ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to gravity (GO:0009629)	6.77337655
2	maturation of SSU-rRNA (GO:0030490)	5.45731216
3	viral transcription (GO:0019083)	5.43811684
4	ATP synthesis coupled proton transport (GO:0015986)	5.24781524
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.24781524
6	ribosomal small subunit assembly (GO:0000028)	5.20076348
7	translational termination (GO:0006415)	5.14131719
8	translational elongation (GO:0006414)	4.97050928
9	DNA deamination (GO:0045006)	4.86184711
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.81517535
11	ribosomal small subunit biogenesis (GO:0042274)	4.62731847
12	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.58026913
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.58026913
14	striated muscle atrophy (GO:0014891)	4.55300743
15	skeletal muscle adaptation (GO:0043501)	4.51918328
16	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.46183204
17	muscle atrophy (GO:0014889)	4.38602535
18	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.38029855
19	protein targeting to ER (GO:0045047)	4.36868142
20	cotranslational protein targeting to membrane (GO:0006613)	4.35779405
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.26858573
22	cytidine deamination (GO:0009972)	4.19009673
23	cytidine metabolic process (GO:0046087)	4.19009673
24	cytidine catabolic process (GO:0006216)	4.19009673
25	protein localization to endoplasmic reticulum (GO:0070972)	4.15889700
26	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.13066463
27	respiratory electron transport chain (GO:0022904)	4.02790205
28	electron transport chain (GO:0022900)	4.01840034
29	protein-cofactor linkage (GO:0018065)	4.01445418
30	chaperone-mediated protein transport (GO:0072321)	4.00195866
31	regulation of skeletal muscle contraction (GO:0014819)	3.97186459
32	cellular protein complex disassembly (GO:0043624)	3.95668727
33	negative regulation of muscle hypertrophy (GO:0014741)	3.90620778
34	viral life cycle (GO:0019058)	3.90021451
35	protein neddylation (GO:0045116)	3.86799962
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.82090245
37	NADH dehydrogenase complex assembly (GO:0010257)	3.82090245
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.82090245
39	protein complex biogenesis (GO:0070271)	3.77349777
40	proteasome assembly (GO:0043248)	3.72645492
41	purine nucleotide salvage (GO:0032261)	3.69708593
42	muscle filament sliding (GO:0030049)	3.67487515
43	actin-myosin filament sliding (GO:0033275)	3.67487515
44	skeletal muscle tissue regeneration (GO:0043403)	3.63399768
45	translation (GO:0006412)	3.62572261
46	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.60124716
47	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.53779603
48	homocysteine metabolic process (GO:0050667)	3.53721207
49	ribonucleoprotein complex biogenesis (GO:0022613)	3.52628658
50	translational initiation (GO:0006413)	3.51616323
51	platelet dense granule organization (GO:0060155)	3.44426652
52	cellular component biogenesis (GO:0044085)	3.38898114
53	ribosome biogenesis (GO:0042254)	3.38020827
54	mitochondrial respiratory chain complex assembly (GO:0033108)	3.34341821
55	protein polyglutamylation (GO:0018095)	3.30293085
56	protein complex disassembly (GO:0043241)	3.28481062
57	rRNA processing (GO:0006364)	3.26273316
58	response to testosterone (GO:0033574)	3.21785953
59	rRNA metabolic process (GO:0016072)	3.19174327
60	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.14656518
61	macromolecular complex disassembly (GO:0032984)	3.13514533
62	ribosomal large subunit biogenesis (GO:0042273)	3.12190327
63	termination of RNA polymerase III transcription (GO:0006386)	3.11252959
64	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.11252959
65	ATP biosynthetic process (GO:0006754)	3.08216597
66	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.07515121
67	sequestering of actin monomers (GO:0042989)	3.07477723
68	GTP biosynthetic process (GO:0006183)	3.05293781
69	water-soluble vitamin biosynthetic process (GO:0042364)	3.05287864
70	response to muscle activity (GO:0014850)	2.97931766
71	ubiquinone biosynthetic process (GO:0006744)	2.96840447
72	protein K6-linked ubiquitination (GO:0085020)	2.94876735
73	pseudouridine synthesis (GO:0001522)	2.92206038
74	negative T cell selection (GO:0043383)	2.91358393
75	regulation of cellular amino acid metabolic process (GO:0006521)	2.90827530
76	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.88949596
77	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.88684826
78	cytolysis (GO:0019835)	2.88257598
79	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.88021729
80	protein targeting to membrane (GO:0006612)	2.81864469
81	protein targeting to mitochondrion (GO:0006626)	2.81611846
82	hydrogen ion transmembrane transport (GO:1902600)	2.80449448
83	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.77182843
84	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.75483400
85	actin-mediated cell contraction (GO:0070252)	2.73284897
86	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.73282831
87	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.71587652
88	negative regulation of skeletal muscle tissue development (GO:0048642)	2.71210009
89	guanosine-containing compound biosynthetic process (GO:1901070)	2.70502948
90	protein deneddylation (GO:0000338)	2.69568072
91	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.69408115
92	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.68805013
93	male meiosis I (GO:0007141)	2.68650871
94	mannosylation (GO:0097502)	2.68135894
95	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.67553453
96	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.67256448
97	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.66127311
98	cullin deneddylation (GO:0010388)	2.64943665
99	glyoxylate metabolic process (GO:0046487)	2.64886575
100	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.64577921

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.23626793
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.89291969
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.01015944
4	VDR_22108803_ChIP-Seq_LS180_Human	3.73796856
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.67206281
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.45740922
7	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.22972888
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.19312830
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.10959812
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.94768205
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.82378384
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.55569960
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.47001032
14	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.36674611
15	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.13292630
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.09343424
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.06312801
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.01980478
19	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.93064005
20	FOXP3_21729870_ChIP-Seq_TREG_Human	1.91582585
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.84689125
22	ZNF274_21170338_ChIP-Seq_K562_Hela	1.79043405
23	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.66765758
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.65650821
25	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.64327938
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.63055744
27	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.62098451
28	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.58315586
29	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.56847493
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55387398
31	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.55229381
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.55089819
33	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.54412260
34	XRN2_22483619_ChIP-Seq_HELA_Human	1.51673225
35	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.49845144
36	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.49333154
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.44327447
38	GABP_19822575_ChIP-Seq_HepG2_Human	1.41338058
39	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.39400522
40	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.37787607
41	TTF2_22483619_ChIP-Seq_HELA_Human	1.36500800
42	BCL6_27268052_Chip-Seq_Bcells_Human	1.34321161
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.33768089
44	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.33208980
45	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.32600889
46	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.31766286
47	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.31325219
48	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.28974458
49	ERA_21632823_ChIP-Seq_H3396_Human	1.28854982
50	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.26119196
51	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.24823284
52	EZH2_22144423_ChIP-Seq_EOC_Human	1.24353839
53	E2F1_20622854_ChIP-Seq_HELA_Human	1.22302810
54	ELK1_19687146_ChIP-ChIP_HELA_Human	1.21810422
55	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.21208209
56	TAF2_19829295_ChIP-Seq_ESCs_Human	1.20550062
57	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.20116235
58	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.18741969
59	CTCF_20526341_ChIP-Seq_ESCs_Human	1.16957751
60	AR_20517297_ChIP-Seq_VCAP_Human	1.15760385
61	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.15674014
62	NANOG_20526341_ChIP-Seq_ESCs_Human	1.15386413
63	NCOR_22424771_ChIP-Seq_293T_Human	1.14097876
64	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.14046516
65	STAT1_20625510_ChIP-Seq_HELA_Human	1.12784256
66	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.09516013
67	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.09493102
68	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.09174584
69	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.06908531
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05441272
71	MYC_19829295_ChIP-Seq_ESCs_Human	1.03956142
72	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.03095718
73	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02888666
74	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02366874
75	DCP1A_22483619_ChIP-Seq_HELA_Human	1.02130453
76	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.02046027
77	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.01438344
78	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.01387844
79	P53_21459846_ChIP-Seq_SAOS-2_Human	1.00531088
80	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.98826921
81	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.98502860
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97952138
83	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.97528947
84	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.96507694
85	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.95547088
86	BCOR_27268052_Chip-Seq_Bcells_Human	0.94735191
87	KDM5A_27292631_Chip-Seq_BREAST_Human	0.93255148
88	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.92502290
89	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.92351528
90	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.91835883
91	P68_20966046_ChIP-Seq_HELA_Human	0.90027505
92	SA1_27219007_Chip-Seq_Bcells_Human	0.89823748
93	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.89489991
94	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.87584289
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.86398737
96	ZNF263_19887448_ChIP-Seq_K562_Human	0.85498605
97	P300_27268052_Chip-Seq_Bcells_Human	0.84542020
98	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.84322806
99	MAF_26560356_Chip-Seq_TH2_Human	0.84294789
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.83797873

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	4.29614242
2	MP0004145_abnormal_muscle_electrophysio	3.19562998
3	MP0003646_muscle_fatigue	3.01591481
4	MP0005671_abnormal_response_to	2.74962799
5	MP0000372_irregular_coat_pigmentation	2.60747591
6	MP0005646_abnormal_pituitary_gland	2.58068486
7	MP0009379_abnormal_foot_pigmentation	2.39578347
8	MP0003878_abnormal_ear_physiology	2.36024756
9	MP0005377_hearing/vestibular/ear_phenot	2.36024756
10	MP0002653_abnormal_ependyma_morphology	2.32229281
11	MP0002736_abnormal_nociception_after	2.23360713
12	MP0006292_abnormal_olfactory_placode	2.19543184
13	MP0002102_abnormal_ear_morphology	2.17450425
14	MP0005083_abnormal_biliary_tract	2.15553367
15	MP0002163_abnormal_gland_morphology	2.12364132
16	MP0002837_dystrophic_cardiac_calcinosis	2.10248113
17	MP0003806_abnormal_nucleotide_metabolis	1.99385553
18	MP0002095_abnormal_skin_pigmentation	1.98825418
19	MP0002138_abnormal_hepatobiliary_system	1.95797816
20	MP0000749_muscle_degeneration	1.92341942
21	MP0004147_increased_porphyrin_level	1.92210145
22	MP0002160_abnormal_reproductive_system	1.91625361
23	MP0001968_abnormal_touch/_nociception	1.85854570
24	MP0004885_abnormal_endolymph	1.83523949
25	MP0002876_abnormal_thyroid_physiology	1.76750872
26	MP0005645_abnormal_hypothalamus_physiol	1.68702935
27	MP0008872_abnormal_physiological_respon	1.65059687
28	MP0002277_abnormal_respiratory_mucosa	1.47837007
29	MP0001501_abnormal_sleep_pattern	1.46182986
30	MP0005085_abnormal_gallbladder_physiolo	1.45019805
31	MP0000747_muscle_weakness	1.44491093
32	MP0003786_premature_aging	1.42912356
33	MP0001905_abnormal_dopamine_level	1.37652521
34	MP0008789_abnormal_olfactory_epithelium	1.36173995
35	MP0005389_reproductive_system_phenotype	1.35784052
36	MP0008875_abnormal_xenobiotic_pharmacok	1.35781535
37	MP0000685_abnormal_immune_system	1.34717027
38	MP0004036_abnormal_muscle_relaxation	1.30505557
39	MP0002269_muscular_atrophy	1.29872222
40	MP0006072_abnormal_retinal_apoptosis	1.29661152
41	MP0003186_abnormal_redox_activity	1.25067530
42	MP0009785_altered_susceptibility_to	1.23363589
43	MP0005670_abnormal_white_adipose	1.23314893
44	MP0005379_endocrine/exocrine_gland_phen	1.21823605
45	MP0004142_abnormal_muscle_tone	1.20312335
46	MP0006036_abnormal_mitochondrial_physio	1.19581747
47	MP0001835_abnormal_antigen_presentation	1.17416510
48	MP0005636_abnormal_mineral_homeostasis	1.17094375
49	MP0005332_abnormal_amino_acid	1.15422031
50	MP0004043_abnormal_pH_regulation	1.15000459
51	MP0009333_abnormal_splenocyte_physiolog	1.14342443
52	MP0000049_abnormal_middle_ear	1.11745635
53	MP0005365_abnormal_bile_salt	1.10110447
54	MP0003959_abnormal_lean_body	1.09665176
55	MP0003866_abnormal_defecation	1.08346970
56	MP0005551_abnormal_eye_electrophysiolog	1.08244093
57	MP0001764_abnormal_homeostasis	1.06380550
58	MP0008877_abnormal_DNA_methylation	1.05984647
59	MP0005084_abnormal_gallbladder_morpholo	1.05752747
60	MP0002108_abnormal_muscle_morphology	1.01704595
61	MP0004019_abnormal_vitamin_homeostasis	1.00430622
62	MP0000759_abnormal_skeletal_muscle	0.99365470
63	MP0000631_abnormal_neuroendocrine_gland	0.99136673
64	MP0002089_abnormal_postnatal_growth/wei	0.98438615
65	MP0001800_abnormal_humoral_immune	0.95329559
66	MP0002210_abnormal_sex_determination	0.94487929
67	MP0002723_abnormal_immune_serum	0.91042168
68	MP0006276_abnormal_autonomic_nervous	0.90969113
69	MP0003638_abnormal_response/metabolism_	0.90144233
70	MP0001919_abnormal_reproductive_system	0.89295152
71	MP0004130_abnormal_muscle_cell	0.87998532
72	MP0003936_abnormal_reproductive_system	0.87072467
73	MP0001661_extended_life_span	0.86221680
74	MP0001502_abnormal_circadian_rhythm	0.85319589
75	MP0003763_abnormal_thymus_physiology	0.84945708
76	MP0003195_calcinosis	0.82245220
77	MP0008995_early_reproductive_senescence	0.81858245
78	MP0009250_abnormal_appendicular_skeleto	0.80498120
79	MP0001819_abnormal_immune_cell	0.78739814
80	MP0002420_abnormal_adaptive_immunity	0.77849840
81	MP0002106_abnormal_muscle_physiology	0.77431429
82	MP0005620_abnormal_muscle_contractility	0.76012104
83	MP0001765_abnormal_ion_homeostasis	0.75825699
84	MP0003252_abnormal_bile_duct	0.75660408
85	MP0002733_abnormal_thermal_nociception	0.74852763
86	MP0009643_abnormal_urine_homeostasis	0.74432694
87	MP0009745_abnormal_behavioral_response	0.73893634
88	MP0001119_abnormal_female_reproductive	0.73629025
89	MP0005075_abnormal_melanosome_morpholog	0.72724096
90	MP0002148_abnormal_hypersensitivity_rea	0.72341644
91	MP0003183_abnormal_peptide_metabolism	0.72028644
92	MP0000703_abnormal_thymus_morphology	0.69698015
93	MP0001790_abnormal_immune_system	0.68193602
94	MP0005387_immune_system_phenotype	0.68193602
95	MP0002638_abnormal_pupillary_reflex	0.68120847
96	MP0000678_abnormal_parathyroid_gland	0.67852840
97	MP0003937_abnormal_limbs/digits/tail_de	0.66983618
98	MP0003938_abnormal_ear_development	0.66898884
99	MP0000230_abnormal_systemic_arterial	0.66337580
100	MP0000427_abnormal_hair_cycle	0.65402185

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.27153018
2	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.11843774
3	Abnormality of alanine metabolism (HP:0010916)	4.11843774
4	Hyperalaninemia (HP:0003348)	4.11843774
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.98158806
6	Abnormality of cells of the erythroid lineage (HP:0012130)	3.97070944
7	Abnormal number of erythroid precursors (HP:0012131)	3.94997903
8	Aplastic anemia (HP:0001915)	3.89617619
9	Palpebral edema (HP:0100540)	3.85436286
10	3-Methylglutaconic aciduria (HP:0003535)	3.77917462
11	Acute encephalopathy (HP:0006846)	3.76708084
12	Mitochondrial inheritance (HP:0001427)	3.48938452
13	Progressive macrocephaly (HP:0004481)	3.34809639
14	Elevated erythrocyte sedimentation rate (HP:0003565)	3.21735718
15	Reticulocytopenia (HP:0001896)	3.21044043
16	Generalized aminoaciduria (HP:0002909)	3.06382670
17	Absent phalangeal crease (HP:0006109)	3.06002992
18	Increased CSF lactate (HP:0002490)	3.01266482
19	Increased IgM level (HP:0003496)	2.91081621
20	IgG deficiency (HP:0004315)	2.85586073
21	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.85571655
22	Congenital stationary night blindness (HP:0007642)	2.84843062
23	Renal cortical cysts (HP:0000803)	2.72638343
24	Cerebral edema (HP:0002181)	2.70864129
25	Abnormality of the renal cortex (HP:0011035)	2.68415728
26	Hepatic necrosis (HP:0002605)	2.68219124
27	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.67426130
28	Nemaline bodies (HP:0003798)	2.66370508
29	Type II lissencephaly (HP:0007260)	2.64633334
30	Hepatocellular necrosis (HP:0001404)	2.59532634
31	Abnormal drinking behavior (HP:0030082)	2.58500916
32	Polydipsia (HP:0001959)	2.58500916
33	Distal arthrogryposis (HP:0005684)	2.58332125
34	Macrocytic anemia (HP:0001972)	2.54939106
35	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.49212469
36	Pigmentary retinal degeneration (HP:0001146)	2.48405241
37	Abnormal finger flexion creases (HP:0006143)	2.46766219
38	Methylmalonic acidemia (HP:0002912)	2.45601925
39	Increased serum lactate (HP:0002151)	2.44992177
40	Lactic acidosis (HP:0003128)	2.43734741
41	Pallor (HP:0000980)	2.41855649
42	Pancreatic cysts (HP:0001737)	2.37669702
43	Optic disc pallor (HP:0000543)	2.35982190
44	Pancytopenia (HP:0001876)	2.34145674
45	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.30401419
46	Hypoplasia of the radius (HP:0002984)	2.29829559
47	Hypomagnesemia (HP:0002917)	2.21733707
48	Fibular aplasia (HP:0002990)	2.20482735
49	Deformed tarsal bones (HP:0008119)	2.20437769
50	Exercise intolerance (HP:0003546)	2.20433290
51	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.20182753
52	Methylmalonic aciduria (HP:0012120)	2.19376798
53	Renal Fanconi syndrome (HP:0001994)	2.18416517
54	Pancreatic fibrosis (HP:0100732)	2.18242482
55	Abnormality of midbrain morphology (HP:0002418)	2.18131504
56	Molar tooth sign on MRI (HP:0002419)	2.18131504
57	Tetany (HP:0001281)	2.16430528
58	Abnormality of the renal collecting system (HP:0004742)	2.15278907
59	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.14494736
60	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.14494736
61	Polyuria (HP:0000103)	2.12071363
62	Abnormality of magnesium homeostasis (HP:0004921)	2.09916920
63	Reduced antithrombin III activity (HP:0001976)	2.08240784
64	Mask-like facies (HP:0000298)	2.07746124
65	Stenosis of the external auditory canal (HP:0000402)	2.07049451
66	Ulnar deviation of the wrist (HP:0003049)	2.03598847
67	Muscle fiber inclusion bodies (HP:0100299)	2.02433421
68	Periorbital edema (HP:0100539)	2.01528062
69	Myopathic facies (HP:0002058)	2.01218588
70	Lethargy (HP:0001254)	2.00648278
71	Poor speech (HP:0002465)	1.98866038
72	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	1.98745014
73	Round ear (HP:0100830)	1.97238522
74	Stomach cancer (HP:0012126)	1.96760367
75	Absent thumb (HP:0009777)	1.96378935
76	Attenuation of retinal blood vessels (HP:0007843)	1.95323395
77	Oligodactyly (hands) (HP:0001180)	1.95086329
78	Abnormality of serum amino acid levels (HP:0003112)	1.94196102
79	Respiratory failure (HP:0002878)	1.94189278
80	Facial edema (HP:0000282)	1.92962863
81	Constricted visual fields (HP:0001133)	1.92534877
82	Cleft eyelid (HP:0000625)	1.91773923
83	Hyperglycinemia (HP:0002154)	1.90739610
84	Delayed CNS myelination (HP:0002188)	1.89757776
85	Metabolic acidosis (HP:0001942)	1.89462917
86	Hyperuricemia (HP:0002149)	1.89262096
87	Increased purine levels (HP:0004368)	1.89262096
88	Increased intramyocellular lipid droplets (HP:0012240)	1.88953176
89	Pendular nystagmus (HP:0012043)	1.88933397
90	Colon cancer (HP:0003003)	1.87415379
91	Abnormal rod and cone electroretinograms (HP:0008323)	1.86754099
92	True hermaphroditism (HP:0010459)	1.86511191
93	Dicarboxylic aciduria (HP:0003215)	1.86155803
94	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.86155803
95	Abnormal urine output (HP:0012590)	1.84160757
96	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.83041580
97	Calcaneovalgus deformity (HP:0001848)	1.82958645
98	Stomatitis (HP:0010280)	1.82241097
99	Anencephaly (HP:0002323)	1.80101114
100	Oligodactyly (HP:0012165)	1.79799191

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	4.37802056
2	TAOK3	3.51274352
3	VRK2	3.29304698
4	TESK1	2.98434224
5	WNK4	2.85768752
6	TLK1	2.79448067
7	KDR	2.76222967
8	MAP4K1	2.44320656
9	MAP3K11	2.39119152
10	TXK	2.33998505
11	PHKG1	2.28225744
12	PHKG2	2.28225744
13	MAPKAPK3	2.23598647
14	LIMK1	2.11101670
15	TIE1	2.05267821
16	BCKDK	2.00423884
17	NME2	1.94001713
18	ZAK	1.93295040
19	MAP3K12	1.87707956
20	CAMKK2	1.84890367
21	PINK1	1.81289629
22	OBSCN	1.77457486
23	ADRBK2	1.70741512
24	STK16	1.65508720
25	SCYL2	1.44880573
26	NUAK1	1.40283900
27	GRK1	1.39822304
28	CAMKK1	1.37816865
29	MUSK	1.35096402
30	PASK	1.32374014
31	PDK2	1.30898826
32	TAOK2	1.27603590
33	DAPK1	1.21213294
34	VRK1	1.17901369
35	CHEK2	1.16548452
36	STK39	1.12382093
37	JAK3	1.11702361
38	ITK	0.97798612
39	ILK	0.97086436
40	NME1	0.88500486
41	AURKA	0.87061521
42	PRKCQ	0.86686371
43	TEC	0.83893517
44	MAP4K2	0.78651518
45	OXSR1	0.77649606
46	IKBKB	0.76328576
47	BUB1	0.75312391
48	CDK19	0.73118765
49	ABL2	0.70323427
50	MAP3K3	0.69946274
51	DYRK2	0.69939920
52	LMTK2	0.69598054
53	GRK6	0.68060598
54	MAP2K2	0.67839895
55	MST4	0.67529305
56	ADRBK1	0.67407963
57	PIM2	0.65904941
58	CAMK1	0.65186782
59	CCNB1	0.65093963
60	PIK3CA	0.64661871
61	NTRK2	0.64413627
62	IKBKE	0.60449330
63	RPS6KA5	0.59682094
64	PLK4	0.58961070
65	PIM1	0.58033116
66	MARK3	0.55974506
67	CSF1R	0.55340601
68	SYK	0.53051427
69	PRKCI	0.53048192
70	CSNK1G3	0.51974591
71	MAP2K3	0.51046966
72	CSNK2A1	0.50561794
73	FES	0.49986919
74	INSRR	0.48620618
75	BTK	0.45007093
76	CAMK2G	0.44626195
77	MATK	0.44014325
78	CSNK1G1	0.43825813
79	LRRK2	0.42113561
80	MYLK	0.42012494
81	BMPR1B	0.41658108
82	EIF2AK2	0.41541112
83	DAPK2	0.41350396
84	NTRK1	0.41226436
85	MAPK13	0.41145387
86	CSNK1A1	0.40014871
87	LCK	0.37919823
88	TRPM7	0.37803295
89	ATR	0.37657045
90	PRKACA	0.36429381
91	TNK2	0.33749008
92	NEK1	0.33372199
93	GRK5	0.33285582
94	PRKCA	0.32823281
95	CSNK2A2	0.32737289
96	IGF1R	0.32203467
97	GRK7	0.31051799
98	PIK3CG	0.30961732
99	IRAK4	0.29507056
100	WNK1	0.28383799

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.65813231
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.04326065
3	Proteasome_Homo sapiens_hsa03050	4.02549447
4	Parkinsons disease_Homo sapiens_hsa05012	3.26223387
5	Primary immunodeficiency_Homo sapiens_hsa05340	3.11930423
6	RNA polymerase_Homo sapiens_hsa03020	2.55181362
7	Alzheimers disease_Homo sapiens_hsa05010	2.35285468
8	Huntingtons disease_Homo sapiens_hsa05016	2.30901666
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.19794245
10	One carbon pool by folate_Homo sapiens_hsa00670	2.08268561
11	Cardiac muscle contraction_Homo sapiens_hsa04260	1.98147262
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.97955275
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.75385765
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.75096066
15	Sulfur relay system_Homo sapiens_hsa04122	1.73472765
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.70122786
17	Regulation of autophagy_Homo sapiens_hsa04140	1.53644460
18	Pyrimidine metabolism_Homo sapiens_hsa00240	1.43330978
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.43038769
20	RNA degradation_Homo sapiens_hsa03018	1.42193887
21	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.32747364
22	Basal transcription factors_Homo sapiens_hsa03022	1.31311146
23	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.30511223
24	Graft-versus-host disease_Homo sapiens_hsa05332	1.27633723
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.24034475
26	Arginine biosynthesis_Homo sapiens_hsa00220	1.22725114
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.22276734
28	Spliceosome_Homo sapiens_hsa03040	1.21398137
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.20267157
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.19338593
31	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.18842211
32	Allograft rejection_Homo sapiens_hsa05330	1.14339731
33	Purine metabolism_Homo sapiens_hsa00230	1.13932963
34	Homologous recombination_Homo sapiens_hsa03440	1.13242701
35	Protein export_Homo sapiens_hsa03060	1.12450544
36	Antigen processing and presentation_Homo sapiens_hsa04612	1.06968011
37	Linoleic acid metabolism_Homo sapiens_hsa00591	1.01454455
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.00662022
39	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.99890376
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.99744370
41	DNA replication_Homo sapiens_hsa03030	0.96599314
42	Phototransduction_Homo sapiens_hsa04744	0.92427169
43	Caffeine metabolism_Homo sapiens_hsa00232	0.91182559
44	Nucleotide excision repair_Homo sapiens_hsa03420	0.87086534
45	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.81645438
46	Folate biosynthesis_Homo sapiens_hsa00790	0.78290577
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.76771313
48	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.76271638
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.75194262
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.74750066
51	Peroxisome_Homo sapiens_hsa04146	0.74074085
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.73539857
53	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.71835116
54	Asthma_Homo sapiens_hsa05310	0.71587917
55	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.70950477
56	Type I diabetes mellitus_Homo sapiens_hsa04940	0.70741284
57	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.70597667
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.70475129
59	Fanconi anemia pathway_Homo sapiens_hsa03460	0.69475023
60	Metabolic pathways_Homo sapiens_hsa01100	0.68418075
61	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.67816213
62	Retinol metabolism_Homo sapiens_hsa00830	0.67193644
63	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.66894032
64	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.63721326
65	Mismatch repair_Homo sapiens_hsa03430	0.63107466
66	Tyrosine metabolism_Homo sapiens_hsa00350	0.62813343
67	Propanoate metabolism_Homo sapiens_hsa00640	0.59614791
68	Phenylalanine metabolism_Homo sapiens_hsa00360	0.58594161
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.58567971
70	Base excision repair_Homo sapiens_hsa03410	0.58449256
71	Morphine addiction_Homo sapiens_hsa05032	0.58359250
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57101446
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55224869
74	Sulfur metabolism_Homo sapiens_hsa00920	0.55222182
75	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.54922143
76	Olfactory transduction_Homo sapiens_hsa04740	0.54739832
77	RNA transport_Homo sapiens_hsa03013	0.54527558
78	Tight junction_Homo sapiens_hsa04530	0.51962576
79	Butanoate metabolism_Homo sapiens_hsa00650	0.51090461
80	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.50065847
81	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.49126322
82	Salivary secretion_Homo sapiens_hsa04970	0.47512636
83	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.46390397
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.46209800
85	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.45738515
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.43225308
87	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.41925198
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.40674317
89	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.39680745
90	Carbon metabolism_Homo sapiens_hsa01200	0.38457758
91	Nicotine addiction_Homo sapiens_hsa05033	0.37137458
92	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.37122695
93	mRNA surveillance pathway_Homo sapiens_hsa03015	0.32461697
94	Selenocompound metabolism_Homo sapiens_hsa00450	0.29031921
95	Glutathione metabolism_Homo sapiens_hsa00480	0.27825393
96	Taste transduction_Homo sapiens_hsa04742	0.26515741
97	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.26092811
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.24898222
99	Circadian entrainment_Homo sapiens_hsa04713	0.24082505
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.22563283

RPL18P13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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