ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ATP synthesis coupled proton transport (GO:0015986)	5.00662127
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.00662127
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.00239822
4	ribosomal small subunit assembly (GO:0000028)	4.97313882
5	protein neddylation (GO:0045116)	4.75056510
6	viral transcription (GO:0019083)	4.66064483
7	DNA deamination (GO:0045006)	4.51927893
8	translational termination (GO:0006415)	4.44327640
9	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.25741887
10	cotranslational protein targeting to membrane (GO:0006613)	4.22648045
11	protein complex biogenesis (GO:0070271)	4.20590394
12	protein targeting to ER (GO:0045047)	4.17126560
13	positive regulation of tolerance induction (GO:0002645)	4.16211340
14	respiratory chain complex IV assembly (GO:0008535)	4.11172741
15	signal peptide processing (GO:0006465)	4.04307214
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.02938204
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.02081036
18	cytidine metabolic process (GO:0046087)	3.97698495
19	cytidine catabolic process (GO:0006216)	3.97698495
20	cytidine deamination (GO:0009972)	3.97698495
21	protein localization to endoplasmic reticulum (GO:0070972)	3.92242239
22	respiratory electron transport chain (GO:0022904)	3.89224071
23	regulation of T cell tolerance induction (GO:0002664)	3.88883868
24	electron transport chain (GO:0022900)	3.87270688
25	translational elongation (GO:0006414)	3.85862927
26	cytochrome complex assembly (GO:0017004)	3.77752627
27	mitochondrial respiratory chain complex assembly (GO:0033108)	3.73818296
28	regulation of isotype switching to IgG isotypes (GO:0048302)	3.66699763
29	positive T cell selection (GO:0043368)	3.56483205
30	maturation of SSU-rRNA (GO:0030490)	3.55716274
31	GTP biosynthetic process (GO:0006183)	3.55456299
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.49179872
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.49179872
34	NADH dehydrogenase complex assembly (GO:0010257)	3.49179872
35	positive regulation of interleukin-17 production (GO:0032740)	3.43520885
36	ribosomal small subunit biogenesis (GO:0042274)	3.40488145
37	water-soluble vitamin biosynthetic process (GO:0042364)	3.33328187
38	behavioral response to nicotine (GO:0035095)	3.31993170
39	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.28784447
40	viral life cycle (GO:0019058)	3.25978658
41	tryptophan catabolic process (GO:0006569)	3.25161775
42	indole-containing compound catabolic process (GO:0042436)	3.25161775
43	indolalkylamine catabolic process (GO:0046218)	3.25161775
44	cellular protein complex disassembly (GO:0043624)	3.25157815
45	regulation of tolerance induction (GO:0002643)	3.23225399
46	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.23152914
47	actin nucleation (GO:0045010)	3.18324079
48	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.17119705
49	translation (GO:0006412)	3.14142764
50	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.11911843
51	oxidative demethylation (GO:0070989)	3.10552877
52	lymphocyte costimulation (GO:0031294)	3.09642300
53	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.09168977
54	translational initiation (GO:0006413)	3.08699194
55	hydrogen ion transmembrane transport (GO:1902600)	3.05248518
56	negative T cell selection (GO:0043383)	3.04592907
57	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.04026769
58	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.01569577
59	T cell costimulation (GO:0031295)	3.01507890
60	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.99587681
61	regulation of regulatory T cell differentiation (GO:0045589)	2.98404476
62	kynurenine metabolic process (GO:0070189)	2.97155443
63	peptidyl-histidine modification (GO:0018202)	2.96767541
64	positive thymic T cell selection (GO:0045059)	2.95324231
65	UTP biosynthetic process (GO:0006228)	2.90776515
66	interferon-gamma production (GO:0032609)	2.87772712
67	indolalkylamine metabolic process (GO:0006586)	2.86946870
68	T cell receptor signaling pathway (GO:0050852)	2.86528179
69	positive regulation of calcium-mediated signaling (GO:0050850)	2.84199307
70	ATP biosynthetic process (GO:0006754)	2.81944960
71	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.81091160
72	proton transport (GO:0015992)	2.79138643
73	hydrogen transport (GO:0006818)	2.76707620
74	protein targeting to membrane (GO:0006612)	2.75862451
75	regulation of cellular amino acid metabolic process (GO:0006521)	2.73376083
76	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.69257319
77	proteasome assembly (GO:0043248)	2.68922199
78	regulation of chronic inflammatory response (GO:0002676)	2.68154562
79	UTP metabolic process (GO:0046051)	2.67769340
80	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.64041869
81	tryptophan metabolic process (GO:0006568)	2.59864851
82	activated T cell proliferation (GO:0050798)	2.59522691
83	protein complex disassembly (GO:0043241)	2.58913351
84	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.57692264
85	adenosine metabolic process (GO:0046085)	2.56104523
86	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.55001268
87	macromolecular complex disassembly (GO:0032984)	2.54876061
88	regulation of alpha-beta T cell proliferation (GO:0046640)	2.53993559
89	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.52491034
90	cytokine biosynthetic process (GO:0042089)	2.51409504
91	positive regulation of DNA recombination (GO:0045911)	2.50250184
92	cellular ketone body metabolic process (GO:0046950)	2.49727223
93	adaptation of signaling pathway (GO:0023058)	2.48539066
94	T cell differentiation involved in immune response (GO:0002292)	2.48509991
95	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.48509991
96	alpha-beta T cell activation involved in immune response (GO:0002287)	2.48509991
97	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.48482271
98	cellular biogenic amine catabolic process (GO:0042402)	2.47326870
99	amine catabolic process (GO:0009310)	2.47326870
100	cellular response to interleukin-15 (GO:0071350)	2.46252769

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.73678631
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.68426735
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.41351690
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.28029691
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.86699882
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.52619239
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.42453536
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.41154224
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.38780070
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.38353736
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.34799806
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.25753802
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.17124164
14	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.10792787
15	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.09335687
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.06567783
17	EZH2_22144423_ChIP-Seq_EOC_Human	2.05274564
18	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.01596567
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.94583684
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.88661718
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.85935694
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.79000216
23	EWS_26573619_Chip-Seq_HEK293_Human	1.77252533
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68376935
25	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.68051784
26	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.66896193
27	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.64327041
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.62022207
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.58457543
30	FOXP3_21729870_ChIP-Seq_TREG_Human	1.50998458
31	NANOG_19829295_ChIP-Seq_ESCs_Human	1.49677564
32	SOX2_19829295_ChIP-Seq_ESCs_Human	1.49677564
33	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.44130446
34	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.44130446
35	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.42505675
36	HTT_18923047_ChIP-ChIP_STHdh_Human	1.42328484
37	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.41391849
38	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.40163690
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.40074275
40	GATA3_26560356_Chip-Seq_TH2_Human	1.38467514
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.37017935
42	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.36105515
43	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.35845170
44	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.33286115
45	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.32533833
46	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.32394354
47	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.32134229
48	NCOR_22424771_ChIP-Seq_293T_Human	1.32082735
49	P300_19829295_ChIP-Seq_ESCs_Human	1.30785935
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.27846485
51	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27193541
52	MYB_26560356_Chip-Seq_TH2_Human	1.26674788
53	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.23300285
54	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.22996956
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.22573845
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.22573845
57	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21346591
58	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.18277068
59	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16917116
60	TAF2_19829295_ChIP-Seq_ESCs_Human	1.16869675
61	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15180241
62	MYC_18940864_ChIP-ChIP_HL60_Human	1.14866584
63	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13832173
64	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.13414584
65	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.12686843
66	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12591291
67	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.10878629
68	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10347288
69	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.08559176
70	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07749088
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07718977
72	RUNX_20019798_ChIP-Seq_JUKART_Human	1.07212765
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07024838
74	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.06973322
75	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06423405
76	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.04571951
77	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.04231814
78	RBPJ_21746931_ChIP-Seq_IB4_Human	1.04040309
79	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.03870321
80	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02802372
81	BCAT_22108803_ChIP-Seq_LS180_Human	1.02557832
82	AR_20517297_ChIP-Seq_VCAP_Human	1.01598801
83	ETV1_20927104_ChIP-Seq_GIST48_Human	1.00572436
84	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00417513
85	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00179390
86	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00110025
87	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.99704408
88	GATA3_27048872_Chip-Seq_THYMUS_Human	0.99692371
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.98918449
90	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.98047350
91	TAF15_26573619_Chip-Seq_HEK293_Human	0.97587412
92	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.96495429
93	MYC_19829295_ChIP-Seq_ESCs_Human	0.96435203
94	TCF4_22108803_ChIP-Seq_LS180_Human	0.96398936
95	FUS_26573619_Chip-Seq_HEK293_Human	0.95635026
96	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	0.95007448
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94745614
98	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.94277862
99	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.93993861
100	PHF8_20622853_ChIP-Seq_HELA_Human	0.92906052

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	4.22880912
2	MP0009379_abnormal_foot_pigmentation	3.69254859
3	MP0005671_abnormal_response_to	3.60457660
4	MP0003646_muscle_fatigue	3.17592926
5	MP0006292_abnormal_olfactory_placode	2.79962162
6	MP0001348_abnormal_lacrimal_gland	2.60227018
7	MP0004145_abnormal_muscle_electrophysio	2.55777020
8	MP0006072_abnormal_retinal_apoptosis	2.53797897
9	MP0001986_abnormal_taste_sensitivity	2.24094889
10	MP0004142_abnormal_muscle_tone	2.15943487
11	MP0002163_abnormal_gland_morphology	2.14148213
12	MP0009333_abnormal_splenocyte_physiolog	2.12288627
13	MP0008872_abnormal_physiological_respon	2.03334011
14	MP0002837_dystrophic_cardiac_calcinosis	2.00701621
15	MP0001968_abnormal_touch/_nociception	1.98397898
16	MP0003880_abnormal_central_pattern	1.96252326
17	MP0001984_abnormal_olfaction	1.92601625
18	MP0001873_stomach_inflammation	1.92155875
19	MP0003806_abnormal_nucleotide_metabolis	1.89160960
20	MP0005387_immune_system_phenotype	1.83523699
21	MP0001790_abnormal_immune_system	1.83523699
22	MP0005423_abnormal_somatic_nervous	1.78570073
23	MP0003195_calcinosis	1.77306057
24	MP0005408_hypopigmentation	1.70132084
25	MP0002736_abnormal_nociception_after	1.69922868
26	MP0002138_abnormal_hepatobiliary_system	1.67319680
27	MP0001800_abnormal_humoral_immune	1.67271544
28	MP0008875_abnormal_xenobiotic_pharmacok	1.66992786
29	MP0008877_abnormal_DNA_methylation	1.64951010
30	MP0002277_abnormal_respiratory_mucosa	1.64806418
31	MP0002166_altered_tumor_susceptibility	1.59580477
32	MP0005379_endocrine/exocrine_gland_phen	1.57818303
33	MP0005075_abnormal_melanosome_morpholog	1.55778812
34	MP0002723_abnormal_immune_serum	1.47610821
35	MP0005253_abnormal_eye_physiology	1.46598139
36	MP0005645_abnormal_hypothalamus_physiol	1.45791413
37	MP0009785_altered_susceptibility_to	1.44670378
38	MP0005551_abnormal_eye_electrophysiolog	1.41697116
39	MP0002148_abnormal_hypersensitivity_rea	1.38972394
40	MP0001819_abnormal_immune_cell	1.37349023
41	MP0001970_abnormal_pain_threshold	1.36905469
42	MP0002272_abnormal_nervous_system	1.36389527
43	MP0002733_abnormal_thermal_nociception	1.35709140
44	MP0000372_irregular_coat_pigmentation	1.34945423
45	MP0002006_tumorigenesis	1.32907911
46	MP0005000_abnormal_immune_tolerance	1.32282364
47	MP0002452_abnormal_antigen_presenting	1.30665844
48	MP0002420_abnormal_adaptive_immunity	1.30463633
49	MP0004742_abnormal_vestibular_system	1.28756699
50	MP0009745_abnormal_behavioral_response	1.27655524
51	MP0003763_abnormal_thymus_physiology	1.23982951
52	MP0002638_abnormal_pupillary_reflex	1.20958063
53	MP0001905_abnormal_dopamine_level	1.19646707
54	MP0002102_abnormal_ear_morphology	1.18584584
55	MP0000685_abnormal_immune_system	1.17610314
56	MP0004885_abnormal_endolymph	1.17507040
57	MP0008995_early_reproductive_senescence	1.15609271
58	MP0003786_premature_aging	1.11666039
59	MP0005084_abnormal_gallbladder_morpholo	1.09748028
60	MP0006276_abnormal_autonomic_nervous	1.06908814
61	MP0005025_abnormal_response_to	1.05835427
62	MP0009764_decreased_sensitivity_to	1.05068090
63	MP0001440_abnormal_grooming_behavior	1.00433702
64	MP0005646_abnormal_pituitary_gland	0.97828136
65	MP0004019_abnormal_vitamin_homeostasis	0.94887814
66	MP0002933_joint_inflammation	0.94088992
67	MP0002653_abnormal_ependyma_morphology	0.93729664
68	MP0002735_abnormal_chemical_nociception	0.92175801
69	MP0003878_abnormal_ear_physiology	0.89777993
70	MP0005377_hearing/vestibular/ear_phenot	0.89777993
71	MP0001501_abnormal_sleep_pattern	0.89574961
72	MP0000716_abnormal_immune_system	0.88290850
73	MP0003866_abnormal_defecation	0.88187583
74	MP0001188_hyperpigmentation	0.86713832
75	MP0000631_abnormal_neuroendocrine_gland	0.85909548
76	MP0006082_CNS_inflammation	0.84976854
77	MP0003136_yellow_coat_color	0.84067614
78	MP0002184_abnormal_innervation	0.82670108
79	MP0002876_abnormal_thyroid_physiology	0.82115655
80	MP0000538_abnormal_urinary_bladder	0.78454854
81	MP0003186_abnormal_redox_activity	0.77513717
82	MP0003119_abnormal_digestive_system	0.76621576
83	MP0001663_abnormal_digestive_system	0.76255704
84	MP0002557_abnormal_social/conspecific_i	0.74405061
85	MP0009046_muscle_twitch	0.73262413
86	MP0002693_abnormal_pancreas_physiology	0.71697933
87	MP0004043_abnormal_pH_regulation	0.71279044
88	MP0002572_abnormal_emotion/affect_behav	0.70562269
89	MP0001919_abnormal_reproductive_system	0.70392845
90	MP0001845_abnormal_inflammatory_respons	0.70003669
91	MP0001661_extended_life_span	0.69184190
92	MP0001293_anophthalmia	0.68612460
93	MP0010155_abnormal_intestine_physiology	0.68508006
94	MP0001756_abnormal_urination	0.68391640
95	MP0002398_abnormal_bone_marrow	0.68368834
96	MP0001853_heart_inflammation	0.67375110
97	MP0005083_abnormal_biliary_tract	0.66291577
98	MP0005410_abnormal_fertilization	0.65748232
99	MP0001486_abnormal_startle_reflex	0.65702261
100	MP0002734_abnormal_mechanical_nocicepti	0.65629309

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.74945317
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.44449104
3	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.38605499
4	Mitochondrial inheritance (HP:0001427)	4.31653489
5	Elevated erythrocyte sedimentation rate (HP:0003565)	4.17467740
6	Acute encephalopathy (HP:0006846)	3.97773856
7	Progressive macrocephaly (HP:0004481)	3.93903994
8	Increased CSF lactate (HP:0002490)	3.85654760
9	Abnormal rod and cone electroretinograms (HP:0008323)	3.81605385
10	Congenital stationary night blindness (HP:0007642)	3.80876569
11	Increased IgM level (HP:0003496)	3.76620951
12	Increased hepatocellular lipid droplets (HP:0006565)	3.74284244
13	3-Methylglutaconic aciduria (HP:0003535)	3.71127382
14	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.47992019
15	Absent/shortened dynein arms (HP:0200106)	3.47992019
16	Increased intramyocellular lipid droplets (HP:0012240)	3.44787114
17	Hepatocellular necrosis (HP:0001404)	3.42666426
18	Hypoproteinemia (HP:0003075)	3.42333963
19	Lipid accumulation in hepatocytes (HP:0006561)	3.31954651
20	IgG deficiency (HP:0004315)	3.28895647
21	Renal Fanconi syndrome (HP:0001994)	3.17805254
22	Optic disc pallor (HP:0000543)	3.10823237
23	Aplastic anemia (HP:0001915)	2.99789847
24	Hepatic necrosis (HP:0002605)	2.93629567
25	Cerebral edema (HP:0002181)	2.87199994
26	Increased muscle lipid content (HP:0009058)	2.77071167
27	Decreased central vision (HP:0007663)	2.75424748
28	Exertional dyspnea (HP:0002875)	2.70465634
29	Methylmalonic acidemia (HP:0002912)	2.68505473
30	Stomatitis (HP:0010280)	2.62442381
31	Pendular nystagmus (HP:0012043)	2.54698896
32	Abnormality of cells of the erythroid lineage (HP:0012130)	2.54654770
33	Autoimmune hemolytic anemia (HP:0001890)	2.54375274
34	Reticulocytopenia (HP:0001896)	2.53889141
35	Abolished electroretinogram (ERG) (HP:0000550)	2.53130805
36	Hemoptysis (HP:0002105)	2.49511713
37	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.48260011
38	Congenital, generalized hypertrichosis (HP:0004540)	2.48113899
39	Increased serum lactate (HP:0002151)	2.47116712
40	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.45860441
41	Attenuation of retinal blood vessels (HP:0007843)	2.44090554
42	Cerebral palsy (HP:0100021)	2.43809418
43	Pancreatic cysts (HP:0001737)	2.42877525
44	Abnormality of midbrain morphology (HP:0002418)	2.35656735
45	Molar tooth sign on MRI (HP:0002419)	2.35656735
46	Abnormality of homocysteine metabolism (HP:0010919)	2.32234201
47	Homocystinuria (HP:0002156)	2.32234201
48	Abnormal respiratory epithelium morphology (HP:0012253)	2.31162850
49	Abnormal respiratory motile cilium morphology (HP:0005938)	2.31162850
50	Colon cancer (HP:0003003)	2.30017696
51	Leukodystrophy (HP:0002415)	2.26385982
52	Stenosis of the external auditory canal (HP:0000402)	2.23447009
53	Eosinophilia (HP:0001880)	2.22840783
54	Constricted visual fields (HP:0001133)	2.22148505
55	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.20337652
56	Abnormality of alanine metabolism (HP:0010916)	2.20337652
57	Hyperalaninemia (HP:0003348)	2.20337652
58	Respiratory difficulties (HP:0002880)	2.17766539
59	Severe combined immunodeficiency (HP:0004430)	2.17311228
60	Macrocytic anemia (HP:0001972)	2.16796358
61	Abnormal ciliary motility (HP:0012262)	2.15733287
62	Lactic acidosis (HP:0003128)	2.15165937
63	Abnormality of B cell number (HP:0010975)	2.15142668
64	Respiratory failure (HP:0002878)	2.14686904
65	Hypoplasia of the ulna (HP:0003022)	2.14251262
66	Abnormal respiratory motile cilium physiology (HP:0012261)	2.13223336
67	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.11341472
68	Methylmalonic aciduria (HP:0012120)	2.11158923
69	Lethargy (HP:0001254)	2.09046596
70	Exercise intolerance (HP:0003546)	2.06625134
71	Adrenal hypoplasia (HP:0000835)	2.04778016
72	Abnormal number of erythroid precursors (HP:0012131)	2.01159621
73	Abnormality of eosinophils (HP:0001879)	2.01113058
74	Chronic mucocutaneous candidiasis (HP:0002728)	1.99506139
75	Recurrent cutaneous fungal infections (HP:0011370)	1.99506139
76	Forearm undergrowth (HP:0009821)	1.98358861
77	Pancreatic fibrosis (HP:0100732)	1.97085655
78	B lymphocytopenia (HP:0010976)	1.96255110
79	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.95015403
80	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.95015403
81	Abnormality of renal resorption (HP:0011038)	1.94740061
82	Pancytopenia (HP:0001876)	1.94191925
83	Hypoplasia of the radius (HP:0002984)	1.93626569
84	Abnormality of the prostate (HP:0008775)	1.90671029
85	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.88847343
86	Thyroiditis (HP:0100646)	1.88405948
87	Abnormality of T cell number (HP:0011839)	1.87305648
88	Obstructive lung disease (HP:0006536)	1.87093466
89	Chronic obstructive pulmonary disease (HP:0006510)	1.87093466
90	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.84643123
91	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.84366354
92	Parakeratosis (HP:0001036)	1.84182613
93	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.83119827
94	Nephronophthisis (HP:0000090)	1.81927449
95	Abnormality of DNA repair (HP:0003254)	1.80804380
96	Abnormality of urine glucose concentration (HP:0011016)	1.77464120
97	Glycosuria (HP:0003076)	1.77464120
98	Radial bowing (HP:0002986)	1.77046574
99	Abnormality of the renal cortex (HP:0011035)	1.75758276
100	Hyperphosphaturia (HP:0003109)	1.75198111

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.71057674
2	TXK	3.63511181
3	MAP3K12	3.40500314
4	ADRBK2	3.28631429
5	KDR	3.27546391
6	PDK2	3.09833230
7	MAP4K1	2.99226168
8	BCKDK	2.92273404
9	TLK1	2.76773441
10	VRK2	2.71952504
11	PINK1	2.05649659
12	GRK1	2.02776451
13	MYLK	1.97282037
14	ITK	1.77217623
15	STK38L	1.71629521
16	VRK1	1.66988025
17	PIK3CA	1.58693803
18	MAP4K2	1.58071166
19	WNK4	1.46589125
20	INSRR	1.40487122
21	TEC	1.38507876
22	BUB1	1.35802049
23	TIE1	1.33939028
24	DYRK2	1.33431737
25	IKBKB	1.31590723
26	CDK19	1.23937058
27	NUAK1	1.23521071
28	BTK	1.22552838
29	FES	1.18755198
30	CSF1R	1.17101633
31	NEK1	1.12009356
32	ZAK	1.10754945
33	STK24	1.09228826
34	EIF2AK3	1.08322112
35	EIF2AK1	1.04837512
36	MAP3K11	1.04277213
37	EPHA4	1.02686087
38	PRKCQ	1.00816582
39	AKT3	0.98829033
40	BCR	0.95694919
41	ADRBK1	0.86876542
42	PAK3	0.84918458
43	SYK	0.83278239
44	WNK3	0.83193125
45	OXSR1	0.82971508
46	DAPK3	0.81815556
47	LCK	0.79522843
48	KIT	0.79293519
49	STK16	0.78683626
50	RPS6KA5	0.78632943
51	OBSCN	0.77462911
52	BMPR1B	0.77455209
53	LYN	0.76610428
54	CAMKK2	0.71578644
55	LRRK2	0.70142511
56	CAMK1	0.66673630
57	CSK	0.65638423
58	PRKD3	0.64484190
59	TAOK3	0.63356862
60	PRKACA	0.62942318
61	PRKCE	0.62787346
62	PHKG2	0.60721477
63	PHKG1	0.60721477
64	ROCK1	0.58850737
65	MARK3	0.56394380
66	TAF1	0.56249871
67	SCYL2	0.53709549
68	PIM1	0.52278782
69	ERBB2	0.50388709
70	PRKCA	0.49981252
71	CAMK2A	0.49681269
72	TSSK6	0.49104689
73	DAPK1	0.48046629
74	MST4	0.47792435
75	ILK	0.46911615
76	GRK7	0.45581926
77	NEK6	0.41641460
78	PRKACG	0.41513930
79	PRKCG	0.41245205
80	MAPK15	0.40485347
81	PRKCD	0.40078640
82	IGF1R	0.39396270
83	PTK2B	0.38931431
84	MAP2K6	0.37826900
85	SGK223	0.37226688
86	SGK494	0.37226688
87	EPHB2	0.35586012
88	MUSK	0.34138235
89	MAP2K7	0.33928738
90	TRIM28	0.33740268
91	PIK3CG	0.33591589
92	INSR	0.33313232
93	PKN1	0.33114935
94	TNIK	0.33103520
95	LIMK1	0.32639975
96	CSNK2A2	0.32550795
97	CSNK2A1	0.32432970
98	TESK2	0.32187013
99	PLK3	0.31495078
100	CSNK1A1	0.31322471

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.92918661
2	Allograft rejection_Homo sapiens_hsa05330	3.83962628
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.61241862
4	Ribosome_Homo sapiens_hsa03010	3.55571355
5	Graft-versus-host disease_Homo sapiens_hsa05332	3.49158565
6	Oxidative phosphorylation_Homo sapiens_hsa00190	3.47756984
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.20099950
8	Proteasome_Homo sapiens_hsa03050	3.11623499
9	Type I diabetes mellitus_Homo sapiens_hsa04940	3.04633651
10	Parkinsons disease_Homo sapiens_hsa05012	2.72904767
11	Protein export_Homo sapiens_hsa03060	2.48283065
12	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.38911278
13	Antigen processing and presentation_Homo sapiens_hsa04612	2.37566483
14	Primary immunodeficiency_Homo sapiens_hsa05340	2.23722197
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.94431096
16	Alzheimers disease_Homo sapiens_hsa05010	1.81079681
17	Huntingtons disease_Homo sapiens_hsa05016	1.74478992
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.74436923
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.58260262
20	Rheumatoid arthritis_Homo sapiens_hsa05323	1.55069785
21	Phototransduction_Homo sapiens_hsa04744	1.48755422
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.47671529
23	RNA polymerase_Homo sapiens_hsa03020	1.45243015
24	Caffeine metabolism_Homo sapiens_hsa00232	1.34353892
25	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.29653900
26	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.25333228
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.24754300
28	Viral myocarditis_Homo sapiens_hsa05416	1.21162171
29	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.17326991
30	Basal transcription factors_Homo sapiens_hsa03022	1.05268461
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.04608534
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.02866870
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.01015565
34	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.00326746
35	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.99895786
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.95256377
37	Butanoate metabolism_Homo sapiens_hsa00650	0.93785082
38	Olfactory transduction_Homo sapiens_hsa04740	0.90058838
39	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.88888390
40	Homologous recombination_Homo sapiens_hsa03440	0.85694275
41	RNA degradation_Homo sapiens_hsa03018	0.83326699
42	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.83068187
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.79127285
44	Nicotine addiction_Homo sapiens_hsa05033	0.77996149
45	Propanoate metabolism_Homo sapiens_hsa00640	0.77397426
46	Leishmaniasis_Homo sapiens_hsa05140	0.77109686
47	Regulation of autophagy_Homo sapiens_hsa04140	0.72409131
48	Collecting duct acid secretion_Homo sapiens_hsa04966	0.72058432
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71772865
50	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.70819253
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.69888068
52	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.66333580
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.65437881
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.64311185
55	Peroxisome_Homo sapiens_hsa04146	0.63472598
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62928951
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.62520270
58	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.62286045
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61906113
60	Nucleotide excision repair_Homo sapiens_hsa03420	0.61607972
61	Non-homologous end-joining_Homo sapiens_hsa03450	0.61135200
62	One carbon pool by folate_Homo sapiens_hsa00670	0.60433784
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60249751
64	Selenocompound metabolism_Homo sapiens_hsa00450	0.59920993
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.58734329
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.58450540
67	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55937634
68	Purine metabolism_Homo sapiens_hsa00230	0.53434095
69	Retinol metabolism_Homo sapiens_hsa00830	0.52564574
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51486327
71	Taste transduction_Homo sapiens_hsa04742	0.45702819
72	Fanconi anemia pathway_Homo sapiens_hsa03460	0.45653093
73	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.41266584
74	Measles_Homo sapiens_hsa05162	0.40799410
75	Phagosome_Homo sapiens_hsa04145	0.38962729
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37328449
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36433241
78	ABC transporters_Homo sapiens_hsa02010	0.35438020
79	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.35149472
80	Metabolic pathways_Homo sapiens_hsa01100	0.33816092
81	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.32496543
82	Mineral absorption_Homo sapiens_hsa04978	0.31888931
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.29402992
84	African trypanosomiasis_Homo sapiens_hsa05143	0.29194708
85	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.27458644
86	Salmonella infection_Homo sapiens_hsa05132	0.27417778
87	Sulfur metabolism_Homo sapiens_hsa00920	0.25388354
88	GABAergic synapse_Homo sapiens_hsa04727	0.24899764
89	Spliceosome_Homo sapiens_hsa03040	0.23981285
90	Ether lipid metabolism_Homo sapiens_hsa00565	0.23257914
91	RNA transport_Homo sapiens_hsa03013	0.22055358
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.19327564
93	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.19181806
94	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.19015819
95	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.18832515
96	Malaria_Homo sapiens_hsa05144	0.16684243
97	Herpes simplex infection_Homo sapiens_hsa05168	0.16366843
98	Morphine addiction_Homo sapiens_hsa05032	0.15042040
99	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.14699487
100	Legionellosis_Homo sapiens_hsa05134	0.13557465

RPL21P103

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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