RPL21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)9.82221749
2* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.91758963
3* translational elongation (GO:0006414)8.87793421
4* cotranslational protein targeting to membrane (GO:0006613)8.76714459
5* protein targeting to ER (GO:0045047)8.75016802
6* establishment of protein localization to endoplasmic reticulum (GO:0072599)8.36808965
7* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)8.21039749
8* cellular protein complex disassembly (GO:0043624)8.20445103
9maturation of SSU-rRNA (GO:0030490)8.18784377
10* protein localization to endoplasmic reticulum (GO:0070972)8.17890489
11* viral life cycle (GO:0019058)8.15592842
12* translational initiation (GO:0006413)7.58928921
13ribosomal large subunit biogenesis (GO:0042273)7.21228111
14* protein complex disassembly (GO:0043241)7.14822340
15* macromolecular complex disassembly (GO:0032984)6.68493869
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.00258085
17* protein targeting to membrane (GO:0006612)5.83127726
18respiratory electron transport chain (GO:0022904)5.82197255
19* nuclear-transcribed mRNA catabolic process (GO:0000956)5.78979314
20electron transport chain (GO:0022900)5.72296160
21* mRNA catabolic process (GO:0006402)5.50123123
22* translation (GO:0006412)5.29019574
23ribonucleoprotein complex biogenesis (GO:0022613)5.15246763
24* RNA catabolic process (GO:0006401)5.09640354
25chaperone-mediated protein transport (GO:0072321)4.92690120
26protein complex biogenesis (GO:0070271)4.87335468
27mitochondrial respiratory chain complex assembly (GO:0033108)4.59125744
28mitochondrial respiratory chain complex I assembly (GO:0032981)4.56354632
29NADH dehydrogenase complex assembly (GO:0010257)4.56354632
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.56354632
31protein neddylation (GO:0045116)4.44640835
32ATP biosynthetic process (GO:0006754)4.12527409
33rRNA processing (GO:0006364)4.07254543
34rRNA metabolic process (GO:0016072)3.93550841
35hydrogen ion transmembrane transport (GO:1902600)3.90985060
36* establishment of protein localization to membrane (GO:0090150)3.90981506
37formation of translation preinitiation complex (GO:0001731)3.86987696
38cellular component biogenesis (GO:0044085)3.86470062
39purine nucleoside triphosphate biosynthetic process (GO:0009145)3.79530065
40purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.79077303
41DNA deamination (GO:0045006)3.66866897
42inner mitochondrial membrane organization (GO:0007007)3.58201221
43* protein targeting (GO:0006605)3.57349557
44* establishment of protein localization to organelle (GO:0072594)3.55769423
45ncRNA 3-end processing (GO:0043628)3.49838014
46telomere maintenance via semi-conservative replication (GO:0032201)3.48824443
47proton transport (GO:0015992)3.47881885
48DNA strand elongation involved in DNA replication (GO:0006271)3.47574768
49hydrogen transport (GO:0006818)3.40239318
50respiratory chain complex IV assembly (GO:0008535)3.33118937
51ribonucleoside triphosphate biosynthetic process (GO:0009201)3.30597699
52DNA strand elongation (GO:0022616)3.28260959
53oxidative phosphorylation (GO:0006119)3.28056031
54cytochrome complex assembly (GO:0017004)3.27810627
55regulation of mitochondrial translation (GO:0070129)3.23873042
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.10499262
57intracellular protein transmembrane import (GO:0044743)3.08791229
58rRNA modification (GO:0000154)3.08206387
59negative regulation of RNA splicing (GO:0033119)3.07642271
60spliceosomal snRNP assembly (GO:0000387)3.05725065
61telomere maintenance via recombination (GO:0000722)3.02869452
62* protein localization to membrane (GO:0072657)3.01988099
63spliceosomal complex assembly (GO:0000245)3.01957512
64DNA unwinding involved in DNA replication (GO:0006268)2.99024592
65RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.93605147
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.93605147
67DNA replication initiation (GO:0006270)2.93279061
68establishment of integrated proviral latency (GO:0075713)2.92442932
69water-soluble vitamin biosynthetic process (GO:0042364)2.91499906
70nucleoside triphosphate biosynthetic process (GO:0009142)2.89790216
71termination of RNA polymerase III transcription (GO:0006386)2.89247740
72transcription elongation from RNA polymerase III promoter (GO:0006385)2.89247740
73protein targeting to mitochondrion (GO:0006626)2.87174989
74mitotic recombination (GO:0006312)2.86255131
75* cellular component disassembly (GO:0022411)2.86253584
76energy coupled proton transport, down electrochemical gradient (GO:0015985)2.85624172
77ATP synthesis coupled proton transport (GO:0015986)2.85624172
78purine nucleoside monophosphate biosynthetic process (GO:0009127)2.82799601
79purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.82799601
80pseudouridine synthesis (GO:0001522)2.82594080
81establishment of protein localization to mitochondrion (GO:0072655)2.82584974
82sequestering of actin monomers (GO:0042989)2.80572404
83GTP biosynthetic process (GO:0006183)2.80075600
84protein-cofactor linkage (GO:0018065)2.78778069
85protein localization to mitochondrion (GO:0070585)2.77327417
86UTP biosynthetic process (GO:0006228)2.76994689
87telomere maintenance via telomere lengthening (GO:0010833)2.73065715
88ncRNA processing (GO:0034470)2.71746077
89histone exchange (GO:0043486)2.71433317
90mitochondrial transport (GO:0006839)2.71432360
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.69835858
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.67491512
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.67372568
94* protein localization to organelle (GO:0033365)2.65599533
95CENP-A containing nucleosome assembly (GO:0034080)2.64823426
96* gene expression (GO:0010467)2.63679876
97nucleotide-excision repair, DNA gap filling (GO:0006297)2.63124882
98regulation of mitotic spindle checkpoint (GO:1903504)2.61701597
99regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.61701597
100chromatin remodeling at centromere (GO:0031055)2.61610192
101DNA replication checkpoint (GO:0000076)2.60727223
102histone mRNA metabolic process (GO:0008334)2.60039307
103ribosome biogenesis (GO:0042254)2.60012599
104signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.55773414
105signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.55773414
106signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.55773414
107nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54060264
108DNA damage response, detection of DNA damage (GO:0042769)2.51202790
109signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.50723499
110intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.50723499
111rRNA methylation (GO:0031167)2.50578469
112ribonucleoprotein complex assembly (GO:0022618)2.50372172
113proteasome assembly (GO:0043248)2.49664663
114signal transduction involved in DNA integrity checkpoint (GO:0072401)2.48252154
115ncRNA metabolic process (GO:0034660)2.46236783
116kinetochore organization (GO:0051383)2.44259681
117deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.43688734
118termination of RNA polymerase II transcription (GO:0006369)2.42905523
119establishment of viral latency (GO:0019043)2.42165458
120RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.40962913
121mRNA splicing, via spliceosome (GO:0000398)2.40962913
122transcription-coupled nucleotide-excision repair (GO:0006283)2.40711331
123RNA splicing, via transesterification reactions (GO:0000375)2.40653890
124UTP metabolic process (GO:0046051)2.40312586
125negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.40241797
126pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.38555709
127CTP metabolic process (GO:0046036)2.38010718
128CTP biosynthetic process (GO:0006241)2.38010718
129DNA replication-independent nucleosome organization (GO:0034724)2.37779981
130DNA replication-independent nucleosome assembly (GO:0006336)2.37779981
131ribonucleoprotein complex subunit organization (GO:0071826)2.37284609
132pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.35461200
133DNA-templated transcription, termination (GO:0006353)2.35393241
134pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.32920790
135termination of RNA polymerase I transcription (GO:0006363)2.32322451
136definitive hemopoiesis (GO:0060216)2.31995557
137transcription elongation from RNA polymerase I promoter (GO:0006362)2.31816196
138negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.29646151
139establishment of protein localization to mitochondrial membrane (GO:0090151)2.26171058
140protein localization to kinetochore (GO:0034501)2.23828755
141DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.22904174
142guanosine-containing compound biosynthetic process (GO:1901070)2.22858769
143antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.22091897
144negative regulation of ligase activity (GO:0051352)2.21770822
145negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.21770822
146kinetochore assembly (GO:0051382)2.21570563
147* viral transcription (GO:0019083)11.0256015
148* translational termination (GO:0006415)10.5923107
149ribosomal small subunit assembly (GO:0000028)10.2067315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.43909448
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.97262094
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.85413290
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.09561191
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.71499050
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.35324766
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.23126729
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.08273799
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.04926769
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88265466
11XRN2_22483619_ChIP-Seq_HELA_Human2.85001789
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.84383630
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79802113
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.78406536
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.72446541
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68673327
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59301340
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48064205
19TTF2_22483619_ChIP-Seq_HELA_Human2.46580601
20* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45252239
21VDR_23849224_ChIP-Seq_CD4+_Human2.44895413
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.34719996
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29431995
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.28659712
25* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.28004650
26TP63_17297297_ChIP-ChIP_HaCaT_Human2.22801702
27ELK1_19687146_ChIP-ChIP_HELA_Human2.13221917
28* FOXP3_21729870_ChIP-Seq_TREG_Human2.10491412
29* DCP1A_22483619_ChIP-Seq_HELA_Human2.09908694
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06243516
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03709667
32EWS_26573619_Chip-Seq_HEK293_Human2.03205092
33FUS_26573619_Chip-Seq_HEK293_Human2.02584621
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93227561
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.92401492
36VDR_22108803_ChIP-Seq_LS180_Human1.89180937
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83504335
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81881877
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74851126
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71149397
41ZNF274_21170338_ChIP-Seq_K562_Hela1.68181259
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67095145
43* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66491181
44MYC_22102868_ChIP-Seq_BL_Human1.61679423
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.58378150
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58361985
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58154478
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56637721
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56394940
50* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55016271
51GABP_19822575_ChIP-Seq_HepG2_Human1.54198596
52ELK1_22589737_ChIP-Seq_MCF10A_Human1.52464968
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50544310
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49080884
55VDR_21846776_ChIP-Seq_THP-1_Human1.48999147
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.48377109
57* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.48008509
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47928418
59CIITA_25753668_ChIP-Seq_RAJI_Human1.46341733
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43345181
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40484476
62* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36316364
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33288577
64* MYC_18940864_ChIP-ChIP_HL60_Human1.33070970
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.31630049
66SPI1_23547873_ChIP-Seq_NB4_Human1.31528219
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.30346303
68TAF15_26573619_Chip-Seq_HEK293_Human1.29572188
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27815608
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24708899
71AR_21909140_ChIP-Seq_LNCAP_Human1.24183858
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23795270
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.23108442
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21178140
75* NANOG_16153702_ChIP-ChIP_HESCs_Human1.21109738
76SCL_19346495_ChIP-Seq_HPC-7_Human1.20801759
77* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19628913
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.19228486
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17826061
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16756385
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16098593
82P300_19829295_ChIP-Seq_ESCs_Human1.14560131
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13090050
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12746708
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12015178
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10685345
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10651968
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10075622
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09919621
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09545146
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09173755
92* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08787826
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07902121
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07596333
95* TP53_22573176_ChIP-Seq_HFKS_Human1.07341893
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.06614351
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05919054
98IGF1R_20145208_ChIP-Seq_DFB_Human1.05687715
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04900617
100IRF1_19129219_ChIP-ChIP_H3396_Human1.04140431
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02347506
102STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01464945
103PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00352663
104FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99959767
105FOXA1_25329375_ChIP-Seq_VCAP_Human0.99959767
106ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99186734
107* KDM5A_27292631_Chip-Seq_BREAST_Human0.99096148
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98916207
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98818925
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97394892
111ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97237139
112CBX2_27304074_Chip-Seq_ESCs_Mouse0.95851405
113TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95487332
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94921420
115SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94601211
116SALL1_21062744_ChIP-ChIP_HESCs_Human0.93685063
117SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93056096
118UTX_26944678_Chip-Seq_JUKART_Human0.92854519
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92459859
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.92349327
121SOX2_19829295_ChIP-Seq_ESCs_Human0.90320060
122NANOG_19829295_ChIP-Seq_ESCs_Human0.90320060
123NFE2_27457419_Chip-Seq_LIVER_Mouse0.90142292
124MAF_26560356_Chip-Seq_TH1_Human0.89816665
125* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89619396
126RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88961489
127MAF_26560356_Chip-Seq_TH2_Human0.88919580
128SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88480875
129PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88172071
130AR_20517297_ChIP-Seq_VCAP_Human0.87776448
131GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87346150
132ERG_20517297_ChIP-Seq_VCAP_Human0.86349375
133RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85129274
134* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85077200
135CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84840445
136VDR_24763502_ChIP-Seq_THP-1_Human0.84282390
137BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83754668
138ER_23166858_ChIP-Seq_MCF-7_Human0.82792148
139CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81817193
140CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79440267
141CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.77171598
142EZH2_22144423_ChIP-Seq_EOC_Human0.75846941

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.58530545
2MP0003693_abnormal_embryo_hatching3.61304587
3MP0004957_abnormal_blastocyst_morpholog3.12554652
4MP0010094_abnormal_chromosome_stability2.85639955
5MP0006072_abnormal_retinal_apoptosis2.79217877
6MP0002396_abnormal_hematopoietic_system2.53214884
7MP0003077_abnormal_cell_cycle2.51498536
8MP0003111_abnormal_nucleus_morphology2.30252621
9MP0003806_abnormal_nucleotide_metabolis2.23209310
10MP0008057_abnormal_DNA_replication2.13516834
11MP0003011_delayed_dark_adaptation2.12836729
12MP0005174_abnormal_tail_pigmentation2.10442218
13MP0000490_abnormal_crypts_of2.09037840
14MP0008007_abnormal_cellular_replicative2.08404937
15MP0008877_abnormal_DNA_methylation2.01890192
16MP0003763_abnormal_thymus_physiology1.97037702
17MP0001529_abnormal_vocalization1.96359649
18MP0004142_abnormal_muscle_tone1.94481168
19MP0008058_abnormal_DNA_repair1.90941436
20MP0004808_abnormal_hematopoietic_stem1.89299392
21MP0001293_anophthalmia1.86912688
22MP0005084_abnormal_gallbladder_morpholo1.86448497
23MP0003786_premature_aging1.85921256
24MP0008932_abnormal_embryonic_tissue1.83363046
25MP0003941_abnormal_skin_development1.83233533
26MP0002837_dystrophic_cardiac_calcinosis1.79815306
27MP0003186_abnormal_redox_activity1.77850564
28MP0003283_abnormal_digestive_organ1.76531775
29MP0002166_altered_tumor_susceptibility1.74148196
30MP0002095_abnormal_skin_pigmentation1.71067174
31MP0000566_synostosis1.68106107
32MP0004381_abnormal_hair_follicle1.68028124
33MP0000631_abnormal_neuroendocrine_gland1.63507919
34MP0001485_abnormal_pinna_reflex1.61473021
35MP0002009_preneoplasia1.60708394
36MP0009333_abnormal_splenocyte_physiolog1.57288670
37MP0002638_abnormal_pupillary_reflex1.56948623
38MP0002796_impaired_skin_barrier1.50661999
39MP0002398_abnormal_bone_marrow1.50457013
40MP0003136_yellow_coat_color1.50315010
41MP0001835_abnormal_antigen_presentation1.49716205
42MP0001545_abnormal_hematopoietic_system1.43879401
43MP0005397_hematopoietic_system_phenotyp1.43879401
44MP0000685_abnormal_immune_system1.42856409
45MP0003567_abnormal_fetal_cardiomyocyte1.42580402
46MP0002006_tumorigenesis1.41215297
47MP0000703_abnormal_thymus_morphology1.39415519
48MP0003315_abnormal_perineum_morphology1.38724733
49MP0000465_gastrointestinal_hemorrhage1.38362413
50MP0001800_abnormal_humoral_immune1.38340040
51MP0005253_abnormal_eye_physiology1.37504266
52MP0002132_abnormal_respiratory_system1.37122203
53MP0002722_abnormal_immune_system1.36697287
54MP0005501_abnormal_skin_physiology1.35158615
55MP0000350_abnormal_cell_proliferation1.34360599
56MP0005671_abnormal_response_to1.34313731
57MP0003890_abnormal_embryonic-extraembry1.33907816
58MP0005551_abnormal_eye_electrophysiolog1.32656323
59MP0006036_abnormal_mitochondrial_physio1.31996365
60MP0006054_spinal_hemorrhage1.31156368
61MP0005075_abnormal_melanosome_morpholog1.25032309
62MP0000689_abnormal_spleen_morphology1.23947595
63MP0001873_stomach_inflammation1.22968270
64MP0004133_heterotaxia1.22910010
65MP0002420_abnormal_adaptive_immunity1.22699440
66MP0008872_abnormal_physiological_respon1.22147201
67MP0005408_hypopigmentation1.22125441
68MP0001853_heart_inflammation1.21926720
69MP0005379_endocrine/exocrine_gland_phen1.21115947
70MP0001819_abnormal_immune_cell1.19554664
71MP0002019_abnormal_tumor_incidence1.18125382
72MP0002429_abnormal_blood_cell1.17723301
73MP0002452_abnormal_antigen_presenting1.17476579
74MP0008995_early_reproductive_senescence1.17462214
75MP0003718_maternal_effect1.17361217
76MP0010352_gastrointestinal_tract_polyps1.16971093
77MP0003724_increased_susceptibility_to1.16525704
78MP0008789_abnormal_olfactory_epithelium1.15917615
79MP0000716_abnormal_immune_system1.15604400
80MP0002148_abnormal_hypersensitivity_rea1.14358634
81MP0002163_abnormal_gland_morphology1.12682077
82MP0002277_abnormal_respiratory_mucosa1.12273159
83MP0001286_abnormal_eye_development1.11305816
84MP0010155_abnormal_intestine_physiology1.11070016
85MP0009785_altered_susceptibility_to1.10632800
86MP0003938_abnormal_ear_development1.10619375
87MP0005025_abnormal_response_to1.10461124
88MP0003787_abnormal_imprinting1.10134911
89MP0002723_abnormal_immune_serum1.09953146
90MP0004742_abnormal_vestibular_system1.08718802
91MP0003880_abnormal_central_pattern1.08428700
92MP0005389_reproductive_system_phenotype1.07186483
93MP0002160_abnormal_reproductive_system1.06373642
94MP0005000_abnormal_immune_tolerance1.06263362
95MP0003436_decreased_susceptibility_to1.05974793
96MP0002938_white_spotting1.05195470
97MP0000313_abnormal_cell_death1.04581195
98MP0001986_abnormal_taste_sensitivity1.04275944
99MP0003866_abnormal_defecation1.03996118
100MP0002405_respiratory_system_inflammati1.03893265
101MP0003123_paternal_imprinting1.02159256
102MP0001905_abnormal_dopamine_level1.01632964
103MP0002736_abnormal_nociception_after1.01031283
104MP0000858_altered_metastatic_potential0.99826560
105MP0001730_embryonic_growth_arrest0.99689558
106MP0002234_abnormal_pharynx_morphology0.99455543
107MP0005646_abnormal_pituitary_gland0.97373312
108MP0003878_abnormal_ear_physiology0.95192535
109MP0005377_hearing/vestibular/ear_phenot0.95192535
110MP0000569_abnormal_digit_pigmentation0.95134389
111MP0000372_irregular_coat_pigmentation0.95076518
112MP0009697_abnormal_copulation0.94877747
113MP0001216_abnormal_epidermal_layer0.93928825
114MP0005367_renal/urinary_system_phenotyp0.93051308
115MP0000516_abnormal_urinary_system0.93051308
116MP0003195_calcinosis0.92580218
117MP0010030_abnormal_orbit_morphology0.92355954
118MP0002928_abnormal_bile_duct0.91786910
119MP0006035_abnormal_mitochondrial_morpho0.91392031
120MP0005645_abnormal_hypothalamus_physiol0.90563779
121MP0002102_abnormal_ear_morphology0.88789930
122MP0001697_abnormal_embryo_size0.87059198
123MP0004885_abnormal_endolymph0.86912819
124MP0002098_abnormal_vibrissa_morphology0.86512574
125MP0002210_abnormal_sex_determination0.86320412
126MP0001790_abnormal_immune_system0.86116893
127MP0005387_immune_system_phenotype0.86116893
128MP0003937_abnormal_limbs/digits/tail_de0.86003476
129MP0001346_abnormal_lacrimal_gland0.85735080
130MP0003121_genomic_imprinting0.85703192
131MP0002060_abnormal_skin_morphology0.85534200
132MP0002080_prenatal_lethality0.84095889
133MP0000049_abnormal_middle_ear0.82263495
134MP0001968_abnormal_touch/_nociception0.81924866
135MP0002751_abnormal_autonomic_nervous0.81584174
136MP0005391_vision/eye_phenotype0.80495331
137MP0004147_increased_porphyrin_level0.79627411
138MP0000026_abnormal_inner_ear0.79592403
139MP0005195_abnormal_posterior_eye0.78114152
140MP0001984_abnormal_olfaction0.76738897
141MP0004019_abnormal_vitamin_homeostasis0.74534106
142MP0001145_abnormal_male_reproductive0.73500188
143MP0000383_abnormal_hair_follicle0.73089099
144MP0005409_darkened_coat_color0.73077358
145MP0010771_integument_phenotype0.72161021
146MP0006292_abnormal_olfactory_placode0.71646759
147MP0000477_abnormal_intestine_morphology0.71219610
148MP0008004_abnormal_stomach_pH0.70266516
149MP0008875_abnormal_xenobiotic_pharmacok0.70071727
150MP0001348_abnormal_lacrimal_gland0.69724417
151MP0000653_abnormal_sex_gland0.69620169
152MP0004145_abnormal_muscle_electrophysio0.69549464
153MP0000377_abnormal_hair_follicle0.69481628
154MP0009931_abnormal_skin_appearance0.69153298
155MP0002653_abnormal_ependyma_morphology0.68664950
156MP0003828_pulmonary_edema0.68618653
157MP0001324_abnormal_eye_pigmentation0.67588508
158MP0002085_abnormal_embryonic_tissue0.66629310
159MP0001663_abnormal_digestive_system0.66458844
160MP0001929_abnormal_gametogenesis0.65076904
161MP0005636_abnormal_mineral_homeostasis0.64918702
162MP0001919_abnormal_reproductive_system0.64497445
163MP0005023_abnormal_wound_healing0.64455382
164MP0000613_abnormal_salivary_gland0.64010171
165MP0002084_abnormal_developmental_patter0.63775933
166MP0010386_abnormal_urinary_bladder0.63292528
167MP0003119_abnormal_digestive_system0.62916920
168MP0002697_abnormal_eye_size0.62831116
169MP0002086_abnormal_extraembryonic_tissu0.61494768
170MP0002282_abnormal_trachea_morphology0.61260582
171MP0004947_skin_inflammation0.60866619
172MP0002272_abnormal_nervous_system0.60768447
173MP0005394_taste/olfaction_phenotype0.59459796

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)9.63023615
2Reticulocytopenia (HP:0001896)9.31163089
3Abnormal number of erythroid precursors (HP:0012131)8.47524506
4Macrocytic anemia (HP:0001972)6.74229849
5Pallor (HP:0000980)6.36198764
6Acute encephalopathy (HP:0006846)4.67507223
7Abnormal hemoglobin (HP:0011902)4.37726661
8Thrombocytosis (HP:0001894)4.03454058
9Aplasia/Hypoplasia of the sacrum (HP:0008517)3.85173923
10Aplastic anemia (HP:0001915)3.65338882
11Colon cancer (HP:0003003)3.46302909
12Cerebral edema (HP:0002181)3.41045441
13Increased hepatocellular lipid droplets (HP:0006565)3.22140718
14Septo-optic dysplasia (HP:0100842)3.14341539
15Abnormality of reticulocytes (HP:0004312)3.01409514
16Depressed nasal ridge (HP:0000457)3.01241474
17Absent thumb (HP:0009777)3.00990496
1811 pairs of ribs (HP:0000878)2.99538158
19Pancreatic cysts (HP:0001737)2.81377054
20Leukodystrophy (HP:0002415)2.79579428
21Exertional dyspnea (HP:0002875)2.79121589
22Abnormality of renal resorption (HP:0011038)2.75262807
23Optic disc pallor (HP:0000543)2.73241142
24Elevated erythrocyte sedimentation rate (HP:0003565)2.65908919
25IgM deficiency (HP:0002850)2.65614631
26Stenosis of the external auditory canal (HP:0000402)2.65319458
27Migraine (HP:0002076)2.63854368
28Lipid accumulation in hepatocytes (HP:0006561)2.63480473
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63390553
30Respiratory failure (HP:0002878)2.62748547
31Asplenia (HP:0001746)2.57823772
32Lactic acidosis (HP:0003128)2.56207075
33Oral leukoplakia (HP:0002745)2.53721006
34Pancreatic fibrosis (HP:0100732)2.53248068
35Mitochondrial inheritance (HP:0001427)2.50738569
36Methylmalonic acidemia (HP:0002912)2.49080168
37Thick lower lip vermilion (HP:0000179)2.46737987
38Molar tooth sign on MRI (HP:0002419)2.45494168
39Abnormality of midbrain morphology (HP:0002418)2.45494168
40Triphalangeal thumb (HP:0001199)2.41887121
41* Congenital, generalized hypertrichosis (HP:0004540)2.38626450
42Trismus (HP:0000211)2.38014551
43Aplasia/Hypoplasia of the spleen (HP:0010451)2.33856251
44Respiratory difficulties (HP:0002880)2.33658188
45Glycosuria (HP:0003076)2.31672172
46Abnormality of urine glucose concentration (HP:0011016)2.31672172
47True hermaphroditism (HP:0010459)2.31058469
48Hypoplasia of the radius (HP:0002984)2.29562499
49Renal Fanconi syndrome (HP:0001994)2.26927789
50Hepatocellular necrosis (HP:0001404)2.26899186
51Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25692415
52Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25692415
53Acute necrotizing encephalopathy (HP:0006965)2.22527543
54Hypothermia (HP:0002045)2.20649597
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.19145390
56Hyperphosphaturia (HP:0003109)2.18327776
57Myelodysplasia (HP:0002863)2.14194427
58Increased intramyocellular lipid droplets (HP:0012240)2.13401899
59Abnormality of the pons (HP:0007361)2.12030276
60Nephronophthisis (HP:0000090)2.11980772
61Concave nail (HP:0001598)2.11056423
62Petechiae (HP:0000967)2.10372803
63Hypoplasia of the pons (HP:0012110)2.10003375
64Rough bone trabeculation (HP:0100670)2.06462222
65Chronic otitis media (HP:0000389)2.06381664
66Absent septum pellucidum (HP:0001331)2.05916562
67Abnormality of the preputium (HP:0100587)2.05104159
68Breast hypoplasia (HP:0003187)2.01991985
69Birth length less than 3rd percentile (HP:0003561)2.01444501
70Lethargy (HP:0001254)2.01244935
71Increased CSF lactate (HP:0002490)2.00218105
72Medial flaring of the eyebrow (HP:0010747)2.00159089
73Glossoptosis (HP:0000162)1.94517921
74Prolonged bleeding time (HP:0003010)1.93625934
75Abnormality of secondary sexual hair (HP:0009888)1.92761149
76Abnormality of the axillary hair (HP:0100134)1.92761149
77Abnormal mitochondria in muscle tissue (HP:0008316)1.91890369
78Methylmalonic aciduria (HP:0012120)1.91610414
79Sparse lateral eyebrow (HP:0005338)1.91357908
80Abnormality of the heme biosynthetic pathway (HP:0010472)1.90611190
81Selective tooth agenesis (HP:0001592)1.90535781
82Cleft eyelid (HP:0000625)1.89865155
83Congenital stationary night blindness (HP:0007642)1.89458226
84Basal cell carcinoma (HP:0002671)1.88489620
85Sparse eyelashes (HP:0000653)1.88348900
86Pancytopenia (HP:0001876)1.87962281
87Bilateral microphthalmos (HP:0007633)1.86327504
88Multiple enchondromatosis (HP:0005701)1.86241680
89Recurrent bronchitis (HP:0002837)1.85411219
90Poikiloderma (HP:0001029)1.83563480
91Horseshoe kidney (HP:0000085)1.83407913
92Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82517453
93Partial duplication of the phalanx of hand (HP:0009999)1.82424834
94Abnormality of the septum pellucidum (HP:0007375)1.82196257
95Rib fusion (HP:0000902)1.81828355
96Maternal diabetes (HP:0009800)1.81796171
97Microretrognathia (HP:0000308)1.81592707
98Abnormality of methionine metabolism (HP:0010901)1.81380548
99Aplasia/Hypoplasia of the uvula (HP:0010293)1.80930105
100Fragile nails (HP:0001808)1.80469454
101Progressive macrocephaly (HP:0004481)1.77080150
102Sclerocornea (HP:0000647)1.76267637
103Neoplasm of the pancreas (HP:0002894)1.76190395
104Optic nerve hypoplasia (HP:0000609)1.76156667
105Megaloblastic anemia (HP:0001889)1.74981746
106Abnormality of the renal medulla (HP:0100957)1.73244506
107Atresia of the external auditory canal (HP:0000413)1.72506903
108Lymphoma (HP:0002665)1.72226492
109Partial duplication of thumb phalanx (HP:0009944)1.71396858
110Male pseudohermaphroditism (HP:0000037)1.71297890
111Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70884467
112Chromsome breakage (HP:0040012)1.70872928
113Premature graying of hair (HP:0002216)1.70591302
114Pili torti (HP:0003777)1.69445159
115Amniotic constriction ring (HP:0009775)1.68981265
116Abnormality of placental membranes (HP:0011409)1.68981265
117Entropion (HP:0000621)1.68390493
118Missing ribs (HP:0000921)1.67957910
119X-linked dominant inheritance (HP:0001423)1.67494261
120Aplasia/Hypoplasia of the thymus (HP:0010515)1.67185723
121Meckel diverticulum (HP:0002245)1.67121942
122Abnormality of the labia minora (HP:0012880)1.66885665
123Sparse scalp hair (HP:0002209)1.66131354
124Abnormality of the renal cortex (HP:0011035)1.65965249
125Hepatic necrosis (HP:0002605)1.65079481
126Increased muscle lipid content (HP:0009058)1.64080482
127Muscle fiber atrophy (HP:0100295)1.61913039
128Abnormality of the ileum (HP:0001549)1.60546825
1293-Methylglutaconic aciduria (HP:0003535)1.58383367
130Abnormality of the phalanges of the 2nd finger (HP:0009541)1.58283888
131Microvesicular hepatic steatosis (HP:0001414)1.58243377
132Abnormal rod and cone electroretinograms (HP:0008323)1.57722540
133Anophthalmia (HP:0000528)1.57618125
134Exercise intolerance (HP:0003546)1.57255983
135Panhypogammaglobulinemia (HP:0003139)1.56877454
136Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.56066687
137Abnormality of vitamin B metabolism (HP:0004340)1.55855297
138Secondary amenorrhea (HP:0000869)1.55680476
139Pulmonary fibrosis (HP:0002206)1.55315602
140Amaurosis fugax (HP:0100576)1.55109521
141Abnormal urine phosphate concentration (HP:0012599)1.54729725
142Congenital primary aphakia (HP:0007707)1.54408093
143CNS demyelination (HP:0007305)1.53902730
144Renal cortical cysts (HP:0000803)1.53477112
145Forearm undergrowth (HP:0009821)1.53446532
146Hyperglycinemia (HP:0002154)1.52803741
147Abnormal number of incisors (HP:0011064)1.52298393
148Abnormality of chromosome stability (HP:0003220)1.52237732
149Hyperinsulinemic hypoglycemia (HP:0000825)1.52186268
150Patellar aplasia (HP:0006443)1.52179080
151IgG deficiency (HP:0004315)1.51705189
152Type I transferrin isoform profile (HP:0003642)1.51118677
153Aplasia/hypoplasia of the uterus (HP:0008684)1.51072241
154Increased serum lactate (HP:0002151)1.50851318
155Carpal bone hypoplasia (HP:0001498)1.49623184
156Squamous cell carcinoma (HP:0002860)1.47948116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.60528906
2VRK24.52127359
3TLK14.33590026
4ZAK3.29643972
5WEE13.09819039
6BUB12.66058197
7RPS6KB22.60648763
8EIF2AK12.53463569
9TAF12.42827591
10VRK12.35167985
11TGFBR12.34483998
12SRPK12.33373014
13STK162.24292354
14LRRK22.22723116
15DYRK32.19495905
16CDC72.08663889
17PIM22.05821195
18MST42.04139598
19EEF2K1.99214825
20TNIK1.97758914
21MAP4K11.82787640
22WNK31.73803765
23MKNK11.73217053
24GRK11.67599885
25PNCK1.61503608
26CDK191.61173651
27PASK1.59870682
28ADRBK21.53913577
29DYRK21.53336743
30ACVR1B1.51532702
31RPS6KA41.45599601
32TEC1.43396563
33NME11.40823458
34NEK21.37758614
35MKNK21.36937192
36TSSK61.35266102
37CDK71.33835754
38MAP4K21.31875877
39INSRR1.27868406
40BTK1.27040618
41* AURKB1.25843883
42FRK1.22302683
43ILK1.22186154
44EIF2AK31.21703247
45WNK41.19109592
46OXSR11.17713167
47FLT31.13760450
48STK101.08089888
49MAPKAPK31.03496374
50GRK61.00467895
51BLK1.00294248
52PLK10.99256552
53PIM10.99108070
54KIT0.98105198
55BRSK20.96592563
56FGFR20.96232935
57CDK80.95140528
58STK390.93754298
59STK38L0.92575139
60NEK10.90062887
61RPS6KA50.89438982
62ATR0.89309179
63MAPK150.84632010
64CSNK2A20.83643714
65CDK40.82733693
66TAOK30.82671333
67STK240.81658714
68MAP3K80.79488002
69TESK20.78716555
70IKBKB0.77720335
71MAP3K110.77435423
72PAK40.77424980
73MAP3K100.76538846
74AURKA0.74059903
75KDR0.73551744
76MYLK0.71685356
77CDK60.70710806
78EPHB20.69652172
79ZAP700.69307207
80SYK0.68840593
81CDK30.67451591
82CSNK2A10.65994749
83SCYL20.64855779
84BMPR20.64266966
85DAPK30.63899004
86STK40.63506490
87STK30.63096663
88TTK0.62076803
89NLK0.61778124
90LCK0.59283133
91MAP3K120.58612919
92NUAK10.57974057
93NEK90.57907962
94MST1R0.57893616
95MAP2K30.57633036
96MAPKAPK50.57390949
97PKN20.56710205
98PINK10.56533705
99LYN0.56240168
100TGFBR20.56201470
101CLK10.55521926
102PLK40.55484305
103TYK20.55414819
104FES0.55201974
105PAK20.55098924
106EIF2AK20.54067093
107CDK90.53769477
108ADRBK10.53134147
109PBK0.52731660
110MAP2K20.51866240
111CHEK20.51350200
112PRKCG0.50615888
113MAP3K40.50298885
114DYRK1B0.48243905
115CHEK10.47257054
116MAP3K30.46872364
117CSF1R0.45147327
118BCKDK0.43972194
119JAK30.43879751
120TXK0.43647775
121ATM0.42945135
122IRAK40.42255111
123MUSK0.41582813
124TRIM280.41411794
125PLK30.41347438
126PAK10.41308967
127FGFR10.41226963
128PAK30.41216777
129TIE10.41158295
130BMPR1B0.40493121
131MAPK40.40357081
132TBK10.39983983
133MATK0.39696532
134CASK0.39286511
135ITK0.38816550
136CSNK1E0.36589774
137RPS6KC10.35202645
138RPS6KL10.35202645
139OBSCN0.33847400
140PRKACA0.32173799
141GRK70.29643963
142CSNK1A10.28862552
143PRKCE0.28199866
144CHUK0.27060298
145PRKCQ0.24609625

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030108.44949915
2DNA replication_Homo sapiens_hsa030303.76363399
3Mismatch repair_Homo sapiens_hsa034303.13039525
4RNA polymerase_Homo sapiens_hsa030203.09770886
5Spliceosome_Homo sapiens_hsa030403.00380310
6Proteasome_Homo sapiens_hsa030502.75198327
7Homologous recombination_Homo sapiens_hsa034402.45740960
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.45175152
9Nucleotide excision repair_Homo sapiens_hsa034202.29361574
10Pyrimidine metabolism_Homo sapiens_hsa002402.17275823
11Base excision repair_Homo sapiens_hsa034102.09147116
12RNA transport_Homo sapiens_hsa030132.03266965
13Protein export_Homo sapiens_hsa030601.77808929
14Oxidative phosphorylation_Homo sapiens_hsa001901.75201791
15Parkinsons disease_Homo sapiens_hsa050121.75076028
16Fanconi anemia pathway_Homo sapiens_hsa034601.62748337
17Non-homologous end-joining_Homo sapiens_hsa034501.61763506
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59624063
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.54511192
20Cell cycle_Homo sapiens_hsa041101.49284141
21RNA degradation_Homo sapiens_hsa030181.47156883
22Systemic lupus erythematosus_Homo sapiens_hsa053221.45477449
23One carbon pool by folate_Homo sapiens_hsa006701.45221464
24Huntingtons disease_Homo sapiens_hsa050161.40631310
25Basal transcription factors_Homo sapiens_hsa030221.37986894
26Primary immunodeficiency_Homo sapiens_hsa053401.34003431
27p53 signaling pathway_Homo sapiens_hsa041151.22352037
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16087548
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15819457
30Antigen processing and presentation_Homo sapiens_hsa046121.14167953
31Alzheimers disease_Homo sapiens_hsa050101.12459308
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06542795
33Purine metabolism_Homo sapiens_hsa002301.05490068
34Sulfur relay system_Homo sapiens_hsa041221.03197855
35Herpes simplex infection_Homo sapiens_hsa051681.02677822
36Epstein-Barr virus infection_Homo sapiens_hsa051691.01453771
37mRNA surveillance pathway_Homo sapiens_hsa030150.98915023
38Hematopoietic cell lineage_Homo sapiens_hsa046400.98150898
39Autoimmune thyroid disease_Homo sapiens_hsa053200.98011560
40Type I diabetes mellitus_Homo sapiens_hsa049400.97627637
41Phototransduction_Homo sapiens_hsa047440.85630115
42Cyanoamino acid metabolism_Homo sapiens_hsa004600.84535770
43Linoleic acid metabolism_Homo sapiens_hsa005910.83085919
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82011179
45Propanoate metabolism_Homo sapiens_hsa006400.76403217
46Viral carcinogenesis_Homo sapiens_hsa052030.72006270
47Vitamin digestion and absorption_Homo sapiens_hsa049770.68328105
48Folate biosynthesis_Homo sapiens_hsa007900.68275501
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67433897
50Caffeine metabolism_Homo sapiens_hsa002320.67400397
51Alcoholism_Homo sapiens_hsa050340.65964410
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.65627155
53HTLV-I infection_Homo sapiens_hsa051660.64197258
54Chemical carcinogenesis_Homo sapiens_hsa052040.63773196
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61889147
56Thyroid cancer_Homo sapiens_hsa052160.60884897
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60744933
58Nitrogen metabolism_Homo sapiens_hsa009100.60571943
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60210386
60Metabolic pathways_Homo sapiens_hsa011000.60199432
61Collecting duct acid secretion_Homo sapiens_hsa049660.60103615
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59750409
63Measles_Homo sapiens_hsa051620.58911390
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57284252
65Selenocompound metabolism_Homo sapiens_hsa004500.57060330
66Butanoate metabolism_Homo sapiens_hsa006500.56948533
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56883067
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55999380
69Tryptophan metabolism_Homo sapiens_hsa003800.55648827
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.55337460
71Regulation of autophagy_Homo sapiens_hsa041400.55294825
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51992556
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51404875
74Small cell lung cancer_Homo sapiens_hsa052220.51164715
75Hedgehog signaling pathway_Homo sapiens_hsa043400.50585432
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50287059
77Asthma_Homo sapiens_hsa053100.49052050
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.48755685
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48573396
80Sulfur metabolism_Homo sapiens_hsa009200.47645244
81B cell receptor signaling pathway_Homo sapiens_hsa046620.47264253
82Legionellosis_Homo sapiens_hsa051340.46724782
83Rheumatoid arthritis_Homo sapiens_hsa053230.45485682
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44910253
85Apoptosis_Homo sapiens_hsa042100.44664130
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.43865726
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43825040
88Pyruvate metabolism_Homo sapiens_hsa006200.43817464
89Hepatitis B_Homo sapiens_hsa051610.43646000
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43461652
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42954338
92Peroxisome_Homo sapiens_hsa041460.41905996
93Allograft rejection_Homo sapiens_hsa053300.41463733
94Arachidonic acid metabolism_Homo sapiens_hsa005900.40327223
95Acute myeloid leukemia_Homo sapiens_hsa052210.40159326
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39887069
97Leishmaniasis_Homo sapiens_hsa051400.39236006
98Retinol metabolism_Homo sapiens_hsa008300.37608208
99Basal cell carcinoma_Homo sapiens_hsa052170.37387349
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36730799
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36019774
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35051206
103N-Glycan biosynthesis_Homo sapiens_hsa005100.34303275
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34082144
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33856661
106Bladder cancer_Homo sapiens_hsa052190.32970751
107MicroRNAs in cancer_Homo sapiens_hsa052060.32716494
108Platelet activation_Homo sapiens_hsa046110.32500122
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.31962417
110Glutathione metabolism_Homo sapiens_hsa004800.31799708
111Shigellosis_Homo sapiens_hsa051310.31503576
112Malaria_Homo sapiens_hsa051440.31105286
113Pathways in cancer_Homo sapiens_hsa052000.30894390
114Graft-versus-host disease_Homo sapiens_hsa053320.29901919
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.29871876
116Notch signaling pathway_Homo sapiens_hsa043300.29536371
117Olfactory transduction_Homo sapiens_hsa047400.29351455
118T cell receptor signaling pathway_Homo sapiens_hsa046600.28975439
119Nicotine addiction_Homo sapiens_hsa050330.28762258
120Influenza A_Homo sapiens_hsa051640.28505937
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28211635
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.28174308
123Mineral absorption_Homo sapiens_hsa049780.28025608
124Cardiac muscle contraction_Homo sapiens_hsa042600.27937452
125Ether lipid metabolism_Homo sapiens_hsa005650.26619293
126Taste transduction_Homo sapiens_hsa047420.25616300
127TGF-beta signaling pathway_Homo sapiens_hsa043500.25479479
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25445460
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24974736
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24288101
131Pertussis_Homo sapiens_hsa051330.23184897
132Pentose phosphate pathway_Homo sapiens_hsa000300.23179230
133Chronic myeloid leukemia_Homo sapiens_hsa052200.22870420
134Fat digestion and absorption_Homo sapiens_hsa049750.22740089
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22370576
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22246450
137Toxoplasmosis_Homo sapiens_hsa051450.22227843
138HIF-1 signaling pathway_Homo sapiens_hsa040660.22077863
139Colorectal cancer_Homo sapiens_hsa052100.21300916
140Oocyte meiosis_Homo sapiens_hsa041140.21269016
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20666949
142Osteoclast differentiation_Homo sapiens_hsa043800.20077023
143Viral myocarditis_Homo sapiens_hsa054160.19474963
144Fatty acid elongation_Homo sapiens_hsa000620.19185763
145Other glycan degradation_Homo sapiens_hsa005110.17802792
146Wnt signaling pathway_Homo sapiens_hsa043100.14473305
147Tyrosine metabolism_Homo sapiens_hsa003500.13824339
148Primary bile acid biosynthesis_Homo sapiens_hsa001200.11505401

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