RPL18A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* viral transcription (GO:0019083)9.46644241
2* translational termination (GO:0006415)9.07267807
3ribosomal small subunit biogenesis (GO:0042274)8.37657944
4* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.72555406
5* translational elongation (GO:0006414)7.71834201
6* cotranslational protein targeting to membrane (GO:0006613)7.57334232
7* protein targeting to ER (GO:0045047)7.55107211
8maturation of SSU-rRNA (GO:0030490)7.42785256
9* establishment of protein localization to endoplasmic reticulum (GO:0072599)7.19544845
10* protein localization to endoplasmic reticulum (GO:0070972)7.09030536
11* viral life cycle (GO:0019058)6.99601738
12* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.98588020
13* cellular protein complex disassembly (GO:0043624)6.95439640
14* translational initiation (GO:0006413)6.52399018
15ribosomal large subunit biogenesis (GO:0042273)6.14936047
16* protein complex disassembly (GO:0043241)6.10345637
17* macromolecular complex disassembly (GO:0032984)5.72247450
18* nuclear-transcribed mRNA catabolic process (GO:0000956)5.07841627
19ATP synthesis coupled proton transport (GO:0015986)5.03354647
20energy coupled proton transport, down electrochemical gradient (GO:0015985)5.03354647
21* protein targeting to membrane (GO:0006612)4.97463659
22DNA deamination (GO:0045006)4.92081143
23* mRNA catabolic process (GO:0006402)4.85489295
24ribonucleoprotein complex biogenesis (GO:0022613)4.70380918
25* translation (GO:0006412)4.69870596
26* RNA catabolic process (GO:0006401)4.51490550
27establishment of protein localization to mitochondrial membrane (GO:0090151)4.02472599
28chaperone-mediated protein transport (GO:0072321)3.84768735
29respiratory electron transport chain (GO:0022904)3.84060195
30oxidative phosphorylation (GO:0006119)3.82573288
31telomere maintenance via semi-conservative replication (GO:0032201)3.75665076
32electron transport chain (GO:0022900)3.74993834
33rRNA processing (GO:0006364)3.73942406
34formation of translation preinitiation complex (GO:0001731)3.72117959
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.70256952
36cellular component biogenesis (GO:0044085)3.67255931
37DNA strand elongation involved in DNA replication (GO:0006271)3.65038691
38rRNA metabolic process (GO:0016072)3.59726362
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.55606417
40regulation of mitochondrial translation (GO:0070129)3.55349369
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.55340814
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.55340814
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.55340814
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.54471068
45signal transduction involved in DNA damage checkpoint (GO:0072422)3.53174640
46signal transduction involved in DNA integrity checkpoint (GO:0072401)3.53174640
47DNA strand elongation (GO:0022616)3.50620960
48signal transduction involved in cell cycle checkpoint (GO:0072395)3.44829716
49protein complex biogenesis (GO:0070271)3.41725389
50pseudouridine synthesis (GO:0001522)3.39195460
51purine deoxyribonucleotide catabolic process (GO:0009155)3.35866483
52anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.34508815
53base-excision repair, AP site formation (GO:0006285)3.33206922
54* establishment of protein localization to membrane (GO:0090150)3.31961028
55mitochondrial respiratory chain complex assembly (GO:0033108)3.31815711
56deoxyribonucleotide catabolic process (GO:0009264)3.30226318
57NADH dehydrogenase complex assembly (GO:0010257)3.25483450
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.25483450
59mitochondrial respiratory chain complex I assembly (GO:0032981)3.25483450
60regulation of cellular amino acid metabolic process (GO:0006521)3.24527695
61telomere maintenance via recombination (GO:0000722)3.22752882
62deoxyribose phosphate catabolic process (GO:0046386)3.21869220
63ncRNA 3-end processing (GO:0043628)3.16891824
64negative regulation of B cell apoptotic process (GO:0002903)3.14364712
65protein targeting to mitochondrion (GO:0006626)3.11752182
66deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.11703513
67* protein targeting (GO:0006605)3.08957513
68guanosine-containing compound biosynthetic process (GO:1901070)3.05723128
69positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05085259
70* establishment of protein localization to organelle (GO:0072594)3.04950134
71deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.00929956
72platelet dense granule organization (GO:0060155)3.00670752
73inner mitochondrial membrane organization (GO:0007007)2.99668850
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97309167
75termination of RNA polymerase III transcription (GO:0006386)2.95702617
76transcription elongation from RNA polymerase III promoter (GO:0006385)2.95702617
77telomere maintenance via telomere lengthening (GO:0010833)2.95206273
78DNA replication initiation (GO:0006270)2.95181980
79response to interferon-beta (GO:0035456)2.94612706
80pyrimidine nucleotide catabolic process (GO:0006244)2.94455018
81mitotic recombination (GO:0006312)2.93377213
82purine nucleoside triphosphate biosynthetic process (GO:0009145)2.93373165
83positive regulation of ligase activity (GO:0051351)2.93288775
84purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.93258525
85establishment of protein localization to mitochondrion (GO:0072655)2.92911823
86peptidyl-arginine omega-N-methylation (GO:0035247)2.90929393
87ATP biosynthetic process (GO:0006754)2.89557837
88pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.87311594
89definitive hemopoiesis (GO:0060216)2.86056525
90proteasome assembly (GO:0043248)2.84906465
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.82641432
92spliceosomal snRNP assembly (GO:0000387)2.81855139
93ribosome biogenesis (GO:0042254)2.77158449
94nucleotide-excision repair, DNA gap filling (GO:0006297)2.77109827
95spliceosomal complex assembly (GO:0000245)2.77025755
96DNA unwinding involved in DNA replication (GO:0006268)2.74959192
97ncRNA processing (GO:0034470)2.70388137
98negative regulation of RNA splicing (GO:0033119)2.65396396
99CENP-A containing nucleosome assembly (GO:0034080)2.60885604
100establishment of integrated proviral latency (GO:0075713)2.59232392
101respiratory chain complex IV assembly (GO:0008535)2.58004073
102histone mRNA metabolic process (GO:0008334)2.56497138
103* protein localization to membrane (GO:0072657)2.55283278
104chromatin remodeling at centromere (GO:0031055)2.55204535
105transcription-coupled nucleotide-excision repair (GO:0006283)2.53314246
106regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.48781095
107negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.47503342
108ncRNA metabolic process (GO:0034660)2.45020111
109viral mRNA export from host cell nucleus (GO:0046784)2.44214972
110DNA replication checkpoint (GO:0000076)2.44043746
111antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.42285456
112antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.42285456
113* gene expression (GO:0010467)2.40218812
114positive regulation of respiratory burst (GO:0060267)2.39699051
115nucleobase biosynthetic process (GO:0046112)2.38851922
116antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.37054981
117lymphoid progenitor cell differentiation (GO:0002320)2.36807359
118* cellular component disassembly (GO:0022411)2.36761813
119rRNA modification (GO:0000154)2.33840991
120pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.33557734
121GTP biosynthetic process (GO:0006183)2.32499211
122DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.32326239
123antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.31771057
124tRNA methylation (GO:0030488)2.31261340
125ribonucleoprotein complex assembly (GO:0022618)2.30250396
126kinetochore organization (GO:0051383)2.29739005
127negative regulation of ligase activity (GO:0051352)2.29528927
128negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.29528927
129pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.29330246
130mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.28686684
131intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.27935861
132signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.27935861
133CTP metabolic process (GO:0046036)2.27597811
134CTP biosynthetic process (GO:0006241)2.27597811
135antigen processing and presentation via MHC class Ib (GO:0002475)2.27235044
136UTP biosynthetic process (GO:0006228)2.26480366
137regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.24827868
138metallo-sulfur cluster assembly (GO:0031163)2.24672697
139iron-sulfur cluster assembly (GO:0016226)2.24672697
140DNA replication-independent nucleosome organization (GO:0034724)2.24318669
141DNA replication-independent nucleosome assembly (GO:0006336)2.24318669
142ribosomal small subunit assembly (GO:0000028)10.3382300

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.81498649
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.45515036
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.14236281
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.93213387
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.13414812
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09278843
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.03329022
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.87224297
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.85373534
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85257884
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74293663
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72144565
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64676677
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59062494
15XRN2_22483619_ChIP-Seq_HELA_Human2.57484226
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54364906
17* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.53863067
18TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.47648629
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.41691445
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40799444
21VDR_23849224_ChIP-Seq_CD4+_Human2.36339799
22* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33223981
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26727824
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.13884114
25TTF2_22483619_ChIP-Seq_HELA_Human2.13515457
26FOXP3_21729870_ChIP-Seq_TREG_Human2.13240089
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06233706
28DCP1A_22483619_ChIP-Seq_HELA_Human1.99774907
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.97314728
30* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.96992667
31* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95359304
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.94351665
33SCL_19346495_ChIP-Seq_HPC-7_Human1.93640578
34MYC_22102868_ChIP-Seq_BL_Human1.91885734
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91134453
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90720829
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87831252
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.86525735
39ERG_20887958_ChIP-Seq_HPC-7_Mouse1.80962103
40* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79462960
41VDR_21846776_ChIP-Seq_THP-1_Human1.75945213
42ELK1_19687146_ChIP-ChIP_HELA_Human1.75777241
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73783243
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.69632580
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.68462129
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65346014
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64634254
48* GABP_19822575_ChIP-Seq_HepG2_Human1.63527785
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.62546750
50* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61010729
51CIITA_25753668_ChIP-Seq_RAJI_Human1.60542799
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58112540
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.57855909
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57676451
55* SPI1_23547873_ChIP-Seq_NB4_Human1.55011678
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48979359
57* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.47484637
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.43269134
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.41316521
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37769224
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37373906
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37294620
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35383028
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33104425
65* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31056476
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28652396
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.28239222
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.26677169
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23251269
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19239848
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18850193
72MYC_18940864_ChIP-ChIP_HL60_Human1.18589277
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.18548151
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18251337
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16592008
76* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16400766
77BP1_19119308_ChIP-ChIP_Hs578T_Human1.15718827
78PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14571510
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12965405
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11584026
81VDR_24763502_ChIP-Seq_THP-1_Human1.11543390
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11048738
83MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10402712
84MAF_26560356_Chip-Seq_TH1_Human1.10016813
85* FOXP1_21924763_ChIP-Seq_HESCs_Human1.09276046
86* TET1_21451524_ChIP-Seq_MESCs_Mouse1.08998104
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07068609
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.06434508
89UTX_26944678_Chip-Seq_JUKART_Human1.06400634
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05384149
91RUNX1_22412390_ChIP-Seq_EML_Mouse1.04689759
92KDM5A_27292631_Chip-Seq_BREAST_Human1.02868562
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.02050540
94* CTCF_26484167_Chip-Seq_Bcells_Mouse1.01662229
95MAF_26560356_Chip-Seq_TH2_Human1.01187944
96MYB_26560356_Chip-Seq_TH2_Human0.99553952
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99408319
98RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99400244
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99199402
100GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99012557
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98421508
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95271385
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94449464
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94294939
105MYB_26560356_Chip-Seq_TH1_Human0.93750614
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92772462
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92451844
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92097034
109PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91648637
110SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90890177
111YY1_22570637_ChIP-Seq_MALME-3M_Human0.90549939
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90325565
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89570761
114* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89550813
115* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89125976
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88388163
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87912603
118BCL6_27268052_Chip-Seq_Bcells_Human0.87580413
119OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85225558
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85163369
121P68_20966046_ChIP-Seq_HELA_Human0.84549237
122HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84508771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.46853879
2MP0003693_abnormal_embryo_hatching3.45559353
3MP0002396_abnormal_hematopoietic_system3.31084049
4MP0004957_abnormal_blastocyst_morpholog2.64394760
5MP0010030_abnormal_orbit_morphology2.55597368
6MP0010094_abnormal_chromosome_stability2.52372277
7MP0001835_abnormal_antigen_presentation2.46681239
8MP0003763_abnormal_thymus_physiology2.43524596
9MP0003806_abnormal_nucleotide_metabolis2.43053433
10MP0003077_abnormal_cell_cycle2.36892366
11MP0005174_abnormal_tail_pigmentation2.33564642
12MP0000490_abnormal_crypts_of2.25378423
13MP0000685_abnormal_immune_system2.22264599
14MP0004808_abnormal_hematopoietic_stem2.22015053
15MP0008007_abnormal_cellular_replicative2.18847385
16MP0008058_abnormal_DNA_repair2.12479628
17MP0005671_abnormal_response_to2.05970911
18MP0005397_hematopoietic_system_phenotyp2.05605615
19MP0001545_abnormal_hematopoietic_system2.05605615
20MP0003111_abnormal_nucleus_morphology2.05572632
21MP0008057_abnormal_DNA_replication2.05024093
22MP0009333_abnormal_splenocyte_physiolog1.94142946
23MP0009785_altered_susceptibility_to1.91648967
24MP0005075_abnormal_melanosome_morpholog1.89326368
25MP0002398_abnormal_bone_marrow1.84719609
26MP0001800_abnormal_humoral_immune1.77692964
27MP0006035_abnormal_mitochondrial_morpho1.77381029
28MP0002132_abnormal_respiratory_system1.71404730
29MP0002095_abnormal_skin_pigmentation1.69805060
30MP0002148_abnormal_hypersensitivity_rea1.68393275
31MP0005025_abnormal_response_to1.66086684
32MP0002166_altered_tumor_susceptibility1.63883984
33MP0002420_abnormal_adaptive_immunity1.63282706
34MP0002722_abnormal_immune_system1.63135479
35MP0002452_abnormal_antigen_presenting1.61405140
36MP0001819_abnormal_immune_cell1.60197985
37MP0000689_abnormal_spleen_morphology1.59020537
38MP0003786_premature_aging1.58341930
39MP0001853_heart_inflammation1.56665747
40MP0006054_spinal_hemorrhage1.55847780
41MP0002723_abnormal_immune_serum1.54251007
42MP0000465_gastrointestinal_hemorrhage1.54155665
43MP0003718_maternal_effect1.53592451
44MP0010155_abnormal_intestine_physiology1.52235066
45MP0000716_abnormal_immune_system1.51691227
46MP0000703_abnormal_thymus_morphology1.51526699
47MP0002429_abnormal_blood_cell1.48841307
48MP0003724_increased_susceptibility_to1.47893250
49MP0005000_abnormal_immune_tolerance1.47085682
50MP0008932_abnormal_embryonic_tissue1.44237984
51MP0001873_stomach_inflammation1.41489354
52MP0003436_decreased_susceptibility_to1.38662696
53MP0003866_abnormal_defecation1.37598617
54MP0002006_tumorigenesis1.33308438
55MP0002019_abnormal_tumor_incidence1.29531702
56MP0002405_respiratory_system_inflammati1.28308060
57MP0005464_abnormal_platelet_physiology1.25897783
58MP0001790_abnormal_immune_system1.24213039
59MP0005387_immune_system_phenotype1.24213039
60MP0004381_abnormal_hair_follicle1.22856591
61MP0002234_abnormal_pharynx_morphology1.19098173
62MP0001764_abnormal_homeostasis1.17340585
63MP0000313_abnormal_cell_death1.16865286
64MP0009697_abnormal_copulation1.14223531
65MP0003567_abnormal_fetal_cardiomyocyte1.14069075
66MP0000858_altered_metastatic_potential1.13261476
67MP0000350_abnormal_cell_proliferation1.07298477
68MP0002938_white_spotting1.06745988
69MP0009278_abnormal_bone_marrow1.06414990
70MP0003315_abnormal_perineum_morphology1.06044444
71MP0003186_abnormal_redox_activity1.05399288
72MP0002419_abnormal_innate_immunity1.04176436
73MP0006292_abnormal_olfactory_placode1.04091473
74MP0002163_abnormal_gland_morphology1.03521751
75MP0000372_irregular_coat_pigmentation1.00422242
76MP0001986_abnormal_taste_sensitivity0.98557749
77MP0008789_abnormal_olfactory_epithelium0.96573371
78MP0000358_abnormal_cell_content/0.94548873
79MP0003011_delayed_dark_adaptation0.93996171
80MP0001881_abnormal_mammary_gland0.93984719
81MP0000678_abnormal_parathyroid_gland0.93951321
82MP0010352_gastrointestinal_tract_polyps0.91235797
83MP0003941_abnormal_skin_development0.88896106
84MP0001845_abnormal_inflammatory_respons0.87391542
85MP0008995_early_reproductive_senescence0.86646003
86MP0002796_impaired_skin_barrier0.85326842
87MP0000537_abnormal_urethra_morphology0.83971123
88MP0000613_abnormal_salivary_gland0.83394666
89MP0002933_joint_inflammation0.83258010
90MP0001145_abnormal_male_reproductive0.81763806
91MP0001346_abnormal_lacrimal_gland0.81038782
92MP0005409_darkened_coat_color0.80785566
93MP0002210_abnormal_sex_determination0.80579926
94MP0003123_paternal_imprinting0.79563469
95MP0001348_abnormal_lacrimal_gland0.78284603
96MP0003136_yellow_coat_color0.78148482
97MP0001663_abnormal_digestive_system0.76991710
98MP0000477_abnormal_intestine_morphology0.76101585
99MP0001730_embryonic_growth_arrest0.74966793
100MP0005380_embryogenesis_phenotype0.74182195
101MP0001672_abnormal_embryogenesis/_devel0.74182195
102MP0005084_abnormal_gallbladder_morpholo0.72302618
103MP0008873_increased_physiological_sensi0.72116618
104MP0000653_abnormal_sex_gland0.71611563
105MP0002080_prenatal_lethality0.71548559
106MP0000015_abnormal_ear_pigmentation0.71047937
107MP0003828_pulmonary_edema0.70497488
108MP0004147_increased_porphyrin_level0.69936543
109MP0001929_abnormal_gametogenesis0.69323229
110MP0002085_abnormal_embryonic_tissue0.68642088
111MP0001697_abnormal_embryo_size0.68624437
112MP0001119_abnormal_female_reproductive0.67597000
113MP0002160_abnormal_reproductive_system0.66885333
114MP0002277_abnormal_respiratory_mucosa0.66708187
115MP0004947_skin_inflammation0.66418896
116MP0003943_abnormal_hepatobiliary_system0.66252765
117MP0006036_abnormal_mitochondrial_physio0.66093184
118MP0002138_abnormal_hepatobiliary_system0.66081494
119MP0000049_abnormal_middle_ear0.64897215
120MP0005394_taste/olfaction_phenotype0.64453034
121MP0005499_abnormal_olfactory_system0.64453034
122MP0005023_abnormal_wound_healing0.64387662
123MP0002111_abnormal_tail_morphology0.63947340
124MP0005501_abnormal_skin_physiology0.62925512
125MP0008469_abnormal_protein_level0.61616388
126MP0002249_abnormal_larynx_morphology0.61406211
127MP0000470_abnormal_stomach_morphology0.58328922
128MP0001293_anophthalmia0.57257302
129MP0008004_abnormal_stomach_pH0.56127683

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)8.21202716
2Reticulocytopenia (HP:0001896)7.71800649
3Abnormal number of erythroid precursors (HP:0012131)7.65675233
4Macrocytic anemia (HP:0001972)5.59410965
5Pallor (HP:0000980)5.45125348
6Thrombocytosis (HP:0001894)5.13356780
7Aplastic anemia (HP:0001915)4.46072427
8Acute encephalopathy (HP:0006846)4.25663166
9Progressive macrocephaly (HP:0004481)3.79267012
10Aplasia/Hypoplasia of the sacrum (HP:0008517)3.78433384
11Colon cancer (HP:0003003)3.62279917
1211 pairs of ribs (HP:0000878)3.26570398
13Cerebral edema (HP:0002181)3.19665961
14Increased hepatocellular lipid droplets (HP:0006565)3.08464911
15Abnormal hemoglobin (HP:0011902)3.07514360
16IgM deficiency (HP:0002850)3.06651285
17Elevated erythrocyte sedimentation rate (HP:0003565)3.04749652
18Lactic acidosis (HP:0003128)3.00028590
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.97982852
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92946357
21Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92946357
22Exertional dyspnea (HP:0002875)2.89846169
23Hepatocellular necrosis (HP:0001404)2.78793674
24Oral leukoplakia (HP:0002745)2.78716998
25Petechiae (HP:0000967)2.72308324
26Absent thumb (HP:0009777)2.71432333
27Lipid accumulation in hepatocytes (HP:0006561)2.62904816
28Type I transferrin isoform profile (HP:0003642)2.61561926
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.61297687
30Mitochondrial inheritance (HP:0001427)2.54085077
31Respiratory failure (HP:0002878)2.51780776
32Chronic otitis media (HP:0000389)2.50689608
33Testicular atrophy (HP:0000029)2.48306454
34Abnormality of reticulocytes (HP:0004312)2.45790245
35Abnormality of the heme biosynthetic pathway (HP:0010472)2.44844038
36Poikiloderma (HP:0001029)2.43741123
37Prolonged bleeding time (HP:0003010)2.42376028
38Depressed nasal ridge (HP:0000457)2.42010975
39Increased intramyocellular lipid droplets (HP:0012240)2.40309920
403-Methylglutaconic aciduria (HP:0003535)2.39385775
41Congenital, generalized hypertrichosis (HP:0004540)2.38866530
42Myelodysplasia (HP:0002863)2.38046467
43Hepatic necrosis (HP:0002605)2.37937779
44Renal Fanconi syndrome (HP:0001994)2.37515588
45Asplenia (HP:0001746)2.37008167
46Recurrent bronchitis (HP:0002837)2.31677273
47Muscle fiber atrophy (HP:0100295)2.29426343
48Respiratory difficulties (HP:0002880)2.28582752
49Pancytopenia (HP:0001876)2.27643025
50Optic disc pallor (HP:0000543)2.22970175
51Migraine (HP:0002076)2.22701184
52Progressive muscle weakness (HP:0003323)2.18392693
53Increased CSF lactate (HP:0002490)2.17615622
54Myositis (HP:0100614)2.17295407
55Triphalangeal thumb (HP:0001199)2.14560530
56Aplasia/Hypoplasia of the spleen (HP:0010451)2.13572792
57Rough bone trabeculation (HP:0100670)2.11349298
58Leukodystrophy (HP:0002415)2.09514923
59Microretrognathia (HP:0000308)2.05964261
60Abnormality of T cell physiology (HP:0011840)2.04983468
61Lymphoma (HP:0002665)2.04361000
62Increased serum lactate (HP:0002151)2.03516464
63Abnormality of the preputium (HP:0100587)2.03043684
64Cellular immunodeficiency (HP:0005374)2.02555436
65Increased muscle lipid content (HP:0009058)2.01575587
66Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01131544
67Trismus (HP:0000211)2.00276826
68Panhypogammaglobulinemia (HP:0003139)2.00176661
69Lethargy (HP:0001254)2.00008797
70Thick lower lip vermilion (HP:0000179)1.99519213
71Type 2 muscle fiber atrophy (HP:0003554)1.98344773
72Hypoplasia of the radius (HP:0002984)1.95099068
73Reduced antithrombin III activity (HP:0001976)1.93275922
74Birth length less than 3rd percentile (HP:0003561)1.92193384
75Abnormality of the prostate (HP:0008775)1.92090084
76Partial duplication of thumb phalanx (HP:0009944)1.90864795
77Premature graying of hair (HP:0002216)1.90546151
78Agammaglobulinemia (HP:0004432)1.90153534
79Prostate neoplasm (HP:0100787)1.89540571
80Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89213315
81Dicarboxylic aciduria (HP:0003215)1.89213315
82IgG deficiency (HP:0004315)1.88570073
83Selective tooth agenesis (HP:0001592)1.88460128
84Emotional lability (HP:0000712)1.86488824
85Abnormality of T cells (HP:0002843)1.83598900
86Amaurosis fugax (HP:0100576)1.83077458
87Sparse eyelashes (HP:0000653)1.80607178
88Severe combined immunodeficiency (HP:0004430)1.80350721
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80323048
90Abnormal protein N-linked glycosylation (HP:0012347)1.80323048
91Abnormal protein glycosylation (HP:0012346)1.80323048
92Abnormal glycosylation (HP:0012345)1.80323048
93B lymphocytopenia (HP:0010976)1.80217462
94Acute necrotizing encephalopathy (HP:0006965)1.80033254
95Cleft eyelid (HP:0000625)1.79962502
96Partial duplication of the phalanx of hand (HP:0009999)1.79176226
97Acute lymphatic leukemia (HP:0006721)1.78954878
98Microvesicular hepatic steatosis (HP:0001414)1.78787798
99Neutropenia (HP:0001875)1.78290787
100Optic nerve coloboma (HP:0000588)1.77504384
101Abnormality of B cell number (HP:0010975)1.76676817
102Stenosis of the external auditory canal (HP:0000402)1.76179577
103Abnormal number of incisors (HP:0011064)1.75739612
104Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74895902
105Abnormal delayed hypersensitivity skin test (HP:0002963)1.74049604
106Multiple enchondromatosis (HP:0005701)1.72642214
107Chromsome breakage (HP:0040012)1.72057899
108Redundant skin (HP:0001582)1.71504347
109Seborrheic dermatitis (HP:0001051)1.70965358
110Horseshoe kidney (HP:0000085)1.70159964
111Cellulitis (HP:0100658)1.68739100
112Recurrent viral infections (HP:0004429)1.68302488
113Methylmalonic aciduria (HP:0012120)1.68229066
114Pulmonary fibrosis (HP:0002206)1.68010007
115Abnormality of cells of the lymphoid lineage (HP:0012140)1.67401861
116Recurrent abscess formation (HP:0002722)1.66898618
117Meningitis (HP:0001287)1.66885651
118Abnormal trabecular bone morphology (HP:0100671)1.66717337
119Carpal bone hypoplasia (HP:0001498)1.65868192
120Bone marrow hypocellularity (HP:0005528)1.65777588
121Abnormal mitochondria in muscle tissue (HP:0008316)1.65427271
122Abnormality of DNA repair (HP:0003254)1.64439793
123Lymphopenia (HP:0001888)1.64198527
124Abnormality of the ileum (HP:0001549)1.63514681
125Microcytic anemia (HP:0001935)1.63024043
126Degeneration of anterior horn cells (HP:0002398)1.62986412
127Abnormality of the anterior horn cell (HP:0006802)1.62986412
128Abnormality of the parietal bone (HP:0002696)1.62449037
129Exercise intolerance (HP:0003546)1.62177130
130Meckel diverticulum (HP:0002245)1.61714125
131Epistaxis (HP:0000421)1.60951625
132CNS demyelination (HP:0007305)1.59629784
133Abnormality of renal resorption (HP:0011038)1.58294631
134Squamous cell carcinoma (HP:0002860)1.58109520

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK27.20876950
2NME24.84665744
3SMG13.38593067
4TLK13.14561942
5TAF13.01214767
6STK162.73195053
7WEE12.69784126
8MAP4K12.60886110
9PIM22.42795990
10BUB12.39244842
11TGFBR12.37147027
12ZAK2.35063171
13RPS6KB22.21563269
14EEF2K2.16139065
15VRK12.06126644
16EIF2AK12.04656618
17CDK191.88423537
18LRRK21.87551218
19TEC1.82130095
20KIT1.81883531
21FLT31.80831513
22BTK1.75283802
23DYRK31.73321318
24SRPK11.72217379
25CDC71.56295658
26PBK1.56046318
27MKNK11.49628286
28RPS6KA41.49204763
29PASK1.44476355
30CDK71.39671051
31ACVR1B1.39161021
32BRSK21.26336200
33NEK21.26230985
34KDR1.24435503
35BLK1.23339878
36EIF2AK31.22855447
37IRAK41.21429766
38TXK1.21043614
39CDK81.20999127
40MUSK1.20279380
41IKBKB1.19345997
42IKBKE1.17548170
43TSSK61.15834045
44TBK11.15117516
45CHEK21.14883147
46AURKB1.14304018
47ILK1.12909747
48JAK31.12113006
49ZAP701.07340507
50NLK1.06534022
51PIM11.05183203
52MKNK21.03578784
53DAPK11.02271809
54MAP2K30.99122414
55TAOK30.96359595
56TTK0.96300953
57CSF1R0.95499153
58DYRK20.94477353
59ATR0.93535038
60MST40.92970216
61TGFBR20.90578556
62SYK0.89774284
63NME10.89245814
64MAP3K120.83533807
65PLK10.82828386
66TESK20.82507848
67MAP3K110.82363226
68MAPKAPK50.81857067
69PLK30.81449620
70STK100.81314874
71MAP3K100.78932315
72ITK0.77416875
73TYK20.75306370
74IRAK30.74883432
75MAP2K60.74368984
76TIE10.74317313
77MAPKAPK30.74184516
78RPS6KA50.73357302
79LYN0.72663066
80LCK0.70759798
81CDK40.70158135
82MATK0.69983930
83MYLK0.68243292
84CLK10.67972049
85ABL20.66248128
86TNIK0.66192926
87PAK40.65002959
88EIF2AK20.62976376
89MAP3K80.62732353
90CSNK2A20.60908700
91PLK40.59672048
92PKN20.59532441
93PRKG20.58543975
94CSNK1G30.57643902
95CSNK2A10.57128255
96ARAF0.55879434
97RPS6KA60.55513811
98AURKA0.54398692
99TNK20.51773328
100CDK90.51627231
101ADRBK20.51231135
102BCKDK0.50898518
103STK40.50571604
104RPS6KL10.50114856
105RPS6KC10.50114856
106CCNB10.49117127
107BMPR1B0.47802845
108MAP2K20.47737485
109NEK10.46080206
110GRK50.44278171
111CHEK10.41781384
112HIPK20.40713248
113TAOK20.40599154
114NEK90.39965009
115SCYL20.39727940
116NUAK10.39433303
117IRAK20.38951651
118MAPK40.38853394
119DAPK30.37926699
120BRSK10.37404767
121FES0.37359198
122GRK60.36447648
123BRAF0.36269310
124PRPF4B0.35655266
125MELK0.35561759
126TRIB30.33196882
127CSNK1G10.30919334
128PAK10.29716064
129CSNK1A1L0.28727958

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030107.42386931
2DNA replication_Homo sapiens_hsa030304.04217040
3Mismatch repair_Homo sapiens_hsa034303.29347034
4RNA polymerase_Homo sapiens_hsa030203.06836704
5Spliceosome_Homo sapiens_hsa030402.74203768
6Proteasome_Homo sapiens_hsa030502.72067405
7Homologous recombination_Homo sapiens_hsa034402.69779843
8Base excision repair_Homo sapiens_hsa034102.53968518
9Pyrimidine metabolism_Homo sapiens_hsa002402.34282252
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.31645761
11Nucleotide excision repair_Homo sapiens_hsa034202.30720421
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08131781
13Protein export_Homo sapiens_hsa030601.81796185
14RNA transport_Homo sapiens_hsa030131.77810561
15Primary immunodeficiency_Homo sapiens_hsa053401.75887756
16Fanconi anemia pathway_Homo sapiens_hsa034601.68770700
17Non-homologous end-joining_Homo sapiens_hsa034501.63704374
18RNA degradation_Homo sapiens_hsa030181.56960851
19Parkinsons disease_Homo sapiens_hsa050121.49657324
20Cell cycle_Homo sapiens_hsa041101.48032408
21One carbon pool by folate_Homo sapiens_hsa006701.45387862
22Basal transcription factors_Homo sapiens_hsa030221.36684020
23Oxidative phosphorylation_Homo sapiens_hsa001901.34355764
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25871077
25Antigen processing and presentation_Homo sapiens_hsa046121.22391898
26Purine metabolism_Homo sapiens_hsa002301.20727186
27Herpes simplex infection_Homo sapiens_hsa051681.15878029
28Huntingtons disease_Homo sapiens_hsa050161.15766486
29p53 signaling pathway_Homo sapiens_hsa041151.12663703
30Sulfur relay system_Homo sapiens_hsa041221.12086916
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01670414
32Hematopoietic cell lineage_Homo sapiens_hsa046401.00564139
33Folate biosynthesis_Homo sapiens_hsa007900.98579387
34Intestinal immune network for IgA production_Homo sapiens_hsa046720.98120620
35Biosynthesis of amino acids_Homo sapiens_hsa012300.97961034
36Epstein-Barr virus infection_Homo sapiens_hsa051690.95350509
37Cardiac muscle contraction_Homo sapiens_hsa042600.93444948
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.93172147
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93008961
40Measles_Homo sapiens_hsa051620.92305175
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89532446
42Systemic lupus erythematosus_Homo sapiens_hsa053220.88515907
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86174345
44Fatty acid elongation_Homo sapiens_hsa000620.82901335
45NF-kappa B signaling pathway_Homo sapiens_hsa040640.82501684
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82269154
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81236099
48Alzheimers disease_Homo sapiens_hsa050100.81096551
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80494546
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77575417
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.75412058
52Type I diabetes mellitus_Homo sapiens_hsa049400.73972168
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73867997
54mRNA surveillance pathway_Homo sapiens_hsa030150.72810813
55Leishmaniasis_Homo sapiens_hsa051400.72130085
56Carbon metabolism_Homo sapiens_hsa012000.71253982
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70904883
58Allograft rejection_Homo sapiens_hsa053300.70387522
59B cell receptor signaling pathway_Homo sapiens_hsa046620.69012792
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.67711636
61Acute myeloid leukemia_Homo sapiens_hsa052210.65107483
62N-Glycan biosynthesis_Homo sapiens_hsa005100.63412526
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62872601
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62172451
65HTLV-I infection_Homo sapiens_hsa051660.61465263
66Pentose phosphate pathway_Homo sapiens_hsa000300.61081791
67Legionellosis_Homo sapiens_hsa051340.59966950
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57380975
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56162809
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56110441
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55574041
72Other glycan degradation_Homo sapiens_hsa005110.55456543
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55356054
74Thyroid cancer_Homo sapiens_hsa052160.55271093
75Apoptosis_Homo sapiens_hsa042100.52463452
76Viral carcinogenesis_Homo sapiens_hsa052030.52203757
77Shigellosis_Homo sapiens_hsa051310.52038740
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51763351
79Hepatitis B_Homo sapiens_hsa051610.51735212
80Influenza A_Homo sapiens_hsa051640.50365927
81Pyruvate metabolism_Homo sapiens_hsa006200.48949797
82Asthma_Homo sapiens_hsa053100.48712847
83Viral myocarditis_Homo sapiens_hsa054160.46223602
84Arachidonic acid metabolism_Homo sapiens_hsa005900.45674195
85Fructose and mannose metabolism_Homo sapiens_hsa000510.43438870
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43202351
87Malaria_Homo sapiens_hsa051440.41326487
88Notch signaling pathway_Homo sapiens_hsa043300.41274541
89Small cell lung cancer_Homo sapiens_hsa052220.40881584
90Platelet activation_Homo sapiens_hsa046110.40058230
91Glutathione metabolism_Homo sapiens_hsa004800.39853087
92Peroxisome_Homo sapiens_hsa041460.39587315
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38913905
94Selenocompound metabolism_Homo sapiens_hsa004500.38042241
95Graft-versus-host disease_Homo sapiens_hsa053320.37841987
96Pertussis_Homo sapiens_hsa051330.36851484
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34071073
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.32550831
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31998638
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.31671965
101T cell receptor signaling pathway_Homo sapiens_hsa046600.30159754
102Osteoclast differentiation_Homo sapiens_hsa043800.29861689
103Toxoplasmosis_Homo sapiens_hsa051450.28622658
104Chronic myeloid leukemia_Homo sapiens_hsa052200.28528997
105Vitamin digestion and absorption_Homo sapiens_hsa049770.28429335
106Autoimmune thyroid disease_Homo sapiens_hsa053200.27889657
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27478478
108Galactose metabolism_Homo sapiens_hsa000520.25563057
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24979094
110Pathways in cancer_Homo sapiens_hsa052000.24518380
111Propanoate metabolism_Homo sapiens_hsa006400.24420325
112Sulfur metabolism_Homo sapiens_hsa009200.23697796
113Metabolic pathways_Homo sapiens_hsa011000.23407357
114Rheumatoid arthritis_Homo sapiens_hsa053230.23060834
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21136406
116Basal cell carcinoma_Homo sapiens_hsa052170.21005127
117Alcoholism_Homo sapiens_hsa050340.20563951
118HIF-1 signaling pathway_Homo sapiens_hsa040660.20175170
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18726968
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.18484803
121Bladder cancer_Homo sapiens_hsa052190.17686074
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14223531
123Tyrosine metabolism_Homo sapiens_hsa003500.11647043
124Phototransduction_Homo sapiens_hsa047440.10916082
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.09334490
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.05841291

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