ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	6.95005790
2	translational termination (GO:0006415)	6.72370475
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.34080785
4	ATP synthesis coupled proton transport (GO:0015986)	6.34080785
5	ribosomal small subunit assembly (GO:0000028)	6.12019522
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.11330229
7	cotranslational protein targeting to membrane (GO:0006613)	6.06136501
8	protein targeting to ER (GO:0045047)	5.98600688
9	ribosomal small subunit biogenesis (GO:0042274)	5.93762017
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.86754249
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.75804398
12	protein localization to endoplasmic reticulum (GO:0070972)	5.71436353
13	translational elongation (GO:0006414)	5.66203181
14	maturation of SSU-rRNA (GO:0030490)	5.56679478
15	protein neddylation (GO:0045116)	5.52517328
16	viral life cycle (GO:0019058)	4.98916534
17	cellular protein complex disassembly (GO:0043624)	4.97901274
18	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.89259458
19	NADH dehydrogenase complex assembly (GO:0010257)	4.77549168
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.77549168
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.77549168
22	protein localization to cilium (GO:0061512)	4.62755791
23	ribosomal large subunit biogenesis (GO:0042273)	4.52292521
24	translational initiation (GO:0006413)	4.34500187
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.26527339
26	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.26249170
27	termination of RNA polymerase III transcription (GO:0006386)	4.26249170
28	protein complex biogenesis (GO:0070271)	4.24148235
29	nonmotile primary cilium assembly (GO:0035058)	4.18720894
30	protein complex disassembly (GO:0043241)	4.07750555
31	protein targeting to membrane (GO:0006612)	4.05969175
32	respiratory electron transport chain (GO:0022904)	4.02699088
33	behavioral response to nicotine (GO:0035095)	4.02214794
34	electron transport chain (GO:0022900)	3.99833303
35	translation (GO:0006412)	3.98290306
36	macromolecular complex disassembly (GO:0032984)	3.92839289
37	platelet dense granule organization (GO:0060155)	3.92546353
38	mitochondrial respiratory chain complex assembly (GO:0033108)	3.88112106
39	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.81030029
40	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.79355774
41	negative regulation of appetite (GO:0032099)	3.74248819
42	negative regulation of response to food (GO:0032096)	3.74248819
43	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.66825122
44	GTP biosynthetic process (GO:0006183)	3.57859801
45	aldehyde catabolic process (GO:0046185)	3.53460346
46	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.47930337
47	mRNA catabolic process (GO:0006402)	3.45072723
48	ATP biosynthetic process (GO:0006754)	3.44794717
49	fucose catabolic process (GO:0019317)	3.44235695
50	L-fucose metabolic process (GO:0042354)	3.44235695
51	L-fucose catabolic process (GO:0042355)	3.44235695
52	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.43131893
53	regulation of cilium movement (GO:0003352)	3.36612345
54	hydrogen ion transmembrane transport (GO:1902600)	3.35797027
55	proton transport (GO:0015992)	3.26962902
56	chaperone-mediated protein transport (GO:0072321)	3.25911448
57	cellular component biogenesis (GO:0044085)	3.24728813
58	hydrogen transport (GO:0006818)	3.21257735
59	ribonucleoprotein complex biogenesis (GO:0022613)	3.21219535
60	negative regulation of mast cell activation (GO:0033004)	3.16921291
61	RNA catabolic process (GO:0006401)	3.14844906
62	regulation of immunoglobulin secretion (GO:0051023)	3.02136947
63	proteasome assembly (GO:0043248)	3.01997457
64	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.00780321
65	kynurenine metabolic process (GO:0070189)	2.98757728
66	UTP biosynthetic process (GO:0006228)	2.98732608
67	rRNA catabolic process (GO:0016075)	2.97822007
68	detection of light stimulus involved in sensory perception (GO:0050962)	2.93655352
69	detection of light stimulus involved in visual perception (GO:0050908)	2.93655352
70	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.90572316
71	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.90572316
72	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.87424364
73	endoderm formation (GO:0001706)	2.87410904
74	establishment of protein localization to membrane (GO:0090150)	2.83633798
75	indole-containing compound catabolic process (GO:0042436)	2.78677289
76	indolalkylamine catabolic process (GO:0046218)	2.78677289
77	tryptophan catabolic process (GO:0006569)	2.78677289
78	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.77046671
79	regulation of microtubule-based movement (GO:0060632)	2.74392702
80	UTP metabolic process (GO:0046051)	2.66167919
81	viral protein processing (GO:0019082)	2.64876008
82	protein targeting (GO:0006605)	2.61862512
83	axoneme assembly (GO:0035082)	2.60474610
84	water-soluble vitamin biosynthetic process (GO:0042364)	2.56758189
85	substrate-independent telencephalic tangential migration (GO:0021826)	2.55106458
86	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.55106458
87	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.54418919
88	tongue development (GO:0043586)	2.54414615
89	short-term memory (GO:0007614)	2.52778075
90	rRNA metabolic process (GO:0016072)	2.51880663
91	appendage development (GO:0048736)	2.51150562
92	limb development (GO:0060173)	2.51150562
93	interferon-gamma production (GO:0032609)	2.50625626
94	negative regulation of heart rate (GO:0010459)	2.47760853
95	rRNA processing (GO:0006364)	2.47621514
96	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.46033783
97	auditory receptor cell differentiation (GO:0042491)	2.44127230
98	regulation of cellular respiration (GO:0043457)	2.43408826
99	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.43268282
100	melanosome transport (GO:0032402)	2.41140880

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.33826991
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.33212876
3	VDR_22108803_ChIP-Seq_LS180_Human	3.68084179
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.41508159
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.76845038
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.73460669
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.61238548
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.49943885
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.36746563
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.20008649
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.06080913
12	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.04855273
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.04105896
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.90773977
15	VDR_23849224_ChIP-Seq_CD4+_Human	1.86727048
16	IRF1_19129219_ChIP-ChIP_H3396_Human	1.85956454
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.85683103
18	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.78913216
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.78779766
20	TP53_22573176_ChIP-Seq_HFKS_Human	1.73339044
21	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.72722729
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71296956
23	EWS_26573619_Chip-Seq_HEK293_Human	1.70614380
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.65560691
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.65011848
26	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.62072752
27	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.57480607
28	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.57480607
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.56894248
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.54360726
31	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.45795486
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.44518063
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44225750
34	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.43292589
35	TTF2_22483619_ChIP-Seq_HELA_Human	1.42147744
36	P300_19829295_ChIP-Seq_ESCs_Human	1.42032032
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41995386
38	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.37741824
39	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.37314336
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.35840717
41	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.34697841
42	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.31898608
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30386472
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30386472
45	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.30061373
46	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26747212
47	ER_23166858_ChIP-Seq_MCF-7_Human	1.24655771
48	NCOR_22424771_ChIP-Seq_293T_Human	1.23469051
49	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.21990227
50	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.20733879
51	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.19613359
52	MYC_19829295_ChIP-Seq_ESCs_Human	1.18727407
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.18554695
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18554695
55	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.17296594
56	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.15778425
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15380992
58	IGF1R_20145208_ChIP-Seq_DFB_Human	1.13383169
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12882659
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12494838
61	FUS_26573619_Chip-Seq_HEK293_Human	1.11297336
62	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.10796201
63	NANOG_20526341_ChIP-Seq_ESCs_Human	1.09682303
64	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09357889
65	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08808764
66	REST_21632747_ChIP-Seq_MESCs_Mouse	1.08778826
67	AR_20517297_ChIP-Seq_VCAP_Human	1.07714584
68	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.07672300
69	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.07047467
70	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.06397583
71	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.06323177
72	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.03249044
73	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03143828
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.02873370
75	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.99897076
76	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.98561514
77	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.97386988
78	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.96884672
79	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.94899696
80	RNF2_27304074_Chip-Seq_NSC_Mouse	0.94608116
81	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.93667578
82	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.92487575
83	ERG_20517297_ChIP-Seq_VCAP_Human	0.92091326
84	TCF4_22108803_ChIP-Seq_LS180_Human	0.91285935
85	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.91077667
86	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.90617866
87	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.90428883
88	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.90428883
89	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.90327846
90	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.90045516
91	TAF15_26573619_Chip-Seq_HEK293_Human	0.89988154
92	SMRT_27268052_Chip-Seq_Bcells_Human	0.89485627
93	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.89324118
94	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.89306255
95	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.89189098
96	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.88774014
97	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.88570033
98	GATA3_26560356_Chip-Seq_TH2_Human	0.88174136
99	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.87414285
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.87244788

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.30774876
2	MP0004142_abnormal_muscle_tone	3.25124141
3	MP0001835_abnormal_antigen_presentation	3.19526347
4	MP0009379_abnormal_foot_pigmentation	3.18554678
5	MP0003787_abnormal_imprinting	3.05520567
6	MP0001529_abnormal_vocalization	3.03268783
7	MP0008877_abnormal_DNA_methylation	2.76408326
8	MP0008789_abnormal_olfactory_epithelium	2.70435539
9	MP0004145_abnormal_muscle_electrophysio	2.38298672
10	MP0001984_abnormal_olfaction	2.24381506
11	MP0003806_abnormal_nucleotide_metabolis	2.23007365
12	MP0005394_taste/olfaction_phenotype	2.18960993
13	MP0005499_abnormal_olfactory_system	2.18960993
14	MP0002163_abnormal_gland_morphology	2.15786124
15	MP0002102_abnormal_ear_morphology	2.05886595
16	MP0003122_maternal_imprinting	2.02531006
17	MP0001348_abnormal_lacrimal_gland	1.97818434
18	MP0001968_abnormal_touch/_nociception	1.96293204
19	MP0001485_abnormal_pinna_reflex	1.92104894
20	MP0005645_abnormal_hypothalamus_physiol	1.76220513
21	MP0003880_abnormal_central_pattern	1.75375878
22	MP0001440_abnormal_grooming_behavior	1.72683777
23	MP0002837_dystrophic_cardiac_calcinosis	1.72417911
24	MP0005551_abnormal_eye_electrophysiolog	1.71411139
25	MP0008872_abnormal_physiological_respon	1.67129438
26	MP0002272_abnormal_nervous_system	1.66767592
27	MP0002736_abnormal_nociception_after	1.65383930
28	MP0005379_endocrine/exocrine_gland_phen	1.62556943
29	MP0005075_abnormal_melanosome_morpholog	1.60106251
30	MP0002734_abnormal_mechanical_nocicepti	1.59559719
31	MP0001486_abnormal_startle_reflex	1.57781749
32	MP0006072_abnormal_retinal_apoptosis	1.57237990
33	MP0001986_abnormal_taste_sensitivity	1.56017933
34	MP0003121_genomic_imprinting	1.51023905
35	MP0004742_abnormal_vestibular_system	1.50693244
36	MP0001905_abnormal_dopamine_level	1.50256838
37	MP0009745_abnormal_behavioral_response	1.49249121
38	MP0005377_hearing/vestibular/ear_phenot	1.43633160
39	MP0003878_abnormal_ear_physiology	1.43633160
40	MP0005671_abnormal_response_to	1.40271422
41	MP0001970_abnormal_pain_threshold	1.38093103
42	MP0001293_anophthalmia	1.32524143
43	MP0000049_abnormal_middle_ear	1.32124315
44	MP0003567_abnormal_fetal_cardiomyocyte	1.31250989
45	MP0002653_abnormal_ependyma_morphology	1.29454106
46	MP0000372_irregular_coat_pigmentation	1.28117292
47	MP0003195_calcinosis	1.25931250
48	MP0006276_abnormal_autonomic_nervous	1.25593766
49	MP0004885_abnormal_endolymph	1.22406244
50	MP0009046_muscle_twitch	1.21297535
51	MP0002572_abnormal_emotion/affect_behav	1.20932454
52	MP0003646_muscle_fatigue	1.16962993
53	MP0003123_paternal_imprinting	1.16625219
54	MP0008875_abnormal_xenobiotic_pharmacok	1.15700419
55	MP0005253_abnormal_eye_physiology	1.14878740
56	MP0005389_reproductive_system_phenotype	1.10327925
57	MP0002557_abnormal_social/conspecific_i	1.09951651
58	MP0002160_abnormal_reproductive_system	1.09636727
59	MP0000427_abnormal_hair_cycle	1.08590686
60	MP0005387_immune_system_phenotype	1.04314722
61	MP0001790_abnormal_immune_system	1.04314722
62	MP0003186_abnormal_redox_activity	1.02939089
63	MP0005195_abnormal_posterior_eye	1.00677333
64	MP0006036_abnormal_mitochondrial_physio	1.00622601
65	MP0004381_abnormal_hair_follicle	1.00124424
66	MP0000026_abnormal_inner_ear	0.96909447
67	MP0002067_abnormal_sensory_capabilities	0.96677366
68	MP0002184_abnormal_innervation	0.95536735
69	MP0000631_abnormal_neuroendocrine_gland	0.93834958
70	MP0003890_abnormal_embryonic-extraembry	0.93567977
71	MP0005408_hypopigmentation	0.92222700
72	MP0002752_abnormal_somatic_nervous	0.91260973
73	MP0001800_abnormal_humoral_immune	0.90704298
74	MP0004133_heterotaxia	0.90452999
75	MP0002938_white_spotting	0.89844250
76	MP0002064_seizures	0.88953234
77	MP0002876_abnormal_thyroid_physiology	0.88434213
78	MP0000955_abnormal_spinal_cord	0.87472596
79	MP0003635_abnormal_synaptic_transmissio	0.87432420
80	MP0005423_abnormal_somatic_nervous	0.84864650
81	MP0002638_abnormal_pupillary_reflex	0.83989570
82	MP0002733_abnormal_thermal_nociception	0.82462624
83	MP0001963_abnormal_hearing_physiology	0.82402558
84	MP0001502_abnormal_circadian_rhythm	0.82399369
85	MP0002138_abnormal_hepatobiliary_system	0.79314379
86	MP0004147_increased_porphyrin_level	0.77786902
87	MP0002095_abnormal_skin_pigmentation	0.77255586
88	MP0002234_abnormal_pharynx_morphology	0.76824776
89	MP0002735_abnormal_chemical_nociception	0.75907174
90	MP0001919_abnormal_reproductive_system	0.74638575
91	MP0004019_abnormal_vitamin_homeostasis	0.74006016
92	MP0009053_abnormal_anal_canal	0.72575891
93	MP0009764_decreased_sensitivity_to	0.71708776
94	MP0002063_abnormal_learning/memory/cond	0.70989854
95	MP0002751_abnormal_autonomic_nervous	0.69721581
96	MP0005636_abnormal_mineral_homeostasis	0.67811818
97	MP0005646_abnormal_pituitary_gland	0.66862061
98	MP0003718_maternal_effect	0.66606417
99	MP0000778_abnormal_nervous_system	0.65687892
100	MP0002229_neurodegeneration	0.65146148

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.88331507
2	Reticulocytopenia (HP:0001896)	4.72697162
3	Abnormality of midbrain morphology (HP:0002418)	4.27860959
4	Molar tooth sign on MRI (HP:0002419)	4.27860959
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.19658241
6	Acute encephalopathy (HP:0006846)	4.16435945
7	Progressive macrocephaly (HP:0004481)	4.02202396
8	Mitochondrial inheritance (HP:0001427)	3.96355206
9	Hepatocellular necrosis (HP:0001404)	3.95172592
10	Abnormality of cells of the erythroid lineage (HP:0012130)	3.59725195
11	Type II lissencephaly (HP:0007260)	3.50367964
12	Macrocytic anemia (HP:0001972)	3.48913449
13	Increased CSF lactate (HP:0002490)	3.42400441
14	Cerebellar dysplasia (HP:0007033)	3.39160007
15	Hepatic necrosis (HP:0002605)	3.22675750
16	Methylmalonic acidemia (HP:0002912)	3.17157220
17	Congenital, generalized hypertrichosis (HP:0004540)	3.13076089
18	Multiple enchondromatosis (HP:0005701)	3.08710304
19	Pancreatic cysts (HP:0001737)	3.04905846
20	Medial flaring of the eyebrow (HP:0010747)	3.03458836
21	Septo-optic dysplasia (HP:0100842)	2.95865247
22	Increased hepatocellular lipid droplets (HP:0006565)	2.91721495
23	Stomatitis (HP:0010280)	2.90891251
24	Pancreatic fibrosis (HP:0100732)	2.86974134
25	Lipid accumulation in hepatocytes (HP:0006561)	2.82994051
26	Cerebral edema (HP:0002181)	2.80787731
27	Increased IgM level (HP:0003496)	2.80110445
28	Optic disc pallor (HP:0000543)	2.73836621
29	IgG deficiency (HP:0004315)	2.71978649
30	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.71284534
31	Stenosis of the external auditory canal (HP:0000402)	2.71225905
32	Nephronophthisis (HP:0000090)	2.67792342
33	Pallor (HP:0000980)	2.66930864
34	Sclerocornea (HP:0000647)	2.62423967
35	Methylmalonic aciduria (HP:0012120)	2.62372807
36	Abnormal rod and cone electroretinograms (HP:0008323)	2.61514112
37	Leukodystrophy (HP:0002415)	2.59671952
38	Median cleft lip (HP:0000161)	2.57674425
39	Congenital stationary night blindness (HP:0007642)	2.55343595
40	Abnormal number of erythroid precursors (HP:0012131)	2.51330316
41	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.48567527
42	Elevated erythrocyte sedimentation rate (HP:0003565)	2.45875700
43	Cleft eyelid (HP:0000625)	2.44939023
44	3-Methylglutaconic aciduria (HP:0003535)	2.44377918
45	Homocystinuria (HP:0002156)	2.43667321
46	Abnormality of homocysteine metabolism (HP:0010919)	2.43667321
47	Gait imbalance (HP:0002141)	2.36343114
48	Adrenal hypoplasia (HP:0000835)	2.34912704
49	Hypomagnesemia (HP:0002917)	2.31932227
50	Exertional dyspnea (HP:0002875)	2.31272093
51	Congenital primary aphakia (HP:0007707)	2.26727524
52	Abolished electroretinogram (ERG) (HP:0000550)	2.23063950
53	Polyphagia (HP:0002591)	2.22822370
54	Abnormality of the renal medulla (HP:0100957)	2.22568538
55	Rib fusion (HP:0000902)	2.18409471
56	True hermaphroditism (HP:0010459)	2.18405047
57	Agitation (HP:0000713)	2.16759042
58	Porencephaly (HP:0002132)	2.16578056
59	Pendular nystagmus (HP:0012043)	2.11423267
60	Respiratory failure (HP:0002878)	2.10515573
61	Cystic liver disease (HP:0006706)	2.06204866
62	Cerebral palsy (HP:0100021)	2.06185732
63	Increased serum lactate (HP:0002151)	2.06055209
64	Renal Fanconi syndrome (HP:0001994)	2.04711998
65	Increased intramyocellular lipid droplets (HP:0012240)	2.03775481
66	Growth hormone deficiency (HP:0000824)	2.03202231
67	Abnormality of the labia minora (HP:0012880)	2.02489555
68	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.01356108
69	Bifid tongue (HP:0010297)	2.00819656
70	Aplasia/hypoplasia of the uterus (HP:0008684)	1.97721165
71	Bile duct proliferation (HP:0001408)	1.94017370
72	Abnormal biliary tract physiology (HP:0012439)	1.94017370
73	Myokymia (HP:0002411)	1.93846961
74	Nephrogenic diabetes insipidus (HP:0009806)	1.93473262
75	Abnormal hemoglobin (HP:0011902)	1.92805921
76	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.91920800
77	Optic nerve hypoplasia (HP:0000609)	1.91919791
78	Abnormality of magnesium homeostasis (HP:0004921)	1.91599761
79	Hypoplasia of the uterus (HP:0000013)	1.90975589
80	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.90020549
81	Aplastic anemia (HP:0001915)	1.87772399
82	Anterior segment dysgenesis (HP:0007700)	1.86172168
83	Severe muscular hypotonia (HP:0006829)	1.85966332
84	Lethargy (HP:0001254)	1.85787432
85	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.85157966
86	Hyperventilation (HP:0002883)	1.83612263
87	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.83333200
88	Hypoplasia of the ulna (HP:0003022)	1.83292534
89	Lactic acidosis (HP:0003128)	1.82269589
90	Abnormality of the renal cortex (HP:0011035)	1.81746105
91	Abnormality of vitamin B metabolism (HP:0004340)	1.81312958
92	Parakeratosis (HP:0001036)	1.81079103
93	Myotonia (HP:0002486)	1.80939944
94	Colon cancer (HP:0003003)	1.78430465
95	Absent septum pellucidum (HP:0001331)	1.77893802
96	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.76559133
97	Hypoplasia of the radius (HP:0002984)	1.76191429
98	Narrow forehead (HP:0000341)	1.76040152
99	Absent thumb (HP:0009777)	1.74936271
100	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.74915500

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.13552826
2	ADRBK2	2.73451254
3	CDK19	2.44317966
4	TXK	2.39740078
5	WNK3	2.23197898
6	GRK1	2.21209843
7	MAP4K1	2.13937365
8	NUAK1	2.10560481
9	MST4	2.07200654
10	PINK1	2.05694868
11	NME1	1.97959454
12	FRK	1.94966863
13	PIK3CA	1.94187292
14	ZAK	1.91233090
15	DYRK2	1.83247447
16	STK16	1.78663477
17	TNIK	1.61731331
18	MAP4K2	1.51541150
19	EIF2AK1	1.51526638
20	TEC	1.46808730
21	MAP3K4	1.43720065
22	LRRK2	1.41611779
23	TIE1	1.38717850
24	TRIM28	1.34313074
25	OXSR1	1.34111429
26	BCKDK	1.20618019
27	EPHB2	1.19694668
28	CSNK1G2	1.17949754
29	MAP3K13	1.17539166
30	EPHA4	1.15805487
31	PAK3	1.14880085
32	INSRR	1.14029114
33	EPHA3	1.12261731
34	PRKCG	1.09380809
35	CSNK1G1	1.05775981
36	IKBKB	1.05285596
37	NEK1	1.03694470
38	FES	1.01559067
39	CSNK1G3	0.98724580
40	AKT3	0.98639959
41	STK39	0.97627507
42	VRK2	0.94917997
43	PRKCE	0.93830498
44	ITK	0.92371364
45	KIT	0.91642670
46	MYLK	0.90087870
47	NLK	0.89498067
48	ADRBK1	0.87826238
49	TYRO3	0.84941109
50	CSNK1A1L	0.83287306
51	ICK	0.81230011
52	ILK	0.80557664
53	DAPK3	0.80276634
54	FLT3	0.75821095
55	SYK	0.75636234
56	CSNK2A2	0.75235558
57	RPS6KA5	0.72524414
58	PRKACA	0.72477208
59	OBSCN	0.71502779
60	MARK1	0.70698019
61	MAP3K12	0.69941368
62	GRK7	0.68941946
63	LYN	0.65087989
64	WNK1	0.64597188
65	BMPR1B	0.63971299
66	CSNK1E	0.63724307
67	NEK2	0.61235802
68	CAMK1	0.60945473
69	MAP2K7	0.60364875
70	SRPK1	0.59482580
71	PRKCQ	0.59119944
72	EIF2AK3	0.59029336
73	TYK2	0.58822849
74	CASK	0.58295063
75	PASK	0.56825749
76	SGK223	0.56743807
77	SGK494	0.56743807
78	SCYL2	0.56425389
79	NME2	0.55510866
80	EIF2AK2	0.54785303
81	PHKG1	0.54501914
82	PHKG2	0.54501914
83	PRKCZ	0.54454885
84	BTK	0.54219372
85	CSF1R	0.53277242
86	VRK1	0.52781410
87	DYRK1B	0.52584288
88	CSNK2A1	0.51169446
89	PRKCA	0.49826546
90	DAPK1	0.49594657
91	MINK1	0.48947148
92	NTRK2	0.48906499
93	RPS6KA6	0.48744254
94	PRKG1	0.48242894
95	CSNK1A1	0.46586744
96	CAMK2A	0.45863405
97	SGK1	0.45778451
98	CHUK	0.44307620
99	IKBKE	0.43806503
100	RPS6KA4	0.42415790

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.86970479
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.04289096
3	Asthma_Homo sapiens_hsa05310	3.92785802
4	Parkinsons disease_Homo sapiens_hsa05012	3.24751178
5	Allograft rejection_Homo sapiens_hsa05330	3.18168823
6	Protein export_Homo sapiens_hsa03060	3.06783563
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.03604209
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.90123802
9	RNA polymerase_Homo sapiens_hsa03020	2.62926463
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.57995961
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.41271714
12	Proteasome_Homo sapiens_hsa03050	2.40506263
13	Cardiac muscle contraction_Homo sapiens_hsa04260	2.32358007
14	Alzheimers disease_Homo sapiens_hsa05010	2.26816663
15	Huntingtons disease_Homo sapiens_hsa05016	2.24655062
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.87922170
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.70321462
18	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.58286706
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.56737946
20	RNA degradation_Homo sapiens_hsa03018	1.55952952
21	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.55125260
22	Nicotine addiction_Homo sapiens_hsa05033	1.46365450
23	Rheumatoid arthritis_Homo sapiens_hsa05323	1.33679113
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.32350673
25	Viral myocarditis_Homo sapiens_hsa05416	1.15923451
26	Regulation of autophagy_Homo sapiens_hsa04140	1.15874150
27	Phototransduction_Homo sapiens_hsa04744	1.13648143
28	Basal transcription factors_Homo sapiens_hsa03022	1.09826031
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.07103344
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.06688220
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.04923802
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.04614988
33	Antigen processing and presentation_Homo sapiens_hsa04612	1.02879506
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01795309
35	Homologous recombination_Homo sapiens_hsa03440	1.00895282
36	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.98328675
37	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.91183123
38	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89178511
39	Ether lipid metabolism_Homo sapiens_hsa00565	0.85232599
40	Pyrimidine metabolism_Homo sapiens_hsa00240	0.82763933
41	Nucleotide excision repair_Homo sapiens_hsa03420	0.81912252
42	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.80755586
43	Propanoate metabolism_Homo sapiens_hsa00640	0.78296936
44	Mismatch repair_Homo sapiens_hsa03430	0.76188102
45	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.75554522
46	Caffeine metabolism_Homo sapiens_hsa00232	0.75430552
47	One carbon pool by folate_Homo sapiens_hsa00670	0.74216232
48	Sulfur metabolism_Homo sapiens_hsa00920	0.73269079
49	Primary immunodeficiency_Homo sapiens_hsa05340	0.71448529
50	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.70172167
51	Folate biosynthesis_Homo sapiens_hsa00790	0.69631644
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.68141881
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.68095372
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67067923
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.65164601
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62317052
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.60062708
58	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.59238817
59	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.58571301
60	Nitrogen metabolism_Homo sapiens_hsa00910	0.57857753
61	Taste transduction_Homo sapiens_hsa04742	0.57345967
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.57227602
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57087908
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56460354
65	Purine metabolism_Homo sapiens_hsa00230	0.54635235
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51823765
67	Morphine addiction_Homo sapiens_hsa05032	0.51518074
68	Olfactory transduction_Homo sapiens_hsa04740	0.51224729
69	RNA transport_Homo sapiens_hsa03013	0.50848091
70	Metabolic pathways_Homo sapiens_hsa01100	0.48795036
71	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.47436497
72	Fanconi anemia pathway_Homo sapiens_hsa03460	0.43184513
73	GABAergic synapse_Homo sapiens_hsa04727	0.42642361
74	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.40655136
75	Spliceosome_Homo sapiens_hsa03040	0.38951231
76	Glutamatergic synapse_Homo sapiens_hsa04724	0.38110299
77	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.38102648
78	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.36624545
79	Sulfur relay system_Homo sapiens_hsa04122	0.36364004
80	Retinol metabolism_Homo sapiens_hsa00830	0.35509745
81	Butanoate metabolism_Homo sapiens_hsa00650	0.33701971
82	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33441843
83	Salivary secretion_Homo sapiens_hsa04970	0.33095186
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32179512
85	Phagosome_Homo sapiens_hsa04145	0.31158363
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.29926170
87	Fatty acid elongation_Homo sapiens_hsa00062	0.27830902
88	Serotonergic synapse_Homo sapiens_hsa04726	0.27259998
89	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.26186308
90	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.25577363
91	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.24741391
92	Leishmaniasis_Homo sapiens_hsa05140	0.24053789
93	Mineral absorption_Homo sapiens_hsa04978	0.21496161
94	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.20301904
95	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.19959631
96	Circadian entrainment_Homo sapiens_hsa04713	0.19408654
97	DNA replication_Homo sapiens_hsa03030	0.17759083
98	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.17735284
99	Peroxisome_Homo sapiens_hsa04146	0.17311864
100	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.15995938

RPL21P104

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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