RPL17P50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)4.90389331
2protein localization to cilium (GO:0061512)4.62733481
3protein deneddylation (GO:0000338)4.41086698
4platelet dense granule organization (GO:0060155)4.20194894
5protein complex biogenesis (GO:0070271)4.10023124
6behavioral response to nicotine (GO:0035095)4.01496153
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96074540
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.95171241
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.83136920
10ATP synthesis coupled proton transport (GO:0015986)3.75971244
11energy coupled proton transport, down electrochemical gradient (GO:0015985)3.75971244
12epithelial cilium movement (GO:0003351)3.72302310
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.72156771
14mitochondrial respiratory chain complex I assembly (GO:0032981)3.72156771
15NADH dehydrogenase complex assembly (GO:0010257)3.72156771
16mitochondrial respiratory chain complex assembly (GO:0033108)3.63409769
17water-soluble vitamin biosynthetic process (GO:0042364)3.61206499
18DNA double-strand break processing (GO:0000729)3.55349429
19pyrimidine nucleobase catabolic process (GO:0006208)3.51727454
20response to pheromone (GO:0019236)3.45175389
21intraciliary transport (GO:0042073)3.42849889
22magnesium ion transport (GO:0015693)3.41055841
23neural tube formation (GO:0001841)3.35793150
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.33796414
25protein-cofactor linkage (GO:0018065)3.30535502
26electron transport chain (GO:0022900)3.29631030
27respiratory electron transport chain (GO:0022904)3.28984000
28proteasome assembly (GO:0043248)3.26743613
29nonmotile primary cilium assembly (GO:0035058)3.23038985
30C4-dicarboxylate transport (GO:0015740)3.22860746
31DNA integration (GO:0015074)3.17193713
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16857908
33exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11804821
34protein neddylation (GO:0045116)3.08306987
35cytochrome complex assembly (GO:0017004)3.07322400
36mannosylation (GO:0097502)3.04255777
37positive regulation of mitochondrial fission (GO:0090141)3.01833992
38nucleobase catabolic process (GO:0046113)3.00864020
39axoneme assembly (GO:0035082)2.99437702
40positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.94778967
41mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.94778967
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.93979304
43GPI anchor metabolic process (GO:0006505)2.92157308
44respiratory chain complex IV assembly (GO:0008535)2.89299584
45termination of RNA polymerase III transcription (GO:0006386)2.88996594
46transcription elongation from RNA polymerase III promoter (GO:0006385)2.88996594
47limb bud formation (GO:0060174)2.86333865
48DNA deamination (GO:0045006)2.84555202
49somite development (GO:0061053)2.83576922
50preassembly of GPI anchor in ER membrane (GO:0016254)2.81148323
51cilium movement (GO:0003341)2.79768262
52cilium morphogenesis (GO:0060271)2.79061247
53fucose catabolic process (GO:0019317)2.76768760
54L-fucose metabolic process (GO:0042354)2.76768760
55L-fucose catabolic process (GO:0042355)2.76768760
56cornea development in camera-type eye (GO:0061303)2.74576261
57hydrogen ion transmembrane transport (GO:1902600)2.73461170
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.72692393
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.72692393
60S-adenosylmethionine metabolic process (GO:0046500)2.72477535
61negative regulation of transcription regulatory region DNA binding (GO:2000678)2.71470860
62cilium organization (GO:0044782)2.70153620
63detection of light stimulus involved in sensory perception (GO:0050962)2.68098496
64detection of light stimulus involved in visual perception (GO:0050908)2.68098496
65proton transport (GO:0015992)2.67712245
66chaperone-mediated protein transport (GO:0072321)2.67380909
67neuronal action potential propagation (GO:0019227)2.67136410
68regulation of cilium movement (GO:0003352)2.66925811
69cilium assembly (GO:0042384)2.66917334
70negative regulation of mast cell activation (GO:0033004)2.66717595
71hydrogen transport (GO:0006818)2.66206546
72indolalkylamine metabolic process (GO:0006586)2.66107134
73retinal ganglion cell axon guidance (GO:0031290)2.65839636
74gamma-aminobutyric acid transport (GO:0015812)2.58609809
75regulation of mitochondrial translation (GO:0070129)2.57599604
76kidney morphogenesis (GO:0060993)2.56557984
77negative regulation of heart rate (GO:0010459)2.54816739
78ubiquinone metabolic process (GO:0006743)2.53501820
79ubiquinone biosynthetic process (GO:0006744)2.52833984
80regulation of feeding behavior (GO:0060259)2.50961936
81neuron fate determination (GO:0048664)2.49765906
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47920948
83centriole replication (GO:0007099)2.47132863
84GPI anchor biosynthetic process (GO:0006506)2.44949208
85photoreceptor cell maintenance (GO:0045494)2.44920308
86intracellular protein transmembrane import (GO:0044743)2.43584202
87glycosphingolipid biosynthetic process (GO:0006688)2.43201261
88anterograde synaptic vesicle transport (GO:0048490)2.42984054
89behavioral response to ethanol (GO:0048149)2.42591436
90L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.42033881
91aldehyde catabolic process (GO:0046185)2.41896548
92synaptic transmission, cholinergic (GO:0007271)2.41593801
93negative regulation of telomere maintenance (GO:0032205)2.40857560
94peptidyl-histidine modification (GO:0018202)2.40711959
95positive regulation of prostaglandin secretion (GO:0032308)2.40435346
96embryonic epithelial tube formation (GO:0001838)2.39307832
97primary amino compound metabolic process (GO:1901160)2.38933106
98transmission of nerve impulse (GO:0019226)2.38832666
99glycolipid biosynthetic process (GO:0009247)2.38737795
100organelle disassembly (GO:1903008)2.37535705

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.53802150
2IGF1R_20145208_ChIP-Seq_DFB_Human3.03253799
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97110316
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.96744466
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71571501
6VDR_22108803_ChIP-Seq_LS180_Human2.70423645
7GBX2_23144817_ChIP-Seq_PC3_Human2.69479732
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.60317682
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.57144985
10EZH2_22144423_ChIP-Seq_EOC_Human2.51612884
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50962841
12EWS_26573619_Chip-Seq_HEK293_Human2.43246003
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.30208103
14FUS_26573619_Chip-Seq_HEK293_Human2.22345174
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14266805
16TAF15_26573619_Chip-Seq_HEK293_Human2.10463957
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.10227364
18P300_19829295_ChIP-Seq_ESCs_Human2.08147305
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98018575
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.97270511
21ELK1_19687146_ChIP-ChIP_HELA_Human1.96047865
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91317788
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88245743
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74494731
25MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.64550597
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63621705
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62325198
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62304940
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.59926970
30VDR_23849224_ChIP-Seq_CD4+_Human1.59535783
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56029232
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54225310
33ER_23166858_ChIP-Seq_MCF-7_Human1.53436802
34IRF1_19129219_ChIP-ChIP_H3396_Human1.52485405
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.50394476
36MYC_18940864_ChIP-ChIP_HL60_Human1.49250741
37GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.48884364
38TP53_22573176_ChIP-Seq_HFKS_Human1.47799753
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46462872
40CBP_20019798_ChIP-Seq_JUKART_Human1.46462872
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46418221
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46196274
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39793654
44RNF2_27304074_Chip-Seq_NSC_Mouse1.39076108
45SOX2_19829295_ChIP-Seq_ESCs_Human1.38948685
46NANOG_19829295_ChIP-Seq_ESCs_Human1.38948685
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38287932
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.37786344
49KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36625822
50BCAT_22108803_ChIP-Seq_LS180_Human1.35617697
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.35308078
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.34392972
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34392972
54AR_25329375_ChIP-Seq_VCAP_Human1.32825831
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.32525587
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29394084
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28499851
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26830654
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25897539
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.23951766
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23826473
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22239766
63TCF4_22108803_ChIP-Seq_LS180_Human1.21650301
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.21275278
65FOXP3_21729870_ChIP-Seq_TREG_Human1.20756518
66SMAD4_21799915_ChIP-Seq_A2780_Human1.19729559
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19222896
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19023233
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17832140
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17115348
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17107211
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16851761
73STAT3_23295773_ChIP-Seq_U87_Human1.16208063
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16181583
75AR_20517297_ChIP-Seq_VCAP_Human1.14398434
76TCF4_23295773_ChIP-Seq_U87_Human1.11893237
77NCOR_22424771_ChIP-Seq_293T_Human1.11469254
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11429989
79RUNX2_22187159_ChIP-Seq_PCA_Human1.11268457
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10146808
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.09769566
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.08248695
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08114801
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05670237
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.05606689
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04634514
87GATA3_21878914_ChIP-Seq_MCF-7_Human1.04539657
88CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04457048
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04302790
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03656678
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03462853
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03279151
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03217806
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02726654
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01350198
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01122455
97CRX_20693478_ChIP-Seq_RETINA_Mouse1.00697351
98HTT_18923047_ChIP-ChIP_STHdh_Human1.00304651
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00044113
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99415381

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.20839713
2MP0006292_abnormal_olfactory_placode2.79102696
3MP0006072_abnormal_retinal_apoptosis2.75473997
4MP0002102_abnormal_ear_morphology2.68005263
5MP0003195_calcinosis2.64816107
6MP0008877_abnormal_DNA_methylation2.53553220
7MP0004147_increased_porphyrin_level2.40050880
8MP0003122_maternal_imprinting2.35035048
9MP0005551_abnormal_eye_electrophysiolog2.16240055
10MP0002837_dystrophic_cardiac_calcinosis2.12422690
11MP0005084_abnormal_gallbladder_morpholo2.11932516
12MP0003787_abnormal_imprinting2.11113441
13MP0005253_abnormal_eye_physiology2.02368048
14MP0002876_abnormal_thyroid_physiology1.98525742
15MP0001968_abnormal_touch/_nociception1.96102946
16MP0002736_abnormal_nociception_after1.94558017
17MP0001529_abnormal_vocalization1.91476658
18MP0006276_abnormal_autonomic_nervous1.86186554
19MP0004133_heterotaxia1.86060056
20MP0005646_abnormal_pituitary_gland1.85577900
21MP0004142_abnormal_muscle_tone1.79903704
22MP0002938_white_spotting1.71235647
23MP0001984_abnormal_olfaction1.70917916
24MP0003121_genomic_imprinting1.68950918
25MP0000631_abnormal_neuroendocrine_gland1.68112894
26MP0005645_abnormal_hypothalamus_physiol1.66553616
27MP0003011_delayed_dark_adaptation1.63588001
28MP0008872_abnormal_physiological_respon1.62429903
29MP0010386_abnormal_urinary_bladder1.58600314
30MP0009046_muscle_twitch1.57034597
31MP0003646_muscle_fatigue1.56064367
32MP0002272_abnormal_nervous_system1.55130379
33MP0002234_abnormal_pharynx_morphology1.54651987
34MP0009745_abnormal_behavioral_response1.49654737
35MP0002751_abnormal_autonomic_nervous1.47015472
36MP0001486_abnormal_startle_reflex1.43257256
37MP0008995_early_reproductive_senescence1.41861074
38MP0008875_abnormal_xenobiotic_pharmacok1.40693031
39MP0005367_renal/urinary_system_phenotyp1.40685458
40MP0000516_abnormal_urinary_system1.40685458
41MP0002638_abnormal_pupillary_reflex1.39227826
42MP0001986_abnormal_taste_sensitivity1.38462358
43MP0003136_yellow_coat_color1.37604393
44MP0001293_anophthalmia1.32296509
45MP0001764_abnormal_homeostasis1.31799669
46MP0002557_abnormal_social/conspecific_i1.30366241
47MP0002160_abnormal_reproductive_system1.25779193
48MP0008789_abnormal_olfactory_epithelium1.24990867
49MP0005389_reproductive_system_phenotype1.21417091
50MP0003718_maternal_effect1.15960181
51MP0002822_catalepsy1.12629337
52MP0000427_abnormal_hair_cycle1.11569641
53MP0001970_abnormal_pain_threshold1.09141908
54MP0001905_abnormal_dopamine_level1.09137772
55MP0005195_abnormal_posterior_eye1.08185329
56MP0002735_abnormal_chemical_nociception1.07389207
57MP0002572_abnormal_emotion/affect_behav1.06973609
58MP0004215_abnormal_myocardial_fiber1.06822003
59MP0000778_abnormal_nervous_system1.05441523
60MP0004019_abnormal_vitamin_homeostasis1.04249794
61MP0001919_abnormal_reproductive_system1.04032738
62MP0004885_abnormal_endolymph1.02816036
63MP0002184_abnormal_innervation1.02285041
64MP0006035_abnormal_mitochondrial_morpho1.02110900
65MP0002653_abnormal_ependyma_morphology1.01950879
66MP0002282_abnormal_trachea_morphology1.01810652
67MP0003937_abnormal_limbs/digits/tail_de1.01050325
68MP0006036_abnormal_mitochondrial_physio1.00906242
69MP0003186_abnormal_redox_activity1.00312127
70MP0002064_seizures0.98792872
71MP0005499_abnormal_olfactory_system0.98260216
72MP0005394_taste/olfaction_phenotype0.98260216
73MP0008058_abnormal_DNA_repair0.97778102
74MP0000049_abnormal_middle_ear0.96255014
75MP0002734_abnormal_mechanical_nocicepti0.95850356
76MP0002752_abnormal_somatic_nervous0.94605526
77MP0001501_abnormal_sleep_pattern0.93382953
78MP0002095_abnormal_skin_pigmentation0.92472729
79MP0002254_reproductive_system_inflammat0.92257865
80MP0002233_abnormal_nose_morphology0.91378114
81MP0002733_abnormal_thermal_nociception0.90964346
82MP0004145_abnormal_muscle_electrophysio0.89959870
83MP0003567_abnormal_fetal_cardiomyocyte0.89801564
84MP0005391_vision/eye_phenotype0.89501081
85MP0003137_abnormal_impulse_conducting0.85898866
86MP0000647_abnormal_sebaceous_gland0.85798471
87MP0002063_abnormal_learning/memory/cond0.85559097
88MP0003283_abnormal_digestive_organ0.85186226
89MP0003938_abnormal_ear_development0.84687991
90MP0009697_abnormal_copulation0.83189385
91MP0003635_abnormal_synaptic_transmissio0.82958358
92MP0003786_premature_aging0.81726324
93MP0005332_abnormal_amino_acid0.81575557
94MP0000026_abnormal_inner_ear0.81493233
95MP0005410_abnormal_fertilization0.81000736
96MP0005386_behavior/neurological_phenoty0.80358335
97MP0004924_abnormal_behavior0.80358335
98MP0002928_abnormal_bile_duct0.79097271
99MP0000653_abnormal_sex_gland0.78680166
100MP0001929_abnormal_gametogenesis0.78191700

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.36337776
2Pancreatic fibrosis (HP:0100732)4.14448805
3True hermaphroditism (HP:0010459)4.04999514
4Acute necrotizing encephalopathy (HP:0006965)4.04817760
5Molar tooth sign on MRI (HP:0002419)3.95704448
6Abnormality of midbrain morphology (HP:0002418)3.95704448
7Nephronophthisis (HP:0000090)3.86284888
8Acute encephalopathy (HP:0006846)3.62323620
9Progressive macrocephaly (HP:0004481)3.57741656
10Abnormal mitochondria in muscle tissue (HP:0008316)3.45954046
11Mitochondrial inheritance (HP:0001427)3.44052672
12Medial flaring of the eyebrow (HP:0010747)3.34545287
13Abnormality of the renal medulla (HP:0100957)3.23114858
14Increased CSF lactate (HP:0002490)3.17811374
15Hepatocellular necrosis (HP:0001404)3.01775272
16Pendular nystagmus (HP:0012043)2.92388768
17Hepatic necrosis (HP:0002605)2.87423783
18Type II lissencephaly (HP:0007260)2.79274203
19Colon cancer (HP:0003003)2.73698815
20Cystic liver disease (HP:0006706)2.65655976
21Cerebral edema (HP:0002181)2.56356077
22Congenital primary aphakia (HP:0007707)2.55953912
23Gait imbalance (HP:0002141)2.55313004
24Abnormality of the renal cortex (HP:0011035)2.55301438
25Sclerocornea (HP:0000647)2.54977667
26Hyperglycinemia (HP:0002154)2.54533602
27Increased hepatocellular lipid droplets (HP:0006565)2.50598865
28Lipid accumulation in hepatocytes (HP:0006561)2.50334930
29Chronic hepatic failure (HP:0100626)2.45805008
30Congenital stationary night blindness (HP:0007642)2.44943034
31Nephrogenic diabetes insipidus (HP:0009806)2.41471707
32Optic disc pallor (HP:0000543)2.39847028
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.38322922
343-Methylglutaconic aciduria (HP:0003535)2.33306034
35Abolished electroretinogram (ERG) (HP:0000550)2.33148690
36Renal cortical cysts (HP:0000803)2.29896277
37Postaxial foot polydactyly (HP:0001830)2.29603406
38Anencephaly (HP:0002323)2.28642860
39Abnormality of macular pigmentation (HP:0008002)2.25277245
40Abnormal biliary tract physiology (HP:0012439)2.25120053
41Bile duct proliferation (HP:0001408)2.25120053
42Attenuation of retinal blood vessels (HP:0007843)2.24631916
43Male pseudohermaphroditism (HP:0000037)2.23599716
44Postaxial hand polydactyly (HP:0001162)2.22573655
45Short tibia (HP:0005736)2.21410686
46Aplasia/Hypoplasia of the tibia (HP:0005772)2.17752554
47Tubular atrophy (HP:0000092)2.13124819
48Abnormality of the labia minora (HP:0012880)2.12727947
49Keratoconus (HP:0000563)2.10675130
50Increased corneal curvature (HP:0100692)2.10675130
51Congenital hepatic fibrosis (HP:0002612)2.10508252
52Abnormal rod and cone electroretinograms (HP:0008323)2.09517792
53Methylmalonic acidemia (HP:0002912)2.05284751
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05145025
55Abnormal drinking behavior (HP:0030082)2.03758025
56Polydipsia (HP:0001959)2.03758025
57Genital tract atresia (HP:0001827)1.99306100
58Type 2 muscle fiber atrophy (HP:0003554)1.99077538
59Lissencephaly (HP:0001339)1.98051057
60Hypothermia (HP:0002045)1.97841084
61Vaginal atresia (HP:0000148)1.97290267
62Cerebellar dysplasia (HP:0007033)1.97206408
63Glycosuria (HP:0003076)1.96072546
64Abnormality of urine glucose concentration (HP:0011016)1.96072546
65Aplasia/hypoplasia of the uterus (HP:0008684)1.95761970
66Optic nerve hypoplasia (HP:0000609)1.93608577
67Absent speech (HP:0001344)1.92469517
68Respiratory failure (HP:0002878)1.90422022
69Supernumerary spleens (HP:0009799)1.86226189
70Increased serum lactate (HP:0002151)1.85241559
71Hyperventilation (HP:0002883)1.85234883
72Hemiparesis (HP:0001269)1.84116937
73Occipital encephalocele (HP:0002085)1.84024602
74Lactic acidosis (HP:0003128)1.83453200
75Intestinal atresia (HP:0011100)1.81618603
76Renal Fanconi syndrome (HP:0001994)1.79952939
77Lethargy (HP:0001254)1.79571527
78Tubulointerstitial nephritis (HP:0001970)1.79278103
79Polyphagia (HP:0002591)1.76430379
80Small hand (HP:0200055)1.75325605
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73787599
82Narrow forehead (HP:0000341)1.73642037
83Dandy-Walker malformation (HP:0001305)1.73053122
84Hypomagnesemia (HP:0002917)1.72544900
85Aplasia/Hypoplasia of the spleen (HP:0010451)1.72489828
86Specific learning disability (HP:0001328)1.71843904
87Severe muscular hypotonia (HP:0006829)1.71749440
88Furrowed tongue (HP:0000221)1.71722137
89Congenital, generalized hypertrichosis (HP:0004540)1.71680416
90Methylmalonic aciduria (HP:0012120)1.71399012
91Retinal dysplasia (HP:0007973)1.70991437
92Leukodystrophy (HP:0002415)1.70938807
93Polyuria (HP:0000103)1.70859308
94Exertional dyspnea (HP:0002875)1.70526338
95Hypoplasia of the pons (HP:0012110)1.70007667
96Abnormality of renal resorption (HP:0011038)1.69339079
97Decreased central vision (HP:0007663)1.68903416
98Abnormality of the phalanges of the 2nd finger (HP:0009541)1.68301216
99Asplenia (HP:0001746)1.65118091
100Preaxial hand polydactyly (HP:0001177)1.64750601

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.82156053
2FRK3.59922043
3WNK33.20952799
4NUAK13.02888568
5PINK12.66319168
6VRK22.51522593
7GRK12.29951010
8MAP3K42.28675971
9ADRBK22.25151702
10TRIM282.11598002
11TNIK1.94822460
12BCR1.94819058
13INSRR1.83135006
14MAP2K71.83020051
15WNK41.76359121
16STK391.72798626
17MAP3K121.64088910
18BCKDK1.62039591
19DYRK21.53957846
20MAPK131.52207781
21VRK11.45476988
22ZAK1.39937666
23EIF2AK31.39917879
24EPHA41.37419734
25PLK21.36706266
26BMPR1B1.34044246
27CASK1.33875183
28ERBB31.32609802
29OXSR11.31594738
30CSNK1G21.24517984
31CSNK1G31.22519785
32PAK31.21748382
33SRPK11.18763235
34PRKCE1.14115263
35CSNK1G11.12922335
36PLK41.07469645
37CSNK1A1L1.05566790
38GRK71.02619978
39MKNK21.00332302
40CDK191.00231134
41CAMKK21.00174998
42TAOK30.98913187
43PLK30.97938617
44TIE10.93476691
45MUSK0.92997617
46FGFR20.88400811
47PRKCG0.86327741
48MARK10.84701542
49MAP2K40.82955478
50FLT30.79706958
51DAPK20.78296790
52MKNK10.77763201
53STK38L0.77389530
54PHKG10.74919488
55PHKG20.74919488
56EIF2AK10.74241700
57DYRK30.74229127
58TXK0.70231272
59PIM20.69740345
60BRSK20.68697581
61AKT30.68551322
62ADRBK10.67606307
63RPS6KA40.65557677
64PIK3CA0.61992700
65PNCK0.59522549
66STK160.57333771
67PRKACA0.56967404
68NEK10.56328178
69MINK10.55206710
70ACVR1B0.52377102
71TLK10.50995611
72PLK10.49994011
73CAMK2A0.48911021
74NTRK30.47123665
75OBSCN0.47061483
76NME10.45386819
77LIMK10.44071597
78RPS6KA50.43674683
79SIK30.43639184
80MST40.43504850
81EPHA30.42212942
82CSNK1A10.41222111
83PKN10.41104091
84FER0.40376310
85PRKG10.38030417
86NTRK20.37804202
87PRKCQ0.35482886
88TEC0.35224525
89CSNK2A10.34775512
90CDC70.33661760
91PRKCA0.32021207
92WEE10.30703508
93CAMK10.30238874
94IKBKB0.28684241
95PDK20.28604119
96STK30.27989697
97CAMK2D0.27380365
98TGFBR10.26533443
99CSNK2A20.25867863
100PRKACG0.25636119

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.95922031
2Protein export_Homo sapiens_hsa030603.31529872
3Parkinsons disease_Homo sapiens_hsa050123.19996594
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.52288196
5RNA polymerase_Homo sapiens_hsa030202.24095766
6Phototransduction_Homo sapiens_hsa047442.23204936
7Proteasome_Homo sapiens_hsa030502.18599324
8Ribosome_Homo sapiens_hsa030102.12515242
9Huntingtons disease_Homo sapiens_hsa050162.12337790
10Alzheimers disease_Homo sapiens_hsa050101.98547908
11RNA degradation_Homo sapiens_hsa030181.88439164
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87925683
13Homologous recombination_Homo sapiens_hsa034401.86807685
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81111157
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.74289535
16Propanoate metabolism_Homo sapiens_hsa006401.73852944
17Cardiac muscle contraction_Homo sapiens_hsa042601.70173800
18Fatty acid elongation_Homo sapiens_hsa000621.66358127
19Fanconi anemia pathway_Homo sapiens_hsa034601.65300369
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.64368557
21Butanoate metabolism_Homo sapiens_hsa006501.63443580
22Basal transcription factors_Homo sapiens_hsa030221.60987557
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56508684
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53555264
25Nicotine addiction_Homo sapiens_hsa050331.53387171
26Linoleic acid metabolism_Homo sapiens_hsa005911.52515482
27Asthma_Homo sapiens_hsa053101.50373033
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40566458
29Nitrogen metabolism_Homo sapiens_hsa009101.40308531
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36724754
31Collecting duct acid secretion_Homo sapiens_hsa049661.31738077
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30459557
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20302517
34Selenocompound metabolism_Homo sapiens_hsa004501.15564822
35Regulation of autophagy_Homo sapiens_hsa041401.15350039
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14786191
37Steroid biosynthesis_Homo sapiens_hsa001001.14743937
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13492764
39Peroxisome_Homo sapiens_hsa041461.11633233
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08724259
41Chemical carcinogenesis_Homo sapiens_hsa052041.06323116
42Non-homologous end-joining_Homo sapiens_hsa034501.05684471
43Ether lipid metabolism_Homo sapiens_hsa005651.05628842
44Caffeine metabolism_Homo sapiens_hsa002321.02443226
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.00335063
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99955623
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99870151
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.99311357
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99157568
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97189428
51Retinol metabolism_Homo sapiens_hsa008300.97040102
52Tryptophan metabolism_Homo sapiens_hsa003800.93640913
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89935223
54GABAergic synapse_Homo sapiens_hsa047270.89220262
55Morphine addiction_Homo sapiens_hsa050320.89179074
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.87820543
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86558449
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86057073
59Taste transduction_Homo sapiens_hsa047420.85892382
60Olfactory transduction_Homo sapiens_hsa047400.85362601
61Pyrimidine metabolism_Homo sapiens_hsa002400.84177418
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84009555
63Metabolic pathways_Homo sapiens_hsa011000.84002169
64Purine metabolism_Homo sapiens_hsa002300.83972169
65Mismatch repair_Homo sapiens_hsa034300.78984107
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78913387
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.77773326
68Glutamatergic synapse_Homo sapiens_hsa047240.73320261
69One carbon pool by folate_Homo sapiens_hsa006700.72262700
70Circadian entrainment_Homo sapiens_hsa047130.68147924
71Serotonergic synapse_Homo sapiens_hsa047260.67368779
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66389361
73Nucleotide excision repair_Homo sapiens_hsa034200.66105022
74Arachidonic acid metabolism_Homo sapiens_hsa005900.64045604
75Fat digestion and absorption_Homo sapiens_hsa049750.63199777
76Rheumatoid arthritis_Homo sapiens_hsa053230.62471943
77Base excision repair_Homo sapiens_hsa034100.60050304
78Type I diabetes mellitus_Homo sapiens_hsa049400.59690297
79Spliceosome_Homo sapiens_hsa030400.59085510
80Glutathione metabolism_Homo sapiens_hsa004800.58192271
81Arginine and proline metabolism_Homo sapiens_hsa003300.56912259
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56105378
83Sulfur metabolism_Homo sapiens_hsa009200.54773856
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54480523
85Hedgehog signaling pathway_Homo sapiens_hsa043400.53490764
86RNA transport_Homo sapiens_hsa030130.52610085
87beta-Alanine metabolism_Homo sapiens_hsa004100.49044421
88Dopaminergic synapse_Homo sapiens_hsa047280.47916291
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47904047
90Mineral absorption_Homo sapiens_hsa049780.44840324
91Basal cell carcinoma_Homo sapiens_hsa052170.44803878
92Fatty acid metabolism_Homo sapiens_hsa012120.44383708
93Allograft rejection_Homo sapiens_hsa053300.41920327
94Synaptic vesicle cycle_Homo sapiens_hsa047210.40711244
95Insulin secretion_Homo sapiens_hsa049110.39527011
96Circadian rhythm_Homo sapiens_hsa047100.39289338
97Autoimmune thyroid disease_Homo sapiens_hsa053200.38423816
98Cocaine addiction_Homo sapiens_hsa050300.35397932
99Salivary secretion_Homo sapiens_hsa049700.30906495
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29191839

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