ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular response to ATP (GO:0071318)	7.97541714
2	protein K63-linked deubiquitination (GO:0070536)	6.08567062
3	UDP-N-acetylglucosamine metabolic process (GO:0006047)	6.01619678
4	rRNA catabolic process (GO:0016075)	5.73353591
5	maturation of SSU-rRNA (GO:0030490)	5.58786157
6	leukotriene biosynthetic process (GO:0019370)	5.55801673
7	glomerular visceral epithelial cell development (GO:0072015)	5.53665945
8	maturation of 5.8S rRNA (GO:0000460)	4.87438919
9	serotonin receptor signaling pathway (GO:0007210)	4.84130019
10	L-fucose catabolic process (GO:0042355)	4.83287373
11	fucose catabolic process (GO:0019317)	4.83287373
12	L-fucose metabolic process (GO:0042354)	4.83287373
13	glomerular epithelial cell development (GO:0072310)	4.81266492
14	resolution of meiotic recombination intermediates (GO:0000712)	4.45631679
15	neurotransmitter catabolic process (GO:0042135)	4.35787857
16	protein K48-linked deubiquitination (GO:0071108)	4.34748913
17	cellular ketone body metabolic process (GO:0046950)	4.34449475
18	activated T cell proliferation (GO:0050798)	4.22636266
19	single strand break repair (GO:0000012)	4.16837386
20	mannosylation (GO:0097502)	4.11447734
21	isoprenoid biosynthetic process (GO:0008299)	4.05000532
22	ncRNA catabolic process (GO:0034661)	3.98867069
23	L-alpha-amino acid transmembrane transport (GO:1902475)	3.95683954
24	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.91510918
25	response to pheromone (GO:0019236)	3.91345084
26	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.89556648
27	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.87281213
28	ketone body metabolic process (GO:1902224)	3.78857452
29	peripheral nervous system neuron development (GO:0048935)	3.73262988
30	purine nucleotide salvage (GO:0032261)	3.72348297
31	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.62453746
32	somite development (GO:0061053)	3.60811466
33	heme transport (GO:0015886)	3.59812204
34	leukotriene metabolic process (GO:0006691)	3.55594910
35	substrate-independent telencephalic tangential migration (GO:0021826)	3.49470004
36	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.49470004
37	negative regulation of organelle assembly (GO:1902116)	3.45834745
38	fatty acid derivative biosynthetic process (GO:1901570)	3.39603647
39	icosanoid biosynthetic process (GO:0046456)	3.39603647
40	RNA localization (GO:0006403)	3.38063510
41	viral mRNA export from host cell nucleus (GO:0046784)	3.36442055
42	regulation of mitotic spindle checkpoint (GO:1903504)	3.35443110
43	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.35443110
44	negative regulation of telomere maintenance (GO:0032205)	3.35415653
45	organelle membrane fusion (GO:0090174)	3.34529633
46	response to ATP (GO:0033198)	3.33272651
47	epithelial cilium movement (GO:0003351)	3.31717586
48	positive regulation of protein homodimerization activity (GO:0090073)	3.28650561
49	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.25504389
50	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.24603733
51	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.18235749
52	nonmotile primary cilium assembly (GO:0035058)	3.13270088
53	regulation of telomere maintenance (GO:0032204)	3.09738656
54	necroptotic process (GO:0070266)	3.07636199
55	histone mRNA catabolic process (GO:0071044)	3.02657251
56	negative regulation of neurological system process (GO:0031645)	2.99544605
57	left/right axis specification (GO:0070986)	2.98301175
58	protein polyglutamylation (GO:0018095)	2.96433473
59	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.93041537
60	negative regulation of NF-kappaB import into nucleus (GO:0042347)	2.89751866
61	inositol metabolic process (GO:0006020)	2.87671292
62	natural killer cell activation involved in immune response (GO:0002323)	2.86184614
63	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.85918263
64	nuclear pore organization (GO:0006999)	2.84296183
65	protein ADP-ribosylation (GO:0006471)	2.83065662
66	detection of light stimulus involved in sensory perception (GO:0050962)	2.82050336
67	detection of light stimulus involved in visual perception (GO:0050908)	2.82050336
68	iron coordination entity transport (GO:1901678)	2.80198812
69	histone H3-K9 methylation (GO:0051567)	2.75878792
70	retinal cone cell development (GO:0046549)	2.74957390
71	regulation of response to tumor cell (GO:0002834)	2.73806267
72	positive regulation of response to tumor cell (GO:0002836)	2.73806267
73	positive regulation of immune response to tumor cell (GO:0002839)	2.73806267
74	regulation of immune response to tumor cell (GO:0002837)	2.73806267
75	adenosine metabolic process (GO:0046085)	2.73147199
76	parturition (GO:0007567)	2.72241629
77	fucosylation (GO:0036065)	2.69435850
78	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.69336768
79	positive regulation of vesicle fusion (GO:0031340)	2.64839047
80	neural tube formation (GO:0001841)	2.64763468
81	cilium or flagellum-dependent cell motility (GO:0001539)	2.64354546
82	glutathione metabolic process (GO:0006749)	2.63913576
83	paraxial mesoderm development (GO:0048339)	2.58955242
84	necrotic cell death (GO:0070265)	2.58266378
85	sequestering of metal ion (GO:0051238)	2.57882951
86	NAD biosynthetic process (GO:0009435)	2.57514273
87	lactate metabolic process (GO:0006089)	2.56964256
88	positive regulation of glycolytic process (GO:0045821)	2.55878134
89	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.55307667
90	arginine metabolic process (GO:0006525)	2.55074332
91	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.52529189
92	glycerol metabolic process (GO:0006071)	2.52522936
93	regulation of action potential (GO:0098900)	2.49333407
94	DNA replication checkpoint (GO:0000076)	2.49273095
95	establishment of protein localization to Golgi (GO:0072600)	2.48493212
96	magnesium ion transport (GO:0015693)	2.46611544
97	dosage compensation (GO:0007549)	2.45290120
98	programmed necrotic cell death (GO:0097300)	2.44975902
99	cysteine metabolic process (GO:0006534)	2.44718238
100	preassembly of GPI anchor in ER membrane (GO:0016254)	2.44562489

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	6.68215089
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.73653475
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.13053632
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.92642977
5	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.88429835
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.64120814
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.58742299
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.35541446
9	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.28082022
10	CBP_20019798_ChIP-Seq_JUKART_Human	2.28082022
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16853822
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.14476971
13	AR_21572438_ChIP-Seq_LNCaP_Human	2.12624060
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.12019196
15	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	2.07537478
16	EWS_26573619_Chip-Seq_HEK293_Human	2.06987933
17	VDR_22108803_ChIP-Seq_LS180_Human	2.04373381
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.04337424
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.99284375
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.98832973
21	P300_19829295_ChIP-Seq_ESCs_Human	1.90480850
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.90008432
23	FUS_26573619_Chip-Seq_HEK293_Human	1.84044509
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.83361956
25	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.80199604
26	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.77170599
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.75934152
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.71910798
29	STAT3_23295773_ChIP-Seq_U87_Human	1.70454722
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.67107888
31	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.66534992
32	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.59310427
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.48564446
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.46271138
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45491873
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44051756
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44051756
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42394426
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.38513017
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.38270458
41	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.37585291
42	AR_20517297_ChIP-Seq_VCAP_Human	1.36150591
43	TCF4_23295773_ChIP-Seq_U87_Human	1.36094253
44	REST_21632747_ChIP-Seq_MESCs_Mouse	1.35989327
45	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.34072793
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.32849723
47	DROSHA_22980978_ChIP-Seq_HELA_Human	1.32590984
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28334481
49	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25514384
50	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24632338
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22500035
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22500035
53	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21109333
54	ELK1_19687146_ChIP-ChIP_HELA_Human	1.20801620
55	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.20117045
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18657937
57	NCOR_22424771_ChIP-Seq_293T_Human	1.17948872
58	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14124296
59	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13743630
60	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.13342148
61	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09093401
62	ERA_21632823_ChIP-Seq_H3396_Human	1.08223038
63	AR_25329375_ChIP-Seq_VCAP_Human	1.07100014
64	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06424630
65	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05789671
66	VDR_23849224_ChIP-Seq_CD4+_Human	1.04096312
67	IRF1_19129219_ChIP-ChIP_H3396_Human	1.02983117
68	TAF2_19829295_ChIP-Seq_ESCs_Human	1.02409019
69	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.02018322
70	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.01004325
71	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.00933658
72	OCT4_20526341_ChIP-Seq_ESCs_Human	1.00797640
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00141358
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00082453
75	VDR_24787735_ChIP-Seq_THP-1_Human	0.99278050
76	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98984995
77	NFYB_21822215_ChIP-Seq_K562_Human	0.98705846
78	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.97042019
79	TCF4_22108803_ChIP-Seq_LS180_Human	0.95147986
80	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.94396761
81	TP53_16413492_ChIP-PET_HCT116_Human	0.94071921
82	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94013242
83	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93213433
84	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.92385560
85	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.92289304
86	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.92076301
87	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.91504263
88	GATA3_26560356_Chip-Seq_TH1_Human	0.90437073
89	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.89618979
90	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.88834516
91	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.88434687
92	NFYA_21822215_ChIP-Seq_K562_Human	0.88022097
93	NANOG_20526341_ChIP-Seq_ESCs_Human	0.87577496
94	RAC3_21632823_ChIP-Seq_H3396_Human	0.86955317
95	MYC_19829295_ChIP-Seq_ESCs_Human	0.86355326
96	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.85755049
97	SMRT_27268052_Chip-Seq_Bcells_Human	0.85340502
98	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.85169081
99	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.84961240
100	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.84755595

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003045_fibrosis	3.65190044
2	MP0002163_abnormal_gland_morphology	3.46313529
3	MP0003890_abnormal_embryonic-extraembry	3.19005427
4	MP0003693_abnormal_embryo_hatching	2.84406532
5	MP0002102_abnormal_ear_morphology	2.72653138
6	MP0008875_abnormal_xenobiotic_pharmacok	2.59040196
7	MP0003787_abnormal_imprinting	2.57347753
8	MP0006292_abnormal_olfactory_placode	2.52480681
9	MP0000569_abnormal_digit_pigmentation	2.47303676
10	MP0002822_catalepsy	2.44854962
11	MP0001968_abnormal_touch/_nociception	2.43176231
12	MP0003183_abnormal_peptide_metabolism	2.41539471
13	MP0008877_abnormal_DNA_methylation	2.29336080
14	MP0002736_abnormal_nociception_after	2.26244326
15	MP0005379_endocrine/exocrine_gland_phen	2.23238015
16	MP0004142_abnormal_muscle_tone	2.20371867
17	MP0005670_abnormal_white_adipose	2.07433601
18	MP0002837_dystrophic_cardiac_calcinosis	2.05684198
19	MP0003646_muscle_fatigue	2.03820594
20	MP0004145_abnormal_muscle_electrophysio	1.98863083
21	MP0004084_abnormal_cardiac_muscle	1.90225518
22	MP0001984_abnormal_olfaction	1.76525561
23	MP0000470_abnormal_stomach_morphology	1.70768450
24	MP0005551_abnormal_eye_electrophysiolog	1.63918265
25	MP0002735_abnormal_chemical_nociception	1.59693642
26	MP0005083_abnormal_biliary_tract	1.58893474
27	MP0001293_anophthalmia	1.57658207
28	MP0002234_abnormal_pharynx_morphology	1.57566661
29	MP0008775_abnormal_heart_ventricle	1.44863026
30	MP0005076_abnormal_cell_differentiation	1.37460105
31	MP0005220_abnormal_exocrine_pancreas	1.37219783
32	MP0001905_abnormal_dopamine_level	1.37088205
33	MP0005646_abnormal_pituitary_gland	1.35905315
34	MP0000383_abnormal_hair_follicle	1.34438148
35	MP0005410_abnormal_fertilization	1.33761884
36	MP0006276_abnormal_autonomic_nervous	1.33110918
37	MP0004147_increased_porphyrin_level	1.31775031
38	MP0002168_other_aberrant_phenotype	1.30814935
39	MP0001502_abnormal_circadian_rhythm	1.27678045
40	MP0000613_abnormal_salivary_gland	1.23235678
41	MP0009745_abnormal_behavioral_response	1.21110234
42	MP0002160_abnormal_reproductive_system	1.20585317
43	MP0005084_abnormal_gallbladder_morpholo	1.18880721
44	MP0004036_abnormal_muscle_relaxation	1.17819686
45	MP0008995_early_reproductive_senescence	1.15504339
46	MP0008569_lethality_at_weaning	1.12955045
47	MP0002067_abnormal_sensory_capabilities	1.12400360
48	MP0008872_abnormal_physiological_respon	1.11351417
49	MP0002733_abnormal_thermal_nociception	1.09804876
50	MP0008961_abnormal_basal_metabolism	1.08649771
51	MP0005645_abnormal_hypothalamus_physiol	1.06655833
52	MP0005386_behavior/neurological_phenoty	1.04467249
53	MP0004924_abnormal_behavior	1.04467249
54	MP0001986_abnormal_taste_sensitivity	1.04031265
55	MP0003195_calcinosis	1.03916140
56	MP0009046_muscle_twitch	1.03241093
57	MP0002572_abnormal_emotion/affect_behav	1.00252785
58	MP0005395_other_phenotype	1.00063775
59	MP0006072_abnormal_retinal_apoptosis	0.99460149
60	MP0003300_gastrointestinal_ulcer	0.98839642
61	MP0001835_abnormal_antigen_presentation	0.95976688
62	MP0005332_abnormal_amino_acid	0.94790694
63	MP0002166_altered_tumor_susceptibility	0.94676152
64	MP0002272_abnormal_nervous_system	0.94446375
65	MP0004885_abnormal_endolymph	0.94099314
66	MP0003718_maternal_effect	0.93869528
67	MP0000013_abnormal_adipose_tissue	0.92778309
68	MP0003638_abnormal_response/metabolism_	0.91255741
69	MP0001486_abnormal_startle_reflex	0.90545009
70	MP0002332_abnormal_exercise_endurance	0.90483089
71	MP0005389_reproductive_system_phenotype	0.90085707
72	MP0002282_abnormal_trachea_morphology	0.85250514
73	MP0000631_abnormal_neuroendocrine_gland	0.83615400
74	MP0004484_altered_response_of	0.83396636
75	MP0001501_abnormal_sleep_pattern	0.82665727
76	MP0003943_abnormal_hepatobiliary_system	0.82085125
77	MP0001663_abnormal_digestive_system	0.80901179
78	MP0002229_neurodegeneration	0.79316255
79	MP0002928_abnormal_bile_duct	0.79205155
80	MP0002557_abnormal_social/conspecific_i	0.78628917
81	MP0004215_abnormal_myocardial_fiber	0.78239291
82	MP0000427_abnormal_hair_cycle	0.77563729
83	MP0001440_abnormal_grooming_behavior	0.77270566
84	MP0002752_abnormal_somatic_nervous	0.76942054
85	MP0005253_abnormal_eye_physiology	0.76637830
86	MP0001970_abnormal_pain_threshold	0.76496886
87	MP0002064_seizures	0.76350766
88	MP0005195_abnormal_posterior_eye	0.75677397
89	MP0003122_maternal_imprinting	0.74061315
90	MP0005499_abnormal_olfactory_system	0.73982330
91	MP0005394_taste/olfaction_phenotype	0.73982330
92	MP0005671_abnormal_response_to	0.73727591
93	MP0009764_decreased_sensitivity_to	0.72121600
94	MP0003698_abnormal_male_reproductive	0.69497852
95	MP0001929_abnormal_gametogenesis	0.67596222
96	MP0002233_abnormal_nose_morphology	0.65710245
97	MP0005387_immune_system_phenotype	0.64610430
98	MP0001790_abnormal_immune_system	0.64610430
99	MP0008789_abnormal_olfactory_epithelium	0.64574624
100	MP0002693_abnormal_pancreas_physiology	0.63574882

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoproteinemia (HP:0003075)	5.41905655
2	Methylmalonic acidemia (HP:0002912)	5.33940565
3	Reduced antithrombin III activity (HP:0001976)	4.83406902
4	Abnormality of DNA repair (HP:0003254)	4.77709809
5	Methylmalonic aciduria (HP:0012120)	4.24771027
6	Stomatitis (HP:0010280)	4.12853479
7	Type 2 muscle fiber atrophy (HP:0003554)	4.05576280
8	Abnormality of the pons (HP:0007361)	4.00595723
9	Type I transferrin isoform profile (HP:0003642)	3.88487702
10	Elevated erythrocyte sedimentation rate (HP:0003565)	3.74025953
11	Muscle fiber atrophy (HP:0100295)	3.62898554
12	Hypoplasia of the pons (HP:0012110)	3.54644350
13	Abnormality of homocysteine metabolism (HP:0010919)	3.43351800
14	Homocystinuria (HP:0002156)	3.43351800
15	Atonic seizures (HP:0010819)	3.32672805
16	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.14345204
17	Papilledema (HP:0001085)	3.10678571
18	Absent thumb (HP:0009777)	3.02112360
19	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.98943365
20	Absent/shortened dynein arms (HP:0200106)	2.98943365
21	Pancreatic fibrosis (HP:0100732)	2.89314498
22	Febrile seizures (HP:0002373)	2.86116794
23	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.85474671
24	Abnormality of the renal cortex (HP:0011035)	2.84913352
25	Diastasis recti (HP:0001540)	2.82312312
26	Chronic hepatic failure (HP:0100626)	2.78271292
27	Molar tooth sign on MRI (HP:0002419)	2.74425156
28	Abnormality of midbrain morphology (HP:0002418)	2.74425156
29	Attenuation of retinal blood vessels (HP:0007843)	2.74205340
30	Exotropia (HP:0000577)	2.62044873
31	Pancreatic cysts (HP:0001737)	2.60891559
32	Duplicated collecting system (HP:0000081)	2.60569428
33	Abnormality of vitamin B metabolism (HP:0004340)	2.57138979
34	Abnormal protein glycosylation (HP:0012346)	2.56903169
35	Abnormal glycosylation (HP:0012345)	2.56903169
36	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.56903169
37	Abnormal protein N-linked glycosylation (HP:0012347)	2.56903169
38	Prolonged QT interval (HP:0001657)	2.53624170
39	Hypochromic microcytic anemia (HP:0004840)	2.52161784
40	Myopathic facies (HP:0002058)	2.51247413
41	Impulsivity (HP:0100710)	2.51037856
42	Gaze-evoked nystagmus (HP:0000640)	2.50994176
43	Progressive cerebellar ataxia (HP:0002073)	2.50273755
44	Pendular nystagmus (HP:0012043)	2.40355492
45	Facial diplegia (HP:0001349)	2.39433329
46	Abnormality of the renal collecting system (HP:0004742)	2.37731678
47	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.35710482
48	Abnormality of the neuromuscular junction (HP:0003398)	2.35613547
49	Fatigable weakness (HP:0003473)	2.35613547
50	Congenital stationary night blindness (HP:0007642)	2.35239382
51	Abnormal drinking behavior (HP:0030082)	2.33170258
52	Polydipsia (HP:0001959)	2.33170258
53	Macular degeneration (HP:0000608)	2.29196893
54	Meckel diverticulum (HP:0002245)	2.28987213
55	Abnormality of the ileum (HP:0001549)	2.28153231
56	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.27021101
57	Clubbing of toes (HP:0100760)	2.26668430
58	Asplenia (HP:0001746)	2.26489411
59	Inability to walk (HP:0002540)	2.24648565
60	Increased corneal curvature (HP:0100692)	2.24314047
61	Keratoconus (HP:0000563)	2.24314047
62	High pitched voice (HP:0001620)	2.19958874
63	Tubular atrophy (HP:0000092)	2.19077224
64	Progressive inability to walk (HP:0002505)	2.18607259
65	Duodenal stenosis (HP:0100867)	2.17498347
66	Small intestinal stenosis (HP:0012848)	2.17498347
67	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.15544011
68	Oligohydramnios (HP:0001562)	2.10098260
69	Abnormal rod and cone electroretinograms (HP:0008323)	2.08586668
70	True hermaphroditism (HP:0010459)	2.06123503
71	Abnormality of the renal medulla (HP:0100957)	2.04065341
72	Weak cry (HP:0001612)	2.02992071
73	Dialeptic seizures (HP:0011146)	2.02816905
74	Abnormality of the preputium (HP:0100587)	2.00764436
75	Oligodactyly (hands) (HP:0001180)	2.00565620
76	Type II lissencephaly (HP:0007260)	1.99182911
77	Esophageal atresia (HP:0002032)	1.97240781
78	Polyuria (HP:0000103)	1.96302624
79	Focal seizures (HP:0007359)	1.92981826
80	Oligomenorrhea (HP:0000876)	1.92362584
81	Absent speech (HP:0001344)	1.92198885
82	Tubulointerstitial abnormality (HP:0001969)	1.91477364
83	Decreased central vision (HP:0007663)	1.90110577
84	Abnormality of the carotid arteries (HP:0005344)	1.89519761
85	Ketoacidosis (HP:0001993)	1.87346977
86	Poor coordination (HP:0002370)	1.85268293
87	High anterior hairline (HP:0009890)	1.84872298
88	Hip dysplasia (HP:0001385)	1.84204719
89	Peritonitis (HP:0002586)	1.83524707
90	Ectopic kidney (HP:0000086)	1.82858590
91	Anencephaly (HP:0002323)	1.82152437
92	Nephronophthisis (HP:0000090)	1.81087161
93	Cerebral hypomyelination (HP:0006808)	1.79542254
94	Cystic liver disease (HP:0006706)	1.79232456
95	Tubulointerstitial fibrosis (HP:0005576)	1.75227812
96	Abnormality of chromosome stability (HP:0003220)	1.73735180
97	Abnormal EKG (HP:0003115)	1.73483730
98	Supernumerary spleens (HP:0009799)	1.73470928
99	Stenosis of the external auditory canal (HP:0000402)	1.73393819
100	Easy fatigability (HP:0003388)	1.73386265

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.68532874
2	STK16	4.25725485
3	FRK	4.01331978
4	ZAK	3.17655074
5	BMPR1B	3.08651566
6	MKNK1	2.99129459
7	EIF2AK3	2.74480696
8	TLK1	2.70130250
9	MAPKAPK5	2.54061710
10	CAMKK2	2.53248129
11	PIK3CG	2.50303897
12	NEK9	2.42971702
13	TAOK3	2.23178947
14	BCKDK	2.01255493
15	ADRBK2	1.95083454
16	OXSR1	1.87626363
17	EPHB2	1.87167945
18	MAP2K6	1.74024761
19	TEC	1.65466769
20	TNK2	1.62548050
21	MAP3K13	1.59849973
22	IKBKE	1.54377515
23	OBSCN	1.53419854
24	CDK19	1.39423046
25	GRK1	1.35420195
26	PHKG2	1.26174720
27	PHKG1	1.26174720
28	WNK3	1.25200228
29	IKBKB	1.21467370
30	TAF1	1.19462568
31	CSNK1A1L	1.05725439
32	ITK	1.05551394
33	TIE1	1.03135865
34	RPS6KA5	0.99933667
35	MAP3K7	0.90054868
36	AKT3	0.89819696
37	MAPK13	0.89670768
38	STK39	0.86815733
39	FGFR2	0.83459703
40	CAMKK1	0.82953805
41	PRKCE	0.80031854
42	SYK	0.70683923
43	TRIM28	0.70357297
44	ZAP70	0.69588526
45	TNIK	0.69057105
46	RPS6KB2	0.68522471
47	JAK3	0.67834029
48	CAMK1	0.64695480
49	PLK4	0.62976335
50	ERBB3	0.62530031
51	MET	0.60678383
52	VRK1	0.59268202
53	KIT	0.57012090
54	BTK	0.55830539
55	FES	0.55312656
56	MAP3K4	0.54989215
57	CHEK2	0.54857812
58	MAPK7	0.54848285
59	PLK2	0.54179495
60	PLK3	0.53880098
61	MAPK10	0.53861124
62	CAMK1D	0.53746730
63	BLK	0.51039030
64	STK11	0.50928700
65	CAMK4	0.49590703
66	NUAK1	0.49474944
67	CAMK2A	0.48957494
68	CSNK1D	0.46964822
69	NME1	0.46710560
70	PIM1	0.46497720
71	CSNK1A1	0.45480488
72	PINK1	0.45403628
73	WNK1	0.44836978
74	INSRR	0.44590324
75	GRK5	0.43404119
76	PLK1	0.42883017
77	WNK4	0.42401417
78	DYRK1B	0.42259553
79	ADRBK1	0.42042046
80	CAMK1G	0.40951766
81	PRKAA2	0.39844804
82	ATM	0.39057674
83	BRD4	0.38726450
84	MAP3K6	0.38190667
85	BRSK2	0.38179122
86	PRKDC	0.38140384
87	CSNK1G1	0.37231538
88	NTRK3	0.36511527
89	MARK1	0.34469108
90	ATR	0.34000817
91	PRKAA1	0.32422891
92	BCR	0.32166309
93	MST4	0.32006715
94	CSNK1G3	0.31672965
95	PRKACA	0.31428059
96	AURKB	0.31194455
97	RPS6KA6	0.29798036
98	PRKCQ	0.29136885
99	PTK2B	0.27650295
100	CHUK	0.27290943

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Graft-versus-host disease_Homo sapiens_hsa05332	3.40540327
2	Taste transduction_Homo sapiens_hsa04742	3.13956449
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.04974367
4	Nicotine addiction_Homo sapiens_hsa05033	2.67071234
5	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.66223581
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.64078962
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.50199215
8	Asthma_Homo sapiens_hsa05310	2.46668244
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.39947147
10	Phototransduction_Homo sapiens_hsa04744	2.31331827
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.13293420
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.13256538
13	Allograft rejection_Homo sapiens_hsa05330	2.05826991
14	Propanoate metabolism_Homo sapiens_hsa00640	2.03283264
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.98254598
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.97077143
17	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.90000934
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.85555960
19	Type I diabetes mellitus_Homo sapiens_hsa04940	1.81151352
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80371950
21	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.67391306
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.64741608
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.60508913
24	Antigen processing and presentation_Homo sapiens_hsa04612	1.58580805
25	Butanoate metabolism_Homo sapiens_hsa00650	1.55263828
26	RNA degradation_Homo sapiens_hsa03018	1.54275504
27	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.49462631
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.45481769
29	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.43899629
30	ABC transporters_Homo sapiens_hsa02010	1.42698763
31	Histidine metabolism_Homo sapiens_hsa00340	1.42661736
32	Serotonergic synapse_Homo sapiens_hsa04726	1.39313910
33	One carbon pool by folate_Homo sapiens_hsa00670	1.37700640
34	beta-Alanine metabolism_Homo sapiens_hsa00410	1.36223025
35	Morphine addiction_Homo sapiens_hsa05032	1.36159798
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.33731670
37	RNA transport_Homo sapiens_hsa03013	1.26101603
38	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.24976817
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.07614472
40	Base excision repair_Homo sapiens_hsa03410	1.04135630
41	GABAergic synapse_Homo sapiens_hsa04727	1.00385493
42	Nucleotide excision repair_Homo sapiens_hsa03420	1.00275902
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.96585021
44	Lysine degradation_Homo sapiens_hsa00310	0.95168204
45	Glycerolipid metabolism_Homo sapiens_hsa00561	0.87918984
46	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84298726
47	Salivary secretion_Homo sapiens_hsa04970	0.82317723
48	Arginine and proline metabolism_Homo sapiens_hsa00330	0.81985792
49	Olfactory transduction_Homo sapiens_hsa04740	0.81976661
50	Regulation of autophagy_Homo sapiens_hsa04140	0.81585540
51	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.80796653
52	Insulin secretion_Homo sapiens_hsa04911	0.79431154
53	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.78164608
54	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.78135110
55	Homologous recombination_Homo sapiens_hsa03440	0.78128506
56	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.78017268
57	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.73956641
58	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.72838960
59	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.72681155
60	Viral myocarditis_Homo sapiens_hsa05416	0.68718000
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.66362866
62	Oxidative phosphorylation_Homo sapiens_hsa00190	0.66355518
63	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.66030289
64	Peroxisome_Homo sapiens_hsa04146	0.64734033
65	Fatty acid degradation_Homo sapiens_hsa00071	0.64597498
66	Rheumatoid arthritis_Homo sapiens_hsa05323	0.64192470
67	Nitrogen metabolism_Homo sapiens_hsa00910	0.63703249
68	Leishmaniasis_Homo sapiens_hsa05140	0.63207051
69	Fatty acid elongation_Homo sapiens_hsa00062	0.60866277
70	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.59496584
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54602065
72	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.54364830
73	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.53736015
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.51821849
75	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.50436110
76	Glutamatergic synapse_Homo sapiens_hsa04724	0.49613514
77	VEGF signaling pathway_Homo sapiens_hsa04370	0.49351300
78	Calcium signaling pathway_Homo sapiens_hsa04020	0.49110256
79	Basal transcription factors_Homo sapiens_hsa03022	0.48940171
80	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.47296652
81	Long-term depression_Homo sapiens_hsa04730	0.47107853
82	cAMP signaling pathway_Homo sapiens_hsa04024	0.46256794
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44981166
84	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.43940992
85	Circadian entrainment_Homo sapiens_hsa04713	0.43672314
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39250680
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39101368
88	Ribosome_Homo sapiens_hsa03010	0.37388084
89	Parkinsons disease_Homo sapiens_hsa05012	0.36975751
90	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.35824304
91	Primary immunodeficiency_Homo sapiens_hsa05340	0.35731054
92	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.35529923
93	Circadian rhythm_Homo sapiens_hsa04710	0.35361234
94	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.35195258
95	Chemical carcinogenesis_Homo sapiens_hsa05204	0.35115082
96	Collecting duct acid secretion_Homo sapiens_hsa04966	0.24737390
97	Selenocompound metabolism_Homo sapiens_hsa00450	0.24157316
98	Metabolic pathways_Homo sapiens_hsa01100	0.22537676
99	Tuberculosis_Homo sapiens_hsa05152	0.22147632
100	mRNA surveillance pathway_Homo sapiens_hsa03015	0.21434183

RPL18AP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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