ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.44656095
2	maturation of SSU-rRNA (GO:0030490)	6.19273521
3	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	6.17973390
4	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	6.06913705
5	regulation of female gonad development (GO:2000194)	5.88390017
6	ribosomal small subunit biogenesis (GO:0042274)	5.64676845
7	piRNA metabolic process (GO:0034587)	5.56982050
8	chaperone-mediated protein transport (GO:0072321)	5.53974831
9	viral transcription (GO:0019083)	5.35634220
10	pyrimidine nucleotide catabolic process (GO:0006244)	5.24193736
11	regulation of retinoic acid receptor signaling pathway (GO:0048385)	5.20477075
12	translational termination (GO:0006415)	5.12902581
13	regulation of DNA methylation (GO:0044030)	5.06147975
14	regulation of acrosome reaction (GO:0060046)	5.04138041
15	base-excision repair, AP site formation (GO:0006285)	5.01726207
16	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.97375037
17	DNA deamination (GO:0045006)	4.80703986
18	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	4.62304999
19	meiotic cell cycle (GO:0051321)	4.60660821
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.58864921
21	protein targeting to ER (GO:0045047)	4.53361270
22	cotranslational protein targeting to membrane (GO:0006613)	4.51869505
23	multicellular organism reproduction (GO:0032504)	4.51491866
24	translational elongation (GO:0006414)	4.48656891
25	regulation of meiosis I (GO:0060631)	4.38917090
26	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.28544034
27	protein localization to endoplasmic reticulum (GO:0070972)	4.17232577
28	DNA methylation involved in gamete generation (GO:0043046)	4.10633762
29	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.00469774
30	male meiosis I (GO:0007141)	3.96735959
31	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.89518481
32	viral life cycle (GO:0019058)	3.86216376
33	cellular protein complex disassembly (GO:0043624)	3.85597889
34	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.76789074
35	translational initiation (GO:0006413)	3.71179839
36	protein neddylation (GO:0045116)	3.69545841
37	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.69073789
38	termination of RNA polymerase III transcription (GO:0006386)	3.69073789
39	synapsis (GO:0007129)	3.64840893
40	negative regulation of reproductive process (GO:2000242)	3.62058445
41	positive regulation of histone H3-K4 methylation (GO:0051571)	3.61034358
42	protein complex biogenesis (GO:0070271)	3.55690677
43	female gamete generation (GO:0007292)	3.55168748
44	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.53207334
45	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.53207334
46	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.46703560
47	NADH dehydrogenase complex assembly (GO:0010257)	3.46703560
48	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.46703560
49	cytidine deamination (GO:0009972)	3.36084389
50	cytidine metabolic process (GO:0046087)	3.36084389
51	cytidine catabolic process (GO:0006216)	3.36084389
52	respiratory electron transport chain (GO:0022904)	3.30199402
53	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.29603795
54	ATP synthesis coupled proton transport (GO:0015986)	3.29603795
55	negative regulation of execution phase of apoptosis (GO:1900118)	3.28508703
56	translation (GO:0006412)	3.28062518
57	electron transport chain (GO:0022900)	3.27454784
58	deoxyribonucleotide catabolic process (GO:0009264)	3.25699766
59	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.25676671
60	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.22764338
61	retinal cone cell development (GO:0046549)	3.21515421
62	mitochondrial respiratory chain complex assembly (GO:0033108)	3.16391298
63	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.13789773
64	axonemal dynein complex assembly (GO:0070286)	3.10916941
65	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.10684981
66	protein kinase C signaling (GO:0070528)	3.10202218
67	protein complex disassembly (GO:0043241)	3.09756959
68	negative regulation of telomere maintenance (GO:0032205)	3.06334046
69	chromatin remodeling at centromere (GO:0031055)	3.02869940
70	positive regulation of humoral immune response (GO:0002922)	3.01715169
71	deoxyribose phosphate catabolic process (GO:0046386)	3.00110403
72	mRNA catabolic process (GO:0006402)	2.98702416
73	glycine transport (GO:0015816)	2.98401689
74	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.98222354
75	ncRNA catabolic process (GO:0034661)	2.97323832
76	meiosis I (GO:0007127)	2.96860476
77	macromolecular complex disassembly (GO:0032984)	2.95470043
78	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.92452878
79	substrate-independent telencephalic tangential migration (GO:0021826)	2.92317186
80	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.92317186
81	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.92007688
82	protein targeting to membrane (GO:0006612)	2.91653404
83	rRNA processing (GO:0006364)	2.88151049
84	cellular component biogenesis (GO:0044085)	2.88006608
85	rRNA catabolic process (GO:0016075)	2.87711881
86	chromatin assembly (GO:0031497)	2.85013083
87	CENP-A containing nucleosome assembly (GO:0034080)	2.84630598
88	ribosomal large subunit biogenesis (GO:0042273)	2.84391291
89	rRNA metabolic process (GO:0016072)	2.83611157
90	epithelial cilium movement (GO:0003351)	2.83089480
91	oocyte development (GO:0048599)	2.81024829
92	maturation of 5.8S rRNA (GO:0000460)	2.79968529
93	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.79871601
94	ribonucleoprotein complex biogenesis (GO:0022613)	2.78732291
95	negative regulation of T cell differentiation in thymus (GO:0033085)	2.78656876
96	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.76785257
97	RNA catabolic process (GO:0006401)	2.74810407
98	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.71151400
99	resolution of meiotic recombination intermediates (GO:0000712)	2.70401885
100	ncRNA 3-end processing (GO:0043628)	2.69814344

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	9.45179982
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.72261094
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.38793748
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.85269757
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.73919589
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.54985954
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.40334047
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.83943305
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.55179847
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.55134036
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.48068746
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.43101572
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.38711751
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.16947346
15	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.07387728
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.06789922
17	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.92345872
18	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.92345872
19	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.92345872
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.89505035
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.87559717
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.86660651
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.82678951
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.82421041
25	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.77391787
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.60909068
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.60003955
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.59280105
29	NANOG_20526341_ChIP-Seq_ESCs_Human	1.55762973
30	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.54756770
31	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.52244108
32	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46500189
33	VDR_22108803_ChIP-Seq_LS180_Human	1.44475638
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44309319
35	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.41408138
36	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.39418970
37	TAF2_19829295_ChIP-Seq_ESCs_Human	1.36285793
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.35065036
39	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.28967827
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27002759
41	EWS_26573619_Chip-Seq_HEK293_Human	1.26769855
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.26721358
43	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.22440364
44	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.21392022
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.20843063
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20671119
47	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.17449649
48	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.11606922
49	GABP_19822575_ChIP-Seq_HepG2_Human	1.10615702
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05896574
51	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.05765143
52	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.04995965
53	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.04919169
54	AR_20517297_ChIP-Seq_VCAP_Human	1.04794270
55	NCOR_22424771_ChIP-Seq_293T_Human	1.03630240
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02460968
57	TTF2_22483619_ChIP-Seq_HELA_Human	1.02173547
58	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.00363466
59	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.99424607
60	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.98079993
61	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.97207224
62	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.96623693
63	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.95915345
64	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.93862261
65	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.91738959
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.91167190
67	HTT_18923047_ChIP-ChIP_STHdh_Human	0.90816613
68	ERG_20517297_ChIP-Seq_VCAP_Human	0.90256200
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.88706508
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.88706508
71	IRF1_19129219_ChIP-ChIP_H3396_Human	0.88287137
72	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.88164737
73	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.87954830
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.87036348
75	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.86550942
76	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.86452018
77	CTCF_20526341_ChIP-Seq_ESCs_Human	0.86081343
78	P53_21459846_ChIP-Seq_SAOS-2_Human	0.85911069
79	MYC_19829295_ChIP-Seq_ESCs_Human	0.85626862
80	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.85473004
81	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.84334402
82	CBP_20019798_ChIP-Seq_JUKART_Human	0.84334402
83	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.83801478
84	NANOG_19829295_ChIP-Seq_ESCs_Human	0.83735396
85	SOX2_19829295_ChIP-Seq_ESCs_Human	0.83735396
86	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.83569831
87	ERA_21632823_ChIP-Seq_H3396_Human	0.83480265
88	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.82602237
89	ER_23166858_ChIP-Seq_MCF-7_Human	0.82534811
90	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.81550477
91	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.81163753
92	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.80470044
93	CIITA_25753668_ChIP-Seq_RAJI_Human	0.79174441
94	SOX2_21211035_ChIP-Seq_LN229_Human	0.78907902
95	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.78314735
96	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.77754419
97	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.77362055
98	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.75529635
99	HOXB7_26014856_ChIP-Seq_BT474_Human	0.75419947
100	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.74408795

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.17208990
2	MP0009379_abnormal_foot_pigmentation	4.67947500
3	MP0003718_maternal_effect	4.65948570
4	MP0008789_abnormal_olfactory_epithelium	3.84847334
5	MP0005499_abnormal_olfactory_system	3.33411306
6	MP0005394_taste/olfaction_phenotype	3.33411306
7	MP0002138_abnormal_hepatobiliary_system	2.99625238
8	MP0008877_abnormal_DNA_methylation	2.84323644
9	MP0003693_abnormal_embryo_hatching	2.63715933
10	MP0004142_abnormal_muscle_tone	1.95063204
11	MP0005395_other_phenotype	1.94606830
12	MP0008058_abnormal_DNA_repair	1.91628163
13	MP0005645_abnormal_hypothalamus_physiol	1.87194586
14	MP0005646_abnormal_pituitary_gland	1.84684384
15	MP0002163_abnormal_gland_morphology	1.83780664
16	MP0002234_abnormal_pharynx_morphology	1.77360490
17	MP0002160_abnormal_reproductive_system	1.72466406
18	MP0010030_abnormal_orbit_morphology	1.71911710
19	MP0005389_reproductive_system_phenotype	1.69445177
20	MP0000569_abnormal_digit_pigmentation	1.61911636
21	MP0002210_abnormal_sex_determination	1.60219251
22	MP0005551_abnormal_eye_electrophysiolog	1.58796414
23	MP0003183_abnormal_peptide_metabolism	1.54929037
24	MP0003252_abnormal_bile_duct	1.54215794
25	MP0001293_anophthalmia	1.54001339
26	MP0005410_abnormal_fertilization	1.53782010
27	MP0001929_abnormal_gametogenesis	1.51610899
28	MP0005408_hypopigmentation	1.50298846
29	MP0005671_abnormal_response_to	1.50011744
30	MP0003890_abnormal_embryonic-extraembry	1.50006914
31	MP0001986_abnormal_taste_sensitivity	1.47522029
32	MP0003136_yellow_coat_color	1.46959192
33	MP0000631_abnormal_neuroendocrine_gland	1.46706429
34	MP0002095_abnormal_skin_pigmentation	1.37809677
35	MP0002638_abnormal_pupillary_reflex	1.37538907
36	MP0003186_abnormal_redox_activity	1.34148402
37	MP0000372_irregular_coat_pigmentation	1.34142026
38	MP0003646_muscle_fatigue	1.31652599
39	MP0008995_early_reproductive_senescence	1.30139377
40	MP0008875_abnormal_xenobiotic_pharmacok	1.29838047
41	MP0002277_abnormal_respiratory_mucosa	1.29719625
42	MP0001919_abnormal_reproductive_system	1.28626362
43	MP0009333_abnormal_splenocyte_physiolog	1.27981803
44	MP0000653_abnormal_sex_gland	1.26602716
45	MP0001984_abnormal_olfaction	1.26242298
46	MP0006276_abnormal_autonomic_nervous	1.26118229
47	MP0003699_abnormal_female_reproductive	1.25229293
48	MP0005174_abnormal_tail_pigmentation	1.25219772
49	MP0002837_dystrophic_cardiac_calcinosis	1.23298730
50	MP0000049_abnormal_middle_ear	1.18239962
51	MP0001905_abnormal_dopamine_level	1.16639927
52	MP0001873_stomach_inflammation	1.13610279
53	MP0001119_abnormal_female_reproductive	1.12435885
54	MP0005084_abnormal_gallbladder_morpholo	1.10351478
55	MP0002272_abnormal_nervous_system	1.09413998
56	MP0005360_urolithiasis	1.08719410
57	MP0001145_abnormal_male_reproductive	1.07067644
58	MP0000015_abnormal_ear_pigmentation	1.04696877
59	MP0000678_abnormal_parathyroid_gland	1.03655003
60	MP0004145_abnormal_muscle_electrophysio	1.02384393
61	MP0004147_increased_porphyrin_level	1.01232986
62	MP0002233_abnormal_nose_morphology	1.01125326
63	MP0003786_premature_aging	0.98349242
64	MP0003121_genomic_imprinting	0.96944131
65	MP0001968_abnormal_touch/_nociception	0.95296846
66	MP0003195_calcinosis	0.95140978
67	MP0003111_abnormal_nucleus_morphology	0.94338992
68	MP0002161_abnormal_fertility/fecundity	0.93344981
69	MP0005195_abnormal_posterior_eye	0.91702371
70	MP0002938_white_spotting	0.91287158
71	MP0003698_abnormal_male_reproductive	0.91163462
72	MP0003879_abnormal_hair_cell	0.90341566
73	MP0001188_hyperpigmentation	0.89043494
74	MP0008872_abnormal_physiological_respon	0.88385221
75	MP0001324_abnormal_eye_pigmentation	0.87847632
76	MP0002102_abnormal_ear_morphology	0.87145280
77	MP0003567_abnormal_fetal_cardiomyocyte	0.87031263
78	MP0005085_abnormal_gallbladder_physiolo	0.85188984
79	MP0005075_abnormal_melanosome_morpholog	0.84176550
80	MP0003936_abnormal_reproductive_system	0.81297788
81	MP0001485_abnormal_pinna_reflex	0.80957469
82	MP0003119_abnormal_digestive_system	0.78689232
83	MP0004957_abnormal_blastocyst_morpholog	0.78166026
84	MP0009745_abnormal_behavioral_response	0.77982800
85	MP0003938_abnormal_ear_development	0.77796061
86	MP0008932_abnormal_embryonic_tissue	0.76729740
87	MP0000566_synostosis	0.76382437
88	MP0005379_endocrine/exocrine_gland_phen	0.74078059
89	MP0002733_abnormal_thermal_nociception	0.74073330
90	MP0010094_abnormal_chromosome_stability	0.73365009
91	MP0006036_abnormal_mitochondrial_physio	0.72593360
92	MP0006072_abnormal_retinal_apoptosis	0.71490202
93	MP0005647_abnormal_sex_gland	0.69077046
94	MP0003878_abnormal_ear_physiology	0.67196524
95	MP0005377_hearing/vestibular/ear_phenot	0.67196524
96	MP0001666_abnormal_nutrient_absorption	0.65941983
97	MP0002736_abnormal_nociception_after	0.63471105
98	MP0002752_abnormal_somatic_nervous	0.63331663
99	MP0003880_abnormal_central_pattern	0.63103604
100	MP0001963_abnormal_hearing_physiology	0.61426146

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Supernumerary spleens (HP:0009799)	3.66828127
2	Acute necrotizing encephalopathy (HP:0006965)	3.61159317
3	Reticulocytopenia (HP:0001896)	3.49333456
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.37601404
5	Septo-optic dysplasia (HP:0100842)	3.31730978
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.24358185
7	Anterior segment dysgenesis (HP:0007700)	3.02679721
8	Acute encephalopathy (HP:0006846)	2.99163444
9	Pancreatic cysts (HP:0001737)	2.96807981
10	Progressive macrocephaly (HP:0004481)	2.96632309
11	Infertility (HP:0000789)	2.96333453
12	Mitochondrial inheritance (HP:0001427)	2.96183771
13	3-Methylglutaconic aciduria (HP:0003535)	2.95539075
14	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.93472465
15	Absent/shortened dynein arms (HP:0200106)	2.93472465
16	Methylmalonic acidemia (HP:0002912)	2.90863356
17	Absent thumb (HP:0009777)	2.90384778
18	Abnormal rod and cone electroretinograms (HP:0008323)	2.88043043
19	Pancreatic fibrosis (HP:0100732)	2.87474892
20	Abnormality of midbrain morphology (HP:0002418)	2.86430440
21	Molar tooth sign on MRI (HP:0002419)	2.86430440
22	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.83374737
23	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.81779106
24	Hypoplasia of the fovea (HP:0007750)	2.81779106
25	Abnormal respiratory epithelium morphology (HP:0012253)	2.80876899
26	Abnormal respiratory motile cilium morphology (HP:0005938)	2.80876899
27	Impulsivity (HP:0100710)	2.80807398
28	Renal Fanconi syndrome (HP:0001994)	2.80743045
29	Aplastic anemia (HP:0001915)	2.71660795
30	Macrocytic anemia (HP:0001972)	2.67584432
31	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.64660902
32	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.64660902
33	Abnormal ciliary motility (HP:0012262)	2.63268001
34	Increased CSF lactate (HP:0002490)	2.59859433
35	Increased hepatocellular lipid droplets (HP:0006565)	2.56864440
36	Abnormal respiratory motile cilium physiology (HP:0012261)	2.56050792
37	Bile duct proliferation (HP:0001408)	2.55733677
38	Abnormal biliary tract physiology (HP:0012439)	2.55733677
39	Pendular nystagmus (HP:0012043)	2.54641376
40	Abnormality of cells of the erythroid lineage (HP:0012130)	2.53387085
41	Abnormality of DNA repair (HP:0003254)	2.52551728
42	True hermaphroditism (HP:0010459)	2.48600152
43	Male infertility (HP:0003251)	2.47323204
44	Generalized aminoaciduria (HP:0002909)	2.45179505
45	Colon cancer (HP:0003003)	2.44555999
46	Nephronophthisis (HP:0000090)	2.38989215
47	Dry hair (HP:0011359)	2.35171419
48	Hypoproteinemia (HP:0003075)	2.31069902
49	Lipid accumulation in hepatocytes (HP:0006561)	2.28310984
50	Hypophosphatemic rickets (HP:0004912)	2.26362286
51	Increased intramyocellular lipid droplets (HP:0012240)	2.24169120
52	Congenital stationary night blindness (HP:0007642)	2.23158567
53	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.21319677
54	Myokymia (HP:0002411)	2.20517785
55	Abnormality of the fovea (HP:0000493)	2.18874142
56	Oligodactyly (hands) (HP:0001180)	2.16976737
57	Type II lissencephaly (HP:0007260)	2.16212631
58	Osteomalacia (HP:0002749)	2.16037601
59	Renal cortical cysts (HP:0000803)	2.15933297
60	Cerebral edema (HP:0002181)	2.14649019
61	Methylmalonic aciduria (HP:0012120)	2.14621112
62	Abnormality of the renal cortex (HP:0011035)	2.14411957
63	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.09834632
64	Cleft eyelid (HP:0000625)	2.09147903
65	Medial flaring of the eyebrow (HP:0010747)	2.06583388
66	Abnormality of the renal medulla (HP:0100957)	2.05769631
67	Aplasia/Hypoplasia of the macula (HP:0008059)	2.03986808
68	Abnormality of the ileum (HP:0001549)	2.03887981
69	Abnormal number of erythroid precursors (HP:0012131)	2.03549344
70	Optic disc pallor (HP:0000543)	2.03106467
71	Oligodactyly (HP:0012165)	1.99669250
72	Severe visual impairment (HP:0001141)	1.99570383
73	Attenuation of retinal blood vessels (HP:0007843)	1.99549977
74	Rhinitis (HP:0012384)	1.99331594
75	Abnormality of renal resorption (HP:0011038)	1.98498447
76	Anencephaly (HP:0002323)	1.98453250
77	Nausea (HP:0002018)	1.98002619
78	Pancytopenia (HP:0001876)	1.96111911
79	Abnormality of urine glucose concentration (HP:0011016)	1.95646647
80	Glycosuria (HP:0003076)	1.95646647
81	Absent septum pellucidum (HP:0001331)	1.93927891
82	Azoospermia (HP:0000027)	1.92792546
83	Asplenia (HP:0001746)	1.92657517
84	Decreased central vision (HP:0007663)	1.91770728
85	Triphalangeal thumb (HP:0001199)	1.91458691
86	Esophageal atresia (HP:0002032)	1.90975844
87	Hepatic necrosis (HP:0002605)	1.90423477
88	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.89455640
89	Tubular atrophy (HP:0000092)	1.88895549
90	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.87743630
91	Meckel diverticulum (HP:0002245)	1.86083647
92	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.86069180
93	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.86069180
94	Testicular atrophy (HP:0000029)	1.84966843
95	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.84175983
96	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.83340074
97	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.82703900
98	Polydipsia (HP:0001959)	1.81102715
99	Abnormal drinking behavior (HP:0030082)	1.81102715
100	Exercise intolerance (HP:0003546)	1.79932028

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K13	3.51579806
2	MAP3K9	3.38402395
3	TXK	3.02171384
4	TAOK3	2.67501671
5	BCKDK	2.57575519
6	CDC7	2.23639498
7	NME2	2.12078223
8	EIF2AK3	2.03808188
9	ARAF	1.97028578
10	TIE1	1.85290431
11	STK24	1.78493863
12	CDK19	1.78475035
13	GRK1	1.77325776
14	WNK4	1.75438137
15	NUAK1	1.73419059
16	AURKA	1.73163281
17	MST4	1.65888369
18	ZAK	1.64313329
19	ADRBK2	1.61662763
20	NME1	1.57265277
21	TLK1	1.53502242
22	LRRK2	1.51330965
23	CAMKK2	1.45786182
24	NEK6	1.40003203
25	KDR	1.37207955
26	DMPK	1.36621285
27	BRAF	1.34771757
28	TYRO3	1.34275458
29	STK39	1.34033015
30	MAP4K1	1.31978302
31	PLK1	1.28307264
32	PINK1	1.23199350
33	NTRK2	1.14625086
34	DYRK2	1.09095792
35	BRSK2	1.08868496
36	BUB1	1.08348066
37	BMPR1B	1.06986789
38	ATR	1.02452037
39	ITK	1.02275723
40	IKBKB	0.99823191
41	BRSK1	0.99210005
42	OXSR1	0.96552965
43	PRKCI	0.92954378
44	PRKCQ	0.87925118
45	TEC	0.82496210
46	TTK	0.80325018
47	FRK	0.79486552
48	CAMK1	0.79277074
49	MAPKAPK3	0.77476517
50	STK3	0.74942123
51	MOS	0.74924073
52	VRK2	0.74361205
53	CDK7	0.73807448
54	MAP3K12	0.73737102
55	STK16	0.73666954
56	LIMK1	0.73278605
57	EIF2AK1	0.72525725
58	PIK3CA	0.70954350
59	PRKACA	0.68480623
60	PRKCG	0.68066213
61	PDK2	0.68025797
62	PLK3	0.67977585
63	PIM1	0.67288631
64	PIK3CG	0.66578960
65	TNK2	0.66361208
66	WNK3	0.66353367
67	ADRBK1	0.65048245
68	INSRR	0.64774410
69	MAP3K7	0.64512247
70	TRIM28	0.64318742
71	RAF1	0.62797516
72	ATM	0.61203247
73	CSNK2A2	0.60461396
74	MAP3K11	0.60203192
75	WNK1	0.59776534
76	VRK1	0.58294141
77	CDK9	0.56536771
78	SRPK1	0.56519911
79	PAK1	0.55282075
80	CHEK2	0.55268771
81	MAPK13	0.54211644
82	AURKB	0.53857159
83	STK4	0.53348297
84	CHEK1	0.51877983
85	MAP3K8	0.51165303
86	TNIK	0.50910610
87	SYK	0.47951806
88	CSNK2A1	0.47932879
89	PRKG1	0.47208286
90	PRKCZ	0.46981713
91	CAMK2A	0.46136044
92	BTK	0.46062903
93	CDK2	0.44459927
94	IKBKE	0.44309632
95	CSNK1E	0.44280421
96	PRKCE	0.43855909
97	CSNK1G1	0.41614056
98	CSNK1G3	0.40417415
99	MAP4K2	0.39439411
100	PLK4	0.39196043

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.18430146
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.66350707
3	Parkinsons disease_Homo sapiens_hsa05012	3.19814281
4	RNA polymerase_Homo sapiens_hsa03020	3.09308823
5	Proteasome_Homo sapiens_hsa03050	3.04602409
6	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.61603785
7	Mismatch repair_Homo sapiens_hsa03430	2.44195270
8	Homologous recombination_Homo sapiens_hsa03440	2.43206322
9	Huntingtons disease_Homo sapiens_hsa05016	2.39642411
10	Nucleotide excision repair_Homo sapiens_hsa03420	2.36500886
11	Protein export_Homo sapiens_hsa03060	2.36062740
12	Basal transcription factors_Homo sapiens_hsa03022	2.22834107
13	Phototransduction_Homo sapiens_hsa04744	2.12422230
14	RNA degradation_Homo sapiens_hsa03018	2.10283974
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.02733199
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.98472219
17	Base excision repair_Homo sapiens_hsa03410	1.95579545
18	DNA replication_Homo sapiens_hsa03030	1.92465650
19	Alzheimers disease_Homo sapiens_hsa05010	1.84978175
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.78930955
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.71499513
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.61827291
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.60749619
24	Primary immunodeficiency_Homo sapiens_hsa05340	1.58160213
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.58079126
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.50675466
27	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.48315915
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.44452137
29	RNA transport_Homo sapiens_hsa03013	1.36480177
30	Olfactory transduction_Homo sapiens_hsa04740	1.35945531
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.29565643
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.26239392
33	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.24168518
34	Propanoate metabolism_Homo sapiens_hsa00640	1.24034908
35	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.19369970
36	Purine metabolism_Homo sapiens_hsa00230	1.12436769
37	Asthma_Homo sapiens_hsa05310	1.11455019
38	One carbon pool by folate_Homo sapiens_hsa00670	1.05000105
39	Allograft rejection_Homo sapiens_hsa05330	1.02776593
40	Cell cycle_Homo sapiens_hsa04110	0.92774715
41	Caffeine metabolism_Homo sapiens_hsa00232	0.88688166
42	Ether lipid metabolism_Homo sapiens_hsa00565	0.87879875
43	Folate biosynthesis_Homo sapiens_hsa00790	0.86937728
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.86460550
45	Spliceosome_Homo sapiens_hsa03040	0.85380172
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.81542292
47	Oocyte meiosis_Homo sapiens_hsa04114	0.79987956
48	Morphine addiction_Homo sapiens_hsa05032	0.72285418
49	Graft-versus-host disease_Homo sapiens_hsa05332	0.71956284
50	Butanoate metabolism_Homo sapiens_hsa00650	0.70295846
51	Regulation of autophagy_Homo sapiens_hsa04140	0.68732063
52	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.67460395
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67170882
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.64733638
55	Metabolic pathways_Homo sapiens_hsa01100	0.62975670
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62247322
57	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.61613044
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.61123539
59	Peroxisome_Homo sapiens_hsa04146	0.58696595
60	Steroid biosynthesis_Homo sapiens_hsa00100	0.57076910
61	Nicotine addiction_Homo sapiens_hsa05033	0.55414818
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.54912947
63	Fatty acid elongation_Homo sapiens_hsa00062	0.54307327
64	Pyruvate metabolism_Homo sapiens_hsa00620	0.50744740
65	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49675292
66	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.49331034
67	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.48953826
68	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47983420
69	Rheumatoid arthritis_Homo sapiens_hsa05323	0.47021160
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43621158
71	Taste transduction_Homo sapiens_hsa04742	0.42479227
72	Nitrogen metabolism_Homo sapiens_hsa00910	0.41750182
73	Arginine and proline metabolism_Homo sapiens_hsa00330	0.40973806
74	Type I diabetes mellitus_Homo sapiens_hsa04940	0.40092072
75	Non-homologous end-joining_Homo sapiens_hsa03450	0.39763193
76	Serotonergic synapse_Homo sapiens_hsa04726	0.38927352
77	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38842313
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38537395
79	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.37803010
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36875627
81	Antigen processing and presentation_Homo sapiens_hsa04612	0.36781040
82	GABAergic synapse_Homo sapiens_hsa04727	0.34387707
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.31687297
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.31616768
85	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.30705877
86	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.29173411
87	Circadian entrainment_Homo sapiens_hsa04713	0.28087166
88	Retinol metabolism_Homo sapiens_hsa00830	0.27664232
89	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.27582699
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.27503180
91	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.26219477
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.25954857
93	Sulfur metabolism_Homo sapiens_hsa00920	0.25733489
94	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.25620716
95	Chemical carcinogenesis_Homo sapiens_hsa05204	0.24994149
96	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.24846643
97	Sulfur relay system_Homo sapiens_hsa04122	0.23211012
98	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.23086148
99	p53 signaling pathway_Homo sapiens_hsa04115	0.22406834
100	Circadian rhythm_Homo sapiens_hsa04710	0.22298233

RPL19P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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