RPL21P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.16958532
2ribosomal small subunit assembly (GO:0000028)4.80003045
3water-soluble vitamin biosynthetic process (GO:0042364)4.55084583
4positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.51546678
5ATP synthesis coupled proton transport (GO:0015986)4.46169121
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.46169121
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.23502921
8protein complex biogenesis (GO:0070271)4.18378049
9mitochondrial respiratory chain complex I assembly (GO:0032981)4.05388821
10NADH dehydrogenase complex assembly (GO:0010257)4.05388821
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.05388821
12behavioral response to nicotine (GO:0035095)3.95730847
13regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.95398173
14mitochondrial respiratory chain complex assembly (GO:0033108)3.88420554
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.84986960
16nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.80006884
17respiratory chain complex IV assembly (GO:0008535)3.79002658
18exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.77769296
19regulation of immunoglobulin secretion (GO:0051023)3.66859972
20establishment of protein localization to mitochondrial membrane (GO:0090151)3.57104660
21protein neddylation (GO:0045116)3.43067246
22respiratory electron transport chain (GO:0022904)3.34896621
23electron transport chain (GO:0022900)3.34814577
24response to pheromone (GO:0019236)3.29493925
25tryptophan catabolic process (GO:0006569)3.28764772
26indole-containing compound catabolic process (GO:0042436)3.28764772
27indolalkylamine catabolic process (GO:0046218)3.28764772
28viral transcription (GO:0019083)3.28515989
29cytochrome complex assembly (GO:0017004)3.27591396
30regulation of isotype switching to IgG isotypes (GO:0048302)3.25113660
31translational termination (GO:0006415)3.22877464
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.22346576
33ribosomal large subunit biogenesis (GO:0042273)3.21219137
34proteasome assembly (GO:0043248)3.21092205
35cotranslational protein targeting to membrane (GO:0006613)3.19894306
36chaperone-mediated protein transport (GO:0072321)3.18590823
37protein targeting to ER (GO:0045047)3.13555452
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.13467986
39transcription elongation from RNA polymerase III promoter (GO:0006385)3.11214594
40termination of RNA polymerase III transcription (GO:0006386)3.11214594
41platelet dense granule organization (GO:0060155)3.05456418
42establishment of protein localization to endoplasmic reticulum (GO:0072599)3.01258178
43preassembly of GPI anchor in ER membrane (GO:0016254)3.00538611
44negative regulation of acute inflammatory response (GO:0002674)2.99398946
45protein localization to endoplasmic reticulum (GO:0070972)2.99367120
46regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.99077702
47axoneme assembly (GO:0035082)2.95101032
48protein-cofactor linkage (GO:0018065)2.93390851
49amine catabolic process (GO:0009310)2.85274931
50cellular biogenic amine catabolic process (GO:0042402)2.85274931
51translational elongation (GO:0006414)2.83253627
52hydrogen ion transmembrane transport (GO:1902600)2.83144986
53mannosylation (GO:0097502)2.80987409
54indolalkylamine metabolic process (GO:0006586)2.75469733
55L-fucose catabolic process (GO:0042355)2.73406834
56fucose catabolic process (GO:0019317)2.73406834
57L-fucose metabolic process (GO:0042354)2.73406834
58regulation of chronic inflammatory response (GO:0002676)2.72897366
59GPI anchor metabolic process (GO:0006505)2.72855073
60protein polyglutamylation (GO:0018095)2.72190296
61negative regulation of heart rate (GO:0010459)2.70977551
62synapsis (GO:0007129)2.70365048
63proton transport (GO:0015992)2.68889321
64interferon-gamma production (GO:0032609)2.66750170
65translation (GO:0006412)2.65919252
66tryptophan metabolic process (GO:0006568)2.65203358
67GTP biosynthetic process (GO:0006183)2.64918871
68hydrogen transport (GO:0006818)2.64632766
69kynurenine metabolic process (GO:0070189)2.63196503
70purine nucleoside triphosphate biosynthetic process (GO:0009145)2.62523114
71piRNA metabolic process (GO:0034587)2.62311620
72purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.61210074
73ATP biosynthetic process (GO:0006754)2.60038875
74RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59798992
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59798992
76positive regulation of respiratory burst (GO:0060267)2.58285295
77peptidyl-histidine modification (GO:0018202)2.57449942
78lactate metabolic process (GO:0006089)2.57267097
79somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.57024206
80isotype switching (GO:0045190)2.57024206
81somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.57024206
82S-adenosylmethionine metabolic process (GO:0046500)2.56480023
83maturation of SSU-rRNA (GO:0030490)2.56302098
84GPI anchor biosynthetic process (GO:0006506)2.55286828
85rRNA modification (GO:0000154)2.54438519
86retinal cone cell development (GO:0046549)2.52182566
87negative regulation of telomere maintenance (GO:0032205)2.52047592
88positive regulation of interleukin-17 production (GO:0032740)2.51123363
89detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.50399602
90aldehyde catabolic process (GO:0046185)2.49823807
91translational initiation (GO:0006413)2.49622520
92cellular ketone body metabolic process (GO:0046950)2.48097455
93cytidine deamination (GO:0009972)2.47244443
94cytidine metabolic process (GO:0046087)2.47244443
95cytidine catabolic process (GO:0006216)2.47244443
96intracellular protein transmembrane import (GO:0044743)2.46886992
97regulation of regulatory T cell differentiation (GO:0045589)2.44336188
98positive regulation of fatty acid transport (GO:2000193)2.43411395
99RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.39599203
100ketone body metabolic process (GO:1902224)2.38867657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.49627075
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.48661589
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12957754
4ZNF274_21170338_ChIP-Seq_K562_Hela3.05004711
5VDR_22108803_ChIP-Seq_LS180_Human3.03583740
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.81273663
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.80433307
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60831213
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53689646
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.46104768
11EWS_26573619_Chip-Seq_HEK293_Human2.26216784
12IGF1R_20145208_ChIP-Seq_DFB_Human2.22667563
13VDR_23849224_ChIP-Seq_CD4+_Human2.11390854
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04007868
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00530977
16ETS1_20019798_ChIP-Seq_JURKAT_Human1.99083616
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.91774898
18TP53_22573176_ChIP-Seq_HFKS_Human1.88055770
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87263466
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86202275
21FUS_26573619_Chip-Seq_HEK293_Human1.86053073
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85411925
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84603673
24ELK1_19687146_ChIP-ChIP_HELA_Human1.82672154
25MYC_18940864_ChIP-ChIP_HL60_Human1.81241048
26ER_23166858_ChIP-Seq_MCF-7_Human1.73693749
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68463018
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67284192
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.66653862
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63023353
31P300_19829295_ChIP-Seq_ESCs_Human1.60703766
32FOXA1_25329375_ChIP-Seq_VCAP_Human1.59398481
33FOXA1_27270436_Chip-Seq_PROSTATE_Human1.59398481
34GBX2_23144817_ChIP-Seq_PC3_Human1.59040622
35IRF1_19129219_ChIP-ChIP_H3396_Human1.58380610
36CBP_20019798_ChIP-Seq_JUKART_Human1.56230088
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56230088
38FOXP3_21729870_ChIP-Seq_TREG_Human1.53686995
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50951699
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47124197
41GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.46137199
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44741561
43AR_20517297_ChIP-Seq_VCAP_Human1.42562063
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42497301
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41075893
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.40105220
47SOX2_19829295_ChIP-Seq_ESCs_Human1.39250672
48NANOG_19829295_ChIP-Seq_ESCs_Human1.39250672
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37289181
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.34866134
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34482389
52EZH2_22144423_ChIP-Seq_EOC_Human1.32788181
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28879979
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.28709372
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27638910
56BCAT_22108803_ChIP-Seq_LS180_Human1.27544036
57TCF4_22108803_ChIP-Seq_LS180_Human1.26254082
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.25687056
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24858469
60TAF15_26573619_Chip-Seq_HEK293_Human1.23029142
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21510966
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18907005
63NCOR_22424771_ChIP-Seq_293T_Human1.16908635
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15942897
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15249671
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13453332
67IRF8_22096565_ChIP-ChIP_GC-B_Human1.12772814
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11903023
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08248035
70CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05791177
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.05781960
72GATA3_26560356_Chip-Seq_TH2_Human1.05004953
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03990454
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03956187
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03780534
76FOXH1_21741376_ChIP-Seq_EPCs_Human1.02245500
77HOXB7_26014856_ChIP-Seq_BT474_Human1.01967332
78TCF4_23295773_ChIP-Seq_U87_Human1.01928674
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.01346693
80MYC_19829295_ChIP-Seq_ESCs_Human1.00381150
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00360410
82TAF2_19829295_ChIP-Seq_ESCs_Human1.00244090
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99816048
84PIAS1_25552417_ChIP-Seq_VCAP_Human0.99276665
85CBX2_27304074_Chip-Seq_ESCs_Mouse0.98669594
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98588708
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98559469
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97907819
89PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97844846
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96812830
91TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96147131
92SMAD4_21799915_ChIP-Seq_A2780_Human0.96000122
93ERG_20517297_ChIP-Seq_VCAP_Human0.95857340
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95383547
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.94832837
96P53_22387025_ChIP-Seq_ESCs_Mouse0.94718619
97STAT3_23295773_ChIP-Seq_U87_Human0.93386710
98CDX2_22108803_ChIP-Seq_LS180_Human0.93022465
99TTF2_22483619_ChIP-Seq_HELA_Human0.91929406
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91892541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.06062835
2MP0002102_abnormal_ear_morphology2.84743696
3MP0003787_abnormal_imprinting2.68503232
4MP0001835_abnormal_antigen_presentation2.64871745
5MP0005075_abnormal_melanosome_morpholog2.50500570
6MP0002837_dystrophic_cardiac_calcinosis2.42875774
7MP0003195_calcinosis2.37063651
8MP0005646_abnormal_pituitary_gland2.27180241
9MP0000372_irregular_coat_pigmentation2.13338552
10MP0002876_abnormal_thyroid_physiology2.12711053
11MP0008872_abnormal_physiological_respon2.10442936
12MP0006072_abnormal_retinal_apoptosis1.99981110
13MP0006292_abnormal_olfactory_placode1.99473153
14MP0004142_abnormal_muscle_tone1.98716717
15MP0001986_abnormal_taste_sensitivity1.93130125
16MP0003646_muscle_fatigue1.89384258
17MP0002653_abnormal_ependyma_morphology1.88961491
18MP0002254_reproductive_system_inflammat1.88407898
19MP0005671_abnormal_response_to1.82289755
20MP0005551_abnormal_eye_electrophysiolog1.82051330
21MP0001873_stomach_inflammation1.79814622
22MP0001968_abnormal_touch/_nociception1.79317277
23MP0008875_abnormal_xenobiotic_pharmacok1.77941830
24MP0004147_increased_porphyrin_level1.69486562
25MP0009379_abnormal_foot_pigmentation1.67706538
26MP0002938_white_spotting1.67517459
27MP0003806_abnormal_nucleotide_metabolis1.64986254
28MP0001529_abnormal_vocalization1.60172518
29MP0000569_abnormal_digit_pigmentation1.59306789
30MP0003786_premature_aging1.54864557
31MP0005645_abnormal_hypothalamus_physiol1.42584158
32MP0005408_hypopigmentation1.40702953
33MP0002277_abnormal_respiratory_mucosa1.40306458
34MP0001348_abnormal_lacrimal_gland1.37069576
35MP0000685_abnormal_immune_system1.35247962
36MP0002163_abnormal_gland_morphology1.34357434
37MP0002736_abnormal_nociception_after1.34027167
38MP0005253_abnormal_eye_physiology1.33094066
39MP0005389_reproductive_system_phenotype1.33072336
40MP0002138_abnormal_hepatobiliary_system1.32444507
41MP0001440_abnormal_grooming_behavior1.32318335
42MP0003283_abnormal_digestive_organ1.31228403
43MP0005084_abnormal_gallbladder_morpholo1.30812127
44MP0004885_abnormal_endolymph1.30207659
45MP0006036_abnormal_mitochondrial_physio1.29219658
46MP0001984_abnormal_olfaction1.26889510
47MP0002638_abnormal_pupillary_reflex1.22442465
48MP0001919_abnormal_reproductive_system1.22007934
49MP0002272_abnormal_nervous_system1.21437681
50MP0002160_abnormal_reproductive_system1.19912495
51MP0005379_endocrine/exocrine_gland_phen1.18881083
52MP0008995_early_reproductive_senescence1.16329200
53MP0000427_abnormal_hair_cycle1.15744690
54MP0008789_abnormal_olfactory_epithelium1.14292332
55MP0005174_abnormal_tail_pigmentation1.11363655
56MP0002090_abnormal_vision1.08190694
57MP0000383_abnormal_hair_follicle1.07549700
58MP0006276_abnormal_autonomic_nervous1.06862081
59MP0004133_heterotaxia1.05046280
60MP0003878_abnormal_ear_physiology1.04828142
61MP0005377_hearing/vestibular/ear_phenot1.04828142
62MP0005367_renal/urinary_system_phenotyp1.03205521
63MP0000516_abnormal_urinary_system1.03205521
64MP0006035_abnormal_mitochondrial_morpho1.02114240
65MP0009745_abnormal_behavioral_response1.01440284
66MP0003121_genomic_imprinting0.99948094
67MP0001486_abnormal_startle_reflex0.98930277
68MP0002095_abnormal_skin_pigmentation0.98602394
69MP0001502_abnormal_circadian_rhythm0.98399552
70MP0008058_abnormal_DNA_repair0.96967211
71MP0001905_abnormal_dopamine_level0.96357443
72MP0001790_abnormal_immune_system0.95261093
73MP0005387_immune_system_phenotype0.95261093
74MP0001485_abnormal_pinna_reflex0.95209192
75MP0004145_abnormal_muscle_electrophysio0.94463000
76MP0001501_abnormal_sleep_pattern0.94408627
77MP0003011_delayed_dark_adaptation0.92022260
78MP0002693_abnormal_pancreas_physiology0.91256776
79MP0005636_abnormal_mineral_homeostasis0.91087047
80MP0003186_abnormal_redox_activity0.90726683
81MP0005332_abnormal_amino_acid0.89306240
82MP0000631_abnormal_neuroendocrine_gland0.87797346
83MP0003880_abnormal_central_pattern0.87304394
84MP0000613_abnormal_salivary_gland0.86182195
85MP0005670_abnormal_white_adipose0.86171125
86MP0005386_behavior/neurological_phenoty0.85263907
87MP0004924_abnormal_behavior0.85263907
88MP0009046_muscle_twitch0.84959683
89MP0009785_altered_susceptibility_to0.83481120
90MP0002557_abnormal_social/conspecific_i0.83452698
91MP0009697_abnormal_copulation0.81540080
92MP0004215_abnormal_myocardial_fiber0.79798368
93MP0005085_abnormal_gallbladder_physiolo0.79289632
94MP0005310_abnormal_salivary_gland0.78174556
95MP0003718_maternal_effect0.76728836
96MP0002234_abnormal_pharynx_morphology0.74468156
97MP0005195_abnormal_posterior_eye0.74346765
98MP0001800_abnormal_humoral_immune0.74047324
99MP0008775_abnormal_heart_ventricle0.72354347
100MP0009764_decreased_sensitivity_to0.71923492

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.68425481
2Acute encephalopathy (HP:0006846)4.13591764
3Progressive macrocephaly (HP:0004481)4.11436042
4Mitochondrial inheritance (HP:0001427)4.03089185
5Abnormal mitochondria in muscle tissue (HP:0008316)4.02247662
6Increased CSF lactate (HP:0002490)3.79758139
7Stomatitis (HP:0010280)3.73847658
8Congenital stationary night blindness (HP:0007642)3.70197146
9Pancreatic cysts (HP:0001737)3.67697991
10Abnormality of midbrain morphology (HP:0002418)3.45209585
11Molar tooth sign on MRI (HP:0002419)3.45209585
12Increased hepatocellular lipid droplets (HP:0006565)3.40396302
13Nephronophthisis (HP:0000090)3.25919033
14Lipid accumulation in hepatocytes (HP:0006561)3.25873695
15Congenital, generalized hypertrichosis (HP:0004540)3.20515886
16Hepatocellular necrosis (HP:0001404)3.18997025
173-Methylglutaconic aciduria (HP:0003535)3.04837244
18Cerebral edema (HP:0002181)3.04170945
19Methylmalonic acidemia (HP:0002912)2.97689040
20Pancreatic fibrosis (HP:0100732)2.90637598
21Hepatic necrosis (HP:0002605)2.79798733
22Type II lissencephaly (HP:0007260)2.78169469
23IgG deficiency (HP:0004315)2.65034412
24Aplasia/Hypoplasia of the spleen (HP:0010451)2.64519042
25Abnormal rod and cone electroretinograms (HP:0008323)2.64329947
26True hermaphroditism (HP:0010459)2.60016512
27Asplenia (HP:0001746)2.59025941
28Renal Fanconi syndrome (HP:0001994)2.56816827
29Medial flaring of the eyebrow (HP:0010747)2.56265883
30Optic disc pallor (HP:0000543)2.55049623
31Methylmalonic aciduria (HP:0012120)2.52375354
32Abnormality of the renal medulla (HP:0100957)2.48872747
33Pendular nystagmus (HP:0012043)2.44986828
34Aplasia/hypoplasia of the uterus (HP:0008684)2.44124711
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.42314065
36Exertional dyspnea (HP:0002875)2.40291859
37Increased serum lactate (HP:0002151)2.38343036
38Leukodystrophy (HP:0002415)2.31132080
39Lactic acidosis (HP:0003128)2.25497589
40Lethargy (HP:0001254)2.21802196
41Median cleft lip (HP:0000161)2.18624281
42Hyperinsulinemic hypoglycemia (HP:0000825)2.17969398
43Abnormality of the renal cortex (HP:0011035)2.15829540
44Attenuation of retinal blood vessels (HP:0007843)2.15590260
45Increased intramyocellular lipid droplets (HP:0012240)2.14537083
46Intestinal atresia (HP:0011100)2.12174185
47Hypomagnesemia (HP:0002917)2.11747871
48Ketosis (HP:0001946)2.09784504
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08856773
50Elevated erythrocyte sedimentation rate (HP:0003565)2.07237325
51Absent thumb (HP:0009777)2.03837251
52Aplasia/Hypoplasia of the fovea (HP:0008060)2.02248453
53Hypoplasia of the fovea (HP:0007750)2.02248453
54Abolished electroretinogram (ERG) (HP:0000550)2.02214173
55Abnormality of alanine metabolism (HP:0010916)2.01329516
56Hyperalaninemia (HP:0003348)2.01329516
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01329516
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00517121
59Hypothermia (HP:0002045)2.00475265
60Delayed CNS myelination (HP:0002188)2.00059930
61Respiratory failure (HP:0002878)1.99925317
62Ketoacidosis (HP:0001993)1.99196752
63Abnormal drinking behavior (HP:0030082)1.98613285
64Polydipsia (HP:0001959)1.98613285
65Cerebellar dysplasia (HP:0007033)1.98189836
66Constricted visual fields (HP:0001133)1.97778710
67Thyroiditis (HP:0100646)1.94988192
68Abnormality of renal resorption (HP:0011038)1.94915210
69Abnormality of B cell number (HP:0010975)1.94828200
70B lymphocytopenia (HP:0010976)1.93846802
71Sclerocornea (HP:0000647)1.93142183
72Hyperglycinemia (HP:0002154)1.90382719
73Reticulocytopenia (HP:0001896)1.89987571
74Glycosuria (HP:0003076)1.88709537
75Abnormality of urine glucose concentration (HP:0011016)1.88709537
76Hypoplasia of the uterus (HP:0000013)1.87402494
77Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86683237
78Increased muscle lipid content (HP:0009058)1.85224553
79Abnormality of vitamin B metabolism (HP:0004340)1.84675989
80Visual hallucinations (HP:0002367)1.82606544
81Aplasia/Hypoplasia of the ulna (HP:0006495)1.79741522
82Congenital hepatic fibrosis (HP:0002612)1.78845416
83Hypoplasia of the ulna (HP:0003022)1.76615382
84Respiratory difficulties (HP:0002880)1.76487097
85Hypoproteinemia (HP:0003075)1.76255373
86Male pseudohermaphroditism (HP:0000037)1.75127053
87Hyperphosphaturia (HP:0003109)1.75084537
88Cystic liver disease (HP:0006706)1.74922406
89Gait imbalance (HP:0002141)1.74585928
90Large for gestational age (HP:0001520)1.72950016
91Congenital primary aphakia (HP:0007707)1.72898312
92Optic nerve hypoplasia (HP:0000609)1.72110506
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71751082
94Exercise intolerance (HP:0003546)1.70854675
95Abnormality of the fovea (HP:0000493)1.70572515
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.69736342
97Adrenal hypoplasia (HP:0000835)1.69529587
98Polyuria (HP:0000103)1.69399519
99Tubular atrophy (HP:0000092)1.68195628
100Concave nail (HP:0001598)1.67842231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.17271982
2TAOK33.20653452
3NUAK13.01811173
4TXK2.88846652
5MAP4K22.62716087
6GRK12.58543433
7TRIM282.44140723
8BCKDK2.35773653
9ADRBK22.26278287
10WNK41.92855505
11TLK11.92742234
12ZAK1.92043786
13EIF2AK11.91534601
14STK391.72617016
15EIF2AK31.70767658
16OXSR11.69796402
17MAP4K11.67173345
18BMPR1B1.66843032
19WNK31.65435251
20ACVR1B1.61289370
21PINK11.59392417
22CDK191.57019202
23STK161.44919524
24MAP3K121.43302915
25PBK1.40925237
26AKT31.33329129
27TEC1.33116012
28TNIK1.31031758
29INSRR1.28670158
30MST41.16061263
31PAK31.15642105
32PHKG21.13046717
33PHKG11.13046717
34VRK21.10825231
35CASK1.10642275
36IKBKB1.08783619
37TIE11.01543863
38DYRK20.98403089
39CSNK1G20.97265622
40MAP2K60.96406166
41BRSK20.91160028
42GRK60.89840012
43NEK10.88916242
44PASK0.87412588
45PLK30.86861719
46STK38L0.86731723
47PRKCE0.83279148
48VRK10.82283640
49PRKCG0.81974039
50BMPR20.81078710
51MKNK10.80432409
52ITK0.80230070
53PLK20.79090928
54MYLK0.78835146
55CSNK1G30.78779603
56DAPK20.77499712
57KIT0.76195049
58CAMKK20.75401381
59CSNK1G10.74608151
60MKNK20.73232206
61MAP3K40.68459836
62FGFR20.67719532
63MAPK130.64395209
64CSNK1A1L0.63591460
65PIK3CG0.63578803
66LYN0.63556076
67ADRBK10.62235238
68EIF2AK20.61718773
69PLK40.61263151
70PDK20.58947163
71PIK3CA0.56973819
72FES0.54320877
73ERBB30.53836682
74PRKCQ0.53464489
75LCK0.50809957
76BTK0.50422740
77NTRK20.49885594
78PRKACA0.49863473
79SRPK10.49449091
80IRAK10.49116493
81SYK0.48941237
82STK30.47409862
83OBSCN0.47330625
84MAP2K70.46020892
85PRKCH0.45469759
86TSSK60.44543299
87CSNK2A20.43032036
88CSNK1A10.42726815
89IKBKE0.41456878
90RPS6KA50.40307320
91TGFBR10.39631695
92PRKG10.39565265
93PRKCA0.37424478
94CHUK0.36459165
95CSNK2A10.35220759
96SGK20.34500569
97CSF1R0.33945997
98IGF1R0.33208936
99CAMK2A0.32027371
100DAPK30.31794231

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.68632526
2Oxidative phosphorylation_Homo sapiens_hsa001903.29166586
3Ribosome_Homo sapiens_hsa030103.09370531
4Protein export_Homo sapiens_hsa030602.99097835
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.79889086
6Proteasome_Homo sapiens_hsa030502.71840710
7Allograft rejection_Homo sapiens_hsa053302.64528848
8Autoimmune thyroid disease_Homo sapiens_hsa053202.51307495
9Parkinsons disease_Homo sapiens_hsa050122.48728323
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.30440242
11RNA polymerase_Homo sapiens_hsa030202.25191029
12Type I diabetes mellitus_Homo sapiens_hsa049402.23420076
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.15527907
14Graft-versus-host disease_Homo sapiens_hsa053321.91203042
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84287243
16Linoleic acid metabolism_Homo sapiens_hsa005911.72967016
17Caffeine metabolism_Homo sapiens_hsa002321.68731320
18Alzheimers disease_Homo sapiens_hsa050101.65631997
19Huntingtons disease_Homo sapiens_hsa050161.65237748
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61533758
21Phototransduction_Homo sapiens_hsa047441.60463478
22Homologous recombination_Homo sapiens_hsa034401.53726908
23Primary immunodeficiency_Homo sapiens_hsa053401.52180679
24Propanoate metabolism_Homo sapiens_hsa006401.51467651
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49398972
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45054975
27RNA degradation_Homo sapiens_hsa030181.40944031
28Basal transcription factors_Homo sapiens_hsa030221.40233419
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39560291
30Cardiac muscle contraction_Homo sapiens_hsa042601.39549017
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29280180
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27888013
33Regulation of autophagy_Homo sapiens_hsa041401.19539841
34Fanconi anemia pathway_Homo sapiens_hsa034601.18999143
35Nitrogen metabolism_Homo sapiens_hsa009101.16506127
36Tryptophan metabolism_Homo sapiens_hsa003801.16210658
37Peroxisome_Homo sapiens_hsa041461.14927692
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08989276
39Butanoate metabolism_Homo sapiens_hsa006501.07396527
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03027153
41Vitamin B6 metabolism_Homo sapiens_hsa007501.02738202
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99500296
43Pyrimidine metabolism_Homo sapiens_hsa002400.97394681
44Chemical carcinogenesis_Homo sapiens_hsa052040.95817902
45Rheumatoid arthritis_Homo sapiens_hsa053230.95292392
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94810660
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94121621
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92784089
49Sulfur metabolism_Homo sapiens_hsa009200.92467857
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92409138
51Ether lipid metabolism_Homo sapiens_hsa005650.92050960
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91651809
53Nicotine addiction_Homo sapiens_hsa050330.89365529
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.89263871
55Antigen processing and presentation_Homo sapiens_hsa046120.88075189
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81345504
57Non-homologous end-joining_Homo sapiens_hsa034500.80971112
58Retinol metabolism_Homo sapiens_hsa008300.80215479
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.78761740
60Spliceosome_Homo sapiens_hsa030400.78256032
61Collecting duct acid secretion_Homo sapiens_hsa049660.77947253
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74669696
63Arachidonic acid metabolism_Homo sapiens_hsa005900.74399485
64Purine metabolism_Homo sapiens_hsa002300.73877373
65One carbon pool by folate_Homo sapiens_hsa006700.73663251
66Circadian rhythm_Homo sapiens_hsa047100.71731119
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68979326
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.68414656
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68369060
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66153512
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65846739
72Metabolic pathways_Homo sapiens_hsa011000.64147058
73Hematopoietic cell lineage_Homo sapiens_hsa046400.63544636
74RNA transport_Homo sapiens_hsa030130.62804228
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60882815
76Olfactory transduction_Homo sapiens_hsa047400.59842732
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58031790
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57946241
79Nucleotide excision repair_Homo sapiens_hsa034200.57132676
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.52203579
81Steroid biosynthesis_Homo sapiens_hsa001000.50882969
82Selenocompound metabolism_Homo sapiens_hsa004500.50108267
83Staphylococcus aureus infection_Homo sapiens_hsa051500.44963160
84Folate biosynthesis_Homo sapiens_hsa007900.44942081
85Insulin secretion_Homo sapiens_hsa049110.44574186
86Fat digestion and absorption_Homo sapiens_hsa049750.43933884
87beta-Alanine metabolism_Homo sapiens_hsa004100.43115337
88ABC transporters_Homo sapiens_hsa020100.40739363
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40178385
90Ovarian steroidogenesis_Homo sapiens_hsa049130.39702620
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39555818
92Vitamin digestion and absorption_Homo sapiens_hsa049770.37538846
93Fatty acid elongation_Homo sapiens_hsa000620.37532957
94Taste transduction_Homo sapiens_hsa047420.35958514
95Viral myocarditis_Homo sapiens_hsa054160.28682309
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28250830
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27503011
98Systemic lupus erythematosus_Homo sapiens_hsa053220.27418930
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26389897
100Fatty acid degradation_Homo sapiens_hsa000710.25957496

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