RPL18AP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of B cell apoptotic process (GO:0002903)5.52074836
2regulation of B cell apoptotic process (GO:0002902)5.45223881
3DNA deamination (GO:0045006)5.24592183
4ubiquinone biosynthetic process (GO:0006744)4.95526711
5regulation of regulatory T cell differentiation (GO:0045589)4.72302900
6positive regulation of alpha-beta T cell proliferation (GO:0046641)4.57356811
7regulation of T-helper 1 cell differentiation (GO:0045625)4.54607541
8tryptophan metabolic process (GO:0006568)4.51818865
9purine deoxyribonucleotide catabolic process (GO:0009155)4.50453103
10aspartate family amino acid catabolic process (GO:0009068)4.33493424
11ribosomal small subunit assembly (GO:0000028)4.29789067
12ubiquinone metabolic process (GO:0006743)4.28202891
13positive thymic T cell selection (GO:0045059)4.27863232
14negative regulation of thymocyte apoptotic process (GO:0070244)4.27189803
15positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.12189770
16quinone biosynthetic process (GO:1901663)4.07711788
17positive regulation of defense response to virus by host (GO:0002230)4.04764065
18indolalkylamine metabolic process (GO:0006586)4.02139484
19lysine catabolic process (GO:0006554)3.92353968
20lysine metabolic process (GO:0006553)3.92353968
21negative regulation of telomere maintenance (GO:0032205)3.88817950
22positive regulation of interleukin-17 production (GO:0032740)3.79199616
23positive regulation of B cell differentiation (GO:0045579)3.77349683
24response to interferon-beta (GO:0035456)3.74199343
25regulation of memory T cell differentiation (GO:0043380)3.72119449
26regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.67820805
27positive regulation of T cell cytokine production (GO:0002726)3.63443154
28aggressive behavior (GO:0002118)3.59525571
29histamine secretion (GO:0001821)3.54440689
30response to pheromone (GO:0019236)3.53156005
31regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.40841131
32cellular response to exogenous dsRNA (GO:0071360)3.40384663
33positive T cell selection (GO:0043368)3.39755811
34positive regulation of activated T cell proliferation (GO:0042104)3.37602644
35regulation of T-helper 1 type immune response (GO:0002825)3.36395129
36regulation of alpha-beta T cell proliferation (GO:0046640)3.35813046
37positive regulation of T-helper 1 type immune response (GO:0002827)3.30760816
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.28846249
39negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.27688309
40negative regulation of T-helper cell differentiation (GO:0045623)3.27688309
41water-soluble vitamin biosynthetic process (GO:0042364)3.23317163
42positive regulation of antigen processing and presentation (GO:0002579)3.22724151
43regulation of isotype switching to IgG isotypes (GO:0048302)3.21819433
44histamine transport (GO:0051608)3.20012707
45regulation of telomere maintenance via telomerase (GO:0032210)3.19836670
46piRNA metabolic process (GO:0034587)3.19006512
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.14121834
48regulation of penile erection (GO:0060405)3.11504342
49neural tube formation (GO:0001841)3.10224533
50regulation of immunoglobulin secretion (GO:0051023)3.08761240
51negative regulation of lymphocyte apoptotic process (GO:0070229)3.08658897
52purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.07246088
53deoxyribose phosphate catabolic process (GO:0046386)3.06579661
54purine deoxyribonucleotide metabolic process (GO:0009151)3.05997773
55regulation of interleukin-17 production (GO:0032660)3.05930703
56pseudouridine synthesis (GO:0001522)3.05180364
57branched-chain amino acid catabolic process (GO:0009083)3.04882062
58negative T cell selection (GO:0043383)3.01024177
59deoxyribonucleotide catabolic process (GO:0009264)3.00316261
60positive regulation of chemokine secretion (GO:0090197)2.94241845
61base-excision repair, AP site formation (GO:0006285)2.93518845
62quinone metabolic process (GO:1901661)2.92927533
63regulation of thymocyte apoptotic process (GO:0070243)2.90114776
64RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.85425475
65negative thymic T cell selection (GO:0045060)2.83914602
66regulation of antigen processing and presentation (GO:0002577)2.83654189
67positive regulation of isotype switching (GO:0045830)2.83104409
68B cell mediated immunity (GO:0019724)2.82089097
69cellular response to ATP (GO:0071318)2.82000148
70positive regulation of prostaglandin secretion (GO:0032308)2.80220687
71RNA destabilization (GO:0050779)2.77809447
72positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.77591214
73positive regulation of T-helper cell differentiation (GO:0045624)2.76807086
74regulation of defense response to virus by host (GO:0050691)2.74355935
75positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.74069306
76regulation of chemokine secretion (GO:0090196)2.71908643
77immunoglobulin mediated immune response (GO:0016064)2.69966191
78somatic hypermutation of immunoglobulin genes (GO:0016446)2.66295081
79somatic diversification of immune receptors via somatic mutation (GO:0002566)2.66295081
80positive regulation of DNA recombination (GO:0045911)2.63872445
81branched-chain amino acid metabolic process (GO:0009081)2.63857871
82ketone biosynthetic process (GO:0042181)2.62434784
83positive regulation of T cell differentiation in thymus (GO:0033089)2.61725440
84positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.61290563
85chaperone mediated protein folding requiring cofactor (GO:0051085)2.61093005
86L-fucose catabolic process (GO:0042355)2.59765464
87fucose catabolic process (GO:0019317)2.59765464
88L-fucose metabolic process (GO:0042354)2.59765464
89maturation of 5.8S rRNA (GO:0000460)2.59499362
90negative regulation of alpha-beta T cell differentiation (GO:0046639)2.58987618
91cytidine metabolic process (GO:0046087)2.57493767
92cytidine catabolic process (GO:0006216)2.57493767
93cytidine deamination (GO:0009972)2.57493767
94rRNA modification (GO:0000154)2.56714280
95regulation of germinal center formation (GO:0002634)2.55235187
96RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.55044876
97tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.55044876
98maturation of SSU-rRNA (GO:0030490)2.53786788
99regulation of lymphocyte apoptotic process (GO:0070228)2.53176161
100regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.52852166

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.44555660
2ZNF274_21170338_ChIP-Seq_K562_Hela3.83056612
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.48212906
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.32258018
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.15587693
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11564050
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.06901731
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.06728439
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.89512028
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.88539151
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.75961167
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51909107
13VDR_23849224_ChIP-Seq_CD4+_Human2.43404856
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.42706690
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41863230
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37183703
17CIITA_25753668_ChIP-Seq_RAJI_Human2.25849203
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.25052343
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22406795
20IGF1R_20145208_ChIP-Seq_DFB_Human2.05771153
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.03944117
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98068145
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.94338577
24FOXP3_21729870_ChIP-Seq_TREG_Human1.92215901
25EWS_26573619_Chip-Seq_HEK293_Human1.88377737
26GATA3_26560356_Chip-Seq_TH2_Human1.77387137
27VDR_22108803_ChIP-Seq_LS180_Human1.74766078
28ELK1_19687146_ChIP-ChIP_HELA_Human1.73615027
29MYC_18940864_ChIP-ChIP_HL60_Human1.72575601
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.70570472
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.70148099
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65279363
33EZH2_22144423_ChIP-Seq_EOC_Human1.59954981
34AR_20517297_ChIP-Seq_VCAP_Human1.56738805
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.52130418
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50706045
37MYB_26560356_Chip-Seq_TH2_Human1.44909184
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40203901
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38123429
40FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35073952
41GATA3_21878914_ChIP-Seq_MCF-7_Human1.34901695
42TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.34771611
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.33672697
44BCL6_27268052_Chip-Seq_Bcells_Human1.30233667
45TP53_22573176_ChIP-Seq_HFKS_Human1.29771325
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29532665
47PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.28651704
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.28299137
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28299137
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26990023
51SCL_19346495_ChIP-Seq_HPC-7_Human1.26246442
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26059071
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26015904
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25645991
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25257823
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22670321
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22542983
58SPI1_23547873_ChIP-Seq_NB4_Human1.22301629
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19828157
60GATA3_27048872_Chip-Seq_THYMUS_Human1.19208653
61ER_23166858_ChIP-Seq_MCF-7_Human1.19099107
62NANOG_19829295_ChIP-Seq_ESCs_Human1.18311361
63SOX2_19829295_ChIP-Seq_ESCs_Human1.18311361
64RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16525212
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15559727
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14769826
67CEBPB_22108803_ChIP-Seq_LS180_Human1.13881464
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.12777947
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10392382
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09773673
71ERG_20517297_ChIP-Seq_VCAP_Human1.09500896
72CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08934216
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07238916
74FUS_26573619_Chip-Seq_HEK293_Human1.06939750
75TAF2_19829295_ChIP-Seq_ESCs_Human1.06469960
76IRF1_19129219_ChIP-ChIP_H3396_Human1.04370675
77NANOG_20526341_ChIP-Seq_ESCs_Human1.04277235
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.04130259
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00028947
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99529122
81CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99417820
82GATA3_26560356_Chip-Seq_TH1_Human0.99193095
83EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98161434
84GATA6_21074721_ChIP-Seq_CACO-2_Human0.98089387
85FOXH1_21741376_ChIP-Seq_ESCs_Human0.97874551
86NCOR_22424771_ChIP-Seq_293T_Human0.96939566
87GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96775242
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95316274
89RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95215611
90ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94602081
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94544256
92ERA_21632823_ChIP-Seq_H3396_Human0.93933742
93P53_21459846_ChIP-Seq_SAOS-2_Human0.93545747
94HOXB7_26014856_ChIP-Seq_BT474_Human0.92618813
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91971445
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91960894
97CREB1_15753290_ChIP-ChIP_HEK293T_Human0.91788984
98CBP_20019798_ChIP-Seq_JUKART_Human0.90805627
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90805627
100E2F1_20622854_ChIP-Seq_HELA_Human0.90599697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.38122971
2MP0005646_abnormal_pituitary_gland3.80712755
3MP0003300_gastrointestinal_ulcer3.06741890
4MP0002166_altered_tumor_susceptibility2.81855319
5MP0006292_abnormal_olfactory_placode2.79276440
6MP0003724_increased_susceptibility_to2.73383735
7MP0001968_abnormal_touch/_nociception2.62842636
8MP0002138_abnormal_hepatobiliary_system2.62700845
9MP0002148_abnormal_hypersensitivity_rea2.60838493
10MP0009697_abnormal_copulation2.57697417
11MP0002006_tumorigenesis2.53304853
12MP0008872_abnormal_physiological_respon2.42962724
13MP0002736_abnormal_nociception_after2.26207236
14MP0001986_abnormal_taste_sensitivity2.15637478
15MP0003252_abnormal_bile_duct1.94563627
16MP0001800_abnormal_humoral_immune1.92072445
17MP0005000_abnormal_immune_tolerance1.83089337
18MP0003806_abnormal_nucleotide_metabolis1.79513713
19MP0000372_irregular_coat_pigmentation1.75552272
20MP0002277_abnormal_respiratory_mucosa1.70058988
21MP0008875_abnormal_xenobiotic_pharmacok1.69299553
22MP0000465_gastrointestinal_hemorrhage1.61529251
23MP0003646_muscle_fatigue1.61006234
24MP0002723_abnormal_immune_serum1.59994655
25MP0002876_abnormal_thyroid_physiology1.52106777
26MP0006072_abnormal_retinal_apoptosis1.51135555
27MP0006036_abnormal_mitochondrial_physio1.51012871
28MP0005671_abnormal_response_to1.48522136
29MP0010155_abnormal_intestine_physiology1.47534116
30MP0002452_abnormal_antigen_presenting1.44242512
31MP0000604_amyloidosis1.39912735
32MP0003866_abnormal_defecation1.35612922
33MP0001764_abnormal_homeostasis1.35365552
34MP0004145_abnormal_muscle_electrophysio1.33823213
35MP0003436_decreased_susceptibility_to1.31365254
36MP0006035_abnormal_mitochondrial_morpho1.30384007
37MP0002420_abnormal_adaptive_immunity1.30328188
38MP0002837_dystrophic_cardiac_calcinosis1.28214747
39MP0001819_abnormal_immune_cell1.27245777
40MP0009764_decreased_sensitivity_to1.25191186
41MP0004147_increased_porphyrin_level1.23193978
42MP0008877_abnormal_DNA_methylation1.22736647
43MP0005410_abnormal_fertilization1.21049756
44MP0008058_abnormal_DNA_repair1.20590663
45MP0000678_abnormal_parathyroid_gland1.17684297
46MP0003718_maternal_effect1.15450556
47MP0008775_abnormal_heart_ventricle1.14891857
48MP0003011_delayed_dark_adaptation1.13942654
49MP0001790_abnormal_immune_system1.13237604
50MP0005387_immune_system_phenotype1.13237604
51MP0008469_abnormal_protein_level1.13162419
52MP0003786_premature_aging1.12811083
53MP0001853_heart_inflammation1.12703626
54MP0005551_abnormal_eye_electrophysiolog1.11996210
55MP0002282_abnormal_trachea_morphology1.11621241
56MP0004782_abnormal_surfactant_physiolog1.09736989
57MP0005464_abnormal_platelet_physiology1.09119349
58MP0002398_abnormal_bone_marrow1.08294664
59MP0000230_abnormal_systemic_arterial1.07836605
60MP0000716_abnormal_immune_system1.04911404
61MP0003186_abnormal_redox_activity1.03947841
62MP0002009_preneoplasia1.03133807
63MP0005084_abnormal_gallbladder_morpholo1.02939822
64MP0005319_abnormal_enzyme/_coenzyme1.02802537
65MP0002160_abnormal_reproductive_system1.02391702
66MP0002419_abnormal_innate_immunity1.02145721
67MP0000427_abnormal_hair_cycle1.01200715
68MP0002234_abnormal_pharynx_morphology0.99051837
69MP0000689_abnormal_spleen_morphology0.98914562
70MP0001845_abnormal_inflammatory_respons0.96460601
71MP0009785_altered_susceptibility_to0.95181329
72MP0002132_abnormal_respiratory_system0.94120763
73MP0005332_abnormal_amino_acid0.92967188
74MP0010368_abnormal_lymphatic_system0.92922504
75MP0001984_abnormal_olfaction0.90515680
76MP0001765_abnormal_ion_homeostasis0.89958603
77MP0005167_abnormal_blood-brain_barrier0.89342027
78MP0005389_reproductive_system_phenotype0.89182425
79MP0004808_abnormal_hematopoietic_stem0.87948917
80MP0005253_abnormal_eye_physiology0.86925198
81MP0002429_abnormal_blood_cell0.86864698
82MP0002722_abnormal_immune_system0.84252992
83MP0009643_abnormal_urine_homeostasis0.82520278
84MP0001905_abnormal_dopamine_level0.82214249
85MP0001881_abnormal_mammary_gland0.81209238
86MP0005636_abnormal_mineral_homeostasis0.80796575
87MP0002405_respiratory_system_inflammati0.79478795
88MP0005025_abnormal_response_to0.78468977
89MP0003787_abnormal_imprinting0.77829228
90MP0002139_abnormal_hepatobiliary_system0.77485353
91MP0009379_abnormal_foot_pigmentation0.75384651
92MP0002933_joint_inflammation0.74916956
93MP0005075_abnormal_melanosome_morpholog0.74729630
94MP0008995_early_reproductive_senescence0.74602765
95MP0003763_abnormal_thymus_physiology0.72750625
96MP0001533_abnormal_skeleton_physiology0.72673671
97MP0002735_abnormal_chemical_nociception0.71086155
98MP0010329_abnormal_lipoprotein_level0.70194267
99MP0004215_abnormal_myocardial_fiber0.69177179
100MP0005365_abnormal_bile_salt0.68895303

Predicted human phenotypes

RankGene SetZ-score
1Panhypogammaglobulinemia (HP:0003139)5.94830173
2Agammaglobulinemia (HP:0004432)4.87906336
3Elevated erythrocyte sedimentation rate (HP:0003565)4.70271220
4Abnormality of B cell number (HP:0010975)4.50800833
5Mesangial abnormality (HP:0001966)4.32839221
6Aplastic anemia (HP:0001915)3.93082420
7B lymphocytopenia (HP:0010976)3.88273407
8Severe combined immunodeficiency (HP:0004430)3.79800184
9Oral leukoplakia (HP:0002745)3.71078371
10Hypoproteinemia (HP:0003075)3.46233666
11Abnormality of the prostate (HP:0008775)3.17476990
12Autoimmune hemolytic anemia (HP:0001890)3.16979695
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.13507411
14Thyroiditis (HP:0100646)3.10842767
15Hyperglycinuria (HP:0003108)3.04032276
16Combined immunodeficiency (HP:0005387)2.92406601
17Colon cancer (HP:0003003)2.87955848
18Abnormality of the renal cortex (HP:0011035)2.83928184
19Thrombocytosis (HP:0001894)2.83531435
20Autoimmune thrombocytopenia (HP:0001973)2.82414097
21Pancytopenia (HP:0001876)2.81812678
22Pancreatic cysts (HP:0001737)2.81588122
23Encephalitis (HP:0002383)2.72903739
24Stomach cancer (HP:0012126)2.65799664
25Abolished electroretinogram (ERG) (HP:0000550)2.63762290
263-Methylglutaconic aciduria (HP:0003535)2.63690976
27IgG deficiency (HP:0004315)2.60199100
28Stomatitis (HP:0010280)2.59787934
29Progressive inability to walk (HP:0002505)2.58182269
30Ketosis (HP:0001946)2.56064454
31Renal cortical cysts (HP:0000803)2.53665257
32Eosinophilia (HP:0001880)2.50880876
33Opisthotonus (HP:0002179)2.48221676
34Abnormality of lateral ventricle (HP:0030047)2.48105416
35Polydipsia (HP:0001959)2.43594672
36Abnormal drinking behavior (HP:0030082)2.43594672
37Abnormal number of erythroid precursors (HP:0012131)2.42231545
38Chronic otitis media (HP:0000389)2.37264252
39Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36775068
40Dicarboxylic aciduria (HP:0003215)2.36775068
41Abnormality of cells of the erythroid lineage (HP:0012130)2.36194554
42Testicular atrophy (HP:0000029)2.36044333
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.33231525
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.33231525
45Tubular atrophy (HP:0000092)2.29789526
46Granulocytopenia (HP:0001913)2.25402530
47Spontaneous abortion (HP:0005268)2.25133682
48Abnormality of T cell physiology (HP:0011840)2.24851630
49Congenital stationary night blindness (HP:0007642)2.24637512
50Chronic mucocutaneous candidiasis (HP:0002728)2.23395361
51Recurrent cutaneous fungal infections (HP:0011370)2.23395361
52Type II lissencephaly (HP:0007260)2.21451663
53Asplenia (HP:0001746)2.19295221
54Abnormality of the renal medulla (HP:0100957)2.19051666
55Aplasia/Hypoplasia of the spleen (HP:0010451)2.18431263
56Dry hair (HP:0011359)2.18208266
57Abnormality of glycine metabolism (HP:0010895)2.18144035
58Abnormality of serine family amino acid metabolism (HP:0010894)2.18144035
59Attenuation of retinal blood vessels (HP:0007843)2.15266416
60Abnormal biliary tract physiology (HP:0012439)2.14910661
61Bile duct proliferation (HP:0001408)2.14910661
62Amaurosis fugax (HP:0100576)2.14811638
63Pancreatic fibrosis (HP:0100732)2.14272068
64Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13845046
65Abnormality of eosinophils (HP:0001879)2.10783601
66Mitochondrial inheritance (HP:0001427)2.09967209
67Malignant hyperthermia (HP:0002047)2.09763819
68Rough bone trabeculation (HP:0100670)2.08054590
69Congenital, generalized hypertrichosis (HP:0004540)2.07327024
70Acute necrotizing encephalopathy (HP:0006965)2.06750580
71Recurrent viral infections (HP:0004429)2.05726677
72Nephronophthisis (HP:0000090)2.00936076
73Prostate neoplasm (HP:0100787)2.00586740
74Increased intramyocellular lipid droplets (HP:0012240)1.99670567
75Azoospermia (HP:0000027)1.99012819
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97051370
77Increased CSF lactate (HP:0002490)1.95897335
78Progressive macrocephaly (HP:0004481)1.95682730
79Abnormal mitochondria in muscle tissue (HP:0008316)1.94857119
80Abnormality of T cells (HP:0002843)1.94218917
81Renal Fanconi syndrome (HP:0001994)1.93632849
82Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93143279
83Recurrent fungal infections (HP:0002841)1.93026995
84Abnormal spermatogenesis (HP:0008669)1.92024330
85Polyuria (HP:0000103)1.89177780
86Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87283242
87Facial diplegia (HP:0001349)1.85725165
88Optic disc pallor (HP:0000543)1.85565856
89Abnormality of male internal genitalia (HP:0000022)1.84758837
90Abnormal rod and cone electroretinograms (HP:0008323)1.82881614
91Chronic diarrhea (HP:0002028)1.82322272
92Retinal dysplasia (HP:0007973)1.81406264
93Alveolar cell carcinoma (HP:0006519)1.81346378
94Spastic diplegia (HP:0001264)1.80673755
95Increased hepatocellular lipid droplets (HP:0006565)1.80531229
96Increased serum lactate (HP:0002151)1.77420749
97IgM deficiency (HP:0002850)1.74558344
98Lipid accumulation in hepatocytes (HP:0006561)1.74446259
99Hepatic necrosis (HP:0002605)1.73295131
100Hypomagnesemia (HP:0002917)1.71701161

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.52478054
2BMPR1B3.37652859
3TEC3.22669120
4BCKDK3.04976669
5EIF2AK32.85269088
6STK162.80403812
7ITK2.57299205
8TAOK32.45110394
9TLK12.32888729
10KIT2.26623389
11GRK12.06882292
12FES1.99962214
13CDK81.99069444
14VRK21.97719892
15NUAK11.81508960
16TGFBR11.81266216
17BTK1.76107787
18ADRBK21.65015125
19ZAK1.61948467
20MAP3K131.53858344
21BMPR21.53726483
22TXK1.52969862
23WNK41.52687739
24EIF2AK11.50382006
25TNK21.47542365
26TBK11.47356799
27SYK1.45760223
28IKBKE1.43363794
29FLT31.40832557
30MAPKAPK31.36563955
31OXSR11.36533178
32MAP4K11.36264351
33KDR1.33904411
34MAP3K141.29040647
35SCYL21.27227342
36PINK11.26119354
37PLK21.24625261
38GRK61.20898243
39WNK11.18079282
40STK391.12282877
41EIF2AK21.06318135
42VRK11.05357975
43IKBKB1.05109512
44MAPKAPK50.96491509
45CAMKK20.95980790
46ZAP700.95772320
47SRPK10.92370387
48LCK0.89490594
49LYN0.86856949
50TRPM70.86051097
51MAP2K30.85675912
52CDK190.82334136
53IRAK40.82091668
54MAP3K70.81705655
55TIE10.80758839
56MAP2K60.78231173
57PLK30.75471254
58MAPK130.74703276
59ACVR1B0.73695716
60TRIM280.70242787
61RPS6KA50.69885034
62PIM10.68938092
63CLK10.68230090
64ADRBK10.66941637
65RIPK40.66543437
66INSRR0.65629774
67GRK50.64498283
68FGFR20.64212219
69PLK40.63485094
70PBK0.61669111
71MAP3K50.61422009
72ATR0.61078703
73CSF1R0.58484729
74ABL10.58204799
75NME20.57303021
76PHKG20.56656665
77PHKG10.56656665
78IGF1R0.55332186
79MAP2K20.51664554
80PRKCQ0.51160958
81ERBB30.50330116
82TESK20.47706093
83TSSK60.45918554
84CSNK1G30.45061338
85JAK30.43501799
86MAP4K20.42908841
87DAPK20.42572999
88PIM20.41927715
89HCK0.39635188
90RPS6KB20.39477963
91PIK3CA0.39155028
92MKNK10.38065761
93MAP3K110.37741859
94PIK3CG0.37503615
95CSNK1G20.35260604
96PRKCA0.34099848
97CDK90.33831955
98CHUK0.33805476
99ABL20.31983013
100EGFR0.30900889

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.40665977
2Allograft rejection_Homo sapiens_hsa053303.94957406
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.91062860
4Autoimmune thyroid disease_Homo sapiens_hsa053203.76548493
5Graft-versus-host disease_Homo sapiens_hsa053323.67892904
6Type I diabetes mellitus_Homo sapiens_hsa049403.13877934
7Primary immunodeficiency_Homo sapiens_hsa053402.89772651
8Proteasome_Homo sapiens_hsa030502.63178715
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.40879919
10Antigen processing and presentation_Homo sapiens_hsa046122.38983439
11Ribosome_Homo sapiens_hsa030102.19477297
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.09576948
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80188242
14Oxidative phosphorylation_Homo sapiens_hsa001901.63571803
15Rheumatoid arthritis_Homo sapiens_hsa053231.63394544
16Staphylococcus aureus infection_Homo sapiens_hsa051501.55554464
17Linoleic acid metabolism_Homo sapiens_hsa005911.54927521
18Homologous recombination_Homo sapiens_hsa034401.50181756
19Parkinsons disease_Homo sapiens_hsa050121.49004335
20Tryptophan metabolism_Homo sapiens_hsa003801.45796571
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45329000
22Protein export_Homo sapiens_hsa030601.42893020
23Leishmaniasis_Homo sapiens_hsa051401.40646210
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38047266
25Nitrogen metabolism_Homo sapiens_hsa009101.37450839
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35175416
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29249331
28Viral myocarditis_Homo sapiens_hsa054161.24342088
29Non-homologous end-joining_Homo sapiens_hsa034501.21743357
30Phototransduction_Homo sapiens_hsa047441.18729595
31Ether lipid metabolism_Homo sapiens_hsa005651.17970095
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17508086
33RNA polymerase_Homo sapiens_hsa030201.14735885
34Arachidonic acid metabolism_Homo sapiens_hsa005901.13793178
35Hematopoietic cell lineage_Homo sapiens_hsa046401.12305048
36Peroxisome_Homo sapiens_hsa041461.08370570
37Systemic lupus erythematosus_Homo sapiens_hsa053221.06673665
38Basal transcription factors_Homo sapiens_hsa030221.01793662
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99015848
40NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98073117
41Base excision repair_Homo sapiens_hsa034100.96890752
42Fanconi anemia pathway_Homo sapiens_hsa034600.94763145
43Mismatch repair_Homo sapiens_hsa034300.93135310
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91375192
45Pyrimidine metabolism_Homo sapiens_hsa002400.86764272
46RNA degradation_Homo sapiens_hsa030180.84969881
47One carbon pool by folate_Homo sapiens_hsa006700.84452347
48Herpes simplex infection_Homo sapiens_hsa051680.80407479
49Chemical carcinogenesis_Homo sapiens_hsa052040.79575771
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74087995
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71891973
52Alzheimers disease_Homo sapiens_hsa050100.69531240
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69503700
54Fatty acid elongation_Homo sapiens_hsa000620.68618705
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.68145062
56Huntingtons disease_Homo sapiens_hsa050160.66012962
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65394270
58Propanoate metabolism_Homo sapiens_hsa006400.64783546
59DNA replication_Homo sapiens_hsa030300.64535399
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64334703
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63060209
62Nucleotide excision repair_Homo sapiens_hsa034200.62354304
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.62028980
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60565072
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.60327051
66Selenocompound metabolism_Homo sapiens_hsa004500.59748534
67Caffeine metabolism_Homo sapiens_hsa002320.58638030
68Fatty acid degradation_Homo sapiens_hsa000710.58541382
69Spliceosome_Homo sapiens_hsa030400.57365089
70Cardiac muscle contraction_Homo sapiens_hsa042600.53255091
71T cell receptor signaling pathway_Homo sapiens_hsa046600.52104911
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.51279658
73Purine metabolism_Homo sapiens_hsa002300.50194653
74RNA transport_Homo sapiens_hsa030130.49645910
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49364933
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48664256
77Butanoate metabolism_Homo sapiens_hsa006500.48428983
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48327879
79Tuberculosis_Homo sapiens_hsa051520.46579666
80Olfactory transduction_Homo sapiens_hsa047400.45395862
81Retinol metabolism_Homo sapiens_hsa008300.44811117
82Metabolic pathways_Homo sapiens_hsa011000.42673908
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41402297
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.38962349
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.38446923
86Fat digestion and absorption_Homo sapiens_hsa049750.36275778
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34247750
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32104736
89Sulfur metabolism_Homo sapiens_hsa009200.31616968
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31606274
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28970734
92Influenza A_Homo sapiens_hsa051640.28632309
93Toxoplasmosis_Homo sapiens_hsa051450.27953074
94Glycerolipid metabolism_Homo sapiens_hsa005610.27863163
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26906697
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.26834137
97Measles_Homo sapiens_hsa051620.26449608
98Ovarian steroidogenesis_Homo sapiens_hsa049130.24293620
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23550767
100Epstein-Barr virus infection_Homo sapiens_hsa051690.21809567

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »