RPL18AP16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.98154854
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.67618902
3cytidine deamination (GO:0009972)6.39418578
4cytidine metabolic process (GO:0046087)6.39418578
5cytidine catabolic process (GO:0006216)6.39418578
6ribosomal small subunit assembly (GO:0000028)6.01502057
7pyrimidine ribonucleoside catabolic process (GO:0046133)5.68372357
8viral transcription (GO:0019083)4.63435912
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.63098489
10ATP synthesis coupled proton transport (GO:0015986)4.63098489
11translational termination (GO:0006415)4.45102983
12maturation of SSU-rRNA (GO:0030490)4.28432138
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.27183869
14translational elongation (GO:0006414)4.11608295
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.10391855
16protein neddylation (GO:0045116)4.05277560
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.99377624
18water-soluble vitamin biosynthetic process (GO:0042364)3.98120028
19protein targeting to ER (GO:0045047)3.91854455
20cotranslational protein targeting to membrane (GO:0006613)3.91587758
21protein localization to endoplasmic reticulum (GO:0070972)3.71962102
22respiratory electron transport chain (GO:0022904)3.71682945
23establishment of protein localization to endoplasmic reticulum (GO:0072599)3.70790567
24electron transport chain (GO:0022900)3.69414055
25behavioral response to nicotine (GO:0035095)3.64417210
26protein complex biogenesis (GO:0070271)3.58663358
27positive thymic T cell selection (GO:0045059)3.53777557
28Arp2/3 complex-mediated actin nucleation (GO:0034314)3.45467054
29positive T cell selection (GO:0043368)3.42503891
30negative regulation by host of viral transcription (GO:0043922)3.40697869
31ribosomal small subunit biogenesis (GO:0042274)3.35145628
32viral life cycle (GO:0019058)3.32877125
33negative T cell selection (GO:0043383)3.31466164
34actin nucleation (GO:0045010)3.30276489
35mitochondrial respiratory chain complex assembly (GO:0033108)3.28941897
36cellular protein complex disassembly (GO:0043624)3.28714577
37response to interferon-beta (GO:0035456)3.17572533
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16377822
39response to pheromone (GO:0019236)3.15811735
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14880485
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.10295587
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.10295587
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.08397282
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.08397282
45NADH dehydrogenase complex assembly (GO:0010257)3.08397282
46translational initiation (GO:0006413)3.05452617
47pyrimidine nucleoside catabolic process (GO:0046135)3.05344582
48pseudouridine synthesis (GO:0001522)3.03572592
49translation (GO:0006412)3.03257882
50pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.02959704
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.95365746
52purine deoxyribonucleotide catabolic process (GO:0009155)2.93222256
53negative regulation of viral genome replication (GO:0045071)2.93181928
54sequestering of actin monomers (GO:0042989)2.92761091
55positive regulation of calcium-mediated signaling (GO:0050850)2.92570936
56negative regulation of T cell apoptotic process (GO:0070233)2.90423030
57negative regulation of telomere maintenance (GO:0032205)2.87178965
58establishment of protein localization to mitochondrial membrane (GO:0090151)2.87149165
59mannosylation (GO:0097502)2.86943334
60regulation of cellular amino acid metabolic process (GO:0006521)2.85656420
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84870512
62rRNA modification (GO:0000154)2.83695947
63DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80286540
64positive regulation of defense response to virus by host (GO:0002230)2.79911279
65deoxyribonucleotide catabolic process (GO:0009264)2.77302371
66deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.76626967
67cytochrome complex assembly (GO:0017004)2.74175716
68transcription elongation from RNA polymerase III promoter (GO:0006385)2.73412565
69termination of RNA polymerase III transcription (GO:0006386)2.73412565
70deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.70647023
71negative thymic T cell selection (GO:0045060)2.69165204
72intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68067859
73signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68067859
74signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.67801652
75signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.67801652
76signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.67801652
77positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.67776731
78positive regulation of T cell apoptotic process (GO:0070234)2.66345024
79ATP biosynthetic process (GO:0006754)2.66028596
80epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.65605578
81ubiquinone biosynthetic process (GO:0006744)2.63819356
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.62720278
83hydrogen ion transmembrane transport (GO:1902600)2.62524671
84negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.61887760
85base-excision repair, AP site formation (GO:0006285)2.61696863
86L-fucose catabolic process (GO:0042355)2.61629420
87fucose catabolic process (GO:0019317)2.61629420
88L-fucose metabolic process (GO:0042354)2.61629420
89pyrimidine nucleotide catabolic process (GO:0006244)2.61403777
90protein complex disassembly (GO:0043241)2.59787228
91respiratory chain complex IV assembly (GO:0008535)2.59652040
92chaperone-mediated protein transport (GO:0072321)2.59573694
93purine nucleotide salvage (GO:0032261)2.58274364
94positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.58012591
95cellular response to interferon-beta (GO:0035458)2.56459416
96proton transport (GO:0015992)2.54883444
97positive regulation of T cell mediated cytotoxicity (GO:0001916)2.54505423
98positive regulation of natural killer cell mediated immunity (GO:0002717)2.53954826
99thymic T cell selection (GO:0045061)2.53561799
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.51989654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.38986484
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.17325085
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.66976733
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.51827570
5EZH2_22144423_ChIP-Seq_EOC_Human3.09017076
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.00334578
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99697563
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.80849753
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.80545162
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.65420192
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59070629
12VDR_22108803_ChIP-Seq_LS180_Human2.58676694
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55564441
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.38888485
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38021330
16VDR_23849224_ChIP-Seq_CD4+_Human2.31857975
17ZNF274_21170338_ChIP-Seq_K562_Hela2.27675876
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.24185211
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96646411
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.92050354
21FOXP3_21729870_ChIP-Seq_TREG_Human1.89318220
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.81485349
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79169204
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.75339276
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73434410
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71148818
27IGF1R_20145208_ChIP-Seq_DFB_Human1.69117053
28MYC_18940864_ChIP-ChIP_HL60_Human1.61505294
29TP53_22573176_ChIP-Seq_HFKS_Human1.55740504
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.50492545
31EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.48998181
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46999891
33ELK1_19687146_ChIP-ChIP_HELA_Human1.46780522
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46354456
35AR_20517297_ChIP-Seq_VCAP_Human1.44936765
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41863923
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40654384
38RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.39194951
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36938233
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.36874598
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32493165
42NANOG_20526341_ChIP-Seq_ESCs_Human1.29883526
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29836739
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.29836739
45TAF2_19829295_ChIP-Seq_ESCs_Human1.29404718
46EWS_26573619_Chip-Seq_HEK293_Human1.28111581
47GATA3_26560356_Chip-Seq_TH2_Human1.27494136
48GATA3_21878914_ChIP-Seq_MCF-7_Human1.27180829
49MYB_26560356_Chip-Seq_TH2_Human1.26468997
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26155640
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25679553
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.23031520
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22745467
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.22390685
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21848338
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20932170
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20565544
58BCL6_27268052_Chip-Seq_Bcells_Human1.18624092
59AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13927563
60TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13563041
61NCOR_22424771_ChIP-Seq_293T_Human1.11810829
62ERG_20517297_ChIP-Seq_VCAP_Human1.11250593
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10191736
64MYC_19829295_ChIP-Seq_ESCs_Human1.08957439
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08027093
66IRF1_19129219_ChIP-ChIP_H3396_Human1.07752465
67PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07450847
68ERA_21632823_ChIP-Seq_H3396_Human1.05946550
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05885857
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05794861
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04223774
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03420059
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03285389
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02171315
75NANOG_19829295_ChIP-Seq_ESCs_Human1.01612205
76SOX2_19829295_ChIP-Seq_ESCs_Human1.01612205
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00564423
78TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00558096
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99551724
80ER_23166858_ChIP-Seq_MCF-7_Human0.99421916
81HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98118898
82YY1_22570637_ChIP-Seq_MALME-3M_Human0.97924358
83EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97597898
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96882787
85P53_21459846_ChIP-Seq_SAOS-2_Human0.95817859
86CTCF_20526341_ChIP-Seq_ESCs_Human0.95203542
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95162983
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95022729
89FUS_26573619_Chip-Seq_HEK293_Human0.94774288
90P300_27268052_Chip-Seq_Bcells_Human0.93743940
91CIITA_25753668_ChIP-Seq_RAJI_Human0.93527722
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93467906
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92715595
94GABP_19822575_ChIP-Seq_HepG2_Human0.91303774
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.91159180
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90980511
97HOXB7_26014856_ChIP-Seq_BT474_Human0.90978987
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90924030
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.89684442
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89459048

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.89995606
2MP0009379_abnormal_foot_pigmentation3.32089644
3MP0006292_abnormal_olfactory_placode2.81244360
4MP0001835_abnormal_antigen_presentation2.63050949
5MP0000372_irregular_coat_pigmentation2.39955529
6MP0003646_muscle_fatigue2.31385547
7MP0002102_abnormal_ear_morphology2.25083748
8MP0009785_altered_susceptibility_to2.24102147
9MP0002163_abnormal_gland_morphology2.20717117
10MP0002837_dystrophic_cardiac_calcinosis2.06636482
11MP0002876_abnormal_thyroid_physiology2.03861149
12MP0002138_abnormal_hepatobiliary_system2.00634193
13MP0006072_abnormal_retinal_apoptosis1.99736335
14MP0009333_abnormal_splenocyte_physiolog1.98145909
15MP0003011_delayed_dark_adaptation1.96237238
16MP0001800_abnormal_humoral_immune1.94675420
17MP0008875_abnormal_xenobiotic_pharmacok1.93643886
18MP0008872_abnormal_physiological_respon1.93213446
19MP0001968_abnormal_touch/_nociception1.92379007
20MP0002148_abnormal_hypersensitivity_rea1.88684123
21MP0005646_abnormal_pituitary_gland1.86906740
22MP0008877_abnormal_DNA_methylation1.82532413
23MP0002166_altered_tumor_susceptibility1.79739058
24MP0005000_abnormal_immune_tolerance1.78819464
25MP0005551_abnormal_eye_electrophysiolog1.68860943
26MP0002277_abnormal_respiratory_mucosa1.67632266
27MP0002723_abnormal_immune_serum1.67172068
28MP0001790_abnormal_immune_system1.65393954
29MP0005387_immune_system_phenotype1.65393954
30MP0000685_abnormal_immune_system1.60852537
31MP0002736_abnormal_nociception_after1.59413274
32MP0002420_abnormal_adaptive_immunity1.59236300
33MP0005645_abnormal_hypothalamus_physiol1.57483121
34MP0002006_tumorigenesis1.56199390
35MP0001819_abnormal_immune_cell1.55144155
36MP0003878_abnormal_ear_physiology1.54484420
37MP0005377_hearing/vestibular/ear_phenot1.54484420
38MP0003763_abnormal_thymus_physiology1.50624356
39MP0004885_abnormal_endolymph1.50231362
40MP0001919_abnormal_reproductive_system1.48004848
41MP0005253_abnormal_eye_physiology1.45997311
42MP0004147_increased_porphyrin_level1.44329304
43MP0003866_abnormal_defecation1.44163860
44MP0005389_reproductive_system_phenotype1.42946144
45MP0002452_abnormal_antigen_presenting1.38684474
46MP0004145_abnormal_muscle_electrophysio1.35020480
47MP0001986_abnormal_taste_sensitivity1.33930319
48MP0005025_abnormal_response_to1.31349590
49MP0001485_abnormal_pinna_reflex1.28864862
50MP0005379_endocrine/exocrine_gland_phen1.28659661
51MP0008058_abnormal_DNA_repair1.27204338
52MP0005084_abnormal_gallbladder_morpholo1.26393161
53MP0000716_abnormal_immune_system1.20524793
54MP0005075_abnormal_melanosome_morpholog1.19722167
55MP0006276_abnormal_autonomic_nervous1.15899221
56MP0002398_abnormal_bone_marrow1.13674303
57MP0001905_abnormal_dopamine_level1.13641330
58MP0002160_abnormal_reproductive_system1.12587265
59MP0004142_abnormal_muscle_tone1.11486827
60MP0001873_stomach_inflammation1.10992728
61MP0002733_abnormal_thermal_nociception1.08348863
62MP0003786_premature_aging1.07625794
63MP0003806_abnormal_nucleotide_metabolis1.06178809
64MP0002638_abnormal_pupillary_reflex1.05727490
65MP0001348_abnormal_lacrimal_gland1.05311167
66MP0001293_anophthalmia1.04580590
67MP0003787_abnormal_imprinting1.03193086
68MP0002095_abnormal_skin_pigmentation1.01864200
69MP0003195_calcinosis1.01757965
70MP0005410_abnormal_fertilization1.00773806
71MP0010155_abnormal_intestine_physiology0.98022104
72MP0009764_decreased_sensitivity_to0.97970919
73MP0000631_abnormal_neuroendocrine_gland0.96060475
74MP0001845_abnormal_inflammatory_respons0.94902379
75MP0002429_abnormal_blood_cell0.91735458
76MP0008789_abnormal_olfactory_epithelium0.91575312
77MP0001970_abnormal_pain_threshold0.91150965
78MP0000689_abnormal_spleen_morphology0.90129592
79MP0000703_abnormal_thymus_morphology0.87576357
80MP0005636_abnormal_mineral_homeostasis0.87486966
81MP0003436_decreased_susceptibility_to0.87048435
82MP0006036_abnormal_mitochondrial_physio0.86728340
83MP0002234_abnormal_pharynx_morphology0.86715865
84MP0002272_abnormal_nervous_system0.86326820
85MP0009745_abnormal_behavioral_response0.85364721
86MP0002722_abnormal_immune_system0.83782820
87MP0008995_early_reproductive_senescence0.80341184
88MP0002405_respiratory_system_inflammati0.76871903
89MP0005083_abnormal_biliary_tract0.76399767
90MP0001984_abnormal_olfaction0.76221514
91MP0002693_abnormal_pancreas_physiology0.75861058
92MP0000049_abnormal_middle_ear0.74861870
93MP0002735_abnormal_chemical_nociception0.73335476
94MP0001440_abnormal_grooming_behavior0.72903679
95MP0001119_abnormal_female_reproductive0.71883563
96MP0003186_abnormal_redox_activity0.71602255
97MP0003137_abnormal_impulse_conducting0.70834224
98MP0004043_abnormal_pH_regulation0.70622384
99MP0004742_abnormal_vestibular_system0.67942157
100MP0005195_abnormal_posterior_eye0.67941470

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.15898385
2Mitochondrial inheritance (HP:0001427)3.91644178
3Acute necrotizing encephalopathy (HP:0006965)3.90430766
4IgG deficiency (HP:0004315)3.72704558
5Abnormal mitochondria in muscle tissue (HP:0008316)3.68556686
63-Methylglutaconic aciduria (HP:0003535)3.66185071
7Hepatocellular necrosis (HP:0001404)3.64861473
8Severe combined immunodeficiency (HP:0004430)3.62500406
9Elevated erythrocyte sedimentation rate (HP:0003565)3.46826896
10B lymphocytopenia (HP:0010976)3.46045871
11Hypoproteinemia (HP:0003075)3.43802972
12Increased CSF lactate (HP:0002490)3.42246111
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.36223579
14Abnormality of B cell number (HP:0010975)3.36066757
15Acute encephalopathy (HP:0006846)3.23349149
16Progressive macrocephaly (HP:0004481)3.22914955
17Hepatic necrosis (HP:0002605)3.16753803
18T lymphocytopenia (HP:0005403)3.11275159
19Pancreatic cysts (HP:0001737)3.09642664
20Aplastic anemia (HP:0001915)3.05447679
21Abnormality of T cell number (HP:0011839)3.04865091
22Decreased central vision (HP:0007663)3.04677679
23Autoimmune hemolytic anemia (HP:0001890)2.98794818
24Thyroiditis (HP:0100646)2.97872892
25Increased intramyocellular lipid droplets (HP:0012240)2.94847786
26Increased hepatocellular lipid droplets (HP:0006565)2.86601730
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.84060360
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.84060360
29Abnormal rod and cone electroretinograms (HP:0008323)2.78219800
30Abnormality of cells of the erythroid lineage (HP:0012130)2.75023645
31Pancreatic fibrosis (HP:0100732)2.72797552
32Methylmalonic acidemia (HP:0002912)2.71267537
33Cerebral edema (HP:0002181)2.68184880
34Combined immunodeficiency (HP:0005387)2.67611578
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.66749040
36Abnormal number of erythroid precursors (HP:0012131)2.63553046
37Lipid accumulation in hepatocytes (HP:0006561)2.61109697
38Abolished electroretinogram (ERG) (HP:0000550)2.60912090
39Aplasia/Hypoplasia of the spleen (HP:0010451)2.60726128
40Eosinophilia (HP:0001880)2.60294610
41Attenuation of retinal blood vessels (HP:0007843)2.55324820
42Asplenia (HP:0001746)2.55098411
43Abnormality of T cells (HP:0002843)2.49956144
44Abnormality of eosinophils (HP:0001879)2.49486568
45Reticulocytopenia (HP:0001896)2.49368241
46Panhypogammaglobulinemia (HP:0003139)2.47076348
47Increased serum lactate (HP:0002151)2.46165192
48Increased muscle lipid content (HP:0009058)2.44910568
49Methylmalonic aciduria (HP:0012120)2.44612918
50Type II lissencephaly (HP:0007260)2.40604602
51Optic disc pallor (HP:0000543)2.40407504
52True hermaphroditism (HP:0010459)2.39213061
53Increased IgM level (HP:0003496)2.36839865
54Renal Fanconi syndrome (HP:0001994)2.33676137
55Molar tooth sign on MRI (HP:0002419)2.29259409
56Abnormality of midbrain morphology (HP:0002418)2.29259409
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24420618
58Lactic acidosis (HP:0003128)2.24242617
59Type 2 muscle fiber atrophy (HP:0003554)2.23853550
60Pancytopenia (HP:0001876)2.21833020
61Colon cancer (HP:0003003)2.21673852
62Congenital, generalized hypertrichosis (HP:0004540)2.18731977
63Absent thumb (HP:0009777)2.18317041
64Pendular nystagmus (HP:0012043)2.18178333
65Keratoconus (HP:0000563)2.16507416
66Increased corneal curvature (HP:0100692)2.16507416
67Autoimmune thrombocytopenia (HP:0001973)2.14127774
68Abnormality of the prostate (HP:0008775)2.10416733
69Macrocytic anemia (HP:0001972)2.09898011
70Septo-optic dysplasia (HP:0100842)2.09768651
71Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08911844
72Nephronophthisis (HP:0000090)2.06672066
73Stomatitis (HP:0010280)2.04883200
74Muscle fiber atrophy (HP:0100295)2.03580335
75Chronic sinusitis (HP:0011109)1.99573013
76Exertional dyspnea (HP:0002875)1.99313799
77Supernumerary spleens (HP:0009799)1.98618995
78Encephalitis (HP:0002383)1.95117171
79Hypoalbuminemia (HP:0003073)1.94979519
80Abnormal albumin level (HP:0012116)1.94979519
81Dynein arm defect of respiratory motile cilia (HP:0012255)1.94566875
82Absent/shortened dynein arms (HP:0200106)1.94566875
83Hyperglycinemia (HP:0002154)1.92843691
84Lethargy (HP:0001254)1.90899481
85Polydipsia (HP:0001959)1.90868360
86Abnormal drinking behavior (HP:0030082)1.90868360
87Granulocytopenia (HP:0001913)1.90709510
88Respiratory failure (HP:0002878)1.89211975
89Abnormality of the renal cortex (HP:0011035)1.88725739
90Dicarboxylic aciduria (HP:0003215)1.88493062
91Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88493062
92Leukocytosis (HP:0001974)1.85232692
93Prostate neoplasm (HP:0100787)1.83239436
94Agammaglobulinemia (HP:0004432)1.82865579
95Type I transferrin isoform profile (HP:0003642)1.82018269
96Recurrent bronchitis (HP:0002837)1.79073884
97Abnormal respiratory motile cilium morphology (HP:0005938)1.78094243
98Abnormal respiratory epithelium morphology (HP:0012253)1.78094243
99Aplasia/hypoplasia of the uterus (HP:0008684)1.77662353
100Chronic diarrhea (HP:0002028)1.76395750

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.99183180
2KDR3.91924697
3TESK23.85987390
4TXK3.27390722
5TLK13.18502753
6ZAK2.52117796
7ADRBK22.50698258
8STK162.47474350
9VRK22.46690653
10GRK12.40365045
11MAP4K22.28291895
12FRK2.20288034
13WNK42.16566344
14ITK2.06328341
15MAP4K12.05661574
16CDK191.90663054
17TEC1.65336204
18NUAK11.64740368
19PASK1.64694704
20TAOK31.60959640
21MAP3K121.56874235
22VRK11.34360495
23SYK1.29459994
24BTK1.27503530
25TIE11.21222568
26CAMKK21.21000020
27PIK3CG1.15955823
28GRK61.14352727
29FES1.14122790
30PINK11.13769530
31IKBKB1.11633588
32WNK31.08486836
33KIT1.07274844
34EIF2AK31.02539277
35LIMK11.02366193
36BUB11.01938794
37MAP2K61.00777111
38RPS6KA50.99978316
39PRKCQ0.98671940
40MUSK0.97198457
41BMPR1B0.90498255
42MAP3K110.89884860
43PIK3CA0.87444557
44CAMKK10.86424735
45LCK0.85863257
46EIF2AK10.85721624
47IKBKE0.83530244
48DYRK20.83074871
49ADRBK10.81671834
50INSRR0.78747756
51STK390.77991792
52MAPKAPK30.75225179
53SRPK10.75159734
54LYN0.69232922
55MST40.68775434
56DAPK10.68652118
57PLK20.65536412
58OXSR10.64950623
59NME10.64022939
60DAPK20.63930501
61EPHB20.61141851
62GRK50.60651249
63MYLK0.56759504
64PIM20.55574774
65MAP3K90.54370137
66OBSCN0.53960107
67TNK20.53280098
68MATK0.51955081
69MAPKAPK50.51785882
70SCYL20.51332321
71LRRK20.50851060
72CAMK10.50820183
73ARAF0.50733993
74CSNK1G30.50475846
75SIK20.48515685
76EPHA40.43770296
77MAPK150.43718043
78PHKG20.41992371
79PHKG10.41992371
80CSK0.41834101
81PLK40.41321621
82ZAP700.40670464
83MAPK130.40346864
84PRKACA0.39540200
85PRKCA0.39462010
86CSNK1G20.39272501
87CSNK2A20.39249614
88MAP3K130.39163160
89GRK70.38819523
90AURKA0.37927433
91TSSK60.37462111
92DAPK30.37346493
93AURKB0.36485602
94CSNK2A10.36114213
95IGF1R0.34621279
96CSNK1G10.34611953
97NME20.34553165
98ATR0.34470685
99PDK20.32714173
100CSNK1A1L0.31487760

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.22128055
2Proteasome_Homo sapiens_hsa030503.74205464
3Oxidative phosphorylation_Homo sapiens_hsa001903.58794921
4Primary immunodeficiency_Homo sapiens_hsa053403.51776279
5Parkinsons disease_Homo sapiens_hsa050122.92558854
6Allograft rejection_Homo sapiens_hsa053302.75820758
7Autoimmune thyroid disease_Homo sapiens_hsa053202.73218179
8Graft-versus-host disease_Homo sapiens_hsa053322.68345883
9RNA polymerase_Homo sapiens_hsa030202.27706759
10Asthma_Homo sapiens_hsa053102.25690701
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.18864381
12Antigen processing and presentation_Homo sapiens_hsa046122.17429321
13Phototransduction_Homo sapiens_hsa047442.16517778
14Protein export_Homo sapiens_hsa030602.11792612
15Type I diabetes mellitus_Homo sapiens_hsa049402.02735438
16Alzheimers disease_Homo sapiens_hsa050101.94080579
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82584422
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80693980
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.80665365
20Huntingtons disease_Homo sapiens_hsa050161.79956822
21Cardiac muscle contraction_Homo sapiens_hsa042601.61540824
22Hematopoietic cell lineage_Homo sapiens_hsa046401.60840332
23Linoleic acid metabolism_Homo sapiens_hsa005911.58230041
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50756372
25Homologous recombination_Homo sapiens_hsa034401.45648057
26One carbon pool by folate_Homo sapiens_hsa006701.45632022
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32540859
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30248701
29RNA degradation_Homo sapiens_hsa030181.20690760
30Pyrimidine metabolism_Homo sapiens_hsa002401.18495640
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18483817
32Propanoate metabolism_Homo sapiens_hsa006401.18257606
33Rheumatoid arthritis_Homo sapiens_hsa053231.13021583
34Fanconi anemia pathway_Homo sapiens_hsa034601.12375161
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09311708
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01098286
37Nitrogen metabolism_Homo sapiens_hsa009100.99016239
38Purine metabolism_Homo sapiens_hsa002300.93566655
39DNA replication_Homo sapiens_hsa030300.93269321
40Caffeine metabolism_Homo sapiens_hsa002320.91656090
41Peroxisome_Homo sapiens_hsa041460.91088817
42Nucleotide excision repair_Homo sapiens_hsa034200.89803542
43Arachidonic acid metabolism_Homo sapiens_hsa005900.89538417
44Mismatch repair_Homo sapiens_hsa034300.87966331
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87530608
46Basal transcription factors_Homo sapiens_hsa030220.85968408
47Sulfur metabolism_Homo sapiens_hsa009200.84211065
48Chemical carcinogenesis_Homo sapiens_hsa052040.84084954
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82780807
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82280032
51T cell receptor signaling pathway_Homo sapiens_hsa046600.80179293
52Non-homologous end-joining_Homo sapiens_hsa034500.79986824
53Retinol metabolism_Homo sapiens_hsa008300.79623827
54Base excision repair_Homo sapiens_hsa034100.77737766
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77080227
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75990810
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.75009206
58Spliceosome_Homo sapiens_hsa030400.74905120
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74117028
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74043716
61Butanoate metabolism_Homo sapiens_hsa006500.71858740
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71156320
63Systemic lupus erythematosus_Homo sapiens_hsa053220.70904543
64Olfactory transduction_Homo sapiens_hsa047400.70825654
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66814448
66Viral myocarditis_Homo sapiens_hsa054160.65006918
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61546878
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.61413866
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.60577964
70Tryptophan metabolism_Homo sapiens_hsa003800.59755864
71Collecting duct acid secretion_Homo sapiens_hsa049660.58701149
72RNA transport_Homo sapiens_hsa030130.57391964
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57149984
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56581813
75Metabolic pathways_Homo sapiens_hsa011000.55945084
76Staphylococcus aureus infection_Homo sapiens_hsa051500.55350976
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50844696
78Ether lipid metabolism_Homo sapiens_hsa005650.50313789
79Sulfur relay system_Homo sapiens_hsa041220.49418875
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.46689595
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.45330993
82Measles_Homo sapiens_hsa051620.44028553
83Fat digestion and absorption_Homo sapiens_hsa049750.42673626
84Nicotine addiction_Homo sapiens_hsa050330.40955888
85Taste transduction_Homo sapiens_hsa047420.40873672
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40870304
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40205101
88Morphine addiction_Homo sapiens_hsa050320.39611461
89Herpes simplex infection_Homo sapiens_hsa051680.37613880
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33429845
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33383716
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.32416946
93Ovarian steroidogenesis_Homo sapiens_hsa049130.31227891
94Epstein-Barr virus infection_Homo sapiens_hsa051690.28271838
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26515071
96Glutathione metabolism_Homo sapiens_hsa004800.24356226
97Selenocompound metabolism_Homo sapiens_hsa004500.24066057
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.16501889
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15332838
100Regulation of autophagy_Homo sapiens_hsa041400.15166364

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