ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of prostaglandin secretion (GO:0032306)	8.84311689
2	regulation of corticosteroid hormone secretion (GO:2000846)	8.69510656
3	viral transcription (GO:0019083)	6.96133469
4	positive regulation of icosanoid secretion (GO:0032305)	6.81142350
5	DNA deamination (GO:0045006)	6.77941585
6	translational termination (GO:0006415)	6.59702843
7	negative regulation of sterol transport (GO:0032372)	6.50793742
8	negative regulation of cholesterol transport (GO:0032375)	6.50793742
9	positive regulation of fatty acid transport (GO:2000193)	6.49501108
10	behavioral response to nicotine (GO:0035095)	6.46865303
11	regulation of steroid hormone secretion (GO:2000831)	6.34853687
12	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.16229423
13	regulation of appetite (GO:0032098)	5.97586680
14	translational elongation (GO:0006414)	5.86202199
15	phosphatidylinositol acyl-chain remodeling (GO:0036149)	5.83871069
16	phosphatidylserine acyl-chain remodeling (GO:0036150)	5.76782805
17	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.40167379
18	cotranslational protein targeting to membrane (GO:0006613)	5.31535835
19	regulation of icosanoid secretion (GO:0032303)	5.29890738
20	ribosomal small subunit assembly (GO:0000028)	5.25629514
21	positive regulation of macrophage derived foam cell differentiation (GO:0010744)	5.23928341
22	viral life cycle (GO:0019058)	5.23479667
23	ribosomal small subunit biogenesis (GO:0042274)	5.22092148
24	cellular protein complex disassembly (GO:0043624)	5.21836035
25	protein targeting to ER (GO:0045047)	5.20999551
26	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	5.09825097
27	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.99062124
28	protein localization to endoplasmic reticulum (GO:0070972)	4.84970335
29	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.84709951
30	locomotory exploration behavior (GO:0035641)	4.72345990
31	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.59858185
32	anterograde synaptic vesicle transport (GO:0048490)	4.49174477
33	protein complex disassembly (GO:0043241)	4.41323061
34	tyrosine phosphorylation of STAT protein (GO:0007260)	4.36763226
35	maturation of SSU-rRNA (GO:0030490)	4.32045201
36	positive regulation of protein sumoylation (GO:0033235)	4.31162168
37	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.19489439
38	positive regulation of lipid storage (GO:0010884)	4.14978764
39	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.08693388
40	ATP synthesis coupled proton transport (GO:0015986)	4.08693388
41	response to pheromone (GO:0019236)	4.08201700
42	macromolecular complex disassembly (GO:0032984)	3.99710104
43	inner ear receptor cell development (GO:0060119)	3.97175857
44	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.96937178
45	metallo-sulfur cluster assembly (GO:0031163)	3.96665636
46	iron-sulfur cluster assembly (GO:0016226)	3.96665636
47	positive regulation of organic acid transport (GO:0032892)	3.94145725
48	translational initiation (GO:0006413)	3.88294068
49	regulation of cholesterol efflux (GO:0010874)	3.84422593
50	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.78805083
51	positive regulation of cell fate commitment (GO:0010455)	3.70395397
52	response to misfolded protein (GO:0051788)	3.62425104
53	cytidine metabolic process (GO:0046087)	3.57975559
54	cytidine catabolic process (GO:0006216)	3.57975559
55	cytidine deamination (GO:0009972)	3.57975559
56	regulation of endocrine process (GO:0044060)	3.56523571
57	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.53365051
58	phosphatidylcholine acyl-chain remodeling (GO:0036151)	3.52279639
59	protein targeting to membrane (GO:0006612)	3.46463978
60	cysteine metabolic process (GO:0006534)	3.36755983
61	regulation of macrophage activation (GO:0043030)	3.30618102
62	signal complex assembly (GO:0007172)	3.30611728
63	pigmentation (GO:0043473)	3.26354482
64	protein neddylation (GO:0045116)	3.20950290
65	response to interferon-alpha (GO:0035455)	3.20687747
66	melanosome organization (GO:0032438)	3.12728248
67	ovulation cycle (GO:0042698)	3.06338991
68	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.05246673
69	positive regulation of hair cycle (GO:0042635)	3.04036794
70	positive regulation of hair follicle development (GO:0051798)	3.04036794
71	peptide hormone processing (GO:0016486)	3.03424532
72	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.97056919
73	phosphatidylserine metabolic process (GO:0006658)	2.93147966
74	regulation of fatty acid transport (GO:2000191)	2.92585917
75	viral protein processing (GO:0019082)	2.92170248
76	pigment granule organization (GO:0048753)	2.92006185
77	anterograde axon cargo transport (GO:0008089)	2.90382240
78	regulation of macrophage derived foam cell differentiation (GO:0010743)	2.89576163
79	reflex (GO:0060004)	2.88304275
80	mRNA catabolic process (GO:0006402)	2.87458761
81	immunoglobulin mediated immune response (GO:0016064)	2.84567697
82	apoptotic DNA fragmentation (GO:0006309)	2.83965309
83	lateral sprouting from an epithelium (GO:0060601)	2.83409747
84	regulation of lipid storage (GO:0010883)	2.80466313
85	exploration behavior (GO:0035640)	2.75808481
86	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.73272042
87	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.71015661
88	neuron fate determination (GO:0048664)	2.64849068
89	ribosomal large subunit biogenesis (GO:0042273)	2.62839845
90	regulation of protein sumoylation (GO:0033233)	2.61690562
91	auditory receptor cell differentiation (GO:0042491)	2.61576170
92	negative regulation of astrocyte differentiation (GO:0048712)	2.59074618
93	oligosaccharide biosynthetic process (GO:0009312)	2.59004074
94	middle ear morphogenesis (GO:0042474)	2.58534728
95	regulation of female gonad development (GO:2000194)	2.58373834
96	negative regulation of lipid transport (GO:0032369)	2.57394189
97	outer ear morphogenesis (GO:0042473)	2.56798426
98	translation (GO:0006412)	2.53871391
99	regulation of glucocorticoid secretion (GO:2000849)	10.4497945
100	positive regulation of prostaglandin secretion (GO:0032308)	10.2434171

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	6.77682055
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.39517301
3	EZH2_22144423_ChIP-Seq_EOC_Human	4.23116433
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.97227800
5	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.79813972
6	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.67722239
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.28896388
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.21930067
9	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.06006698
10	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.03530702
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.99263725
12	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.86478240
13	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.82763353
14	STAT1_20625510_ChIP-Seq_HELA_Human	1.75492096
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.74903897
16	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.71144821
17	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.69924902
18	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.69247533
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.67838843
20	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.62570155
21	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.60520861
22	TP53_22573176_ChIP-Seq_HFKS_Human	1.59988543
23	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.59841458
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59034794
25	VDR_22108803_ChIP-Seq_LS180_Human	1.56735471
26	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.49758785
27	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.48326326
28	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.48176667
29	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.47861483
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.46419045
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.44178298
32	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.42727758
33	REST_21632747_ChIP-Seq_MESCs_Mouse	1.42479633
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.42066956
35	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.40566040
36	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.38096574
37	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37711015
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37711015
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.37270561
40	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.37020792
41	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.36239199
42	FUS_26573619_Chip-Seq_HEK293_Human	1.35784617
43	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.35645684
44	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.34112066
45	NANOG_20526341_ChIP-Seq_ESCs_Human	1.32221291
46	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.31104379
47	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.30551945
48	RXR_22108803_ChIP-Seq_LS180_Human	1.29968054
49	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.29494002
50	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28882749
51	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.28772458
52	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.27144504
53	MYC_18940864_ChIP-ChIP_HL60_Human	1.26120346
54	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.25996412
55	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25302469
56	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.24877509
57	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.23853754
58	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.23845135
59	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.21474703
60	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.20699114
61	OCT4_20526341_ChIP-Seq_ESCs_Human	1.19582994
62	NCOR_22424771_ChIP-Seq_293T_Human	1.14800454
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13787151
64	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.12928715
65	TAF15_26573619_Chip-Seq_HEK293_Human	1.12464670
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11018283
67	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.10724543
68	RUNX_20019798_ChIP-Seq_JUKART_Human	1.09330974
69	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.08740586
70	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.08740586
71	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.08513431
72	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07628029
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06761043
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06761043
75	EWS_26573619_Chip-Seq_HEK293_Human	1.06133405
76	IGF1R_20145208_ChIP-Seq_DFB_Human	1.06035975
77	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.05721295
78	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.02240348
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01567891
80	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01361905
81	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.00896777
82	GBX2_23144817_ChIP-Seq_PC3_Human	1.00588021
83	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99949663
84	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99399757
85	AR_25329375_ChIP-Seq_VCAP_Human	0.99255584
86	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.97846588
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97538969
88	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96974329
89	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.95682155
90	AR_20517297_ChIP-Seq_VCAP_Human	0.94678757
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94248557
92	P300_19829295_ChIP-Seq_ESCs_Human	0.93532707
93	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.93248578
94	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.92912612
95	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.92763295
96	TP53_16413492_ChIP-PET_HCT116_Human	0.91033118
97	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.90640800
98	CTCF_20526341_ChIP-Seq_ESCs_Human	0.89311801
99	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.88923173
100	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.87934082

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	7.68837947
2	MP0009379_abnormal_foot_pigmentation	5.26624354
3	MP0002909_abnormal_adrenal_gland	3.88254510
4	MP0001968_abnormal_touch/_nociception	3.80378421
5	MP0009333_abnormal_splenocyte_physiolog	2.91564390
6	MP0001905_abnormal_dopamine_level	2.57735944
7	MP0005409_darkened_coat_color	2.49719547
8	MP0010386_abnormal_urinary_bladder	2.45100896
9	MP0005671_abnormal_response_to	2.32124118
10	MP0002638_abnormal_pupillary_reflex	2.31480117
11	MP0006054_spinal_hemorrhage	2.27138003
12	MP0005646_abnormal_pituitary_gland	2.24075545
13	MP0003879_abnormal_hair_cell	2.12835207
14	MP0004742_abnormal_vestibular_system	2.09903855
15	MP0001485_abnormal_pinna_reflex	2.09466622
16	MP0000343_altered_response_to	2.07112838
17	MP0001348_abnormal_lacrimal_gland	2.06577580
18	MP0000537_abnormal_urethra_morphology	1.99559105
19	MP0003279_aneurysm	1.95358534
20	MP0006292_abnormal_olfactory_placode	1.91520845
21	MP0004484_altered_response_of	1.86539681
22	MP0010030_abnormal_orbit_morphology	1.81343737
23	MP0000566_synostosis	1.80148184
24	MP0005377_hearing/vestibular/ear_phenot	1.71833797
25	MP0003878_abnormal_ear_physiology	1.71833797
26	MP0002254_reproductive_system_inflammat	1.60463809
27	MP0002938_white_spotting	1.60045803
28	MP0000049_abnormal_middle_ear	1.59849403
29	MP0003638_abnormal_response/metabolism_	1.54578257
30	MP0001346_abnormal_lacrimal_gland	1.43871781
31	MP0001963_abnormal_hearing_physiology	1.43704381
32	MP0000465_gastrointestinal_hemorrhage	1.43281871
33	MP0002139_abnormal_hepatobiliary_system	1.42153547
34	MP0000026_abnormal_inner_ear	1.40559974
35	MP0000613_abnormal_salivary_gland	1.40214273
36	MP0003315_abnormal_perineum_morphology	1.38707117
37	MP0002138_abnormal_hepatobiliary_system	1.38001308
38	MP0008995_early_reproductive_senescence	1.29165540
39	MP0000230_abnormal_systemic_arterial	1.28972789
40	MP0004885_abnormal_endolymph	1.23938516
41	MP0005085_abnormal_gallbladder_physiolo	1.23426360
42	MP0001873_stomach_inflammation	1.22166286
43	MP0000371_diluted_coat_color	1.21997043
44	MP0000639_abnormal_adrenal_gland	1.20769783
45	MP0004924_abnormal_behavior	1.15145394
46	MP0005386_behavior/neurological_phenoty	1.15145394
47	MP0000013_abnormal_adipose_tissue	1.14777115
48	MP0002282_abnormal_trachea_morphology	1.11713001
49	MP0005187_abnormal_penis_morphology	1.11370899
50	MP0000538_abnormal_urinary_bladder	1.10334707
51	MP0009745_abnormal_behavioral_response	1.10162106
52	MP0005448_abnormal_energy_balance	1.05927901
53	MP0006082_CNS_inflammation	1.04209680
54	MP0003195_calcinosis	1.03753058
55	MP0003938_abnormal_ear_development	1.02862229
56	MP0005083_abnormal_biliary_tract	1.00468047
57	MP0001440_abnormal_grooming_behavior	0.98174120
58	MP0008877_abnormal_DNA_methylation	0.97687548
59	MP0004142_abnormal_muscle_tone	0.95798734
60	MP0003880_abnormal_central_pattern	0.94760906
61	MP0009115_abnormal_fat_cell	0.93998887
62	MP0001835_abnormal_antigen_presentation	0.93217076
63	MP0008873_increased_physiological_sensi	0.93054115
64	MP0008872_abnormal_physiological_respon	0.92977252
65	MP0001800_abnormal_humoral_immune	0.89766798
66	MP0002557_abnormal_social/conspecific_i	0.89092051
67	MP0002249_abnormal_larynx_morphology	0.88165234
68	MP0002075_abnormal_coat/hair_pigmentati	0.87663012
69	MP0006072_abnormal_retinal_apoptosis	0.84980122
70	MP0009053_abnormal_anal_canal	0.83377142
71	MP0002723_abnormal_immune_serum	0.79085280
72	MP0002876_abnormal_thyroid_physiology	0.75544452
73	MP0009840_abnormal_foam_cell	0.75218659
74	MP0008789_abnormal_olfactory_epithelium	0.74489890
75	MP0002837_dystrophic_cardiac_calcinosis	0.74299801
76	MP0001765_abnormal_ion_homeostasis	0.69912489
77	MP0005423_abnormal_somatic_nervous	0.69840539
78	MP0003646_muscle_fatigue	0.69485710
79	MP0001845_abnormal_inflammatory_respons	0.68431941
80	MP0002272_abnormal_nervous_system	0.67649992
81	MP0008469_abnormal_protein_level	0.66635111
82	MP0005253_abnormal_eye_physiology	0.63573283
83	MP0003122_maternal_imprinting	0.63271839
84	MP0005623_abnormal_meninges_morphology	0.63203589
85	MP0005387_immune_system_phenotype	0.60433819
86	MP0001790_abnormal_immune_system	0.60433819
87	MP0005365_abnormal_bile_salt	0.59831684
88	MP0003123_paternal_imprinting	0.58832563
89	MP0000470_abnormal_stomach_morphology	0.58351181
90	MP0001529_abnormal_vocalization	0.58341026
91	MP0002405_respiratory_system_inflammati	0.56609264
92	MP0005551_abnormal_eye_electrophysiolog	0.54871221
93	MP0006276_abnormal_autonomic_nervous	0.54173349
94	MP0005389_reproductive_system_phenotype	0.52946115
95	MP0003252_abnormal_bile_duct	0.52023555
96	MP0010307_abnormal_tumor_latency	0.49345456
97	MP0002752_abnormal_somatic_nervous	0.47996352
98	MP0002184_abnormal_innervation	0.47748733
99	MP0002735_abnormal_chemical_nociception	0.47652399
100	MP0001186_pigmentation_phenotype	0.47609538

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Symptomatic seizures (HP:0011145)	8.82677757
2	Reduced antithrombin III activity (HP:0001976)	4.69712949
3	Hyperlipoproteinemia (HP:0010980)	4.54905097
4	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.70757154
5	Abnormal protein N-linked glycosylation (HP:0012347)	3.70757154
6	Abnormal protein glycosylation (HP:0012346)	3.70757154
7	Abnormal glycosylation (HP:0012345)	3.70757154
8	Stenosis of the external auditory canal (HP:0000402)	3.52446332
9	Xanthomatosis (HP:0000991)	3.30218831
10	Asplenia (HP:0001746)	3.16115249
11	Abnormality of cells of the erythroid lineage (HP:0012130)	3.15281534
12	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.95507450
13	B lymphocytopenia (HP:0010976)	2.94054162
14	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.89877776
15	Short chin (HP:0000331)	2.88636127
16	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.87117061
17	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.87117061
18	Macrocytic anemia (HP:0001972)	2.80216156
19	Abnormality of B cell number (HP:0010975)	2.76358650
20	Abnormal number of erythroid precursors (HP:0012131)	2.71782845
21	Elevated erythrocyte sedimentation rate (HP:0003565)	2.71129168
22	Thoracolumbar scoliosis (HP:0002944)	2.70915412
23	Hypoplasia of the pons (HP:0012110)	2.67913988
24	Pallor (HP:0000980)	2.64749861
25	Abnormality of the intrinsic pathway (HP:0010989)	2.63198780
26	Decreased circulating renin level (HP:0003351)	2.58307477
27	Abnormality of the pons (HP:0007361)	2.50823348
28	Facial hemangioma (HP:0000329)	2.49926647
29	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.49906898
30	Hypomagnesemia (HP:0002917)	2.47376953
31	Congenital sensorineural hearing impairment (HP:0008527)	2.43887952
32	Abnormality of the columella (HP:0009929)	2.42943281
33	Polydipsia (HP:0001959)	2.42170298
34	Abnormal drinking behavior (HP:0030082)	2.42170298
35	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.40419066
36	IgG deficiency (HP:0004315)	2.37479488
37	Reticulocytopenia (HP:0001896)	2.36690828
38	Limb dystonia (HP:0002451)	2.36441167
39	Polyuria (HP:0000103)	2.30698418
40	Chronic mucocutaneous candidiasis (HP:0002728)	2.29077572
41	Recurrent cutaneous fungal infections (HP:0011370)	2.29077572
42	Molar tooth sign on MRI (HP:0002419)	2.23664792
43	Abnormality of midbrain morphology (HP:0002418)	2.23664792
44	Partial duplication of the phalanx of hand (HP:0009999)	2.23577010
45	Bony spicule pigmentary retinopathy (HP:0007737)	2.23551631
46	Hyperinsulinemic hypoglycemia (HP:0000825)	2.23359287
47	Abnormal rod and cone electroretinograms (HP:0008323)	2.16129633
48	Abolished electroretinogram (ERG) (HP:0000550)	2.15536239
49	Partial duplication of thumb phalanx (HP:0009944)	2.14717152
50	Abnormal albumin level (HP:0012116)	2.14046575
51	Hypoalbuminemia (HP:0003073)	2.14046575
52	Abnormality of the middle phalanges of the toes (HP:0010183)	2.13495541
53	Parakeratosis (HP:0001036)	2.13424793
54	Stomach cancer (HP:0012126)	2.10101081
55	Type I transferrin isoform profile (HP:0003642)	2.08118018
56	Fused cervical vertebrae (HP:0002949)	2.06557867
57	Peritonitis (HP:0002586)	2.03562314
58	Abnormality of magnesium homeostasis (HP:0004921)	2.01520275
59	Hypoglycemic seizures (HP:0002173)	11.5341392
60	Septo-optic dysplasia (HP:0100842)	1.99999857
61	11 pairs of ribs (HP:0000878)	1.96675530
62	Abnormal urine output (HP:0012590)	1.93427033
63	Potter facies (HP:0002009)	1.91334768
64	Facial shape deformation (HP:0011334)	1.91334768
65	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.89368336
66	Bile duct proliferation (HP:0001408)	1.88341930
67	Abnormal biliary tract physiology (HP:0012439)	1.88341930
68	Hyperaldosteronism (HP:0000859)	1.84621756
69	Gastrointestinal infarctions (HP:0005244)	1.84348545
70	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.84189826
71	Synostosis involving the elbow (HP:0003938)	1.82766770
72	Humeroradial synostosis (HP:0003041)	1.82766770
73	Pendular nystagmus (HP:0012043)	1.82208221
74	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.82023404
75	Short tibia (HP:0005736)	1.79643851
76	Type 2 muscle fiber atrophy (HP:0003554)	1.78205077
77	Increased IgM level (HP:0003496)	1.77500306
78	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.76277586
79	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.76142224
80	Acute necrotizing encephalopathy (HP:0006965)	1.74110066
81	Absent septum pellucidum (HP:0001331)	1.73817349
82	Orchitis (HP:0100796)	1.73199397
83	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.72386995
84	Cutaneous finger syndactyly (HP:0010554)	1.70559233
85	Attenuation of retinal blood vessels (HP:0007843)	1.70358553
86	Thin ribs (HP:0000883)	1.69356844
87	Fragile nails (HP:0001808)	1.68970653
88	Bifid tongue (HP:0010297)	1.68696351
89	Abnormality of renal excretion (HP:0011036)	1.68412682
90	Hepatocellular necrosis (HP:0001404)	1.67592411
91	Vitreoretinal degeneration (HP:0000655)	1.66570959
92	Hypothermia (HP:0002045)	1.64911315
93	Rectal fistula (HP:0100590)	1.64098366
94	Rectovaginal fistula (HP:0000143)	1.64098366
95	Abnormality of renin-angiotensin system (HP:0000847)	1.63502668
96	Protruding tongue (HP:0010808)	1.63351636
97	Short hallux (HP:0010109)	1.62861846
98	Erythroderma (HP:0001019)	1.62623008
99	Generalized hypotonia (HP:0001290)	1.62157453
100	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.61923734

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	6.88400374
2	BCKDK	4.84961977
3	ADRBK2	4.19704428
4	NTRK3	3.82006611
5	GRK6	3.12954025
6	PRKD2	3.09395845
7	WNK4	2.69864731
8	ABL2	2.53361034
9	STK39	2.40933726
10	KIT	2.19041773
11	PTK6	2.14094593
12	ERBB2	1.98516271
13	TEC	1.90755967
14	CLK1	1.85558877
15	FGFR2	1.79360332
16	ZAK	1.77397974
17	TIE1	1.66391662
18	KDR	1.66343770
19	GRK1	1.65358616
20	TESK2	1.45419929
21	WNK3	1.40267895
22	ADRBK1	1.36621614
23	FRK	1.33928026
24	ERN1	1.29166904
25	LYN	1.25811796
26	BRSK2	1.05302847
27	IKBKE	1.02387304
28	SGK3	0.94151921
29	PINK1	0.91614874
30	EPHB2	0.91205799
31	INSRR	0.87460933
32	MAP4K1	0.82216570
33	DYRK1A	0.79217192
34	MAPK13	0.79177991
35	OXSR1	0.78590464
36	TXK	0.78513757
37	CASK	0.77046632
38	RPS6KA5	0.75463059
39	OBSCN	0.75013487
40	TBK1	0.72695359
41	NEK1	0.72301761
42	BUB1	0.72108534
43	AURKB	0.71388692
44	PHKG2	0.68135537
45	PHKG1	0.68135537
46	PRKCG	0.68128276
47	MAP3K9	0.67770291
48	MKNK2	0.67148455
49	MAP3K4	0.65536647
50	DYRK2	0.64167391
51	SYK	0.62626228
52	WEE1	0.61036413
53	ITK	0.60606130
54	LIMK1	0.58305858
55	CSF1R	0.57062033
56	LCK	0.56709382
57	MKNK1	0.55358114
58	PIK3CA	0.54073979
59	PRKD1	0.53476421
60	PRKACA	0.53361399
61	BTK	0.52910217
62	STK16	0.52767626
63	PLK4	0.51354544
64	EGFR	0.51092621
65	MUSK	0.50425958
66	PIM1	0.49160505
67	EPHA4	0.48529785
68	PKN1	0.44087294
69	NTRK2	0.43979416
70	TESK1	0.42935166
71	MAP4K2	0.42640323
72	PRKCD	0.42617431
73	FYN	0.40882349
74	HCK	0.40467112
75	LMTK2	0.40081997
76	PRKCA	0.39906138
77	MAP2K7	0.39526947
78	ARAF	0.38991464
79	NEK2	0.38155367
80	CSNK2A2	0.37589462
81	PRKCI	0.37202331
82	MYLK	0.37131813
83	PTK2B	0.37096597
84	PLK2	0.36473225
85	MAPK15	0.36079880
86	MAP2K6	0.36068165
87	VRK1	0.35659398
88	LRRK2	0.34782286
89	INSR	0.34014199
90	GRK7	0.33982084
91	DAPK3	0.33750684
92	MST4	0.33621309
93	PDPK1	0.33445165
94	TGFBR1	0.32758265
95	PRKCQ	0.32018322
96	PRKG1	0.31386401
97	PRKACB	0.30931954
98	FER	0.30724411
99	ABL1	0.29634637
100	TAOK3	0.28500196

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.52734048
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.04082016
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.00467994
4	Sulfur relay system_Homo sapiens_hsa04122	3.30045293
5	Graft-versus-host disease_Homo sapiens_hsa05332	2.97801334
6	Allograft rejection_Homo sapiens_hsa05330	2.96052413
7	Asthma_Homo sapiens_hsa05310	2.95935672
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.92118005
9	Fat digestion and absorption_Homo sapiens_hsa04975	2.71313723
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.49965709
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.28734008
12	Ether lipid metabolism_Homo sapiens_hsa00565	1.91887053
13	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.90261287
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.75011235
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.63373323
16	Regulation of autophagy_Homo sapiens_hsa04140	1.52459060
17	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.50687082
18	Parkinsons disease_Homo sapiens_hsa05012	1.49347977
19	Nicotine addiction_Homo sapiens_hsa05033	1.45493127
20	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.43051457
21	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.36446170
22	Antigen processing and presentation_Homo sapiens_hsa04612	1.35822397
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.35797572
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.35612360
25	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.30793456
26	Rheumatoid arthritis_Homo sapiens_hsa05323	1.27435808
27	Proteasome_Homo sapiens_hsa03050	1.26113346
28	Viral myocarditis_Homo sapiens_hsa05416	1.26054120
29	RNA polymerase_Homo sapiens_hsa03020	1.17035510
30	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.13274268
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.10176337
32	Mismatch repair_Homo sapiens_hsa03430	1.09809193
33	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.08738795
34	Huntingtons disease_Homo sapiens_hsa05016	1.03020953
35	Alzheimers disease_Homo sapiens_hsa05010	1.02700778
36	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.01504837
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.94807408
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.93579695
39	Butanoate metabolism_Homo sapiens_hsa00650	0.90936237
40	Nucleotide excision repair_Homo sapiens_hsa03420	0.89727386
41	Leishmaniasis_Homo sapiens_hsa05140	0.89159588
42	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88950661
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86902453
44	Pancreatic secretion_Homo sapiens_hsa04972	0.85185878
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83138896
46	Melanogenesis_Homo sapiens_hsa04916	0.77312542
47	Caffeine metabolism_Homo sapiens_hsa00232	0.76346180
48	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.75958772
49	Olfactory transduction_Homo sapiens_hsa04740	0.74995088
50	Malaria_Homo sapiens_hsa05144	0.68933502
51	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.68642657
52	DNA replication_Homo sapiens_hsa03030	0.68554806
53	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.68452586
54	Retinol metabolism_Homo sapiens_hsa00830	0.67508372
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66097144
56	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.60467473
57	Phototransduction_Homo sapiens_hsa04744	0.58549438
58	ABC transporters_Homo sapiens_hsa02010	0.53682636
59	RNA degradation_Homo sapiens_hsa03018	0.52633347
60	Tyrosine metabolism_Homo sapiens_hsa00350	0.52552132
61	Morphine addiction_Homo sapiens_hsa05032	0.52406897
62	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50302170
63	Insulin secretion_Homo sapiens_hsa04911	0.50145693
64	Fanconi anemia pathway_Homo sapiens_hsa03460	0.44295216
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.43254079
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43223913
67	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.43196737
68	Calcium signaling pathway_Homo sapiens_hsa04020	0.42828340
69	Purine metabolism_Homo sapiens_hsa00230	0.42686256
70	Sphingolipid metabolism_Homo sapiens_hsa00600	0.42657628
71	Alcoholism_Homo sapiens_hsa05034	0.42071836
72	Tuberculosis_Homo sapiens_hsa05152	0.41731921
73	Homologous recombination_Homo sapiens_hsa03440	0.41384411
74	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.38401383
75	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.38054948
76	Circadian entrainment_Homo sapiens_hsa04713	0.34179201
77	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.33383990
78	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.32132719
79	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.31539152
80	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.30629692
81	Taste transduction_Homo sapiens_hsa04742	0.30567585
82	Bile secretion_Homo sapiens_hsa04976	0.29885352
83	African trypanosomiasis_Homo sapiens_hsa05143	0.29019905
84	Salivary secretion_Homo sapiens_hsa04970	0.27926432
85	Peroxisome_Homo sapiens_hsa04146	0.27806688
86	Basal cell carcinoma_Homo sapiens_hsa05217	0.25183282
87	Amphetamine addiction_Homo sapiens_hsa05031	0.24825204
88	Ras signaling pathway_Homo sapiens_hsa04014	0.24665753
89	Metabolic pathways_Homo sapiens_hsa01100	0.23075928
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.21511853
91	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.21198177
92	Toxoplasmosis_Homo sapiens_hsa05145	0.20518983
93	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.18912518
94	Pyrimidine metabolism_Homo sapiens_hsa00240	0.18908570
95	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.18710907
96	Axon guidance_Homo sapiens_hsa04360	0.18147779
97	Pertussis_Homo sapiens_hsa05133	0.16586722
98	Propanoate metabolism_Homo sapiens_hsa00640	0.13243553
99	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.13219284
100	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.13087162

RPL17P49

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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