ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cullin deneddylation (GO:0010388)	4.90389331
2	protein localization to cilium (GO:0061512)	4.62733481
3	protein deneddylation (GO:0000338)	4.41086698
4	platelet dense granule organization (GO:0060155)	4.20194894
5	protein complex biogenesis (GO:0070271)	4.10023124
6	behavioral response to nicotine (GO:0035095)	4.01496153
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.96074540
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.95171241
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.83136920
10	ATP synthesis coupled proton transport (GO:0015986)	3.75971244
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.75971244
12	epithelial cilium movement (GO:0003351)	3.72302310
13	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.72156771
14	NADH dehydrogenase complex assembly (GO:0010257)	3.72156771
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.72156771
16	mitochondrial respiratory chain complex assembly (GO:0033108)	3.63409769
17	water-soluble vitamin biosynthetic process (GO:0042364)	3.61206499
18	DNA double-strand break processing (GO:0000729)	3.55349429
19	pyrimidine nucleobase catabolic process (GO:0006208)	3.51727454
20	response to pheromone (GO:0019236)	3.45175389
21	intraciliary transport (GO:0042073)	3.42849889
22	magnesium ion transport (GO:0015693)	3.41055841
23	neural tube formation (GO:0001841)	3.35793150
24	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.33796414
25	protein-cofactor linkage (GO:0018065)	3.30535502
26	electron transport chain (GO:0022900)	3.29631030
27	respiratory electron transport chain (GO:0022904)	3.28984000
28	proteasome assembly (GO:0043248)	3.26743613
29	nonmotile primary cilium assembly (GO:0035058)	3.23038985
30	C4-dicarboxylate transport (GO:0015740)	3.22860746
31	DNA integration (GO:0015074)	3.17193713
32	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.16857908
33	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.11804821
34	protein neddylation (GO:0045116)	3.08306987
35	cytochrome complex assembly (GO:0017004)	3.07322400
36	mannosylation (GO:0097502)	3.04255777
37	positive regulation of mitochondrial fission (GO:0090141)	3.01833992
38	nucleobase catabolic process (GO:0046113)	3.00864020
39	axoneme assembly (GO:0035082)	2.99437702
40	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.94778967
41	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.94778967
42	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.93979304
43	GPI anchor metabolic process (GO:0006505)	2.92157308
44	respiratory chain complex IV assembly (GO:0008535)	2.89299584
45	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.88996594
46	termination of RNA polymerase III transcription (GO:0006386)	2.88996594
47	limb bud formation (GO:0060174)	2.86333865
48	DNA deamination (GO:0045006)	2.84555202
49	somite development (GO:0061053)	2.83576922
50	preassembly of GPI anchor in ER membrane (GO:0016254)	2.81148323
51	cilium movement (GO:0003341)	2.79768262
52	cilium morphogenesis (GO:0060271)	2.79061247
53	fucose catabolic process (GO:0019317)	2.76768760
54	L-fucose metabolic process (GO:0042354)	2.76768760
55	L-fucose catabolic process (GO:0042355)	2.76768760
56	cornea development in camera-type eye (GO:0061303)	2.74576261
57	hydrogen ion transmembrane transport (GO:1902600)	2.73461170
58	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.72692393
59	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.72692393
60	S-adenosylmethionine metabolic process (GO:0046500)	2.72477535
61	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.71470860
62	cilium organization (GO:0044782)	2.70153620
63	detection of light stimulus involved in visual perception (GO:0050908)	2.68098496
64	detection of light stimulus involved in sensory perception (GO:0050962)	2.68098496
65	proton transport (GO:0015992)	2.67712245
66	chaperone-mediated protein transport (GO:0072321)	2.67380909
67	neuronal action potential propagation (GO:0019227)	2.67136410
68	regulation of cilium movement (GO:0003352)	2.66925811
69	cilium assembly (GO:0042384)	2.66917334
70	negative regulation of mast cell activation (GO:0033004)	2.66717595
71	hydrogen transport (GO:0006818)	2.66206546
72	indolalkylamine metabolic process (GO:0006586)	2.66107134
73	retinal ganglion cell axon guidance (GO:0031290)	2.65839636
74	gamma-aminobutyric acid transport (GO:0015812)	2.58609809
75	regulation of mitochondrial translation (GO:0070129)	2.57599604
76	kidney morphogenesis (GO:0060993)	2.56557984
77	negative regulation of heart rate (GO:0010459)	2.54816739
78	ubiquinone metabolic process (GO:0006743)	2.53501820
79	ubiquinone biosynthetic process (GO:0006744)	2.52833984
80	regulation of feeding behavior (GO:0060259)	2.50961936
81	neuron fate determination (GO:0048664)	2.49765906
82	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.47920948
83	centriole replication (GO:0007099)	2.47132863
84	GPI anchor biosynthetic process (GO:0006506)	2.44949208
85	photoreceptor cell maintenance (GO:0045494)	2.44920308
86	intracellular protein transmembrane import (GO:0044743)	2.43584202
87	glycosphingolipid biosynthetic process (GO:0006688)	2.43201261
88	anterograde synaptic vesicle transport (GO:0048490)	2.42984054
89	behavioral response to ethanol (GO:0048149)	2.42591436
90	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.42033881
91	aldehyde catabolic process (GO:0046185)	2.41896548
92	synaptic transmission, cholinergic (GO:0007271)	2.41593801
93	negative regulation of telomere maintenance (GO:0032205)	2.40857560
94	peptidyl-histidine modification (GO:0018202)	2.40711959
95	positive regulation of prostaglandin secretion (GO:0032308)	2.40435346
96	embryonic epithelial tube formation (GO:0001838)	2.39307832
97	primary amino compound metabolic process (GO:1901160)	2.38933106
98	transmission of nerve impulse (GO:0019226)	2.38832666
99	glycolipid biosynthetic process (GO:0009247)	2.38737795
100	organelle disassembly (GO:1903008)	2.37535705

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.53802150
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.03253799
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.97110316
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.96744466
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.71571501
6	VDR_22108803_ChIP-Seq_LS180_Human	2.70423645
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.69479732
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.60317682
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.57144985
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.51612884
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.50962841
12	EWS_26573619_Chip-Seq_HEK293_Human	2.43246003
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.30208103
14	FUS_26573619_Chip-Seq_HEK293_Human	2.22345174
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.14266805
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.10463957
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.10227364
18	P300_19829295_ChIP-Seq_ESCs_Human	2.08147305
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.98018575
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.97270511
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.96047865
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91317788
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.88245743
24	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.74494731
25	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.64550597
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.63621705
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.62325198
28	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.62304940
29	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.59926970
30	VDR_23849224_ChIP-Seq_CD4+_Human	1.59535783
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56029232
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54225310
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.53436802
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52485405
35	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.50394476
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.49250741
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.48884364
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.47799753
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.46462872
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46462872
41	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46418221
42	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.46196274
43	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.39793654
44	RNF2_27304074_Chip-Seq_NSC_Mouse	1.39076108
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38948685
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38948685
47	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.38287932
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.37786344
49	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.36625822
50	BCAT_22108803_ChIP-Seq_LS180_Human	1.35617697
51	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.35308078
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34392972
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34392972
54	AR_25329375_ChIP-Seq_VCAP_Human	1.32825831
55	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.32525587
56	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.29394084
57	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28499851
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26830654
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25897539
60	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23951766
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23826473
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.22239766
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.21650301
64	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.21275278
65	FOXP3_21729870_ChIP-Seq_TREG_Human	1.20756518
66	SMAD4_21799915_ChIP-Seq_A2780_Human	1.19729559
67	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19222896
68	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19023233
69	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.17832140
70	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.17115348
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17107211
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16851761
73	STAT3_23295773_ChIP-Seq_U87_Human	1.16208063
74	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.16181583
75	AR_20517297_ChIP-Seq_VCAP_Human	1.14398434
76	TCF4_23295773_ChIP-Seq_U87_Human	1.11893237
77	NCOR_22424771_ChIP-Seq_293T_Human	1.11469254
78	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11429989
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.11268457
80	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.10146808
81	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09769566
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08248695
83	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.08114801
84	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.05670237
85	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05606689
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04634514
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04539657
88	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.04457048
89	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.04302790
90	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03656678
91	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.03462853
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03279151
93	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.03217806
94	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02726654
95	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.01350198
96	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.01122455
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00697351
98	HTT_18923047_ChIP-ChIP_STHdh_Human	1.00304651
99	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.00044113
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.99415381

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.20839713
2	MP0006292_abnormal_olfactory_placode	2.79102696
3	MP0006072_abnormal_retinal_apoptosis	2.75473997
4	MP0002102_abnormal_ear_morphology	2.68005263
5	MP0003195_calcinosis	2.64816107
6	MP0008877_abnormal_DNA_methylation	2.53553220
7	MP0004147_increased_porphyrin_level	2.40050880
8	MP0003122_maternal_imprinting	2.35035048
9	MP0005551_abnormal_eye_electrophysiolog	2.16240055
10	MP0002837_dystrophic_cardiac_calcinosis	2.12422690
11	MP0005084_abnormal_gallbladder_morpholo	2.11932516
12	MP0003787_abnormal_imprinting	2.11113441
13	MP0005253_abnormal_eye_physiology	2.02368048
14	MP0002876_abnormal_thyroid_physiology	1.98525742
15	MP0001968_abnormal_touch/_nociception	1.96102946
16	MP0002736_abnormal_nociception_after	1.94558017
17	MP0001529_abnormal_vocalization	1.91476658
18	MP0006276_abnormal_autonomic_nervous	1.86186554
19	MP0004133_heterotaxia	1.86060056
20	MP0005646_abnormal_pituitary_gland	1.85577900
21	MP0004142_abnormal_muscle_tone	1.79903704
22	MP0002938_white_spotting	1.71235647
23	MP0001984_abnormal_olfaction	1.70917916
24	MP0003121_genomic_imprinting	1.68950918
25	MP0000631_abnormal_neuroendocrine_gland	1.68112894
26	MP0005645_abnormal_hypothalamus_physiol	1.66553616
27	MP0003011_delayed_dark_adaptation	1.63588001
28	MP0008872_abnormal_physiological_respon	1.62429903
29	MP0010386_abnormal_urinary_bladder	1.58600314
30	MP0009046_muscle_twitch	1.57034597
31	MP0003646_muscle_fatigue	1.56064367
32	MP0002272_abnormal_nervous_system	1.55130379
33	MP0002234_abnormal_pharynx_morphology	1.54651987
34	MP0009745_abnormal_behavioral_response	1.49654737
35	MP0002751_abnormal_autonomic_nervous	1.47015472
36	MP0001486_abnormal_startle_reflex	1.43257256
37	MP0008995_early_reproductive_senescence	1.41861074
38	MP0008875_abnormal_xenobiotic_pharmacok	1.40693031
39	MP0005367_renal/urinary_system_phenotyp	1.40685458
40	MP0000516_abnormal_urinary_system	1.40685458
41	MP0002638_abnormal_pupillary_reflex	1.39227826
42	MP0001986_abnormal_taste_sensitivity	1.38462358
43	MP0003136_yellow_coat_color	1.37604393
44	MP0001293_anophthalmia	1.32296509
45	MP0001764_abnormal_homeostasis	1.31799669
46	MP0002557_abnormal_social/conspecific_i	1.30366241
47	MP0002160_abnormal_reproductive_system	1.25779193
48	MP0008789_abnormal_olfactory_epithelium	1.24990867
49	MP0005389_reproductive_system_phenotype	1.21417091
50	MP0003718_maternal_effect	1.15960181
51	MP0002822_catalepsy	1.12629337
52	MP0000427_abnormal_hair_cycle	1.11569641
53	MP0001970_abnormal_pain_threshold	1.09141908
54	MP0001905_abnormal_dopamine_level	1.09137772
55	MP0005195_abnormal_posterior_eye	1.08185329
56	MP0002735_abnormal_chemical_nociception	1.07389207
57	MP0002572_abnormal_emotion/affect_behav	1.06973609
58	MP0004215_abnormal_myocardial_fiber	1.06822003
59	MP0000778_abnormal_nervous_system	1.05441523
60	MP0004019_abnormal_vitamin_homeostasis	1.04249794
61	MP0001919_abnormal_reproductive_system	1.04032738
62	MP0004885_abnormal_endolymph	1.02816036
63	MP0002184_abnormal_innervation	1.02285041
64	MP0006035_abnormal_mitochondrial_morpho	1.02110900
65	MP0002653_abnormal_ependyma_morphology	1.01950879
66	MP0002282_abnormal_trachea_morphology	1.01810652
67	MP0003937_abnormal_limbs/digits/tail_de	1.01050325
68	MP0006036_abnormal_mitochondrial_physio	1.00906242
69	MP0003186_abnormal_redox_activity	1.00312127
70	MP0002064_seizures	0.98792872
71	MP0005499_abnormal_olfactory_system	0.98260216
72	MP0005394_taste/olfaction_phenotype	0.98260216
73	MP0008058_abnormal_DNA_repair	0.97778102
74	MP0000049_abnormal_middle_ear	0.96255014
75	MP0002734_abnormal_mechanical_nocicepti	0.95850356
76	MP0002752_abnormal_somatic_nervous	0.94605526
77	MP0001501_abnormal_sleep_pattern	0.93382953
78	MP0002095_abnormal_skin_pigmentation	0.92472729
79	MP0002254_reproductive_system_inflammat	0.92257865
80	MP0002233_abnormal_nose_morphology	0.91378114
81	MP0002733_abnormal_thermal_nociception	0.90964346
82	MP0004145_abnormal_muscle_electrophysio	0.89959870
83	MP0003567_abnormal_fetal_cardiomyocyte	0.89801564
84	MP0005391_vision/eye_phenotype	0.89501081
85	MP0003137_abnormal_impulse_conducting	0.85898866
86	MP0000647_abnormal_sebaceous_gland	0.85798471
87	MP0002063_abnormal_learning/memory/cond	0.85559097
88	MP0003283_abnormal_digestive_organ	0.85186226
89	MP0003938_abnormal_ear_development	0.84687991
90	MP0009697_abnormal_copulation	0.83189385
91	MP0003635_abnormal_synaptic_transmissio	0.82958358
92	MP0003786_premature_aging	0.81726324
93	MP0005332_abnormal_amino_acid	0.81575557
94	MP0000026_abnormal_inner_ear	0.81493233
95	MP0005410_abnormal_fertilization	0.81000736
96	MP0005386_behavior/neurological_phenoty	0.80358335
97	MP0004924_abnormal_behavior	0.80358335
98	MP0002928_abnormal_bile_duct	0.79097271
99	MP0000653_abnormal_sex_gland	0.78680166
100	MP0001929_abnormal_gametogenesis	0.78191700

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.36337776
2	Pancreatic fibrosis (HP:0100732)	4.14448805
3	True hermaphroditism (HP:0010459)	4.04999514
4	Acute necrotizing encephalopathy (HP:0006965)	4.04817760
5	Molar tooth sign on MRI (HP:0002419)	3.95704448
6	Abnormality of midbrain morphology (HP:0002418)	3.95704448
7	Nephronophthisis (HP:0000090)	3.86284888
8	Acute encephalopathy (HP:0006846)	3.62323620
9	Progressive macrocephaly (HP:0004481)	3.57741656
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.45954046
11	Mitochondrial inheritance (HP:0001427)	3.44052672
12	Medial flaring of the eyebrow (HP:0010747)	3.34545287
13	Abnormality of the renal medulla (HP:0100957)	3.23114858
14	Increased CSF lactate (HP:0002490)	3.17811374
15	Hepatocellular necrosis (HP:0001404)	3.01775272
16	Pendular nystagmus (HP:0012043)	2.92388768
17	Hepatic necrosis (HP:0002605)	2.87423783
18	Type II lissencephaly (HP:0007260)	2.79274203
19	Colon cancer (HP:0003003)	2.73698815
20	Cystic liver disease (HP:0006706)	2.65655976
21	Cerebral edema (HP:0002181)	2.56356077
22	Congenital primary aphakia (HP:0007707)	2.55953912
23	Gait imbalance (HP:0002141)	2.55313004
24	Abnormality of the renal cortex (HP:0011035)	2.55301438
25	Sclerocornea (HP:0000647)	2.54977667
26	Hyperglycinemia (HP:0002154)	2.54533602
27	Increased hepatocellular lipid droplets (HP:0006565)	2.50598865
28	Lipid accumulation in hepatocytes (HP:0006561)	2.50334930
29	Chronic hepatic failure (HP:0100626)	2.45805008
30	Congenital stationary night blindness (HP:0007642)	2.44943034
31	Nephrogenic diabetes insipidus (HP:0009806)	2.41471707
32	Optic disc pallor (HP:0000543)	2.39847028
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.38322922
34	3-Methylglutaconic aciduria (HP:0003535)	2.33306034
35	Abolished electroretinogram (ERG) (HP:0000550)	2.33148690
36	Renal cortical cysts (HP:0000803)	2.29896277
37	Postaxial foot polydactyly (HP:0001830)	2.29603406
38	Anencephaly (HP:0002323)	2.28642860
39	Abnormality of macular pigmentation (HP:0008002)	2.25277245
40	Abnormal biliary tract physiology (HP:0012439)	2.25120053
41	Bile duct proliferation (HP:0001408)	2.25120053
42	Attenuation of retinal blood vessels (HP:0007843)	2.24631916
43	Male pseudohermaphroditism (HP:0000037)	2.23599716
44	Postaxial hand polydactyly (HP:0001162)	2.22573655
45	Short tibia (HP:0005736)	2.21410686
46	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.17752554
47	Tubular atrophy (HP:0000092)	2.13124819
48	Abnormality of the labia minora (HP:0012880)	2.12727947
49	Increased corneal curvature (HP:0100692)	2.10675130
50	Keratoconus (HP:0000563)	2.10675130
51	Congenital hepatic fibrosis (HP:0002612)	2.10508252
52	Abnormal rod and cone electroretinograms (HP:0008323)	2.09517792
53	Methylmalonic acidemia (HP:0002912)	2.05284751
54	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.05145025
55	Abnormal drinking behavior (HP:0030082)	2.03758025
56	Polydipsia (HP:0001959)	2.03758025
57	Genital tract atresia (HP:0001827)	1.99306100
58	Type 2 muscle fiber atrophy (HP:0003554)	1.99077538
59	Lissencephaly (HP:0001339)	1.98051057
60	Hypothermia (HP:0002045)	1.97841084
61	Vaginal atresia (HP:0000148)	1.97290267
62	Cerebellar dysplasia (HP:0007033)	1.97206408
63	Abnormality of urine glucose concentration (HP:0011016)	1.96072546
64	Glycosuria (HP:0003076)	1.96072546
65	Aplasia/hypoplasia of the uterus (HP:0008684)	1.95761970
66	Optic nerve hypoplasia (HP:0000609)	1.93608577
67	Absent speech (HP:0001344)	1.92469517
68	Respiratory failure (HP:0002878)	1.90422022
69	Supernumerary spleens (HP:0009799)	1.86226189
70	Increased serum lactate (HP:0002151)	1.85241559
71	Hyperventilation (HP:0002883)	1.85234883
72	Hemiparesis (HP:0001269)	1.84116937
73	Occipital encephalocele (HP:0002085)	1.84024602
74	Lactic acidosis (HP:0003128)	1.83453200
75	Intestinal atresia (HP:0011100)	1.81618603
76	Renal Fanconi syndrome (HP:0001994)	1.79952939
77	Lethargy (HP:0001254)	1.79571527
78	Tubulointerstitial nephritis (HP:0001970)	1.79278103
79	Polyphagia (HP:0002591)	1.76430379
80	Small hand (HP:0200055)	1.75325605
81	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.73787599
82	Narrow forehead (HP:0000341)	1.73642037
83	Dandy-Walker malformation (HP:0001305)	1.73053122
84	Hypomagnesemia (HP:0002917)	1.72544900
85	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.72489828
86	Specific learning disability (HP:0001328)	1.71843904
87	Severe muscular hypotonia (HP:0006829)	1.71749440
88	Furrowed tongue (HP:0000221)	1.71722137
89	Congenital, generalized hypertrichosis (HP:0004540)	1.71680416
90	Methylmalonic aciduria (HP:0012120)	1.71399012
91	Retinal dysplasia (HP:0007973)	1.70991437
92	Leukodystrophy (HP:0002415)	1.70938807
93	Polyuria (HP:0000103)	1.70859308
94	Exertional dyspnea (HP:0002875)	1.70526338
95	Hypoplasia of the pons (HP:0012110)	1.70007667
96	Abnormality of renal resorption (HP:0011038)	1.69339079
97	Decreased central vision (HP:0007663)	1.68903416
98	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.68301216
99	Asplenia (HP:0001746)	1.65118091
100	Preaxial hand polydactyly (HP:0001177)	1.64750601

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.82156053
2	FRK	3.59922043
3	WNK3	3.20952799
4	NUAK1	3.02888568
5	PINK1	2.66319168
6	VRK2	2.51522593
7	GRK1	2.29951010
8	MAP3K4	2.28675971
9	ADRBK2	2.25151702
10	TRIM28	2.11598002
11	TNIK	1.94822460
12	BCR	1.94819058
13	INSRR	1.83135006
14	MAP2K7	1.83020051
15	WNK4	1.76359121
16	STK39	1.72798626
17	MAP3K12	1.64088910
18	BCKDK	1.62039591
19	DYRK2	1.53957846
20	MAPK13	1.52207781
21	VRK1	1.45476988
22	ZAK	1.39937666
23	EIF2AK3	1.39917879
24	EPHA4	1.37419734
25	PLK2	1.36706266
26	BMPR1B	1.34044246
27	CASK	1.33875183
28	ERBB3	1.32609802
29	OXSR1	1.31594738
30	CSNK1G2	1.24517984
31	CSNK1G3	1.22519785
32	PAK3	1.21748382
33	SRPK1	1.18763235
34	PRKCE	1.14115263
35	CSNK1G1	1.12922335
36	PLK4	1.07469645
37	CSNK1A1L	1.05566790
38	GRK7	1.02619978
39	MKNK2	1.00332302
40	CDK19	1.00231134
41	CAMKK2	1.00174998
42	TAOK3	0.98913187
43	PLK3	0.97938617
44	TIE1	0.93476691
45	MUSK	0.92997617
46	FGFR2	0.88400811
47	PRKCG	0.86327741
48	MARK1	0.84701542
49	MAP2K4	0.82955478
50	FLT3	0.79706958
51	DAPK2	0.78296790
52	MKNK1	0.77763201
53	STK38L	0.77389530
54	PHKG2	0.74919488
55	PHKG1	0.74919488
56	EIF2AK1	0.74241700
57	DYRK3	0.74229127
58	TXK	0.70231272
59	PIM2	0.69740345
60	BRSK2	0.68697581
61	AKT3	0.68551322
62	ADRBK1	0.67606307
63	RPS6KA4	0.65557677
64	PIK3CA	0.61992700
65	PNCK	0.59522549
66	STK16	0.57333771
67	PRKACA	0.56967404
68	NEK1	0.56328178
69	MINK1	0.55206710
70	ACVR1B	0.52377102
71	TLK1	0.50995611
72	PLK1	0.49994011
73	CAMK2A	0.48911021
74	NTRK3	0.47123665
75	OBSCN	0.47061483
76	NME1	0.45386819
77	LIMK1	0.44071597
78	RPS6KA5	0.43674683
79	SIK3	0.43639184
80	MST4	0.43504850
81	EPHA3	0.42212942
82	CSNK1A1	0.41222111
83	PKN1	0.41104091
84	FER	0.40376310
85	PRKG1	0.38030417
86	NTRK2	0.37804202
87	PRKCQ	0.35482886
88	TEC	0.35224525
89	CSNK2A1	0.34775512
90	CDC7	0.33661760
91	PRKCA	0.32021207
92	WEE1	0.30703508
93	CAMK1	0.30238874
94	IKBKB	0.28684241
95	PDK2	0.28604119
96	STK3	0.27989697
97	CAMK2D	0.27380365
98	TGFBR1	0.26533443
99	CSNK2A2	0.25867863
100	PRKACG	0.25636119

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.95922031
2	Protein export_Homo sapiens_hsa03060	3.31529872
3	Parkinsons disease_Homo sapiens_hsa05012	3.19996594
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.52288196
5	RNA polymerase_Homo sapiens_hsa03020	2.24095766
6	Phototransduction_Homo sapiens_hsa04744	2.23204936
7	Proteasome_Homo sapiens_hsa03050	2.18599324
8	Ribosome_Homo sapiens_hsa03010	2.12515242
9	Huntingtons disease_Homo sapiens_hsa05016	2.12337790
10	Alzheimers disease_Homo sapiens_hsa05010	1.98547908
11	RNA degradation_Homo sapiens_hsa03018	1.88439164
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.87925683
13	Homologous recombination_Homo sapiens_hsa03440	1.86807685
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.81111157
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.74289535
16	Propanoate metabolism_Homo sapiens_hsa00640	1.73852944
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.70173800
18	Fatty acid elongation_Homo sapiens_hsa00062	1.66358127
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.65300369
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.64368557
21	Butanoate metabolism_Homo sapiens_hsa00650	1.63443580
22	Basal transcription factors_Homo sapiens_hsa03022	1.60987557
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.56508684
24	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.53555264
25	Nicotine addiction_Homo sapiens_hsa05033	1.53387171
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.52515482
27	Asthma_Homo sapiens_hsa05310	1.50373033
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.40566458
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.40308531
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.36724754
31	Collecting duct acid secretion_Homo sapiens_hsa04966	1.31738077
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.30459557
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.20302517
34	Selenocompound metabolism_Homo sapiens_hsa00450	1.15564822
35	Regulation of autophagy_Homo sapiens_hsa04140	1.15350039
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.14786191
37	Steroid biosynthesis_Homo sapiens_hsa00100	1.14743937
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.13492764
39	Peroxisome_Homo sapiens_hsa04146	1.11633233
40	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.08724259
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.06323116
42	Non-homologous end-joining_Homo sapiens_hsa03450	1.05684471
43	Ether lipid metabolism_Homo sapiens_hsa00565	1.05628842
44	Caffeine metabolism_Homo sapiens_hsa00232	1.02443226
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.00335063
46	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.99955623
47	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.99870151
48	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.99311357
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99157568
50	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.97189428
51	Retinol metabolism_Homo sapiens_hsa00830	0.97040102
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.93640913
53	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.89935223
54	GABAergic synapse_Homo sapiens_hsa04727	0.89220262
55	Morphine addiction_Homo sapiens_hsa05032	0.89179074
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87820543
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.86558449
58	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.86057073
59	Taste transduction_Homo sapiens_hsa04742	0.85892382
60	Olfactory transduction_Homo sapiens_hsa04740	0.85362601
61	Pyrimidine metabolism_Homo sapiens_hsa00240	0.84177418
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84009555
63	Metabolic pathways_Homo sapiens_hsa01100	0.84002169
64	Purine metabolism_Homo sapiens_hsa00230	0.83972169
65	Mismatch repair_Homo sapiens_hsa03430	0.78984107
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.78913387
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.77773326
68	Glutamatergic synapse_Homo sapiens_hsa04724	0.73320261
69	One carbon pool by folate_Homo sapiens_hsa00670	0.72262700
70	Circadian entrainment_Homo sapiens_hsa04713	0.68147924
71	Serotonergic synapse_Homo sapiens_hsa04726	0.67368779
72	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.66389361
73	Nucleotide excision repair_Homo sapiens_hsa03420	0.66105022
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.64045604
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.63199777
76	Rheumatoid arthritis_Homo sapiens_hsa05323	0.62471943
77	Base excision repair_Homo sapiens_hsa03410	0.60050304
78	Type I diabetes mellitus_Homo sapiens_hsa04940	0.59690297
79	Spliceosome_Homo sapiens_hsa03040	0.59085510
80	Glutathione metabolism_Homo sapiens_hsa00480	0.58192271
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.56912259
82	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.56105378
83	Sulfur metabolism_Homo sapiens_hsa00920	0.54773856
84	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.54480523
85	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53490764
86	RNA transport_Homo sapiens_hsa03013	0.52610085
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49044421
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.47916291
89	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.47904047
90	Mineral absorption_Homo sapiens_hsa04978	0.44840324
91	Basal cell carcinoma_Homo sapiens_hsa05217	0.44803878
92	Fatty acid metabolism_Homo sapiens_hsa01212	0.44383708
93	Allograft rejection_Homo sapiens_hsa05330	0.41920327
94	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.40711244
95	Insulin secretion_Homo sapiens_hsa04911	0.39527011
96	Circadian rhythm_Homo sapiens_hsa04710	0.39289338
97	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.38423816
98	Cocaine addiction_Homo sapiens_hsa05030	0.35397932
99	Salivary secretion_Homo sapiens_hsa04970	0.30906495
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.29191839

RPL17P50

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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