ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytidine deamination (GO:0009972)	7.61002148
2	cytidine metabolic process (GO:0046087)	7.61002148
3	cytidine catabolic process (GO:0006216)	7.61002148
4	DNA deamination (GO:0045006)	7.45461643
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	7.32426941
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	6.64182770
7	Arp2/3 complex-mediated actin nucleation (GO:0034314)	5.03335191
8	actin nucleation (GO:0045010)	4.64544590
9	positive thymic T cell selection (GO:0045059)	4.63165612
10	positive T cell selection (GO:0043368)	4.61076615
11	ribosomal small subunit assembly (GO:0000028)	4.56369754
12	negative regulation of T cell apoptotic process (GO:0070233)	4.45094499
13	negative T cell selection (GO:0043383)	4.41286629
14	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	4.17260939
15	regulation of activation of Janus kinase activity (GO:0010533)	4.13986335
16	regulation of B cell receptor signaling pathway (GO:0050855)	4.09538663
17	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.05008696
18	sequestering of actin monomers (GO:0042989)	3.88213114
19	T cell migration (GO:0072678)	3.86538659
20	negative regulation by host of viral transcription (GO:0043922)	3.85353771
21	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.83637258
22	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.81233483
23	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.79368411
24	positive regulation of interleukin-8 secretion (GO:2000484)	3.72742130
25	cellular response to interleukin-15 (GO:0071350)	3.62687889
26	negative regulation of viral genome replication (GO:0045071)	3.61438047
27	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.55833720
28	positive regulation of calcium-mediated signaling (GO:0050850)	3.55669465
29	regulation of leukocyte mediated cytotoxicity (GO:0001910)	3.54227269
30	cytolysis (GO:0019835)	3.53497980
31	negative thymic T cell selection (GO:0045060)	3.52401335
32	regulation of natural killer cell mediated immunity (GO:0002715)	3.51120709
33	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	3.51120709
34	positive regulation of B cell differentiation (GO:0045579)	3.49210797
35	thymic T cell selection (GO:0045061)	3.47485937
36	pyrimidine nucleoside catabolic process (GO:0046135)	3.46917676
37	positive regulation of defense response to virus by host (GO:0002230)	3.42682654
38	positive regulation of cell killing (GO:0031343)	3.41412313
39	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.41158634
40	regulation of regulatory T cell differentiation (GO:0045589)	3.37881391
41	regulation of T cell receptor signaling pathway (GO:0050856)	3.37363378
42	T cell receptor signaling pathway (GO:0050852)	3.35322631
43	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.35003477
44	ATP synthesis coupled proton transport (GO:0015986)	3.35003477
45	eosinophil chemotaxis (GO:0048245)	3.32337367
46	regulation of interleukin-8 secretion (GO:2000482)	3.31021036
47	regulation of T cell mediated cytotoxicity (GO:0001914)	3.28401549
48	response to interferon-beta (GO:0035456)	3.24888950
49	positive regulation of gamma-delta T cell activation (GO:0046645)	3.24629943
50	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.21689547
51	regulation of cell killing (GO:0031341)	3.21134191
52	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.20989429
53	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	3.20928059
54	negative regulation of lymphocyte apoptotic process (GO:0070229)	3.17925053
55	regulation of T cell apoptotic process (GO:0070232)	3.17526197
56	T cell selection (GO:0045058)	3.07828236
57	protein neddylation (GO:0045116)	3.06182324
58	positive regulation of tolerance induction (GO:0002645)	3.03700279
59	mast cell activation (GO:0045576)	3.03386320
60	eosinophil migration (GO:0072677)	3.02781427
61	iron-sulfur cluster assembly (GO:0016226)	3.01445955
62	metallo-sulfur cluster assembly (GO:0031163)	3.01445955
63	respiratory electron transport chain (GO:0022904)	3.00584446
64	T cell costimulation (GO:0031295)	2.99090570
65	electron transport chain (GO:0022900)	2.98717708
66	regulation of B cell differentiation (GO:0045577)	2.98584690
67	response to pheromone (GO:0019236)	2.98036047
68	regulation of T cell tolerance induction (GO:0002664)	2.96517858
69	lymphocyte costimulation (GO:0031294)	2.95836476
70	positive regulation of T cell apoptotic process (GO:0070234)	2.93565115
71	regulation of chronic inflammatory response (GO:0002676)	2.92150482
72	positive regulation of monocyte chemotaxis (GO:0090026)	2.92141361
73	regulation of alpha-beta T cell proliferation (GO:0046640)	2.90424426
74	platelet dense granule organization (GO:0060155)	2.89256276
75	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.88489249
76	antigen receptor-mediated signaling pathway (GO:0050851)	2.87159533
77	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.85149351
78	macrophage chemotaxis (GO:0048246)	2.82072169
79	response to interleukin-15 (GO:0070672)	2.77553043
80	regulation of gamma-delta T cell differentiation (GO:0045586)	2.73164345
81	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.73141063
82	mast cell degranulation (GO:0043303)	2.71268631
83	mast cell activation involved in immune response (GO:0002279)	2.71268631
84	positive regulation of interleukin-4 production (GO:0032753)	2.69954304
85	regulation of T cell chemotaxis (GO:0010819)	2.68497106
86	positive regulation of T cell chemotaxis (GO:0010820)	2.68497106
87	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.68252626
88	negative regulation of stress fiber assembly (GO:0051497)	2.67839687
89	DNA demethylation (GO:0080111)	2.67200689
90	negative regulation of mast cell activation (GO:0033004)	2.66053395
91	negative regulation of oxidoreductase activity (GO:0051354)	2.65685549
92	viral transcription (GO:0019083)	2.64991606
93	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.64913990
94	regulation of cellular amino acid metabolic process (GO:0006521)	2.63371332
95	regulation of viral genome replication (GO:0045069)	2.62315852
96	maturation of SSU-rRNA (GO:0030490)	2.61535942
97	regulation of calcium-mediated signaling (GO:0050848)	2.61467739
98	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.57949962
99	DNA dealkylation (GO:0035510)	2.57047370
100	purine deoxyribonucleotide catabolic process (GO:0009155)	2.56637873

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.62870485
2	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.84003658
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.70882538
4	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.70643873
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.15045069
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.02407403
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.83011959
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.80006340
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.57723444
10	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.56064786
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.54202753
12	VDR_22108803_ChIP-Seq_LS180_Human	2.50573141
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.44280939
14	MYB_26560356_Chip-Seq_TH2_Human	2.30211216
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.27815579
16	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.24948644
17	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.21309686
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.03243519
19	RUNX_20019798_ChIP-Seq_JUKART_Human	1.99710506
20	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.98966619
21	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.95711252
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.93295192
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.92764384
24	ZNF274_21170338_ChIP-Seq_K562_Hela	1.92132774
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.91633200
26	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.81184728
27	GATA3_27048872_Chip-Seq_THYMUS_Human	1.77774075
28	GATA3_26560356_Chip-Seq_TH2_Human	1.75780861
29	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.66210290
30	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.61232239
31	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.61193971
32	IGF1R_20145208_ChIP-Seq_DFB_Human	1.58082873
33	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.55074350
34	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.53825731
35	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.53756168
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.53457463
37	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.48037087
38	NANOG_20526341_ChIP-Seq_ESCs_Human	1.46176460
39	AR_20517297_ChIP-Seq_VCAP_Human	1.45812209
40	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.42544052
41	FOXP3_21729870_ChIP-Seq_TREG_Human	1.42121205
42	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.39408388
43	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.37253134
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.36516330
45	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.36112594
46	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.33497602
47	TAF2_19829295_ChIP-Seq_ESCs_Human	1.33407772
48	MYB_26560356_Chip-Seq_TH1_Human	1.33148396
49	BCL6_27268052_Chip-Seq_Bcells_Human	1.32199152
50	UTX_26944678_Chip-Seq_JUKART_Human	1.31732158
51	HTT_18923047_ChIP-ChIP_STHdh_Human	1.31439365
52	MYC_18940864_ChIP-ChIP_HL60_Human	1.28613543
53	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.27458069
54	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.27085573
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24451859
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24451859
57	NCOR_22424771_ChIP-Seq_293T_Human	1.20359639
58	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.19200737
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16993892
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.16191114
61	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.13301392
62	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.12480590
63	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.11632320
64	ERG_20517297_ChIP-Seq_VCAP_Human	1.11005791
65	MYC_19829295_ChIP-Seq_ESCs_Human	1.08587533
66	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.07692510
67	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.06386896
68	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.06205268
69	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05905639
70	MAF_26560356_Chip-Seq_TH2_Human	1.05663134
71	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.05319451
72	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.04577949
73	CTCF_20526341_ChIP-Seq_ESCs_Human	1.04422544
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03845360
75	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.03587735
76	ERA_21632823_ChIP-Seq_H3396_Human	1.02531576
77	P300_27268052_Chip-Seq_Bcells_Human	1.02508961
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01543082
79	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01543082
80	ER_23166858_ChIP-Seq_MCF-7_Human	1.00665685
81	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99629845
82	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.99094408
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98681134
84	ELK1_19687146_ChIP-ChIP_HELA_Human	0.97986820
85	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.97454129
86	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96758750
87	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95370623
88	CIITA_25753668_ChIP-Seq_RAJI_Human	0.93540605
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93203118
90	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.92742207
91	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.92628801
92	P53_21459846_ChIP-Seq_SAOS-2_Human	0.92582970
93	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.92420264
94	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.91656745
95	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.91353996
96	OCT4_20526341_ChIP-Seq_ESCs_Human	0.90968331
97	CBP_20019798_ChIP-Seq_JUKART_Human	0.90599840
98	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.90599840
99	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	0.90421773
100	E2F1_20622854_ChIP-Seq_HELA_Human	0.90210603

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	5.79018635
2	MP0009785_altered_susceptibility_to	3.28531781
3	MP0001835_abnormal_antigen_presentation	3.15982268
4	MP0003763_abnormal_thymus_physiology	2.81862662
5	MP0005000_abnormal_immune_tolerance	2.45350691
6	MP0001800_abnormal_humoral_immune	2.36490397
7	MP0009333_abnormal_splenocyte_physiolog	2.23141587
8	MP0009379_abnormal_foot_pigmentation	2.20806576
9	MP0005025_abnormal_response_to	2.17689756
10	MP0002723_abnormal_immune_serum	2.15938509
11	MP0003646_muscle_fatigue	2.11163162
12	MP0002420_abnormal_adaptive_immunity	2.10387593
13	MP0002148_abnormal_hypersensitivity_rea	2.09427514
14	MP0002166_altered_tumor_susceptibility	2.05967677
15	MP0001819_abnormal_immune_cell	2.05400414
16	MP0000685_abnormal_immune_system	1.98277349
17	MP0003866_abnormal_defecation	1.94556558
18	MP0005645_abnormal_hypothalamus_physiol	1.85332214
19	MP0003878_abnormal_ear_physiology	1.82277290
20	MP0005377_hearing/vestibular/ear_phenot	1.82277290
21	MP0006072_abnormal_retinal_apoptosis	1.80792176
22	MP0001790_abnormal_immune_system	1.80381885
23	MP0005387_immune_system_phenotype	1.80381885
24	MP0002452_abnormal_antigen_presenting	1.78726179
25	MP0002006_tumorigenesis	1.65882478
26	MP0008872_abnormal_physiological_respon	1.62489198
27	MP0002102_abnormal_ear_morphology	1.61724421
28	MP0000716_abnormal_immune_system	1.60869566
29	MP0006082_CNS_inflammation	1.60745722
30	MP0002163_abnormal_gland_morphology	1.59849113
31	MP0002876_abnormal_thyroid_physiology	1.58721273
32	MP0005646_abnormal_pituitary_gland	1.56258880
33	MP0000372_irregular_coat_pigmentation	1.55344936
34	MP0001919_abnormal_reproductive_system	1.54400453
35	MP0010155_abnormal_intestine_physiology	1.50907960
36	MP0002398_abnormal_bone_marrow	1.50568611
37	MP0001905_abnormal_dopamine_level	1.49669932
38	MP0005551_abnormal_eye_electrophysiolog	1.47202871
39	MP0001873_stomach_inflammation	1.47162793
40	MP0005075_abnormal_melanosome_morpholog	1.46812752
41	MP0003011_delayed_dark_adaptation	1.46239125
42	MP0002138_abnormal_hepatobiliary_system	1.44163319
43	MP0004147_increased_porphyrin_level	1.41637842
44	MP0008875_abnormal_xenobiotic_pharmacok	1.40386149
45	MP0002837_dystrophic_cardiac_calcinosis	1.39764250
46	MP0003724_increased_susceptibility_to	1.39101504
47	MP0001968_abnormal_touch/_nociception	1.36677250
48	MP0003436_decreased_susceptibility_to	1.35018355
49	MP0006292_abnormal_olfactory_placode	1.35014326
50	MP0001845_abnormal_inflammatory_respons	1.34733580
51	MP0005389_reproductive_system_phenotype	1.34020028
52	MP0002405_respiratory_system_inflammati	1.31494310
53	MP0002933_joint_inflammation	1.31413609
54	MP0004145_abnormal_muscle_electrophysio	1.27457102
55	MP0000689_abnormal_spleen_morphology	1.26924343
56	MP0000703_abnormal_thymus_morphology	1.26729781
57	MP0002419_abnormal_innate_immunity	1.26544463
58	MP0002736_abnormal_nociception_after	1.25251735
59	MP0002722_abnormal_immune_system	1.23116815
60	MP0002277_abnormal_respiratory_mucosa	1.20495079
61	MP0002429_abnormal_blood_cell	1.17325986
62	MP0001986_abnormal_taste_sensitivity	1.13634927
63	MP0002095_abnormal_skin_pigmentation	1.09155748
64	MP0009764_decreased_sensitivity_to	1.08501828
65	MP0005253_abnormal_eye_physiology	1.08317730
66	MP0003195_calcinosis	1.07087698
67	MP0005084_abnormal_gallbladder_morpholo	1.05614180
68	MP0008469_abnormal_protein_level	1.03239345
69	MP0005464_abnormal_platelet_physiology	1.02462866
70	MP0005379_endocrine/exocrine_gland_phen	1.01412951
71	MP0003786_premature_aging	0.99518097
72	MP0003880_abnormal_central_pattern	0.99417557
73	MP0003045_fibrosis	0.97607587
74	MP0005410_abnormal_fertilization	0.94399114
75	MP0002638_abnormal_pupillary_reflex	0.92889424
76	MP0001765_abnormal_ion_homeostasis	0.92174314
77	MP0001485_abnormal_pinna_reflex	0.91760007
78	MP0004885_abnormal_endolymph	0.91656035
79	MP0002693_abnormal_pancreas_physiology	0.90304513
80	MP0003448_altered_tumor_morphology	0.88258665
81	MP0001542_abnormal_bone_strength	0.86456511
82	MP0008877_abnormal_DNA_methylation	0.86020381
83	MP0006276_abnormal_autonomic_nervous	0.84731305
84	MP0002653_abnormal_ependyma_morphology	0.84071192
85	MP0003787_abnormal_imprinting	0.83691457
86	MP0002160_abnormal_reproductive_system	0.83327797
87	MP0003252_abnormal_bile_duct	0.82184930
88	MP0001501_abnormal_sleep_pattern	0.79860209
89	MP0009745_abnormal_behavioral_response	0.79695507
90	MP0005636_abnormal_mineral_homeostasis	0.78179288
91	MP0001764_abnormal_homeostasis	0.77884492
92	MP0002733_abnormal_thermal_nociception	0.76594531
93	MP0009763_increased_sensitivity_to	0.74015739
94	MP0001533_abnormal_skeleton_physiology	0.73368715
95	MP0008995_early_reproductive_senescence	0.73252332
96	MP0004947_skin_inflammation	0.72121786
97	MP0004742_abnormal_vestibular_system	0.69656536
98	MP0001970_abnormal_pain_threshold	0.68985529
99	MP0002272_abnormal_nervous_system	0.68814124
100	MP0004142_abnormal_muscle_tone	0.68671883

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	4.78395676
2	T lymphocytopenia (HP:0005403)	4.74772910
3	Aplastic anemia (HP:0001915)	4.73044441
4	Abnormality of T cell number (HP:0011839)	4.65923158
5	Elevated erythrocyte sedimentation rate (HP:0003565)	4.56432587
6	Severe combined immunodeficiency (HP:0004430)	4.44328769
7	Hypoproteinemia (HP:0003075)	4.25883120
8	Congenital stationary night blindness (HP:0007642)	3.69102178
9	Thyroiditis (HP:0100646)	3.60127813
10	Abnormality of B cell number (HP:0010975)	3.58684024
11	Mitochondrial inheritance (HP:0001427)	3.58238962
12	Combined immunodeficiency (HP:0005387)	3.43155522
13	Autoimmune hemolytic anemia (HP:0001890)	3.43132465
14	Increased IgM level (HP:0003496)	3.41950012
15	Abnormality of T cells (HP:0002843)	3.41803917
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.34409333
17	Acute necrotizing encephalopathy (HP:0006965)	3.29981891
18	Increased intramyocellular lipid droplets (HP:0012240)	3.23811903
19	Abnormal mitochondria in muscle tissue (HP:0008316)	3.17206983
20	Abnormality of eosinophils (HP:0001879)	3.09145506
21	Hepatocellular necrosis (HP:0001404)	3.08519214
22	B lymphocytopenia (HP:0010976)	3.06181320
23	3-Methylglutaconic aciduria (HP:0003535)	3.02227052
24	Abnormality of the prostate (HP:0008775)	3.00305436
25	Increased CSF lactate (HP:0002490)	2.96125828
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.93995643
27	Increased hepatocellular lipid droplets (HP:0006565)	2.84375925
28	Pancreatic cysts (HP:0001737)	2.77756787
29	Abolished electroretinogram (ERG) (HP:0000550)	2.73107784
30	Progressive macrocephaly (HP:0004481)	2.72546874
31	Attenuation of retinal blood vessels (HP:0007843)	2.69204245
32	Hepatic necrosis (HP:0002605)	2.68976210
33	Increased muscle lipid content (HP:0009058)	2.66169651
34	Encephalitis (HP:0002383)	2.58569494
35	Eosinophilia (HP:0001880)	2.57454922
36	Acute encephalopathy (HP:0006846)	2.55508377
37	Stomatitis (HP:0010280)	2.54411418
38	Lipid accumulation in hepatocytes (HP:0006561)	2.51367434
39	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.49438027
40	True hermaphroditism (HP:0010459)	2.48758798
41	Renal Fanconi syndrome (HP:0001994)	2.47821871
42	Pancreatic fibrosis (HP:0100732)	2.45487512
43	Panhypogammaglobulinemia (HP:0003139)	2.43879831
44	Decreased central vision (HP:0007663)	2.37414346
45	Pancytopenia (HP:0001876)	2.36206125
46	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.35333465
47	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.35333465
48	Molar tooth sign on MRI (HP:0002419)	2.34701849
49	Abnormality of midbrain morphology (HP:0002418)	2.34701849
50	Chronic diarrhea (HP:0002028)	2.32967040
51	Leukocytosis (HP:0001974)	2.31581244
52	Autoimmune thrombocytopenia (HP:0001973)	2.28755796
53	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.27147798
54	Hypoplasia of the thymus (HP:0000778)	2.25714945
55	Cerebral edema (HP:0002181)	2.24098957
56	Optic disc pallor (HP:0000543)	2.20808568
57	Agammaglobulinemia (HP:0004432)	2.15442293
58	Recurrent bronchitis (HP:0002837)	2.15043396
59	Myositis (HP:0100614)	2.11751724
60	Hypoalbuminemia (HP:0003073)	2.10618587
61	Abnormal albumin level (HP:0012116)	2.10618587
62	IgM deficiency (HP:0002850)	2.10418131
63	Exertional dyspnea (HP:0002875)	2.08316507
64	Meningitis (HP:0001287)	2.08083891
65	Abnormality of T cell physiology (HP:0011840)	2.03261276
66	Type 2 muscle fiber atrophy (HP:0003554)	2.02905079
67	Methylmalonic acidemia (HP:0002912)	2.01705625
68	Increased serum lactate (HP:0002151)	2.01328903
69	Lymphopenia (HP:0001888)	2.00315993
70	Absent thumb (HP:0009777)	1.99821937
71	Prostate neoplasm (HP:0100787)	1.99798941
72	Lactic acidosis (HP:0003128)	1.96652767
73	Abnormality of the renal cortex (HP:0011035)	1.96184098
74	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.95028173
75	Constricted visual fields (HP:0001133)	1.94428838
76	Renal cortical cysts (HP:0000803)	1.94137797
77	Abnormality of cells of the lymphoid lineage (HP:0012140)	1.93512043
78	Chronic obstructive pulmonary disease (HP:0006510)	1.92518451
79	Obstructive lung disease (HP:0006536)	1.92518451
80	Pustule (HP:0200039)	1.92179110
81	Granulocytopenia (HP:0001913)	1.91495210
82	Cerebral palsy (HP:0100021)	1.90319260
83	Hypergammaglobulinemia (HP:0010702)	1.89818360
84	Methylmalonic aciduria (HP:0012120)	1.87757987
85	Recurrent cutaneous fungal infections (HP:0011370)	1.85466477
86	Chronic mucocutaneous candidiasis (HP:0002728)	1.85466477
87	Ketosis (HP:0001946)	1.84814476
88	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.84390179
89	Abnormality of cells of the erythroid lineage (HP:0012130)	1.82346806
90	Medial flaring of the eyebrow (HP:0010747)	1.80987807
91	Abnormality of DNA repair (HP:0003254)	1.80288617
92	Pulmonary infiltrates (HP:0002113)	1.79704416
93	Keratoconus (HP:0000563)	1.78141205
94	Increased corneal curvature (HP:0100692)	1.78141205
95	Nephronophthisis (HP:0000090)	1.77720785
96	Severe visual impairment (HP:0001141)	1.77664088
97	Vasculitis (HP:0002633)	1.76737563
98	Lymphoma (HP:0002665)	1.76223514
99	Lethargy (HP:0001254)	1.75845447
100	Abnormal number of erythroid precursors (HP:0012131)	1.75764269

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	5.23913308
2	TESK2	5.09046563
3	KDR	4.96765154
4	TAOK3	3.19722719
5	BCKDK	3.16848313
6	MAP4K2	2.46184028
7	MAP4K1	2.44929978
8	ZAK	2.31827765
9	ITK	2.31725111
10	ADRBK2	2.14069238
11	TLK1	2.05232238
12	VRK2	2.04127458
13	GRK1	1.94312089
14	LIMK1	1.90193331
15	STK16	1.85070948
16	GRK6	1.79279717
17	MUSK	1.75754600
18	TESK1	1.60226402
19	SYK	1.51873553
20	TEC	1.49624562
21	SCYL2	1.48054902
22	NUAK1	1.46079652
23	MAP3K12	1.42865066
24	FES	1.40783970
25	FRK	1.39705009
26	CDK19	1.36830509
27	PASK	1.27801561
28	PINK1	1.25210062
29	BTK	1.24767801
30	ZAP70	1.23560598
31	VRK1	1.21212422
32	PRKCQ	1.20896104
33	LCK	1.16071236
34	MAPKAPK3	1.13158308
35	MAP3K11	1.12436023
36	IKBKE	1.12012860
37	TNK2	1.10762949
38	IKBKB	1.01976203
39	WNK4	0.99675235
40	GRK7	0.97331443
41	CSK	0.96277262
42	TBK1	0.94538672
43	KIT	0.93074182
44	DAPK1	0.92055503
45	CAMKK2	0.89532660
46	LYN	0.89359271
47	MST4	0.87357060
48	TIE1	0.85463678
49	PIK3CA	0.81934884
50	CSF1R	0.79630173
51	BMPR1B	0.76099155
52	DAPK2	0.75381702
53	CAMKK1	0.75003503
54	MYLK	0.73097295
55	INSRR	0.72380254
56	PIM1	0.68131588
57	PIM2	0.66416466
58	RPS6KA5	0.64664812
59	PIK3CG	0.64101569
60	MAP2K7	0.63778493
61	JAK3	0.61718531
62	ADRBK1	0.55230362
63	GRK5	0.55222861
64	WNK3	0.53632788
65	OBSCN	0.51607595
66	IGF1R	0.50290627
67	BMPR2	0.48993988
68	MAPKAPK5	0.47732837
69	RIPK4	0.46892699
70	DAPK3	0.45817861
71	MAP2K6	0.45354069
72	FYN	0.44038558
73	PRKCA	0.39921228
74	ROCK1	0.39727172
75	MAPK13	0.39689062
76	EIF2AK3	0.38966202
77	RPS6KA4	0.38695342
78	AURKA	0.38664151
79	CDK8	0.37729862
80	DYRK2	0.37661853
81	PRKACA	0.35744336
82	ERBB3	0.35109355
83	NME1	0.34681654
84	HCK	0.34528620
85	OXSR1	0.34213767
86	CSNK1G3	0.33859309
87	INSR	0.33323971
88	PRKCH	0.29722959
89	ABL1	0.26013734
90	MATK	0.25980198
91	PRKCD	0.25738895
92	BUB1	0.24470795
93	MAP2K2	0.23667806
94	TRPM7	0.23583318
95	CAMK1	0.22612220
96	CAMK2A	0.21896523
97	CSNK2A1	0.20760039
98	FLT3	0.20625326
99	PHKG1	0.17927222
100	PHKG2	0.17927222

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	5.23317530
2	Proteasome_Homo sapiens_hsa03050	3.52133988
3	Graft-versus-host disease_Homo sapiens_hsa05332	3.27351185
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.23881199
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.02574520
6	Allograft rejection_Homo sapiens_hsa05330	2.93674748
7	Ribosome_Homo sapiens_hsa03010	2.91281784
8	Antigen processing and presentation_Homo sapiens_hsa04612	2.82478167
9	Parkinsons disease_Homo sapiens_hsa05012	2.60138840
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.44665525
11	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.34655270
12	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.28058429
13	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	2.04977812
14	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.00644629
15	Phototransduction_Homo sapiens_hsa04744	1.99630828
16	Asthma_Homo sapiens_hsa05310	1.91636671
17	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.84505760
18	Alzheimers disease_Homo sapiens_hsa05010	1.75340245
19	RNA polymerase_Homo sapiens_hsa03020	1.68817762
20	Rheumatoid arthritis_Homo sapiens_hsa05323	1.67811607
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.64493489
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.59221310
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.53556545
24	Caffeine metabolism_Homo sapiens_hsa00232	1.51654611
25	Huntingtons disease_Homo sapiens_hsa05016	1.48489618
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.43730501
27	Protein export_Homo sapiens_hsa03060	1.40603168
28	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.32214620
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.29366045
30	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.21003073
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.18872522
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.16310233
33	Viral myocarditis_Homo sapiens_hsa05416	1.11534382
34	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.06734397
35	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.02824321
36	Peroxisome_Homo sapiens_hsa04146	0.95457751
37	Measles_Homo sapiens_hsa05162	0.93426110
38	Homologous recombination_Homo sapiens_hsa03440	0.92411037
39	Olfactory transduction_Homo sapiens_hsa04740	0.91835879
40	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.88894171
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.83782318
42	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.82728830
43	RNA degradation_Homo sapiens_hsa03018	0.81964685
44	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.79222171
45	Malaria_Homo sapiens_hsa05144	0.78557092
46	Pyrimidine metabolism_Homo sapiens_hsa00240	0.77478735
47	Retinol metabolism_Homo sapiens_hsa00830	0.77117036
48	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.76236837
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73487111
50	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.71486447
51	Fanconi anemia pathway_Homo sapiens_hsa03460	0.70978868
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.70435045
53	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.68749787
54	Shigellosis_Homo sapiens_hsa05131	0.68496080
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68206057
56	Salmonella infection_Homo sapiens_hsa05132	0.65803613
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.64063277
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62810796
59	Butanoate metabolism_Homo sapiens_hsa00650	0.61537052
60	Purine metabolism_Homo sapiens_hsa00230	0.60186413
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.59995989
62	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.59561421
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.57927731
64	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.55403341
65	Propanoate metabolism_Homo sapiens_hsa00640	0.53060243
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.52152386
67	One carbon pool by folate_Homo sapiens_hsa00670	0.50648606
68	Herpes simplex infection_Homo sapiens_hsa05168	0.47030656
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44943809
70	Regulation of autophagy_Homo sapiens_hsa04140	0.44283237
71	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.41265055
72	Taste transduction_Homo sapiens_hsa04742	0.40567017
73	Nicotine addiction_Homo sapiens_hsa05033	0.40227668
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.39529695
75	Leishmaniasis_Homo sapiens_hsa05140	0.39500687
76	Salivary secretion_Homo sapiens_hsa04970	0.37267374
77	Metabolic pathways_Homo sapiens_hsa01100	0.37160573
78	Morphine addiction_Homo sapiens_hsa05032	0.36597810
79	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36427632
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.35875388
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34340196
82	Nucleotide excision repair_Homo sapiens_hsa03420	0.33611348
83	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.31856870
84	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.29960690
85	ABC transporters_Homo sapiens_hsa02010	0.28833418
86	Basal transcription factors_Homo sapiens_hsa03022	0.28816076
87	Sulfur relay system_Homo sapiens_hsa04122	0.28150383
88	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.23955932
89	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.22732193
90	Selenocompound metabolism_Homo sapiens_hsa00450	0.22358819
91	Chemokine signaling pathway_Homo sapiens_hsa04062	0.22278107
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.22023529
93	African trypanosomiasis_Homo sapiens_hsa05143	0.21952140
94	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.21033889
95	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.20616363
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.20295047
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.18074065
98	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.18060016
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.17984366
100	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.17895985

RPL18AP15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »