RPL18AP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.36236052
2RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.49962705
3DNA deamination (GO:0045006)4.27605046
4cullin deneddylation (GO:0010388)4.18955470
5DNA double-strand break processing (GO:0000729)4.11499913
6platelet dense granule organization (GO:0060155)4.01693347
7aldehyde catabolic process (GO:0046185)3.93777834
8protein deneddylation (GO:0000338)3.82723479
9protein neddylation (GO:0045116)3.79955351
10proteasome assembly (GO:0043248)3.77680960
11respiratory chain complex IV assembly (GO:0008535)3.70584060
12neural tube formation (GO:0001841)3.67949580
13water-soluble vitamin biosynthetic process (GO:0042364)3.54004725
14fucose catabolic process (GO:0019317)3.52955925
15L-fucose metabolic process (GO:0042354)3.52955925
16L-fucose catabolic process (GO:0042355)3.52955925
17cytochrome complex assembly (GO:0017004)3.40356828
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.39885043
19nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28325581
20exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.26082958
21behavioral response to nicotine (GO:0035095)3.25320706
22S-adenosylmethionine metabolic process (GO:0046500)3.24870758
23sequestering of actin monomers (GO:0042989)3.24329942
24replication fork processing (GO:0031297)3.24248696
25protein complex biogenesis (GO:0070271)3.22564537
26protein K6-linked ubiquitination (GO:0085020)3.19706665
27RNA destabilization (GO:0050779)3.08772129
28adenosine metabolic process (GO:0046085)3.03614718
29L-methionine salvage (GO:0071267)3.03473630
30L-methionine biosynthetic process (GO:0071265)3.03473630
31amino acid salvage (GO:0043102)3.03473630
32peptidyl-histidine modification (GO:0018202)3.00602258
33NADH dehydrogenase complex assembly (GO:0010257)2.94384123
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94384123
35mitochondrial respiratory chain complex I assembly (GO:0032981)2.94384123
36branched-chain amino acid catabolic process (GO:0009083)2.93584210
37CENP-A containing nucleosome assembly (GO:0034080)2.91539080
38mannosylation (GO:0097502)2.91048392
39cornea development in camera-type eye (GO:0061303)2.86552416
40regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.85752896
41regulation of mitotic spindle checkpoint (GO:1903504)2.85752896
42chromatin remodeling at centromere (GO:0031055)2.85133492
43DNA damage response, detection of DNA damage (GO:0042769)2.84453538
44pseudouridine synthesis (GO:0001522)2.83700567
45negative regulation of DNA-dependent DNA replication (GO:2000104)2.82161859
46mitochondrial DNA replication (GO:0006264)2.82138023
47energy coupled proton transport, down electrochemical gradient (GO:0015985)2.78220823
48ATP synthesis coupled proton transport (GO:0015986)2.78220823
49behavioral response to ethanol (GO:0048149)2.77305925
50mitochondrial respiratory chain complex assembly (GO:0033108)2.77188965
51negative regulation of translation, ncRNA-mediated (GO:0040033)2.74214490
52regulation of translation, ncRNA-mediated (GO:0045974)2.74214490
53negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.74214490
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.70337813
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.70337813
56detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.68653815
57histone mRNA catabolic process (GO:0071044)2.67393082
58pyrimidine nucleobase catabolic process (GO:0006208)2.67306913
59recombinational repair (GO:0000725)2.66476693
60double-strand break repair via homologous recombination (GO:0000724)2.66243124
61valine metabolic process (GO:0006573)2.66002031
62negative regulation of mast cell activation (GO:0033004)2.64658437
63regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.63795396
64DNA ligation (GO:0006266)2.63732815
65tRNA processing (GO:0008033)2.61343850
66mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.60980476
67regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.60832194
68histone exchange (GO:0043486)2.60728581
69positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.60057799
70regulation of regulatory T cell differentiation (GO:0045589)2.59412991
71rRNA catabolic process (GO:0016075)2.56844467
72epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.56731371
73DNA catabolic process, exonucleolytic (GO:0000738)2.56513031
74positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.56043670
75heparin biosynthetic process (GO:0030210)2.54156680
76heparin metabolic process (GO:0030202)2.54156680
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.53099914
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.51085723
79photoreceptor cell maintenance (GO:0045494)2.50409376
80positive regulation of mitochondrial fission (GO:0090141)2.50063867
81preassembly of GPI anchor in ER membrane (GO:0016254)2.50028342
82GPI anchor metabolic process (GO:0006505)2.49908252
83RNA phosphodiester bond hydrolysis (GO:0090501)2.49458169
84intraciliary transport (GO:0042073)2.49318006
85transcription elongation from RNA polymerase III promoter (GO:0006385)2.48497403
86termination of RNA polymerase III transcription (GO:0006386)2.48497403
87maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.48150789
88presynaptic membrane assembly (GO:0097105)2.47928570
89protein polyglutamylation (GO:0018095)2.47783072
90centriole replication (GO:0007099)2.46277233
91tRNA modification (GO:0006400)2.44429807
92anterograde synaptic vesicle transport (GO:0048490)2.44377072
93mitotic metaphase plate congression (GO:0007080)2.42333882
94kinetochore assembly (GO:0051382)2.41823611
95histone mRNA metabolic process (GO:0008334)2.41794418
96DNA demethylation (GO:0080111)2.41727765
97DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.40625743
98metaphase plate congression (GO:0051310)2.40498680
99branched-chain amino acid metabolic process (GO:0009081)2.39401175
100negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.39273083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.01911155
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.62572456
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.14536798
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.06593391
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.02978517
6IGF1R_20145208_ChIP-Seq_DFB_Human3.01771872
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.92307651
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.81742374
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78649445
10FUS_26573619_Chip-Seq_HEK293_Human2.56992470
11ELK1_19687146_ChIP-ChIP_HELA_Human2.56598390
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.56170178
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.53172019
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52187145
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44409188
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42992671
17VDR_22108803_ChIP-Seq_LS180_Human2.40895779
18EWS_26573619_Chip-Seq_HEK293_Human2.35171134
19VDR_23849224_ChIP-Seq_CD4+_Human2.35081993
20TAF15_26573619_Chip-Seq_HEK293_Human2.26348874
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06548955
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90658376
23P300_19829295_ChIP-Seq_ESCs_Human1.90419589
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83964401
25MYC_18940864_ChIP-ChIP_HL60_Human1.83025534
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81526840
27FOXP3_21729870_ChIP-Seq_TREG_Human1.80435892
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73211898
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69010477
30GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.68301990
31GBX2_23144817_ChIP-Seq_PC3_Human1.62323403
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.59475304
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57313734
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56673604
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.54511585
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54393826
37ER_23166858_ChIP-Seq_MCF-7_Human1.48780067
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48167607
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47523170
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46601470
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45860436
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44963049
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44044472
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40643874
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35458331
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.32199937
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31176873
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28977016
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25957592
50CBP_20019798_ChIP-Seq_JUKART_Human1.25957592
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24710792
52IRF1_19129219_ChIP-ChIP_H3396_Human1.24371478
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21442397
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17152940
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.16701596
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16343870
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16343870
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16255163
59TCF4_22108803_ChIP-Seq_LS180_Human1.15835296
60TP53_22573176_ChIP-Seq_HFKS_Human1.15638415
61NANOG_19829295_ChIP-Seq_ESCs_Human1.14915942
62SOX2_19829295_ChIP-Seq_ESCs_Human1.14915942
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13368610
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11887578
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11697353
66BCAT_22108803_ChIP-Seq_LS180_Human1.11509004
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11327745
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.10829581
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10685113
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.10642734
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10631799
72AR_25329375_ChIP-Seq_VCAP_Human1.10398753
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.09978404
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09978404
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09423141
76TCF4_23295773_ChIP-Seq_U87_Human1.09034020
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08122428
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.06713452
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06674497
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06378578
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05792772
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03864727
83AR_20517297_ChIP-Seq_VCAP_Human1.03539593
84GATA3_26560356_Chip-Seq_TH2_Human1.02783815
85SMAD4_21799915_ChIP-Seq_A2780_Human1.00839693
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.00224090
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98940859
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.98876550
89TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98661577
90NANOG_18555785_Chip-Seq_ESCs_Mouse0.95876062
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95569265
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94787884
93STAT3_23295773_ChIP-Seq_U87_Human0.94182383
94NCOR_22424771_ChIP-Seq_293T_Human0.93530454
95TAL1_26923725_Chip-Seq_HPCs_Mouse0.92979773
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92190117
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91819086
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90957562
99P300_18555785_Chip-Seq_ESCs_Mouse0.90130750
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89471716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation3.50889835
2MP0002102_abnormal_ear_morphology3.46779041
3MP0002736_abnormal_nociception_after2.75199205
4MP0008058_abnormal_DNA_repair2.60590813
5MP0002138_abnormal_hepatobiliary_system2.43085623
6MP0006292_abnormal_olfactory_placode2.42374288
7MP0005084_abnormal_gallbladder_morpholo2.35865158
8MP0008877_abnormal_DNA_methylation2.30226742
9MP0002938_white_spotting2.30045634
10MP0001835_abnormal_antigen_presentation2.19796131
11MP0006072_abnormal_retinal_apoptosis2.17553417
12MP0001968_abnormal_touch/_nociception2.16842031
13MP0001529_abnormal_vocalization2.14743233
14MP0002234_abnormal_pharynx_morphology2.08022240
15MP0005646_abnormal_pituitary_gland2.07245920
16MP0003787_abnormal_imprinting2.04790444
17MP0005551_abnormal_eye_electrophysiolog1.91779687
18MP0010094_abnormal_chromosome_stability1.89509216
19MP0004147_increased_porphyrin_level1.87455502
20MP0005075_abnormal_melanosome_morpholog1.82922335
21MP0009697_abnormal_copulation1.72892430
22MP0003786_premature_aging1.70169356
23MP0005253_abnormal_eye_physiology1.65461056
24MP0002166_altered_tumor_susceptibility1.65128790
25MP0000569_abnormal_digit_pigmentation1.62524385
26MP0003567_abnormal_fetal_cardiomyocyte1.62313705
27MP0003172_abnormal_lysosome_physiology1.57730776
28MP0003880_abnormal_central_pattern1.56880263
29MP0003252_abnormal_bile_duct1.56355184
30MP0005671_abnormal_response_to1.55003077
31MP0002139_abnormal_hepatobiliary_system1.54460640
32MP0006035_abnormal_mitochondrial_morpho1.46721460
33MP0000516_abnormal_urinary_system1.44248305
34MP0005367_renal/urinary_system_phenotyp1.44248305
35MP0001984_abnormal_olfaction1.43208214
36MP0003718_maternal_effect1.42571340
37MP0005174_abnormal_tail_pigmentation1.41286453
38MP0008995_early_reproductive_senescence1.40011200
39MP0003693_abnormal_embryo_hatching1.40009493
40MP0001764_abnormal_homeostasis1.39190136
41MP0002638_abnormal_pupillary_reflex1.36845152
42MP0001486_abnormal_startle_reflex1.34772426
43MP0004142_abnormal_muscle_tone1.31200075
44MP0000015_abnormal_ear_pigmentation1.29388895
45MP0001324_abnormal_eye_pigmentation1.29250289
46MP0008789_abnormal_olfactory_epithelium1.27744800
47MP0002095_abnormal_skin_pigmentation1.26612191
48MP0009745_abnormal_behavioral_response1.25603110
49MP0008872_abnormal_physiological_respon1.24961161
50MP0003950_abnormal_plasma_membrane1.20343797
51MP0002006_tumorigenesis1.19104079
52MP0002282_abnormal_trachea_morphology1.17917764
53MP0000631_abnormal_neuroendocrine_gland1.14151921
54MP0006036_abnormal_mitochondrial_physio1.09032104
55MP0002751_abnormal_autonomic_nervous1.07868291
56MP0001293_anophthalmia1.07304202
57MP0001188_hyperpigmentation1.03774897
58MP0009046_muscle_twitch1.02047169
59MP0004215_abnormal_myocardial_fiber1.00276347
60MP0002928_abnormal_bile_duct0.98620428
61MP0002009_preneoplasia0.97920789
62MP0002272_abnormal_nervous_system0.97252153
63MP0001485_abnormal_pinna_reflex0.97087177
64MP0005410_abnormal_fertilization0.95998436
65MP0008875_abnormal_xenobiotic_pharmacok0.94578067
66MP0002837_dystrophic_cardiac_calcinosis0.94356012
67MP0003186_abnormal_redox_activity0.94053043
68MP0004742_abnormal_vestibular_system0.93437813
69MP0004885_abnormal_endolymph0.92260906
70MP0004145_abnormal_muscle_electrophysio0.91477273
71MP0001119_abnormal_female_reproductive0.90490048
72MP0001905_abnormal_dopamine_level0.89843002
73MP0003137_abnormal_impulse_conducting0.89345967
74MP0005195_abnormal_posterior_eye0.87558660
75MP0000647_abnormal_sebaceous_gland0.86156755
76MP0002090_abnormal_vision0.80556452
77MP0005386_behavior/neurological_phenoty0.79832650
78MP0004924_abnormal_behavior0.79832650
79MP0003698_abnormal_male_reproductive0.78458059
80MP0003111_abnormal_nucleus_morphology0.76225004
81MP0001177_atelectasis0.74580983
82MP0001501_abnormal_sleep_pattern0.73625809
83MP0002572_abnormal_emotion/affect_behav0.73113373
84MP0001929_abnormal_gametogenesis0.72221849
85MP0009765_abnormal_xenobiotic_induced0.71723230
86MP0001661_extended_life_span0.71225266
87MP0001919_abnormal_reproductive_system0.71168727
88MP0002067_abnormal_sensory_capabilities0.70973224
89MP0005394_taste/olfaction_phenotype0.69901666
90MP0005499_abnormal_olfactory_system0.69901666
91MP0000538_abnormal_urinary_bladder0.68495722
92MP0004957_abnormal_blastocyst_morpholog0.68022390
93MP0000653_abnormal_sex_gland0.67885904
94MP0003077_abnormal_cell_cycle0.67820213
95MP0005389_reproductive_system_phenotype0.67516865
96MP0005360_urolithiasis0.65328634
97MP0002148_abnormal_hypersensitivity_rea0.65047082
98MP0002752_abnormal_somatic_nervous0.65021242
99MP0009764_decreased_sensitivity_to0.64923503
100MP0001873_stomach_inflammation0.63078719

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the renal cortex (HP:0011035)3.79733898
2Renal cortical cysts (HP:0000803)3.47623122
3Pancreatic cysts (HP:0001737)3.46418196
4Abnormality of B cell number (HP:0010975)3.36502329
5Molar tooth sign on MRI (HP:0002419)3.24451609
6Abnormality of midbrain morphology (HP:0002418)3.24451609
7B lymphocytopenia (HP:0010976)3.19640612
8Progressive inability to walk (HP:0002505)3.18829197
9Nephronophthisis (HP:0000090)3.16320324
10Abnormality of the renal medulla (HP:0100957)3.16025433
11Panhypogammaglobulinemia (HP:0003139)3.12225318
12Pancreatic fibrosis (HP:0100732)3.09701696
13Thyroiditis (HP:0100646)2.93103469
14Severe combined immunodeficiency (HP:0004430)2.83862203
15Hepatocellular necrosis (HP:0001404)2.75363252
16Hepatic necrosis (HP:0002605)2.67804728
17Progressive macrocephaly (HP:0004481)2.63381168
18Increased corneal curvature (HP:0100692)2.63152735
19Keratoconus (HP:0000563)2.63152735
20Mitochondrial inheritance (HP:0001427)2.57685217
21Abolished electroretinogram (ERG) (HP:0000550)2.57640063
22Acute necrotizing encephalopathy (HP:0006965)2.57212575
23True hermaphroditism (HP:0010459)2.57064315
24Short tibia (HP:0005736)2.56838190
25Increased CSF lactate (HP:0002490)2.54695026
26Aplasia/Hypoplasia of the tibia (HP:0005772)2.53427579
27Volvulus (HP:0002580)2.52475596
28Abnormality of the proximal phalanges of the hand (HP:0009834)2.48931039
29Tubulointerstitial fibrosis (HP:0005576)2.46696120
30Hypoplastic pelvis (HP:0008839)2.43426770
31Increased hepatocellular lipid droplets (HP:0006565)2.41718540
32Bile duct proliferation (HP:0001408)2.38820126
33Abnormal biliary tract physiology (HP:0012439)2.38820126
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.37610986
35Attenuation of retinal blood vessels (HP:0007843)2.35976074
36Combined immunodeficiency (HP:0005387)2.33575963
37Hypoproteinemia (HP:0003075)2.32803378
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31723202
39Stomach cancer (HP:0012126)2.31044431
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.29886374
41Congenital, generalized hypertrichosis (HP:0004540)2.29138380
42Fibular aplasia (HP:0002990)2.28866514
43Hyperventilation (HP:0002883)2.28250797
44Acute encephalopathy (HP:0006846)2.27868164
45Abnormal mitochondria in muscle tissue (HP:0008316)2.26379417
46Lipid accumulation in hepatocytes (HP:0006561)2.26185227
47Hypothermia (HP:0002045)2.26183472
48Hyperglycinemia (HP:0002154)2.22103813
49Tubular atrophy (HP:0000092)2.18988916
50Optic disc pallor (HP:0000543)2.17715758
51Type 2 muscle fiber atrophy (HP:0003554)2.12400914
52Short 1st metacarpal (HP:0010034)2.11312312
53Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.11312312
543-Methylglutaconic aciduria (HP:0003535)2.11156143
55Congenital stationary night blindness (HP:0007642)2.10121870
56Hyperglycinuria (HP:0003108)2.09945621
57Methylmalonic acidemia (HP:0002912)2.08912615
58Medial flaring of the eyebrow (HP:0010747)2.07618557
59Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04101224
60Abnormality of serine family amino acid metabolism (HP:0010894)2.03409745
61Abnormality of glycine metabolism (HP:0010895)2.03409745
62Abnormality of the phalanges of the 2nd finger (HP:0009541)2.02648245
63Inability to walk (HP:0002540)2.01837741
64Aplasia/hypoplasia of the uterus (HP:0008684)2.00713510
65Increased serum lactate (HP:0002151)2.00575001
66Glycosuria (HP:0003076)1.94849529
67Abnormality of urine glucose concentration (HP:0011016)1.94849529
68Aplasia/Hypoplasia of the uvula (HP:0010293)1.92958494
69Abnormality of chromosome stability (HP:0003220)1.90874333
70Abnormal drinking behavior (HP:0030082)1.90034794
71Polydipsia (HP:0001959)1.90034794
72Type I transferrin isoform profile (HP:0003642)1.89789684
73Colon cancer (HP:0003003)1.89478720
74Postaxial foot polydactyly (HP:0001830)1.86597073
75Abnormality of the 1st metacarpal (HP:0010009)1.86563026
76Oligodactyly (hands) (HP:0001180)1.86411151
77Tubulointerstitial abnormality (HP:0001969)1.85574005
78Postaxial hand polydactyly (HP:0001162)1.85484444
79Cystic liver disease (HP:0006706)1.85293389
80Hypoplasia of the uterus (HP:0000013)1.84961635
81Pendular nystagmus (HP:0012043)1.82966915
82Abnormality of the labia minora (HP:0012880)1.82723096
83Meckel diverticulum (HP:0002245)1.82008485
84Adactyly (HP:0009776)1.80882389
85Abnormality of the ileum (HP:0001549)1.80556408
86Polyuria (HP:0000103)1.79283555
87Renal Fanconi syndrome (HP:0001994)1.78672653
88Abnormality of the prostate (HP:0008775)1.76763511
89IgG deficiency (HP:0004315)1.76080597
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75363623
91Abnormal protein N-linked glycosylation (HP:0012347)1.75363623
92Abnormal protein glycosylation (HP:0012346)1.75363623
93Abnormal glycosylation (HP:0012345)1.75363623
94IgM deficiency (HP:0002850)1.75166904
95Chronic hepatic failure (HP:0100626)1.73870408
96Dyschromatopsia (HP:0007641)1.73766150
97Methylmalonic aciduria (HP:0012120)1.72697755
98Aplastic anemia (HP:0001915)1.69104023
99Congenital hepatic fibrosis (HP:0002612)1.68244869
100Lactic acidosis (HP:0003128)1.67773765

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.17891799
2FRK3.39106367
3EIF2AK33.13041974
4NUAK12.87386895
5TNIK2.80869827
6BMPR1B2.44446104
7TAOK32.26101125
8TXK2.11827103
9TRIM282.11281550
10ERBB32.04804535
11MAPK131.92182137
12PINK11.83052697
13NTRK31.82742204
14GRK71.81451514
15MAP3K41.74463601
16WEE11.73175779
17EIF2AK21.68104972
18NEK11.66304076
19TLK11.64702828
20EIF2AK11.59940390
21PLK31.59633559
22GRK11.56694766
23ZAK1.55978535
24DYRK21.53747239
25BUB11.50357330
26PLK41.46573647
27TGFBR11.45137174
28BCKDK1.39829678
29VRK21.32476682
30ACVR1B1.28031233
31MUSK1.26395253
32SIK31.24709325
33TAF11.23860569
34PLK21.16951957
35SRPK11.13400747
36MKNK11.12322714
37TEC1.11429581
38MAP3K141.10128492
39ADRBK21.09217203
40WNK41.08698600
41RPS6KA41.03048487
42WNK31.02050479
43MARK10.98721741
44KIT0.98656497
45VRK10.98570803
46CCNB10.95048632
47AKT30.93570644
48MAPKAPK30.93014950
49TSSK60.90345966
50OXSR10.90211468
51STK390.89761307
52TIE10.84762572
53FGFR20.81425385
54BCR0.79319516
55TTK0.79224830
56MKNK20.76466864
57CSNK1G20.75469002
58MINK10.74306869
59BRSK20.73797056
60BMPR20.73113865
61CDK80.72894263
62INSRR0.72099491
63FLT30.71384336
64STK160.68881543
65IKBKE0.67894829
66CSNK1G10.58376129
67MAP2K70.57141136
68CDC70.56029759
69ADRBK10.54827811
70MAP4K10.54400946
71PLK10.54170037
72CSNK1G30.53338568
73EPHA30.50657622
74PAK30.49127812
75ATR0.48699434
76ITK0.48636914
77PASK0.48357324
78ATM0.46602887
79MARK30.45749106
80SIK20.45508971
81CASK0.44263636
82CSNK1A1L0.44128147
83PRKD30.43990814
84IGF1R0.40613470
85AURKB0.40527272
86RPS6KA50.40291691
87IKBKB0.40086555
88NEK20.39968585
89ABL10.39776887
90BTK0.38600670
91LYN0.38493726
92PRKCQ0.37767880
93MST40.37707519
94CDK30.36929050
95PRKCE0.34017499
96CHEK20.33952022
97FER0.32755817
98MAP2K60.32693012
99GRK50.31482760
100SYK0.30589600

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.49667011
2Proteasome_Homo sapiens_hsa030503.09602611
3Protein export_Homo sapiens_hsa030602.58643695
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57072010
5Allograft rejection_Homo sapiens_hsa053302.56738280
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.51571150
7Non-homologous end-joining_Homo sapiens_hsa034502.40733939
8Basal transcription factors_Homo sapiens_hsa030222.39915096
9Graft-versus-host disease_Homo sapiens_hsa053322.37326653
10Propanoate metabolism_Homo sapiens_hsa006402.36408588
11Autoimmune thyroid disease_Homo sapiens_hsa053202.33106899
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13478516
13RNA degradation_Homo sapiens_hsa030182.11151555
14Type I diabetes mellitus_Homo sapiens_hsa049402.09004117
15Fanconi anemia pathway_Homo sapiens_hsa034602.07417289
16Homologous recombination_Homo sapiens_hsa034402.06886892
17Phototransduction_Homo sapiens_hsa047442.01802705
18RNA polymerase_Homo sapiens_hsa030201.95059163
19Oxidative phosphorylation_Homo sapiens_hsa001901.93850607
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86471759
21Parkinsons disease_Homo sapiens_hsa050121.73684985
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69148523
23Butanoate metabolism_Homo sapiens_hsa006501.68404392
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62618278
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62607938
26One carbon pool by folate_Homo sapiens_hsa006701.53610014
27Primary immunodeficiency_Homo sapiens_hsa053401.49462953
28Antigen processing and presentation_Homo sapiens_hsa046121.33879127
29Base excision repair_Homo sapiens_hsa034101.31835686
30RNA transport_Homo sapiens_hsa030131.30181467
31Linoleic acid metabolism_Homo sapiens_hsa005911.26171688
32Nitrogen metabolism_Homo sapiens_hsa009101.25651248
33Mismatch repair_Homo sapiens_hsa034301.22474357
34Steroid biosynthesis_Homo sapiens_hsa001001.19831817
35Nucleotide excision repair_Homo sapiens_hsa034201.17616391
36Tryptophan metabolism_Homo sapiens_hsa003801.13457218
37Huntingtons disease_Homo sapiens_hsa050161.13448108
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11818999
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11390539
40Spliceosome_Homo sapiens_hsa030401.04518483
41Fatty acid elongation_Homo sapiens_hsa000621.01856134
42Purine metabolism_Homo sapiens_hsa002301.01408640
43Pyrimidine metabolism_Homo sapiens_hsa002401.00944336
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00825805
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96743609
46Peroxisome_Homo sapiens_hsa041460.94429391
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91692203
48Ether lipid metabolism_Homo sapiens_hsa005650.91670377
49Taste transduction_Homo sapiens_hsa047420.88138822
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87776693
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87233411
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.86557140
53Rheumatoid arthritis_Homo sapiens_hsa053230.86145831
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85646161
55Alzheimers disease_Homo sapiens_hsa050100.85262788
56Nicotine addiction_Homo sapiens_hsa050330.84301209
57Viral myocarditis_Homo sapiens_hsa054160.84245036
58Ribosome_Homo sapiens_hsa030100.78458078
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78260233
60Regulation of autophagy_Homo sapiens_hsa041400.77180314
61Olfactory transduction_Homo sapiens_hsa047400.76444315
62Selenocompound metabolism_Homo sapiens_hsa004500.74387438
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72863348
64Chemical carcinogenesis_Homo sapiens_hsa052040.69053749
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68837247
66DNA replication_Homo sapiens_hsa030300.62545351
67Fatty acid metabolism_Homo sapiens_hsa012120.62130800
68Arachidonic acid metabolism_Homo sapiens_hsa005900.61204574
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59387079
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58483768
71Metabolic pathways_Homo sapiens_hsa011000.56461190
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56023179
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.54875638
74Glutathione metabolism_Homo sapiens_hsa004800.53458398
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53325184
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53124584
77Fatty acid degradation_Homo sapiens_hsa000710.52599963
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52318564
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.51766233
80Herpes simplex infection_Homo sapiens_hsa051680.51676142
81Caffeine metabolism_Homo sapiens_hsa002320.50264016
82Hematopoietic cell lineage_Homo sapiens_hsa046400.48754049
83Staphylococcus aureus infection_Homo sapiens_hsa051500.48731143
84Glycerolipid metabolism_Homo sapiens_hsa005610.48421739
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47793221
86Fat digestion and absorption_Homo sapiens_hsa049750.47759896
87Systemic lupus erythematosus_Homo sapiens_hsa053220.43515867
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42773292
89Cell cycle_Homo sapiens_hsa041100.40804494
90Epstein-Barr virus infection_Homo sapiens_hsa051690.40188445
91Pyruvate metabolism_Homo sapiens_hsa006200.38836651
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38116681
93Leishmaniasis_Homo sapiens_hsa051400.36794439
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36747418
95Cardiac muscle contraction_Homo sapiens_hsa042600.36466215
96Serotonergic synapse_Homo sapiens_hsa047260.33581274
97Circadian entrainment_Homo sapiens_hsa047130.33526060
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31811840
99Fatty acid biosynthesis_Homo sapiens_hsa000610.29065434
100Retinol metabolism_Homo sapiens_hsa008300.28368498

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