ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.62356417
2	behavioral response to nicotine (GO:0035095)	6.55305238
3	ribosomal small subunit biogenesis (GO:0042274)	6.47437207
4	viral transcription (GO:0019083)	6.35325458
5	translational termination (GO:0006415)	6.20430281
6	maturation of SSU-rRNA (GO:0030490)	5.22539975
7	translational elongation (GO:0006414)	5.19139679
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.16736145
9	cotranslational protein targeting to membrane (GO:0006613)	5.08212404
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.05986983
11	protein targeting to ER (GO:0045047)	5.05607761
12	ATP synthesis coupled proton transport (GO:0015986)	5.05233291
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.05233291
14	DNA deamination (GO:0045006)	4.88117442
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.81776277
16	protein localization to endoplasmic reticulum (GO:0070972)	4.77154764
17	cellular protein complex disassembly (GO:0043624)	4.65973258
18	negative regulation of telomere maintenance (GO:0032205)	4.61479455
19	viral life cycle (GO:0019058)	4.53386522
20	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.37604787
21	chaperone-mediated protein transport (GO:0072321)	4.36512591
22	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.10726366
23	translational initiation (GO:0006413)	4.00600074
24	protein neddylation (GO:0045116)	3.94305807
25	protein complex disassembly (GO:0043241)	3.89424926
26	water-soluble vitamin biosynthetic process (GO:0042364)	3.87341470
27	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.81906756
28	regulation of mitochondrial translation (GO:0070129)	3.81504504
29	L-fucose catabolic process (GO:0042355)	3.74105966
30	fucose catabolic process (GO:0019317)	3.74105966
31	L-fucose metabolic process (GO:0042354)	3.74105966
32	macromolecular complex disassembly (GO:0032984)	3.69451441
33	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.59636632
34	electron transport chain (GO:0022900)	3.59540888
35	ribosomal large subunit biogenesis (GO:0042273)	3.56520595
36	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.55342264
37	ncRNA 3-end processing (GO:0043628)	3.55186338
38	respiratory electron transport chain (GO:0022904)	3.50005175
39	translation (GO:0006412)	3.47467785
40	protein complex biogenesis (GO:0070271)	3.41558802
41	synaptic transmission, cholinergic (GO:0007271)	3.38086308
42	protein-cofactor linkage (GO:0018065)	3.38032211
43	ribonucleoprotein complex biogenesis (GO:0022613)	3.36114424
44	protein targeting to membrane (GO:0006612)	3.34081609
45	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.27600447
46	NADH dehydrogenase complex assembly (GO:0010257)	3.27600447
47	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.27600447
48	cellular component biogenesis (GO:0044085)	3.26628105
49	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.19793355
50	GTP biosynthetic process (GO:0006183)	3.15214406
51	intracellular protein transmembrane import (GO:0044743)	3.15096736
52	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.10482777
53	nonmotile primary cilium assembly (GO:0035058)	3.04993220
54	mitochondrial respiratory chain complex assembly (GO:0033108)	3.04455588
55	pyrimidine nucleotide catabolic process (GO:0006244)	3.01900605
56	rRNA catabolic process (GO:0016075)	2.96792741
57	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.93589768
58	mRNA catabolic process (GO:0006402)	2.93511804
59	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.92523351
60	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.92523351
61	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.92448411
62	rRNA metabolic process (GO:0016072)	2.91704581
63	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.89808527
64	rRNA processing (GO:0006364)	2.89149202
65	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.85964597
66	DNA strand renaturation (GO:0000733)	2.85558794
67	positive regulation of cell fate commitment (GO:0010455)	2.85544849
68	cellular ketone body metabolic process (GO:0046950)	2.85468470
69	ATP biosynthetic process (GO:0006754)	2.85259149
70	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.85196946
71	substrate-independent telencephalic tangential migration (GO:0021826)	2.85196946
72	positive regulation of defense response to virus by host (GO:0002230)	2.82938912
73	hydrogen ion transmembrane transport (GO:1902600)	2.82308051
74	regulation of memory T cell differentiation (GO:0043380)	2.81556922
75	base-excision repair, AP site formation (GO:0006285)	2.79935312
76	membrane repolarization during action potential (GO:0086011)	2.78666398
77	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.75382828
78	cytidine deamination (GO:0009972)	2.75138176
79	cytidine metabolic process (GO:0046087)	2.75138176
80	cytidine catabolic process (GO:0006216)	2.75138176
81	cellular response to ATP (GO:0071318)	2.73055214
82	epithelial cilium movement (GO:0003351)	2.71602294
83	positive regulation of T cell apoptotic process (GO:0070234)	2.69509189
84	relaxation of smooth muscle (GO:0044557)	2.68464571
85	proton transport (GO:0015992)	2.66050179
86	kynurenine metabolic process (GO:0070189)	2.65612014
87	RNA catabolic process (GO:0006401)	2.64371727
88	synapsis (GO:0007129)	2.64167322
89	regulation of cilium movement (GO:0003352)	2.63323825
90	cell proliferation in forebrain (GO:0021846)	2.62306743
91	pseudouridine synthesis (GO:0001522)	2.62253710
92	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.61576564
93	UTP biosynthetic process (GO:0006228)	2.61326645
94	positive regulation of fatty acid transport (GO:2000193)	2.60847197
95	hydrogen transport (GO:0006818)	2.58681499
96	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.57396875
97	motile cilium assembly (GO:0044458)	2.57310981
98	neurofilament cytoskeleton organization (GO:0060052)	2.55779100
99	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.55470278
100	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.55470278

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.02172385
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.45725477
3	VDR_22108803_ChIP-Seq_LS180_Human	3.29013526
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.17158644
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.91975368
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.76015126
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.73715878
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.42647543
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.39566775
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.38090452
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.35616228
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.28263378
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.20729318
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.20682749
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.15695538
16	IRF1_19129219_ChIP-ChIP_H3396_Human	2.14749493
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.08796510
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.06315891
19	EWS_26573619_Chip-Seq_HEK293_Human	1.86351061
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.67948646
21	VDR_23849224_ChIP-Seq_CD4+_Human	1.67177366
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.64718922
23	REST_21632747_ChIP-Seq_MESCs_Mouse	1.53305741
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.50676045
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.50671062
26	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.50567419
27	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.50369163
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.47544686
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.47327949
30	TAF2_19829295_ChIP-Seq_ESCs_Human	1.46665305
31	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.45890268
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.44778873
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.42823250
34	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.42778771
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.42531245
36	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.40110545
37	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.37663705
38	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.36905261
39	NCOR_22424771_ChIP-Seq_293T_Human	1.34202876
40	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.33571649
41	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.32114548
42	NANOG_20526341_ChIP-Seq_ESCs_Human	1.31134389
43	ERA_21632823_ChIP-Seq_H3396_Human	1.29324047
44	GBX2_23144817_ChIP-Seq_PC3_Human	1.28439741
45	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27948688
46	FOXP3_21729870_ChIP-Seq_TREG_Human	1.26693143
47	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.24614980
48	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.23216389
49	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19521069
50	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.19346370
51	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.19034043
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.17626990
53	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.17010692
54	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.16972722
55	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.16207407
56	AR_20517297_ChIP-Seq_VCAP_Human	1.16013087
57	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.15722116
58	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.13787444
59	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.12439684
60	RNF2_27304074_Chip-Seq_NSC_Mouse	1.12289917
61	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.11800784
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11353128
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11353128
64	TTF2_22483619_ChIP-Seq_HELA_Human	1.09953161
65	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.08017843
66	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.07985571
67	MYC_19829295_ChIP-Seq_ESCs_Human	1.07456588
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06922052
69	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.06654354
70	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06581506
71	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.06171007
72	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.05879142
73	ER_23166858_ChIP-Seq_MCF-7_Human	1.03699996
74	ELK1_19687146_ChIP-ChIP_HELA_Human	1.03462577
75	CTCF_20526341_ChIP-Seq_ESCs_Human	1.03336621
76	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.03016943
77	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.02671634
78	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02182066
79	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.02172747
80	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.01308053
81	GABP_19822575_ChIP-Seq_HepG2_Human	1.01272318
82	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.01149647
83	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.01087247
84	P53_21459846_ChIP-Seq_SAOS-2_Human	1.00139762
85	XRN2_22483619_ChIP-Seq_HELA_Human	0.99443036
86	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.99240612
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99174392
88	OCT4_20526341_ChIP-Seq_ESCs_Human	0.97698213
89	ERG_20517297_ChIP-Seq_VCAP_Human	0.97436209
90	RAC3_21632823_ChIP-Seq_H3396_Human	0.96393625
91	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.96380916
92	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.95992562
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95566475
94	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.95456869
95	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.93715106
96	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.92394077
97	P300_19829295_ChIP-Seq_ESCs_Human	0.92263583
98	BCAT_22108803_ChIP-Seq_LS180_Human	0.90632759
99	NANOG_19829295_ChIP-Seq_ESCs_Human	0.90096156
100	SOX2_19829295_ChIP-Seq_ESCs_Human	0.90096156

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.59797013
2	MP0006292_abnormal_olfactory_placode	3.96404387
3	MP0004885_abnormal_endolymph	2.89382729
4	MP0008875_abnormal_xenobiotic_pharmacok	2.75000526
5	MP0001968_abnormal_touch/_nociception	2.57625398
6	MP0005377_hearing/vestibular/ear_phenot	2.55576212
7	MP0003878_abnormal_ear_physiology	2.55576212
8	MP0002638_abnormal_pupillary_reflex	2.36335353
9	MP0008872_abnormal_physiological_respon	2.35873477
10	MP0004142_abnormal_muscle_tone	2.27988774
11	MP0002102_abnormal_ear_morphology	2.27882602
12	MP0004145_abnormal_muscle_electrophysio	2.25097049
13	MP0002653_abnormal_ependyma_morphology	2.11838430
14	MP0002138_abnormal_hepatobiliary_system	2.11817938
15	MP0001485_abnormal_pinna_reflex	2.05787864
16	MP0002736_abnormal_nociception_after	1.96808522
17	MP0008877_abnormal_DNA_methylation	1.81667966
18	MP0001986_abnormal_taste_sensitivity	1.66045233
19	MP0001984_abnormal_olfaction	1.65716924
20	MP0003136_yellow_coat_color	1.63973012
21	MP0005551_abnormal_eye_electrophysiolog	1.63715278
22	MP0002160_abnormal_reproductive_system	1.63435500
23	MP0005389_reproductive_system_phenotype	1.61512276
24	MP0006072_abnormal_retinal_apoptosis	1.60740040
25	MP0010386_abnormal_urinary_bladder	1.59566627
26	MP0003787_abnormal_imprinting	1.54878006
27	MP0002733_abnormal_thermal_nociception	1.54389263
28	MP0001873_stomach_inflammation	1.52303492
29	MP0005084_abnormal_gallbladder_morpholo	1.49783660
30	MP0009745_abnormal_behavioral_response	1.49146713
31	MP0002163_abnormal_gland_morphology	1.48046333
32	MP0005085_abnormal_gallbladder_physiolo	1.46777653
33	MP0003011_delayed_dark_adaptation	1.45596731
34	MP0003646_muscle_fatigue	1.45006912
35	MP0005360_urolithiasis	1.44367307
36	MP0009046_muscle_twitch	1.44207621
37	MP0002272_abnormal_nervous_system	1.43548310
38	MP0000049_abnormal_middle_ear	1.43514893
39	MP0004742_abnormal_vestibular_system	1.42430967
40	MP0003195_calcinosis	1.42286563
41	MP0001970_abnormal_pain_threshold	1.39180761
42	MP0000631_abnormal_neuroendocrine_gland	1.37010531
43	MP0002938_white_spotting	1.36008001
44	MP0002837_dystrophic_cardiac_calcinosis	1.33187167
45	MP0008789_abnormal_olfactory_epithelium	1.32965151
46	MP0003122_maternal_imprinting	1.32824167
47	MP0005646_abnormal_pituitary_gland	1.32497285
48	MP0006276_abnormal_autonomic_nervous	1.30620347
49	MP0002876_abnormal_thyroid_physiology	1.30337981
50	MP0001919_abnormal_reproductive_system	1.27458872
51	MP0005645_abnormal_hypothalamus_physiol	1.24250077
52	MP0005671_abnormal_response_to	1.23158628
53	MP0008058_abnormal_DNA_repair	1.18085466
54	MP0002735_abnormal_chemical_nociception	1.16660038
55	MP0001905_abnormal_dopamine_level	1.14164128
56	MP0001963_abnormal_hearing_physiology	1.13321000
57	MP0001486_abnormal_startle_reflex	1.12837407
58	MP0009697_abnormal_copulation	1.11375897
59	MP0003183_abnormal_peptide_metabolism	1.09456544
60	MP0005195_abnormal_posterior_eye	1.08503833
61	MP0000372_irregular_coat_pigmentation	1.07879707
62	MP0003186_abnormal_redox_activity	1.06498841
63	MP0001663_abnormal_digestive_system	1.06078723
64	MP0003879_abnormal_hair_cell	1.03427239
65	MP0002095_abnormal_skin_pigmentation	1.03367211
66	MP0000026_abnormal_inner_ear	1.01452418
67	MP0003806_abnormal_nucleotide_metabolis	1.01395914
68	MP0002184_abnormal_innervation	1.00741662
69	MP0004043_abnormal_pH_regulation	1.00715618
70	MP0005253_abnormal_eye_physiology	0.98928905
71	MP0003252_abnormal_bile_duct	0.97787795
72	MP0002064_seizures	0.97552292
73	MP0004147_increased_porphyrin_level	0.96745324
74	MP0002572_abnormal_emotion/affect_behav	0.95920875
75	MP0000230_abnormal_systemic_arterial	0.94641312
76	MP0002557_abnormal_social/conspecific_i	0.94405148
77	MP0003786_premature_aging	0.93782929
78	MP0001293_anophthalmia	0.93158269
79	MP0003693_abnormal_embryo_hatching	0.92836702
80	MP0005394_taste/olfaction_phenotype	0.91729054
81	MP0005499_abnormal_olfactory_system	0.91729054
82	MP0002752_abnormal_somatic_nervous	0.91214939
83	MP0000778_abnormal_nervous_system	0.90529035
84	MP0010030_abnormal_orbit_morphology	0.87125458
85	MP0005075_abnormal_melanosome_morpholog	0.86474560
86	MP0003635_abnormal_synaptic_transmissio	0.86389297
87	MP0000685_abnormal_immune_system	0.85798067
88	MP0003121_genomic_imprinting	0.85540694
89	MP0001502_abnormal_circadian_rhythm	0.84351510
90	MP0002234_abnormal_pharynx_morphology	0.83355872
91	MP0008995_early_reproductive_senescence	0.81931681
92	MP0002734_abnormal_mechanical_nocicepti	0.79903959
93	MP0005410_abnormal_fertilization	0.78807518
94	MP0002067_abnormal_sensory_capabilities	0.78102900
95	MP0001765_abnormal_ion_homeostasis	0.76792554
96	MP0001440_abnormal_grooming_behavior	0.76546150
97	MP0001529_abnormal_vocalization	0.75329298
98	MP0001501_abnormal_sleep_pattern	0.74384053
99	MP0003137_abnormal_impulse_conducting	0.73742363
100	MP0002063_abnormal_learning/memory/cond	0.73088389

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.13626688
2	Acute necrotizing encephalopathy (HP:0006965)	4.03396714
3	Pancreatic cysts (HP:0001737)	3.67886901
4	Abnormality of midbrain morphology (HP:0002418)	3.65531296
5	Molar tooth sign on MRI (HP:0002419)	3.65531296
6	Acute encephalopathy (HP:0006846)	3.57254039
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.57179272
8	Fibular aplasia (HP:0002990)	3.56489205
9	Pancreatic fibrosis (HP:0100732)	3.49583645
10	Abnormality of cells of the erythroid lineage (HP:0012130)	3.32438665
11	Mitochondrial inheritance (HP:0001427)	3.22601675
12	Progressive macrocephaly (HP:0004481)	3.18350603
13	Nephronophthisis (HP:0000090)	2.95457545
14	Fibular hypoplasia (HP:0003038)	2.95141374
15	Increased CSF lactate (HP:0002490)	2.94693926
16	Bilateral microphthalmos (HP:0007633)	2.93959731
17	True hermaphroditism (HP:0010459)	2.88616089
18	Colon cancer (HP:0003003)	2.87079753
19	Macrocytic anemia (HP:0001972)	2.84888298
20	Congenital stationary night blindness (HP:0007642)	2.83581059
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.78625490
22	Abnormal number of erythroid precursors (HP:0012131)	2.75114177
23	Pallor (HP:0000980)	2.73329759
24	Partial agenesis of the corpus callosum (HP:0001338)	2.72450567
25	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.66379006
26	Absent/shortened dynein arms (HP:0200106)	2.66379006
27	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.64050182
28	Absent thumb (HP:0009777)	2.60826808
29	Abnormality of the renal cortex (HP:0011035)	2.59295731
30	Asplenia (HP:0001746)	2.58497651
31	Cystic liver disease (HP:0006706)	2.58363685
32	Hepatocellular necrosis (HP:0001404)	2.57302812
33	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.56505681
34	Abnormality of the renal medulla (HP:0100957)	2.55906376
35	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.55449966
36	Hypoplasia of the fovea (HP:0007750)	2.55449966
37	Hepatic necrosis (HP:0002605)	2.53830026
38	Decreased central vision (HP:0007663)	2.49416142
39	Lipid accumulation in hepatocytes (HP:0006561)	2.45857543
40	Type II lissencephaly (HP:0007260)	2.45022073
41	Medial flaring of the eyebrow (HP:0010747)	2.42547834
42	Abnormality of alanine metabolism (HP:0010916)	2.39715257
43	Hyperalaninemia (HP:0003348)	2.39715257
44	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.39715257
45	Cerebral edema (HP:0002181)	2.37078652
46	Septo-optic dysplasia (HP:0100842)	2.35557616
47	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.35063718
48	Abolished electroretinogram (ERG) (HP:0000550)	2.34440515
49	Optic disc pallor (HP:0000543)	2.30962280
50	Tubular atrophy (HP:0000092)	2.25469218
51	Increased hepatocellular lipid droplets (HP:0006565)	2.21205132
52	Sclerocornea (HP:0000647)	2.18962458
53	Pendular nystagmus (HP:0012043)	2.16409280
54	Abnormality of DNA repair (HP:0003254)	2.11920755
55	3-Methylglutaconic aciduria (HP:0003535)	2.10428577
56	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.09151551
57	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.09071579
58	Thoracic kyphosis (HP:0002942)	2.08351356
59	Congenital, generalized hypertrichosis (HP:0004540)	2.07785183
60	Decreased circulating renin level (HP:0003351)	2.06506129
61	Abnormal respiratory epithelium morphology (HP:0012253)	2.03757088
62	Abnormal respiratory motile cilium morphology (HP:0005938)	2.03757088
63	Type 2 muscle fiber atrophy (HP:0003554)	2.03558441
64	Supernumerary spleens (HP:0009799)	1.99085617
65	Anencephaly (HP:0002323)	1.98333688
66	Oligodactyly (hands) (HP:0001180)	1.97486454
67	Gait imbalance (HP:0002141)	1.95658577
68	IgG deficiency (HP:0004315)	1.94707646
69	Abnormality of the fovea (HP:0000493)	1.92484224
70	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.91876074
71	Abnormal ciliary motility (HP:0012262)	1.91314741
72	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.90572574
73	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.90572574
74	Delayed CNS myelination (HP:0002188)	1.88904059
75	Flat capital femoral epiphysis (HP:0003370)	1.88880320
76	Increased serum lactate (HP:0002151)	1.88712450
77	Congenital primary aphakia (HP:0007707)	1.88525281
78	Brittle hair (HP:0002299)	1.87452927
79	Renal Fanconi syndrome (HP:0001994)	1.84350946
80	Adrenal hypoplasia (HP:0000835)	1.84321385
81	Methylmalonic acidemia (HP:0002912)	1.83751577
82	Abnormality of the anterior horn cell (HP:0006802)	1.82994056
83	Degeneration of anterior horn cells (HP:0002398)	1.82994056
84	Lactic acidosis (HP:0003128)	1.82135746
85	Abnormal drinking behavior (HP:0030082)	1.81739374
86	Polydipsia (HP:0001959)	1.81739374
87	Respiratory failure (HP:0002878)	1.81283282
88	Abnormal hemoglobin (HP:0011902)	1.78537252
89	Chronic hepatic failure (HP:0100626)	1.76225858
90	Attenuation of retinal blood vessels (HP:0007843)	1.74815484
91	Ectopic kidney (HP:0000086)	1.73418721
92	Rough bone trabeculation (HP:0100670)	1.72970808
93	Leukodystrophy (HP:0002415)	1.72401856
94	Lethargy (HP:0001254)	1.72354123
95	Increased intramyocellular lipid droplets (HP:0012240)	1.72255373
96	Muscle fiber atrophy (HP:0100295)	1.71891759
97	Asymmetry of the thorax (HP:0001555)	1.71763660
98	Postaxial foot polydactyly (HP:0001830)	1.70015889
99	Methylmalonic aciduria (HP:0012120)	1.69485601
100	Increased corneal curvature (HP:0100692)	1.69168781

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	4.21004273
2	VRK2	4.02851462
3	ADRBK2	3.32711832
4	ZAK	2.76247845
5	NUAK1	2.72807907
6	GRK1	2.69767445
7	TLK1	2.68136227
8	STK16	2.49384855
9	TAF1	2.34535278
10	PINK1	2.28933306
11	STK39	2.03283745
12	VRK1	1.99048013
13	FRK	1.97909060
14	DYRK2	1.96865435
15	BCKDK	1.68980063
16	TIE1	1.64873099
17	CAMKK2	1.46870328
18	MAP4K2	1.42916031
19	ITK	1.33573353
20	ADRBK1	1.33108872
21	MAPKAPK5	1.31887746
22	CDK19	1.31111237
23	PRKCG	1.29602403
24	PDK2	1.29169288
25	OXSR1	1.28976453
26	BMPR1B	1.28740397
27	WNK3	1.19793148
28	WNK1	1.19410509
29	TAOK3	1.17678641
30	STK11	1.15645059
31	MAP3K9	1.07591004
32	INSRR	1.07180269
33	PLK4	1.05123455
34	MAP3K4	1.04307021
35	PHKG2	1.04033756
36	PHKG1	1.04033756
37	PIK3CA	1.01261987
38	LRRK2	1.01185641
39	NME1	0.97910246
40	TXK	0.96411313
41	CDC7	0.95025542
42	MAPKAPK3	0.91954814
43	AKT3	0.90291783
44	PRKG2	0.89967973
45	PLK3	0.88232140
46	TNIK	0.88018771
47	CSNK1G3	0.86039404
48	MAP2K7	0.84948716
49	TEC	0.81978540
50	PRKCQ	0.79852742
51	CSNK1G2	0.79019699
52	CAMKK1	0.78716248
53	GRK5	0.77961686
54	MAPK13	0.77390830
55	RPS6KA5	0.74503549
56	NTRK2	0.71903305
57	MAP2K6	0.71773950
58	CSNK1G1	0.71637501
59	AURKA	0.71416169
60	CAMK1	0.67764867
61	DAPK3	0.66830624
62	BRAF	0.66590786
63	HIPK2	0.66579894
64	TYRO3	0.64500713
65	PLK2	0.64431335
66	PRKCE	0.62193589
67	BRSK2	0.61812606
68	KDR	0.61310796
69	PRKACA	0.61060274
70	IKBKB	0.60615137
71	CSNK1A1L	0.59613128
72	AURKB	0.58846675
73	PRKCA	0.55480137
74	LIMK1	0.53912655
75	PASK	0.53365622
76	PRKCI	0.53203364
77	CSNK2A2	0.51961158
78	DAPK2	0.49744793
79	CSNK1A1	0.49272846
80	SYK	0.49112078
81	PRKCD	0.48721894
82	ICK	0.46621842
83	CHEK2	0.46022835
84	ARAF	0.44885538
85	CASK	0.44792534
86	SMG1	0.42511843
87	CAMK2D	0.42248458
88	CSNK2A1	0.41906323
89	CAMK2A	0.41781023
90	DAPK1	0.41163970
91	TGFBR1	0.41023545
92	OBSCN	0.41018291
93	PLK1	0.38704828
94	ATR	0.37673136
95	PRKAA2	0.36188261
96	EPHA4	0.35858392
97	EPHB2	0.34492594
98	TNK2	0.34439290
99	CSNK1E	0.34195001
100	PRKG1	0.32684690

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.70299213
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.90941314
3	Parkinsons disease_Homo sapiens_hsa05012	3.33605285
4	Proteasome_Homo sapiens_hsa03050	2.43297206
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.27281122
6	Huntingtons disease_Homo sapiens_hsa05016	2.25883251
7	Alzheimers disease_Homo sapiens_hsa05010	2.14352090
8	RNA polymerase_Homo sapiens_hsa03020	2.13733635
9	Asthma_Homo sapiens_hsa05310	2.08291727
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.99999808
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.91227832
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.89848764
13	Protein export_Homo sapiens_hsa03060	1.86634998
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.78733583
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.69679110
16	Nucleotide excision repair_Homo sapiens_hsa03420	1.69043172
17	Homologous recombination_Homo sapiens_hsa03440	1.57846600
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.55510859
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.54766802
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.52234373
21	Allograft rejection_Homo sapiens_hsa05330	1.46370053
22	Mismatch repair_Homo sapiens_hsa03430	1.43655260
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.39791449
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.39007502
25	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.37275931
26	Basal transcription factors_Homo sapiens_hsa03022	1.36926438
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.36782789
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.36222040
29	RNA degradation_Homo sapiens_hsa03018	1.34133363
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.26194034
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.25375789
32	Phototransduction_Homo sapiens_hsa04744	1.24907155
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.23611408
34	One carbon pool by folate_Homo sapiens_hsa00670	1.23090503
35	Peroxisome_Homo sapiens_hsa04146	1.22126916
36	Butanoate metabolism_Homo sapiens_hsa00650	1.16431180
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.14369529
38	Primary immunodeficiency_Homo sapiens_hsa05340	1.12280511
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.07198550
40	Nicotine addiction_Homo sapiens_hsa05033	1.06732012
41	Graft-versus-host disease_Homo sapiens_hsa05332	1.05103259
42	Propanoate metabolism_Homo sapiens_hsa00640	1.02185252
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.00087308
44	DNA replication_Homo sapiens_hsa03030	0.99042518
45	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.98311835
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.95213162
47	Base excision repair_Homo sapiens_hsa03410	0.93629168
48	Caffeine metabolism_Homo sapiens_hsa00232	0.90290912
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89954848
50	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.86270651
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.84631140
52	Olfactory transduction_Homo sapiens_hsa04740	0.83158963
53	Type I diabetes mellitus_Homo sapiens_hsa04940	0.82505237
54	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.80984384
55	Sulfur relay system_Homo sapiens_hsa04122	0.77588992
56	Retinol metabolism_Homo sapiens_hsa00830	0.77140100
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.76653548
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76425071
59	Purine metabolism_Homo sapiens_hsa00230	0.76167913
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.74359220
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74160702
62	Metabolic pathways_Homo sapiens_hsa01100	0.74083337
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73957027
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.72827261
65	Morphine addiction_Homo sapiens_hsa05032	0.72798744
66	Rheumatoid arthritis_Homo sapiens_hsa05323	0.72638918
67	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.69969588
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.69029963
69	Sulfur metabolism_Homo sapiens_hsa00920	0.68422017
70	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.68174844
71	Selenocompound metabolism_Homo sapiens_hsa00450	0.67474848
72	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.65036575
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63849226
74	Fatty acid degradation_Homo sapiens_hsa00071	0.61977543
75	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.58871823
76	Pyruvate metabolism_Homo sapiens_hsa00620	0.58518778
77	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.55969725
78	Circadian entrainment_Homo sapiens_hsa04713	0.54804081
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.54544899
80	RNA transport_Homo sapiens_hsa03013	0.54047077
81	GABAergic synapse_Homo sapiens_hsa04727	0.52271328
82	Serotonergic synapse_Homo sapiens_hsa04726	0.51042381
83	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50081659
84	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48718729
85	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.48563370
86	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.45833480
87	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.45795208
88	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.44780698
89	Glutamatergic synapse_Homo sapiens_hsa04724	0.44539761
90	Insulin secretion_Homo sapiens_hsa04911	0.43172455
91	Taste transduction_Homo sapiens_hsa04742	0.42225060
92	Regulation of autophagy_Homo sapiens_hsa04140	0.41699898
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41261672
94	Antigen processing and presentation_Homo sapiens_hsa04612	0.41106424
95	Collecting duct acid secretion_Homo sapiens_hsa04966	0.39231656
96	Basal cell carcinoma_Homo sapiens_hsa05217	0.37390704
97	Histidine metabolism_Homo sapiens_hsa00340	0.36088325
98	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.35474917
99	Salivary secretion_Homo sapiens_hsa04970	0.34528199
100	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.33561351

RPL19P21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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