0000858)	1.83250979
85	Hypothermia (HP:0002045)	1.81402044
86	Hypoplasia of the thymus (HP:0000778)	1.80809804
87	Colon cancer (HP:0003003)	1.79159583
88	Occipital encephalocele (HP:0002085)	1.75987556
89	Congenital sensorineural hearing impairment (HP:0008527)	1.73386886
90	Medial flaring of the eyebrow (HP:0010747)	1.72827522
91	Hemiparesis (HP:0001269)	1.72700551
92	Stage 5 chronic kidney disease (HP:0003774)	1.70795223
93	Respiratory distress (HP:0002098)	1.70145869
94	Cone-rod dystrophy (HP:0000548)	1.68847361
95	Shawl scrotum (HP:0000049)	1.68622111
96	Abnormality of cells of the erythroid lineage (HP:0012130)	1.68607593
97	Constricted visual fields (HP:0001133)	1.67096468
98	Enlarged epiphyses (HP:0010580)	1.66755549
99	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.65768238
100	Abnormal biliary tract physiology (HP:0012439)	1.64592139

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	5.67286387
2	MAP4K2	3.50329198
3	INSRR	2.87591409
4	VRK2	2.70264936
5	NUAK1	2.46028446
6	WNK4	2.26108592
7	NME1	2.24229281
8	ZAK	2.19983668
9	TESK1	2.11576595
10	PLK2	2.09588636
11	TXK	2.06996752
12	FRK	2.03723395
13	STK38L	2.03655910
14	BMPR1B	1.96542527
15	DDR2	1.92871493
16	STK39	1.89836952
17	WNK3	1.89474477
18	ADRBK2	1.72645782
19	GRK1	1.56827056
20	TLK1	1.46374886
21	TIE1	1.44934573
22	OXSR1	1.41813314
23	MST4	1.39900421
24	PNCK	1.38913356
25	BMPR2	1.38730678
26	VRK1	1.37174973
27	MUSK	1.35632974
28	PIK3CG	1.30461629
29	BCKDK	1.29026388
30	CAMK1G	1.26346983
31	PRKD3	1.25390905
32	STK38	1.24060684
33	TAF1	1.22234844
34	TEC	1.17260511
35	DYRK2	1.14748000
36	STK16	1.12721100
37	WNK1	1.12588231
38	PHKG2	0.97290231
39	PHKG1	0.97290231
40	BRSK2	0.95428331
41	SRPK1	0.95216415
42	MAPK15	0.95111620
43	TAOK3	0.92760213
44	MAP3K4	0.79981552
45	TNIK	0.79526346
46	PAK3	0.79304921
47	CDK7	0.77169016
48	PAK6	0.76626177
49	PTK2B	0.72238475
50	MAP3K9	0.71331059
51	PINK1	0.71179179
52	PLK3	0.70776607
53	PRKG1	0.69897678
54	CDC7	0.66620689
55	AKT3	0.62837415
56	PLK1	0.62383804
57	IKBKB	0.61649812
58	PRKCG	0.58459326
59	PRKAA2	0.58218695
60	CAMK1D	0.54429110
61	DAPK2	0.53923017
62	BRD4	0.52382698
63	SGK223	0.51624441
64	SGK494	0.51624441
65	CCNB1	0.50967246
66	ITK	0.50335796
67	ACVR1B	0.49894188
68	TSSK6	0.48035437
69	MAPK13	0.48002781
70	STK3	0.46960768
71	LATS1	0.46827034
72	SGK2	0.45325106
73	PRKACA	0.41211121
74	ATM	0.40456772
75	PRKCE	0.38802149
76	PASK	0.38511395
77	CAMK1	0.36166348
78	SGK1	0.35483269
79	ERBB3	0.35346629
80	CSNK1G3	0.34955190
81	MAP2K6	0.34331202
82	EIF2AK2	0.34138840
83	GRK5	0.34078025
84	AKT2	0.33559423
85	PRKDC	0.33389963
86	RIPK4	0.33253308
87	PRKACB	0.31990160
88	CSNK1G1	0.31277669
89	CSNK1E	0.31123311
90	CDK2	0.30794528
91	CSNK2A2	0.30505601
92	CSNK1G2	0.30314588
93	PRKCA	0.30090922
94	RPS6KA1	0.29912779
95	NEK6	0.28871790
96	DYRK3	0.28658686
97	MAPKAPK5	0.28577093
98	PDK1	0.28104892
99	ROCK1	0.27631080
100	TNK2	0.27353745

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.06509809
2	Protein export_Homo sapiens_hsa03060	4.07016327
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.03956934
4	Ribosome_Homo sapiens_hsa03010	2.84699700
5	Homologous recombination_Homo sapiens_hsa03440	2.70212456
6	Proteasome_Homo sapiens_hsa03050	2.62562048
7	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.36515821
8	Parkinsons disease_Homo sapiens_hsa05012	2.35405986
9	Butanoate metabolism_Homo sapiens_hsa00650	2.25143539
10	Mismatch repair_Homo sapiens_hsa03430	2.13664683
11	Huntingtons disease_Homo sapiens_hsa05016	2.00427549
12	RNA polymerase_Homo sapiens_hsa03020	1.99844948
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.92777377
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.90400163
15	Olfactory transduction_Homo sapiens_hsa04740	1.81855009
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.75971141
17	Allograft rejection_Homo sapiens_hsa05330	1.75297734
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.74815946
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.73689718
20	Basal transcription factors_Homo sapiens_hsa03022	1.72550673
21	Graft-versus-host disease_Homo sapiens_hsa05332	1.68779425
22	Caffeine metabolism_Homo sapiens_hsa00232	1.62145772
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.54821762
24	Alzheimers disease_Homo sapiens_hsa05010	1.53287299
25	Propanoate metabolism_Homo sapiens_hsa00640	1.47888540
26	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.38960158
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.35099230
28	Non-homologous end-joining_Homo sapiens_hsa03450	1.34131957
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.31059201
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.30994291
31	Phototransduction_Homo sapiens_hsa04744	1.30002836
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.27002958
33	Fatty acid degradation_Homo sapiens_hsa00071	1.18150983
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.14201941
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.13375831
36	RNA degradation_Homo sapiens_hsa03018	1.09847659
37	Retinol metabolism_Homo sapiens_hsa00830	1.06839579
38	RNA transport_Homo sapiens_hsa03013	1.06532511
39	Tryptophan metabolism_Homo sapiens_hsa00380	1.06212083
40	Asthma_Homo sapiens_hsa05310	1.03185753
41	Purine metabolism_Homo sapiens_hsa00230	0.97101583
42	Antigen processing and presentation_Homo sapiens_hsa04612	0.93237712
43	Peroxisome_Homo sapiens_hsa04146	0.91329619
44	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.88598752
45	Pyrimidine metabolism_Homo sapiens_hsa00240	0.86254192
46	One carbon pool by folate_Homo sapiens_hsa00670	0.85888384
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84646199
48	Selenocompound metabolism_Homo sapiens_hsa00450	0.84220428
49	DNA replication_Homo sapiens_hsa03030	0.83739862
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.83195805
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.79849519
52	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.79700559
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76800481
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.76692367
55	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.75770879
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74141568
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73379301
58	Fatty acid metabolism_Homo sapiens_hsa01212	0.69433543
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68947495
60	Metabolic pathways_Homo sapiens_hsa01100	0.68445488
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.68116032
62	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.67680518
63	Pyruvate metabolism_Homo sapiens_hsa00620	0.67515193
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66577924
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65981671
66	Nitrogen metabolism_Homo sapiens_hsa00910	0.65692477
67	Taste transduction_Homo sapiens_hsa04742	0.65488023
68	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.61757413
69	Nicotine addiction_Homo sapiens_hsa05033	0.61549901
70	Ether lipid metabolism_Homo sapiens_hsa00565	0.58794951
71	Arginine and proline metabolism_Homo sapiens_hsa00330	0.54981439
72	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.54065235
73	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.51192474
74	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50791232
75	Insulin secretion_Homo sapiens_hsa04911	0.50265406
76	Spliceosome_Homo sapiens_hsa03040	0.48781483
77	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.48548118
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47825063
79	Regulation of autophagy_Homo sapiens_hsa04140	0.45154116
80	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.44826629
81	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.41836958
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41766104
83	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40020537
84	Morphine addiction_Homo sapiens_hsa05032	0.39880741
85	Basal cell carcinoma_Homo sapiens_hsa05217	0.39064542
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37966351
87	Sulfur relay system_Homo sapiens_hsa04122	0.36232038
88	Salivary secretion_Homo sapiens_hsa04970	0.31896912
89	Tyrosine metabolism_Homo sapiens_hsa00350	0.31290708
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.29992770
91	Base excision repair_Homo sapiens_hsa03410	0.29625792
92	Arginine biosynthesis_Homo sapiens_hsa00220	0.29575252
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.29229877
94	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.29083067
95	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.28073699
96	Folate biosynthesis_Homo sapiens_hsa00790	0.27090104
97	Mineral absorption_Homo sapiens_hsa04978	0.26806944
98	Protein digestion and absorption_Homo sapiens_hsa04974	0.26606836
99	ABC transporters_Homo sapiens_hsa02010	0.26604302
100	Glutathione metabolism_Homo sapiens_hsa00480	0.24482260

RPL17P43

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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