ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome reaction (GO:0007340)	5.76648460
2	piRNA metabolic process (GO:0034587)	5.24989744
3	multicellular organism reproduction (GO:0032504)	5.19205242
4	DNA deamination (GO:0045006)	4.95513095
5	sperm motility (GO:0030317)	4.82683266
6	response to pheromone (GO:0019236)	4.65820882
7	ribosomal small subunit assembly (GO:0000028)	4.64324731
8	rRNA modification (GO:0000154)	4.43160015
9	spermatid development (GO:0007286)	4.31941829
10	platelet dense granule organization (GO:0060155)	4.18704532
11	DNA methylation involved in gamete generation (GO:0043046)	4.06048891
12	regulation of acrosome reaction (GO:0060046)	4.00696040
13	GTP biosynthetic process (GO:0006183)	3.95911495
14	base-excision repair, AP site formation (GO:0006285)	3.83498454
15	reproduction (GO:0000003)	3.73895645
16	male meiosis I (GO:0007141)	3.73748078
17	chaperone-mediated protein transport (GO:0072321)	3.73263330
18	centriole replication (GO:0007099)	3.72878725
19	rRNA methylation (GO:0031167)	3.72381107
20	viral transcription (GO:0019083)	3.71046662
21	fusion of sperm to egg plasma membrane (GO:0007342)	3.69799098
22	glycine transport (GO:0015816)	3.59954218
23	DNA packaging (GO:0006323)	3.58756714
24	maturation of SSU-rRNA (GO:0030490)	3.58477238
25	male meiosis (GO:0007140)	3.56815038
26	positive regulation of gastrulation (GO:2000543)	3.51709098
27	kynurenine metabolic process (GO:0070189)	3.51516841
28	translational termination (GO:0006415)	3.51274876
29	sperm-egg recognition (GO:0035036)	3.48076863
30	cellular ketone body metabolic process (GO:0046950)	3.45835582
31	type B pancreatic cell proliferation (GO:0044342)	3.44524895
32	indole-containing compound catabolic process (GO:0042436)	3.42464568
33	indolalkylamine catabolic process (GO:0046218)	3.42464568
34	tryptophan catabolic process (GO:0006569)	3.42464568
35	calcium ion-dependent exocytosis (GO:0017156)	3.40135762
36	centriole assembly (GO:0098534)	3.39542140
37	UTP biosynthetic process (GO:0006228)	3.38920746
38	female mating behavior (GO:0060180)	3.38671231
39	mast cell degranulation (GO:0043303)	3.37834175
40	mast cell activation involved in immune response (GO:0002279)	3.37834175
41	sperm capacitation (GO:0048240)	3.30172360
42	negative regulation of mast cell activation (GO:0033004)	3.30032690
43	outer ear morphogenesis (GO:0042473)	3.23356621
44	meiotic cell cycle (GO:0051321)	3.22750389
45	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.22102371
46	motile cilium assembly (GO:0044458)	3.20508364
47	translational elongation (GO:0006414)	3.18106110
48	positive regulation of T cell apoptotic process (GO:0070234)	3.17089139
49	single fertilization (GO:0007338)	3.16976216
50	ribosomal large subunit biogenesis (GO:0042273)	3.16720891
51	chromosome condensation (GO:0030261)	3.15569705
52	regulation of mitotic spindle checkpoint (GO:1903504)	3.14509559
53	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.14509559
54	UTP metabolic process (GO:0046051)	3.09570575
55	axonemal dynein complex assembly (GO:0070286)	3.09259315
56	ketone body metabolic process (GO:1902224)	3.04802942
57	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.04417394
58	termination of RNA polymerase III transcription (GO:0006386)	3.04417394
59	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.03443096
60	regulation of female gonad development (GO:2000194)	3.02231176
61	binding of sperm to zona pellucida (GO:0007339)	3.01972180
62	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.99618363
63	protein polyglutamylation (GO:0018095)	2.99236962
64	water-soluble vitamin biosynthetic process (GO:0042364)	2.99060860
65	ribosomal small subunit biogenesis (GO:0042274)	2.98180190
66	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.97887239
67	plasma membrane fusion (GO:0045026)	2.92580817
68	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.90008183
69	isotype switching (GO:0045190)	2.90008183
70	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.90008183
71	cotranslational protein targeting to membrane (GO:0006613)	2.89645312
72	spermatogenesis (GO:0007283)	2.88058351
73	male gamete generation (GO:0048232)	2.87636513
74	protein targeting to ER (GO:0045047)	2.87511218
75	positive regulation of respiratory burst (GO:0060267)	2.84728599
76	retinal cone cell development (GO:0046549)	2.81122371
77	cell-cell recognition (GO:0009988)	2.79177851
78	meiosis I (GO:0007127)	2.78974920
79	positive regulation of prostaglandin secretion (GO:0032308)	2.77279038
80	protein localization to endoplasmic reticulum (GO:0070972)	2.77042721
81	tryptophan metabolic process (GO:0006568)	2.76945863
82	fertilization (GO:0009566)	2.74458489
83	regulation of activation of Janus kinase activity (GO:0010533)	2.73530886
84	regulation of retinoic acid receptor signaling pathway (GO:0048385)	2.72327865
85	cellular protein complex disassembly (GO:0043624)	2.71933680
86	purine deoxyribonucleotide catabolic process (GO:0009155)	2.70870578
87	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.69001340
88	negative regulation of T cell differentiation in thymus (GO:0033085)	2.68501292
89	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.67856842
90	DNA integration (GO:0015074)	2.66440134
91	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.65779401
92	gamete generation (GO:0007276)	2.65401669
93	ribonucleoprotein complex biogenesis (GO:0022613)	2.63981912
94	inner mitochondrial membrane organization (GO:0007007)	2.62826235
95	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.62326943
96	microtubule depolymerization (GO:0007019)	2.62120024
97	protein complex biogenesis (GO:0070271)	2.61845344
98	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.61270977
99	NADH dehydrogenase complex assembly (GO:0010257)	2.61270977
100	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.61270977

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.18216140
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.99373575
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.22904891
4	VDR_22108803_ChIP-Seq_LS180_Human	3.21697862
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.12059046
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.75622516
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.64374624
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.62971729
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.45704001
10	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.43444964
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.36087858
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.20675875
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.19075077
14	IRF1_19129219_ChIP-ChIP_H3396_Human	2.16152713
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.07976023
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.07863141
17	NANOG_20526341_ChIP-Seq_ESCs_Human	1.92731809
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.86447827
19	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.83822978
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.69178308
21	ERA_21632823_ChIP-Seq_H3396_Human	1.63470449
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.62624342
23	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.60629049
24	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.57824923
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.57398611
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.55812589
27	TAF2_19829295_ChIP-Seq_ESCs_Human	1.55270336
28	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.54403978
29	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.53740897
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.50731718
31	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.48658065
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.48603650
33	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.47315015
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.46010123
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.45779550
36	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.41151865
37	VDR_23849224_ChIP-Seq_CD4+_Human	1.40866443
38	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.40801096
39	CTCF_20526341_ChIP-Seq_ESCs_Human	1.40463726
40	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.39081662
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.37972456
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37972456
43	RAC3_21632823_ChIP-Seq_H3396_Human	1.33110138
44	GBX2_23144817_ChIP-Seq_PC3_Human	1.31329427
45	P300_27268052_Chip-Seq_Bcells_Human	1.31292176
46	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.30928210
47	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.30595986
48	E2F1_20622854_ChIP-Seq_HELA_Human	1.30358640
49	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.29445310
50	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.27757412
51	ERG_20517297_ChIP-Seq_VCAP_Human	1.27735292
52	BCL6_27268052_Chip-Seq_Bcells_Human	1.27470589
53	NCOR_22424771_ChIP-Seq_293T_Human	1.27427861
54	MYC_19829295_ChIP-Seq_ESCs_Human	1.25951659
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.23655565
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23371825
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23371825
58	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.21390670
59	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.21195206
60	HOXB7_26014856_ChIP-Seq_BT474_Human	1.19912240
61	AR_20517297_ChIP-Seq_VCAP_Human	1.17396541
62	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.16004623
63	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.14816099
64	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14816099
65	EWS_26573619_Chip-Seq_HEK293_Human	1.13532772
66	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12690405
67	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10600142
68	SMRT_27268052_Chip-Seq_Bcells_Human	1.10491453
69	P53_21459846_ChIP-Seq_SAOS-2_Human	1.09965590
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09769268
71	FUS_26573619_Chip-Seq_HEK293_Human	1.09506250
72	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.08715317
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08428301
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08428301
75	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08046543
76	BCOR_27268052_Chip-Seq_Bcells_Human	1.07348493
77	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.07135153
78	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.06799301
79	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.06706910
80	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.06016984
81	BCAT_22108803_ChIP-Seq_LS180_Human	1.05922825
82	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04901983
83	P300_19829295_ChIP-Seq_ESCs_Human	1.04034302
84	RUNX_20019798_ChIP-Seq_JUKART_Human	1.03774791
85	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.03610009
86	RBPJ_21746931_ChIP-Seq_IB4_Human	1.02967039
87	RUNX2_22187159_ChIP-Seq_PCA_Human	1.02436231
88	OCT4_20526341_ChIP-Seq_ESCs_Human	1.00983988
89	GATA3_26560356_Chip-Seq_TH2_Human	0.98290537
90	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97185527
91	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.97034840
92	AR_25329375_ChIP-Seq_VCAP_Human	0.97024076
93	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.95734274
94	RNF2_27304074_Chip-Seq_NSC_Mouse	0.95558972
95	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.93558345
96	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92718308
97	TCF4_22108803_ChIP-Seq_LS180_Human	0.91716236
98	PHF8_20622853_ChIP-Seq_HELA_Human	0.91575182
99	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.91203521
100	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.89898131

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.29402509
2	MP0005410_abnormal_fertilization	5.10719939
3	MP0006292_abnormal_olfactory_placode	3.99304289
4	MP0003718_maternal_effect	3.78077871
5	MP0008877_abnormal_DNA_methylation	3.67599128
6	MP0008875_abnormal_xenobiotic_pharmacok	2.76257347
7	MP0005646_abnormal_pituitary_gland	2.72638486
8	MP0002234_abnormal_pharynx_morphology	2.61174429
9	MP0002138_abnormal_hepatobiliary_system	2.49470572
10	MP0001929_abnormal_gametogenesis	2.10122718
11	MP0002876_abnormal_thyroid_physiology	2.08919940
12	MP0002163_abnormal_gland_morphology	1.97538047
13	MP0002822_catalepsy	1.95650322
14	MP0003693_abnormal_embryo_hatching	1.85850645
15	MP0002160_abnormal_reproductive_system	1.85159249
16	MP0005551_abnormal_eye_electrophysiolog	1.72476694
17	MP0003698_abnormal_male_reproductive	1.71541181
18	MP0005174_abnormal_tail_pigmentation	1.70017610
19	MP0004142_abnormal_muscle_tone	1.69060215
20	MP0008872_abnormal_physiological_respon	1.66290412
21	MP0005377_hearing/vestibular/ear_phenot	1.59650672
22	MP0003878_abnormal_ear_physiology	1.59650672
23	MP0001968_abnormal_touch/_nociception	1.57546258
24	MP0002210_abnormal_sex_determination	1.54527389
25	MP0005379_endocrine/exocrine_gland_phen	1.50660626
26	MP0005389_reproductive_system_phenotype	1.47377039
27	MP0005671_abnormal_response_to	1.46364992
28	MP0000015_abnormal_ear_pigmentation	1.46309742
29	MP0003195_calcinosis	1.40785805
30	MP0000049_abnormal_middle_ear	1.40294368
31	MP0003646_muscle_fatigue	1.38785096
32	MP0010368_abnormal_lymphatic_system	1.38216091
33	MP0005395_other_phenotype	1.33308160
34	MP0005645_abnormal_hypothalamus_physiol	1.33218880
35	MP0005670_abnormal_white_adipose	1.33178565
36	MP0002095_abnormal_skin_pigmentation	1.29454335
37	MP0001905_abnormal_dopamine_level	1.29147604
38	MP0002837_dystrophic_cardiac_calcinosis	1.26358489
39	MP0001188_hyperpigmentation	1.25353969
40	MP0002277_abnormal_respiratory_mucosa	1.25201924
41	MP0002102_abnormal_ear_morphology	1.23811079
42	MP0000653_abnormal_sex_gland	1.21936476
43	MP0002161_abnormal_fertility/fecundity	1.19992130
44	MP0004885_abnormal_endolymph	1.18924474
45	MP0009046_muscle_twitch	1.17475263
46	MP0000685_abnormal_immune_system	1.15286237
47	MP0001293_anophthalmia	1.15205402
48	MP0004782_abnormal_surfactant_physiolog	1.14367132
49	MP0002272_abnormal_nervous_system	1.14164737
50	MP0001348_abnormal_lacrimal_gland	1.13533702
51	MP0008995_early_reproductive_senescence	1.12461789
52	MP0005636_abnormal_mineral_homeostasis	1.10726759
53	MP0008058_abnormal_DNA_repair	1.09967817
54	MP0002736_abnormal_nociception_after	1.06525749
55	MP0001145_abnormal_male_reproductive	1.03975024
56	MP0001919_abnormal_reproductive_system	1.03825237
57	MP0000631_abnormal_neuroendocrine_gland	1.00389366
58	MP0001835_abnormal_antigen_presentation	0.99427930
59	MP0006036_abnormal_mitochondrial_physio	0.99293549
60	MP0005647_abnormal_sex_gland	0.98851981
61	MP0005257_abnormal_intraocular_pressure	0.95816080
62	MP0009745_abnormal_behavioral_response	0.93595479
63	MP0005253_abnormal_eye_physiology	0.93474225
64	MP0002638_abnormal_pupillary_reflex	0.92399467
65	MP0000613_abnormal_salivary_gland	0.92355381
66	MP0000569_abnormal_digit_pigmentation	0.92319580
67	MP0001853_heart_inflammation	0.90827326
68	MP0002735_abnormal_chemical_nociception	0.90270902
69	MP0003283_abnormal_digestive_organ	0.89571673
70	MP0003011_delayed_dark_adaptation	0.87776444
71	MP0002254_reproductive_system_inflammat	0.82732786
72	MP0005167_abnormal_blood-brain_barrier	0.81449600
73	MP0002653_abnormal_ependyma_morphology	0.81120129
74	MP0002693_abnormal_pancreas_physiology	0.80949960
75	MP0004043_abnormal_pH_regulation	0.80423623
76	MP0009764_decreased_sensitivity_to	0.79232758
77	MP0006072_abnormal_retinal_apoptosis	0.78984834
78	MP0005360_urolithiasis	0.78836731
79	MP0006054_spinal_hemorrhage	0.78441238
80	MP0003699_abnormal_female_reproductive	0.77967269
81	MP0009697_abnormal_copulation	0.77756700
82	MP0000427_abnormal_hair_cycle	0.75404967
83	MP0008789_abnormal_olfactory_epithelium	0.71870615
84	MP0003186_abnormal_redox_activity	0.71844643
85	MP0001119_abnormal_female_reproductive	0.71832607
86	MP0010307_abnormal_tumor_latency	0.70690335
87	MP0002733_abnormal_thermal_nociception	0.70246989
88	MP0001501_abnormal_sleep_pattern	0.69903190
89	MP0001800_abnormal_humoral_immune	0.68966331
90	MP0002229_neurodegeneration	0.68534308
91	MP0003119_abnormal_digestive_system	0.67835918
92	MP0001486_abnormal_startle_reflex	0.67646035
93	MP0003786_premature_aging	0.65877985
94	MP0006276_abnormal_autonomic_nervous	0.65737642
95	MP0001986_abnormal_taste_sensitivity	0.65572851
96	MP0001765_abnormal_ion_homeostasis	0.65021713
97	MP0002928_abnormal_bile_duct	0.63574226
98	MP0003137_abnormal_impulse_conducting	0.62956397
99	MP0001963_abnormal_hearing_physiology	0.59801273
100	MP0002148_abnormal_hypersensitivity_rea	0.58753096

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.89048379
2	Colon cancer (HP:0003003)	4.85594944
3	Stomach cancer (HP:0012126)	4.40252285
4	Pancreatic fibrosis (HP:0100732)	3.84902030
5	Increased IgM level (HP:0003496)	3.84701811
6	Bile duct proliferation (HP:0001408)	3.77568563
7	Abnormal biliary tract physiology (HP:0012439)	3.77568563
8	Stomatitis (HP:0010280)	3.58700843
9	Severe visual impairment (HP:0001141)	3.49960053
10	Molar tooth sign on MRI (HP:0002419)	3.42697919
11	Abnormality of midbrain morphology (HP:0002418)	3.42697919
12	Attenuation of retinal blood vessels (HP:0007843)	3.41117083
13	Abnormal rod and cone electroretinograms (HP:0008323)	3.38905456
14	Pancreatic cysts (HP:0001737)	3.38676214
15	Abnormality of abdominal situs (HP:0011620)	3.10258147
16	Abdominal situs inversus (HP:0003363)	3.10258147
17	True hermaphroditism (HP:0010459)	3.09418834
18	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.03275241
19	Pendular nystagmus (HP:0012043)	3.01950726
20	Type 2 muscle fiber atrophy (HP:0003554)	2.89065933
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.88315314
22	Sclerocornea (HP:0000647)	2.81943276
23	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.78897178
24	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.75722593
25	Absent/shortened dynein arms (HP:0200106)	2.73546821
26	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.73546821
27	Supernumerary spleens (HP:0009799)	2.73512713
28	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.53936161
29	Muscle fiber atrophy (HP:0100295)	2.49918985
30	Abnormality of the renal cortex (HP:0011035)	2.44338258
31	Autoimmune thrombocytopenia (HP:0001973)	2.43643777
32	Cystic liver disease (HP:0006706)	2.41986371
33	Polyuria (HP:0000103)	2.40801256
34	Decreased central vision (HP:0007663)	2.39684442
35	Polydipsia (HP:0001959)	2.39144264
36	Abnormal drinking behavior (HP:0030082)	2.39144264
37	Abnormal respiratory motile cilium physiology (HP:0012261)	2.36505793
38	Impulsivity (HP:0100710)	2.36364359
39	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.36316115
40	Abolished electroretinogram (ERG) (HP:0000550)	2.36280906
41	Chronic hepatic failure (HP:0100626)	2.34602292
42	Acute necrotizing encephalopathy (HP:0006965)	2.34466195
43	Nephronophthisis (HP:0000090)	2.32790583
44	Type I transferrin isoform profile (HP:0003642)	2.30276162
45	Asplenia (HP:0001746)	2.29307700
46	Abnormality of the renal medulla (HP:0100957)	2.29075447
47	Acute encephalopathy (HP:0006846)	2.22291926
48	IgG deficiency (HP:0004315)	2.21862847
49	Abnormal ciliary motility (HP:0012262)	2.19654028
50	Abnormal urine output (HP:0012590)	2.19498035
51	Optic nerve coloboma (HP:0000588)	2.18151285
52	Abnormal spermatogenesis (HP:0008669)	2.16065113
53	Anencephaly (HP:0002323)	2.14355924
54	3-Methylglutaconic aciduria (HP:0003535)	2.02636308
55	Abnormality of B cell number (HP:0010975)	2.01514084
56	Progressive macrocephaly (HP:0004481)	2.00957950
57	Autoimmune hemolytic anemia (HP:0001890)	1.99148334
58	Cone-rod dystrophy (HP:0000548)	1.99140532
59	Abnormality of macular pigmentation (HP:0008002)	1.98460079
60	Abnormality of T cell physiology (HP:0011840)	1.97790668
61	Abnormal mitochondria in muscle tissue (HP:0008316)	1.97488276
62	Occipital encephalocele (HP:0002085)	1.95675261
63	Methylmalonic acidemia (HP:0002912)	1.95147809
64	Increased corneal curvature (HP:0100692)	1.94724247
65	Keratoconus (HP:0000563)	1.94724247
66	Metabolic alkalosis (HP:0200114)	1.94158696
67	Hypochromic anemia (HP:0001931)	1.93841859
68	Abnormality of renal excretion (HP:0011036)	1.91507474
69	Oral leukoplakia (HP:0002745)	1.91174839
70	Optic nerve hypoplasia (HP:0000609)	1.89491435
71	Type I diabetes mellitus (HP:0100651)	1.88519168
72	Hyperglycinemia (HP:0002154)	1.87221503
73	Congenital, generalized hypertrichosis (HP:0004540)	1.86430183
74	Septo-optic dysplasia (HP:0100842)	1.86001657
75	Medial flaring of the eyebrow (HP:0010747)	1.84866935
76	Tubular atrophy (HP:0000092)	1.84697532
77	Bony spicule pigmentary retinopathy (HP:0007737)	1.84413016
78	Anterior segment dysgenesis (HP:0007700)	1.84033184
79	Limb dystonia (HP:0002451)	1.83748413
80	Maternal diabetes (HP:0009800)	1.83060424
81	Aplastic anemia (HP:0001915)	1.81484141
82	Postaxial foot polydactyly (HP:0001830)	1.80891603
83	Opisthotonus (HP:0002179)	1.79592374
84	Abnormality of the axillary hair (HP:0100134)	1.79402124
85	Abnormality of secondary sexual hair (HP:0009888)	1.79402124
86	Macular degeneration (HP:0000608)	1.79080091
87	Male pseudohermaphroditism (HP:0000037)	1.79018225
88	Prostate neoplasm (HP:0100787)	1.78264846
89	Mitochondrial inheritance (HP:0001427)	1.77091116
90	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.76953192
91	Type II lissencephaly (HP:0007260)	1.76886922
92	Azoospermia (HP:0000027)	1.74835302
93	Reticulocytopenia (HP:0001896)	1.73526965
94	Hypokalemic alkalosis (HP:0001949)	1.73148869
95	Hypochromic microcytic anemia (HP:0004840)	1.72417451
96	Abnormal respiratory epithelium morphology (HP:0012253)	1.70759851
97	Abnormal respiratory motile cilium morphology (HP:0005938)	1.70759851
98	Abnormal protein glycosylation (HP:0012346)	1.70285544
99	Abnormal glycosylation (HP:0012345)	1.70285544
100	Abnormal protein N-linked glycosylation (HP:0012347)	1.70285544

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ARAF	3.74474174
2	CAMKK2	3.50276672
3	TIE1	3.26971700
4	VRK2	3.23965308
5	MAP4K2	3.16893680
6	PLK4	3.03107236
7	PINK1	2.67610751
8	WNK4	2.55459058
9	NUAK1	2.49921674
10	PIM2	2.32133224
11	DAPK2	2.19970981
12	ADRBK2	2.07919433
13	GRK1	2.06035830
14	ZAK	1.99527615
15	BRAF	1.95700888
16	TAF1	1.94466255
17	PASK	1.86682323
18	CAMKK1	1.79637498
19	EIF2AK1	1.75046987
20	INSRR	1.71014548
21	NME1	1.69887272
22	PLK2	1.67906827
23	NME2	1.65206121
24	WNK1	1.62290022
25	VRK1	1.47664472
26	CDK19	1.46286881
27	FRK	1.38190285
28	MAPKAPK5	1.32719177
29	STK16	1.31835385
30	TEC	1.30424791
31	STK39	1.28111434
32	TLK1	1.25689229
33	TAOK3	1.22391128
34	CSNK1G3	1.21328226
35	OXSR1	1.14604354
36	NTRK3	1.13305714
37	PTK2B	1.12717725
38	CAMK1	1.10402957
39	TYRO3	1.08488930
40	NEK6	1.06426874
41	CSNK1G1	1.05260859
42	BMPR1B	1.01808746
43	CSNK1G2	0.97161967
44	RAF1	0.96459264
45	KDR	0.96267772
46	TXK	0.87607429
47	MAP3K11	0.86982948
48	PRKCI	0.86424633
49	ITK	0.85131440
50	WNK3	0.81999017
51	CDK7	0.81307085
52	CSNK1A1L	0.80072635
53	AURKA	0.77959161
54	GRK6	0.75559756
55	NEK1	0.71296710
56	GRK5	0.70476604
57	KIT	0.70382098
58	PRKD3	0.70073100
59	RPS6KA5	0.69749368
60	CAMK1G	0.69129324
61	TESK1	0.64184451
62	CAMK1D	0.62004789
63	IKBKB	0.59082090
64	PRKCQ	0.58717474
65	BCKDK	0.53919602
66	TAOK2	0.53389126
67	PIM1	0.51968419
68	CHEK2	0.51829675
69	PRKG1	0.49649534
70	CAMK4	0.47425867
71	ABL2	0.47142545
72	MAP2K6	0.46962714
73	EIF2AK3	0.46157704
74	PRKAA2	0.43263896
75	PAK1	0.41667064
76	PHKG2	0.40834654
77	PHKG1	0.40834654
78	CSNK1D	0.40094459
79	BRSK1	0.38803036
80	SYK	0.38726737
81	TNK2	0.38407277
82	IKBKE	0.38025149
83	MAPK15	0.37876759
84	TNIK	0.37704635
85	ADRBK1	0.37263134
86	PRKACA	0.35507614
87	AKT2	0.34222425
88	MUSK	0.34189538
89	PDK1	0.32686238
90	STK38	0.32208712
91	BRSK2	0.31666314
92	PRKCG	0.31583388
93	TTK	0.30996472
94	AURKB	0.30367697
95	PLK3	0.30162389
96	PKN1	0.28887575
97	DYRK2	0.28396012
98	EIF2AK2	0.28374546
99	LRRK2	0.28028320
100	CAMK2A	0.27664760

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.96569389
2	Caffeine metabolism_Homo sapiens_hsa00232	3.34284956
3	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.21263508
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.96774696
5	RNA polymerase_Homo sapiens_hsa03020	2.75023859
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.57579913
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.43702953
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.23106340
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.15374383
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.10051594
11	Parkinsons disease_Homo sapiens_hsa05012	2.02782025
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.92544412
13	Homologous recombination_Homo sapiens_hsa03440	1.86347895
14	RNA degradation_Homo sapiens_hsa03018	1.86148396
15	Base excision repair_Homo sapiens_hsa03410	1.81211965
16	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.81023228
17	Proteasome_Homo sapiens_hsa03050	1.76038498
18	Huntingtons disease_Homo sapiens_hsa05016	1.68359523
19	Primary immunodeficiency_Homo sapiens_hsa05340	1.62895354
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.61168459
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.58399571
22	Basal transcription factors_Homo sapiens_hsa03022	1.54067638
23	Butanoate metabolism_Homo sapiens_hsa00650	1.52002379
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.46954914
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.45604539
26	RNA transport_Homo sapiens_hsa03013	1.42289588
27	Alzheimers disease_Homo sapiens_hsa05010	1.41455914
28	Pyrimidine metabolism_Homo sapiens_hsa00240	1.39860817
29	Allograft rejection_Homo sapiens_hsa05330	1.39561153
30	One carbon pool by folate_Homo sapiens_hsa00670	1.38780672
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.37822333
32	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.37782662
33	Regulation of autophagy_Homo sapiens_hsa04140	1.36635783
34	Mismatch repair_Homo sapiens_hsa03430	1.35359002
35	Phototransduction_Homo sapiens_hsa04744	1.33179159
36	ABC transporters_Homo sapiens_hsa02010	1.25444548
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.22565805
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.19318752
39	Purine metabolism_Homo sapiens_hsa00230	1.18347892
40	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.10989599
41	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.10180059
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.09331274
43	Fanconi anemia pathway_Homo sapiens_hsa03460	1.07614528
44	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.07224881
45	Protein export_Homo sapiens_hsa03060	1.04533965
46	Type I diabetes mellitus_Homo sapiens_hsa04940	1.03404833
47	Propanoate metabolism_Homo sapiens_hsa00640	1.03239004
48	Cardiac muscle contraction_Homo sapiens_hsa04260	1.03036572
49	Olfactory transduction_Homo sapiens_hsa04740	1.02128660
50	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.00215852
51	Fatty acid degradation_Homo sapiens_hsa00071	0.98794008
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95429362
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.94762931
54	Retinol metabolism_Homo sapiens_hsa00830	0.93363555
55	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.86239193
56	Asthma_Homo sapiens_hsa05310	0.85328324
57	Graft-versus-host disease_Homo sapiens_hsa05332	0.83954070
58	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.83738490
59	Antigen processing and presentation_Homo sapiens_hsa04612	0.82350017
60	Peroxisome_Homo sapiens_hsa04146	0.79740142
61	DNA replication_Homo sapiens_hsa03030	0.79433055
62	Arginine and proline metabolism_Homo sapiens_hsa00330	0.78033229
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77523117
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74239521
65	p53 signaling pathway_Homo sapiens_hsa04115	0.71977778
66	Taste transduction_Homo sapiens_hsa04742	0.67511761
67	Metabolic pathways_Homo sapiens_hsa01100	0.65753818
68	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.64556617
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.63637583
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.62828577
71	Sulfur relay system_Homo sapiens_hsa04122	0.61901092
72	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.61755829
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.61658712
74	Salivary secretion_Homo sapiens_hsa04970	0.61633901
75	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.61240889
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61087525
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60489730
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.60434293
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58626417
80	Rheumatoid arthritis_Homo sapiens_hsa05323	0.56321728
81	Pyruvate metabolism_Homo sapiens_hsa00620	0.54884973
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.54096015
83	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.53140123
84	Fatty acid metabolism_Homo sapiens_hsa01212	0.48743787
85	African trypanosomiasis_Homo sapiens_hsa05143	0.42086152
86	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41657875
87	Insulin secretion_Homo sapiens_hsa04911	0.38295088
88	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.36888890
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.36157034
90	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.35030050
91	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.33406431
92	Folate biosynthesis_Homo sapiens_hsa00790	0.32845902
93	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.32619868
94	Calcium signaling pathway_Homo sapiens_hsa04020	0.32381503
95	Serotonergic synapse_Homo sapiens_hsa04726	0.32111047
96	Fatty acid elongation_Homo sapiens_hsa00062	0.29414703
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.28550984
98	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.27573510
99	Tyrosine metabolism_Homo sapiens_hsa00350	0.24073030
100	VEGF signaling pathway_Homo sapiens_hsa04370	0.24007864

RPL18P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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