ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of chemokine secretion (GO:0090197)	7.19845375
2	regulation of chemokine secretion (GO:0090196)	6.97815040
3	positive regulation of interleukin-8 secretion (GO:2000484)	6.30978048
4	regulation of antigen processing and presentation (GO:0002577)	5.58451487
5	DNA deamination (GO:0045006)	5.57979252
6	positive regulation of antigen processing and presentation (GO:0002579)	5.56859890
7	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	5.03388462
8	pinocytosis (GO:0006907)	5.00952220
9	regulation of interleukin-8 secretion (GO:2000482)	4.96904293
10	tryptophan metabolic process (GO:0006568)	4.67837367
11	positive regulation of interleukin-1 beta secretion (GO:0050718)	4.42206868
12	positive regulation of interleukin-1 secretion (GO:0050716)	4.18331084
13	GTP biosynthetic process (GO:0006183)	4.12318224
14	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	4.12256267
15	regulation of interleukin-1 beta secretion (GO:0050706)	3.93767141
16	indolalkylamine metabolic process (GO:0006586)	3.83361660
17	regulation of regulatory T cell differentiation (GO:0045589)	3.80958159
18	rRNA catabolic process (GO:0016075)	3.71531332
19	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.68653698
20	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.68653698
21	aggressive behavior (GO:0002118)	3.68385931
22	positive regulation of interleukin-10 production (GO:0032733)	3.65797090
23	positive regulation of activated T cell proliferation (GO:0042104)	3.56463921
24	negative regulation of stress fiber assembly (GO:0051497)	3.54712563
25	response to interferon-beta (GO:0035456)	3.45434574
26	regulation of interleukin-1 secretion (GO:0050704)	3.44848038
27	UTP biosynthetic process (GO:0006228)	3.44315417
28	positive regulation of interleukin-1 beta production (GO:0032731)	3.39502558
29	protein deneddylation (GO:0000338)	3.37413444
30	maturation of 5.8S rRNA (GO:0000460)	3.34339245
31	cullin deneddylation (GO:0010388)	3.27696375
32	UTP metabolic process (GO:0046051)	3.25142555
33	branched-chain amino acid catabolic process (GO:0009083)	3.24172329
34	ATP synthesis coupled proton transport (GO:0015986)	3.18845265
35	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.18845265
36	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.18165744
37	ribosomal small subunit assembly (GO:0000028)	3.16230238
38	myeloid cell activation involved in immune response (GO:0002275)	3.16100565
39	negative regulation of actin filament bundle assembly (GO:0032232)	3.15807108
40	positive regulation of T cell migration (GO:2000406)	3.13879514
41	positive regulation of T cell cytokine production (GO:0002726)	3.12346805
42	immunoglobulin mediated immune response (GO:0016064)	3.12072126
43	purine deoxyribonucleotide catabolic process (GO:0009155)	3.11573128
44	guanosine-containing compound biosynthetic process (GO:1901070)	3.08626360
45	branched-chain amino acid metabolic process (GO:0009081)	3.06874608
46	tryptophan catabolic process (GO:0006569)	3.02879486
47	indole-containing compound catabolic process (GO:0042436)	3.02879486
48	indolalkylamine catabolic process (GO:0046218)	3.02879486
49	B cell mediated immunity (GO:0019724)	2.98769859
50	preassembly of GPI anchor in ER membrane (GO:0016254)	2.97660877
51	positive regulation of interleukin-1 production (GO:0032732)	2.96413940
52	purine nucleotide salvage (GO:0032261)	2.95631067
53	mast cell activation (GO:0045576)	2.93596681
54	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.92432113
55	pseudouridine synthesis (GO:0001522)	2.89261341
56	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.87474064
57	negative regulation of T-helper cell differentiation (GO:0045623)	2.87280897
58	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.87280897
59	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.85475137
60	valine metabolic process (GO:0006573)	2.85244935
61	lysine catabolic process (GO:0006554)	2.84107795
62	lysine metabolic process (GO:0006553)	2.84107795
63	ubiquinone biosynthetic process (GO:0006744)	2.81450518
64	regulation of interleukin-10 production (GO:0032653)	2.80982782
65	mast cell degranulation (GO:0043303)	2.80894027
66	mast cell activation involved in immune response (GO:0002279)	2.80894027
67	cellular response to interferon-beta (GO:0035458)	2.77394068
68	autophagic vacuole fusion (GO:0000046)	2.75670593
69	mitochondrial respiratory chain complex assembly (GO:0033108)	2.75394726
70	CTP metabolic process (GO:0046036)	2.68177609
71	CTP biosynthetic process (GO:0006241)	2.68177609
72	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.67907069
73	regulation of T cell migration (GO:2000404)	2.63462612
74	piRNA metabolic process (GO:0034587)	2.62162961
75	regulation of T-helper 1 cell differentiation (GO:0045625)	2.61486217
76	positive regulation of lamellipodium assembly (GO:0010592)	2.60855894
77	mannosylation (GO:0097502)	2.60536249
78	purine deoxyribonucleotide metabolic process (GO:0009151)	2.58270016
79	positive regulation of lymphocyte migration (GO:2000403)	2.57893295
80	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.52151481
81	relaxation of smooth muscle (GO:0044557)	2.51109306
82	negative regulation of type I interferon production (GO:0032480)	2.49317788
83	negative regulation of mast cell activation (GO:0033004)	2.49181588
84	antigen processing and presentation of endogenous antigen (GO:0019883)	2.48834480
85	neutrophil activation involved in immune response (GO:0002283)	2.48381826
86	indole-containing compound metabolic process (GO:0042430)	2.47792030
87	purine-containing compound salvage (GO:0043101)	2.45909487
88	maturation of SSU-rRNA (GO:0030490)	2.45892643
89	positive regulation of isotype switching (GO:0045830)	2.45400459
90	nucleoside diphosphate phosphorylation (GO:0006165)	2.42706162
91	water-soluble vitamin biosynthetic process (GO:0042364)	2.41685205
92	base-excision repair, AP site formation (GO:0006285)	2.41146885
93	intra-S DNA damage checkpoint (GO:0031573)	2.40750570
94	regulation of B cell apoptotic process (GO:0002902)	2.40626339
95	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.40092653
96	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)	2.38450571
97	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.38420303
98	regulation of interleukin-1 beta production (GO:0032651)	2.38304884
99	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.38011267
100	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	10.8662619

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	4.40557623
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.07647464
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.01575918
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.98720929
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.95881968
6	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.48685707
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.29242882
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.24975604
9	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.21104310
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.99553553
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.96449634
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.66834048
13	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.43644339
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.42800801
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.40870755
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.37800200
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.31273261
18	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.31186366
19	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.26519204
20	IGF1R_20145208_ChIP-Seq_DFB_Human	2.16108161
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.09192491
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.04892422
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.94186996
24	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.90095914
25	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.89107220
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.88563250
27	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.85649722
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.83343407
29	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.79957970
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.78246382
31	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.71028101
32	VDR_22108803_ChIP-Seq_LS180_Human	1.69325437
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.67418919
34	CIITA_25753668_ChIP-Seq_RAJI_Human	1.64504441
35	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.62050604
36	GATA3_26560356_Chip-Seq_TH2_Human	1.58316583
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.57942106
38	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.56416831
39	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.50903853
40	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.48654409
41	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.46163608
42	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.45908086
43	* MYB_26560356_Chip-Seq_TH2_Human	1.37128085
44	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.36426172
45	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.35771726
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35196914
47	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.29420003
48	HTT_18923047_ChIP-ChIP_STHdh_Human	1.29111302
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.26262129
50	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.25277673
51	AR_20517297_ChIP-Seq_VCAP_Human	1.24844280
52	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.22641087
53	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.20875451
54	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.20711328
55	SPI1_23547873_ChIP-Seq_NB4_Human	1.20281791
56	ERG_20517297_ChIP-Seq_VCAP_Human	1.18605877
57	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.17698765
58	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.14632760
59	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.12912797
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10968324
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09157412
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09157412
63	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.09045587
64	* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.08282284
65	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.06229632
66	P53_21459846_ChIP-Seq_SAOS-2_Human	1.05411569
67	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.05260187
68	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.05165189
69	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05093898
70	ERA_21632823_ChIP-Seq_H3396_Human	1.05082864
71	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.04844712
72	NANOG_20526341_ChIP-Seq_ESCs_Human	1.04651433
73	TTF2_22483619_ChIP-Seq_HELA_Human	1.03681977
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03557869
75	EWS_26573619_Chip-Seq_HEK293_Human	1.03329304
76	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.03316239
77	IRF1_19129219_ChIP-ChIP_H3396_Human	1.02730330
78	NCOR_22424771_ChIP-Seq_293T_Human	1.01997781
79	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.00963131
80	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.99377492
81	TP53_22573176_ChIP-Seq_HFKS_Human	0.99096344
82	SCL_19346495_ChIP-Seq_HPC-7_Human	0.99058341
83	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.98725944
84	FUS_26573619_Chip-Seq_HEK293_Human	0.98697110
85	MYC_19829295_ChIP-Seq_ESCs_Human	0.98094592
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97605146
87	GABP_19822575_ChIP-Seq_HepG2_Human	0.96208175
88	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.94219283
89	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94168170
90	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94168170
91	XRN2_22483619_ChIP-Seq_HELA_Human	0.93513271
92	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.89853412
93	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89671868
94	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.89202285
95	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.88568496
96	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.87933676
97	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.87513563
98	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.86626636
99	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.86601976
100	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.85865535

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	3.90089086
2	MP0002148_abnormal_hypersensitivity_rea	3.49069985
3	MP0005646_abnormal_pituitary_gland	3.39313872
4	MP0003787_abnormal_imprinting	2.60149330
5	MP0008058_abnormal_DNA_repair	2.51366189
6	MP0003011_delayed_dark_adaptation	2.48273851
7	MP0002138_abnormal_hepatobiliary_system	2.36567133
8	MP0005464_abnormal_platelet_physiology	2.23947825
9	MP0002006_tumorigenesis	2.14890420
10	MP0002166_altered_tumor_susceptibility	2.06017089
11	MP0002876_abnormal_thyroid_physiology	2.04865997
12	MP0005000_abnormal_immune_tolerance	2.04729057
13	MP0002102_abnormal_ear_morphology	2.00075965
14	MP0009764_decreased_sensitivity_to	2.00002750
15	MP0005084_abnormal_gallbladder_morpholo	1.94246836
16	MP0003724_increased_susceptibility_to	1.82739178
17	MP0005083_abnormal_biliary_tract	1.80601786
18	MP0004885_abnormal_endolymph	1.80296256
19	MP0003186_abnormal_redox_activity	1.77105505
20	MP0005671_abnormal_response_to	1.74564415
21	MP0003436_decreased_susceptibility_to	1.72608798
22	MP0004145_abnormal_muscle_electrophysio	1.68701268
23	MP0008875_abnormal_xenobiotic_pharmacok	1.66682693
24	MP0002837_dystrophic_cardiac_calcinosis	1.66651351
25	MP0008872_abnormal_physiological_respon	1.66623292
26	MP0003646_muscle_fatigue	1.66020074
27	MP0001986_abnormal_taste_sensitivity	1.62792593
28	MP0006072_abnormal_retinal_apoptosis	1.57656337
29	MP0000230_abnormal_systemic_arterial	1.57488949
30	MP0002723_abnormal_immune_serum	1.56337196
31	MP0006082_CNS_inflammation	1.54480578
32	MP0006036_abnormal_mitochondrial_physio	1.52492062
33	MP0006035_abnormal_mitochondrial_morpho	1.51079484
34	MP0001800_abnormal_humoral_immune	1.48503947
35	MP0002452_abnormal_antigen_presenting	1.46989658
36	MP0004808_abnormal_hematopoietic_stem	1.46179749
37	MP0003300_gastrointestinal_ulcer	1.44045837
38	MP0001661_extended_life_span	1.43834256
39	MP0002928_abnormal_bile_duct	1.43090618
40	MP0001968_abnormal_touch/_nociception	1.41965089
41	MP0003283_abnormal_digestive_organ	1.41644563
42	MP0008775_abnormal_heart_ventricle	1.37115563
43	MP0004147_increased_porphyrin_level	1.35112853
44	MP0002420_abnormal_adaptive_immunity	1.35028763
45	MP0009785_altered_susceptibility_to	1.34903682
46	MP0005075_abnormal_melanosome_morpholog	1.34891239
47	MP0001819_abnormal_immune_cell	1.33424387
48	MP0008877_abnormal_DNA_methylation	1.23574386
49	MP0003806_abnormal_nucleotide_metabolis	1.23024698
50	MP0009333_abnormal_splenocyte_physiolog	1.22755240
51	MP0006292_abnormal_olfactory_placode	1.21941508
52	MP0003195_calcinosis	1.21216963
53	MP0010094_abnormal_chromosome_stability	1.19466117
54	MP0003252_abnormal_bile_duct	1.17660390
55	MP0002160_abnormal_reproductive_system	1.17167849
56	MP0005410_abnormal_fertilization	1.16232951
57	MP0010386_abnormal_urinary_bladder	1.15984817
58	MP0002277_abnormal_respiratory_mucosa	1.15465433
59	MP0010368_abnormal_lymphatic_system	1.13955651
60	MP0005025_abnormal_response_to	1.11949276
61	MP0005389_reproductive_system_phenotype	1.11559682
62	MP0005551_abnormal_eye_electrophysiolog	1.10411781
63	MP0003718_maternal_effect	1.07670286
64	MP0000467_abnormal_esophagus_morphology	1.07631680
65	MP0002419_abnormal_innate_immunity	1.07496928
66	MP0008469_abnormal_protein_level	1.07264883
67	MP0001845_abnormal_inflammatory_respons	1.05058216
68	MP0003786_premature_aging	1.02163733
69	MP0002019_abnormal_tumor_incidence	1.00933336
70	MP0010155_abnormal_intestine_physiology	1.00775364
71	MP0001984_abnormal_olfaction	1.00522566
72	MP0009697_abnormal_copulation	0.99135343
73	MP0005319_abnormal_enzyme/_coenzyme	0.95994275
74	MP0008873_increased_physiological_sensi	0.94917392
75	MP0001764_abnormal_homeostasis	0.94570527
76	MP0000716_abnormal_immune_system	0.94525563
77	MP0005595_abnormal_vascular_smooth	0.92951429
78	MP0004215_abnormal_myocardial_fiber	0.92681153
79	MP0005085_abnormal_gallbladder_physiolo	0.91802393
80	MP0002398_abnormal_bone_marrow	0.91593321
81	MP0000372_irregular_coat_pigmentation	0.91219730
82	MP0000689_abnormal_spleen_morphology	0.88845326
83	MP0001756_abnormal_urination	0.88062919
84	MP0003866_abnormal_defecation	0.87806701
85	MP0005253_abnormal_eye_physiology	0.87739217
86	MP0002429_abnormal_blood_cell	0.84688112
87	MP0002736_abnormal_nociception_after	0.84640899
88	MP0005645_abnormal_hypothalamus_physiol	0.84188861
89	MP0001533_abnormal_skeleton_physiology	0.83085536
90	MP0003183_abnormal_peptide_metabolism	0.83076915
91	MP0003763_abnormal_thymus_physiology	0.82766944
92	MP0001919_abnormal_reproductive_system	0.81350357
93	MP0005670_abnormal_white_adipose	0.81138372
94	MP0002163_abnormal_gland_morphology	0.80949827
95	MP0001790_abnormal_immune_system	0.79014923
96	MP0005387_immune_system_phenotype	0.79014923
97	MP0008995_early_reproductive_senescence	0.78075128
98	MP0002933_joint_inflammation	0.77642617
99	MP0002095_abnormal_skin_pigmentation	0.76863076
100	MP0001873_stomach_inflammation	0.74528916

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.51181795
2	Absent/shortened dynein arms (HP:0200106)	4.51181795
3	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.45714852
4	Decreased central vision (HP:0007663)	3.65708786
5	Spontaneous abortion (HP:0005268)	3.39399788
6	Testicular atrophy (HP:0000029)	3.38117842
7	Thrombocytosis (HP:0001894)	3.33944432
8	Elevated erythrocyte sedimentation rate (HP:0003565)	3.27980925
9	Stomach cancer (HP:0012126)	3.27343556
10	Colon cancer (HP:0003003)	3.23909399
11	Pancreatic cysts (HP:0001737)	3.20904539
12	Abolished electroretinogram (ERG) (HP:0000550)	3.18093761
13	Congenital stationary night blindness (HP:0007642)	3.17656883
14	Abnormality of the renal cortex (HP:0011035)	3.17346217
15	Hyperglycinemia (HP:0002154)	3.14683557
16	Hyperglycinuria (HP:0003108)	3.07522463
17	Abnormality of B cell number (HP:0010975)	3.05450551
18	Type 2 muscle fiber atrophy (HP:0003554)	2.93549356
19	Acute necrotizing encephalopathy (HP:0006965)	2.89157091
20	Stomatitis (HP:0010280)	2.86786646
21	Amaurosis fugax (HP:0100576)	2.86385475
22	Opisthotonus (HP:0002179)	2.74967926
23	Abnormal respiratory epithelium morphology (HP:0012253)	2.73378752
24	Abnormal respiratory motile cilium morphology (HP:0005938)	2.73378752
25	Attenuation of retinal blood vessels (HP:0007843)	2.67825234
26	Abnormal mitochondria in muscle tissue (HP:0008316)	2.64257664
27	Facial diplegia (HP:0001349)	2.64024314
28	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.62640968
29	Nephronophthisis (HP:0000090)	2.62389933
30	Panhypogammaglobulinemia (HP:0003139)	2.61850222
31	Abnormality of the prostate (HP:0008775)	2.60476442
32	Degeneration of anterior horn cells (HP:0002398)	2.58421432
33	Abnormality of the anterior horn cell (HP:0006802)	2.58421432
34	Keratoconus (HP:0000563)	2.56950744
35	Increased corneal curvature (HP:0100692)	2.56950744
36	B lymphocytopenia (HP:0010976)	2.56532336
37	Renal cortical cysts (HP:0000803)	2.52920700
38	Abnormality of the renal medulla (HP:0100957)	2.52867734
39	Abnormal ciliary motility (HP:0012262)	2.51631333
40	Metaphyseal dysplasia (HP:0100255)	2.51394600
41	Pancreatic fibrosis (HP:0100732)	2.51053855
42	Progressive macrocephaly (HP:0004481)	2.49847017
43	Autoimmune hemolytic anemia (HP:0001890)	2.47839156
44	Redundant skin (HP:0001582)	2.47036313
45	Abnormality of serine family amino acid metabolism (HP:0010894)	2.45993829
46	Abnormality of glycine metabolism (HP:0010895)	2.45993829
47	Mitochondrial inheritance (HP:0001427)	2.45577608
48	3-Methylglutaconic aciduria (HP:0003535)	2.45302940
49	Tinnitus (HP:0000360)	2.44143873
50	Abnormal biliary tract physiology (HP:0012439)	2.44050329
51	Bile duct proliferation (HP:0001408)	2.44050329
52	Abnormal drinking behavior (HP:0030082)	2.42461985
53	Polydipsia (HP:0001959)	2.42461985
54	Lactic acidosis (HP:0003128)	2.40092515
55	Ketosis (HP:0001946)	2.38208315
56	Cone-rod dystrophy (HP:0000548)	2.37498247
57	Increased CSF lactate (HP:0002490)	2.37307868
58	Muscle fiber atrophy (HP:0100295)	2.36205130
59	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.31217758
60	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.31217758
61	Abnormal number of erythroid precursors (HP:0012131)	2.31162310
62	Agammaglobulinemia (HP:0004432)	2.25562406
63	Increased cerebral lipofuscin (HP:0011813)	2.24856459
64	Acute encephalopathy (HP:0006846)	2.22175765
65	Increased serum lactate (HP:0002151)	2.20846780
66	Dyschromatopsia (HP:0007641)	2.19099829
67	Abnormality of serum amino acid levels (HP:0003112)	2.14419933
68	Prostate neoplasm (HP:0100787)	2.13596457
69	Increased hepatocellular lipid droplets (HP:0006565)	2.13174880
70	Lipid accumulation in hepatocytes (HP:0006561)	2.12413927
71	Optic disc pallor (HP:0000543)	2.11895325
72	Hypothermia (HP:0002045)	2.09811955
73	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.09046569
74	Abnormality of lateral ventricle (HP:0030047)	2.08023765
75	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.03236523
76	Dicarboxylic aciduria (HP:0003215)	2.03236523
77	Abnormality of cells of the erythroid lineage (HP:0012130)	2.02136278
78	Lethargy (HP:0001254)	2.01551811
79	Abnormal respiratory motile cilium physiology (HP:0012261)	2.01500058
80	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.00025044
81	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.99501189
82	Methylmalonic acidemia (HP:0002912)	1.98897016
83	Polyuria (HP:0000103)	1.98798656
84	Renal Fanconi syndrome (HP:0001994)	1.98426301
85	Pancytopenia (HP:0001876)	1.97871359
86	Cerebral edema (HP:0002181)	1.97485143
87	Hepatic necrosis (HP:0002605)	1.96660431
88	Increased intramyocellular lipid droplets (HP:0012240)	1.95383175
89	Palpitations (HP:0001962)	1.95304210
90	Exertional dyspnea (HP:0002875)	1.94671342
91	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.94596383
92	Premature ovarian failure (HP:0008209)	1.94202728
93	Absent phalangeal crease (HP:0006109)	1.93575158
94	Enlarged kidneys (HP:0000105)	1.93117406
95	Hepatocellular necrosis (HP:0001404)	1.92683952
96	Neurodegeneration (HP:0002180)	1.91799512
97	Asplenia (HP:0001746)	1.91422162
98	Malignant hyperthermia (HP:0002047)	1.90888029
99	Ulnar deviation of the wrist (HP:0003049)	1.90458172
100	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.88410190

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	6.22303952
2	KIT	3.41780460
3	MAP3K13	3.02810789
4	TLK1	2.96008565
5	BCKDK	2.50200493
6	FRK	2.28616021
7	PBK	2.06363153
8	MAP2K2	2.03266550
9	STK16	1.98094481
10	TEC	1.95524966
11	NUAK1	1.95302073
12	ZAK	1.90309806
13	TXK	1.88861126
14	EIF2AK1	1.87712772
15	EIF2AK3	1.75720998
16	ACVR1B	1.75352660
17	ITK	1.67456530
18	GRK1	1.63753218
19	RIPK4	1.56440026
20	MAP4K2	1.56421416
21	IKBKE	1.55883788
22	IKBKB	1.55860029
23	ADRBK2	1.50321357
24	ZAP70	1.49041828
25	MAP4K1	1.48393200
26	TNK2	1.47131497
27	MAP3K6	1.41987227
28	TBK1	1.40861894
29	FES	1.40635750
30	SYK	1.38688336
31	PINK1	1.36789657
32	CSF1R	1.31569372
33	TIE1	1.30483703
34	BTK	1.27023135
35	TNIK	1.24480560
36	MST4	1.21020859
37	PIK3CA	1.08910556
38	VRK2	1.07288450
39	MAP3K14	0.99704885
40	VRK1	0.99682617
41	MAPKAPK3	0.95084232
42	BMPR2	0.94272112
43	RPS6KA5	0.92964684
44	IRAK4	0.90277491
45	SRPK1	0.89791271
46	CDK19	0.89432488
47	MATK	0.87607787
48	PHKG1	0.87014188
49	PHKG2	0.87014188
50	LYN	0.85499754
51	FLT3	0.80695626
52	MAP3K7	0.79272144
53	BMPR1B	0.77200746
54	LCK	0.76879233
55	OXSR1	0.73967647
56	IRAK1	0.71962444
57	MAP2K6	0.71394236
58	JAK3	0.69263499
59	NLK	0.68399991
60	GRK6	0.67056556
61	PLK4	0.66822903
62	MAP3K4	0.66239188
63	MAP2K4	0.65265505
64	ATR	0.64079885
65	CSNK1G3	0.63861763
66	INSRR	0.60269772
67	PIK3CG	0.59642544
68	ABL2	0.59352209
69	ABL1	0.58040615
70	PDK2	0.56858808
71	NME1	0.55914968
72	MKNK1	0.55260126
73	EIF2AK2	0.55126633
74	NEK9	0.54706429
75	IRAK2	0.52779349
76	CSNK1G2	0.51788639
77	HCK	0.50604734
78	ADRBK1	0.48957054
79	MAPK13	0.48831616
80	IGF1R	0.48534024
81	CSNK1A1L	0.48307624
82	KDR	0.47463864
83	CDK3	0.46469277
84	CSNK1G1	0.44430663
85	PRKCQ	0.42911744
86	WNK4	0.42594744
87	MAPKAPK5	0.40908041
88	BLK	0.40672917
89	OBSCN	0.37714990
90	MAP3K5	0.35813363
91	RPS6KB2	0.35530344
92	CLK1	0.35442477
93	CSNK2A1	0.35193987
94	PLK3	0.32171940
95	CAMKK2	0.31838088
96	PRKCA	0.30398478
97	PRKCD	0.30385510
98	MAPK11	0.30044045
99	KSR2	0.29886636
100	RAF1	0.29353183

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.17538514
2	Allograft rejection_Homo sapiens_hsa05330	3.56461945
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.31401168
4	Graft-versus-host disease_Homo sapiens_hsa05332	3.27860331
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.09763389
6	Type I diabetes mellitus_Homo sapiens_hsa04940	2.86826009
7	Proteasome_Homo sapiens_hsa03050	2.79109118
8	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.62575973
9	Ribosome_Homo sapiens_hsa03010	2.22231686
10	Antigen processing and presentation_Homo sapiens_hsa04612	2.04086473
11	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.00621131
12	RNA polymerase_Homo sapiens_hsa03020	1.93023246
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.88091638
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.86678724
15	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.86631055
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.72634646
17	Leishmaniasis_Homo sapiens_hsa05140	1.70839185
18	DNA replication_Homo sapiens_hsa03030	1.67539403
19	Homologous recombination_Homo sapiens_hsa03440	1.67316037
20	Rheumatoid arthritis_Homo sapiens_hsa05323	1.66735078
21	Phototransduction_Homo sapiens_hsa04744	1.61828067
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.61318122
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.58768805
24	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.58038252
25	RNA degradation_Homo sapiens_hsa03018	1.50119006
26	Parkinsons disease_Homo sapiens_hsa05012	1.49956679
27	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.47954521
28	Peroxisome_Homo sapiens_hsa04146	1.47036532
29	Fatty acid elongation_Homo sapiens_hsa00062	1.42455234
30	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.40477127
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.38534071
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.35159036
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.32199478
34	Mismatch repair_Homo sapiens_hsa03430	1.28788248
35	Viral myocarditis_Homo sapiens_hsa05416	1.26672184
36	Propanoate metabolism_Homo sapiens_hsa00640	1.26598705
37	One carbon pool by folate_Homo sapiens_hsa00670	1.22073157
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.18218948
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.17603556
40	Nucleotide excision repair_Homo sapiens_hsa03420	1.17205910
41	Base excision repair_Homo sapiens_hsa03410	1.16517088
42	Primary immunodeficiency_Homo sapiens_hsa05340	1.16152133
43	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.14928851
44	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.09491085
45	Fanconi anemia pathway_Homo sapiens_hsa03460	1.02744601
46	Purine metabolism_Homo sapiens_hsa00230	1.02121978
47	Pertussis_Homo sapiens_hsa05133	1.01867239
48	Olfactory transduction_Homo sapiens_hsa04740	0.85696981
49	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.85598964
50	Linoleic acid metabolism_Homo sapiens_hsa00591	0.85205555
51	Spliceosome_Homo sapiens_hsa03040	0.84401000
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83980010
53	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.82820969
54	Fatty acid degradation_Homo sapiens_hsa00071	0.81883893
55	Legionellosis_Homo sapiens_hsa05134	0.76868900
56	Selenocompound metabolism_Homo sapiens_hsa00450	0.75048797
57	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.72727823
58	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.72265038
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68441411
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.68274518
61	Protein export_Homo sapiens_hsa03060	0.67701100
62	Butanoate metabolism_Homo sapiens_hsa00650	0.64693090
63	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.64541055
64	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.63374584
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63173944
66	RNA transport_Homo sapiens_hsa03013	0.62834068
67	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.60680090
68	Glutathione metabolism_Homo sapiens_hsa00480	0.60535646
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60361660
70	Alzheimers disease_Homo sapiens_hsa05010	0.60308528
71	Herpes simplex infection_Homo sapiens_hsa05168	0.59646836
72	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.57659929
73	Influenza A_Homo sapiens_hsa05164	0.57122871
74	Huntingtons disease_Homo sapiens_hsa05016	0.56650014
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.50392075
76	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.50346150
77	Retinol metabolism_Homo sapiens_hsa00830	0.46805485
78	Ether lipid metabolism_Homo sapiens_hsa00565	0.44538470
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43088145
80	Tuberculosis_Homo sapiens_hsa05152	0.42590672
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42373376
82	Toxoplasmosis_Homo sapiens_hsa05145	0.41775941
83	Salmonella infection_Homo sapiens_hsa05132	0.41391677
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40084194
85	Taste transduction_Homo sapiens_hsa04742	0.37887483
86	Metabolic pathways_Homo sapiens_hsa01100	0.34197156
87	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.32766329
88	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.31599460
89	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.30051381
90	Caffeine metabolism_Homo sapiens_hsa00232	0.28184087
91	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.27508017
92	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.27370726
93	Basal transcription factors_Homo sapiens_hsa03022	0.26622568
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.25725267
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.25529432
96	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.23111130
97	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.22651873
98	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.22263503
99	Histidine metabolism_Homo sapiens_hsa00340	0.21048673
100	Shigellosis_Homo sapiens_hsa05131	0.19578327

RPL18AP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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