RPL17P44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)9.08346509
2ribosomal small subunit assembly (GO:0000028)8.85409709
3translational termination (GO:0006415)8.64691967
4ribosomal small subunit biogenesis (GO:0042274)7.44261867
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.20211061
6protein targeting to ER (GO:0045047)7.17050063
7translational elongation (GO:0006414)7.10502617
8cotranslational protein targeting to membrane (GO:0006613)7.08139031
9establishment of protein localization to endoplasmic reticulum (GO:0072599)6.85243010
10protein localization to endoplasmic reticulum (GO:0070972)6.67652496
11cellular protein complex disassembly (GO:0043624)6.58200166
12viral life cycle (GO:0019058)6.49446581
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.35749969
14maturation of SSU-rRNA (GO:0030490)6.33128701
15regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.55205511
16protein complex disassembly (GO:0043241)5.49149589
17translational initiation (GO:0006413)5.34881012
18macromolecular complex disassembly (GO:0032984)5.17206874
19behavioral response to nicotine (GO:0035095)4.93260813
20protein targeting to membrane (GO:0006612)4.79322136
21cell wall macromolecule metabolic process (GO:0044036)4.60915932
22ribosomal large subunit biogenesis (GO:0042273)4.56511045
23chaperone-mediated protein transport (GO:0072321)4.40973054
24embryonic body morphogenesis (GO:0010172)4.36835944
25nuclear-transcribed mRNA catabolic process (GO:0000956)4.34550825
26energy coupled proton transport, down electrochemical gradient (GO:0015985)4.31445400
27ATP synthesis coupled proton transport (GO:0015986)4.31445400
28translation (GO:0006412)4.12800318
29mRNA catabolic process (GO:0006402)4.08450796
30nonmotile primary cilium assembly (GO:0035058)4.02583484
31activation of MAPKKK activity (GO:0000185)4.00871368
32pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.98256486
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.97411327
34body morphogenesis (GO:0010171)3.80648070
35protein neddylation (GO:0045116)3.78159185
36RNA catabolic process (GO:0006401)3.76596061
37mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.75691491
38axoneme assembly (GO:0035082)3.75666601
39leukocyte aggregation (GO:0070486)3.64933805
40pyrimidine nucleobase catabolic process (GO:0006208)3.63279147
41protein complex biogenesis (GO:0070271)3.61864015
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.53485353
43NADH dehydrogenase complex assembly (GO:0010257)3.53485353
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.53485353
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.50120687
46negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.49486402
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.47415364
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.47415364
49cardiovascular system development (GO:0072358)3.44435442
50respiratory electron transport chain (GO:0022904)3.42432431
51DNA deamination (GO:0045006)3.40383788
52electron transport chain (GO:0022900)3.37982852
53establishment of protein localization to mitochondrial membrane (GO:0090151)3.35609992
54pyrimidine nucleotide catabolic process (GO:0006244)3.33500358
55meiotic chromosome segregation (GO:0045132)3.21677778
56establishment of protein localization to membrane (GO:0090150)3.18761454
57cellular component biogenesis (GO:0044085)3.16667884
58ribonucleoprotein complex biogenesis (GO:0022613)3.12963560
59negative regulation of T cell differentiation in thymus (GO:0033085)3.09301220
60mitochondrial respiratory chain complex assembly (GO:0033108)3.06694553
61protein targeting (GO:0006605)3.06312920
62positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.03069000
63gonadal mesoderm development (GO:0007506)3.00625270
64cilium movement (GO:0003341)2.95733676
65nucleobase catabolic process (GO:0046113)2.93658002
66water-soluble vitamin biosynthetic process (GO:0042364)2.91876227
67valine metabolic process (GO:0006573)2.91614489
68metallo-sulfur cluster assembly (GO:0031163)2.87580145
69iron-sulfur cluster assembly (GO:0016226)2.87580145
70GTP biosynthetic process (GO:0006183)2.86026782
71establishment of protein localization to organelle (GO:0072594)2.84904786
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84351777
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78411229
74male meiosis I (GO:0007141)2.77416577
75substrate-independent telencephalic tangential migration (GO:0021826)2.76541724
76substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.76541724
77cellular response to dexamethasone stimulus (GO:0071549)2.73712612
78positive regulation of respiratory burst (GO:0060267)2.71487246
79regulation of cilium movement (GO:0003352)2.71257740
80cell proliferation in forebrain (GO:0021846)2.67883681
81production of molecular mediator involved in inflammatory response (GO:0002532)2.63412256
82purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.60451477
83transcription elongation from RNA polymerase III promoter (GO:0006385)2.58740080
84termination of RNA polymerase III transcription (GO:0006386)2.58740080
85protein localization to membrane (GO:0072657)2.57012550
86purine nucleoside triphosphate biosynthetic process (GO:0009145)2.56545293
87synaptic transmission, cholinergic (GO:0007271)2.56176523
88epithelial cilium movement (GO:0003351)2.56159551
89regulation of regulatory T cell differentiation (GO:0045589)2.55213159
90pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.54593652
91positive regulation of T cell apoptotic process (GO:0070234)2.52954716
92response to dexamethasone (GO:0071548)2.52786021
93ATP biosynthetic process (GO:0006754)2.52375065
94establishment of planar polarity (GO:0001736)2.51368973
95establishment of tissue polarity (GO:0007164)2.51368973
96base-excision repair, AP site formation (GO:0006285)2.51362086
97resolution of meiotic recombination intermediates (GO:0000712)2.49840775
98positive regulation of defense response to virus by host (GO:0002230)2.47471438
99glucosamine-containing compound catabolic process (GO:1901072)2.43251446
100negative regulation of macrophage differentiation (GO:0045650)2.41994093

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.42118627
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.12316431
3GABP_17652178_ChIP-ChIP_JURKAT_Human2.82445738
4ZNF274_21170338_ChIP-Seq_K562_Hela2.61164326
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.58190573
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46860919
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.26376292
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18765565
9VDR_22108803_ChIP-Seq_LS180_Human2.16168100
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03629812
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99504036
12ETS1_20019798_ChIP-Seq_JURKAT_Human1.93114955
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91944018
14CBX2_27304074_Chip-Seq_ESCs_Mouse1.88674668
15BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86959684
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.78802584
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76392996
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75022358
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.71770740
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69635970
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64329987
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.63931424
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.61757320
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.54742936
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52335548
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50203972
27GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.47418151
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.46422142
29STAT1_20625510_ChIP-Seq_HELA_Human1.43958462
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41925660
31CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37506500
32FOXA1_25329375_ChIP-Seq_VCAP_Human1.37254838
33FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37254838
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37042216
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36625392
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.36205247
37TAF2_19829295_ChIP-Seq_ESCs_Human1.35983875
38GATA3_21878914_ChIP-Seq_MCF-7_Human1.35376323
39TDRD3_21172665_ChIP-Seq_MCF-7_Human1.34429617
40ERA_21632823_ChIP-Seq_H3396_Human1.32283544
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31577795
42MYC_19829295_ChIP-Seq_ESCs_Human1.31236633
43VDR_23849224_ChIP-Seq_CD4+_Human1.29983818
44AR_20517297_ChIP-Seq_VCAP_Human1.29874110
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29821552
46EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27909715
47BCL6_27268052_Chip-Seq_Bcells_Human1.27761696
48TP53_22573176_ChIP-Seq_HFKS_Human1.26616974
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26418918
50REST_21632747_ChIP-Seq_MESCs_Mouse1.25832309
51FOXH1_21741376_ChIP-Seq_ESCs_Human1.25746442
52NCOR_22424771_ChIP-Seq_293T_Human1.24077357
53NANOG_20526341_ChIP-Seq_ESCs_Human1.23723280
54E2F1_20622854_ChIP-Seq_HELA_Human1.23316081
55YY1_22570637_ChIP-Seq_MALME-3M_Human1.22872578
56EWS_26573619_Chip-Seq_HEK293_Human1.18024638
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15613588
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15088904
59AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14956692
60CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14471706
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14315960
62IGF1R_20145208_ChIP-Seq_DFB_Human1.12678469
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12208142
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11552761
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11159721
66EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.09764324
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09648124
68RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09219013
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.08869687
70RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08418208
71RNF2_27304074_Chip-Seq_NSC_Mouse1.07356679
72CTCF_20526341_ChIP-Seq_ESCs_Human1.07294818
73MYC_18940864_ChIP-ChIP_HL60_Human1.06104850
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04124421
75GATA6_21074721_ChIP-Seq_CACO-2_Human1.03754842
76GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03092569
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03029132
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02722743
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02164199
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.00877144
81SOX2_21211035_ChIP-Seq_LN229_Human1.00612162
82EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99837433
83RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99837433
84FOXP3_21729870_ChIP-Seq_TREG_Human0.99662530
85CTCF_27219007_Chip-Seq_Bcells_Human0.99639588
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98869954
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98145312
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.97995822
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97911086
90REST_18959480_ChIP-ChIP_MESCs_Mouse0.97820986
91P300_27268052_Chip-Seq_Bcells_Human0.95651804
92ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94921863
93BCAT_22108803_ChIP-Seq_LS180_Human0.94437373
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93278105
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92817504
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92508466
97FUS_26573619_Chip-Seq_HEK293_Human0.92349021
98P53_21459846_ChIP-Seq_SAOS-2_Human0.92118430
99IRF1_19129219_ChIP-ChIP_H3396_Human0.90473431
100FOXP1_21924763_ChIP-Seq_HESCs_Human0.89762086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation8.53969787
2MP0006292_abnormal_olfactory_placode4.32048657
3MP0008789_abnormal_olfactory_epithelium3.58919232
4MP0003646_muscle_fatigue3.00188250
5MP0005499_abnormal_olfactory_system2.79551959
6MP0005394_taste/olfaction_phenotype2.79551959
7MP0003787_abnormal_imprinting2.37071943
8MP0002638_abnormal_pupillary_reflex2.33565642
9MP0002837_dystrophic_cardiac_calcinosis2.29886944
10MP0002163_abnormal_gland_morphology2.14786481
11MP0005551_abnormal_eye_electrophysiolog2.11129450
12MP0005623_abnormal_meninges_morphology2.09600392
13MP0005671_abnormal_response_to1.89214862
14MP0008877_abnormal_DNA_methylation1.87375459
15MP0000750_abnormal_muscle_regeneration1.83443038
16MP0002938_white_spotting1.75313046
17MP0008872_abnormal_physiological_respon1.66600217
18MP0004142_abnormal_muscle_tone1.63733379
19MP0000372_irregular_coat_pigmentation1.63007768
20MP0005645_abnormal_hypothalamus_physiol1.60800649
21MP0004145_abnormal_muscle_electrophysio1.56503695
22MP0003786_premature_aging1.53419717
23MP0001293_anophthalmia1.53069830
24MP0001986_abnormal_taste_sensitivity1.51160525
25MP0003121_genomic_imprinting1.42936504
26MP0008775_abnormal_heart_ventricle1.42565250
27MP0006072_abnormal_retinal_apoptosis1.34713529
28MP0002653_abnormal_ependyma_morphology1.32229105
29MP0005423_abnormal_somatic_nervous1.32209829
30MP0005379_endocrine/exocrine_gland_phen1.31528528
31MP0000631_abnormal_neuroendocrine_gland1.23597108
32MP0001905_abnormal_dopamine_level1.20665443
33MP0006276_abnormal_autonomic_nervous1.20567368
34MP0001485_abnormal_pinna_reflex1.19737314
35MP0003880_abnormal_central_pattern1.19375395
36MP0005389_reproductive_system_phenotype1.19094356
37MP0000685_abnormal_immune_system1.17561933
38MP0000049_abnormal_middle_ear1.12638211
39MP0009745_abnormal_behavioral_response1.12426809
40MP0002733_abnormal_thermal_nociception1.12213100
41MP0001970_abnormal_pain_threshold1.11947666
42MP0008995_early_reproductive_senescence1.11481608
43MP0005646_abnormal_pituitary_gland1.11431191
44MP0001835_abnormal_antigen_presentation1.11268517
45MP0005195_abnormal_posterior_eye1.11220018
46MP0000778_abnormal_nervous_system1.10643567
47MP0001919_abnormal_reproductive_system1.07801010
48MP0002272_abnormal_nervous_system1.06207493
49MP0001968_abnormal_touch/_nociception1.05981621
50MP0003878_abnormal_ear_physiology1.04310139
51MP0005377_hearing/vestibular/ear_phenot1.04310139
52MP0002095_abnormal_skin_pigmentation1.03162238
53MP0004147_increased_porphyrin_level1.00809568
54MP0009384_cardiac_valve_regurgitation0.96445645
55MP0002736_abnormal_nociception_after0.94329031
56MP0004885_abnormal_endolymph0.93682443
57MP0003122_maternal_imprinting0.93080342
58MP0008875_abnormal_xenobiotic_pharmacok0.92439054
59MP0002160_abnormal_reproductive_system0.91507237
60MP0003806_abnormal_nucleotide_metabolis0.90650676
61MP0005410_abnormal_fertilization0.88942438
62MP0003011_delayed_dark_adaptation0.88872335
63MP0001440_abnormal_grooming_behavior0.88859975
64MP0003123_paternal_imprinting0.88393977
65MP0001348_abnormal_lacrimal_gland0.88068956
66MP0001529_abnormal_vocalization0.86326862
67MP0002572_abnormal_emotion/affect_behav0.85282444
68MP0009764_decreased_sensitivity_to0.84812531
69MP0002876_abnormal_thyroid_physiology0.83519568
70MP0003186_abnormal_redox_activity0.82823022
71MP0002752_abnormal_somatic_nervous0.82751582
72MP0002557_abnormal_social/conspecific_i0.82066230
73MP0009046_muscle_twitch0.81923553
74MP0002233_abnormal_nose_morphology0.80924798
75MP0002102_abnormal_ear_morphology0.80800794
76MP0010386_abnormal_urinary_bladder0.80107950
77MP0003763_abnormal_thymus_physiology0.79571895
78MP0002277_abnormal_respiratory_mucosa0.79143788
79MP0001663_abnormal_digestive_system0.77839574
80MP0002184_abnormal_innervation0.77715914
81MP0001486_abnormal_startle_reflex0.77596504
82MP0001765_abnormal_ion_homeostasis0.77471049
83MP0002067_abnormal_sensory_capabilities0.75918728
84MP0001800_abnormal_humoral_immune0.72304066
85MP0002234_abnormal_pharynx_morphology0.68859791
86MP0005253_abnormal_eye_physiology0.67269839
87MP0009250_abnormal_appendicular_skeleto0.66270218
88MP0002822_catalepsy0.65817246
89MP0000955_abnormal_spinal_cord0.65813273
90MP0002063_abnormal_learning/memory/cond0.65692103
91MP0000026_abnormal_inner_ear0.65220069
92MP0002210_abnormal_sex_determination0.65206754
93MP0005387_immune_system_phenotype0.64768187
94MP0001790_abnormal_immune_system0.64768187
95MP0001324_abnormal_eye_pigmentation0.64767932
96MP0002734_abnormal_mechanical_nocicepti0.64542346
97MP0003283_abnormal_digestive_organ0.63221529
98MP0003698_abnormal_male_reproductive0.62967402
99MP0009333_abnormal_splenocyte_physiolog0.62508774
100MP0008058_abnormal_DNA_repair0.62182546

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)5.63524202
2Cerebellar dysplasia (HP:0007033)4.99759768
3Aplasia/Hypoplasia of the sacrum (HP:0008517)4.90535264
4Reticulocytopenia (HP:0001896)4.89173151
5Retinal atrophy (HP:0001105)4.53918746
6Abnormality of cells of the erythroid lineage (HP:0012130)4.48207701
7Hypoplasia of the pons (HP:0012110)4.19168914
8Retinal dysplasia (HP:0007973)4.14661953
9Pallor (HP:0000980)3.97428554
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.90586785
11Acute necrotizing encephalopathy (HP:0006965)3.83413778
12Abnormality of the pons (HP:0007361)3.81196894
13Abolished electroretinogram (ERG) (HP:0000550)3.63148371
14Abnormal respiratory epithelium morphology (HP:0012253)3.59529281
15Abnormal respiratory motile cilium morphology (HP:0005938)3.59529281
16Abnormal ciliary motility (HP:0012262)3.56785614
17Macrocytic anemia (HP:0001972)3.56280053
18Pancreatic cysts (HP:0001737)3.54184647
19Decreased electroretinogram (ERG) amplitude (HP:0000654)3.47180686
20Abnormal number of erythroid precursors (HP:0012131)3.42196406
21Abnormal mitochondria in muscle tissue (HP:0008316)3.34788282
22Acute encephalopathy (HP:0006846)3.29842855
23Mitochondrial inheritance (HP:0001427)3.28538065
24Abnormality of midbrain morphology (HP:0002418)3.27044914
25Molar tooth sign on MRI (HP:0002419)3.27044914
26Abnormality of DNA repair (HP:0003254)3.10085480
27Nephronophthisis (HP:0000090)3.09987702
28Progressive macrocephaly (HP:0004481)3.05756247
29Pancreatic fibrosis (HP:0100732)2.90330639
30Meningocele (HP:0002435)2.80397166
31Abnormal respiratory motile cilium physiology (HP:0012261)2.79896073
32Pendular nystagmus (HP:0012043)2.77378189
33Increased intramyocellular lipid droplets (HP:0012240)2.75646151
34Maternal diabetes (HP:0009800)2.74724121
35Increased CSF lactate (HP:0002490)2.71645170
36Abnormal rod and cone electroretinograms (HP:0008323)2.69538112
37Aplasia/Hypoplasia of the spleen (HP:0010451)2.63368290
38Medial flaring of the eyebrow (HP:0010747)2.58755287
39Asplenia (HP:0001746)2.58514361
40Optic disc pallor (HP:0000543)2.57000072
41Aplasia/Hypoplasia affecting the retina (HP:0008061)2.55941059
42Lipid accumulation in hepatocytes (HP:0006561)2.54317912
43Anencephaly (HP:0002323)2.54019207
44Increased hepatocellular lipid droplets (HP:0006565)2.53662979
45Severe muscular hypotonia (HP:0006829)2.53605900
46Increased muscle lipid content (HP:0009058)2.50920911
47Lissencephaly (HP:0001339)2.50545826
483-Methylglutaconic aciduria (HP:0003535)2.47651535
49Chronic sinusitis (HP:0011109)2.46573273
50Pachygyria (HP:0001302)2.39020632
51Renal Fanconi syndrome (HP:0001994)2.38671051
52Buphthalmos (HP:0000557)2.37587969
53Tubular atrophy (HP:0000092)2.34992790
54Stenosis of the external auditory canal (HP:0000402)2.32409607
55Hepatocellular necrosis (HP:0001404)2.31231196
56Attenuation of retinal blood vessels (HP:0007843)2.28636007
57IgG deficiency (HP:0004315)2.26620699
58Cerebral edema (HP:0002181)2.24388075
59Abnormality of the renal medulla (HP:0100957)2.23364433
60Poikiloderma (HP:0001029)2.22961710
61Congenital, generalized hypertrichosis (HP:0004540)2.22566951
62Postaxial foot polydactyly (HP:0001830)2.22312962
63Rectal prolapse (HP:0002035)2.15924482
64True hermaphroditism (HP:0010459)2.13754001
65Holoprosencephaly (HP:0001360)2.10741254
66Entropion (HP:0000621)2.10341263
67Elevated erythrocyte sedimentation rate (HP:0003565)2.10012799
68Hyperglycinemia (HP:0002154)2.07220856
69Decreased central vision (HP:0007663)2.06750676
70Rhinitis (HP:0012384)2.06518265
71Myelomeningocele (HP:0002475)2.05994000
72Rib fusion (HP:0000902)2.01325226
73Increased corneal curvature (HP:0100692)1.99488582
74Keratoconus (HP:0000563)1.99488582
75Myokymia (HP:0002411)1.96168687
76Cystic liver disease (HP:0006706)1.95677944
77Absent thumb (HP:0009777)1.95431636
78Aplasia/Hypoplasia of the brainstem (HP:0007362)1.93747897
79Hypoplasia of the brainstem (HP:0002365)1.93747897
80Agitation (HP:0000713)1.92067984
81Fatigue (HP:0012378)1.91504890
82Abnormal pupillary function (HP:0007686)1.89835101
83Concave nail (HP:0001598)1.89733131
84Exercise intolerance (HP:0003546)1.86971456
85Synostosis of carpal bones (HP:0005048)1.84352087
86Hepatic necrosis (HP:0002605)1.82929204
87Hypoplasia of the radius (HP:0002984)1.82440912
88Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82331528
89Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82331528
90Congenital stationary night blindness (HP:0007642)1.81858265
91Sclerocornea (HP:0000647)1.81451858
92Dynein arm defect of respiratory motile cilia (HP:0012255)1.80453811
93Absent/shortened dynein arms (HP:0200106)1.80453811
94Horseshoe kidney (HP:0000085)1.79977749
95Septo-optic dysplasia (HP:0100842)1.79689808
96Abnormality of the renal cortex (HP:0011035)1.78583979
97Hypoplasia of the ulna (HP:0003022)1.75123221
98Polydipsia (HP:0001959)1.74753959
99Abnormal drinking behavior (HP:0030082)1.74753959
100Depressed nasal ridge (HP:0000457)1.74611235

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK33.93352522
2TXK3.19548608
3STK102.97227501
4WNK42.79346870
5MAP4K12.78827756
6CDK192.72823697
7MAP3K122.70685508
8MAP2K22.56105937
9MAP3K112.24213364
10DYRK22.23112430
11ADRBK22.10984737
12MAP4K22.05358179
13GRK11.94595834
14NME21.93364546
15MAP3K41.79998293
16MUSK1.74788930
17TNK21.73223901
18STK111.67951705
19TLK11.61947359
20WNK31.54254564
21PIM11.48640873
22ZAK1.42844228
23NEK91.42266734
24LRRK21.38277362
25STK161.37751359
26BCKDK1.34544492
27VRK21.30772885
28PIK3CA1.24116491
29FRK1.21410876
30DYRK1A1.20048993
31CAMKK21.19763847
32TEC1.17140574
33LIMK11.15353286
34ADRBK11.12726511
35TAOK31.12710657
36STK391.10429228
37PRKCQ1.09174697
38OXSR11.06899502
39PHKG21.06026454
40PHKG11.06026454
41BTK1.03095289
42NUAK11.02866463
43MKNK21.01242071
44EPHA40.97249234
45PRKCH0.93037617
46INSRR0.88203640
47RPS6KA60.85941943
48PRKCG0.84006147
49PINK10.79866716
50EPHB20.79609859
51TIE10.77816260
52PTK2B0.77039673
53OBSCN0.73138236
54DAPK30.73059217
55CAMKK10.73021674
56PLK40.72872839
57MAP2K10.72604622
58PASK0.72222617
59PRKACA0.71114485
60CAMK10.69549452
61VRK10.68164910
62ABL20.62161005
63BMPR1B0.61138049
64GRK70.59118277
65RPS6KA50.57918790
66PRKCZ0.57335773
67CDC70.57299888
68CSNK2A20.56914159
69PAK60.56228324
70RPS6KL10.55578959
71RPS6KC10.55578959
72MAPK130.55404195
73LCK0.53764619
74ERBB20.53485461
75RPS6KB20.53015717
76STK38L0.52751947
77EIF2AK10.52138902
78CSNK2A10.51592682
79KDR0.50766440
80MAP3K90.50499153
81SYK0.49770887
82GRK50.49675597
83NME10.48858700
84IKBKB0.48423560
85MINK10.44882865
86PRKCA0.44477630
87ITK0.44277219
88WNK10.42044000
89LYN0.41882415
90GRK60.41785911
91CASK0.41438497
92AURKA0.40767708
93CSNK1G20.40220046
94SGK2230.38482370
95SGK4940.38482370
96KIT0.38333120
97MAP2K40.37913610
98CAMK2A0.37870886
99LMTK20.36813809
100MAPK150.36331163

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.43343259
2Oxidative phosphorylation_Homo sapiens_hsa001903.81341518
3Asthma_Homo sapiens_hsa053103.32324541
4Parkinsons disease_Homo sapiens_hsa050123.20129046
5Graft-versus-host disease_Homo sapiens_hsa053322.67644610
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.61571151
7Allograft rejection_Homo sapiens_hsa053302.44063354
8Autoimmune thyroid disease_Homo sapiens_hsa053202.39623261
9Cardiac muscle contraction_Homo sapiens_hsa042602.38005589
10Phototransduction_Homo sapiens_hsa047442.37049010
11Alzheimers disease_Homo sapiens_hsa050102.27520103
12Huntingtons disease_Homo sapiens_hsa050162.24995365
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.10563066
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04972362
15Type I diabetes mellitus_Homo sapiens_hsa049401.98369457
16RNA polymerase_Homo sapiens_hsa030201.72567769
17Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.45043485
18Viral myocarditis_Homo sapiens_hsa054161.44497453
19Primary immunodeficiency_Homo sapiens_hsa053401.43757613
20Linoleic acid metabolism_Homo sapiens_hsa005911.43723848
21Proteasome_Homo sapiens_hsa030501.34398655
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32881482
23Homologous recombination_Homo sapiens_hsa034401.31148877
24RNA degradation_Homo sapiens_hsa030181.29174066
25Antigen processing and presentation_Homo sapiens_hsa046121.21564404
26Olfactory transduction_Homo sapiens_hsa047401.16127619
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12237586
28Sulfur relay system_Homo sapiens_hsa041221.07461897
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04519046
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01615101
31Basal transcription factors_Homo sapiens_hsa030221.01576294
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01066653
33Caffeine metabolism_Homo sapiens_hsa002320.99901085
34Rheumatoid arthritis_Homo sapiens_hsa053230.96758977
35Staphylococcus aureus infection_Homo sapiens_hsa051500.93514169
36Nicotine addiction_Homo sapiens_hsa050330.92361084
37Nucleotide excision repair_Homo sapiens_hsa034200.89789124
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86770730
39Protein export_Homo sapiens_hsa030600.86202750
40Pyrimidine metabolism_Homo sapiens_hsa002400.85118592
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82308507
42Nitrogen metabolism_Homo sapiens_hsa009100.81319717
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78295254
44Fat digestion and absorption_Homo sapiens_hsa049750.78018243
45Regulation of autophagy_Homo sapiens_hsa041400.73959699
46Arachidonic acid metabolism_Homo sapiens_hsa005900.72910372
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72417566
48Morphine addiction_Homo sapiens_hsa050320.71326558
49Hematopoietic cell lineage_Homo sapiens_hsa046400.70166735
50Mismatch repair_Homo sapiens_hsa034300.69706188
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69041990
52Systemic lupus erythematosus_Homo sapiens_hsa053220.68796718
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65801769
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64846741
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62741776
56Chemical carcinogenesis_Homo sapiens_hsa052040.62135160
57Fanconi anemia pathway_Homo sapiens_hsa034600.61963232
58Purine metabolism_Homo sapiens_hsa002300.61540660
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.58184413
60Retinol metabolism_Homo sapiens_hsa008300.57910875
61Leishmaniasis_Homo sapiens_hsa051400.57731096
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57557391
63Taste transduction_Homo sapiens_hsa047420.57041547
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56177646
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.55528650
66Basal cell carcinoma_Homo sapiens_hsa052170.55000480
67Peroxisome_Homo sapiens_hsa041460.52762333
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51872708
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49146250
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48870265
71Ether lipid metabolism_Homo sapiens_hsa005650.48770646
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44605833
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.44077140
74Salivary secretion_Homo sapiens_hsa049700.43381959
75p53 signaling pathway_Homo sapiens_hsa041150.43136209
76Base excision repair_Homo sapiens_hsa034100.42663283
77Hedgehog signaling pathway_Homo sapiens_hsa043400.42590853
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42475272
79Tryptophan metabolism_Homo sapiens_hsa003800.41918889
80Insulin secretion_Homo sapiens_hsa049110.40106233
81Collecting duct acid secretion_Homo sapiens_hsa049660.39418191
82Metabolic pathways_Homo sapiens_hsa011000.36850468
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.36810477
84beta-Alanine metabolism_Homo sapiens_hsa004100.33009306
85GABAergic synapse_Homo sapiens_hsa047270.32758291
86DNA replication_Homo sapiens_hsa030300.31453360
87Circadian entrainment_Homo sapiens_hsa047130.27937531
88Toxoplasmosis_Homo sapiens_hsa051450.26460713
89Propanoate metabolism_Homo sapiens_hsa006400.26311977
90Cholinergic synapse_Homo sapiens_hsa047250.26170151
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26055107
92Phagosome_Homo sapiens_hsa041450.21778183
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.19214642
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18954717
95Sulfur metabolism_Homo sapiens_hsa009200.17936910
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.17448859
97Mineral absorption_Homo sapiens_hsa049780.17101218
98Glutamatergic synapse_Homo sapiens_hsa047240.16702243
99Ovarian steroidogenesis_Homo sapiens_hsa049130.16137483
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15919464

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