RPL19P18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of Wnt signaling pathway involved in heart development (GO:0003307)9.01586985
2protein refolding (GO:0042026)8.55803829
3mRNA transcription (GO:0009299)7.99285759
4negative regulation of cell fate specification (GO:0009996)7.93053858
5regulation of inclusion body assembly (GO:0090083)7.51386170
6renal system development (GO:0072001)7.16509446
7embryonic heart tube development (GO:0035050)6.98234358
8endothelial tube morphogenesis (GO:0061154)6.84239179
9morphogenesis of an endothelium (GO:0003159)6.84239179
10negative regulation of cell fate commitment (GO:0010454)6.71363857
11endoderm formation (GO:0001706)6.68572443
12synaptic transmission, cholinergic (GO:0007271)6.66263638
13embryonic foregut morphogenesis (GO:0048617)6.20071214
14regulation of transcription involved in cell fate commitment (GO:0060850)6.13247867
15positive regulation of skeletal muscle tissue development (GO:0048643)6.03577104
16cell migration involved in gastrulation (GO:0042074)5.87148339
17regulation of mesoderm development (GO:2000380)5.73955431
18organ formation (GO:0048645)5.45079606
19endothelium development (GO:0003158)5.21729415
20chaperone mediated protein folding requiring cofactor (GO:0051085)5.09132078
21establishment of protein localization to mitochondrial membrane (GO:0090151)4.93703799
22axon ensheathment in central nervous system (GO:0032291)4.57907031
23central nervous system myelination (GO:0022010)4.57907031
24axonemal dynein complex assembly (GO:0070286)4.57236591
25negative regulation of erythrocyte differentiation (GO:0045647)4.44030528
26digestive tract morphogenesis (GO:0048546)4.41322794
27opioid receptor signaling pathway (GO:0038003)4.29920172
28endothelial cell differentiation (GO:0045446)4.28079795
29negative regulation of protein autophosphorylation (GO:0031953)4.15736223
30cilium movement (GO:0003341)4.13427240
31regulation of cell fate specification (GO:0042659)4.07788999
32notochord development (GO:0030903)4.03377662
33Notch signaling involved in heart development (GO:0061314)4.01725417
34signal transduction involved in regulation of gene expression (GO:0023019)3.97624688
35type B pancreatic cell development (GO:0003323)3.97322638
36presynaptic membrane assembly (GO:0097105)3.94156514
37negative regulation of embryonic development (GO:0045992)3.84497599
38microglial cell activation (GO:0001774)3.79938178
39neuron fate determination (GO:0048664)3.69809277
40pattern specification involved in kidney development (GO:0061004)3.62209733
41radial glial cell differentiation (GO:0060019)3.56942983
42cellular response to interferon-beta (GO:0035458)3.52789192
43positive regulation of erythrocyte differentiation (GO:0045648)3.47717696
44glucosamine-containing compound catabolic process (GO:1901072)3.42846744
45negative regulation of glial cell differentiation (GO:0045686)3.36867687
46regulation of podosome assembly (GO:0071801)3.33680482
47outflow tract morphogenesis (GO:0003151)3.30958669
48SMAD protein signal transduction (GO:0060395)3.25645858
49ubiquinone biosynthetic process (GO:0006744)3.25245983
50ubiquinone metabolic process (GO:0006743)3.24784113
51negative regulation by host of viral transcription (GO:0043922)3.23242932
52cellular response to heat (GO:0034605)3.20013602
53L-fucose catabolic process (GO:0042355)3.19510980
54fucose catabolic process (GO:0019317)3.19510980
55L-fucose metabolic process (GO:0042354)3.19510980
56presynaptic membrane organization (GO:0097090)3.18355063
57ventricular trabecula myocardium morphogenesis (GO:0003222)3.14311908
58Notch receptor processing (GO:0007220)3.14015919
59positive regulation by host of viral transcription (GO:0043923)3.13709432
60regulation of endothelial cell chemotaxis (GO:2001026)3.13223251
61heart valve formation (GO:0003188)3.12562580
62regulation of cell fate commitment (GO:0010453)3.12409538
63response to gravity (GO:0009629)3.12153193
64cellular response to thyroid hormone stimulus (GO:0097067)3.10394407
65limb development (GO:0060173)3.08489506
66appendage development (GO:0048736)3.08489506
67regulation of erythrocyte differentiation (GO:0045646)3.08001421
68epithelial cilium movement (GO:0003351)3.02930332
69cilium or flagellum-dependent cell motility (GO:0001539)3.01516368
70cranial nerve development (GO:0021545)3.01286384
71neuronal stem cell maintenance (GO:0097150)2.95427153
72regulation of gastrulation (GO:0010470)2.91826826
73hindlimb morphogenesis (GO:0035137)2.86029009
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.85083088
75negative regulation of oligodendrocyte differentiation (GO:0048715)2.76913650
76pancreas development (GO:0031016)2.76737253
77S-adenosylmethionine metabolic process (GO:0046500)2.74957289
78negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.74385999
79telencephalon development (GO:0021537)2.73128168
80asymmetric protein localization (GO:0008105)2.72886167
81positive regulation of glial cell differentiation (GO:0045687)2.71919705
82positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.69473598
83lymphangiogenesis (GO:0001946)2.68174423
84neuron cell-cell adhesion (GO:0007158)2.67871216
85neurotransmitter catabolic process (GO:0042135)2.67312036
86somite development (GO:0061053)2.65390344
87positive regulation of Notch signaling pathway (GO:0045747)2.64602826
88forelimb morphogenesis (GO:0035136)2.63779543
89heart trabecula morphogenesis (GO:0061384)2.61974273
90cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.61763600
91quinone biosynthetic process (GO:1901663)2.61163409
92regulation of monocyte differentiation (GO:0045655)2.60707095
93cell proliferation involved in kidney development (GO:0072111)2.60276583
94smoothened signaling pathway (GO:0007224)2.60251632
95tongue development (GO:0043586)2.60028435
96oligodendrocyte differentiation (GO:0048709)2.59330504
97inner ear receptor stereocilium organization (GO:0060122)2.58344761
98sequestering of actin monomers (GO:0042989)2.57454470
99negative regulation of inclusion body assembly (GO:0090084)12.7567699
100mRNA transcription from RNA polymerase II promoter (GO:0042789)10.0485745

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.75734825
2EED_16625203_ChIP-ChIP_MESCs_Mouse2.85357828
3CBX2_27304074_Chip-Seq_ESCs_Mouse2.82112990
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.61890791
5SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55029316
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.51140987
7VDR_22108803_ChIP-Seq_LS180_Human2.44376123
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40922847
9RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.39194865
10PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.30894466
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.30272016
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29100943
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.27514716
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27164969
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.26058609
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11604198
17EWS_26573619_Chip-Seq_HEK293_Human2.08134953
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.07384694
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.07384694
20IRF1_19129219_ChIP-ChIP_H3396_Human2.06359764
21RNF2_27304074_Chip-Seq_NSC_Mouse2.00772650
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.96429003
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.96429003
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.96429003
25TP53_20018659_ChIP-ChIP_R1E_Mouse1.96039152
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.95977431
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95974531
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95938612
29FUS_26573619_Chip-Seq_HEK293_Human1.95392266
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93749498
31AR_21572438_ChIP-Seq_LNCaP_Human1.88965720
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84306377
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83705124
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82340769
35GBX2_23144817_ChIP-Seq_PC3_Human1.75445529
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.71704603
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.70557825
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63485746
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60276846
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.57127949
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52844261
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51279118
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48946259
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48687517
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.48278234
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.48252402
47ZNF274_21170338_ChIP-Seq_K562_Hela1.48235502
48P300_19829295_ChIP-Seq_ESCs_Human1.45558751
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44142547
50RING1B_27294783_Chip-Seq_NPCs_Mouse1.39777628
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38575415
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35843547
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35381079
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35381079
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34990698
56HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33356983
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31003568
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.30139377
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28949401
60MYC_18940864_ChIP-ChIP_HL60_Human1.26470963
61RXR_22108803_ChIP-Seq_LS180_Human1.26344646
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24181670
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21956614
64TAF15_26573619_Chip-Seq_HEK293_Human1.19748831
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17065367
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.16450366
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16450366
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16078704
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16029012
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.15582614
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14664337
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14483442
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13075427
74SMAD4_21799915_ChIP-Seq_A2780_Human1.12424813
75RUNX2_22187159_ChIP-Seq_PCA_Human1.10482332
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.08645356
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07748380
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06207820
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05947324
80CBP_20019798_ChIP-Seq_JUKART_Human1.05947324
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05943802
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05939905
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05633569
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05489110
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04983170
86ER_23166858_ChIP-Seq_MCF-7_Human1.03599180
87SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01387232
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.00741344
89SMAD4_21741376_ChIP-Seq_EPCs_Human0.98095431
90BCAT_22108803_ChIP-Seq_LS180_Human0.97848579
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97655095
92AR_25329375_ChIP-Seq_VCAP_Human0.94891319
93RUNX_20019798_ChIP-Seq_JUKART_Human0.94762867
94STAT3_18555785_Chip-Seq_ESCs_Mouse0.94548410
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94372032
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94043774
97PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93759119
98EST1_17652178_ChIP-ChIP_JURKAT_Human0.93428943
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92733951
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92012301

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004233_abnormal_muscle_weight7.24124212
2MP0002928_abnormal_bile_duct6.31896416
3MP0005084_abnormal_gallbladder_morpholo6.30225285
4MP0003136_yellow_coat_color5.19972377
5MP0008007_abnormal_cellular_replicative3.99395675
6MP0003943_abnormal_hepatobiliary_system3.03846154
7MP0002653_abnormal_ependyma_morphology3.02366621
8MP0008058_abnormal_DNA_repair2.80280239
9MP0000343_altered_response_to2.35854723
10MP0000465_gastrointestinal_hemorrhage2.21952604
11MP0002249_abnormal_larynx_morphology2.03100007
12MP0002269_muscular_atrophy1.67413694
13MP0004142_abnormal_muscle_tone1.63104186
14MP0010368_abnormal_lymphatic_system1.62272622
15MP0009250_abnormal_appendicular_skeleto1.58730478
16MP0001968_abnormal_touch/_nociception1.55762147
17MP0003119_abnormal_digestive_system1.50195974
18MP0004885_abnormal_endolymph1.46891423
19MP0002736_abnormal_nociception_after1.43401423
20MP0001986_abnormal_taste_sensitivity1.39404585
21MP0001270_distended_abdomen1.39294787
22MP0001958_emphysema1.37624542
23MP0001944_abnormal_pancreas_morphology1.36028464
24MP0001485_abnormal_pinna_reflex1.26571471
25MP0003283_abnormal_digestive_organ1.25449453
26MP0002233_abnormal_nose_morphology1.22149725
27MP0004742_abnormal_vestibular_system1.22017966
28MP0001286_abnormal_eye_development1.21110730
29MP0004272_abnormal_basement_membrane1.20996711
30MP0002272_abnormal_nervous_system1.19855446
31MP0009672_abnormal_birth_weight1.15958601
32MP0002277_abnormal_respiratory_mucosa1.15804390
33MP0002697_abnormal_eye_size1.15106092
34MP0009379_abnormal_foot_pigmentation1.11423365
35MP0001299_abnormal_eye_distance/1.10972188
36MP0001879_abnormal_lymphatic_vessel1.10644089
37MP0004808_abnormal_hematopoietic_stem1.08938683
38MP0001905_abnormal_dopamine_level1.08455651
39MP0005448_abnormal_energy_balance1.07553782
40MP0005377_hearing/vestibular/ear_phenot1.07144131
41MP0003878_abnormal_ear_physiology1.07144131
42MP0010094_abnormal_chromosome_stability1.04470192
43MP0009745_abnormal_behavioral_response1.03868000
44MP0000026_abnormal_inner_ear1.01768290
45MP0002282_abnormal_trachea_morphology1.01682587
46MP0008875_abnormal_xenobiotic_pharmacok1.01478204
47MP0005551_abnormal_eye_electrophysiolog0.99142694
48MP0001293_anophthalmia0.91030631
49MP0002064_seizures0.90945239
50MP0005503_abnormal_tendon_morphology0.88857109
51MP0000762_abnormal_tongue_morphology0.87658526
52MP0001486_abnormal_startle_reflex0.87253895
53MP0003880_abnormal_central_pattern0.86755228
54MP0000778_abnormal_nervous_system0.85899374
55MP0002735_abnormal_chemical_nociception0.85537470
56MP0003755_abnormal_palate_morphology0.83535182
57MP0000631_abnormal_neuroendocrine_gland0.83173858
58MP0002067_abnormal_sensory_capabilities0.80701300
59MP0000685_abnormal_immune_system0.78953953
60MP0005595_abnormal_vascular_smooth0.78923281
61MP0001501_abnormal_sleep_pattern0.77892386
62MP0009764_decreased_sensitivity_to0.76356121
63MP0001502_abnormal_circadian_rhythm0.75402407
64MP0005391_vision/eye_phenotype0.73544495
65MP0008872_abnormal_physiological_respon0.73509281
66MP0001963_abnormal_hearing_physiology0.72138630
67MP0000372_irregular_coat_pigmentation0.71701453
68MP0009703_decreased_birth_body0.70493244
69MP0001340_abnormal_eyelid_morphology0.69172445
70MP0002752_abnormal_somatic_nervous0.68539410
71MP0000249_abnormal_blood_vessel0.66668562
72MP0002138_abnormal_hepatobiliary_system0.64225707
73MP0000955_abnormal_spinal_cord0.62824229
74MP0005253_abnormal_eye_physiology0.62476486
75MP0005075_abnormal_melanosome_morpholog0.61331570
76MP0001529_abnormal_vocalization0.60210555
77MP0001851_eye_inflammation0.59669994
78MP0003186_abnormal_redox_activity0.59484708
79MP0002092_abnormal_eye_morphology0.58178269
80MP0003724_increased_susceptibility_to0.57260510
81MP0005187_abnormal_penis_morphology0.56501308
82MP0002572_abnormal_emotion/affect_behav0.56122940
83MP0004133_heterotaxia0.55790771
84MP0000049_abnormal_middle_ear0.55496534
85MP0003632_abnormal_nervous_system0.54774234
86MP0002638_abnormal_pupillary_reflex0.54529811
87MP0000534_abnormal_ureter_morphology0.53242112
88MP0001984_abnormal_olfaction0.51872498
89MP0001324_abnormal_eye_pigmentation0.51573998
90MP0005195_abnormal_posterior_eye0.51018970
91MP0002693_abnormal_pancreas_physiology0.50219124
92MP0005367_renal/urinary_system_phenotyp0.48804281
93MP0000516_abnormal_urinary_system0.48804281
94MP0003635_abnormal_synaptic_transmissio0.48804196
95MP0004019_abnormal_vitamin_homeostasis0.48398904
96MP0005646_abnormal_pituitary_gland0.48335767
97MP0003879_abnormal_hair_cell0.48088766
98MP0005620_abnormal_muscle_contractility0.47063971
99MP0002148_abnormal_hypersensitivity_rea0.46676367
100MP0002734_abnormal_mechanical_nocicepti0.46435744

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber atrophy (HP:0100295)9.09829904
2Fatigable weakness (HP:0003473)6.73933131
3Abnormality of the neuromuscular junction (HP:0003398)6.73933131
4Nonprogressive disorder (HP:0003680)6.28298982
5Poor suck (HP:0002033)6.20334443
6Weak cry (HP:0001612)5.73806947
7Hydroureter (HP:0000072)5.71045977
8Decreased muscle mass (HP:0003199)5.26543637
9Easy fatigability (HP:0003388)4.78277499
10Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.56810244
11Abnormal respiratory motile cilium physiology (HP:0012261)4.46234380
12Fibular hypoplasia (HP:0003038)4.36077158
13Abnormality of the columella (HP:0009929)4.32570860
14Abnormal ciliary motility (HP:0012262)4.07930946
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.06365036
16Aplasia/Hypoplasia involving the sinuses (HP:0009120)4.06150797
17Bulbar palsy (HP:0001283)4.01554484
18Generalized muscle weakness (HP:0003324)3.99310264
19Abnormality of the frontal sinuses (HP:0002687)3.90673699
20Aplasia/Hypoplasia of the fibula (HP:0006492)3.73414675
21Median cleft lip (HP:0000161)3.70515576
22True hermaphroditism (HP:0010459)3.66918789
23Rhinitis (HP:0012384)3.55591861
24Esophageal atresia (HP:0002032)3.53235292
25Anophthalmia (HP:0000528)3.34826910
26High anterior hairline (HP:0009890)3.31781519
27Oligodactyly (hands) (HP:0001180)3.24616260
28Abnormality of the incisor (HP:0000676)3.03566566
29Gonadotropin excess (HP:0000837)2.92956038
30Abnormal respiratory epithelium morphology (HP:0012253)2.79623511
31Abnormal respiratory motile cilium morphology (HP:0005938)2.79623511
32Gastrointestinal atresia (HP:0002589)2.69737780
33Gowers sign (HP:0003391)2.54223161
34Aplasia/Hypoplasia of the tibia (HP:0005772)2.48699202
35Short tibia (HP:0005736)2.45689148
36Abnormal number of incisors (HP:0011064)2.42184670
37Chronic bronchitis (HP:0004469)2.41292865
38Missing ribs (HP:0000921)2.37811756
39Severe muscular hypotonia (HP:0006829)2.33894246
40Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.24594566
41Vertebral hypoplasia (HP:0008417)2.24594566
42Rib fusion (HP:0000902)2.22898220
43Abnormality of DNA repair (HP:0003254)2.21373129
44Depressed nasal tip (HP:0000437)2.21268633
4511 pairs of ribs (HP:0000878)2.20999706
46Sclerocornea (HP:0000647)2.20620979
47Pancreatic cysts (HP:0001737)2.20577632
48Calf muscle hypertrophy (HP:0008981)2.15508977
49Pancreatic fibrosis (HP:0100732)2.15452437
50Chronic sinusitis (HP:0011109)2.12837697
51Septo-optic dysplasia (HP:0100842)2.06878177
52Abnormality of the fibula (HP:0002991)2.06333507
53Menstrual irregularities (HP:0000858)2.04077026
54Type 2 muscle fiber atrophy (HP:0003554)10.3175996
55Absent/shortened dynein arms (HP:0200106)1.99311974
56Dynein arm defect of respiratory motile cilia (HP:0012255)1.99311974
57Split foot (HP:0001839)1.97813076
58Bronchiectasis (HP:0002110)1.94495087
59Medial flaring of the eyebrow (HP:0010747)1.92810284
60Cystic liver disease (HP:0006706)1.91803351
61Postaxial hand polydactyly (HP:0001162)1.90946085
62Type II lissencephaly (HP:0007260)1.90545739
63Muscle hypertrophy of the lower extremities (HP:0008968)1.88316038
64Oligodactyly (HP:0012165)1.87595883
65Abnormal number of erythroid precursors (HP:0012131)1.87511677
66Abnormality of the diencephalon (HP:0010662)1.83099945
67Decreased central vision (HP:0007663)1.82199189
68Ulnar claw (HP:0001178)1.81427017
69Abnormal sex determination (HP:0012244)1.81147168
70Sex reversal (HP:0012245)1.81147168
71Infertility (HP:0000789)1.78539776
72Abnormality of the 4th metacarpal (HP:0010012)1.77688571
73Benign neoplasm of the central nervous system (HP:0100835)1.77054664
74Molar tooth sign on MRI (HP:0002419)1.75689023
75Abnormality of midbrain morphology (HP:0002418)1.75689023
76Abnormality of the nasal mucosa (HP:0000433)1.75631160
77Abnormality of the pons (HP:0007361)1.74746438
78Abnormality of cells of the erythroid lineage (HP:0012130)1.73087016
79Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72449709
80Tibial bowing (HP:0002982)1.70328027
81Postaxial foot polydactyly (HP:0001830)1.67010727
82Scotoma (HP:0000575)1.66167253
83Hemivertebrae (HP:0002937)1.65968459
84Gait imbalance (HP:0002141)1.65143079
85Cerebellar dysplasia (HP:0007033)1.63021065
86Bilateral microphthalmos (HP:0007633)1.62196664
87Respiratory insufficiency due to muscle weakness (HP:0002747)1.60497216
88Poor coordination (HP:0002370)1.59660866
89Bone cyst (HP:0012062)1.58280875
90Fibular aplasia (HP:0002990)1.57256249
91Congenital, generalized hypertrichosis (HP:0004540)1.56576171
92Neonatal short-limb short stature (HP:0008921)1.53043633
93Nasal polyposis (HP:0100582)1.51610201
94Congenital primary aphakia (HP:0007707)1.51259315
95Male pseudohermaphroditism (HP:0000037)1.48248933
96Occipital encephalocele (HP:0002085)1.47414956
97Vertebral fusion (HP:0002948)1.46485695
98Maternal diabetes (HP:0009800)1.45555966
99Congenital stationary night blindness (HP:0007642)1.44559870
100Aplasia/Hypoplasia of the tongue (HP:0010295)1.44306767

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.39745230
2PNCK3.14278961
3VRK12.50640206
4TAOK32.12292740
5WEE12.09274820
6PDK22.04799606
7TSSK612.1100905
8TIE11.77657116
9FRK1.55711962
10CDK31.47974119
11IRAK11.40402878
12MAPKAPK31.29413857
13MAPKAPK51.20890625
14MKNK21.04491826
15TRIM280.94702814
16ADRBK20.94592268
17PLK30.93689654
18MAP3K40.90012445
19NME10.85917820
20TAF10.85592265
21IRAK20.84119663
22CASK0.81830143
23MAP2K70.79091809
24GRK10.74837099
25IRAK40.72949108
26MKNK10.70992323
27NEK60.67359527
28MAPK130.66274386
29TYRO30.65298896
30MAP2K20.63738356
31DMPK0.62334610
32EPHA30.61307835
33PAK20.59811487
34MAP3K100.57743538
35BMPR1B0.55835936
36BMPR20.54296793
37PRKD30.51191986
38EPHB10.47937018
39PRKCH0.47682595
40PRKCG0.46894883
41PAK40.44707625
42RPS6KA50.43977309
43MAPK70.43432382
44PINK10.42898683
45GSK3A0.40988747
46IKBKE0.40623296
47MAPK120.39090021
48PRKD10.38340318
49CDK120.38104785
50PRKCE0.37755813
51DYRK1A0.36861781
52NTRK20.36409807
53BRSK20.36130522
54DYRK30.35479767
55ADRBK10.35332531
56PASK0.34079925
57NLK0.33365302
58BRD40.32578768
59PIK3CA0.31589453
60RPS6KB20.29980009
61TGFBR10.29696001
62RPS6KA40.29134393
63MARK30.28977913
64PKN10.28930714
65CSNK1G10.27904339
66PRKCI0.27094632
67MAP3K70.26655222
68DYRK20.24199119
69FGFR30.24005191
70PRKG10.21708728
71TLK10.20890827
72MARK10.20404219
73ZAK0.19017776
74SGK20.18377754
75OXSR10.17570550
76RPS6KA10.16278811
77IKBKB0.15729357
78INSRR0.15304760
79PLK20.15292673
80PRKD20.15232145
81EIF2AK20.13216910
82LMTK20.12426916
83MAPK100.12099563
84MAP3K120.11203550
85MAPKAPK20.10493825
86DDR20.10492312
87CSNK2A20.08715738
88PHKG20.08601003
89PHKG10.08601003
90CSNK1G20.07384126
91TXK0.07000035
92PRKCZ0.06789704
93PTK60.06722736
94PIM20.06569782
95PRKACA0.05650664
96MAPK40.05576771
97CAMK2A0.05567184
98MAP4K10.04860588
99ERBB30.04844249
100MAP4K20.04388285

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.46384828
2Legionellosis_Homo sapiens_hsa051343.23550903
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.00735900
4Antigen processing and presentation_Homo sapiens_hsa046122.96073087
5Prion diseases_Homo sapiens_hsa050202.96053243
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.61381521
7Ribosome_Homo sapiens_hsa030102.49195869
8Estrogen signaling pathway_Homo sapiens_hsa049152.36002714
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.22407609
10Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.09922246
11Cocaine addiction_Homo sapiens_hsa050302.05247827
12Asthma_Homo sapiens_hsa053101.98240387
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.94160472
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.92744141
15Phototransduction_Homo sapiens_hsa047441.75914631
16Protein export_Homo sapiens_hsa030601.69174637
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68593862
18Butanoate metabolism_Homo sapiens_hsa006501.59473271
19Olfactory transduction_Homo sapiens_hsa047401.57146600
20Amphetamine addiction_Homo sapiens_hsa050311.50455735
21Allograft rejection_Homo sapiens_hsa053301.47355003
22Parkinsons disease_Homo sapiens_hsa050121.44168935
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.43150218
24Toxoplasmosis_Homo sapiens_hsa051451.38334826
25Type I diabetes mellitus_Homo sapiens_hsa049401.32845072
26GABAergic synapse_Homo sapiens_hsa047271.30168772
27Notch signaling pathway_Homo sapiens_hsa043301.28816203
28Leishmaniasis_Homo sapiens_hsa051401.28637891
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28576424
30MAPK signaling pathway_Homo sapiens_hsa040101.24637635
31Hedgehog signaling pathway_Homo sapiens_hsa043401.17700872
32Fanconi anemia pathway_Homo sapiens_hsa034601.16775257
33Measles_Homo sapiens_hsa051621.16141238
34Arachidonic acid metabolism_Homo sapiens_hsa005901.12098196
35Nicotine addiction_Homo sapiens_hsa050331.09273882
36Arginine biosynthesis_Homo sapiens_hsa002201.06265581
37Cardiac muscle contraction_Homo sapiens_hsa042601.05545118
38Influenza A_Homo sapiens_hsa051641.05476000
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05110869
40Homologous recombination_Homo sapiens_hsa034401.01405289
41Graft-versus-host disease_Homo sapiens_hsa053321.00959816
42Oxidative phosphorylation_Homo sapiens_hsa001900.99390247
43Rheumatoid arthritis_Homo sapiens_hsa053230.99118819
44African trypanosomiasis_Homo sapiens_hsa051430.98066429
45Autoimmune thyroid disease_Homo sapiens_hsa053200.96902814
46Steroid biosynthesis_Homo sapiens_hsa001000.96288098
47Huntingtons disease_Homo sapiens_hsa050160.96235094
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88668860
49Wnt signaling pathway_Homo sapiens_hsa043100.87721052
50Linoleic acid metabolism_Homo sapiens_hsa005910.87669881
51Taste transduction_Homo sapiens_hsa047420.87600323
52Basal cell carcinoma_Homo sapiens_hsa052170.86932001
53Selenocompound metabolism_Homo sapiens_hsa004500.86149100
54Insulin secretion_Homo sapiens_hsa049110.85946904
55Spliceosome_Homo sapiens_hsa030400.82203596
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79156788
57cAMP signaling pathway_Homo sapiens_hsa040240.77133368
58Folate biosynthesis_Homo sapiens_hsa007900.76344164
59Thyroid hormone synthesis_Homo sapiens_hsa049180.75885140
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73707744
61Morphine addiction_Homo sapiens_hsa050320.73347442
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72609362
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71790277
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71760892
65Epstein-Barr virus infection_Homo sapiens_hsa051690.71026167
66Malaria_Homo sapiens_hsa051440.70123551
67Hematopoietic cell lineage_Homo sapiens_hsa046400.68411090
68TNF signaling pathway_Homo sapiens_hsa046680.66134895
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64835599
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60206403
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58056143
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56015984
73Glutamatergic synapse_Homo sapiens_hsa047240.55521621
74RNA degradation_Homo sapiens_hsa030180.54016815
75Pertussis_Homo sapiens_hsa051330.53067412
76Circadian entrainment_Homo sapiens_hsa047130.51057666
77Hippo signaling pathway_Homo sapiens_hsa043900.49746739
78Caffeine metabolism_Homo sapiens_hsa002320.49028120
79TGF-beta signaling pathway_Homo sapiens_hsa043500.45520200
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45328590
81Chemical carcinogenesis_Homo sapiens_hsa052040.44787452
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42655068
83Peroxisome_Homo sapiens_hsa041460.41885600
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41689797
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40046241
86Alzheimers disease_Homo sapiens_hsa050100.39374972
87Primary immunodeficiency_Homo sapiens_hsa053400.38649011
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34981257
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34072502
90RNA polymerase_Homo sapiens_hsa030200.33892299
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33402416
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33256565
93Retinol metabolism_Homo sapiens_hsa008300.32912368
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.32156792
95Salmonella infection_Homo sapiens_hsa051320.31781372
96One carbon pool by folate_Homo sapiens_hsa006700.29700914
97T cell receptor signaling pathway_Homo sapiens_hsa046600.29011623
98Ovarian steroidogenesis_Homo sapiens_hsa049130.28966846
99Proteasome_Homo sapiens_hsa030500.28099794
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27794717

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