ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	9.31545438
2	nucleobase catabolic process (GO:0046113)	7.35112222
3	protein K11-linked deubiquitination (GO:0035871)	4.66488095
4	limb bud formation (GO:0060174)	4.54892530
5	regulation of glucokinase activity (GO:0033131)	4.46883747
6	regulation of hexokinase activity (GO:1903299)	4.46883747
7	negative regulation of dendrite development (GO:2000171)	4.33551824
8	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	4.28391565
9	UMP biosynthetic process (GO:0006222)	4.28391565
10	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	4.28391565
11	UMP metabolic process (GO:0046049)	4.28391565
12	presynaptic membrane assembly (GO:0097105)	4.24262010
13	lactate metabolic process (GO:0006089)	4.19023627
14	regulation of cardiac muscle cell contraction (GO:0086004)	3.96255360
15	piRNA metabolic process (GO:0034587)	3.92390412
16	negative regulation of neurological system process (GO:0031645)	3.87026635
17	response to methylmercury (GO:0051597)	3.82789837
18	platelet dense granule organization (GO:0060155)	3.74943553
19	DNA deamination (GO:0045006)	3.74135933
20	negative regulation of dendrite morphogenesis (GO:0050774)	3.56560743
21	neural tube formation (GO:0001841)	3.54340478
22	sympathetic nervous system development (GO:0048485)	3.52873615
23	DNA integration (GO:0015074)	3.52315115
24	regulation of feeding behavior (GO:0060259)	3.48439927
25	presynaptic membrane organization (GO:0097090)	3.45811461
26	brain morphogenesis (GO:0048854)	3.41173484
27	regulation of DNA endoreduplication (GO:0032875)	3.39530534
28	ganglion development (GO:0061548)	3.38127088
29	glycosphingolipid biosynthetic process (GO:0006688)	3.37212419
30	regulation of protein glycosylation (GO:0060049)	3.35544392
31	DNA double-strand break processing (GO:0000729)	3.32370978
32	central nervous system neuron axonogenesis (GO:0021955)	3.30663240
33	retinal rod cell development (GO:0046548)	3.21179882
34	inositol phosphate catabolic process (GO:0071545)	3.19249307
35	regulation of relaxation of muscle (GO:1901077)	3.17846600
36	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.16751352
37	keratinocyte development (GO:0003334)	3.15164438
38	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.13045227
39	olfactory bulb development (GO:0021772)	3.11670576
40	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.06240085
41	response to pheromone (GO:0019236)	3.06115388
42	cornea development in camera-type eye (GO:0061303)	3.03497138
43	histone H2A acetylation (GO:0043968)	2.98755531
44	polyol catabolic process (GO:0046174)	2.98424017
45	retinal ganglion cell axon guidance (GO:0031290)	2.97652020
46	sialylation (GO:0097503)	2.97215581
47	photoreceptor cell maintenance (GO:0045494)	2.95880360
48	regulation of cilium movement (GO:0003352)	2.95609459
49	regulation of actin filament-based movement (GO:1903115)	2.91255593
50	intraciliary transport (GO:0042073)	2.90432633
51	detection of light stimulus involved in sensory perception (GO:0050962)	2.89089439
52	detection of light stimulus involved in visual perception (GO:0050908)	2.89089439
53	glial cell proliferation (GO:0014009)	2.89061545
54	zinc ion transport (GO:0006829)	2.85874616
55	central nervous system projection neuron axonogenesis (GO:0021952)	2.85809307
56	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.84169900
57	acrosome assembly (GO:0001675)	2.83678838
58	postsynaptic membrane organization (GO:0001941)	2.83624794
59	behavioral response to nicotine (GO:0035095)	2.82742034
60	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.79874243
61	DNA methylation involved in gamete generation (GO:0043046)	2.78330782
62	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	2.77730695
63	regulation of dendritic spine morphogenesis (GO:0061001)	2.76590067
64	cilium morphogenesis (GO:0060271)	2.71475473
65	cytochrome complex assembly (GO:0017004)	2.71153550
66	retinal cone cell development (GO:0046549)	2.70676275
67	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.69350089
68	cyclic nucleotide catabolic process (GO:0009214)	2.69338894
69	protein localization to cilium (GO:0061512)	2.68869215
70	respiratory chain complex IV assembly (GO:0008535)	2.68555049
71	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.66968271
72	negative regulation of membrane potential (GO:0045837)	2.66802138
73	cAMP catabolic process (GO:0006198)	2.66478875
74	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.65432440
75	positive regulation of protein autophosphorylation (GO:0031954)	2.60458982
76	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.60434983
77	inositol phosphate dephosphorylation (GO:0046855)	2.60434983
78	membrane invagination (GO:0010324)	2.59675171
79	regulation of male gonad development (GO:2000018)	2.55991914
80	positive regulation of glycoprotein metabolic process (GO:1903020)	2.55456416
81	transepithelial transport (GO:0070633)	2.55160035
82	multicellular organism reproduction (GO:0032504)	2.55056202
83	rRNA catabolic process (GO:0016075)	2.54691184
84	cellular response to interleukin-15 (GO:0071350)	2.53228727
85	regulation of dendritic spine development (GO:0060998)	2.52996355
86	cilium organization (GO:0044782)	2.52604215
87	neuron cell-cell adhesion (GO:0007158)	2.51256884
88	regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)	2.50586536
89	mechanosensory behavior (GO:0007638)	2.47522888
90	protein polyglutamylation (GO:0018095)	2.46544057
91	atrial cardiac muscle cell action potential (GO:0086014)	2.45715942
92	cilium assembly (GO:0042384)	2.43506060
93	phospholipid homeostasis (GO:0055091)	2.43304690
94	dopamine transport (GO:0015872)	2.41672350
95	pyrimidine-containing compound catabolic process (GO:0072529)	2.41036780
96	double-strand break repair via homologous recombination (GO:0000724)	2.40514403
97	DNA replication-dependent nucleosome organization (GO:0034723)	2.38709108
98	DNA replication-dependent nucleosome assembly (GO:0006335)	2.38709108
99	recombinational repair (GO:0000725)	2.37420994
100	DNA damage response, detection of DNA damage (GO:0042769)	2.37264875

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.55156740
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.47062322
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.16514183
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.05540234
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.02148616
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.93893048
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.88897391
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.70163561
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.62696203
10	FUS_26573619_Chip-Seq_HEK293_Human	2.58730522
11	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.35017786
12	VDR_22108803_ChIP-Seq_LS180_Human	2.29690882
13	EWS_26573619_Chip-Seq_HEK293_Human	2.17369255
14	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.16964059
15	P300_19829295_ChIP-Seq_ESCs_Human	2.15833657
16	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.13805068
17	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.13087759
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08560408
19	TAF15_26573619_Chip-Seq_HEK293_Human	2.08226367
20	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.88401000
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.87522788
22	SMAD4_21799915_ChIP-Seq_A2780_Human	1.83481066
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81759784
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.78252159
25	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.75071012
26	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.72597499
27	STAT3_23295773_ChIP-Seq_U87_Human	1.69647057
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.67811743
29	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.64892406
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63179335
31	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62085124
32	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.61503915
33	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.55655538
34	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.54814654
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.53307357
36	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.51134112
37	TCF4_23295773_ChIP-Seq_U87_Human	1.50129661
38	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.47310302
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.46046815
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46046815
41	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.45763469
42	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.45524813
43	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.44682442
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.41727020
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.37316266
46	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.35924239
47	RUNX2_22187159_ChIP-Seq_PCA_Human	1.35240731
48	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.34110779
49	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.33034111
50	TCF4_22108803_ChIP-Seq_LS180_Human	1.32540891
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32385802
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30987128
53	AR_25329375_ChIP-Seq_VCAP_Human	1.29897655
54	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.29646780
55	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28212254
56	ELK1_19687146_ChIP-ChIP_HELA_Human	1.28130315
57	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.27573411
58	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.27185537
59	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.25886342
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25886342
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25515523
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25515523
63	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.25514827
64	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.23274601
65	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.22742188
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22432177
67	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.21925777
68	P53_22387025_ChIP-Seq_ESCs_Mouse	1.21537757
69	P300_18555785_Chip-Seq_ESCs_Mouse	1.20743788
70	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20325795
71	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.18855111
72	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.18288484
73	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.18118709
74	TP53_18474530_ChIP-ChIP_U2OS_Human	1.17784650
75	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.17132512
76	TP53_22573176_ChIP-Seq_HFKS_Human	1.16972112
77	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.16814609
78	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.15854720
79	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.14927268
80	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14840162
81	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.13223256
82	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12905808
83	CDX2_22108803_ChIP-Seq_LS180_Human	1.12257443
84	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11689242
85	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11545825
86	GATA3_26560356_Chip-Seq_TH2_Human	1.10888799
87	IRF1_19129219_ChIP-ChIP_H3396_Human	1.09935959
88	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.09913488
89	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.09809257
90	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.08975240
91	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.08626719
92	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.06859543
93	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.06774986
94	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.06774986
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03682392
96	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03577096
97	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.02131152
98	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.01032933
99	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.00386941
100	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.99514310

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.64795508
2	MP0000516_abnormal_urinary_system	3.55744527
3	MP0005367_renal/urinary_system_phenotyp	3.55744527
4	MP0002254_reproductive_system_inflammat	3.19414455
5	MP0001529_abnormal_vocalization	2.80721365
6	MP0000372_irregular_coat_pigmentation	2.77037198
7	MP0005171_absent_coat_pigmentation	2.70634045
8	MP0002736_abnormal_nociception_after	2.54787668
9	MP0005075_abnormal_melanosome_morpholog	2.24146148
10	MP0008872_abnormal_physiological_respon	2.23490332
11	MP0002638_abnormal_pupillary_reflex	2.16301683
12	MP0005253_abnormal_eye_physiology	2.10405471
13	MP0005670_abnormal_white_adipose	2.10139288
14	MP0003880_abnormal_central_pattern	2.10024814
15	MP0008877_abnormal_DNA_methylation	2.04902530
16	MP0003787_abnormal_imprinting	2.04297779
17	MP0002735_abnormal_chemical_nociception	2.03835866
18	MP0002822_catalepsy	1.92587410
19	MP0008789_abnormal_olfactory_epithelium	1.91706543
20	MP0001984_abnormal_olfaction	1.90396698
21	MP0004381_abnormal_hair_follicle	1.79794955
22	MP0002751_abnormal_autonomic_nervous	1.68129416
23	MP0005551_abnormal_eye_electrophysiolog	1.66823264
24	MP0002876_abnormal_thyroid_physiology	1.65022665
25	MP0002102_abnormal_ear_morphology	1.64630722
26	MP0001486_abnormal_startle_reflex	1.62939105
27	MP0006072_abnormal_retinal_apoptosis	1.61523857
28	MP0002909_abnormal_adrenal_gland	1.50205907
29	MP0002233_abnormal_nose_morphology	1.49862370
30	MP0001968_abnormal_touch/_nociception	1.46890270
31	MP0005379_endocrine/exocrine_gland_phen	1.45415249
32	MP0002163_abnormal_gland_morphology	1.44679148
33	MP0005386_behavior/neurological_phenoty	1.43419667
34	MP0004924_abnormal_behavior	1.43419667
35	MP0008058_abnormal_DNA_repair	1.40535626
36	MP0002095_abnormal_skin_pigmentation	1.40136408
37	MP0002282_abnormal_trachea_morphology	1.38741473
38	MP0006054_spinal_hemorrhage	1.38679038
39	MP0002166_altered_tumor_susceptibility	1.38078077
40	MP0003656_abnormal_erythrocyte_physiolo	1.35401897
41	MP0006276_abnormal_autonomic_nervous	1.34768776
42	MP0003786_premature_aging	1.32414577
43	MP0005310_abnormal_salivary_gland	1.32017860
44	MP0005394_taste/olfaction_phenotype	1.28355792
45	MP0005499_abnormal_olfactory_system	1.28355792
46	MP0002938_white_spotting	1.21947853
47	MP0000427_abnormal_hair_cycle	1.19866821
48	MP0005408_hypopigmentation	1.17181185
49	MP0003137_abnormal_impulse_conducting	1.13752214
50	MP0000538_abnormal_urinary_bladder	1.13386385
51	MP0008057_abnormal_DNA_replication	1.12285919
52	MP0009745_abnormal_behavioral_response	1.10262746
53	MP0000778_abnormal_nervous_system	1.09316160
54	MP0002653_abnormal_ependyma_morphology	1.08233429
55	MP0000371_diluted_coat_color	1.07027464
56	MP0002837_dystrophic_cardiac_calcinosis	1.06746814
57	MP0002067_abnormal_sensory_capabilities	1.06624456
58	MP0001485_abnormal_pinna_reflex	1.04296013
59	MP0005084_abnormal_gallbladder_morpholo	1.01148695
60	MP0003011_delayed_dark_adaptation	1.00516817
61	MP0001501_abnormal_sleep_pattern	1.00142706
62	MP0002138_abnormal_hepatobiliary_system	0.99687142
63	MP0003718_maternal_effect	0.98580244
64	MP0005174_abnormal_tail_pigmentation	0.98193471
65	MP0000613_abnormal_salivary_gland	0.95997381
66	MP0003943_abnormal_hepatobiliary_system	0.95465323
67	MP0003195_calcinosis	0.91941875
68	MP0002090_abnormal_vision	0.90303627
69	MP0005410_abnormal_fertilization	0.90063261
70	MP0002168_other_aberrant_phenotype	0.90040872
71	MP0004270_analgesia	0.90006726
72	MP0004484_altered_response_of	0.89984647
73	MP0001324_abnormal_eye_pigmentation	0.89028585
74	MP0009046_muscle_twitch	0.88213528
75	MP0010234_abnormal_vibrissa_follicle	0.87669614
76	MP0005395_other_phenotype	0.86245846
77	MP0003755_abnormal_palate_morphology	0.85191963
78	MP0005645_abnormal_hypothalamus_physiol	0.84490909
79	MP0001970_abnormal_pain_threshold	0.80915838
80	MP0000647_abnormal_sebaceous_gland	0.79087309
81	MP0004147_increased_porphyrin_level	0.78394291
82	MP0004085_abnormal_heartbeat	0.76740644
83	MP0009697_abnormal_copulation	0.74896925
84	MP0005389_reproductive_system_phenotype	0.74701425
85	MP0001177_atelectasis	0.73708454
86	MP0008995_early_reproductive_senescence	0.73524587
87	MP0004142_abnormal_muscle_tone	0.72638602
88	MP0005391_vision/eye_phenotype	0.72031190
89	MP0002006_tumorigenesis	0.71664650
90	MP0003186_abnormal_redox_activity	0.70695504
91	MP0003121_genomic_imprinting	0.70128196
92	MP0003698_abnormal_male_reproductive	0.69931376
93	MP0002752_abnormal_somatic_nervous	0.68577570
94	MP0001764_abnormal_homeostasis	0.67689181
95	MP0002572_abnormal_emotion/affect_behav	0.67409438
96	MP0010094_abnormal_chromosome_stability	0.66035931
97	MP0001502_abnormal_circadian_rhythm	0.65469545
98	MP0002063_abnormal_learning/memory/cond	0.64982319
99	MP0003646_muscle_fatigue	0.64819834
100	MP0004742_abnormal_vestibular_system	0.63968534

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	3.87120295
2	Pancreatic cysts (HP:0001737)	3.41998344
3	Gaze-evoked nystagmus (HP:0000640)	3.40714458
4	Long clavicles (HP:0000890)	3.35074093
5	Tubulointerstitial nephritis (HP:0001970)	3.21586521
6	True hermaphroditism (HP:0010459)	3.21564345
7	Focal motor seizures (HP:0011153)	3.11286331
8	Thyroiditis (HP:0100646)	3.09444028
9	Chronic hepatic failure (HP:0100626)	3.08963653
10	Abnormality of midbrain morphology (HP:0002418)	3.07711737
11	Molar tooth sign on MRI (HP:0002419)	3.07711737
12	Hyperventilation (HP:0002883)	2.96944659
13	Medial flaring of the eyebrow (HP:0010747)	2.95227633
14	Abnormality of the labia minora (HP:0012880)	2.94886545
15	Absent speech (HP:0001344)	2.92907464
16	Intestinal atresia (HP:0011100)	2.91757704
17	Focal seizures (HP:0007359)	2.75463964
18	Fair hair (HP:0002286)	2.69658473
19	Median cleft lip (HP:0000161)	2.64979219
20	Abnormality of lateral ventricle (HP:0030047)	2.59139058
21	Abnormality of pyrimidine metabolism (HP:0004353)	2.57626489
22	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.50363534
23	Hypothermia (HP:0002045)	2.46366473
24	Congenital primary aphakia (HP:0007707)	2.44159401
25	Large for gestational age (HP:0001520)	2.43731602
26	Gait imbalance (HP:0002141)	2.42568145
27	Genital tract atresia (HP:0001827)	2.41160013
28	Abnormality of the renal medulla (HP:0100957)	2.37790093
29	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.36999650
30	Blue irides (HP:0000635)	2.36979478
31	Nephronophthisis (HP:0000090)	2.35690164
32	Generalized hypopigmentation of hair (HP:0011358)	2.32967990
33	Widely spaced teeth (HP:0000687)	2.31779027
34	Abnormality of the renal cortex (HP:0011035)	2.31227531
35	Progressive inability to walk (HP:0002505)	2.30795821
36	Nephrogenic diabetes insipidus (HP:0009806)	2.28826120
37	Short tibia (HP:0005736)	2.28724398
38	Amyotrophic lateral sclerosis (HP:0007354)	2.28037951
39	Postaxial hand polydactyly (HP:0001162)	2.25647028
40	Pancreatic islet-cell hyperplasia (HP:0004510)	2.25394397
41	Submucous cleft hard palate (HP:0000176)	2.22513853
42	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.22295721
43	Hypoplasia of the fovea (HP:0007750)	2.22295721
44	Hypokalemic alkalosis (HP:0001949)	2.21660770
45	Congenital stationary night blindness (HP:0007642)	2.21093907
46	Febrile seizures (HP:0002373)	2.18730050
47	Inability to walk (HP:0002540)	2.16171668
48	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.13343882
49	Tetraplegia (HP:0002445)	2.12470236
50	Gastrointestinal atresia (HP:0002589)	2.11754052
51	Postaxial foot polydactyly (HP:0001830)	2.11585062
52	Hepatoblastoma (HP:0002884)	2.11398832
53	Bifid tongue (HP:0010297)	2.11369832
54	Metaphyseal dysplasia (HP:0100255)	2.10836454
55	Congenital hepatic fibrosis (HP:0002612)	2.09314590
56	Oligodactyly (hands) (HP:0001180)	2.08050071
57	Cystic liver disease (HP:0006706)	2.07049713
58	Short 1st metacarpal (HP:0010034)	2.05728043
59	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.05728043
60	Progressive cerebellar ataxia (HP:0002073)	2.04052940
61	Dysdiadochokinesis (HP:0002075)	2.03845311
62	Hemiparesis (HP:0001269)	2.03184866
63	Chorioretinal atrophy (HP:0000533)	2.03086286
64	Aqueductal stenosis (HP:0002410)	2.02955005
65	Preaxial hand polydactyly (HP:0001177)	2.02744956
66	Abnormal biliary tract physiology (HP:0012439)	2.02555902
67	Bile duct proliferation (HP:0001408)	2.02555902
68	Abnormality of the metopic suture (HP:0005556)	1.96248095
69	Lissencephaly (HP:0001339)	1.95286740
70	Tubulointerstitial abnormality (HP:0001969)	1.91852426
71	Occipital encephalocele (HP:0002085)	1.91770993
72	Abolished electroretinogram (ERG) (HP:0000550)	1.90270851
73	Keratoconus (HP:0000563)	1.90152927
74	Increased corneal curvature (HP:0100692)	1.90152927
75	Pachygyria (HP:0001302)	1.89560780
76	Aplasia/Hypoplasia of the macula (HP:0008059)	1.88289448
77	Attenuation of retinal blood vessels (HP:0007843)	1.88086920
78	Progressive macrocephaly (HP:0004481)	1.87973328
79	Volvulus (HP:0002580)	1.87570899
80	Renal hypoplasia (HP:0000089)	1.86319997
81	Tubular atrophy (HP:0000092)	1.85530993
82	Muscular hypotonia of the trunk (HP:0008936)	1.84638242
83	Hyperinsulinemic hypoglycemia (HP:0000825)	1.82305716
84	Polyuria (HP:0000103)	1.81182828
85	Abnormality of the fovea (HP:0000493)	1.80366962
86	Hypoplastic labia majora (HP:0000059)	1.78933245
87	Abnormality of the labia majora (HP:0012881)	1.78212062
88	Vaginal atresia (HP:0000148)	1.77405054
89	Ketoacidosis (HP:0001993)	1.74865822
90	Broad-based gait (HP:0002136)	1.74527891
91	Abnormality of the 1st metacarpal (HP:0010009)	1.74439574
92	Megalencephaly (HP:0001355)	1.73440577
93	Retinal dysplasia (HP:0007973)	1.73218377
94	Type II lissencephaly (HP:0007260)	1.72239787
95	Chronic mucocutaneous candidiasis (HP:0002728)	1.71928600
96	Recurrent cutaneous fungal infections (HP:0011370)	1.71928600
97	Papillary thyroid carcinoma (HP:0002895)	1.70968628
98	Furrowed tongue (HP:0000221)	1.70725314
99	Hypomagnesemia (HP:0002917)	1.69866923
100	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.69707290

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.84433524
2	MAP4K2	4.34230573
3	TRIM28	3.55044357
4	BRSK2	3.41371183
5	MARK1	2.94835779
6	BCR	2.93082681
7	MST4	2.36890113
8	CASK	2.30165874
9	BMPR1B	2.12151575
10	EIF2AK3	2.04143977
11	SIK3	2.02419128
12	NUAK1	1.82607793
13	TIE1	1.81648004
14	WNK3	1.81530839
15	PINK1	1.80187142
16	ERBB3	1.74318865
17	MAPK13	1.70351800
18	FGFR2	1.69268223
19	WEE1	1.54201022
20	GRK1	1.52068676
21	CAMKK2	1.45968210
22	MAP3K4	1.42945650
23	PAK3	1.36078350
24	ACVR1B	1.26798274
25	STK39	1.24078725
26	AKT3	1.22714132
27	ADRBK2	1.21851939
28	CSNK1G2	1.14824164
29	CSNK1G3	1.10678572
30	BCKDK	1.10349678
31	MARK3	1.10182433
32	CSNK1A1L	1.09804668
33	CSNK1G1	1.06385485
34	OXSR1	1.02998366
35	STK38L	1.02199953
36	MAP3K3	0.96137241
37	DYRK1A	0.95023727
38	BRSK1	0.93015400
39	ZAK	0.85842346
40	TEC	0.84285171
41	MAP2K7	0.79638098
42	PKN1	0.79127991
43	BMPR2	0.77873463
44	ROCK1	0.76692870
45	MKNK2	0.75464517
46	DYRK3	0.75383047
47	YES1	0.73428997
48	FES	0.73334565
49	PRKCE	0.72733496
50	STK3	0.67711936
51	PLK3	0.66273521
52	TXK	0.65884723
53	PDK2	0.63155051
54	KSR1	0.61416613
55	PTK2B	0.59783216
56	CAMK1D	0.59525218
57	FER	0.59371096
58	SGK2	0.58554812
59	PIK3CG	0.58408918
60	CDK8	0.57002585
61	CLK1	0.56403450
62	ADRBK1	0.56314355
63	STK11	0.54160292
64	PBK	0.53637486
65	CCNB1	0.52931550
66	SRPK1	0.50795145
67	PHKG2	0.50758028
68	PHKG1	0.50758028
69	EPHA4	0.50713596
70	CSNK1D	0.49342668
71	MINK1	0.48183817
72	INSRR	0.48159070
73	DYRK2	0.48067243
74	PRKCQ	0.46981384
75	TAOK3	0.45044112
76	TYRO3	0.44625712
77	MAP3K7	0.41816241
78	STK38	0.40193472
79	IKBKB	0.39614924
80	PRKACA	0.39549558
81	CAMK4	0.38570518
82	PRKAA2	0.38389810
83	DAPK2	0.37357085
84	MKNK1	0.36651493
85	PRKCG	0.36563005
86	ATM	0.36049028
87	PRKCZ	0.33620652
88	FGFR3	0.33437429
89	VRK1	0.32756552
90	MAP3K14	0.32181732
91	CAMK1	0.32055667
92	CSNK1A1	0.31991773
93	ABL1	0.31674668
94	CAMK1G	0.28496818
95	MAPKAPK3	0.27000786
96	PLK2	0.26772690
97	BRD4	0.24814919
98	ATR	0.24736126
99	EGFR	0.24728324
100	SGK223	0.23712602

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	3.09200373
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.70346553
3	Non-homologous end-joining_Homo sapiens_hsa03450	2.60633298
4	beta-Alanine metabolism_Homo sapiens_hsa00410	2.49218930
5	Butanoate metabolism_Homo sapiens_hsa00650	2.44420151
6	Protein export_Homo sapiens_hsa03060	2.43927136
7	Propanoate metabolism_Homo sapiens_hsa00640	2.40487811
8	Circadian rhythm_Homo sapiens_hsa04710	2.36427042
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.35252416
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.30768284
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.23167293
12	Asthma_Homo sapiens_hsa05310	2.21919095
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.14985664
14	Phototransduction_Homo sapiens_hsa04744	2.06444578
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.90093831
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.86102276
17	Homologous recombination_Homo sapiens_hsa03440	1.85259426
18	Basal transcription factors_Homo sapiens_hsa03022	1.82800077
19	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.76136494
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.68507690
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.65243728
22	Allograft rejection_Homo sapiens_hsa05330	1.64346476
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.63326560
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.62257995
25	Regulation of autophagy_Homo sapiens_hsa04140	1.58469550
26	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.58380385
27	Graft-versus-host disease_Homo sapiens_hsa05332	1.48743140
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.44944755
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.44629275
30	RNA degradation_Homo sapiens_hsa03018	1.43276863
31	Caffeine metabolism_Homo sapiens_hsa00232	1.41311689
32	RNA polymerase_Homo sapiens_hsa03020	1.39690401
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.38226326
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.35144552
35	Lysine degradation_Homo sapiens_hsa00310	1.30140298
36	Nicotine addiction_Homo sapiens_hsa05033	1.26506351
37	Taste transduction_Homo sapiens_hsa04742	1.14895336
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.14169319
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.08893397
40	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.06407535
41	Olfactory transduction_Homo sapiens_hsa04740	1.04534737
42	Primary immunodeficiency_Homo sapiens_hsa05340	1.01764869
43	Retinol metabolism_Homo sapiens_hsa00830	0.99575651
44	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.90309496
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.85855145
46	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.82623388
47	Fatty acid degradation_Homo sapiens_hsa00071	0.76569769
48	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.75349239
49	Serotonergic synapse_Homo sapiens_hsa04726	0.75137489
50	Circadian entrainment_Homo sapiens_hsa04713	0.74552105
51	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.73309212
52	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.71201876
53	Salivary secretion_Homo sapiens_hsa04970	0.69385807
54	Insulin secretion_Homo sapiens_hsa04911	0.69380688
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67910256
56	Dopaminergic synapse_Homo sapiens_hsa04728	0.66925372
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.66648721
58	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.64973772
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.60591571
60	Peroxisome_Homo sapiens_hsa04146	0.59506313
61	Morphine addiction_Homo sapiens_hsa05032	0.58524884
62	Amphetamine addiction_Homo sapiens_hsa05031	0.57018162
63	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56873485
64	Glutamatergic synapse_Homo sapiens_hsa04724	0.56452011
65	Rheumatoid arthritis_Homo sapiens_hsa05323	0.56268480
66	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.53711672
67	Calcium signaling pathway_Homo sapiens_hsa04020	0.53454016
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48152139
69	Cholinergic synapse_Homo sapiens_hsa04725	0.47822400
70	Axon guidance_Homo sapiens_hsa04360	0.47787695
71	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.45495968
72	Antigen processing and presentation_Homo sapiens_hsa04612	0.45257456
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.44574466
74	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.43200565
75	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42642002
76	ABC transporters_Homo sapiens_hsa02010	0.42611541
77	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.42454523
78	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41276387
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.41130801
80	Purine metabolism_Homo sapiens_hsa00230	0.40921730
81	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.39793386
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.37209389
83	Pyruvate metabolism_Homo sapiens_hsa00620	0.36773931
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.35296464
85	Sphingolipid metabolism_Homo sapiens_hsa00600	0.34807940
86	Histidine metabolism_Homo sapiens_hsa00340	0.34713261
87	Fatty acid metabolism_Homo sapiens_hsa01212	0.33521311
88	GABAergic synapse_Homo sapiens_hsa04727	0.32854947
89	Glucagon signaling pathway_Homo sapiens_hsa04922	0.32352965
90	cAMP signaling pathway_Homo sapiens_hsa04024	0.31255380
91	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.30728751
92	Metabolic pathways_Homo sapiens_hsa01100	0.29509051
93	RNA transport_Homo sapiens_hsa03013	0.29263196
94	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.27500839
95	Oocyte meiosis_Homo sapiens_hsa04114	0.26895537
96	p53 signaling pathway_Homo sapiens_hsa04115	0.26750246
97	FoxO signaling pathway_Homo sapiens_hsa04068	0.21612495
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.19249093
99	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.18501143
100	African trypanosomiasis_Homo sapiens_hsa05143	0.17863891

RPL18P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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