ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.74412077
2	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	5.61544589
3	base-excision repair, AP site formation (GO:0006285)	5.23916736
4	pyrimidine nucleotide catabolic process (GO:0006244)	4.79545346
5	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.69175546
6	ribosomal small subunit biogenesis (GO:0042274)	4.57231942
7	piRNA metabolic process (GO:0034587)	4.54648357
8	DNA deamination (GO:0045006)	4.54592457
9	viral transcription (GO:0019083)	4.46498143
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.37597695
11	ATP synthesis coupled proton transport (GO:0015986)	4.37597695
12	translational termination (GO:0006415)	4.31714947
13	behavioral response to nicotine (GO:0035095)	4.29661735
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.25486455
15	protein complex biogenesis (GO:0070271)	4.22470478
16	signal peptide processing (GO:0006465)	4.12622804
17	respiratory chain complex IV assembly (GO:0008535)	4.11594601
18	protein-cofactor linkage (GO:0018065)	4.07839848
19	rRNA modification (GO:0000154)	3.99992298
20	maturation of SSU-rRNA (GO:0030490)	3.96439394
21	cytochrome complex assembly (GO:0017004)	3.95402373
22	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.85039422
23	translational elongation (GO:0006414)	3.83500328
24	GTP biosynthetic process (GO:0006183)	3.83445069
25	cotranslational protein targeting to membrane (GO:0006613)	3.79104827
26	pseudouridine synthesis (GO:0001522)	3.79083280
27	protein targeting to ER (GO:0045047)	3.77936414
28	mitochondrial respiratory chain complex assembly (GO:0033108)	3.77565939
29	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.76751979
30	mannosylation (GO:0097502)	3.76479991
31	DNA methylation involved in gamete generation (GO:0043046)	3.76106777
32	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.64149793
33	water-soluble vitamin biosynthetic process (GO:0042364)	3.61960609
34	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.58085520
35	protein localization to endoplasmic reticulum (GO:0070972)	3.56213281
36	maturation of 5.8S rRNA (GO:0000460)	3.55326072
37	chaperone-mediated protein transport (GO:0072321)	3.51349086
38	termination of RNA polymerase III transcription (GO:0006386)	3.51191053
39	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.51191053
40	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.50360708
41	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.50360708
42	NADH dehydrogenase complex assembly (GO:0010257)	3.50360708
43	ribosomal large subunit biogenesis (GO:0042273)	3.41364697
44	regulation of mitochondrial translation (GO:0070129)	3.38840204
45	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.38433142
46	prenylation (GO:0097354)	3.34843411
47	protein prenylation (GO:0018342)	3.34843411
48	rRNA catabolic process (GO:0016075)	3.33404880
49	UTP metabolic process (GO:0046051)	3.33213534
50	UTP biosynthetic process (GO:0006228)	3.29227080
51	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.29215837
52	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.28340565
53	viral life cycle (GO:0019058)	3.28073296
54	respiratory electron transport chain (GO:0022904)	3.24436457
55	translation (GO:0006412)	3.24235157
56	electron transport chain (GO:0022900)	3.23018156
57	negative regulation of JAK-STAT cascade (GO:0046426)	3.21638297
58	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.18875125
59	regulation of immunoglobulin secretion (GO:0051023)	3.16752448
60	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.16694425
61	rRNA methylation (GO:0031167)	3.14689303
62	cellular component biogenesis (GO:0044085)	3.13573477
63	valine metabolic process (GO:0006573)	3.13568243
64	translational initiation (GO:0006413)	3.12184485
65	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.11802519
66	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.11802519
67	cellular protein complex disassembly (GO:0043624)	3.11565480
68	DNA catabolic process, exonucleolytic (GO:0000738)	3.07834937
69	negative regulation of telomere maintenance (GO:0032205)	3.02499321
70	rRNA metabolic process (GO:0016072)	3.02122913
71	rRNA processing (GO:0006364)	2.98023892
72	CTP biosynthetic process (GO:0006241)	2.97453356
73	CTP metabolic process (GO:0046036)	2.97453356
74	preassembly of GPI anchor in ER membrane (GO:0016254)	2.97146420
75	negative regulation of membrane potential (GO:0045837)	2.96925392
76	vitamin transmembrane transport (GO:0035461)	2.93439791
77	ribonucleoprotein complex biogenesis (GO:0022613)	2.91816626
78	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.91577032
79	positive regulation of catecholamine secretion (GO:0033605)	2.91229677
80	DNA double-strand break processing (GO:0000729)	2.91103750
81	deoxyribonucleotide catabolic process (GO:0009264)	2.89224011
82	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.88619580
83	branched-chain amino acid catabolic process (GO:0009083)	2.87793542
84	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.87337452
85	tRNA processing (GO:0008033)	2.85860647
86	fucose catabolic process (GO:0019317)	2.83170534
87	L-fucose metabolic process (GO:0042354)	2.83170534
88	L-fucose catabolic process (GO:0042355)	2.83170534
89	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.82108598
90	ubiquinone biosynthetic process (GO:0006744)	2.79452110
91	substrate-independent telencephalic tangential migration (GO:0021826)	2.78453761
92	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.78453761
93	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.75740948
94	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.71342815
95	deoxyribose phosphate catabolic process (GO:0046386)	2.71293014
96	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.69492405
97	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.66710267
98	guanosine-containing compound biosynthetic process (GO:1901070)	2.66123371
99	proteasome assembly (GO:0043248)	2.65618040
100	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.63073237

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.54422080
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.26709107
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.16248649
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.03276287
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.96223093
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.68792229
7	ZNF274_21170338_ChIP-Seq_K562_Hela	3.63851403
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.36078042
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.07561531
10	VDR_22108803_ChIP-Seq_LS180_Human	2.93633189
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.88449021
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.73808489
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.54934431
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.43673690
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.34222324
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.30856611
17	EZH2_22144423_ChIP-Seq_EOC_Human	2.20389218
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.10233010
19	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.09354144
20	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.03779663
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.98982806
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.95818269
23	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.82570041
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.81492752
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.74731020
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.73499931
27	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.73103410
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.70462184
29	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.68116208
30	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.66405261
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49160425
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.47808516
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.45271646
34	EWS_26573619_Chip-Seq_HEK293_Human	1.43742103
35	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.43728687
36	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.41619735
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.36144301
38	XRN2_22483619_ChIP-Seq_HELA_Human	1.35765993
39	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.34504830
40	IGF1R_20145208_ChIP-Seq_DFB_Human	1.33022965
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29396448
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29396448
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29359868
44	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.29070224
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28527809
46	GABP_19822575_ChIP-Seq_HepG2_Human	1.28466581
47	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.27776832
48	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.27700889
49	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.23241025
50	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.20953090
51	NCOR_22424771_ChIP-Seq_293T_Human	1.18315598
52	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.17316279
53	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.16203580
54	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14253814
55	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.14053760
56	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.14018498
57	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13061091
58	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11754438
59	GATA3_26560356_Chip-Seq_TH2_Human	1.10301617
60	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.09114208
61	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.07340651
62	DCP1A_22483619_ChIP-Seq_HELA_Human	1.06101903
63	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.05648829
64	MYC_19829295_ChIP-Seq_ESCs_Human	1.02250930
65	E2F7_22180533_ChIP-Seq_HELA_Human	1.01478441
66	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.01028763
67	ERA_21632823_ChIP-Seq_H3396_Human	1.00642744
68	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00159636
69	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.99065645
70	AR_20517297_ChIP-Seq_VCAP_Human	0.97503592
71	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.97169743
72	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.96008353
73	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.95112223
74	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.94826631
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94600269
76	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.94361782
77	P300_19829295_ChIP-Seq_ESCs_Human	0.94033889
78	ER_23166858_ChIP-Seq_MCF-7_Human	0.93735562
79	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.93564081
80	CTCF_20526341_ChIP-Seq_ESCs_Human	0.93300477
81	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.93039864
82	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.92310104
83	NANOG_20526341_ChIP-Seq_ESCs_Human	0.92197732
84	SOX2_19829295_ChIP-Seq_ESCs_Human	0.91719626
85	NANOG_19829295_ChIP-Seq_ESCs_Human	0.91719626
86	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.91267827
87	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90853503
88	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.90844308
89	OCT4_20526341_ChIP-Seq_ESCs_Human	0.90392140
90	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.89769472
91	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.89321566
92	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.89054947
93	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.88098961
94	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.88044168
95	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.87534355
96	TAF2_19829295_ChIP-Seq_ESCs_Human	0.87494193
97	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.87415816
98	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.87304408
99	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.85554697
100	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.84970411

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.50165603
2	MP0006292_abnormal_olfactory_placode	3.30953940
3	MP0002138_abnormal_hepatobiliary_system	3.19821514
4	MP0008877_abnormal_DNA_methylation	2.91880648
5	MP0002837_dystrophic_cardiac_calcinosis	2.86789267
6	MP0002102_abnormal_ear_morphology	2.77116710
7	MP0004885_abnormal_endolymph	2.52973515
8	MP0008875_abnormal_xenobiotic_pharmacok	2.46458993
9	MP0003011_delayed_dark_adaptation	2.33343994
10	MP0003646_muscle_fatigue	2.30498578
11	MP0002638_abnormal_pupillary_reflex	2.25688617
12	MP0001968_abnormal_touch/_nociception	2.24326097
13	MP0002160_abnormal_reproductive_system	2.02255471
14	MP0002736_abnormal_nociception_after	1.99550254
15	MP0003693_abnormal_embryo_hatching	1.94021078
16	MP0008058_abnormal_DNA_repair	1.92033351
17	MP0005646_abnormal_pituitary_gland	1.89954197
18	MP0004145_abnormal_muscle_electrophysio	1.85514044
19	MP0008872_abnormal_physiological_respon	1.80546794
20	MP0005389_reproductive_system_phenotype	1.78425242
21	MP0005551_abnormal_eye_electrophysiolog	1.77027920
22	MP0006072_abnormal_retinal_apoptosis	1.74652975
23	MP0005645_abnormal_hypothalamus_physiol	1.70642073
24	MP0003786_premature_aging	1.65788433
25	MP0000516_abnormal_urinary_system	1.64300007
26	MP0005367_renal/urinary_system_phenotyp	1.64300007
27	MP0004142_abnormal_muscle_tone	1.58677618
28	MP0003183_abnormal_peptide_metabolism	1.54979864
29	MP0005671_abnormal_response_to	1.44745446
30	MP0003878_abnormal_ear_physiology	1.43468403
31	MP0005377_hearing/vestibular/ear_phenot	1.43468403
32	MP0003806_abnormal_nucleotide_metabolis	1.42178574
33	MP0001501_abnormal_sleep_pattern	1.42048483
34	MP0002272_abnormal_nervous_system	1.39927448
35	MP0003718_maternal_effect	1.39915642
36	MP0005084_abnormal_gallbladder_morpholo	1.38534022
37	MP0000427_abnormal_hair_cycle	1.36966664
38	MP0003252_abnormal_bile_duct	1.33828406
39	MP0001835_abnormal_antigen_presentation	1.30147754
40	MP0000569_abnormal_digit_pigmentation	1.28294067
41	MP0002095_abnormal_skin_pigmentation	1.26459129
42	MP0003186_abnormal_redox_activity	1.25899594
43	MP0005085_abnormal_gallbladder_physiolo	1.24413397
44	MP0001986_abnormal_taste_sensitivity	1.23447291
45	MP0003121_genomic_imprinting	1.22659243
46	MP0006276_abnormal_autonomic_nervous	1.19828558
47	MP0002163_abnormal_gland_morphology	1.17230921
48	MP0008995_early_reproductive_senescence	1.10806472
49	MP0002210_abnormal_sex_determination	1.10437731
50	MP0002876_abnormal_thyroid_physiology	1.09556152
51	MP0001984_abnormal_olfaction	1.08957186
52	MP0008775_abnormal_heart_ventricle	1.07779979
53	MP0001502_abnormal_circadian_rhythm	1.05781122
54	MP0009745_abnormal_behavioral_response	1.05533475
55	MP0005075_abnormal_melanosome_morpholog	1.05032085
56	MP0004782_abnormal_surfactant_physiolog	1.04657974
57	MP0000685_abnormal_immune_system	1.01648867
58	MP0001905_abnormal_dopamine_level	1.01404357
59	MP0004147_increased_porphyrin_level	0.99924471
60	MP0005379_endocrine/exocrine_gland_phen	0.98512875
61	MP0004043_abnormal_pH_regulation	0.98420204
62	MP0002277_abnormal_respiratory_mucosa	0.96003884
63	MP0003787_abnormal_imprinting	0.95970856
64	MP0001929_abnormal_gametogenesis	0.95645660
65	MP0001486_abnormal_startle_reflex	0.94394451
66	MP0002148_abnormal_hypersensitivity_rea	0.93238584
67	MP0001293_anophthalmia	0.91495691
68	MP0001919_abnormal_reproductive_system	0.91063854
69	MP0000013_abnormal_adipose_tissue	0.90695057
70	MP0002733_abnormal_thermal_nociception	0.90211236
71	MP0005253_abnormal_eye_physiology	0.89956258
72	MP0000230_abnormal_systemic_arterial	0.89408903
73	MP0000653_abnormal_sex_gland	0.89307688
74	MP0002653_abnormal_ependyma_morphology	0.88011868
75	MP0001145_abnormal_male_reproductive	0.87502513
76	MP0001800_abnormal_humoral_immune	0.87131724
77	MP0003122_maternal_imprinting	0.86498660
78	MP0005636_abnormal_mineral_homeostasis	0.85866673
79	MP0008789_abnormal_olfactory_epithelium	0.84464691
80	MP0006035_abnormal_mitochondrial_morpho	0.83729012
81	MP0000631_abnormal_neuroendocrine_gland	0.83650739
82	MP0000647_abnormal_sebaceous_gland	0.82512664
83	MP0010386_abnormal_urinary_bladder	0.80010112
84	MP0000049_abnormal_middle_ear	0.79256466
85	MP0001765_abnormal_ion_homeostasis	0.78413729
86	MP0003698_abnormal_male_reproductive	0.77931667
87	MP0001790_abnormal_immune_system	0.76265823
88	MP0005387_immune_system_phenotype	0.76265823
89	MP0002557_abnormal_social/conspecific_i	0.76213355
90	MP0005365_abnormal_bile_salt	0.75383847
91	MP0006036_abnormal_mitochondrial_physio	0.74936227
92	MP0002572_abnormal_emotion/affect_behav	0.74690893
93	MP0009333_abnormal_splenocyte_physiolog	0.74604461
94	MP0000613_abnormal_salivary_gland	0.74561865
95	MP0001970_abnormal_pain_threshold	0.74510214
96	MP0005448_abnormal_energy_balance	0.74252307
97	MP0004924_abnormal_behavior	0.73404171
98	MP0005386_behavior/neurological_phenoty	0.73404171
99	MP0001963_abnormal_hearing_physiology	0.72394500
100	MP0001188_hyperpigmentation	0.72219967

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	5.40900648
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	5.09626237
3	Acute necrotizing encephalopathy (HP:0006965)	4.78815892
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.12180608
5	Lipid accumulation in hepatocytes (HP:0006561)	4.01565880
6	Abnormal rod and cone electroretinograms (HP:0008323)	4.01127019
7	Acute encephalopathy (HP:0006846)	3.99947215
8	Progressive macrocephaly (HP:0004481)	3.94953322
9	Mitochondrial inheritance (HP:0001427)	3.85087130
10	Increased CSF lactate (HP:0002490)	3.56576418
11	Retinal dysplasia (HP:0007973)	3.51388206
12	Pendular nystagmus (HP:0012043)	3.43359760
13	Increased hepatocellular lipid droplets (HP:0006565)	3.29377956
14	Decreased central vision (HP:0007663)	3.22749166
15	Cerebral edema (HP:0002181)	3.19253744
16	Increased corneal curvature (HP:0100692)	3.15946865
17	Keratoconus (HP:0000563)	3.15946865
18	Stomatitis (HP:0010280)	2.94112348
19	Congenital stationary night blindness (HP:0007642)	2.77463996
20	Optic disc pallor (HP:0000543)	2.77435757
21	Abolished electroretinogram (ERG) (HP:0000550)	2.75220987
22	Hepatocellular necrosis (HP:0001404)	2.69858325
23	Pancreatic fibrosis (HP:0100732)	2.66366175
24	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.65183771
25	Lissencephaly (HP:0001339)	2.64744277
26	Cone-rod dystrophy (HP:0000548)	2.62754279
27	Attenuation of retinal blood vessels (HP:0007843)	2.59530655
28	Pancreatic cysts (HP:0001737)	2.57751366
29	Type 2 muscle fiber atrophy (HP:0003554)	2.56754467
30	Renal Fanconi syndrome (HP:0001994)	2.56608030
31	Macrocytic anemia (HP:0001972)	2.44760874
32	Cerebellar dysplasia (HP:0007033)	2.44496607
33	Hepatic necrosis (HP:0002605)	2.39193092
34	Abnormality of the renal cortex (HP:0011035)	2.38135802
35	Lactic acidosis (HP:0003128)	2.35734352
36	IgG deficiency (HP:0004315)	2.33030859
37	Congenital, generalized hypertrichosis (HP:0004540)	2.30946906
38	Reticulocytopenia (HP:0001896)	2.30088381
39	Renal cortical cysts (HP:0000803)	2.27272026
40	Lethargy (HP:0001254)	2.24665118
41	True hermaphroditism (HP:0010459)	2.23882074
42	Methylmalonic acidemia (HP:0002912)	2.23627439
43	3-Methylglutaconic aciduria (HP:0003535)	2.20095720
44	Increased muscle lipid content (HP:0009058)	2.19718841
45	Increased serum lactate (HP:0002151)	2.19554128
46	Abnormality of the labia minora (HP:0012880)	2.19099114
47	Respiratory failure (HP:0002878)	2.18643387
48	Elevated erythrocyte sedimentation rate (HP:0003565)	2.18373027
49	Degeneration of anterior horn cells (HP:0002398)	2.17706474
50	Abnormality of the anterior horn cell (HP:0006802)	2.17706474
51	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.17180583
52	Abnormality of cells of the erythroid lineage (HP:0012130)	2.16204939
53	Dyschromatopsia (HP:0007641)	2.14285173
54	Muscle fiber atrophy (HP:0100295)	2.13604055
55	Constricted visual fields (HP:0001133)	2.13182460
56	Bile duct proliferation (HP:0001408)	2.10802469
57	Abnormal biliary tract physiology (HP:0012439)	2.10802469
58	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.08445656
59	Abnormality of alanine metabolism (HP:0010916)	2.08445656
60	Hyperalaninemia (HP:0003348)	2.08445656
61	Colon cancer (HP:0003003)	2.07171274
62	Leukodystrophy (HP:0002415)	2.06823091
63	Abnormal drinking behavior (HP:0030082)	2.06548646
64	Polydipsia (HP:0001959)	2.06548646
65	Aplasia/hypoplasia of the uterus (HP:0008684)	2.04337781
66	Exertional dyspnea (HP:0002875)	1.99551401
67	Aplastic anemia (HP:0001915)	1.99171176
68	Anterior segment dysgenesis (HP:0007700)	1.97632857
69	Polyphagia (HP:0002591)	1.97591102
70	Abnormality of midbrain morphology (HP:0002418)	1.96340769
71	Molar tooth sign on MRI (HP:0002419)	1.96340769
72	Prostate neoplasm (HP:0100787)	1.94801266
73	Medial flaring of the eyebrow (HP:0010747)	1.94777558
74	Asplenia (HP:0001746)	1.93880907
75	Increased intramyocellular lipid droplets (HP:0012240)	1.93806461
76	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.89786083
77	Cleft eyelid (HP:0000625)	1.88861484
78	Testicular atrophy (HP:0000029)	1.86027900
79	Microvesicular hepatic steatosis (HP:0001414)	1.85306089
80	Agitation (HP:0000713)	1.85049676
81	Small hand (HP:0200055)	1.84076338
82	Abnormality of the prostate (HP:0008775)	1.82028246
83	Abnormal number of erythroid precursors (HP:0012131)	1.81052399
84	Exercise intolerance (HP:0003546)	1.80658605
85	Methylmalonic aciduria (HP:0012120)	1.80401208
86	Abnormality of urine glucose concentration (HP:0011016)	1.80297288
87	Glycosuria (HP:0003076)	1.80297288
88	Hyperglycinemia (HP:0002154)	1.79637142
89	Hypomagnesemia (HP:0002917)	1.77958657
90	Gaze-evoked nystagmus (HP:0000640)	1.77832640
91	Azoospermia (HP:0000027)	1.77315529
92	Abnormality of renal resorption (HP:0011038)	1.76115994
93	Nephronophthisis (HP:0000090)	1.74234094
94	Polyuria (HP:0000103)	1.70880790
95	Hypoplasia of the radius (HP:0002984)	1.69204686
96	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.68721071
97	Dicarboxylic aciduria (HP:0003215)	1.68721071
98	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.68579135
99	Increased IgM level (HP:0003496)	1.66927953
100	Fair hair (HP:0002286)	1.66839227

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.61703636
2	VRK2	3.58333498
3	NUAK1	3.52329860
4	NME2	3.35091403
5	TESK2	3.03971355
6	BCKDK	2.98400238
7	MAP4K1	2.56763278
8	TLK1	2.49224788
9	WNK4	2.45097078
10	GRK1	2.33543015
11	ADRBK2	2.30465257
12	TXK	2.26843564
13	ZAK	2.17176759
14	TIE1	1.91894800
15	TAF1	1.90051320
16	STK39	1.82011112
17	VRK1	1.80978502
18	PHKG2	1.69199876
19	PHKG1	1.69199876
20	MAP4K2	1.63702939
21	WNK3	1.56201460
22	MAPKAPK5	1.47950675
23	OXSR1	1.43146555
24	IKBKB	1.41018833
25	PINK1	1.34031808
26	ATR	1.30322648
27	FRK	1.28250142
28	BMPR1B	1.22944220
29	STK16	1.13692330
30	PBK	1.08539074
31	TEC	0.98704864
32	SRPK1	0.97257935
33	DAPK2	0.92532923
34	CDK19	0.92470587
35	PAK6	0.92399149
36	DYRK2	0.90485335
37	RPS6KA5	0.89536339
38	MAPK13	0.88893207
39	ITK	0.83838983
40	INSRR	0.83243266
41	PRKCQ	0.82020411
42	PIK3CA	0.80129222
43	PIK3CG	0.76687361
44	PRKCG	0.76327880
45	PLK4	0.75906582
46	MKNK1	0.73680475
47	PAK3	0.72410954
48	SCYL2	0.70791462
49	ADRBK1	0.69371721
50	BUB1	0.68203228
51	FES	0.67749067
52	CSNK2A2	0.67593516
53	TNK2	0.66963596
54	NME1	0.66157279
55	GRK6	0.65987510
56	CDC7	0.65983519
57	GRK5	0.64746232
58	CSNK1A1	0.63679815
59	SYK	0.62965047
60	KIT	0.62403819
61	CSNK2A1	0.60842101
62	PLK1	0.60061956
63	PRKACA	0.59000507
64	MAP3K4	0.58161541
65	PLK3	0.57973244
66	MST4	0.57214914
67	RPS6KA6	0.56993872
68	STK38L	0.55905748
69	CSNK1G3	0.55431057
70	AURKA	0.54935170
71	ABL2	0.54183482
72	CHUK	0.52775763
73	PRKCE	0.52426710
74	PLK2	0.51152907
75	EIF2AK1	0.46081235
76	MAP2K2	0.46018546
77	PRKCA	0.44928918
78	OBSCN	0.43664703
79	CDK4	0.43598782
80	ATM	0.42939929
81	CSNK1G2	0.42184277
82	PRKACG	0.41151154
83	EIF2AK2	0.40248095
84	MAP3K14	0.39368500
85	STK4	0.37828220
86	TRIM28	0.37438229
87	PRKG1	0.36861253
88	TNIK	0.36431086
89	PRKCI	0.36273634
90	CSNK1E	0.35282554
91	PASK	0.35109787
92	DAPK3	0.34801341
93	PDK2	0.34448535
94	MARK1	0.34230828
95	RPS6KB2	0.33971068
96	CAMK1	0.33422908
97	MKNK2	0.33289098
98	KDR	0.33245364
99	SMG1	0.33118050
100	RPS6KC1	0.32404046

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.26913512
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.44973845
3	Parkinsons disease_Homo sapiens_hsa05012	2.67806518
4	RNA polymerase_Homo sapiens_hsa03020	2.55471850
5	Proteasome_Homo sapiens_hsa03050	2.48402196
6	Asthma_Homo sapiens_hsa05310	2.43672673
7	Sulfur metabolism_Homo sapiens_hsa00920	2.33791956
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.31767401
9	Base excision repair_Homo sapiens_hsa03410	2.20112502
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.12059771
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.08843647
12	Protein export_Homo sapiens_hsa03060	2.01957111
13	Allograft rejection_Homo sapiens_hsa05330	1.98768928
14	Phototransduction_Homo sapiens_hsa04744	1.91353772
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.88929954
16	Basal transcription factors_Homo sapiens_hsa03022	1.81979982
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.78732868
18	DNA replication_Homo sapiens_hsa03030	1.78392127
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.77576381
20	Homologous recombination_Homo sapiens_hsa03440	1.77389833
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.73426861
22	RNA degradation_Homo sapiens_hsa03018	1.66371955
23	One carbon pool by folate_Homo sapiens_hsa00670	1.66348926
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.65933131
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.65442618
26	Huntingtons disease_Homo sapiens_hsa05016	1.65436859
27	Alzheimers disease_Homo sapiens_hsa05010	1.64985368
28	Mismatch repair_Homo sapiens_hsa03430	1.63163177
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.60660394
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.57491653
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.56585624
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.53972211
33	Graft-versus-host disease_Homo sapiens_hsa05332	1.51697721
34	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.51360875
35	Primary immunodeficiency_Homo sapiens_hsa05340	1.47888152
36	Type I diabetes mellitus_Homo sapiens_hsa04940	1.35544510
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.30702287
38	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.29779512
39	Caffeine metabolism_Homo sapiens_hsa00232	1.22916990
40	Collecting duct acid secretion_Homo sapiens_hsa04966	1.22643313
41	Peroxisome_Homo sapiens_hsa04146	1.21433831
42	Purine metabolism_Homo sapiens_hsa00230	1.20052504
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.10323294
44	Rheumatoid arthritis_Homo sapiens_hsa05323	1.05679543
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03713261
46	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.03549220
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.00005831
48	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.97762732
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.97376718
50	RNA transport_Homo sapiens_hsa03013	0.97211578
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.94237065
52	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.91840654
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.88819790
54	Antigen processing and presentation_Homo sapiens_hsa04612	0.85664304
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84446673
56	Ether lipid metabolism_Homo sapiens_hsa00565	0.84418937
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.81778366
58	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.78987045
59	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77368551
60	Retinol metabolism_Homo sapiens_hsa00830	0.73683021
61	Nicotine addiction_Homo sapiens_hsa05033	0.73316440
62	Propanoate metabolism_Homo sapiens_hsa00640	0.72670443
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.72404386
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.71042084
65	Metabolic pathways_Homo sapiens_hsa01100	0.67522648
66	Non-homologous end-joining_Homo sapiens_hsa03450	0.64213033
67	Spliceosome_Homo sapiens_hsa03040	0.63482026
68	ABC transporters_Homo sapiens_hsa02010	0.62903418
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61696287
70	Olfactory transduction_Homo sapiens_hsa04740	0.58143830
71	Sulfur relay system_Homo sapiens_hsa04122	0.55516591
72	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.54716789
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54199393
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53237740
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.51988123
76	mRNA surveillance pathway_Homo sapiens_hsa03015	0.51657467
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46996111
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44635578
79	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.44352721
80	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42919512
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.41665741
82	p53 signaling pathway_Homo sapiens_hsa04115	0.38298295
83	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.36112666
84	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.33562755
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33437322
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.33231187
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.33159680
88	Fatty acid degradation_Homo sapiens_hsa00071	0.28208334
89	Folate biosynthesis_Homo sapiens_hsa00790	0.26083248
90	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.23243859
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.23047526
92	Salivary secretion_Homo sapiens_hsa04970	0.23034652
93	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.22894258
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.21976973
95	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.21301140
96	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.21214105
97	Viral myocarditis_Homo sapiens_hsa05416	0.20552855
98	Glutathione metabolism_Homo sapiens_hsa00480	0.19088941
99	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.18638118
100	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.18576335

RPL19P20

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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