ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	9.25953889
2	ribosomal small subunit assembly (GO:0000028)	7.64979729
3	viral transcription (GO:0019083)	7.25259459
4	translational termination (GO:0006415)	6.91952322
5	ATP synthesis coupled proton transport (GO:0015986)	5.87286196
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.87286196
7	translational elongation (GO:0006414)	5.79795120
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.73899596
9	cotranslational protein targeting to membrane (GO:0006613)	5.64822760
10	protein targeting to ER (GO:0045047)	5.64744390
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.41387013
12	protein localization to endoplasmic reticulum (GO:0070972)	5.35062733
13	viral life cycle (GO:0019058)	5.21242606
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.18482464
15	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.18166784
16	cellular protein complex disassembly (GO:0043624)	5.14074760
17	ribosomal large subunit biogenesis (GO:0042273)	4.61500410
18	nonmotile primary cilium assembly (GO:0035058)	4.60012647
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.58585539
20	translational initiation (GO:0006413)	4.40693844
21	protein complex disassembly (GO:0043241)	4.33081507
22	DNA deamination (GO:0045006)	4.24648727
23	behavioral response to nicotine (GO:0035095)	4.21800680
24	rRNA catabolic process (GO:0016075)	4.21576027
25	macromolecular complex disassembly (GO:0032984)	4.09456798
26	ribonucleoprotein complex biogenesis (GO:0022613)	3.96085086
27	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.81180066
28	positive regulation of fatty acid transport (GO:2000193)	3.78470058
29	protein targeting to membrane (GO:0006612)	3.75860119
30	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.72129649
31	electron transport chain (GO:0022900)	3.64830077
32	respiratory electron transport chain (GO:0022904)	3.63032527
33	mRNA catabolic process (GO:0006402)	3.62936638
34	positive regulation of prostaglandin secretion (GO:0032308)	3.57653961
35	translation (GO:0006412)	3.53972312
36	ATP biosynthetic process (GO:0006754)	3.49182898
37	positive regulation of respiratory burst (GO:0060267)	3.42401409
38	positive regulation of T cell apoptotic process (GO:0070234)	3.41336745
39	cellular component biogenesis (GO:0044085)	3.39588139
40	glycerophospholipid catabolic process (GO:0046475)	3.38726108
41	positive regulation of icosanoid secretion (GO:0032305)	3.37699422
42	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.29716505
43	RNA catabolic process (GO:0006401)	3.27176051
44	substrate-independent telencephalic tangential migration (GO:0021826)	3.24356621
45	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.24356621
46	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.23347978
47	auditory receptor cell differentiation (GO:0042491)	3.23188305
48	male meiosis I (GO:0007141)	3.15963437
49	tongue development (GO:0043586)	3.05326768
50	rRNA metabolic process (GO:0016072)	3.04751021
51	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.03478111
52	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.03478111
53	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.03262363
54	negative regulation of mast cell activation (GO:0033004)	3.02653854
55	ncRNA catabolic process (GO:0034661)	3.02091704
56	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.01284564
57	DNA damage response, detection of DNA damage (GO:0042769)	3.01228828
58	endoderm formation (GO:0001706)	2.97726958
59	indolalkylamine metabolic process (GO:0006586)	2.97661216
60	sulfation (GO:0051923)	2.97652833
61	rRNA processing (GO:0006364)	2.97392421
62	cell wall macromolecule catabolic process (GO:0016998)	2.96417201
63	myoblast migration (GO:0051451)	2.94845045
64	protein-cofactor linkage (GO:0018065)	2.92892175
65	L-fucose catabolic process (GO:0042355)	2.92235988
66	fucose catabolic process (GO:0019317)	2.92235988
67	L-fucose metabolic process (GO:0042354)	2.92235988
68	regulation of prostaglandin secretion (GO:0032306)	2.91500226
69	chaperone-mediated protein transport (GO:0072321)	2.88627608
70	regulation of action potential (GO:0098900)	2.88377204
71	somite development (GO:0061053)	2.87038165
72	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.85828662
73	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.84636665
74	sulfate transport (GO:0008272)	2.83071947
75	platelet dense granule organization (GO:0060155)	2.82645952
76	hydrogen ion transmembrane transport (GO:1902600)	2.82633500
77	adaptation of signaling pathway (GO:0023058)	2.81999735
78	protein complex biogenesis (GO:0070271)	2.81581529
79	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.77935626
80	piRNA metabolic process (GO:0034587)	2.76993194
81	regulation of posttranscriptional gene silencing (GO:0060147)	2.75657581
82	regulation of gene silencing by miRNA (GO:0060964)	2.75657581
83	regulation of gene silencing by RNA (GO:0060966)	2.75657581
84	glyoxylate metabolic process (GO:0046487)	2.73932344
85	ncRNA 3-end processing (GO:0043628)	2.72547727
86	sulfate transmembrane transport (GO:1902358)	2.72188083
87	negative regulation of telomere maintenance (GO:0032205)	2.69747063
88	GTP biosynthetic process (GO:0006183)	2.68072924
89	detection of light stimulus involved in visual perception (GO:0050908)	2.66904460
90	detection of light stimulus involved in sensory perception (GO:0050962)	2.66904460
91	DNA methylation involved in gamete generation (GO:0043046)	2.64432406
92	proton transport (GO:0015992)	2.63585205
93	protein neddylation (GO:0045116)	2.62818563
94	mitochondrial respiratory chain complex assembly (GO:0033108)	2.62509118
95	resolution of meiotic recombination intermediates (GO:0000712)	2.60379927
96	parturition (GO:0007567)	2.59906512
97	protein polyglutamylation (GO:0018095)	2.58790528
98	hydrogen transport (GO:0006818)	2.56509377
99	retinal rod cell development (GO:0046548)	2.55097923
100	maturation of SSU-rRNA (GO:0030490)	10.0447650

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.73937129
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.80841010
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.75988801
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.75026353
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.73995818
6	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.61414973
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.97635992
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.65631225
9	IRF1_19129219_ChIP-ChIP_H3396_Human	2.60197058
10	VDR_22108803_ChIP-Seq_LS180_Human	2.49896940
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.44820229
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.38032352
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.23612386
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.23383733
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.13442226
16	MYC_18940864_ChIP-ChIP_HL60_Human	2.07032060
17	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.91394423
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.78122805
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73778852
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.68415616
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.59446237
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.58390207
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50369557
24	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.48214826
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.44947732
26	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.42732068
27	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.39475041
28	NCOR_22424771_ChIP-Seq_293T_Human	1.37073997
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.34853891
30	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.34014857
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.33725017
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.31586903
33	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.30849438
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.30066920
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.29960759
36	NANOG_20526341_ChIP-Seq_ESCs_Human	1.29257083
37	TAF2_19829295_ChIP-Seq_ESCs_Human	1.27212539
38	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26108680
39	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.25756017
40	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.24147897
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21015113
42	ERA_21632823_ChIP-Seq_H3396_Human	1.20616948
43	CTCF_20526341_ChIP-Seq_ESCs_Human	1.18328871
44	CIITA_25753668_ChIP-Seq_RAJI_Human	1.17114193
45	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.15338376
46	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14564841
47	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.13932961
48	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13580769
49	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12613748
50	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.12258557
51	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.10717181
52	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.10225444
53	FUS_26573619_Chip-Seq_HEK293_Human	1.09160961
54	EWS_26573619_Chip-Seq_HEK293_Human	1.07073174
55	FOXP3_21729870_ChIP-Seq_TREG_Human	1.06601222
56	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06395367
57	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.06017770
58	IGF1R_20145208_ChIP-Seq_DFB_Human	1.05223379
59	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04963312
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02488186
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.02488186
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02463775
63	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02117512
64	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.02018513
65	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.01885995
66	REST_21632747_ChIP-Seq_MESCs_Mouse	1.01585740
67	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01538345
68	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01538345
69	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.01178606
70	RAC3_21632823_ChIP-Seq_H3396_Human	1.00458635
71	ER_23166858_ChIP-Seq_MCF-7_Human	1.00183046
72	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.99564284
73	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.99182203
74	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.98625009
75	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.98425232
76	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.97075400
77	ERG_20517297_ChIP-Seq_VCAP_Human	0.97052195
78	OCT4_20526341_ChIP-Seq_ESCs_Human	0.97043422
79	P300_19829295_ChIP-Seq_ESCs_Human	0.96872356
80	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.95081829
81	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.95037523
82	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.95032761
83	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.94137717
84	AR_20517297_ChIP-Seq_VCAP_Human	0.93049439
85	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.92746294
86	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.92630286
87	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.92046902
88	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.91594212
89	P53_21459846_ChIP-Seq_SAOS-2_Human	0.91355766
90	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.90713544
91	SOX2_19829295_ChIP-Seq_ESCs_Human	0.89631747
92	NANOG_19829295_ChIP-Seq_ESCs_Human	0.89631747
93	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.89254876
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.89001480
95	E2F1_20622854_ChIP-Seq_HELA_Human	0.88354401
96	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.87827171
97	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.86513589
98	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.85536973
99	BCL6_27268052_Chip-Seq_Bcells_Human	0.84355892
100	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.84097335

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.51098057
2	MP0008877_abnormal_DNA_methylation	3.70180813
3	MP0006292_abnormal_olfactory_placode	3.41241547
4	MP0003646_muscle_fatigue	3.28715112
5	MP0005083_abnormal_biliary_tract	2.84507844
6	MP0004145_abnormal_muscle_electrophysio	2.75327028
7	MP0005084_abnormal_gallbladder_morpholo	2.44249570
8	MP0001485_abnormal_pinna_reflex	2.43429840
9	MP0006276_abnormal_autonomic_nervous	2.38393891
10	MP0004742_abnormal_vestibular_system	2.33519804
11	MP0005360_urolithiasis	2.26628247
12	MP0008872_abnormal_physiological_respon	2.23915908
13	MP0003787_abnormal_imprinting	2.20156154
14	MP0003122_maternal_imprinting	2.12028738
15	MP0000569_abnormal_digit_pigmentation	2.11253574
16	MP0002138_abnormal_hepatobiliary_system	1.85840665
17	MP0004142_abnormal_muscle_tone	1.82096845
18	MP0002102_abnormal_ear_morphology	1.80440551
19	MP0005551_abnormal_eye_electrophysiolog	1.75885322
20	MP0002909_abnormal_adrenal_gland	1.73018199
21	MP0005174_abnormal_tail_pigmentation	1.70251800
22	MP0003195_calcinosis	1.65704622
23	MP0003121_genomic_imprinting	1.53965430
24	MP0006072_abnormal_retinal_apoptosis	1.51003980
25	MP0003938_abnormal_ear_development	1.48646794
26	MP0002653_abnormal_ependyma_morphology	1.38666726
27	MP0004043_abnormal_pH_regulation	1.36545588
28	MP0002184_abnormal_innervation	1.34531110
29	MP0008789_abnormal_olfactory_epithelium	1.32636541
30	MP0001293_anophthalmia	1.31002635
31	MP0004885_abnormal_endolymph	1.29206512
32	MP0008875_abnormal_xenobiotic_pharmacok	1.27515638
33	MP0003718_maternal_effect	1.26999844
34	MP0003183_abnormal_peptide_metabolism	1.25098590
35	MP0002736_abnormal_nociception_after	1.25014821
36	MP0005645_abnormal_hypothalamus_physiol	1.24484778
37	MP0001968_abnormal_touch/_nociception	1.21262652
38	MP0002234_abnormal_pharynx_morphology	1.20874517
39	MP0001440_abnormal_grooming_behavior	1.20338621
40	MP0000566_synostosis	1.19052471
41	MP0010386_abnormal_urinary_bladder	1.15749613
42	MP0002837_dystrophic_cardiac_calcinosis	1.14711718
43	MP0005394_taste/olfaction_phenotype	1.13933863
44	MP0005499_abnormal_olfactory_system	1.13933863
45	MP0000049_abnormal_middle_ear	1.13030022
46	MP0002095_abnormal_skin_pigmentation	1.12652450
47	MP0003880_abnormal_central_pattern	1.10405519
48	MP0005253_abnormal_eye_physiology	1.09123944
49	MP0003950_abnormal_plasma_membrane	1.09063320
50	MP0005195_abnormal_posterior_eye	1.09030436
51	MP0001502_abnormal_circadian_rhythm	1.08221450
52	MP0002733_abnormal_thermal_nociception	1.06544695
53	MP0004147_increased_porphyrin_level	1.05969092
54	MP0005365_abnormal_bile_salt	1.05498207
55	MP0001970_abnormal_pain_threshold	1.04621429
56	MP0002163_abnormal_gland_morphology	1.03768454
57	MP0000026_abnormal_inner_ear	1.02521680
58	MP0009745_abnormal_behavioral_response	1.02141051
59	MP0001963_abnormal_hearing_physiology	1.01364215
60	MP0004133_heterotaxia	1.01164001
61	MP0001905_abnormal_dopamine_level	0.99266439
62	MP0003937_abnormal_limbs/digits/tail_de	0.97133657
63	MP0002735_abnormal_chemical_nociception	0.94903551
64	MP0000230_abnormal_systemic_arterial	0.94886449
65	MP0005171_absent_coat_pigmentation	0.93904191
66	MP0000955_abnormal_spinal_cord	0.92050993
67	MP0002272_abnormal_nervous_system	0.90749376
68	MP0002557_abnormal_social/conspecific_i	0.86569796
69	MP0002752_abnormal_somatic_nervous	0.86304843
70	MP0002938_white_spotting	0.85769228
71	MP0000427_abnormal_hair_cycle	0.85038520
72	MP0001486_abnormal_startle_reflex	0.84998562
73	MP0000778_abnormal_nervous_system	0.81923676
74	MP0005085_abnormal_gallbladder_physiolo	0.81694710
75	MP0002229_neurodegeneration	0.79887533
76	MP0002876_abnormal_thyroid_physiology	0.79158096
77	MP0009250_abnormal_appendicular_skeleto	0.79127769
78	MP0000631_abnormal_neuroendocrine_gland	0.77583009
79	MP0001765_abnormal_ion_homeostasis	0.76810447
80	MP0002160_abnormal_reproductive_system	0.76664700
81	MP0004019_abnormal_vitamin_homeostasis	0.76478526
82	MP0002572_abnormal_emotion/affect_behav	0.76020812
83	MP0005389_reproductive_system_phenotype	0.75267815
84	MP0002063_abnormal_learning/memory/cond	0.74442624
85	MP0003186_abnormal_redox_activity	0.72887336
86	MP0003567_abnormal_fetal_cardiomyocyte	0.72724003
87	MP0005670_abnormal_white_adipose	0.72681546
88	MP0002064_seizures	0.71094850
89	MP0003698_abnormal_male_reproductive	0.70773367
90	MP0003635_abnormal_synaptic_transmissio	0.70772797
91	MP0005671_abnormal_response_to	0.70357997
92	MP0001324_abnormal_eye_pigmentation	0.69096740
93	MP0002067_abnormal_sensory_capabilities	0.68687651
94	MP0002928_abnormal_bile_duct	0.68627659
95	MP0008775_abnormal_heart_ventricle	0.66000311
96	MP0001764_abnormal_homeostasis	0.64625312
97	MP0001929_abnormal_gametogenesis	0.63857373
98	MP0002210_abnormal_sex_determination	0.62737092
99	MP0004134_abnormal_chest_morphology	0.62654421
100	MP0005636_abnormal_mineral_homeostasis	0.61349636

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.73454568
2	Molar tooth sign on MRI (HP:0002419)	5.43989824
3	Abnormality of midbrain morphology (HP:0002418)	5.43989824
4	Abnormality of cells of the erythroid lineage (HP:0012130)	4.56391222
5	Partial duplication of thumb phalanx (HP:0009944)	4.52046534
6	Stenosis of the external auditory canal (HP:0000402)	4.23100491
7	Colon cancer (HP:0003003)	4.09475076
8	Acute necrotizing encephalopathy (HP:0006965)	3.98832554
9	Partial duplication of the phalanx of hand (HP:0009999)	3.87382166
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.85593826
11	Acute encephalopathy (HP:0006846)	3.78205049
12	Hyperglycinemia (HP:0002154)	3.54709281
13	Pallor (HP:0000980)	3.20896895
14	Progressive macrocephaly (HP:0004481)	3.19474499
15	Macrocytic anemia (HP:0001972)	3.15771602
16	Chronic hepatic failure (HP:0100626)	3.14714072
17	Mitochondrial inheritance (HP:0001427)	3.13600661
18	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.10516422
19	Hypoplasia of the pons (HP:0012110)	3.08095839
20	Abnormal hemoglobin (HP:0011902)	2.97466464
21	Hypoplasia of the radius (HP:0002984)	2.96028251
22	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.92809772
23	Pancreatic cysts (HP:0001737)	2.88914308
24	Increased CSF lactate (HP:0002490)	2.85712745
25	Hepatocellular necrosis (HP:0001404)	2.78620614
26	Abnormal number of erythroid precursors (HP:0012131)	2.77564235
27	Abolished electroretinogram (ERG) (HP:0000550)	2.75144537
28	Abnormality of the pons (HP:0007361)	2.74200730
29	Abnormal drinking behavior (HP:0030082)	2.65685502
30	Polydipsia (HP:0001959)	2.65685502
31	Pancreatic fibrosis (HP:0100732)	2.64836905
32	Small hand (HP:0200055)	2.63582220
33	Polyphagia (HP:0002591)	2.60128262
34	Hyperventilation (HP:0002883)	2.60018360
35	Nephronophthisis (HP:0000090)	2.57584320
36	Hepatic necrosis (HP:0002605)	2.56103911
37	Methylmalonic acidemia (HP:0002912)	2.46922238
38	Pendular nystagmus (HP:0012043)	2.44053291
39	Absent thumb (HP:0009777)	2.38045521
40	Abnormal rod and cone electroretinograms (HP:0008323)	2.32770492
41	Cerebral edema (HP:0002181)	2.31855785
42	Methylmalonic aciduria (HP:0012120)	2.28131749
43	Chorioretinal atrophy (HP:0000533)	2.26400842
44	Anencephaly (HP:0002323)	2.24378061
45	Tetany (HP:0001281)	2.24117530
46	Abnormality of glycine metabolism (HP:0010895)	2.24099890
47	Abnormality of serine family amino acid metabolism (HP:0010894)	2.24099890
48	Attenuation of retinal blood vessels (HP:0007843)	2.23486165
49	True hermaphroditism (HP:0010459)	2.23373926
50	Tachypnea (HP:0002789)	2.21468419
51	Abnormality of the renal cortex (HP:0011035)	2.21221430
52	Congenital stationary night blindness (HP:0007642)	2.19783660
53	Increased serum lactate (HP:0002151)	2.18864610
54	Febrile seizures (HP:0002373)	2.18114523
55	Increased intramyocellular lipid droplets (HP:0012240)	2.12067098
56	Renal cortical cysts (HP:0000803)	2.11332764
57	Ependymoma (HP:0002888)	2.05912635
58	Hyperglycinuria (HP:0003108)	2.05287151
59	Forearm undergrowth (HP:0009821)	2.05212219
60	Abnormality of the renal medulla (HP:0100957)	1.99892870
61	Leukodystrophy (HP:0002415)	1.99382328
62	Bony spicule pigmentary retinopathy (HP:0007737)	1.98649999
63	Lethargy (HP:0001254)	1.98156332
64	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.97761531
65	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.97761531
66	Abnormal eating behavior (HP:0100738)	1.97490731
67	Hypoplasia of the ulna (HP:0003022)	1.96381270
68	Polyuria (HP:0000103)	1.95953646
69	Tubular atrophy (HP:0000092)	1.90150064
70	Hypomagnesemia (HP:0002917)	1.89359584
71	Lactic acidosis (HP:0003128)	1.89212327
72	Medial flaring of the eyebrow (HP:0010747)	1.88783667
73	Optic disc pallor (HP:0000543)	1.87789179
74	Duplication of thumb phalanx (HP:0009942)	1.87681428
75	Postaxial foot polydactyly (HP:0001830)	1.86946957
76	Depressed nasal ridge (HP:0000457)	1.83923309
77	Abnormality of the labia minora (HP:0012880)	1.83511665
78	Hyperthyroidism (HP:0000836)	1.79747372
79	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.79551754
80	Abnormality of alanine metabolism (HP:0010916)	1.79551754
81	Hyperalaninemia (HP:0003348)	1.79551754
82	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.77935052
83	Cerebellar dysplasia (HP:0007033)	1.76447272
84	Sclerocornea (HP:0000647)	1.72950055
85	Septo-optic dysplasia (HP:0100842)	1.72425031
86	Type II lissencephaly (HP:0007260)	1.70777429
87	11 pairs of ribs (HP:0000878)	1.69386427
88	Amelogenesis imperfecta (HP:0000705)	1.67785574
89	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.67546425
90	Papilledema (HP:0001085)	1.66473681
91	Abnormality of the parietal bone (HP:0002696)	1.66030545
92	Respiratory failure (HP:0002878)	1.65635806
93	Narrow forehead (HP:0000341)	1.64459263
94	Conical tooth (HP:0000698)	1.63959476
95	Absent septum pellucidum (HP:0001331)	1.63725042
96	Double outlet right ventricle (HP:0001719)	1.63191169
97	Congenital malformation of the right heart (HP:0011723)	1.63191169
98	Increased hepatocellular lipid droplets (HP:0006565)	1.61901408
99	Epileptic encephalopathy (HP:0200134)	1.60822691
100	Pachygyria (HP:0001302)	1.59953086

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	5.17753438
2	WNK4	4.62700507
3	STK39	3.43116885
4	INSRR	3.02425663
5	ADRBK2	3.00261539
6	LATS1	2.81113200
7	OXSR1	2.77422696
8	MUSK	2.59896302
9	NUAK1	2.55207359
10	VRK2	2.06959141
11	PINK1	2.03155947
12	GRK1	2.01547759
13	CAMKK2	1.93858182
14	MAP4K1	1.84177326
15	PDK2	1.79116882
16	BCKDK	1.78440897
17	PIK3CA	1.71776017
18	EPHB2	1.69579164
19	ZAK	1.58518880
20	TLK1	1.57077318
21	TRIM28	1.56760490
22	PAK3	1.44514977
23	LRRK2	1.42299384
24	MAP4K2	1.41099202
25	FRK	1.37041179
26	NEK1	1.31343280
27	MAP2K7	1.31108140
28	DYRK2	1.30152419
29	MAP3K4	1.29735641
30	PAK6	1.24146732
31	CAMK1	1.20760385
32	BMPR1B	1.19951588
33	CAMKK1	1.19843549
34	CHEK2	1.18129850
35	PRKCG	1.16060874
36	NME1	1.14770282
37	CDK19	1.12915200
38	NTRK2	1.03989520
39	ADRBK1	1.02089965
40	AURKA	1.01599634
41	STK3	1.00739791
42	PRKCI	0.93637947
43	TAOK3	0.92770749
44	STK16	0.88862444
45	TNIK	0.86726064
46	PRKCZ	0.84693859
47	CDC7	0.84224248
48	DYRK1B	0.81340980
49	VRK1	0.81238457
50	TAF1	0.77436049
51	TYRO3	0.76455598
52	WNK3	0.74693531
53	AKT3	0.72745636
54	NTRK1	0.70888556
55	IKBKB	0.68841736
56	NME2	0.65888801
57	CSNK2A2	0.62616063
58	STK11	0.61476357
59	PRKACA	0.60863618
60	DAPK3	0.60761755
61	TIE1	0.57617577
62	PTK2B	0.55258083
63	PRKCQ	0.53424061
64	CASK	0.52695255
65	PLK1	0.52182299
66	MAP2K2	0.50673527
67	MKNK2	0.43158800
68	OBSCN	0.40377108
69	CAMK2A	0.39480944
70	CAMK1D	0.39267306
71	ITK	0.39166448
72	CAMK4	0.38543469
73	CSNK1E	0.37851142
74	PLK2	0.37753243
75	LYN	0.37339211
76	PHKG2	0.37106192
77	PHKG1	0.37106192
78	PRKCA	0.34320809
79	MAPK13	0.34172112
80	DAPK1	0.32805205
81	PRKACG	0.32790818
82	GRK7	0.32788986
83	RPS6KA6	0.32360796
84	SYK	0.32189750
85	SGK223	0.32126912
86	SGK494	0.32126912
87	FES	0.31090507
88	BRSK1	0.30605196
89	PRKACB	0.30464635
90	PRKCH	0.30275731
91	PRKCD	0.30165002
92	EPHA4	0.29554873
93	CDK3	0.28454095
94	CSNK2A1	0.26726205
95	TGFBR1	0.26325547
96	PRKCE	0.25714682
97	SGK2	0.25297220
98	KIT	0.25228060
99	AURKB	0.24722022
100	PAK2	0.24714261

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.28966070
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.09637153
3	Parkinsons disease_Homo sapiens_hsa05012	3.20285488
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.55531812
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.55247423
6	Huntingtons disease_Homo sapiens_hsa05016	2.44451144
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.33207082
8	Alzheimers disease_Homo sapiens_hsa05010	2.25348458
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.23767461
10	Homologous recombination_Homo sapiens_hsa03440	2.22996974
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.96194097
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.90649115
13	Graft-versus-host disease_Homo sapiens_hsa05332	1.82446297
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.75618702
15	RNA degradation_Homo sapiens_hsa03018	1.74422465
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.67811642
17	Asthma_Homo sapiens_hsa05310	1.64469563
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.44322441
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.42693822
20	Phototransduction_Homo sapiens_hsa04744	1.37744891
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.37409427
22	Caffeine metabolism_Homo sapiens_hsa00232	1.37164551
23	RNA polymerase_Homo sapiens_hsa03020	1.36026466
24	Propanoate metabolism_Homo sapiens_hsa00640	1.35968698
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.32101186
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.31747458
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.27851928
28	Allograft rejection_Homo sapiens_hsa05330	1.25799820
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.25553917
30	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.25355445
31	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.24569635
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.22291563
33	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.21763144
34	Fat digestion and absorption_Homo sapiens_hsa04975	1.16953253
35	Type I diabetes mellitus_Homo sapiens_hsa04940	1.16878127
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.15544381
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.11696507
38	Proteasome_Homo sapiens_hsa03050	1.11521635
39	Peroxisome_Homo sapiens_hsa04146	1.08795954
40	beta-Alanine metabolism_Homo sapiens_hsa00410	1.06149384
41	Protein export_Homo sapiens_hsa03060	1.06046621
42	Butanoate metabolism_Homo sapiens_hsa00650	1.05248234
43	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.01748672
44	Base excision repair_Homo sapiens_hsa03410	1.01370214
45	Basal transcription factors_Homo sapiens_hsa03022	1.00563975
46	Olfactory transduction_Homo sapiens_hsa04740	0.97321388
47	Nicotine addiction_Homo sapiens_hsa05033	0.95891483
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.93960181
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.93213988
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.92988932
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91794837
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.90989964
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.89737358
54	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.88477202
55	One carbon pool by folate_Homo sapiens_hsa00670	0.88041551
56	Nucleotide excision repair_Homo sapiens_hsa03420	0.83359494
57	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.76476136
58	Metabolic pathways_Homo sapiens_hsa01100	0.73616052
59	Mismatch repair_Homo sapiens_hsa03430	0.72866587
60	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.70949446
61	Retinol metabolism_Homo sapiens_hsa00830	0.69450676
62	Fatty acid degradation_Homo sapiens_hsa00071	0.68415551
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68099516
64	Taste transduction_Homo sapiens_hsa04742	0.64901331
65	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.62888384
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.62322444
67	Steroid biosynthesis_Homo sapiens_hsa00100	0.61008647
68	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.60697920
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60624644
70	DNA replication_Homo sapiens_hsa03030	0.55132251
71	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.54718549
72	Morphine addiction_Homo sapiens_hsa05032	0.54216686
73	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.53906690
74	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.49629317
75	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.48667685
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48581387
77	Mineral absorption_Homo sapiens_hsa04978	0.48204999
78	Purine metabolism_Homo sapiens_hsa00230	0.46632325
79	Antigen processing and presentation_Homo sapiens_hsa04612	0.45907835
80	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.45518336
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.44459904
82	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.42106282
83	Sulfur metabolism_Homo sapiens_hsa00920	0.41906699
84	Rheumatoid arthritis_Homo sapiens_hsa05323	0.41724830
85	Serotonergic synapse_Homo sapiens_hsa04726	0.38904773
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.38882530
87	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38513966
88	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.38389166
89	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.38274492
90	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.38267622
91	Spliceosome_Homo sapiens_hsa03040	0.37395552
92	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.37055914
93	Glutathione metabolism_Homo sapiens_hsa00480	0.36985128
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.30882910
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.30285410
96	Non-homologous end-joining_Homo sapiens_hsa03450	0.29474130
97	Histidine metabolism_Homo sapiens_hsa00340	0.29349221
98	Hippo signaling pathway_Homo sapiens_hsa04390	0.29174326
99	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.27224840
100	Collecting duct acid secretion_Homo sapiens_hsa04966	0.26973253

RPL17P45

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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