ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of muscle hypertrophy (GO:0014741)	9.61229314
2	skeletal muscle tissue regeneration (GO:0043403)	8.53384212
3	actin-mediated cell contraction (GO:0070252)	8.42744943
4	response to muscle activity (GO:0014850)	8.30813111
5	regulation of skeletal muscle contraction (GO:0014819)	8.28062569
6	negative regulation of skeletal muscle tissue development (GO:0048642)	7.86435269
7	actin filament-based movement (GO:0030048)	5.89458834
8	cellular response to dexamethasone stimulus (GO:0071549)	5.65983137
9	response to activity (GO:0014823)	5.59659495
10	embryonic skeletal joint morphogenesis (GO:0060272)	5.45800939
11	skeletal muscle contraction (GO:0003009)	5.38431318
12	protein K6-linked ubiquitination (GO:0085020)	5.38118212
13	response to dexamethasone (GO:0071548)	5.22330890
14	cullin deneddylation (GO:0010388)	5.15505206
15	striated muscle adaptation (GO:0014888)	4.99905555
16	protein deneddylation (GO:0000338)	4.72470514
17	negative regulation of organelle assembly (GO:1902116)	4.62226422
18	maturation of SSU-rRNA (GO:0030490)	4.37206582
19	regulation of relaxation of muscle (GO:1901077)	4.23684092
20	muscle adaptation (GO:0043500)	4.21707718
21	muscle organ development (GO:0007517)	4.20574041
22	muscle structure development (GO:0061061)	4.15147884
23	muscle cell cellular homeostasis (GO:0046716)	3.91953466
24	regulation of muscle hypertrophy (GO:0014743)	3.87976769
25	protein polyglutamylation (GO:0018095)	3.77227108
26	negative regulation of histone acetylation (GO:0035067)	3.75320648
27	response to electrical stimulus (GO:0051602)	3.63588020
28	myotube cell development (GO:0014904)	3.62557848
29	negative regulation of fatty acid biosynthetic process (GO:0045717)	3.60839593
30	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.51442446
31	organ induction (GO:0001759)	3.50238737
32	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.48147623
33	response to folic acid (GO:0051593)	3.47238482
34	myoblast fusion (GO:0007520)	3.39310051
35	striated muscle contraction (GO:0006941)	3.34593766
36	dosage compensation (GO:0007549)	3.32759179
37	protein trimerization (GO:0070206)	3.30106285
38	muscle system process (GO:0003012)	3.29644560
39	response to testosterone (GO:0033574)	3.28611592
40	muscle contraction (GO:0006936)	3.24530498
41	negative regulation of peptidyl-lysine acetylation (GO:2000757)	3.23972432
42	response to inactivity (GO:0014854)	3.23188338
43	regulation of centriole replication (GO:0046599)	3.19589437
44	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	3.19033129
45	negative regulation of striated muscle tissue development (GO:0045843)	3.18526086
46	regulation of sarcomere organization (GO:0060297)	3.15793609
47	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.15574249
48	tissue regeneration (GO:0042246)	3.14205014
49	postsynaptic membrane organization (GO:0001941)	3.10424301
50	negative regulation of muscle tissue development (GO:1901862)	3.06889052
51	skeletal muscle fiber development (GO:0048741)	3.02175841
52	regulation of DNA methylation (GO:0044030)	2.97734549
53	negative regulation of muscle organ development (GO:0048635)	2.95576518
54	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.92969274
55	DNA damage response, signal transduction resulting in transcription (GO:0042772)	2.90853179
56	regulation of striated muscle contraction (GO:0006942)	2.84760763
57	neuronal action potential propagation (GO:0019227)	2.84682224
58	positive regulation of histone H3-K4 methylation (GO:0051571)	2.82794455
59	cellular response to glucocorticoid stimulus (GO:0071385)	2.80425364
60	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	2.80186493
61	outer ear morphogenesis (GO:0042473)	2.79632239
62	proximal/distal pattern formation (GO:0009954)	2.78178075
63	ketone body metabolic process (GO:1902224)	2.76091242
64	syncytium formation by plasma membrane fusion (GO:0000768)	2.75332124
65	protein-cofactor linkage (GO:0018065)	2.70420012
66	negative regulation of protein acetylation (GO:1901984)	2.69865138
67	sarcoplasmic reticulum calcium ion transport (GO:0070296)	2.68381687
68	cGMP-mediated signaling (GO:0019934)	2.65672722
69	lipopolysaccharide biosynthetic process (GO:0009103)	2.62798896
70	lysine metabolic process (GO:0006553)	2.61380614
71	lysine catabolic process (GO:0006554)	2.61380614
72	metanephros development (GO:0001656)	2.60364745
73	cellular response to corticosteroid stimulus (GO:0071384)	2.58250389
74	plasma membrane fusion (GO:0045026)	2.56347553
75	cellular ketone body metabolic process (GO:0046950)	2.54390481
76	developmental induction (GO:0031128)	2.52312826
77	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.51590081
78	syncytium formation (GO:0006949)	2.51421635
79	skeletal muscle tissue development (GO:0007519)	2.47362104
80	lung secretory cell differentiation (GO:0061140)	2.44127932
81	cellular response to ketone (GO:1901655)	2.43442655
82	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	2.42838180
83	cell-cell signaling involved in cell fate commitment (GO:0045168)	2.40810253
84	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	2.39336377
85	regulation of muscle system process (GO:0090257)	2.38358550
86	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.38037743
87	retinal cone cell development (GO:0046549)	2.37986324
88	positive regulation of chondrocyte differentiation (GO:0032332)	2.37560894
89	appendage development (GO:0048736)	2.36644377
90	limb development (GO:0060173)	2.36644377
91	regulation of histone H3-K9 methylation (GO:0051570)	2.36627321
92	behavioral response to nicotine (GO:0035095)	2.34932051
93	negative regulation of fatty acid metabolic process (GO:0045922)	2.31661513
94	sarcomere organization (GO:0045214)	2.26394984
95	response to gravity (GO:0009629)	12.4313345
96	striated muscle atrophy (GO:0014891)	11.5895784
97	skeletal muscle adaptation (GO:0043501)	11.3285695
98	muscle atrophy (GO:0014889)	10.6269586
99	actin-myosin filament sliding (GO:0033275)	10.2097817
100	muscle filament sliding (GO:0030049)	10.2097817

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	7.16220341
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	5.38106924
3	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	4.98934337
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.11714724
5	TAF15_26573619_Chip-Seq_HEK293_Human	3.84633979
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.55558502
7	FUS_26573619_Chip-Seq_HEK293_Human	2.90867582
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.71389349
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.67964610
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.47701789
11	AR_21572438_ChIP-Seq_LNCaP_Human	2.47633054
12	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.44237406
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.29901056
14	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.20009482
15	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.04274145
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.04183409
17	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.00263550
18	GATA1_22025678_ChIP-Seq_K562_Human	1.97650225
19	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.93048686
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.90843294
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.88553969
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.82064989
23	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.78701085
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.77688913
25	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.75790038
26	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.70555080
27	GBX2_23144817_ChIP-Seq_PC3_Human	1.65615512
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.63884179
29	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.63039864
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.59038344
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58699373
32	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.56901053
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55124333
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.54614129
35	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.54232089
36	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.49739068
37	P300_19829295_ChIP-Seq_ESCs_Human	1.49459721
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48312976
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46183444
40	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.46183444
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.46147863
42	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.44941436
43	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.39858950
44	ZNF274_21170338_ChIP-Seq_K562_Hela	1.39300498
45	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.38063642
46	KDM2B_26808549_Chip-Seq_REH_Human	1.35943359
47	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.29065963
48	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.27230003
49	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.26512330
50	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.26283595
51	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.23875221
52	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.23567721
53	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.21758311
54	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.21388774
55	IGF1R_20145208_ChIP-Seq_DFB_Human	1.17252379
56	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16111357
57	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.13346841
58	SOX9_26525672_Chip-Seq_HEART_Mouse	1.10725855
59	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.09913959
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07576841
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.07355870
62	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.06913345
63	STAT3_23295773_ChIP-Seq_U87_Human	1.06176131
64	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.04060547
65	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.02516601
66	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.01193171
67	EWS_26573619_Chip-Seq_HEK293_Human	1.00626105
68	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.99549665
69	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.99316206
70	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.97346857
71	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.97205902
72	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.96046313
73	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.95938746
74	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.93780138
75	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.92733973
76	MYC_19829295_ChIP-Seq_ESCs_Human	0.91752627
77	ELK1_19687146_ChIP-ChIP_HELA_Human	0.91274983
78	DCP1A_22483619_ChIP-Seq_HELA_Human	0.91067081
79	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.90713995
80	TCF4_23295773_ChIP-Seq_U87_Human	0.90382025
81	AR_20517297_ChIP-Seq_VCAP_Human	0.88898238
82	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.87664026
83	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.86815072
84	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.85992898
85	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.85027453
86	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.84742143
87	RXR_22108803_ChIP-Seq_LS180_Human	0.84304845
88	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.83639179
89	FOXP3_21729870_ChIP-Seq_TREG_Human	0.82763706
90	BCAT_22108803_ChIP-Seq_LS180_Human	0.81963899
91	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.81873252
92	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.81347017
93	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	0.81223186
94	CBP_20019798_ChIP-Seq_JUKART_Human	0.81167238
95	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.81167238
96	CEBPB_22108803_ChIP-Seq_LS180_Human	0.80539283
97	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.78863178
98	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.78326940
99	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.78326940
100	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.77476879

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000749_muscle_degeneration	4.88531709
2	MP0000747_muscle_weakness	4.66909430
3	MP0004145_abnormal_muscle_electrophysio	4.49941018
4	MP0004036_abnormal_muscle_relaxation	3.68278813
5	MP0002269_muscular_atrophy	3.38720013
6	MP0002638_abnormal_pupillary_reflex	3.19111615
7	MP0003705_abnormal_hypodermis_morpholog	2.98812073
8	MP0000759_abnormal_skeletal_muscle	2.93020255
9	MP0000372_irregular_coat_pigmentation	2.91155777
10	MP0002089_abnormal_postnatal_growth/wei	2.88762883
11	MP0004270_analgesia	2.57267714
12	MP0002108_abnormal_muscle_morphology	2.47492010
13	MP0003950_abnormal_plasma_membrane	2.46905146
14	MP0002095_abnormal_skin_pigmentation	2.46606945
15	MP0005620_abnormal_muscle_contractility	2.43494321
16	MP0000751_myopathy	2.32096491
17	MP0003123_paternal_imprinting	2.28247464
18	MP0004087_abnormal_muscle_fiber	2.26559258
19	MP0005171_absent_coat_pigmentation	2.22696253
20	MP0002106_abnormal_muscle_physiology	2.09329975
21	MP0005083_abnormal_biliary_tract	2.09178250
22	MP0004084_abnormal_cardiac_muscle	2.06224536
23	MP0003880_abnormal_central_pattern	2.04947882
24	MP0003122_maternal_imprinting	1.84273664
25	MP0000733_abnormal_muscle_development	1.81265684
26	MP0005369_muscle_phenotype	1.72573237
27	MP0002736_abnormal_nociception_after	1.69710063
28	MP0005408_hypopigmentation	1.66328520
29	MP0003937_abnormal_limbs/digits/tail_de	1.55518635
30	MP0000427_abnormal_hair_cycle	1.54262226
31	MP0000566_synostosis	1.52560628
32	MP0003646_muscle_fatigue	1.50742447
33	MP0004147_increased_porphyrin_level	1.50742140
34	MP0003136_yellow_coat_color	1.47638364
35	MP0002102_abnormal_ear_morphology	1.47251281
36	MP0009250_abnormal_appendicular_skeleto	1.40190391
37	MP0004484_altered_response_of	1.35602046
38	MP0003011_delayed_dark_adaptation	1.35330164
39	MP0010030_abnormal_orbit_morphology	1.31842351
40	MP0009697_abnormal_copulation	1.28931881
41	MP0000750_abnormal_muscle_regeneration	1.22455412
42	MP0003385_abnormal_body_wall	1.20379025
43	MP0001968_abnormal_touch/_nociception	1.19642686
44	MP0005075_abnormal_melanosome_morpholog	1.16609198
45	MP0000049_abnormal_middle_ear	1.15024814
46	MP0004215_abnormal_myocardial_fiber	1.13404643
47	MP0001661_extended_life_span	1.12488382
48	MP0003959_abnormal_lean_body	1.09961458
49	MP0009780_abnormal_chondrocyte_physiolo	1.09612443
50	MP0003755_abnormal_palate_morphology	1.05860995
51	MP0000467_abnormal_esophagus_morphology	1.03653320
52	MP0005423_abnormal_somatic_nervous	1.02845541
53	MP0002896_abnormal_bone_mineralization	1.00485629
54	MP0005253_abnormal_eye_physiology	1.00475157
55	MP0000579_abnormal_nail_morphology	0.92366983
56	MP0008789_abnormal_olfactory_epithelium	0.91992532
57	MP0004133_heterotaxia	0.90563971
58	MP0002177_abnormal_outer_ear	0.90476071
59	MP0002114_abnormal_axial_skeleton	0.89899136
60	MP0002938_white_spotting	0.88764222
61	MP0003878_abnormal_ear_physiology	0.88278460
62	MP0005377_hearing/vestibular/ear_phenot	0.88278460
63	MP0000569_abnormal_digit_pigmentation	0.87233267
64	MP0005248_abnormal_Harderian_gland	0.81919028
65	MP0010234_abnormal_vibrissa_follicle	0.81812535
66	MP0010307_abnormal_tumor_latency	0.81665050
67	MP0003121_genomic_imprinting	0.81326305
68	MP0006072_abnormal_retinal_apoptosis	0.80179284
69	MP0002075_abnormal_coat/hair_pigmentati	0.79591792
70	MP0002127_abnormal_cardiovascular_syste	0.79333774
71	MP0005174_abnormal_tail_pigmentation	0.79207895
72	MP0002822_catalepsy	0.78151158
73	MP0004043_abnormal_pH_regulation	0.76661201
74	MP0000778_abnormal_nervous_system	0.76259270
75	MP0003942_abnormal_urinary_system	0.75407421
76	MP0002734_abnormal_mechanical_nocicepti	0.75243238
77	MP0001243_abnormal_dermal_layer	0.74266767
78	MP0002109_abnormal_limb_morphology	0.74165331
79	MP0000015_abnormal_ear_pigmentation	0.73851592
80	MP0002115_abnormal_skeleton_extremities	0.70182073
81	MP0000631_abnormal_neuroendocrine_gland	0.68790119
82	MP0001293_anophthalmia	0.68765416
83	MP0003941_abnormal_skin_development	0.68600952
84	MP0005275_abnormal_skin_tensile	0.68397724
85	MP0000534_abnormal_ureter_morphology	0.68309232
86	MP0001529_abnormal_vocalization	0.66555074
87	MP0002233_abnormal_nose_morphology	0.66109013
88	MP0003045_fibrosis	0.65553326
89	MP0005551_abnormal_eye_electrophysiolog	0.65125788
90	MP0005646_abnormal_pituitary_gland	0.64475474
91	MP0001984_abnormal_olfaction	0.61865668
92	MP0002116_abnormal_craniofacial_bone	0.61682486
93	MP0000377_abnormal_hair_follicle	0.60755375
94	MP0003786_premature_aging	0.59991160
95	MP0001502_abnormal_circadian_rhythm	0.59592207
96	MP0002972_abnormal_cardiac_muscle	0.59362192
97	MP0002277_abnormal_respiratory_mucosa	0.58509216
98	MP0000537_abnormal_urethra_morphology	0.58038418
99	MP0002249_abnormal_larynx_morphology	0.57983600
100	MP0000371_diluted_coat_color	0.55093008

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Distal arthrogryposis (HP:0005684)	7.20648446
2	Palpebral edema (HP:0100540)	6.58839310
3	Absent phalangeal crease (HP:0006109)	6.51506123
4	Ulnar deviation of the wrist (HP:0003049)	6.50269751
5	Deformed tarsal bones (HP:0008119)	6.23799413
6	Nemaline bodies (HP:0003798)	6.10848012
7	Round ear (HP:0100830)	5.94061368
8	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	5.53865344
9	Exercise-induced myalgia (HP:0003738)	5.53019006
10	Calcaneovalgus deformity (HP:0001848)	5.49908748
11	Abnormal finger flexion creases (HP:0006143)	5.44124470
12	Muscle fiber inclusion bodies (HP:0100299)	5.43865327
13	Mask-like facies (HP:0000298)	5.04967202
14	Exercise-induced muscle cramps (HP:0003710)	4.56174684
15	Type 2 muscle fiber atrophy (HP:0003554)	4.47901423
16	Muscle fiber atrophy (HP:0100295)	4.00017384
17	Hyperkalemia (HP:0002153)	3.97143143
18	Type 1 muscle fiber predominance (HP:0003803)	3.71424501
19	Fibular aplasia (HP:0002990)	3.53598445
20	Popliteal pterygium (HP:0009756)	3.42164169
21	Malignant hyperthermia (HP:0002047)	3.33059421
22	Myopathic facies (HP:0002058)	3.16156142
23	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.07127860
24	Abnormality of the neuromuscular junction (HP:0003398)	3.05594179
25	Fatigable weakness (HP:0003473)	3.05594179
26	Periorbital edema (HP:0100539)	3.00643455
27	Myotonia (HP:0002486)	2.98939887
28	Weak cry (HP:0001612)	2.92525488
29	Myoglobinuria (HP:0002913)	2.86967433
30	Facial edema (HP:0000282)	2.83655207
31	Nonprogressive disorder (HP:0003680)	2.83345749
32	Abnormality of the calcaneus (HP:0008364)	2.78336147
33	Muscle hypertrophy of the lower extremities (HP:0008968)	2.67781387
34	Down-sloping shoulders (HP:0200021)	2.62360265
35	Adactyly (HP:0009776)	2.54171424
36	Mesomelia (HP:0003027)	2.50896189
37	Abnormality of placental membranes (HP:0011409)	2.35453366
38	Amniotic constriction ring (HP:0009775)	2.35453366
39	Microglossia (HP:0000171)	2.30473707
40	Gowers sign (HP:0003391)	2.26854585
41	Neoplasm of the heart (HP:0100544)	2.26646532
42	Rectal prolapse (HP:0002035)	2.22045754
43	Metatarsus adductus (HP:0001840)	2.21552593
44	Muscle stiffness (HP:0003552)	2.20116825
45	Abnormality of potassium homeostasis (HP:0011042)	2.16424223
46	Increased connective tissue (HP:0009025)	2.07827750
47	Hyporeflexia of lower limbs (HP:0002600)	2.03031357
48	Abnormality of alanine metabolism (HP:0010916)	1.98232751
49	Hyperalaninemia (HP:0003348)	1.98232751
50	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.98232751
51	Aplasia of the musculature (HP:0100854)	1.97350174
52	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.96228497
53	Abnormality of the 2nd finger (HP:0004100)	1.93829102
54	Coronal craniosynostosis (HP:0004440)	1.92715575
55	2-3 toe syndactyly (HP:0004691)	1.92190420
56	Synostosis involving bones of the feet (HP:0009140)	1.90102179
57	Synostosis involving bones of the lower limbs (HP:0009138)	1.90102179
58	3-Methylglutaconic aciduria (HP:0003535)	1.90067318
59	Calf muscle hypertrophy (HP:0008981)	1.86711027
60	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.85118570
61	Tarsal synostosis (HP:0008368)	1.82475355
62	Methylmalonic acidemia (HP:0002912)	1.82396644
63	Rhabdomyolysis (HP:0003201)	1.81945916
64	Delayed CNS myelination (HP:0002188)	1.81691254
65	Hyperglycinemia (HP:0002154)	1.81428118
66	Abnormal mitochondria in muscle tissue (HP:0008316)	1.77270076
67	Neonatal respiratory distress (HP:0002643)	1.76791504
68	Methylmalonic aciduria (HP:0012120)	1.75389360
69	Abnormality of the calf musculature (HP:0001430)	1.74423931
70	Ulnar deviation of finger (HP:0009465)	1.74263705
71	Easy fatigability (HP:0003388)	1.73288578
72	Acute necrotizing encephalopathy (HP:0006965)	1.70616778
73	Difficulty running (HP:0009046)	1.67894756
74	Reduced subcutaneous adipose tissue (HP:0003758)	1.64907573
75	Neck muscle weakness (HP:0000467)	1.64555637
76	Decreased circulating renin level (HP:0003351)	1.64207227
77	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.61469990
78	Cerebral hypomyelination (HP:0006808)	1.61246161
79	Progressive macrocephaly (HP:0004481)	1.60674933
80	Hepatocellular necrosis (HP:0001404)	1.60599113
81	Short tibia (HP:0005736)	1.60116890
82	Webbed neck (HP:0000465)	1.58416059
83	Poor suck (HP:0002033)	1.58145122
84	Unsteady gait (HP:0002317)	1.58021921
85	Short phalanx of the thumb (HP:0009660)	1.54618253
86	Pterygium (HP:0001059)	1.52885551
87	Broad hallux (HP:0010055)	1.52189732
88	Asplenia (HP:0001746)	1.51876314
89	Abnormal number of incisors (HP:0011064)	1.51714109
90	Acute encephalopathy (HP:0006846)	1.49880344
91	Adducted thumb (HP:0001181)	1.49519541
92	Ulnar deviation of the hand or of fingers of the hand (HP:0001193)	1.49423741
93	Increased CSF lactate (HP:0002490)	1.49044191
94	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.48969166
95	Fetal akinesia sequence (HP:0001989)	1.48899147
96	Hepatic necrosis (HP:0002605)	1.46507205
97	Congenital stationary night blindness (HP:0007642)	1.45987505
98	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.45687829
99	Mitochondrial inheritance (HP:0001427)	1.44788732
100	Generalized muscle weakness (HP:0003324)	1.42863781

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	5.49123908
2	OBSCN	4.13040076
3	MAP4K2	3.74237521
4	MUSK	3.69026406
5	PHKG1	3.54281747
6	PHKG2	3.54281747
7	TIE1	3.24033605
8	WNK4	2.73662480
9	PBK	2.64629116
10	CCNB1	2.39263740
11	MAPK13	2.25824656
12	ARAF	2.07310316
13	NUAK1	1.94247945
14	CAMK1D	1.92343395
15	CAMK1G	1.84775941
16	STK16	1.80179410
17	LIMK1	1.79554107
18	WNK1	1.64550154
19	PIK3CG	1.62805314
20	EIF2AK1	1.62725309
21	SRPK1	1.61290150
22	PRKD3	1.53625830
23	DYRK2	1.51968794
24	CDK19	1.51711550
25	IRAK1	1.51158212
26	EIF2AK3	1.48144459
27	NEK1	1.33669857
28	PIK3CA	1.24214846
29	BCKDK	1.21917269
30	MKNK2	1.21308579
31	CAMKK2	1.20232216
32	TAOK3	1.14174857
33	CHEK2	1.14003632
34	TAF1	1.12861067
35	JAK3	1.10803645
36	BMPR1B	1.10383395
37	STK39	1.06813607
38	FRK	0.96027129
39	MARK3	0.94748706
40	CDK4	0.94713619
41	CAMK2G	0.92258505
42	MAPK7	0.86079453
43	CSNK1G1	0.85722342
44	MKNK1	0.85024883
45	MAP2K4	0.84945849
46	PRKG2	0.84890213
47	CASK	0.81303347
48	AURKA	0.77321875
49	RAF1	0.76291240
50	PINK1	0.76109975
51	EPHA4	0.73857241
52	MAP2K7	0.73436181
53	CSNK1A1L	0.72702914
54	CSNK1G2	0.71008280
55	VRK1	0.67558570
56	BUB1	0.67374353
57	CSNK1G3	0.63261676
58	EIF2AK2	0.61629038
59	TYRO3	0.58567307
60	PTK2B	0.56723281
61	DYRK1B	0.56711687
62	PRKG1	0.56570167
63	PIM2	0.56293394
64	VRK2	0.55656969
65	OXSR1	0.55554718
66	BRAF	0.54803262
67	WNK3	0.54481573
68	MAPK12	0.51182030
69	AKT2	0.48672008
70	MOS	0.48362871
71	ZAK	0.47545693
72	ILK	0.45105955
73	MAP3K4	0.39395184
74	CAMK1	0.38607301
75	NEK9	0.37023956
76	PNCK	0.36626551
77	DMPK	0.36197820
78	ATR	0.34533448
79	LRRK2	0.31622622
80	PKN1	0.31552456
81	MAP3K10	0.31176934
82	GRK1	0.30437946
83	NME2	0.27696748
84	CAMKK1	0.27318614
85	DYRK3	0.25806519
86	PRKACA	0.24659300
87	IRAK2	0.23759033
88	CSNK2A1	0.22128673
89	SGK1	0.21974352
90	RPS6KA5	0.21419871
91	NTRK2	0.20838090
92	NEK6	0.20417008
93	PRKCE	0.20110285
94	ADRBK2	0.19055817
95	INSRR	0.18523292
96	FGFR2	0.18383935
97	PLK1	0.18330458
98	TTK	0.17681578
99	CDK5	0.15427349
100	ATM	0.15205252

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.78836452
2	Tight junction_Homo sapiens_hsa04530	3.56668470
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.76875183
4	Regulation of autophagy_Homo sapiens_hsa04140	2.68497826
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.19446780
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.11287767
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.04152828
8	Parkinsons disease_Homo sapiens_hsa05012	2.02154721
9	Arginine biosynthesis_Homo sapiens_hsa00220	1.84858965
10	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.84580032
11	One carbon pool by folate_Homo sapiens_hsa00670	1.76707591
12	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.71514614
13	Basal transcription factors_Homo sapiens_hsa03022	1.70309845
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.68005335
15	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.67281807
16	Sulfur relay system_Homo sapiens_hsa04122	1.66601595
17	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.63775075
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.62570921
19	Alzheimers disease_Homo sapiens_hsa05010	1.62442438
20	Huntingtons disease_Homo sapiens_hsa05016	1.62158831
21	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.54305323
22	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.47359658
23	Protein export_Homo sapiens_hsa03060	1.47017813
24	Glutathione metabolism_Homo sapiens_hsa00480	1.46253723
25	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.41073029
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.39040437
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38766357
28	Basal cell carcinoma_Homo sapiens_hsa05217	1.38473049
29	Calcium signaling pathway_Homo sapiens_hsa04020	1.38269057
30	Proteasome_Homo sapiens_hsa03050	1.36600171
31	RNA degradation_Homo sapiens_hsa03018	1.36574371
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.34846039
33	RNA polymerase_Homo sapiens_hsa03020	1.33836479
34	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.33594263
35	Pyruvate metabolism_Homo sapiens_hsa00620	1.32266430
36	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.31471797
37	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.27495769
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.24562972
39	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.24370962
40	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.20444827
41	Olfactory transduction_Homo sapiens_hsa04740	1.19995176
42	Arginine and proline metabolism_Homo sapiens_hsa00330	1.18103205
43	RNA transport_Homo sapiens_hsa03013	1.04758979
44	Wnt signaling pathway_Homo sapiens_hsa04310	1.01873910
45	beta-Alanine metabolism_Homo sapiens_hsa00410	0.95449221
46	Circadian rhythm_Homo sapiens_hsa04710	0.95171394
47	Propanoate metabolism_Homo sapiens_hsa00640	0.93955508
48	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.93932868
49	Carbon metabolism_Homo sapiens_hsa01200	0.93199914
50	Circadian entrainment_Homo sapiens_hsa04713	0.92184059
51	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.90776829
52	Glucagon signaling pathway_Homo sapiens_hsa04922	0.90568752
53	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.90534221
54	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.88916640
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.85450911
56	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.83200542
57	Pancreatic secretion_Homo sapiens_hsa04972	0.83097228
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.81187514
59	Selenocompound metabolism_Homo sapiens_hsa00450	0.75173242
60	Purine metabolism_Homo sapiens_hsa00230	0.75150365
61	Fatty acid degradation_Homo sapiens_hsa00071	0.75077509
62	Butanoate metabolism_Homo sapiens_hsa00650	0.74499651
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73390416
64	Gastric acid secretion_Homo sapiens_hsa04971	0.72863659
65	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.71775996
66	ABC transporters_Homo sapiens_hsa02010	0.71160065
67	Insulin secretion_Homo sapiens_hsa04911	0.70683129
68	Peroxisome_Homo sapiens_hsa04146	0.69501171
69	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.69437930
70	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.67893216
71	Tryptophan metabolism_Homo sapiens_hsa00380	0.67755732
72	Spliceosome_Homo sapiens_hsa03040	0.67102519
73	Histidine metabolism_Homo sapiens_hsa00340	0.66402928
74	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.64928061
75	Renin secretion_Homo sapiens_hsa04924	0.64464116
76	Oocyte meiosis_Homo sapiens_hsa04114	0.63830318
77	Morphine addiction_Homo sapiens_hsa05032	0.61418403
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.56735672
79	Pyrimidine metabolism_Homo sapiens_hsa00240	0.54150447
80	Axon guidance_Homo sapiens_hsa04360	0.53236079
81	Taste transduction_Homo sapiens_hsa04742	0.53229726
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53014773
83	Melanogenesis_Homo sapiens_hsa04916	0.51493968
84	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.50392977
85	Caffeine metabolism_Homo sapiens_hsa00232	0.48109059
86	Salivary secretion_Homo sapiens_hsa04970	0.46666483
87	Cholinergic synapse_Homo sapiens_hsa04725	0.45415877
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.44424627
89	Steroid biosynthesis_Homo sapiens_hsa00100	0.44305136
90	Metabolic pathways_Homo sapiens_hsa01100	0.38947846
91	Estrogen signaling pathway_Homo sapiens_hsa04915	0.35928431
92	Alcoholism_Homo sapiens_hsa05034	0.35438865
93	GABAergic synapse_Homo sapiens_hsa04727	0.34772113
94	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.34511839
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33833100
96	Amphetamine addiction_Homo sapiens_hsa05031	0.32030382
97	Homologous recombination_Homo sapiens_hsa03440	0.31482529
98	Retinol metabolism_Homo sapiens_hsa00830	0.30554861
99	Lysine degradation_Homo sapiens_hsa00310	0.30023353
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.29135788

RPL19P14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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