RPL19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* viral transcription (GO:0019083)8.25460969
2ribosomal small subunit assembly (GO:0000028)8.14387474
3* translational termination (GO:0006415)7.95861983
4ribosomal small subunit biogenesis (GO:0042274)7.31117603
5* translational elongation (GO:0006414)6.93059015
6maturation of SSU-rRNA (GO:0030490)6.83781632
7* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.81879228
8* cotranslational protein targeting to membrane (GO:0006613)6.68650536
9* protein targeting to ER (GO:0045047)6.67685235
10* establishment of protein localization to endoplasmic reticulum (GO:0072599)6.38073509
11* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.34950444
12* protein localization to endoplasmic reticulum (GO:0070972)6.24010726
13* viral life cycle (GO:0019058)6.23349782
14* cellular protein complex disassembly (GO:0043624)6.19974957
15* translational initiation (GO:0006413)6.14665380
16ribosomal large subunit biogenesis (GO:0042273)5.62127065
17* protein complex disassembly (GO:0043241)5.47638247
18* macromolecular complex disassembly (GO:0032984)5.12394172
19formation of translation preinitiation complex (GO:0001731)4.86133425
20* nuclear-transcribed mRNA catabolic process (GO:0000956)4.63854329
21ribonucleoprotein complex biogenesis (GO:0022613)4.56776995
22* translation (GO:0006412)4.50707241
23* protein targeting to membrane (GO:0006612)4.44283982
24* mRNA catabolic process (GO:0006402)4.39555544
25* RNA catabolic process (GO:0006401)4.15289504
26DNA strand elongation involved in DNA replication (GO:0006271)3.88443563
27DNA unwinding involved in DNA replication (GO:0006268)3.79285916
28rRNA processing (GO:0006364)3.76600661
29DNA strand elongation (GO:0022616)3.68163849
30rRNA metabolic process (GO:0016072)3.61954575
31telomere maintenance via semi-conservative replication (GO:0032201)3.61385995
32regulation of transcription from RNA polymerase I promoter (GO:0006356)3.52771743
33establishment of integrated proviral latency (GO:0075713)3.50596863
34DNA deamination (GO:0045006)3.50121778
35DNA replication initiation (GO:0006270)3.43483548
36cellular component biogenesis (GO:0044085)3.38061045
37regulation of mitochondrial translation (GO:0070129)3.29720667
38ribosome biogenesis (GO:0042254)3.18435190
39transcription from mitochondrial promoter (GO:0006390)3.17646152
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15823491
41nucleobase biosynthetic process (GO:0046112)3.14933315
42telomere maintenance via recombination (GO:0000722)3.13656920
43folic acid-containing compound biosynthetic process (GO:0009396)3.12927350
44ribosome assembly (GO:0042255)3.11042022
45spliceosomal snRNP assembly (GO:0000387)3.08505361
46chaperone-mediated protein transport (GO:0072321)3.07688877
47* establishment of protein localization to membrane (GO:0090150)3.04744025
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.03458205
49protein localization to kinetochore (GO:0034501)2.98870165
50mitotic recombination (GO:0006312)2.98174769
51mitotic chromosome condensation (GO:0007076)2.95367519
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95076737
53negative regulation of ligase activity (GO:0051352)2.95076737
54respiratory electron transport chain (GO:0022904)2.95075031
55positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94738048
56* protein localization to membrane (GO:0072657)2.92414299
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91590547
58regulation of translational fidelity (GO:0006450)2.90547301
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.90437293
60anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90307759
61telomere maintenance via telomere lengthening (GO:0010833)2.89848623
62DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.89708471
63mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.89131875
64negative regulation of RNA splicing (GO:0033119)2.88881884
65electron transport chain (GO:0022900)2.87438197
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.86193743
67intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.86193743
68* establishment of protein localization to organelle (GO:0072594)2.86037938
69nucleotide-excision repair, DNA gap filling (GO:0006297)2.85520676
70pseudouridine synthesis (GO:0001522)2.84467294
71IMP biosynthetic process (GO:0006188)2.82962932
72ncRNA 3-end processing (GO:0043628)2.82704851
73signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.82294427
74signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.82294427
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.82294427
76signal transduction involved in DNA damage checkpoint (GO:0072422)2.81991098
77signal transduction involved in DNA integrity checkpoint (GO:0072401)2.81991098
78mitotic nuclear envelope disassembly (GO:0007077)2.81907864
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.81122731
80* protein targeting (GO:0006605)2.79830485
81DNA replication-dependent nucleosome organization (GO:0034723)2.78849891
82DNA replication-dependent nucleosome assembly (GO:0006335)2.78849891
83spliceosomal complex assembly (GO:0000245)2.78782716
84transcription-coupled nucleotide-excision repair (GO:0006283)2.78687612
85establishment of viral latency (GO:0019043)2.78579385
86signal transduction involved in cell cycle checkpoint (GO:0072395)2.76414904
87purine nucleobase biosynthetic process (GO:0009113)2.76408548
88deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.75128525
89DNA replication checkpoint (GO:0000076)2.74732130
90transcription elongation from RNA polymerase III promoter (GO:0006385)2.74301182
91termination of RNA polymerase III transcription (GO:0006386)2.74301182
92proteasome assembly (GO:0043248)2.72677387
93CENP-A containing nucleosome assembly (GO:0034080)2.72008999
94chromatin remodeling at centromere (GO:0031055)2.67603296
95protein targeting to mitochondrion (GO:0006626)2.67515444
96antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.67354349
97rRNA modification (GO:0000154)2.67114523
98energy coupled proton transport, down electrochemical gradient (GO:0015985)2.66960868
99ATP synthesis coupled proton transport (GO:0015986)2.66960868
100ncRNA processing (GO:0034470)2.66407005
101regulation of protein heterodimerization activity (GO:0043497)2.63051797
102RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.62222544
103mRNA splicing, via spliceosome (GO:0000398)2.62222544
104RNA splicing, via transesterification reactions (GO:0000375)2.61915905
105* gene expression (GO:0010467)2.60105228
106pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.58958580
107membrane disassembly (GO:0030397)2.58011652
108nuclear envelope disassembly (GO:0051081)2.58011652
109DNA replication-independent nucleosome assembly (GO:0006336)2.57008660
110DNA replication-independent nucleosome organization (GO:0034724)2.57008660
111ribonucleoprotein complex assembly (GO:0022618)2.56696513
112G1/S transition of mitotic cell cycle (GO:0000082)2.56525030
113cell cycle G1/S phase transition (GO:0044843)2.56525030
114exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.56511828
115negative regulation of T cell differentiation in thymus (GO:0033085)2.55549137
116ribonucleoprotein complex subunit organization (GO:0071826)2.55318322
117nucleobase-containing small molecule interconversion (GO:0015949)2.53357354
118* protein localization to organelle (GO:0033365)2.48638989
119nuclear pore complex assembly (GO:0051292)2.46582789
120oxidative phosphorylation (GO:0006119)2.45571345
121positive regulation of keratinocyte differentiation (GO:0045618)2.43074223
122ncRNA metabolic process (GO:0034660)2.42133762
123establishment of protein localization to mitochondrion (GO:0072655)2.39206343
124* cellular component disassembly (GO:0022411)2.38916953
125pentose metabolic process (GO:0019321)2.35557543
126regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.34887789
127negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.34759641
128spliceosomal tri-snRNP complex assembly (GO:0000244)2.34068845
129mitochondrial RNA metabolic process (GO:0000959)2.33656925
130GDP-mannose metabolic process (GO:0019673)2.31873409
131positive regulation of viral transcription (GO:0050434)2.29364686
132inner mitochondrial membrane organization (GO:0007007)2.29043153
133myeloid cell homeostasis (GO:0002262)2.28094406
134guanosine-containing compound biosynthetic process (GO:1901070)2.28031596
135protein localization to mitochondrion (GO:0070585)2.27390922
136regulation of translational initiation (GO:0006446)2.26734914
137mitotic sister chromatid segregation (GO:0000070)2.26658177

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.42729765
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.54186902
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.03065543
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.32862617
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.17757625
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.13394965
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.12938499
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.95571382
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83719558
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83340752
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80970831
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.80568796
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78542927
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65585349
15* XRN2_22483619_ChIP-Seq_HELA_Human2.61208888
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60472097
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59560575
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50046619
19* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40984426
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32250963
21* VDR_23849224_ChIP-Seq_CD4+_Human2.30146495
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26405648
23DCP1A_22483619_ChIP-Seq_HELA_Human2.06828971
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06096846
25* TTF2_22483619_ChIP-Seq_HELA_Human2.02675557
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01984693
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98666751
28FOXP3_21729870_ChIP-Seq_TREG_Human1.98069311
29ZNF263_19887448_ChIP-Seq_K562_Human1.96741928
30* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.94288149
31* MYC_22102868_ChIP-Seq_BL_Human1.84806267
32* ELK1_19687146_ChIP-ChIP_HELA_Human1.82699443
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80948686
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76758022
35GABP_19822575_ChIP-Seq_HepG2_Human1.76702670
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74208735
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.70005284
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67013796
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66852798
40CIITA_25753668_ChIP-Seq_RAJI_Human1.61443296
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54115773
42* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53563354
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52057618
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50544977
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.49552321
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49120156
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48065463
48* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47449460
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45064027
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.43369704
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42498787
52VDR_21846776_ChIP-Seq_THP-1_Human1.42002975
53AR_21909140_ChIP-Seq_LNCAP_Human1.41278289
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41088356
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39201740
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38096150
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31700686
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.31673618
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30855855
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30530942
61KDM5A_27292631_Chip-Seq_BREAST_Human1.29232072
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.28913042
63* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28521868
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27752241
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25828085
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23879807
67* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23170378
68* ELK1_22589737_ChIP-Seq_MCF10A_Human1.21896417
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20011156
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17479081
71SPI1_23547873_ChIP-Seq_NB4_Human1.16914931
72* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16234767
73SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15306743
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14943408
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14822573
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13080257
77* TFEB_21752829_ChIP-Seq_HELA_Human1.12663732
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10416898
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09283404
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08835786
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08404620
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07762789
83* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07473645
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07109997
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.06697541
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06141483
87* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04568549
88MAF_26560356_Chip-Seq_TH2_Human1.03560020
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03080728
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02815603
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00310966
92* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00256465
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00218384
94TET1_21451524_ChIP-Seq_MESCs_Mouse0.95866196
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95480697
96MYC_18940864_ChIP-ChIP_HL60_Human0.95289518
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94823842
98OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94429591
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93734382
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93067718
101CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92967422
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92383710
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92356093
104TP63_19390658_ChIP-ChIP_HaCaT_Human0.90863521
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90336472
106TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88907291
107RACK7_27058665_Chip-Seq_MCF-7_Human0.88630710
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88553573
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86695373
110SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86496875
111FOXP1_21924763_ChIP-Seq_HESCs_Human0.85779999
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85718623
113UTX_26944678_Chip-Seq_JUKART_Human0.85514935
114LXR_22292898_ChIP-Seq_THP-1_Human0.84892312
115MAF_26560356_Chip-Seq_TH1_Human0.84592587
116MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.84427881
117CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84172747
118STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84009713
119SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83421926
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83320363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.72426669
2MP0004957_abnormal_blastocyst_morpholog4.01341249
3MP0009379_abnormal_foot_pigmentation3.42885087
4MP0003077_abnormal_cell_cycle3.33721580
5MP0010094_abnormal_chromosome_stability3.30777066
6MP0003111_abnormal_nucleus_morphology3.22997969
7MP0008057_abnormal_DNA_replication2.82194719
8MP0002396_abnormal_hematopoietic_system2.42465950
9MP0008007_abnormal_cellular_replicative2.37976613
10MP0008058_abnormal_DNA_repair2.36306360
11MP0010352_gastrointestinal_tract_polyps2.35048046
12MP0008932_abnormal_embryonic_tissue2.11983196
13MP0003763_abnormal_thymus_physiology2.03409130
14MP0009333_abnormal_splenocyte_physiolog1.98989766
15MP0001730_embryonic_growth_arrest1.96398188
16MP0000490_abnormal_crypts_of1.96247465
17MP0003123_paternal_imprinting1.89183238
18MP0000350_abnormal_cell_proliferation1.87753178
19MP0004264_abnormal_extraembryonic_tissu1.82286624
20MP0003786_premature_aging1.80222319
21MP0004808_abnormal_hematopoietic_stem1.77980907
22MP0006054_spinal_hemorrhage1.65564656
23MP0002398_abnormal_bone_marrow1.56990107
24MP0000685_abnormal_immune_system1.56168930
25MP0001835_abnormal_antigen_presentation1.56160666
26MP0005451_abnormal_body_composition1.50960210
27MP0002877_abnormal_melanocyte_morpholog1.48902477
28MP0000703_abnormal_thymus_morphology1.48684668
29MP0006036_abnormal_mitochondrial_physio1.47251104
30MP0001881_abnormal_mammary_gland1.46296428
31MP0002722_abnormal_immune_system1.45771718
32MP0002019_abnormal_tumor_incidence1.45412961
33MP0001697_abnormal_embryo_size1.38124323
34MP0010307_abnormal_tumor_latency1.37143468
35MP0002080_prenatal_lethality1.36967905
36MP0000313_abnormal_cell_death1.35471172
37MP0000689_abnormal_spleen_morphology1.34684534
38MP0005397_hematopoietic_system_phenotyp1.33369142
39MP0001545_abnormal_hematopoietic_system1.33369142
40MP0001800_abnormal_humoral_immune1.32605191
41MP0003567_abnormal_fetal_cardiomyocyte1.32271821
42MP0000678_abnormal_parathyroid_gland1.30844758
43MP0000858_altered_metastatic_potential1.24738112
44MP0002429_abnormal_blood_cell1.24493509
45MP0006035_abnormal_mitochondrial_morpho1.23980329
46MP0005671_abnormal_response_to1.23788409
47MP0005380_embryogenesis_phenotype1.22354392
48MP0001672_abnormal_embryogenesis/_devel1.22354392
49MP0000716_abnormal_immune_system1.20472717
50MP0001853_heart_inflammation1.19689964
51MP0002166_altered_tumor_susceptibility1.19565936
52MP0002420_abnormal_adaptive_immunity1.19223173
53MP0001819_abnormal_immune_cell1.17271652
54MP0006292_abnormal_olfactory_placode1.16528242
55MP0004197_abnormal_fetal_growth/weight/1.16010385
56MP0002084_abnormal_developmental_patter1.15120974
57MP0002085_abnormal_embryonic_tissue1.14685631
58MP0002452_abnormal_antigen_presenting1.14503070
59MP0000372_irregular_coat_pigmentation1.12901717
60MP0002132_abnormal_respiratory_system1.12667032
61MP0000537_abnormal_urethra_morphology1.12664447
62MP0002086_abnormal_extraembryonic_tissu1.12061605
63MP0003984_embryonic_growth_retardation1.10256591
64MP0002088_abnormal_embryonic_growth/wei1.08828375
65MP0002723_abnormal_immune_serum1.07751261
66MP0002006_tumorigenesis1.06282243
67MP0002405_respiratory_system_inflammati1.06230672
68MP0004185_abnormal_adipocyte_glucose1.04730299
69MP0005000_abnormal_immune_tolerance1.01724662
70MP0005023_abnormal_wound_healing1.01645992
71MP0005174_abnormal_tail_pigmentation1.00213624
72MP0005501_abnormal_skin_physiology0.99268044
73MP0000627_abnormal_mammary_gland0.98355614
74MP0000358_abnormal_cell_content/0.96519632
75MP0003186_abnormal_redox_activity0.96339538
76MP0005025_abnormal_response_to0.95807617
77MP0009785_altered_susceptibility_to0.95675610
78MP0003866_abnormal_defecation0.95062046
79MP0003943_abnormal_hepatobiliary_system0.94313185
80MP0010155_abnormal_intestine_physiology0.93777775
81MP0003436_decreased_susceptibility_to0.93702540
82MP0004381_abnormal_hair_follicle0.92882056
83MP0003315_abnormal_perineum_morphology0.92763375
84MP0004133_heterotaxia0.92409195
85MP0002938_white_spotting0.92094665
86MP0000465_gastrointestinal_hemorrhage0.91922344
87MP0001293_anophthalmia0.91504862
88MP0003566_abnormal_cell_adhesion0.90847086
89MP0005075_abnormal_melanosome_morpholog0.90302799
90MP0002095_abnormal_skin_pigmentation0.90288011
91MP0010030_abnormal_orbit_morphology0.88863425
92MP0003806_abnormal_nucleotide_metabolis0.87951572
93MP0008995_early_reproductive_senescence0.87702530
94MP0001764_abnormal_homeostasis0.86911313
95MP0002148_abnormal_hypersensitivity_rea0.86237836
96MP0009278_abnormal_bone_marrow0.84611938
97MP0003718_maternal_effect0.84370195
98MP0003121_genomic_imprinting0.81981219
99MP0000477_abnormal_intestine_morphology0.79992309
100MP0001873_stomach_inflammation0.79551509
101MP0002098_abnormal_vibrissa_morphology0.79480037
102MP0001790_abnormal_immune_system0.78701389
103MP0005387_immune_system_phenotype0.78701389
104MP0005058_abnormal_lysosome_morphology0.77191122
105MP0005076_abnormal_cell_differentiation0.76202719
106MP0002009_preneoplasia0.76132916
107MP0004947_skin_inflammation0.74649177
108MP0003941_abnormal_skin_development0.73102879
109MP0008260_abnormal_autophagy0.70755807
110MP0003448_altered_tumor_morphology0.68778208
111MP0001727_abnormal_embryo_implantation0.68635564
112MP0002796_impaired_skin_barrier0.68164192
113MP0000681_abnormal_thyroid_gland0.67710286
114MP0005384_cellular_phenotype0.67502867
115MP0010234_abnormal_vibrissa_follicle0.67293279
116MP0002210_abnormal_sex_determination0.67127908
117MP0002163_abnormal_gland_morphology0.67100664
118MP0002111_abnormal_tail_morphology0.66393703
119MP0000609_abnormal_liver_physiology0.66216362
120MP0000750_abnormal_muscle_regeneration0.65924909
121MP0001216_abnormal_epidermal_layer0.65379033
122MP0005408_hypopigmentation0.65020150
123MP0008877_abnormal_DNA_methylation0.62793391

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)8.54010501
2Abnormal number of erythroid precursors (HP:0012131)7.46546743
3Reticulocytopenia (HP:0001896)7.41796338
4Macrocytic anemia (HP:0001972)5.44821970
5Pallor (HP:0000980)5.14142837
6Acute encephalopathy (HP:0006846)4.17514217
7Colon cancer (HP:0003003)3.90203577
8Progressive macrocephaly (HP:0004481)3.79684243
9Thrombocytosis (HP:0001894)3.71689541
10Cerebral edema (HP:0002181)3.58683462
11Microvesicular hepatic steatosis (HP:0001414)3.38703556
12Increased intramyocellular lipid droplets (HP:0012240)3.34458230
1311 pairs of ribs (HP:0000878)3.32201522
14Aplastic anemia (HP:0001915)3.30761159
15Birth length less than 3rd percentile (HP:0003561)3.15733390
16Oral leukoplakia (HP:0002745)3.02512434
17Absent thumb (HP:0009777)2.97279760
18Selective tooth agenesis (HP:0001592)2.97142394
19Aplasia/Hypoplasia of the sacrum (HP:0008517)2.93895770
20Increased muscle lipid content (HP:0009058)2.91369364
21IgM deficiency (HP:0002850)2.86252166
22Multiple enchondromatosis (HP:0005701)2.80156575
23Trismus (HP:0000211)2.78778145
24Stenosis of the external auditory canal (HP:0000402)2.75889448
25Exercise intolerance (HP:0003546)2.71784310
26Breast hypoplasia (HP:0003187)2.69709891
27Rough bone trabeculation (HP:0100670)2.61211957
28Abnormality of reticulocytes (HP:0004312)2.60319715
29Renal Fanconi syndrome (HP:0001994)2.58298417
303-Methylglutaconic aciduria (HP:0003535)2.58293846
31Reduced antithrombin III activity (HP:0001976)2.52377703
32Progressive muscle weakness (HP:0003323)2.48464320
33Seborrheic dermatitis (HP:0001051)2.48020062
34Microretrognathia (HP:0000308)2.46012338
35Leukodystrophy (HP:0002415)2.44435860
36Carpal bone hypoplasia (HP:0001498)2.42315730
37Abnormal hemoglobin (HP:0011902)2.41790252
38Asplenia (HP:0001746)2.40640066
39B lymphocytopenia (HP:0010976)2.39256489
40Lactic acidosis (HP:0003128)2.37922052
41Depressed nasal ridge (HP:0000457)2.32035822
42Missing ribs (HP:0000921)2.29020777
43Basal cell carcinoma (HP:0002671)2.28709799
44Glossoptosis (HP:0000162)2.28687659
45Neoplasm of the pancreas (HP:0002894)2.25510905
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25087004
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25087004
48Increased serum lactate (HP:0002151)2.24911225
49Premature graying of hair (HP:0002216)2.24543291
50Myelodysplasia (HP:0002863)2.22699382
51Aplasia/Hypoplasia of the spleen (HP:0010451)2.20408283
52Respiratory failure (HP:0002878)2.18737721
53Increased hepatocellular lipid droplets (HP:0006565)2.16489436
54Agnosia (HP:0010524)2.15651304
55Agammaglobulinemia (HP:0004432)2.15064911
56Patellar aplasia (HP:0006443)2.14499244
57Hepatic necrosis (HP:0002605)2.09496264
58Degeneration of anterior horn cells (HP:0002398)2.08864635
59Abnormality of the anterior horn cell (HP:0006802)2.08864635
60Abnormal number of incisors (HP:0011064)2.07686373
61Lymphoma (HP:0002665)2.07322327
62Cellular immunodeficiency (HP:0005374)2.05515641
63Acute lymphatic leukemia (HP:0006721)2.03441670
64Elevated erythrocyte sedimentation rate (HP:0003565)2.02855777
65Thick lower lip vermilion (HP:0000179)2.02417647
66Exertional dyspnea (HP:0002875)2.02126843
67Hyperthyroidism (HP:0000836)2.01752971
68Gastrointestinal stroma tumor (HP:0100723)2.01249367
69Aplasia/Hypoplasia of the patella (HP:0006498)2.00801028
70Ependymoma (HP:0002888)2.00788668
71Autoimmune hemolytic anemia (HP:0001890)2.00722316
72Acute necrotizing encephalopathy (HP:0006965)2.00403855
73Atresia of the external auditory canal (HP:0000413)1.97501948
74Amaurosis fugax (HP:0100576)1.97039541
75Mitochondrial inheritance (HP:0001427)1.93921792
76Cleft eyelid (HP:0000625)1.93279804
77Cerebral hypomyelination (HP:0006808)1.93243318
78Hypoplasia of the radius (HP:0002984)1.92910188
79Abnormality of glycolysis (HP:0004366)1.92558027
80Ragged-red muscle fibers (HP:0003200)1.92091903
81Hypertensive crisis (HP:0100735)1.91722422
82Abnormality of methionine metabolism (HP:0010901)1.90216835
83Abnormality of B cell number (HP:0010975)1.89486976
84Chronic otitis media (HP:0000389)1.89431129
85Abnormality of the thymus (HP:0000777)1.88033231
86Migraine (HP:0002076)1.87717288
87Congenital, generalized hypertrichosis (HP:0004540)1.86732239
88Squamous cell carcinoma (HP:0002860)1.85864789
89Esophageal neoplasm (HP:0100751)1.85193532
90Neoplasm of head and neck (HP:0012288)1.85193532
91Triphalangeal thumb (HP:0001199)1.85000669
92Abnormality of the preputium (HP:0100587)1.84031390
93Abnormal trabecular bone morphology (HP:0100671)1.83902227
94Respiratory difficulties (HP:0002880)1.83322637
95Obstructive lung disease (HP:0006536)1.82340317
96Chronic obstructive pulmonary disease (HP:0006510)1.82340317
97Petechiae (HP:0000967)1.82277407
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.82045529
99Increased serum pyruvate (HP:0003542)1.81744001
100Medulloblastoma (HP:0002885)1.81579915
101Villous atrophy (HP:0011473)1.81522098
102Abnormality of small intestinal villus morphology (HP:0011472)1.81522098
103Recurrent bronchitis (HP:0002837)1.79153049
104Abnormality of T cells (HP:0002843)1.78577276
105Lipid accumulation in hepatocytes (HP:0006561)1.78269025
106Colitis (HP:0002583)1.76418347
107Abnormal mitochondria in muscle tissue (HP:0008316)1.76343415
108Horseshoe kidney (HP:0000085)1.75101623
109Optic disc pallor (HP:0000543)1.74869261
110Proximal placement of thumb (HP:0009623)1.74802262
111Hepatocellular necrosis (HP:0001404)1.73791131
112Bone marrow hypocellularity (HP:0005528)1.73584387
113Glioma (HP:0009733)1.73563059
114Premature ovarian failure (HP:0008209)1.73510462
115Increased CSF lactate (HP:0002490)1.73292179
116Poikiloderma (HP:0001029)1.73227374
117Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72401310
118Progressive external ophthalmoplegia (HP:0000590)1.72221044
119Abnormal protein glycosylation (HP:0012346)1.71149506
120Abnormal glycosylation (HP:0012345)1.71149506
121Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71149506
122Abnormal protein N-linked glycosylation (HP:0012347)1.71149506
123Tracheoesophageal fistula (HP:0002575)1.71005164
124Abnormality of T cell physiology (HP:0011840)1.70295930
125Hyperacusis (HP:0010780)1.67952700
126Lethargy (HP:0001254)1.67632704
127Deviation of the thumb (HP:0009603)1.67067788
128Pancytopenia (HP:0001876)1.66094601
129IgG deficiency (HP:0004315)1.65557478
130Hypoparathyroidism (HP:0000829)1.65456925
131Meckel diverticulum (HP:0002245)1.64533827
132Sparse eyelashes (HP:0000653)1.64331096
133Recurrent viral infections (HP:0004429)1.63887481
134Aplasia/Hypoplasia of the thymus (HP:0010515)1.63860911
135Absent radius (HP:0003974)1.63577254
136Secondary amenorrhea (HP:0000869)1.63066209
137Panhypogammaglobulinemia (HP:0003139)1.62338324
138Optic nerve coloboma (HP:0000588)1.61016197
139Abnormality of the ileum (HP:0001549)1.60627815
140Neoplasm of the colon (HP:0100273)1.59990329
141Type I transferrin isoform profile (HP:0003642)1.59838866
142Irregular epiphyses (HP:0010582)1.58199889
143Absent rod-and cone-mediated responses on ERG (HP:0007688)1.58007432
144T lymphocytopenia (HP:0005403)1.57516806
145Truncus arteriosus (HP:0001660)1.57084208
146Abnormality of DNA repair (HP:0003254)1.56957242
147Thoracic kyphosis (HP:0002942)1.56874205
148Abnormality of aspartate family amino acid metabolism (HP:0010899)1.56403500
149Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.55937688
150Abnormality of the fetal cardiovascular system (HP:0010948)1.55388796
151Abnormal umbilical cord blood vessels (HP:0011403)1.55388796
152Single umbilical artery (HP:0001195)1.55388796
153Abnormality of chromosome stability (HP:0003220)1.53746380
154Bicuspid aortic valve (HP:0001647)1.53535152

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.72970564
2BUB13.68988271
3WEE13.47788616
4VRK23.14673578
5SMG12.94670971
6EEF2K2.75885995
7RPS6KB22.67943579
8CDC72.54699859
9MATK2.44272535
10PASK2.36990002
11LRRK22.34301741
12TGFBR12.16159891
13MAP4K12.15891835
14PRPF4B2.04680554
15EIF2AK11.97494835
16SRPK11.95612717
17NEK21.87139800
18TSSK61.80697216
19PIM21.79308632
20VRK11.78350456
21TESK21.71032420
22STK161.70460414
23DYRK31.66695069
24MST41.64603482
25EPHA21.61907864
26RPS6KA41.61516755
27EIF2AK31.60724836
28SCYL21.50968145
29MAP3K101.48888193
30AURKB1.48167891
31STK101.44047250
32BRSK21.41179331
33ACVR1B1.40818288
34TLK11.39787380
35FLT31.38545881
36CDK71.37931994
37PAK41.32082506
38PKN21.31670342
39RIPK41.30370965
40MAP3K81.28269609
41PLK11.24607988
42ICK1.20743610
43TAF11.20279338
44TTK1.19056654
45ATR1.18873724
46MAPKAPK31.14163119
47PIM11.14086849
48KDR1.13633514
49MKNK11.11002340
50ILK1.10650241
51ZAP701.09922934
52GRK61.09848596
53PLK41.08868850
54CDK41.07928494
55BTK1.07441290
56ARAF1.06376655
57NME10.95054471
58NEK10.94404906
59MAP2K30.93892513
60AURKA0.93229438
61STK40.91980671
62BCKDK0.83256748
63ERN10.83224932
64TYK20.81186050
65TESK10.78454204
66CSNK2A20.78246310
67JAK30.77632844
68IRAK30.77426158
69RPS6KA50.76909473
70MAP3K30.76161142
71PLK30.75803423
72FGFR40.75789359
73BLK0.74131952
74* CHEK10.71268785
75CHEK20.71076922
76IKBKB0.71013905
77TEC0.69943907
78SIK10.67641754
79PAK10.67252145
80BRSK10.65730021
81BRAF0.65533829
82MST1R0.64683361
83KIT0.64067959
84MAP3K110.63422029
85CSNK2A10.60777167
86PDK20.60177298
87PRKCI0.59605192
88SYK0.55875313
89CDK120.54995345
90CDK190.54737462
91ABL20.53118882
92CSF1R0.52778848
93CDK60.52064011
94IRAK40.51246395
95CDK20.50025339
96PAK20.49826989
97LCK0.48553470
98ITK0.48467369
99MAP2K20.48080305
100TRIB30.47307429
101ATM0.47258387
102CDK80.46935554
103ZAK0.46815439
104ALK0.45342298
105MAP3K130.44853611
106TAOK20.44793822
107NLK0.43186220
108TBK10.41407013
109LYN0.40306361
110BRD40.39550596
111MARK30.38502842
112PBK0.38330774
113TXK0.37653471
114LIMK10.36152002
115MAPKAPK20.35265391
116CDK10.34639383
117MAPK110.34226001
118MAP3K140.34058280
119MTOR0.33494389
120RPS6KA60.33408589
121AKT20.32968793
122CLK10.32890102
123HIPK20.32317131
124RPS6KL10.32274463
125RPS6KC10.32274463
126MELK0.28752670
127DAPK30.27854641

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030106.57755607
2DNA replication_Homo sapiens_hsa030304.00505676
3Proteasome_Homo sapiens_hsa030503.69803270
4Mismatch repair_Homo sapiens_hsa034303.43269568
5RNA polymerase_Homo sapiens_hsa030203.23776958
6Spliceosome_Homo sapiens_hsa030403.13699493
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.94032061
8RNA transport_Homo sapiens_hsa030132.57267952
9Nucleotide excision repair_Homo sapiens_hsa034202.46692410
10Base excision repair_Homo sapiens_hsa034102.45121437
11Pyrimidine metabolism_Homo sapiens_hsa002402.35417241
12Homologous recombination_Homo sapiens_hsa034402.31140230
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.04244446
14One carbon pool by folate_Homo sapiens_hsa006701.94355476
15Cell cycle_Homo sapiens_hsa041101.84835273
16Non-homologous end-joining_Homo sapiens_hsa034501.75560360
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60329822
18Protein export_Homo sapiens_hsa030601.57361710
19RNA degradation_Homo sapiens_hsa030181.55615946
20Parkinsons disease_Homo sapiens_hsa050121.46439499
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44967079
22Fanconi anemia pathway_Homo sapiens_hsa034601.42450404
23Oxidative phosphorylation_Homo sapiens_hsa001901.41281385
24p53 signaling pathway_Homo sapiens_hsa041151.39839123
25Basal transcription factors_Homo sapiens_hsa030221.37645033
26Primary immunodeficiency_Homo sapiens_hsa053401.35785414
27Antigen processing and presentation_Homo sapiens_hsa046121.31293443
28Epstein-Barr virus infection_Homo sapiens_hsa051691.24532055
29mRNA surveillance pathway_Homo sapiens_hsa030151.22266623
30Huntingtons disease_Homo sapiens_hsa050161.20038478
31Systemic lupus erythematosus_Homo sapiens_hsa053221.16290944
32Purine metabolism_Homo sapiens_hsa002301.08947435
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95972466
34Viral carcinogenesis_Homo sapiens_hsa052030.94113877
35Herpes simplex infection_Homo sapiens_hsa051680.93484878
36Carbon metabolism_Homo sapiens_hsa012000.92422343
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88587951
38Pancreatic cancer_Homo sapiens_hsa052120.84712911
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79421274
40Alzheimers disease_Homo sapiens_hsa050100.77856225
41Non-small cell lung cancer_Homo sapiens_hsa052230.76355724
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75629993
43HTLV-I infection_Homo sapiens_hsa051660.74658049
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.74511444
45Legionellosis_Homo sapiens_hsa051340.70765039
46Hematopoietic cell lineage_Homo sapiens_hsa046400.69212757
47Sulfur relay system_Homo sapiens_hsa041220.67058975
48Measles_Homo sapiens_hsa051620.65993579
49Pyruvate metabolism_Homo sapiens_hsa006200.65728113
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.65485061
51Folate biosynthesis_Homo sapiens_hsa007900.64181387
52Small cell lung cancer_Homo sapiens_hsa052220.63007727
53Pentose phosphate pathway_Homo sapiens_hsa000300.62306048
54Shigellosis_Homo sapiens_hsa051310.60266066
55Apoptosis_Homo sapiens_hsa042100.59978959
56Thyroid cancer_Homo sapiens_hsa052160.59094745
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56450259
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55374261
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.51429785
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.49054190
61Glutathione metabolism_Homo sapiens_hsa004800.48222409
62Allograft rejection_Homo sapiens_hsa053300.48115046
63Other glycan degradation_Homo sapiens_hsa005110.48059377
64N-Glycan biosynthesis_Homo sapiens_hsa005100.45779775
65Galactose metabolism_Homo sapiens_hsa000520.45313686
66Alcoholism_Homo sapiens_hsa050340.44860314
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44714078
68Fructose and mannose metabolism_Homo sapiens_hsa000510.44682197
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44441269
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42645512
71Graft-versus-host disease_Homo sapiens_hsa053320.41398317
72Hepatitis B_Homo sapiens_hsa051610.41340626
73MicroRNAs in cancer_Homo sapiens_hsa052060.41322289
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40501734
75Acute myeloid leukemia_Homo sapiens_hsa052210.39951706
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39841855
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39027572
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.38886929
79Cardiac muscle contraction_Homo sapiens_hsa042600.37738728
80Chronic myeloid leukemia_Homo sapiens_hsa052200.37717406
81B cell receptor signaling pathway_Homo sapiens_hsa046620.37652369
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37456970
83Leishmaniasis_Homo sapiens_hsa051400.36970213
84T cell receptor signaling pathway_Homo sapiens_hsa046600.36851268
85Asthma_Homo sapiens_hsa053100.36204793
86Fatty acid elongation_Homo sapiens_hsa000620.35360825
87Notch signaling pathway_Homo sapiens_hsa043300.34970603
88Renal cell carcinoma_Homo sapiens_hsa052110.34530112
89Bladder cancer_Homo sapiens_hsa052190.34069293
90Viral myocarditis_Homo sapiens_hsa054160.33997673
91Oocyte meiosis_Homo sapiens_hsa041140.33198486
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33128403
93Colorectal cancer_Homo sapiens_hsa052100.32169899
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31661739
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.30783280
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.30477721
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.30337994
98Biosynthesis of amino acids_Homo sapiens_hsa012300.30169387
99HIF-1 signaling pathway_Homo sapiens_hsa040660.29372073
100Influenza A_Homo sapiens_hsa051640.29335415
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28879050
102Endometrial cancer_Homo sapiens_hsa052130.27952835
103Type I diabetes mellitus_Homo sapiens_hsa049400.26774483
104Pathways in cancer_Homo sapiens_hsa052000.26666960
105Basal cell carcinoma_Homo sapiens_hsa052170.26427255
106Prostate cancer_Homo sapiens_hsa052150.26062561
107TGF-beta signaling pathway_Homo sapiens_hsa043500.25907268
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25459928
109Toxoplasmosis_Homo sapiens_hsa051450.25001046
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21368672
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19708941
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19525011
113Tyrosine metabolism_Homo sapiens_hsa003500.19457393
114Autoimmune thyroid disease_Homo sapiens_hsa053200.18316030
115Vitamin digestion and absorption_Homo sapiens_hsa049770.18057814
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17979728
117Hippo signaling pathway_Homo sapiens_hsa043900.17813143
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17165564
119Metabolic pathways_Homo sapiens_hsa011000.15935951
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14658009
121Selenocompound metabolism_Homo sapiens_hsa004500.14276056
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13603291

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