RPL18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.66584974
2* viral transcription (GO:0019083)7.50946780
3* translational termination (GO:0006415)7.24175946
4ribosomal small subunit biogenesis (GO:0042274)6.67499011
5* translational elongation (GO:0006414)6.36683380
6maturation of SSU-rRNA (GO:0030490)6.26850413
7* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.12039922
8* protein targeting to ER (GO:0045047)5.97804423
9* cotranslational protein targeting to membrane (GO:0006613)5.97269285
10* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.81627001
11* establishment of protein localization to endoplasmic reticulum (GO:0072599)5.69789714
12* translational initiation (GO:0006413)5.68406249
13* viral life cycle (GO:0019058)5.64175631
14* cellular protein complex disassembly (GO:0043624)5.60085944
15* protein localization to endoplasmic reticulum (GO:0070972)5.59616831
16ribosomal large subunit biogenesis (GO:0042273)5.15447270
17* protein complex disassembly (GO:0043241)5.02078141
18* macromolecular complex disassembly (GO:0032984)4.68472610
19DNA deamination (GO:0045006)4.68375495
20formation of translation preinitiation complex (GO:0001731)4.64205853
21ribonucleoprotein complex biogenesis (GO:0022613)4.37737390
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.36217756
23DNA strand elongation involved in DNA replication (GO:0006271)4.33546460
24* nuclear-transcribed mRNA catabolic process (GO:0000956)4.33073084
25* translation (GO:0006412)4.12929946
26DNA strand elongation (GO:0022616)4.12271885
27* mRNA catabolic process (GO:0006402)4.10895020
28DNA unwinding involved in DNA replication (GO:0006268)4.09337328
29telomere maintenance via semi-conservative replication (GO:0032201)4.08574328
30energy coupled proton transport, down electrochemical gradient (GO:0015985)4.06556485
31ATP synthesis coupled proton transport (GO:0015986)4.06556485
32* RNA catabolic process (GO:0006401)3.93505920
33* protein targeting to membrane (GO:0006612)3.93193244
34DNA replication initiation (GO:0006270)3.86136595
35rRNA processing (GO:0006364)3.65543645
36rRNA metabolic process (GO:0016072)3.52648795
37telomere maintenance via recombination (GO:0000722)3.49598091
38pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.44859190
39folic acid-containing compound biosynthetic process (GO:0009396)3.44568523
40nucleobase biosynthetic process (GO:0046112)3.39006664
41regulation of mitochondrial translation (GO:0070129)3.31514393
42ribosome biogenesis (GO:0042254)3.28420223
43mitotic recombination (GO:0006312)3.25607795
44guanosine-containing compound biosynthetic process (GO:1901070)3.24540241
45negative regulation of RNA splicing (GO:0033119)3.23411938
46telomere maintenance via telomere lengthening (GO:0010833)3.21700499
47cellular component biogenesis (GO:0044085)3.20044604
48protein localization to kinetochore (GO:0034501)3.18623139
49spliceosomal snRNP assembly (GO:0000387)3.16800994
50establishment of integrated proviral latency (GO:0075713)3.15331812
51chaperone-mediated protein transport (GO:0072321)3.14167069
52* protein localization to membrane (GO:0072657)3.13666870
53IMP biosynthetic process (GO:0006188)3.11486703
54DNA replication checkpoint (GO:0000076)3.11072049
55nucleotide-excision repair, DNA gap filling (GO:0006297)3.11026259
56peptidyl-arginine omega-N-methylation (GO:0035247)3.10160084
57ribosome assembly (GO:0042255)3.09376092
58pseudouridine synthesis (GO:0001522)3.07544590
59establishment of protein localization to mitochondrial membrane (GO:0090151)3.06725843
60UTP biosynthetic process (GO:0006228)3.05831485
61oxidative phosphorylation (GO:0006119)3.05652156
62respiratory electron transport chain (GO:0022904)3.05570241
63mitotic nuclear envelope disassembly (GO:0007077)3.00847582
64regulation of translational fidelity (GO:0006450)2.99602702
65pyrimidine nucleotide catabolic process (GO:0006244)2.99493176
66deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.98391528
67purine nucleobase biosynthetic process (GO:0009113)2.96181703
68electron transport chain (GO:0022900)2.96033872
69DNA replication-dependent nucleosome organization (GO:0034723)2.95248588
70DNA replication-dependent nucleosome assembly (GO:0006335)2.95248588
71pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.94506442
72pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.93009949
73GDP-mannose metabolic process (GO:0019673)2.91742803
74negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90524025
75ncRNA 3-end processing (GO:0043628)2.84923163
76pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.84495831
77protein targeting to mitochondrion (GO:0006626)2.84312656
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.80415200
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.79341712
80pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.79316353
81GTP biosynthetic process (GO:0006183)2.79101681
82deoxyribonucleotide catabolic process (GO:0009264)2.79100804
83protein localization to chromosome, centromeric region (GO:0071459)2.78567025
84IMP metabolic process (GO:0046040)2.78526687
85proteasome assembly (GO:0043248)2.78367875
86rRNA transcription (GO:0009303)2.78361021
87base-excision repair, AP site formation (GO:0006285)2.77542625
88transcription-coupled nucleotide-excision repair (GO:0006283)2.76783456
89UTP metabolic process (GO:0046051)2.75467697
90spliceosomal complex assembly (GO:0000245)2.75403708
91deoxyribose phosphate catabolic process (GO:0046386)2.74321483
92nuclear envelope disassembly (GO:0051081)2.73745819
93membrane disassembly (GO:0030397)2.73745819
94CENP-A containing nucleosome assembly (GO:0034080)2.73132031
95RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.72269090
96mRNA splicing, via spliceosome (GO:0000398)2.72269090
97chromatin remodeling at centromere (GO:0031055)2.71656338
98RNA splicing, via transesterification reactions (GO:0000375)2.71270306
99establishment of protein localization to mitochondrion (GO:0072655)2.68919392
100exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.67475964
101* establishment of protein localization to membrane (GO:0090150)2.66678990
102pentose metabolic process (GO:0019321)2.66545348
103anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.65229514
104negative regulation of B cell apoptotic process (GO:0002903)2.64223888
105ncRNA processing (GO:0034470)2.63832989
106inner mitochondrial membrane organization (GO:0007007)2.63634901
107purine deoxyribonucleotide catabolic process (GO:0009155)2.62893167
108regulation of protein heterodimerization activity (GO:0043497)2.62497597
109DNA replication-independent nucleosome assembly (GO:0006336)2.62416191
110DNA replication-independent nucleosome organization (GO:0034724)2.62416191
111regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.62198037
112mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.61899375
113termination of RNA polymerase II transcription (GO:0006369)2.61744484
114histone arginine methylation (GO:0034969)2.61396158
115negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60676274
116negative regulation of ligase activity (GO:0051352)2.60676274
117positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60017504
118CTP biosynthetic process (GO:0006241)2.58888542
119CTP metabolic process (GO:0046036)2.58888542
120transcription elongation from RNA polymerase III promoter (GO:0006385)2.58628402
121termination of RNA polymerase III transcription (GO:0006386)2.58628402
122mitotic metaphase plate congression (GO:0007080)2.58371331
123pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.58338569
124negative regulation of DNA-templated transcription, elongation (GO:0032785)2.56562950
125* establishment of protein localization to organelle (GO:0072594)2.56490599
126* gene expression (GO:0010467)2.53497309
127ribonucleoprotein complex assembly (GO:0022618)2.52386172
128proline biosynthetic process (GO:0006561)2.52363547
129nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.52131876
130DNA duplex unwinding (GO:0032508)2.51853196
131DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.51434619
132* cellular component disassembly (GO:0022411)2.50958132
133ncRNA metabolic process (GO:0034660)2.50912088
134nucleobase-containing small molecule interconversion (GO:0015949)2.50344140
135GMP metabolic process (GO:0046037)2.49230411
136DNA geometric change (GO:0032392)2.49127764
137intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.48544808
138signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.48544808
139rRNA modification (GO:0000154)2.48506358
140negative regulation of mRNA processing (GO:0050686)2.48485178
141* protein targeting (GO:0006605)2.46873970
142viral mRNA export from host cell nucleus (GO:0046784)2.46702122
143signal transduction involved in DNA damage checkpoint (GO:0072422)2.46525451
144signal transduction involved in DNA integrity checkpoint (GO:0072401)2.46525451
145* protein localization to organelle (GO:0033365)2.46495223
146deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.44923397
147protein localization to mitochondrion (GO:0070585)2.44179279
148ribonucleoside triphosphate biosynthetic process (GO:0009201)2.43994730
149viral protein processing (GO:0019082)2.43993323
150base-excision repair (GO:0006284)2.42649377
151myeloid cell homeostasis (GO:0002262)2.42568968

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.73691289
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.33575363
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.05145736
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.14336668
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.92859693
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80250549
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80047402
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.78201252
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.74288127
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68343559
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.66904576
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.66680667
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56711773
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51189267
15* XRN2_22483619_ChIP-Seq_HELA_Human2.49729709
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45688011
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32810125
18* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31820976
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14957963
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13660317
21MYC_22102868_ChIP-Seq_BL_Human2.13182045
22VDR_23849224_ChIP-Seq_CD4+_Human2.10688113
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09104831
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02992124
25* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00058897
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99767787
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91127382
28DCP1A_22483619_ChIP-Seq_HELA_Human1.87633816
29* TTF2_22483619_ChIP-Seq_HELA_Human1.85482214
30* FOXP3_21729870_ChIP-Seq_TREG_Human1.84772851
31CIITA_25753668_ChIP-Seq_RAJI_Human1.72864165
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.72840685
33GABP_19822575_ChIP-Seq_HepG2_Human1.72626012
34VDR_21846776_ChIP-Seq_THP-1_Human1.70140729
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68024759
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63337005
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59311388
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59166523
39* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54271367
40LXR_22292898_ChIP-Seq_THP-1_Human1.53616650
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52951647
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52219119
43* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51798397
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.51620310
45* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48432146
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47969001
47ZNF263_19887448_ChIP-Seq_K562_Human1.47781696
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.45795719
49ELK1_19687146_ChIP-ChIP_HELA_Human1.42555397
50AR_21909140_ChIP-Seq_LNCAP_Human1.41234689
51* YY1_21170310_ChIP-Seq_MESCs_Mouse1.39533946
52* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39114507
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38964013
54* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36925109
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36806088
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36146198
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35960038
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35792249
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.35538564
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35152021
61* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32882730
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32558640
63KDM5A_27292631_Chip-Seq_BREAST_Human1.30803446
64P68_20966046_ChIP-Seq_HELA_Human1.27906648
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27801579
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27329614
67CTCF_18555785_ChIP-Seq_MESCs_Mouse1.27016617
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26686466
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25934388
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23490534
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.22463131
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21055502
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20475627
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.18887356
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.18840183
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16842574
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16416555
78* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16344343
79* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16228778
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.16121566
81* FOXP1_21924763_ChIP-Seq_HESCs_Human1.13624614
82CTCF_26484167_Chip-Seq_Bcells_Mouse1.13205863
83* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12522772
84SPI1_23547873_ChIP-Seq_NB4_Human1.12238218
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11326773
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10363498
87* RACK7_27058665_Chip-Seq_MCF-7_Human1.10293686
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08415494
89TFEB_21752829_ChIP-Seq_HELA_Human1.08018254
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06521239
91BCL6_27268052_Chip-Seq_Bcells_Human1.06325774
92* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04794273
93* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02967926
94VDR_24763502_ChIP-Seq_THP-1_Human1.02083898
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00497376
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.99719979
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99556204
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99455210
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99308343
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99028868
101TP63_19390658_ChIP-ChIP_HaCaT_Human0.98722169
102PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98694930
103BCOR_27268052_Chip-Seq_Bcells_Human0.97989319
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97942201
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96993222
106NCOR1_26117541_ChIP-Seq_K562_Human0.96569970
107UTX_26944678_Chip-Seq_JUKART_Human0.96256575
108MAF_26560356_Chip-Seq_TH1_Human0.96169566
109SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95627370
110* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93941486
111* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93677809
112CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93557511
113MAF_26560356_Chip-Seq_TH2_Human0.93293172
114KDM2B_26808549_Chip-Seq_DND41_Human0.93237401
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93032725
116* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92846194
117TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92080521
118IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91968111
119SCL_19346495_ChIP-Seq_HPC-7_Human0.91950521
120* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91283459
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90973256
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89487337
123* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87772838
124MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87653042
125MYC_18940864_ChIP-ChIP_HL60_Human0.87370440
126ELK3_25401928_ChIP-Seq_HUVEC_Human0.86992763
127* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83921449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.59710923
2MP0004957_abnormal_blastocyst_morpholog3.82470295
3MP0003111_abnormal_nucleus_morphology3.44600334
4MP0010094_abnormal_chromosome_stability3.33982559
5MP0003077_abnormal_cell_cycle3.29572587
6MP0002396_abnormal_hematopoietic_system2.69950236
7MP0008057_abnormal_DNA_replication2.65563637
8MP0010352_gastrointestinal_tract_polyps2.42192584
9MP0009379_abnormal_foot_pigmentation2.38917335
10MP0008058_abnormal_DNA_repair2.34827088
11MP0008007_abnormal_cellular_replicative2.31700718
12MP0008932_abnormal_embryonic_tissue2.10687590
13MP0000490_abnormal_crypts_of2.10528543
14MP0008995_early_reproductive_senescence1.97796760
15MP0003763_abnormal_thymus_physiology1.94252074
16MP0001730_embryonic_growth_arrest1.93806342
17MP0009333_abnormal_splenocyte_physiolog1.89918999
18MP0000350_abnormal_cell_proliferation1.86505462
19MP0004808_abnormal_hematopoietic_stem1.82554358
20MP0006292_abnormal_olfactory_placode1.79080285
21MP0001545_abnormal_hematopoietic_system1.70055744
22MP0005397_hematopoietic_system_phenotyp1.70055744
23MP0000566_synostosis1.62585667
24MP0003786_premature_aging1.59256344
25MP0002163_abnormal_gland_morphology1.56308563
26MP0003123_paternal_imprinting1.55823746
27MP0002398_abnormal_bone_marrow1.50092087
28MP0006054_spinal_hemorrhage1.49151996
29MP0000685_abnormal_immune_system1.49075554
30MP0002019_abnormal_tumor_incidence1.47459678
31MP0002249_abnormal_larynx_morphology1.44804210
32MP0000703_abnormal_thymus_morphology1.44796538
33MP0002722_abnormal_immune_system1.43563360
34MP0002796_impaired_skin_barrier1.43067039
35MP0000678_abnormal_parathyroid_gland1.40417022
36MP0001697_abnormal_embryo_size1.40218030
37MP0000313_abnormal_cell_death1.39394869
38MP0002080_prenatal_lethality1.37822407
39MP0006035_abnormal_mitochondrial_morpho1.36407587
40MP0004185_abnormal_adipocyte_glucose1.36061341
41MP0002132_abnormal_respiratory_system1.34902232
42MP0000689_abnormal_spleen_morphology1.33460956
43MP0005380_embryogenesis_phenotype1.30471055
44MP0001672_abnormal_embryogenesis/_devel1.30471055
45MP0010307_abnormal_tumor_latency1.29367426
46MP0003567_abnormal_fetal_cardiomyocyte1.29122092
47MP0006036_abnormal_mitochondrial_physio1.27005752
48MP0009278_abnormal_bone_marrow1.25485948
49MP0000858_altered_metastatic_potential1.25023015
50MP0000372_irregular_coat_pigmentation1.22499338
51MP0003806_abnormal_nucleotide_metabolis1.22228946
52MP0001346_abnormal_lacrimal_gland1.22000298
53MP0002085_abnormal_embryonic_tissue1.21803759
54MP0010030_abnormal_orbit_morphology1.21682441
55MP0005451_abnormal_body_composition1.21301427
56MP0002429_abnormal_blood_cell1.20196237
57MP0001835_abnormal_antigen_presentation1.20038290
58MP0003984_embryonic_growth_retardation1.19996011
59MP0002088_abnormal_embryonic_growth/wei1.17908879
60MP0002086_abnormal_extraembryonic_tissu1.17066988
61MP0004197_abnormal_fetal_growth/weight/1.16586456
62MP0001800_abnormal_humoral_immune1.14361238
63MP0002084_abnormal_developmental_patter1.14246055
64MP0000465_gastrointestinal_hemorrhage1.12251959
65MP0000716_abnormal_immune_system1.12243405
66MP0004858_abnormal_nervous_system1.10834143
67MP0000537_abnormal_urethra_morphology1.09927895
68MP0001853_heart_inflammation1.08890262
69MP0004381_abnormal_hair_follicle1.07979201
70MP0005075_abnormal_melanosome_morpholog1.03907576
71MP0002420_abnormal_adaptive_immunity1.03617399
72MP0005671_abnormal_response_to1.03589373
73MP0002405_respiratory_system_inflammati1.03221356
74MP0005023_abnormal_wound_healing1.02530374
75MP0001819_abnormal_immune_cell1.01607141
76MP0001293_anophthalmia1.00979188
77MP0005174_abnormal_tail_pigmentation1.00830731
78MP0003315_abnormal_perineum_morphology0.99347589
79MP0010155_abnormal_intestine_physiology0.99013117
80MP0002452_abnormal_antigen_presenting0.98787071
81MP0005501_abnormal_skin_physiology0.96168811
82MP0002166_altered_tumor_susceptibility0.95634136
83MP0003866_abnormal_defecation0.95430141
84MP0008260_abnormal_autophagy0.95384243
85MP0002653_abnormal_ependyma_morphology0.93380560
86MP0005058_abnormal_lysosome_morphology0.93185902
87MP0000477_abnormal_intestine_morphology0.93015388
88MP0001873_stomach_inflammation0.92501591
89MP0002723_abnormal_immune_serum0.92416937
90MP0003436_decreased_susceptibility_to0.92249946
91MP0005076_abnormal_cell_differentiation0.90419844
92MP0000049_abnormal_middle_ear0.89964291
93MP0003186_abnormal_redox_activity0.89186574
94MP0000358_abnormal_cell_content/0.88143307
95MP0005025_abnormal_response_to0.88025730
96MP0002277_abnormal_respiratory_mucosa0.86324338
97MP0001881_abnormal_mammary_gland0.85837773
98MP0004133_heterotaxia0.85615472
99MP0000681_abnormal_thyroid_gland0.84736847
100MP0009785_altered_susceptibility_to0.84232809
101MP0003566_abnormal_cell_adhesion0.82446034
102MP0003941_abnormal_skin_development0.81674401
103MP0005000_abnormal_immune_tolerance0.80574185
104MP0003718_maternal_effect0.79989056
105MP0003705_abnormal_hypodermis_morpholog0.79151387
106MP0002006_tumorigenesis0.77930677
107MP0003119_abnormal_digestive_system0.77052227
108MP0009672_abnormal_birth_weight0.76856097
109MP0001849_ear_inflammation0.76552048
110MP0003938_abnormal_ear_development0.76077180
111MP0002095_abnormal_skin_pigmentation0.75929476
112MP0002111_abnormal_tail_morphology0.74742088
113MP0005666_abnormal_adipose_tissue0.67642069
114MP0005464_abnormal_platelet_physiology0.67425915
115MP0002932_abnormal_joint_morphology0.66417432
116MP0002697_abnormal_eye_size0.65596893
117MP0004947_skin_inflammation0.65500421
118MP0002938_white_spotting0.65294693
119MP0002098_abnormal_vibrissa_morphology0.65276025
120MP0009053_abnormal_anal_canal0.65109927
121MP0002210_abnormal_sex_determination0.64682807
122MP0009931_abnormal_skin_appearance0.63194280
123MP0001915_intracranial_hemorrhage0.63133790
124MP0001145_abnormal_male_reproductive0.62945626
125MP0001216_abnormal_epidermal_layer0.62598374
126MP0005384_cellular_phenotype0.60676861
127MP0000750_abnormal_muscle_regeneration0.60664761
128MP0003448_altered_tumor_morphology0.59351070

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.68209342
2Abnormal number of erythroid precursors (HP:0012131)7.09991833
3Reticulocytopenia (HP:0001896)6.87364381
4Macrocytic anemia (HP:0001972)4.93118940
5Pallor (HP:0000980)4.76552011
6Microvesicular hepatic steatosis (HP:0001414)4.02517033
7Colon cancer (HP:0003003)3.79590240
8Abnormal mitochondria in muscle tissue (HP:0008316)3.67739422
9Aplastic anemia (HP:0001915)3.66626491
10Thrombocytosis (HP:0001894)3.64587195
11Mitochondrial inheritance (HP:0001427)3.47723596
12Hepatocellular necrosis (HP:0001404)3.45368767
13Increased intramyocellular lipid droplets (HP:0012240)3.43500274
14Acute necrotizing encephalopathy (HP:0006965)3.41029591
15Oral leukoplakia (HP:0002745)3.30843765
16Increased muscle lipid content (HP:0009058)3.20703128
17Birth length less than 3rd percentile (HP:0003561)3.20536166
18Selective tooth agenesis (HP:0001592)3.17947748
19Aplasia/Hypoplasia of the sacrum (HP:0008517)3.06470042
2011 pairs of ribs (HP:0000878)3.06008299
21Hepatic necrosis (HP:0002605)3.05285039
22Increased hepatocellular lipid droplets (HP:0006565)3.04221510
23Acute encephalopathy (HP:0006846)3.03123795
24Increased CSF lactate (HP:0002490)2.94544127
25Respiratory difficulties (HP:0002880)2.85945110
26Absent thumb (HP:0009777)2.85895027
27Multiple enchondromatosis (HP:0005701)2.85411982
28Trismus (HP:0000211)2.85299086
29Broad distal phalanx of finger (HP:0009836)2.82350463
30Abnormality of reticulocytes (HP:0004312)2.79988987
31Breast hypoplasia (HP:0003187)2.79273128
32Lipid accumulation in hepatocytes (HP:0006561)2.74533142
33Rough bone trabeculation (HP:0100670)2.70228088
34IgM deficiency (HP:0002850)2.61469658
35Agammaglobulinemia (HP:0004432)2.60726512
36Microretrognathia (HP:0000308)2.60049005
37Ragged-red muscle fibers (HP:0003200)2.51143649
38Partial duplication of thumb phalanx (HP:0009944)2.47930944
39Basal cell carcinoma (HP:0002671)2.45649616
40Exercise intolerance (HP:0003546)2.44312350
41Carpal bone hypoplasia (HP:0001498)2.43261000
42Medulloblastoma (HP:0002885)2.41709568
43Panhypogammaglobulinemia (HP:0003139)2.40777011
44Seborrheic dermatitis (HP:0001051)2.40544534
45Progressive macrocephaly (HP:0004481)2.39331077
46Renal Fanconi syndrome (HP:0001994)2.34933279
47Cerebral edema (HP:0002181)2.33419481
48Neoplasm of the pancreas (HP:0002894)2.33321936
49Testicular atrophy (HP:0000029)2.33261590
50Ependymoma (HP:0002888)2.32034181
51Lactic acidosis (HP:0003128)2.30246041
52Myelodysplasia (HP:0002863)2.29547860
53Hypertensive crisis (HP:0100735)2.29462802
54Partial duplication of the phalanx of hand (HP:0009999)2.28958283
55Patellar aplasia (HP:0006443)2.27774662
56Petechiae (HP:0000967)2.23833871
57Increased serum lactate (HP:0002151)2.23164840
58Missing ribs (HP:0000921)2.22089411
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.20569317
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.20569317
61Asplenia (HP:0001746)2.20395118
62Abnormal number of incisors (HP:0011064)2.17419231
63Aplasia/Hypoplasia of the patella (HP:0006498)2.16178612
64Abnormality of the anterior horn cell (HP:0006802)2.15210076
65Degeneration of anterior horn cells (HP:0002398)2.15210076
66Premature graying of hair (HP:0002216)2.10308625
67Premature skin wrinkling (HP:0100678)2.09111975
68Depressed nasal ridge (HP:0000457)2.07799925
69Colitis (HP:0002583)2.03754111
70Aplasia/Hypoplasia of the spleen (HP:0010451)2.02826451
71Truncus arteriosus (HP:0001660)2.02628798
72Poikiloderma (HP:0001029)2.02289387
73Abnormality of the heme biosynthetic pathway (HP:0010472)2.00880661
74Lymphoma (HP:0002665)2.00388064
75Atresia of the external auditory canal (HP:0000413)2.00362054
76Cerebral hypomyelination (HP:0006808)1.98348758
77Cellular immunodeficiency (HP:0005374)1.97559283
78Elevated erythrocyte sedimentation rate (HP:0003565)1.96828705
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96213679
80Abnormality of the preputium (HP:0100587)1.95628536
81Amaurosis fugax (HP:0100576)1.95153592
82Pancytopenia (HP:0001876)1.94385198
83Stenosis of the external auditory canal (HP:0000402)1.93984525
84Glossoptosis (HP:0000162)1.93711865
853-Methylglutaconic aciduria (HP:0003535)1.93388165
86Premature ovarian failure (HP:0008209)1.92864510
87Triphalangeal thumb (HP:0001199)1.92294176
88Hypoplasia of the radius (HP:0002984)1.90653042
89Meckel diverticulum (HP:0002245)1.89564546
90Agnosia (HP:0010524)1.89411300
91Villous atrophy (HP:0011473)1.89284099
92Abnormality of small intestinal villus morphology (HP:0011472)1.89284099
93Increased IgE level (HP:0003212)1.88912276
94Duplication of thumb phalanx (HP:0009942)1.88649940
95Chronic otitis media (HP:0000389)1.87578997
96Abnormal trabecular bone morphology (HP:0100671)1.86583762
97Tracheoesophageal fistula (HP:0002575)1.86536393
98Squamous cell carcinoma (HP:0002860)1.85614908
99Bone marrow hypocellularity (HP:0005528)1.85414098
100Cholecystitis (HP:0001082)1.83600204
101Abnormal gallbladder physiology (HP:0012438)1.83600204
102Abnormality of the parietal bone (HP:0002696)1.83213072
103Obstructive lung disease (HP:0006536)1.82837151
104Chronic obstructive pulmonary disease (HP:0006510)1.82837151
105Abnormality of the ileum (HP:0001549)1.81879747
106Cleft eyelid (HP:0000625)1.81876253
107Abnormality of T cell physiology (HP:0011840)1.81830564
108Respiratory failure (HP:0002878)1.81760547
109Chromsome breakage (HP:0040012)1.81024181
110Thick lower lip vermilion (HP:0000179)1.80923263
111Gastrointestinal inflammation (HP:0004386)1.79782519
112Progressive muscle weakness (HP:0003323)1.79415714
113Abnormality of T cells (HP:0002843)1.79345138
114Myopathic facies (HP:0002058)1.79078676
115Proximal placement of thumb (HP:0009623)1.77562352
116Abnormal hemoglobin (HP:0011902)1.77511579
117Emotional lability (HP:0000712)1.74196945
118Horseshoe kidney (HP:0000085)1.74016393
119Cellulitis (HP:0100658)1.73421555
120Migraine (HP:0002076)1.73144946
121Absent radius (HP:0003974)1.71893080
122Abnormality of chromosome stability (HP:0003220)1.69863723
123Sparse eyelashes (HP:0000653)1.69090520
124Secondary amenorrhea (HP:0000869)1.67237373
125Type I transferrin isoform profile (HP:0003642)1.67154177
126Deviation of the thumb (HP:0009603)1.66637694
127Optic nerve coloboma (HP:0000588)1.66029030
128Duodenal stenosis (HP:0100867)1.64530320
129Small intestinal stenosis (HP:0012848)1.64530320
130Recurrent bronchitis (HP:0002837)1.63230754
131Nasolacrimal duct obstruction (HP:0000579)1.63082952
132Gastrointestinal stroma tumor (HP:0100723)1.61997353
133Chromosomal breakage induced by crosslinking agents (HP:0003221)1.61934301
134Acute lymphatic leukemia (HP:0006721)1.60338876
135Neoplasm of the colon (HP:0100273)1.60030018
136Recurrent viral infections (HP:0004429)1.58888003
137Rhabdomyosarcoma (HP:0002859)1.58602182
138Slender long bone (HP:0003100)1.58433866
139High anterior hairline (HP:0009890)1.58100604
140Deep palmar crease (HP:0006191)1.56827353
141Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.56133085
142Absent forearm bone (HP:0003953)1.55671939
143Aplasia involving forearm bones (HP:0009822)1.55671939
144Reticulocytosis (HP:0001923)1.55492322
145Muscle fiber atrophy (HP:0100295)1.54915708
146Neutropenia (HP:0001875)1.54827946
147Angiofibromas (HP:0010615)1.54642967
148Adenoma sebaceum (HP:0009720)1.54642967
149Abnormality of DNA repair (HP:0003254)1.54537169
150Aplasia/Hypoplasia of the thymus (HP:0010515)1.54414414
151Aplasia/Hypoplasia of the uvula (HP:0010293)1.54399058
152Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.54059166
153Abnormality of glycolysis (HP:0004366)1.53818428
154Abnormality of the umbilical cord (HP:0010881)1.52965718
155Exertional dyspnea (HP:0002875)1.52816438
156Preauricular skin tag (HP:0000384)1.52117694
157Abnormality of dicarboxylic acid metabolism (HP:0010995)1.51959604
158Dicarboxylic aciduria (HP:0003215)1.51959604
159Abnormal glycosylation (HP:0012345)1.51954767

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.91258678
2NME23.89704698
3BUB13.84274358
4SMG13.68290609
5WEE13.43247728
6EEF2K3.04288729
7CDC72.62207442
8RPS6KB22.48269584
9MAP4K12.22633925
10NEK22.13561680
11MAP3K102.07146469
12EIF2AK12.05121397
13PRPF4B2.03483541
14TESK22.00586000
15LRRK21.99436253
16STK161.94538526
17PASK1.93788167
18TLK11.91199193
19DYRK31.90637613
20TGFBR11.80899727
21PIM21.79398254
22RPS6KA41.66900006
23SRPK11.64390201
24PKN21.59278347
25VRK11.58888451
26TSSK61.57359770
27CDK71.57241713
28ARAF1.56679574
29FLT31.52333410
30KDR1.47577675
31ACVR1B1.47011062
32STK101.43114205
33SCYL21.42009865
34PAK41.41318779
35EIF2AK31.40977246
36IRAK31.39205790
37AURKB1.38325907
38EPHA21.36185535
39MAP3K81.35720567
40BRSK21.33618111
41TTK1.32040132
42MAPKAPK31.26356927
43TAF11.24861939
44CDK191.24340360
45PLK11.23484456
46CDK41.22002073
47ATR1.21820099
48BTK1.11557214
49MKNK11.11181353
50PLK41.09726514
51MAP2K31.08536185
52PIM11.07521819
53SIK11.04754019
54ZAP701.04483554
55BRAF1.02499015
56TAOK21.02383139
57ILK1.00953103
58ICK1.00114764
59MAP3K111.00099561
60PBK0.96361646
61TRIB30.94624374
62NEK10.93697988
63AURKA0.92575737
64STK40.91314331
65TESK10.83138786
66ZAK0.82117431
67GRK60.81788278
68CHEK10.79329952
69CDK120.78068966
70CHEK20.77916167
71IRAK40.76834570
72TYK20.73555567
73KIT0.73327868
74TEC0.73325026
75BCKDK0.71416648
76JAK30.71111336
77MST40.70842340
78PAK10.68775923
79BLK0.67907504
80CSNK2A20.67826474
81RPS6KA50.67760407
82MAP2K20.67181662
83BRSK10.64254683
84ERN10.62112717
85IKBKB0.61551583
86DYRK20.61480011
87ABL20.60962456
88DAPK10.60903772
89CSF1R0.58408938
90IRAK20.56778084
91PRKCI0.56481383
92CSNK2A10.54598011
93CDK20.54370618
94CLK10.53320850
95MKNK20.53113763
96DYRK1B0.52910717
97MAP3K30.52831098
98PAK20.52417721
99PTK60.52045782
100CDK60.51899760
101FES0.50045734
102ALK0.49685231
103CDK80.49635075
104MAPK110.48652970
105NLK0.48292487
106MUSK0.48004104
107ATM0.47696840
108HIPK20.46081779
109MAPKAPK50.44187177
110TBK10.44137680
111CDK90.43274348
112PLK30.43233717
113AKT20.40286465
114BMX0.39333819
115NME10.38706714
116IKBKE0.38504117
117DAPK30.38209521
118MAP3K130.37655853
119LCK0.36757437
120MAPKAPK20.36120675
121RPS6KA60.35491916
122MTOR0.35164849
123SYK0.34802346
124BRD40.34473851
125RPS6KL10.34320827
126RPS6KC10.34320827
127TNK20.33463848
128LYN0.31663191
129RPS6KA10.30651365
130CDK11A0.29279682
131ITK0.27558852

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030106.02002318
2DNA replication_Homo sapiens_hsa030304.56105827
3Mismatch repair_Homo sapiens_hsa034303.76009777
4Spliceosome_Homo sapiens_hsa030403.19756330
5Proteasome_Homo sapiens_hsa030503.10382819
6RNA polymerase_Homo sapiens_hsa030203.03180395
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.91418348
8Base excision repair_Homo sapiens_hsa034102.78853267
9RNA transport_Homo sapiens_hsa030132.54899485
10Nucleotide excision repair_Homo sapiens_hsa034202.54436196
11Homologous recombination_Homo sapiens_hsa034402.51656409
12Pyrimidine metabolism_Homo sapiens_hsa002402.40370610
13One carbon pool by folate_Homo sapiens_hsa006702.24032233
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17558786
15Cell cycle_Homo sapiens_hsa041102.02229741
16Non-homologous end-joining_Homo sapiens_hsa034501.62069156
17Fanconi anemia pathway_Homo sapiens_hsa034601.59071281
18RNA degradation_Homo sapiens_hsa030181.57325856
19p53 signaling pathway_Homo sapiens_hsa041151.45702782
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38524805
21Basal transcription factors_Homo sapiens_hsa030221.33223888
22mRNA surveillance pathway_Homo sapiens_hsa030151.24042114
23Primary immunodeficiency_Homo sapiens_hsa053401.23389133
24Sulfur relay system_Homo sapiens_hsa041221.16087524
25Antigen processing and presentation_Homo sapiens_hsa046121.15358301
26Epstein-Barr virus infection_Homo sapiens_hsa051691.12733866
27Systemic lupus erythematosus_Homo sapiens_hsa053221.12122733
28Purine metabolism_Homo sapiens_hsa002301.10234747
29Protein export_Homo sapiens_hsa030601.01615337
30Herpes simplex infection_Homo sapiens_hsa051681.00111667
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97268330
32Pentose phosphate pathway_Homo sapiens_hsa000300.96414781
33Folate biosynthesis_Homo sapiens_hsa007900.96097874
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90172325
35Cyanoamino acid metabolism_Homo sapiens_hsa004600.89813060
36Viral carcinogenesis_Homo sapiens_hsa052030.88508444
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84156189
38Parkinsons disease_Homo sapiens_hsa050120.81331456
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80301451
40HTLV-I infection_Homo sapiens_hsa051660.78839506
41Cardiac muscle contraction_Homo sapiens_hsa042600.76783639
42Huntingtons disease_Homo sapiens_hsa050160.75378199
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73884827
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.68785799
45Small cell lung cancer_Homo sapiens_hsa052220.68701377
46Thyroid cancer_Homo sapiens_hsa052160.68326130
47Autoimmune thyroid disease_Homo sapiens_hsa053200.66222238
48Legionellosis_Homo sapiens_hsa051340.65288150
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62709792
50Biosynthesis of amino acids_Homo sapiens_hsa012300.62606053
51Measles_Homo sapiens_hsa051620.62260415
52Apoptosis_Homo sapiens_hsa042100.61941847
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.60214535
54Oxidative phosphorylation_Homo sapiens_hsa001900.59161996
55Fatty acid elongation_Homo sapiens_hsa000620.59158509
56Acute myeloid leukemia_Homo sapiens_hsa052210.59007149
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.58754136
58Hematopoietic cell lineage_Homo sapiens_hsa046400.58367059
59Glutathione metabolism_Homo sapiens_hsa004800.57876935
60Non-small cell lung cancer_Homo sapiens_hsa052230.57781674
61Selenocompound metabolism_Homo sapiens_hsa004500.56483293
62Notch signaling pathway_Homo sapiens_hsa043300.55545911
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54562964
64Shigellosis_Homo sapiens_hsa051310.54101137
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52780334
66N-Glycan biosynthesis_Homo sapiens_hsa005100.52519573
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51212856
68Chronic myeloid leukemia_Homo sapiens_hsa052200.49689796
69Graft-versus-host disease_Homo sapiens_hsa053320.48535014
70Basal cell carcinoma_Homo sapiens_hsa052170.46255774
71MicroRNAs in cancer_Homo sapiens_hsa052060.44968069
72Bladder cancer_Homo sapiens_hsa052190.44899295
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.44089469
74Hepatitis B_Homo sapiens_hsa051610.42371667
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42208743
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40901827
77Pyruvate metabolism_Homo sapiens_hsa006200.40529589
78Pancreatic cancer_Homo sapiens_hsa052120.38739713
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37726168
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37390591
81B cell receptor signaling pathway_Homo sapiens_hsa046620.36976955
82Leishmaniasis_Homo sapiens_hsa051400.36601919
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35938205
84Colorectal cancer_Homo sapiens_hsa052100.34752270
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.33657623
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32046961
87Carbon metabolism_Homo sapiens_hsa012000.31663249
88Galactose metabolism_Homo sapiens_hsa000520.31247977
89Phenylalanine metabolism_Homo sapiens_hsa003600.30888742
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30708439
91HIF-1 signaling pathway_Homo sapiens_hsa040660.30608628
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30249796
93Pathways in cancer_Homo sapiens_hsa052000.29602299
94Influenza A_Homo sapiens_hsa051640.29584359
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.28798549
96Alcoholism_Homo sapiens_hsa050340.28439482
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27996455
98Viral myocarditis_Homo sapiens_hsa054160.27915207
99T cell receptor signaling pathway_Homo sapiens_hsa046600.27767353
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.25998172
101Fructose and mannose metabolism_Homo sapiens_hsa000510.25620297
102TGF-beta signaling pathway_Homo sapiens_hsa043500.25330294
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24915600
104Oocyte meiosis_Homo sapiens_hsa041140.24678435
105VEGF signaling pathway_Homo sapiens_hsa043700.24587360
106Alzheimers disease_Homo sapiens_hsa050100.24208007
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24069459
108Toxoplasmosis_Homo sapiens_hsa051450.23650783
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23198832
110Other glycan degradation_Homo sapiens_hsa005110.22930553
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22613920
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22202499
113Allograft rejection_Homo sapiens_hsa053300.21796403
114Hippo signaling pathway_Homo sapiens_hsa043900.20896625
115Asthma_Homo sapiens_hsa053100.20135793
116Renin-angiotensin system_Homo sapiens_hsa046140.20118015
117Tyrosine metabolism_Homo sapiens_hsa003500.19791049
118Metabolic pathways_Homo sapiens_hsa011000.19004185
119Vibrio cholerae infection_Homo sapiens_hsa051100.17903447
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16722527

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