ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.36236052
2	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	4.49962705
3	DNA deamination (GO:0045006)	4.27605046
4	cullin deneddylation (GO:0010388)	4.18955470
5	DNA double-strand break processing (GO:0000729)	4.11499913
6	platelet dense granule organization (GO:0060155)	4.01693347
7	aldehyde catabolic process (GO:0046185)	3.93777834
8	protein deneddylation (GO:0000338)	3.82723479
9	protein neddylation (GO:0045116)	3.79955351
10	proteasome assembly (GO:0043248)	3.77680960
11	respiratory chain complex IV assembly (GO:0008535)	3.70584060
12	neural tube formation (GO:0001841)	3.67949580
13	water-soluble vitamin biosynthetic process (GO:0042364)	3.54004725
14	fucose catabolic process (GO:0019317)	3.52955925
15	L-fucose metabolic process (GO:0042354)	3.52955925
16	L-fucose catabolic process (GO:0042355)	3.52955925
17	cytochrome complex assembly (GO:0017004)	3.40356828
18	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.39885043
19	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.28325581
20	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.26082958
21	behavioral response to nicotine (GO:0035095)	3.25320706
22	S-adenosylmethionine metabolic process (GO:0046500)	3.24870758
23	sequestering of actin monomers (GO:0042989)	3.24329942
24	replication fork processing (GO:0031297)	3.24248696
25	protein complex biogenesis (GO:0070271)	3.22564537
26	protein K6-linked ubiquitination (GO:0085020)	3.19706665
27	RNA destabilization (GO:0050779)	3.08772129
28	adenosine metabolic process (GO:0046085)	3.03614718
29	L-methionine salvage (GO:0071267)	3.03473630
30	L-methionine biosynthetic process (GO:0071265)	3.03473630
31	amino acid salvage (GO:0043102)	3.03473630
32	peptidyl-histidine modification (GO:0018202)	3.00602258
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.94384123
34	NADH dehydrogenase complex assembly (GO:0010257)	2.94384123
35	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.94384123
36	branched-chain amino acid catabolic process (GO:0009083)	2.93584210
37	CENP-A containing nucleosome assembly (GO:0034080)	2.91539080
38	mannosylation (GO:0097502)	2.91048392
39	cornea development in camera-type eye (GO:0061303)	2.86552416
40	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.85752896
41	regulation of mitotic spindle checkpoint (GO:1903504)	2.85752896
42	chromatin remodeling at centromere (GO:0031055)	2.85133492
43	DNA damage response, detection of DNA damage (GO:0042769)	2.84453538
44	pseudouridine synthesis (GO:0001522)	2.83700567
45	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.82161859
46	mitochondrial DNA replication (GO:0006264)	2.82138023
47	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.78220823
48	ATP synthesis coupled proton transport (GO:0015986)	2.78220823
49	behavioral response to ethanol (GO:0048149)	2.77305925
50	mitochondrial respiratory chain complex assembly (GO:0033108)	2.77188965
51	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.74214490
52	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.74214490
53	regulation of translation, ncRNA-mediated (GO:0045974)	2.74214490
54	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.70337813
55	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.70337813
56	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.68653815
57	histone mRNA catabolic process (GO:0071044)	2.67393082
58	pyrimidine nucleobase catabolic process (GO:0006208)	2.67306913
59	recombinational repair (GO:0000725)	2.66476693
60	double-strand break repair via homologous recombination (GO:0000724)	2.66243124
61	valine metabolic process (GO:0006573)	2.66002031
62	negative regulation of mast cell activation (GO:0033004)	2.64658437
63	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.63795396
64	DNA ligation (GO:0006266)	2.63732815
65	tRNA processing (GO:0008033)	2.61343850
66	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.60980476
67	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.60832194
68	histone exchange (GO:0043486)	2.60728581
69	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.60057799
70	regulation of regulatory T cell differentiation (GO:0045589)	2.59412991
71	rRNA catabolic process (GO:0016075)	2.56844467
72	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.56731371
73	DNA catabolic process, exonucleolytic (GO:0000738)	2.56513031
74	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.56043670
75	heparin biosynthetic process (GO:0030210)	2.54156680
76	heparin metabolic process (GO:0030202)	2.54156680
77	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.53099914
78	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.51085723
79	photoreceptor cell maintenance (GO:0045494)	2.50409376
80	positive regulation of mitochondrial fission (GO:0090141)	2.50063867
81	preassembly of GPI anchor in ER membrane (GO:0016254)	2.50028342
82	GPI anchor metabolic process (GO:0006505)	2.49908252
83	RNA phosphodiester bond hydrolysis (GO:0090501)	2.49458169
84	intraciliary transport (GO:0042073)	2.49318006
85	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.48497403
86	termination of RNA polymerase III transcription (GO:0006386)	2.48497403
87	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.48150789
88	presynaptic membrane assembly (GO:0097105)	2.47928570
89	protein polyglutamylation (GO:0018095)	2.47783072
90	centriole replication (GO:0007099)	2.46277233
91	tRNA modification (GO:0006400)	2.44429807
92	anterograde synaptic vesicle transport (GO:0048490)	2.44377072
93	mitotic metaphase plate congression (GO:0007080)	2.42333882
94	kinetochore assembly (GO:0051382)	2.41823611
95	histone mRNA metabolic process (GO:0008334)	2.41794418
96	DNA demethylation (GO:0080111)	2.41727765
97	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.40625743
98	metaphase plate congression (GO:0051310)	2.40498680
99	branched-chain amino acid metabolic process (GO:0009081)	2.39401175
100	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.39273083

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.01911155
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.62572456
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.14536798
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.06593391
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.02978517
6	IGF1R_20145208_ChIP-Seq_DFB_Human	3.01771872
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.92307651
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.81742374
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.78649445
10	FUS_26573619_Chip-Seq_HEK293_Human	2.56992470
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.56598390
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.56170178
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.53172019
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.52187145
15	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.44409188
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.42992671
17	VDR_22108803_ChIP-Seq_LS180_Human	2.40895779
18	EWS_26573619_Chip-Seq_HEK293_Human	2.35171134
19	VDR_23849224_ChIP-Seq_CD4+_Human	2.35081993
20	TAF15_26573619_Chip-Seq_HEK293_Human	2.26348874
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.06548955
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.90658376
23	P300_19829295_ChIP-Seq_ESCs_Human	1.90419589
24	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.83964401
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.83025534
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81526840
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.80435892
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.73211898
29	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.69010477
30	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.68301990
31	GBX2_23144817_ChIP-Seq_PC3_Human	1.62323403
32	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.59475304
33	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.57313734
34	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.56673604
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.54511585
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54393826
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.48780067
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.48167607
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47523170
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.46601470
41	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.45860436
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44963049
43	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.44044472
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.40643874
45	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.35458331
46	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.32199937
47	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.31176873
48	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.28977016
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25957592
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.25957592
51	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.24710792
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.24371478
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21442397
54	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.17152940
55	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16701596
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16343870
57	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.16343870
58	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.16255163
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.15835296
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.15638415
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14915942
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14915942
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13368610
64	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.11887578
65	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11697353
66	BCAT_22108803_ChIP-Seq_LS180_Human	1.11509004
67	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.11327745
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10829581
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10685113
70	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.10642734
71	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.10631799
72	AR_25329375_ChIP-Seq_VCAP_Human	1.10398753
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09978404
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09978404
75	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09423141
76	TCF4_23295773_ChIP-Seq_U87_Human	1.09034020
77	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.08122428
78	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.06713452
79	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.06674497
80	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.06378578
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05792772
82	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.03864727
83	AR_20517297_ChIP-Seq_VCAP_Human	1.03539593
84	GATA3_26560356_Chip-Seq_TH2_Human	1.02783815
85	SMAD4_21799915_ChIP-Seq_A2780_Human	1.00839693
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00224090
87	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.98940859
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.98876550
89	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98661577
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.95876062
91	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.95569265
92	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.94787884
93	STAT3_23295773_ChIP-Seq_U87_Human	0.94182383
94	NCOR_22424771_ChIP-Seq_293T_Human	0.93530454
95	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.92979773
96	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.92190117
97	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.91819086
98	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.90957562
99	P300_18555785_Chip-Seq_ESCs_Mouse	0.90130750
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.89471716

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	3.50889835
2	MP0002102_abnormal_ear_morphology	3.46779041
3	MP0002736_abnormal_nociception_after	2.75199205
4	MP0008058_abnormal_DNA_repair	2.60590813
5	MP0002138_abnormal_hepatobiliary_system	2.43085623
6	MP0006292_abnormal_olfactory_placode	2.42374288
7	MP0005084_abnormal_gallbladder_morpholo	2.35865158
8	MP0008877_abnormal_DNA_methylation	2.30226742
9	MP0002938_white_spotting	2.30045634
10	MP0001835_abnormal_antigen_presentation	2.19796131
11	MP0006072_abnormal_retinal_apoptosis	2.17553417
12	MP0001968_abnormal_touch/_nociception	2.16842031
13	MP0001529_abnormal_vocalization	2.14743233
14	MP0002234_abnormal_pharynx_morphology	2.08022240
15	MP0005646_abnormal_pituitary_gland	2.07245920
16	MP0003787_abnormal_imprinting	2.04790444
17	MP0005551_abnormal_eye_electrophysiolog	1.91779687
18	MP0010094_abnormal_chromosome_stability	1.89509216
19	MP0004147_increased_porphyrin_level	1.87455502
20	MP0005075_abnormal_melanosome_morpholog	1.82922335
21	MP0009697_abnormal_copulation	1.72892430
22	MP0003786_premature_aging	1.70169356
23	MP0005253_abnormal_eye_physiology	1.65461056
24	MP0002166_altered_tumor_susceptibility	1.65128790
25	MP0000569_abnormal_digit_pigmentation	1.62524385
26	MP0003567_abnormal_fetal_cardiomyocyte	1.62313705
27	MP0003172_abnormal_lysosome_physiology	1.57730776
28	MP0003880_abnormal_central_pattern	1.56880263
29	MP0003252_abnormal_bile_duct	1.56355184
30	MP0005671_abnormal_response_to	1.55003077
31	MP0002139_abnormal_hepatobiliary_system	1.54460640
32	MP0006035_abnormal_mitochondrial_morpho	1.46721460
33	MP0005367_renal/urinary_system_phenotyp	1.44248305
34	MP0000516_abnormal_urinary_system	1.44248305
35	MP0001984_abnormal_olfaction	1.43208214
36	MP0003718_maternal_effect	1.42571340
37	MP0005174_abnormal_tail_pigmentation	1.41286453
38	MP0008995_early_reproductive_senescence	1.40011200
39	MP0003693_abnormal_embryo_hatching	1.40009493
40	MP0001764_abnormal_homeostasis	1.39190136
41	MP0002638_abnormal_pupillary_reflex	1.36845152
42	MP0001486_abnormal_startle_reflex	1.34772426
43	MP0004142_abnormal_muscle_tone	1.31200075
44	MP0000015_abnormal_ear_pigmentation	1.29388895
45	MP0001324_abnormal_eye_pigmentation	1.29250289
46	MP0008789_abnormal_olfactory_epithelium	1.27744800
47	MP0002095_abnormal_skin_pigmentation	1.26612191
48	MP0009745_abnormal_behavioral_response	1.25603110
49	MP0008872_abnormal_physiological_respon	1.24961161
50	MP0003950_abnormal_plasma_membrane	1.20343797
51	MP0002006_tumorigenesis	1.19104079
52	MP0002282_abnormal_trachea_morphology	1.17917764
53	MP0000631_abnormal_neuroendocrine_gland	1.14151921
54	MP0006036_abnormal_mitochondrial_physio	1.09032104
55	MP0002751_abnormal_autonomic_nervous	1.07868291
56	MP0001293_anophthalmia	1.07304202
57	MP0001188_hyperpigmentation	1.03774897
58	MP0009046_muscle_twitch	1.02047169
59	MP0004215_abnormal_myocardial_fiber	1.00276347
60	MP0002928_abnormal_bile_duct	0.98620428
61	MP0002009_preneoplasia	0.97920789
62	MP0002272_abnormal_nervous_system	0.97252153
63	MP0001485_abnormal_pinna_reflex	0.97087177
64	MP0005410_abnormal_fertilization	0.95998436
65	MP0008875_abnormal_xenobiotic_pharmacok	0.94578067
66	MP0002837_dystrophic_cardiac_calcinosis	0.94356012
67	MP0003186_abnormal_redox_activity	0.94053043
68	MP0004742_abnormal_vestibular_system	0.93437813
69	MP0004885_abnormal_endolymph	0.92260906
70	MP0004145_abnormal_muscle_electrophysio	0.91477273
71	MP0001119_abnormal_female_reproductive	0.90490048
72	MP0001905_abnormal_dopamine_level	0.89843002
73	MP0003137_abnormal_impulse_conducting	0.89345967
74	MP0005195_abnormal_posterior_eye	0.87558660
75	MP0000647_abnormal_sebaceous_gland	0.86156755
76	MP0002090_abnormal_vision	0.80556452
77	MP0004924_abnormal_behavior	0.79832650
78	MP0005386_behavior/neurological_phenoty	0.79832650
79	MP0003698_abnormal_male_reproductive	0.78458059
80	MP0003111_abnormal_nucleus_morphology	0.76225004
81	MP0001177_atelectasis	0.74580983
82	MP0001501_abnormal_sleep_pattern	0.73625809
83	MP0002572_abnormal_emotion/affect_behav	0.73113373
84	MP0001929_abnormal_gametogenesis	0.72221849
85	MP0009765_abnormal_xenobiotic_induced	0.71723230
86	MP0001661_extended_life_span	0.71225266
87	MP0001919_abnormal_reproductive_system	0.71168727
88	MP0002067_abnormal_sensory_capabilities	0.70973224
89	MP0005499_abnormal_olfactory_system	0.69901666
90	MP0005394_taste/olfaction_phenotype	0.69901666
91	MP0000538_abnormal_urinary_bladder	0.68495722
92	MP0004957_abnormal_blastocyst_morpholog	0.68022390
93	MP0000653_abnormal_sex_gland	0.67885904
94	MP0003077_abnormal_cell_cycle	0.67820213
95	MP0005389_reproductive_system_phenotype	0.67516865
96	MP0005360_urolithiasis	0.65328634
97	MP0002148_abnormal_hypersensitivity_rea	0.65047082
98	MP0002752_abnormal_somatic_nervous	0.65021242
99	MP0009764_decreased_sensitivity_to	0.64923503
100	MP0001873_stomach_inflammation	0.63078719

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the renal cortex (HP:0011035)	3.79733898
2	Renal cortical cysts (HP:0000803)	3.47623122
3	Pancreatic cysts (HP:0001737)	3.46418196
4	Abnormality of B cell number (HP:0010975)	3.36502329
5	Molar tooth sign on MRI (HP:0002419)	3.24451609
6	Abnormality of midbrain morphology (HP:0002418)	3.24451609
7	B lymphocytopenia (HP:0010976)	3.19640612
8	Progressive inability to walk (HP:0002505)	3.18829197
9	Nephronophthisis (HP:0000090)	3.16320324
10	Abnormality of the renal medulla (HP:0100957)	3.16025433
11	Panhypogammaglobulinemia (HP:0003139)	3.12225318
12	Pancreatic fibrosis (HP:0100732)	3.09701696
13	Thyroiditis (HP:0100646)	2.93103469
14	Severe combined immunodeficiency (HP:0004430)	2.83862203
15	Hepatocellular necrosis (HP:0001404)	2.75363252
16	Hepatic necrosis (HP:0002605)	2.67804728
17	Progressive macrocephaly (HP:0004481)	2.63381168
18	Increased corneal curvature (HP:0100692)	2.63152735
19	Keratoconus (HP:0000563)	2.63152735
20	Mitochondrial inheritance (HP:0001427)	2.57685217
21	Abolished electroretinogram (ERG) (HP:0000550)	2.57640063
22	Acute necrotizing encephalopathy (HP:0006965)	2.57212575
23	True hermaphroditism (HP:0010459)	2.57064315
24	Short tibia (HP:0005736)	2.56838190
25	Increased CSF lactate (HP:0002490)	2.54695026
26	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.53427579
27	Volvulus (HP:0002580)	2.52475596
28	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.48931039
29	Tubulointerstitial fibrosis (HP:0005576)	2.46696120
30	Hypoplastic pelvis (HP:0008839)	2.43426770
31	Increased hepatocellular lipid droplets (HP:0006565)	2.41718540
32	Bile duct proliferation (HP:0001408)	2.38820126
33	Abnormal biliary tract physiology (HP:0012439)	2.38820126
34	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.37610986
35	Attenuation of retinal blood vessels (HP:0007843)	2.35976074
36	Combined immunodeficiency (HP:0005387)	2.33575963
37	Hypoproteinemia (HP:0003075)	2.32803378
38	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.31723202
39	Stomach cancer (HP:0012126)	2.31044431
40	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.29886374
41	Congenital, generalized hypertrichosis (HP:0004540)	2.29138380
42	Fibular aplasia (HP:0002990)	2.28866514
43	Hyperventilation (HP:0002883)	2.28250797
44	Acute encephalopathy (HP:0006846)	2.27868164
45	Abnormal mitochondria in muscle tissue (HP:0008316)	2.26379417
46	Lipid accumulation in hepatocytes (HP:0006561)	2.26185227
47	Hypothermia (HP:0002045)	2.26183472
48	Hyperglycinemia (HP:0002154)	2.22103813
49	Tubular atrophy (HP:0000092)	2.18988916
50	Optic disc pallor (HP:0000543)	2.17715758
51	Type 2 muscle fiber atrophy (HP:0003554)	2.12400914
52	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.11312312
53	Short 1st metacarpal (HP:0010034)	2.11312312
54	3-Methylglutaconic aciduria (HP:0003535)	2.11156143
55	Congenital stationary night blindness (HP:0007642)	2.10121870
56	Hyperglycinuria (HP:0003108)	2.09945621
57	Methylmalonic acidemia (HP:0002912)	2.08912615
58	Medial flaring of the eyebrow (HP:0010747)	2.07618557
59	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.04101224
60	Abnormality of serine family amino acid metabolism (HP:0010894)	2.03409745
61	Abnormality of glycine metabolism (HP:0010895)	2.03409745
62	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.02648245
63	Inability to walk (HP:0002540)	2.01837741
64	Aplasia/hypoplasia of the uterus (HP:0008684)	2.00713510
65	Increased serum lactate (HP:0002151)	2.00575001
66	Abnormality of urine glucose concentration (HP:0011016)	1.94849529
67	Glycosuria (HP:0003076)	1.94849529
68	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.92958494
69	Abnormality of chromosome stability (HP:0003220)	1.90874333
70	Abnormal drinking behavior (HP:0030082)	1.90034794
71	Polydipsia (HP:0001959)	1.90034794
72	Type I transferrin isoform profile (HP:0003642)	1.89789684
73	Colon cancer (HP:0003003)	1.89478720
74	Postaxial foot polydactyly (HP:0001830)	1.86597073
75	Abnormality of the 1st metacarpal (HP:0010009)	1.86563026
76	Oligodactyly (hands) (HP:0001180)	1.86411151
77	Tubulointerstitial abnormality (HP:0001969)	1.85574005
78	Postaxial hand polydactyly (HP:0001162)	1.85484444
79	Cystic liver disease (HP:0006706)	1.85293389
80	Hypoplasia of the uterus (HP:0000013)	1.84961635
81	Pendular nystagmus (HP:0012043)	1.82966915
82	Abnormality of the labia minora (HP:0012880)	1.82723096
83	Meckel diverticulum (HP:0002245)	1.82008485
84	Adactyly (HP:0009776)	1.80882389
85	Abnormality of the ileum (HP:0001549)	1.80556408
86	Polyuria (HP:0000103)	1.79283555
87	Renal Fanconi syndrome (HP:0001994)	1.78672653
88	Abnormality of the prostate (HP:0008775)	1.76763511
89	IgG deficiency (HP:0004315)	1.76080597
90	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.75363623
91	Abnormal protein N-linked glycosylation (HP:0012347)	1.75363623
92	Abnormal protein glycosylation (HP:0012346)	1.75363623
93	Abnormal glycosylation (HP:0012345)	1.75363623
94	IgM deficiency (HP:0002850)	1.75166904
95	Chronic hepatic failure (HP:0100626)	1.73870408
96	Dyschromatopsia (HP:0007641)	1.73766150
97	Methylmalonic aciduria (HP:0012120)	1.72697755
98	Aplastic anemia (HP:0001915)	1.69104023
99	Congenital hepatic fibrosis (HP:0002612)	1.68244869
100	Lactic acidosis (HP:0003128)	1.67773765

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.17891799
2	FRK	3.39106367
3	EIF2AK3	3.13041974
4	NUAK1	2.87386895
5	TNIK	2.80869827
6	BMPR1B	2.44446104
7	TAOK3	2.26101125
8	TXK	2.11827103
9	TRIM28	2.11281550
10	ERBB3	2.04804535
11	MAPK13	1.92182137
12	PINK1	1.83052697
13	NTRK3	1.82742204
14	GRK7	1.81451514
15	MAP3K4	1.74463601
16	WEE1	1.73175779
17	EIF2AK2	1.68104972
18	NEK1	1.66304076
19	TLK1	1.64702828
20	EIF2AK1	1.59940390
21	PLK3	1.59633559
22	GRK1	1.56694766
23	ZAK	1.55978535
24	DYRK2	1.53747239
25	BUB1	1.50357330
26	PLK4	1.46573647
27	TGFBR1	1.45137174
28	BCKDK	1.39829678
29	VRK2	1.32476682
30	ACVR1B	1.28031233
31	MUSK	1.26395253
32	SIK3	1.24709325
33	TAF1	1.23860569
34	PLK2	1.16951957
35	SRPK1	1.13400747
36	MKNK1	1.12322714
37	TEC	1.11429581
38	MAP3K14	1.10128492
39	ADRBK2	1.09217203
40	WNK4	1.08698600
41	RPS6KA4	1.03048487
42	WNK3	1.02050479
43	MARK1	0.98721741
44	KIT	0.98656497
45	VRK1	0.98570803
46	CCNB1	0.95048632
47	AKT3	0.93570644
48	MAPKAPK3	0.93014950
49	TSSK6	0.90345966
50	OXSR1	0.90211468
51	STK39	0.89761307
52	TIE1	0.84762572
53	FGFR2	0.81425385
54	BCR	0.79319516
55	TTK	0.79224830
56	MKNK2	0.76466864
57	CSNK1G2	0.75469002
58	MINK1	0.74306869
59	BRSK2	0.73797056
60	BMPR2	0.73113865
61	CDK8	0.72894263
62	INSRR	0.72099491
63	FLT3	0.71384336
64	STK16	0.68881543
65	IKBKE	0.67894829
66	CSNK1G1	0.58376129
67	MAP2K7	0.57141136
68	CDC7	0.56029759
69	ADRBK1	0.54827811
70	MAP4K1	0.54400946
71	PLK1	0.54170037
72	CSNK1G3	0.53338568
73	EPHA3	0.50657622
74	PAK3	0.49127812
75	ATR	0.48699434
76	ITK	0.48636914
77	PASK	0.48357324
78	ATM	0.46602887
79	MARK3	0.45749106
80	SIK2	0.45508971
81	CASK	0.44263636
82	CSNK1A1L	0.44128147
83	PRKD3	0.43990814
84	IGF1R	0.40613470
85	AURKB	0.40527272
86	RPS6KA5	0.40291691
87	IKBKB	0.40086555
88	NEK2	0.39968585
89	ABL1	0.39776887
90	BTK	0.38600670
91	LYN	0.38493726
92	PRKCQ	0.37767880
93	MST4	0.37707519
94	CDK3	0.36929050
95	PRKCE	0.34017499
96	CHEK2	0.33952022
97	FER	0.32755817
98	MAP2K6	0.32693012
99	GRK5	0.31482760
100	SYK	0.30589600

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.49667011
2	Proteasome_Homo sapiens_hsa03050	3.09602611
3	Protein export_Homo sapiens_hsa03060	2.58643695
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.57072010
5	Allograft rejection_Homo sapiens_hsa05330	2.56738280
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.51571150
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.40733939
8	Basal transcription factors_Homo sapiens_hsa03022	2.39915096
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.37326653
10	Propanoate metabolism_Homo sapiens_hsa00640	2.36408588
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.33106899
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.13478516
13	RNA degradation_Homo sapiens_hsa03018	2.11151555
14	Type I diabetes mellitus_Homo sapiens_hsa04940	2.09004117
15	Fanconi anemia pathway_Homo sapiens_hsa03460	2.07417289
16	Homologous recombination_Homo sapiens_hsa03440	2.06886892
17	Phototransduction_Homo sapiens_hsa04744	2.01802705
18	RNA polymerase_Homo sapiens_hsa03020	1.95059163
19	Oxidative phosphorylation_Homo sapiens_hsa00190	1.93850607
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.86471759
21	Parkinsons disease_Homo sapiens_hsa05012	1.73684985
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.69148523
23	Butanoate metabolism_Homo sapiens_hsa00650	1.68404392
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.62618278
25	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.62607938
26	One carbon pool by folate_Homo sapiens_hsa00670	1.53610014
27	Primary immunodeficiency_Homo sapiens_hsa05340	1.49462953
28	Antigen processing and presentation_Homo sapiens_hsa04612	1.33879127
29	Base excision repair_Homo sapiens_hsa03410	1.31835686
30	RNA transport_Homo sapiens_hsa03013	1.30181467
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.26171688
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.25651248
33	Mismatch repair_Homo sapiens_hsa03430	1.22474357
34	Steroid biosynthesis_Homo sapiens_hsa00100	1.19831817
35	Nucleotide excision repair_Homo sapiens_hsa03420	1.17616391
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.13457218
37	Huntingtons disease_Homo sapiens_hsa05016	1.13448108
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.11818999
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.11390539
40	Spliceosome_Homo sapiens_hsa03040	1.04518483
41	Fatty acid elongation_Homo sapiens_hsa00062	1.01856134
42	Purine metabolism_Homo sapiens_hsa00230	1.01408640
43	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00944336
44	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00825805
45	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.96743609
46	Peroxisome_Homo sapiens_hsa04146	0.94429391
47	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.91692203
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.91670377
49	Taste transduction_Homo sapiens_hsa04742	0.88138822
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87776693
51	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.87233411
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.86557140
53	Rheumatoid arthritis_Homo sapiens_hsa05323	0.86145831
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.85646161
55	Alzheimers disease_Homo sapiens_hsa05010	0.85262788
56	Nicotine addiction_Homo sapiens_hsa05033	0.84301209
57	Viral myocarditis_Homo sapiens_hsa05416	0.84245036
58	Ribosome_Homo sapiens_hsa03010	0.78458078
59	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.78260233
60	Regulation of autophagy_Homo sapiens_hsa04140	0.77180314
61	Olfactory transduction_Homo sapiens_hsa04740	0.76444315
62	Selenocompound metabolism_Homo sapiens_hsa00450	0.74387438
63	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.72863348
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69053749
65	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.68837247
66	DNA replication_Homo sapiens_hsa03030	0.62545351
67	Fatty acid metabolism_Homo sapiens_hsa01212	0.62130800
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.61204574
69	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.59387079
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.58483768
71	Metabolic pathways_Homo sapiens_hsa01100	0.56461190
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56023179
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.54875638
74	Glutathione metabolism_Homo sapiens_hsa00480	0.53458398
75	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.53325184
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53124584
77	Fatty acid degradation_Homo sapiens_hsa00071	0.52599963
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52318564
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51766233
80	Herpes simplex infection_Homo sapiens_hsa05168	0.51676142
81	Caffeine metabolism_Homo sapiens_hsa00232	0.50264016
82	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.48754049
83	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.48731143
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48421739
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47793221
86	Fat digestion and absorption_Homo sapiens_hsa04975	0.47759896
87	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43515867
88	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.42773292
89	Cell cycle_Homo sapiens_hsa04110	0.40804494
90	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.40188445
91	Pyruvate metabolism_Homo sapiens_hsa00620	0.38836651
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38116681
93	Leishmaniasis_Homo sapiens_hsa05140	0.36794439
94	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.36747418
95	Cardiac muscle contraction_Homo sapiens_hsa04260	0.36466215
96	Serotonergic synapse_Homo sapiens_hsa04726	0.33581274
97	Circadian entrainment_Homo sapiens_hsa04713	0.33526060
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31811840
99	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.29065434
100	Retinol metabolism_Homo sapiens_hsa00830	0.28368498

RPL18AP7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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