RPL21P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.10690546
2DNA deamination (GO:0045006)5.06394535
3ribosomal small subunit assembly (GO:0000028)4.58944518
4ATP synthesis coupled proton transport (GO:0015986)4.40163130
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.40163130
6RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.29798611
7tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.29798611
8viral transcription (GO:0019083)4.24485693
9translational termination (GO:0006415)4.12675208
10maturation of SSU-rRNA (GO:0030490)4.00647986
11detection of light stimulus involved in sensory perception (GO:0050962)3.85150888
12detection of light stimulus involved in visual perception (GO:0050908)3.85150888
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.74413907
14cotranslational protein targeting to membrane (GO:0006613)3.66936398
15protein targeting to ER (GO:0045047)3.66172109
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.61433535
17ribosomal small subunit biogenesis (GO:0042274)3.56536747
18protein complex biogenesis (GO:0070271)3.56479945
19piRNA metabolic process (GO:0034587)3.55937387
20translational elongation (GO:0006414)3.54890947
21water-soluble vitamin biosynthetic process (GO:0042364)3.54602084
22protein localization to endoplasmic reticulum (GO:0070972)3.54122634
23establishment of protein localization to endoplasmic reticulum (GO:0072599)3.50492323
24mitochondrial respiratory chain complex I assembly (GO:0032981)3.48997065
25NADH dehydrogenase complex assembly (GO:0010257)3.48997065
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.48997065
27regulation of cilium movement (GO:0003352)3.47522112
28fucose catabolic process (GO:0019317)3.45876822
29L-fucose metabolic process (GO:0042354)3.45876822
30L-fucose catabolic process (GO:0042355)3.45876822
31protein neddylation (GO:0045116)3.45008991
32chaperone-mediated protein transport (GO:0072321)3.42907777
33mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.41415928
34kynurenine metabolic process (GO:0070189)3.38422792
35nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.36100848
36mitochondrial respiratory chain complex assembly (GO:0033108)3.26793132
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19658581
38respiratory chain complex IV assembly (GO:0008535)3.12842046
39preassembly of GPI anchor in ER membrane (GO:0016254)3.11616359
40regulation of isotype switching to IgG isotypes (GO:0048302)3.04174115
41protein polyglutamylation (GO:0018095)3.02306606
42electron transport chain (GO:0022900)2.98933487
43respiratory electron transport chain (GO:0022904)2.96655183
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.96242760
45ribosomal large subunit biogenesis (GO:0042273)2.95806244
46cellular protein complex disassembly (GO:0043624)2.95090470
47axoneme assembly (GO:0035082)2.93279407
48cytochrome complex assembly (GO:0017004)2.92364295
49transcription elongation from RNA polymerase III promoter (GO:0006385)2.91219025
50termination of RNA polymerase III transcription (GO:0006386)2.91219025
51indolalkylamine catabolic process (GO:0046218)2.90881919
52tryptophan catabolic process (GO:0006569)2.90881919
53indole-containing compound catabolic process (GO:0042436)2.90881919
54viral life cycle (GO:0019058)2.89993315
55establishment of protein localization to mitochondrial membrane (GO:0090151)2.89552283
56GTP biosynthetic process (GO:0006183)2.89487554
57protein-cofactor linkage (GO:0018065)2.85419341
58translation (GO:0006412)2.84479832
59nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.83892623
60regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.82358364
61DNA methylation involved in gamete generation (GO:0043046)2.81600614
62negative regulation of telomere maintenance (GO:0032205)2.78985250
63cellular ketone body metabolic process (GO:0046950)2.77416794
64positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.76708324
65hydrogen ion transmembrane transport (GO:1902600)2.75532096
66translational initiation (GO:0006413)2.72876875
67purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.71335127
68purine nucleoside triphosphate biosynthetic process (GO:0009145)2.71205451
69nonmotile primary cilium assembly (GO:0035058)2.71060841
70base-excision repair, AP site formation (GO:0006285)2.70869970
71proton transport (GO:0015992)2.69868831
72tRNA processing (GO:0008033)2.69469657
73DNA double-strand break processing (GO:0000729)2.67856250
74RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.67762345
75ATP biosynthetic process (GO:0006754)2.65602782
76hydrogen transport (GO:0006818)2.65593851
77regulation of microtubule-based movement (GO:0060632)2.64870516
78indolalkylamine metabolic process (GO:0006586)2.62552057
79pseudouridine synthesis (GO:0001522)2.62456314
80cAMP catabolic process (GO:0006198)2.61366277
81rRNA catabolic process (GO:0016075)2.55983520
82regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.54362579
83regulation of immunoglobulin secretion (GO:0051023)2.53429885
84positive regulation of defense response to virus by host (GO:0002230)2.51740780
85regulation of action potential (GO:0098900)2.47924348
86regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.46795548
87regulation of mitotic spindle checkpoint (GO:1903504)2.46795548
88ketone body metabolic process (GO:1902224)2.46129259
89detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.46027196
90positive regulation of fatty acid transport (GO:2000193)2.45872818
91cellular component biogenesis (GO:0044085)2.45204321
92somite development (GO:0061053)2.44317071
93positive regulation of protein homooligomerization (GO:0032464)2.44184356
94protein localization to cilium (GO:0061512)2.44033083
95cytidine deamination (GO:0009972)2.41351906
96cytidine metabolic process (GO:0046087)2.41351906
97cytidine catabolic process (GO:0006216)2.41351906
98regulation of meiosis I (GO:0060631)2.41069828
99negative regulation of mast cell activation (GO:0033004)2.40403439
100protein complex disassembly (GO:0043241)2.39632519

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.32903012
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.19233236
3ZNF274_21170338_ChIP-Seq_K562_Hela3.12614759
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.88463000
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.87730087
6VDR_22108803_ChIP-Seq_LS180_Human2.80409857
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.65275637
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.60391646
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.57389387
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49941551
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.46821004
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16215740
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08122255
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06355913
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.04807092
16VDR_23849224_ChIP-Seq_CD4+_Human1.99029924
17IGF1R_20145208_ChIP-Seq_DFB_Human1.93849225
18TP53_22573176_ChIP-Seq_HFKS_Human1.90542100
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84890234
20NOTCH1_21737748_ChIP-Seq_TLL_Human1.83818274
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.81461024
22IRF1_19129219_ChIP-ChIP_H3396_Human1.71854024
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58033163
24EWS_26573619_Chip-Seq_HEK293_Human1.56483249
25FOXP3_21729870_ChIP-Seq_TREG_Human1.53162804
26MYC_18940864_ChIP-ChIP_HL60_Human1.52095230
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51193069
28GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.50812277
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.49442265
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49416989
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49059018
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47500179
33FUS_26573619_Chip-Seq_HEK293_Human1.46611793
34GBX2_23144817_ChIP-Seq_PC3_Human1.44137534
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41984888
36ELK1_19687146_ChIP-ChIP_HELA_Human1.40115814
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.38549107
38ER_23166858_ChIP-Seq_MCF-7_Human1.37674442
39P300_19829295_ChIP-Seq_ESCs_Human1.37431305
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35983880
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32542204
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32378630
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.32378630
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.29287713
45GATA3_21878914_ChIP-Seq_MCF-7_Human1.28678849
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26829603
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24678852
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24641224
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24298669
50REST_21632747_ChIP-Seq_MESCs_Mouse1.23546840
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22059890
52GATA3_26560356_Chip-Seq_TH2_Human1.20211395
53AR_20517297_ChIP-Seq_VCAP_Human1.20131214
54TAF2_19829295_ChIP-Seq_ESCs_Human1.19543243
55HOXB7_26014856_ChIP-Seq_BT474_Human1.18479065
56SOX2_19829295_ChIP-Seq_ESCs_Human1.17366855
57NANOG_19829295_ChIP-Seq_ESCs_Human1.17366855
58ERA_21632823_ChIP-Seq_H3396_Human1.14532431
59TTF2_22483619_ChIP-Seq_HELA_Human1.14501419
60CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14457427
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14424779
62NANOG_20526341_ChIP-Seq_ESCs_Human1.13760932
63NCOR_22424771_ChIP-Seq_293T_Human1.13674315
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13448114
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13205060
66MYC_19829295_ChIP-Seq_ESCs_Human1.13148519
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13144896
68BCAT_22108803_ChIP-Seq_LS180_Human1.12872654
69FOXH1_21741376_ChIP-Seq_EPCs_Human1.11801060
70AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11083430
71TCF4_22108803_ChIP-Seq_LS180_Human1.09470021
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07809390
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06836621
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06238920
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.05892142
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05669838
77TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01970103
78TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01481538
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01396125
80CBP_20019798_ChIP-Seq_JUKART_Human1.01396125
81TAF15_26573619_Chip-Seq_HEK293_Human1.01291242
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01024374
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00398353
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99179550
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96041714
86EZH2_27294783_Chip-Seq_NPCs_Mouse0.96015406
87FOXH1_21741376_ChIP-Seq_ESCs_Human0.95882421
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.95660943
89RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94714631
90CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94599154
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91820372
92STAT3_18555785_Chip-Seq_ESCs_Mouse0.91669860
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89223140
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88628820
95PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88195517
96RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87574097
97REST_18959480_ChIP-ChIP_MESCs_Mouse0.86449274
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86266555
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85987978
100GABP_19822575_ChIP-Seq_HepG2_Human0.85768021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.36215906
2MP0006292_abnormal_olfactory_placode3.15011148
3MP0009379_abnormal_foot_pigmentation3.14755965
4MP0004142_abnormal_muscle_tone2.52576251
5MP0008875_abnormal_xenobiotic_pharmacok2.44618297
6MP0005671_abnormal_response_to2.42954040
7MP0005551_abnormal_eye_electrophysiolog2.22043322
8MP0001835_abnormal_antigen_presentation2.14217162
9MP0005645_abnormal_hypothalamus_physiol2.04593034
10MP0006072_abnormal_retinal_apoptosis2.04519235
11MP0002876_abnormal_thyroid_physiology2.03604678
12MP0001968_abnormal_touch/_nociception1.97065128
13MP0008872_abnormal_physiological_respon1.94774028
14MP0005646_abnormal_pituitary_gland1.94465626
15MP0001986_abnormal_taste_sensitivity1.89060003
16MP0003195_calcinosis1.88612134
17MP0003646_muscle_fatigue1.88298920
18MP0002102_abnormal_ear_morphology1.82808259
19MP0002163_abnormal_gland_morphology1.81589839
20MP0003787_abnormal_imprinting1.80768734
21MP0004145_abnormal_muscle_electrophysio1.75643661
22MP0002138_abnormal_hepatobiliary_system1.74019265
23MP0002822_catalepsy1.72139147
24MP0004885_abnormal_endolymph1.65932017
25MP0004147_increased_porphyrin_level1.62821934
26MP0002736_abnormal_nociception_after1.60463511
27MP0002272_abnormal_nervous_system1.58111119
28MP0001873_stomach_inflammation1.55981180
29MP0002837_dystrophic_cardiac_calcinosis1.51912613
30MP0004742_abnormal_vestibular_system1.47341652
31MP0000685_abnormal_immune_system1.45812788
32MP0009745_abnormal_behavioral_response1.40344106
33MP0002638_abnormal_pupillary_reflex1.39427845
34MP0008789_abnormal_olfactory_epithelium1.39313821
35MP0001984_abnormal_olfaction1.38263706
36MP0003122_maternal_imprinting1.33039215
37MP0000569_abnormal_digit_pigmentation1.30587136
38MP0006276_abnormal_autonomic_nervous1.28939919
39MP0005174_abnormal_tail_pigmentation1.23738032
40MP0003806_abnormal_nucleotide_metabolis1.22530450
41MP0001905_abnormal_dopamine_level1.21606738
42MP0001800_abnormal_humoral_immune1.20636945
43MP0005389_reproductive_system_phenotype1.19200498
44MP0001529_abnormal_vocalization1.16804286
45MP0001970_abnormal_pain_threshold1.16771977
46MP0003186_abnormal_redox_activity1.15200694
47MP0005253_abnormal_eye_physiology1.14697420
48MP0001790_abnormal_immune_system1.14126197
49MP0005387_immune_system_phenotype1.14126197
50MP0001485_abnormal_pinna_reflex1.13154378
51MP0005379_endocrine/exocrine_gland_phen1.12299054
52MP0009046_muscle_twitch1.10661540
53MP0004043_abnormal_pH_regulation1.09074363
54MP0001501_abnormal_sleep_pattern1.08738440
55MP0003011_delayed_dark_adaptation1.08257597
56MP0002572_abnormal_emotion/affect_behav1.07875728
57MP0002160_abnormal_reproductive_system1.07417315
58MP0008058_abnormal_DNA_repair1.07398164
59MP0005423_abnormal_somatic_nervous1.06427154
60MP0002735_abnormal_chemical_nociception1.06415105
61MP0002733_abnormal_thermal_nociception1.05019231
62MP0005075_abnormal_melanosome_morpholog1.04065409
63MP0001440_abnormal_grooming_behavior1.03831427
64MP0001348_abnormal_lacrimal_gland1.02919324
65MP0006036_abnormal_mitochondrial_physio1.02210849
66MP0002557_abnormal_social/conspecific_i1.00998016
67MP0005394_taste/olfaction_phenotype1.00757276
68MP0005499_abnormal_olfactory_system1.00757276
69MP0002938_white_spotting0.99787196
70MP0000372_irregular_coat_pigmentation0.99560145
71MP0003786_premature_aging0.99137820
72MP0009764_decreased_sensitivity_to0.98623231
73MP0001486_abnormal_startle_reflex0.97728395
74MP0008775_abnormal_heart_ventricle0.97642803
75MP0002653_abnormal_ependyma_morphology0.96638007
76MP0009785_altered_susceptibility_to0.96531244
77MP0002234_abnormal_pharynx_morphology0.95929976
78MP0000427_abnormal_hair_cycle0.95649164
79MP0003121_genomic_imprinting0.95616734
80MP0001502_abnormal_circadian_rhythm0.94962306
81MP0005084_abnormal_gallbladder_morpholo0.94829989
82MP0006035_abnormal_mitochondrial_morpho0.94640102
83MP0002095_abnormal_skin_pigmentation0.94109909
84MP0005195_abnormal_posterior_eye0.93359897
85MP0001919_abnormal_reproductive_system0.91776326
86MP0002148_abnormal_hypersensitivity_rea0.90300718
87MP0008995_early_reproductive_senescence0.90003539
88MP0009333_abnormal_splenocyte_physiolog0.89823061
89MP0002184_abnormal_innervation0.87775142
90MP0004133_heterotaxia0.87311663
91MP0002229_neurodegeneration0.86596707
92MP0005377_hearing/vestibular/ear_phenot0.85118028
93MP0003878_abnormal_ear_physiology0.85118028
94MP0005000_abnormal_immune_tolerance0.83518714
95MP0000631_abnormal_neuroendocrine_gland0.82799032
96MP0002723_abnormal_immune_serum0.81668940
97MP0002693_abnormal_pancreas_physiology0.80853486
98MP0005167_abnormal_blood-brain_barrier0.80361623
99MP0003718_maternal_effect0.80360012
100MP0002063_abnormal_learning/memory/cond0.78776330

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.40547745
2Abnormal rod and cone electroretinograms (HP:0008323)4.60226584
3Abnormality of midbrain morphology (HP:0002418)4.15271595
4Molar tooth sign on MRI (HP:0002419)4.15271595
5Pancreatic cysts (HP:0001737)3.81433349
6Acute necrotizing encephalopathy (HP:0006965)3.76046817
7Aplasia/Hypoplasia of the fovea (HP:0008060)3.59536842
8Hypoplasia of the fovea (HP:0007750)3.59536842
9Reticulocytopenia (HP:0001896)3.45219881
10Pancreatic fibrosis (HP:0100732)3.42383869
11Mitochondrial inheritance (HP:0001427)3.41561015
12Nephronophthisis (HP:0000090)3.26553962
13Acute encephalopathy (HP:0006846)3.24471185
14Abnormal mitochondria in muscle tissue (HP:0008316)3.20379803
15Absent rod-and cone-mediated responses on ERG (HP:0007688)3.15930072
16Progressive macrocephaly (HP:0004481)3.13793405
17Increased CSF lactate (HP:0002490)3.11938756
18True hermaphroditism (HP:0010459)3.07582326
19Abnormality of macular pigmentation (HP:0008002)3.05677102
20Hepatocellular necrosis (HP:0001404)3.04064575
21IgG deficiency (HP:0004315)3.01900726
22Hepatic necrosis (HP:0002605)3.01481868
23Stomatitis (HP:0010280)2.96704417
24Abnormality of the fovea (HP:0000493)2.90180264
25Abnormality of the renal cortex (HP:0011035)2.84822852
26Central scotoma (HP:0000603)2.81528863
27Congenital, generalized hypertrichosis (HP:0004540)2.75771083
28Type II lissencephaly (HP:0007260)2.75390325
29Aplasia/Hypoplasia of the spleen (HP:0010451)2.73754141
30Severe visual impairment (HP:0001141)2.71415877
31Abnormality of the renal medulla (HP:0100957)2.68931789
32Abnormality of cells of the erythroid lineage (HP:0012130)2.67064871
33Renal cortical cysts (HP:0000803)2.65210201
34Asplenia (HP:0001746)2.63231367
35Pendular nystagmus (HP:0012043)2.62002972
36Lipid accumulation in hepatocytes (HP:0006561)2.51491274
37Abolished electroretinogram (ERG) (HP:0000550)2.48276506
38Medial flaring of the eyebrow (HP:0010747)2.44337912
39Increased hepatocellular lipid droplets (HP:0006565)2.44315271
40Decreased central vision (HP:0007663)2.40568991
41Optic disc pallor (HP:0000543)2.39642633
42Elevated erythrocyte sedimentation rate (HP:0003565)2.38442658
43Cystic liver disease (HP:0006706)2.30433617
44Attenuation of retinal blood vessels (HP:0007843)2.30154092
45Polydipsia (HP:0001959)2.29036559
46Abnormal drinking behavior (HP:0030082)2.29036559
47Hypomagnesemia (HP:0002917)2.28830040
48Cerebral edema (HP:0002181)2.25415917
49Colon cancer (HP:0003003)2.24233409
50Increased serum lactate (HP:0002151)2.19428394
51Macrocytic anemia (HP:0001972)2.19031207
52Abnormal number of erythroid precursors (HP:0012131)2.15271805
53Aplasia/Hypoplasia of the macula (HP:0008059)2.12908254
54Exertional dyspnea (HP:0002875)2.07857335
55Sclerocornea (HP:0000647)2.06265339
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05209114
573-Methylglutaconic aciduria (HP:0003535)2.01732032
58Aplasia/Hypoplasia affecting the retina (HP:0008061)2.01013336
59Albinism (HP:0001022)1.98098950
60Rib fusion (HP:0000902)1.98071176
61Polyuria (HP:0000103)1.95954201
62Keratoconus (HP:0000563)1.94091930
63Increased corneal curvature (HP:0100692)1.94091930
64Abnormality of magnesium homeostasis (HP:0004921)1.93707142
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93268033
66Constricted visual fields (HP:0001133)1.91136575
67Tubular atrophy (HP:0000092)1.88229785
68Absent thumb (HP:0009777)1.88064998
69Abnormality of the labia minora (HP:0012880)1.81737739
70Congenital hepatic fibrosis (HP:0002612)1.81104280
71Hypoplasia of the pons (HP:0012110)1.80483227
72Increased intramyocellular lipid droplets (HP:0012240)1.79664725
73Male pseudohermaphroditism (HP:0000037)1.79078318
74Postaxial foot polydactyly (HP:0001830)1.78687373
75Lactic acidosis (HP:0003128)1.78497671
76Progressive microcephaly (HP:0000253)1.77602830
77Gait imbalance (HP:0002141)1.77108108
78Scotoma (HP:0000575)1.77077467
79Chronic hepatic failure (HP:0100626)1.75716396
80Abnormal biliary tract physiology (HP:0012439)1.75298086
81Bile duct proliferation (HP:0001408)1.75298086
82Optic nerve hypoplasia (HP:0000609)1.74550787
83Abnormality of the pons (HP:0007361)1.74435124
84Respiratory failure (HP:0002878)1.73167991
85Anencephaly (HP:0002323)1.72785960
86Renal Fanconi syndrome (HP:0001994)1.72763213
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.72643381
88Glycosuria (HP:0003076)1.70572752
89Abnormality of urine glucose concentration (HP:0011016)1.70572752
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.70380348
91B lymphocytopenia (HP:0010976)1.70164711
92Congenital primary aphakia (HP:0007707)1.69656993
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68698288
94Abnormality of B cell number (HP:0010975)1.68175230
95Lethargy (HP:0001254)1.67582395
96Bony spicule pigmentary retinopathy (HP:0007737)1.66569816
97Leukodystrophy (HP:0002415)1.65058146
98Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.64100245
99Pallor (HP:0000980)1.63645901
100Recurrent cutaneous fungal infections (HP:0011370)1.63571329

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.70203958
2FRK3.63584552
3WNK43.02255537
4ADRBK22.79644832
5TLK12.79246932
6NUAK12.61556487
7TAOK32.54377088
8GRK12.45490664
9ZAK2.23691744
10MAP4K22.15761629
11PINK11.76340191
12DYRK21.75607827
13TIE11.70120064
14MAP3K121.68299294
15BCKDK1.63314862
16STK161.47836867
17WNK31.47432582
18MAP4K11.44984455
19TEC1.43387788
20PAK31.43365867
21STK391.42504276
22PIK3CA1.34534255
23OXSR11.33685094
24IKBKB1.21991351
25MAP2K61.21103534
26EIF2AK11.19381379
27ITK1.19281013
28PASK1.15667879
29MAPK131.10063188
30CSNK1G21.07848281
31PHKG11.07840247
32PHKG21.07840247
33CAMKK21.07312624
34NEK11.04324370
35CDK191.03489457
36MAP3K41.03484675
37NME11.03348308
38GRK71.01872002
39TNIK1.00281321
40TSSK60.97645597
41GRK60.97555549
42BMPR1B0.94481814
43INSRR0.91245974
44EIF2AK30.89908173
45CASK0.87409145
46CSNK1G30.86938636
47FES0.82773962
48VRK20.81832652
49SIK20.79898557
50SYK0.79715200
51DAPK20.79194213
52ADRBK10.78933132
53MAPKAPK30.77859399
54MST40.76869225
55ACVR1B0.76553132
56PRKCG0.73784067
57CAMK10.72469540
58PRKCQ0.72447807
59CSNK1A1L0.72323815
60TRIM280.70907470
61BTK0.70609102
62NTRK20.68032519
63PRKCE0.67687168
64VRK10.66747947
65LYN0.64821111
66PRKACA0.64573946
67KIT0.64510278
68CSNK1G10.62354554
69PLK20.61969338
70BMPR20.59810500
71CAMK2A0.57641388
72MAP3K110.56914168
73ATR0.56111129
74CAMK2D0.55451318
75LCK0.55216010
76CSF1R0.54820707
77RPS6KA50.52262795
78GRK50.51785968
79PTK2B0.51534523
80MYLK0.51492569
81ERBB30.51224451
82CSNK1A10.49183175
83WNK10.47572600
84DAPK10.46782892
85OBSCN0.46454049
86PNCK0.43887373
87CSNK2A20.43794043
88PRKG10.43270902
89PLK40.42812356
90PRKCA0.42519705
91MAP2K70.41939023
92CAMKK10.41337264
93RPS6KA60.39749327
94EIF2AK20.38340394
95MAP2K20.38031598
96TGFBR10.37682045
97IGF1R0.37616603
98DAPK30.37430384
99MKNK20.36249873
100PLK30.34299822

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.79146009
2Oxidative phosphorylation_Homo sapiens_hsa001903.21391263
3Asthma_Homo sapiens_hsa053102.86845338
4Parkinsons disease_Homo sapiens_hsa050122.53199254
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.44714748
6Protein export_Homo sapiens_hsa030602.39795917
7Allograft rejection_Homo sapiens_hsa053302.38361046
8RNA polymerase_Homo sapiens_hsa030202.27168004
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22737013
10Proteasome_Homo sapiens_hsa030502.21578779
11Autoimmune thyroid disease_Homo sapiens_hsa053202.19122247
12Cardiac muscle contraction_Homo sapiens_hsa042602.00556455
13Type I diabetes mellitus_Homo sapiens_hsa049401.99575122
14Linoleic acid metabolism_Homo sapiens_hsa005911.98179057
15Homologous recombination_Homo sapiens_hsa034401.93595689
16Caffeine metabolism_Homo sapiens_hsa002321.92769061
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88429218
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.84955999
19Graft-versus-host disease_Homo sapiens_hsa053321.76557833
20Alzheimers disease_Homo sapiens_hsa050101.76195738
21Primary immunodeficiency_Homo sapiens_hsa053401.75985818
22Phototransduction_Homo sapiens_hsa047441.70270432
23Huntingtons disease_Homo sapiens_hsa050161.68520883
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67611166
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61772364
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61407465
27RNA degradation_Homo sapiens_hsa030181.57692282
28Basal transcription factors_Homo sapiens_hsa030221.41627724
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41411105
30One carbon pool by folate_Homo sapiens_hsa006701.32625697
31Ether lipid metabolism_Homo sapiens_hsa005651.25518046
32Regulation of autophagy_Homo sapiens_hsa041401.24780852
33Nitrogen metabolism_Homo sapiens_hsa009101.21233804
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18401357
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16415558
36Fanconi anemia pathway_Homo sapiens_hsa034601.16330985
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16088480
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.15356088
39Nicotine addiction_Homo sapiens_hsa050331.10741470
40Butanoate metabolism_Homo sapiens_hsa006501.07676834
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99665678
42Rheumatoid arthritis_Homo sapiens_hsa053230.99439443
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99238426
44Pyrimidine metabolism_Homo sapiens_hsa002400.98785340
45Arachidonic acid metabolism_Homo sapiens_hsa005900.98651546
46Tryptophan metabolism_Homo sapiens_hsa003800.96093836
47Peroxisome_Homo sapiens_hsa041460.93506066
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92139147
49Propanoate metabolism_Homo sapiens_hsa006400.91489699
50Morphine addiction_Homo sapiens_hsa050320.90385511
51Mismatch repair_Homo sapiens_hsa034300.88907884
52Purine metabolism_Homo sapiens_hsa002300.86516029
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.85027833
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84545611
55Chemical carcinogenesis_Homo sapiens_hsa052040.82718782
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80522366
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.79613545
58Nucleotide excision repair_Homo sapiens_hsa034200.79308854
59Antigen processing and presentation_Homo sapiens_hsa046120.79176683
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75722872
61Sulfur relay system_Homo sapiens_hsa041220.74194670
62Insulin secretion_Homo sapiens_hsa049110.71136963
63Collecting duct acid secretion_Homo sapiens_hsa049660.68613839
64Olfactory transduction_Homo sapiens_hsa047400.67315339
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66594238
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.64451539
67RNA transport_Homo sapiens_hsa030130.63683781
68Fat digestion and absorption_Homo sapiens_hsa049750.63603234
69Fatty acid elongation_Homo sapiens_hsa000620.61955091
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.61448380
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61255737
72Retinol metabolism_Homo sapiens_hsa008300.61105073
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60098541
74Metabolic pathways_Homo sapiens_hsa011000.58771169
75Non-homologous end-joining_Homo sapiens_hsa034500.58516191
76GABAergic synapse_Homo sapiens_hsa047270.57464637
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.54563797
78Spliceosome_Homo sapiens_hsa030400.51813678
79Hematopoietic cell lineage_Homo sapiens_hsa046400.51402867
80DNA replication_Homo sapiens_hsa030300.50024686
81Serotonergic synapse_Homo sapiens_hsa047260.48800931
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48229717
83Vitamin B6 metabolism_Homo sapiens_hsa007500.44305608
84T cell receptor signaling pathway_Homo sapiens_hsa046600.43385153
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41145008
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40607483
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40365483
88Base excision repair_Homo sapiens_hsa034100.40129211
89Mineral absorption_Homo sapiens_hsa049780.40058241
90Ovarian steroidogenesis_Homo sapiens_hsa049130.38658614
91Salivary secretion_Homo sapiens_hsa049700.38203477
92Selenocompound metabolism_Homo sapiens_hsa004500.36253423
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34712925
94Folate biosynthesis_Homo sapiens_hsa007900.34439006
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33840387
96Taste transduction_Homo sapiens_hsa047420.30578087
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30119168
98beta-Alanine metabolism_Homo sapiens_hsa004100.28996435
99Viral myocarditis_Homo sapiens_hsa054160.26654595
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25443379

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