ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.19755651
2	viral transcription (GO:0019083)	5.87726596
3	translational termination (GO:0006415)	5.64455199
4	ATP synthesis coupled proton transport (GO:0015986)	5.34657658
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.34657658
6	maturation of SSU-rRNA (GO:0030490)	5.23930809
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.06881610
8	cotranslational protein targeting to membrane (GO:0006613)	5.04195373
9	protein targeting to ER (GO:0045047)	5.00654942
10	chaperone-mediated protein transport (GO:0072321)	4.88960321
11	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.85536270
12	ribosomal small subunit biogenesis (GO:0042274)	4.82600151
13	translational elongation (GO:0006414)	4.79313982
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.77793418
15	protein localization to endoplasmic reticulum (GO:0070972)	4.77536192
16	protein complex biogenesis (GO:0070271)	4.70012972
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.67674855
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.67674855
19	NADH dehydrogenase complex assembly (GO:0010257)	4.67674855
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.65596569
21	DNA deamination (GO:0045006)	4.51052281
22	behavioral response to nicotine (GO:0035095)	4.50639469
23	protein neddylation (GO:0045116)	4.48329916
24	viral life cycle (GO:0019058)	4.25952120
25	mitochondrial respiratory chain complex assembly (GO:0033108)	4.23215019
26	cellular protein complex disassembly (GO:0043624)	4.16977398
27	ribosomal large subunit biogenesis (GO:0042273)	4.16050105
28	respiratory electron transport chain (GO:0022904)	4.12169494
29	electron transport chain (GO:0022900)	4.11594317
30	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.98916381
31	translational initiation (GO:0006413)	3.84542684
32	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.82965175
33	hydrogen ion transmembrane transport (GO:1902600)	3.79497332
34	water-soluble vitamin biosynthetic process (GO:0042364)	3.78346771
35	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.73090667
36	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.73090667
37	translation (GO:0006412)	3.64191294
38	respiratory chain complex IV assembly (GO:0008535)	3.55711896
39	proton transport (GO:0015992)	3.52866361
40	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.51642958
41	protein targeting to membrane (GO:0006612)	3.46744708
42	cytochrome complex assembly (GO:0017004)	3.43704927
43	hydrogen transport (GO:0006818)	3.42213502
44	protein complex disassembly (GO:0043241)	3.37852138
45	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.34861260
46	cellular component biogenesis (GO:0044085)	3.28538278
47	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.24070378
48	macromolecular complex disassembly (GO:0032984)	3.23004828
49	peptidyl-histidine modification (GO:0018202)	3.19892474
50	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.15761300
51	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.08427937
52	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.06660421
53	GTP biosynthetic process (GO:0006183)	3.04458035
54	regulation of cellular respiration (GO:0043457)	3.04453886
55	exocrine pancreas development (GO:0031017)	3.03165076
56	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.02406757
57	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.01773520
58	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.01515015
59	ATP biosynthetic process (GO:0006754)	3.00585641
60	ribonucleoprotein complex biogenesis (GO:0022613)	2.98772354
61	tongue development (GO:0043586)	2.97237259
62	regulation of immunoglobulin secretion (GO:0051023)	2.95156227
63	mRNA catabolic process (GO:0006402)	2.88837752
64	response to pheromone (GO:0019236)	2.88760274
65	intracellular protein transmembrane import (GO:0044743)	2.86819649
66	DNA demethylation (GO:0080111)	2.85949768
67	platelet dense granule organization (GO:0060155)	2.84888911
68	somite development (GO:0061053)	2.82833257
69	mannosylation (GO:0097502)	2.81163156
70	kinetochore assembly (GO:0051382)	2.74297171
71	proteasome assembly (GO:0043248)	2.73466741
72	negative regulation of heart rate (GO:0010459)	2.72890494
73	termination of RNA polymerase III transcription (GO:0006386)	2.70586754
74	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.70586754
75	rRNA processing (GO:0006364)	2.70251979
76	rRNA metabolic process (GO:0016072)	2.69962223
77	regulation of chronic inflammatory response (GO:0002676)	2.69543589
78	aldehyde catabolic process (GO:0046185)	2.67776347
79	kynurenine metabolic process (GO:0070189)	2.67574582
80	oxidative demethylation (GO:0070989)	2.67520771
81	positive regulation of defense response to virus by host (GO:0002230)	2.66700175
82	preassembly of GPI anchor in ER membrane (GO:0016254)	2.65856032
83	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.64704985
84	protein polyglutamylation (GO:0018095)	2.63553143
85	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.63229118
86	RNA catabolic process (GO:0006401)	2.59140473
87	epithelial cilium movement (GO:0003351)	2.58090884
88	positive regulation of respiratory burst (GO:0060267)	2.57514558
89	indole-containing compound catabolic process (GO:0042436)	2.56005800
90	indolalkylamine catabolic process (GO:0046218)	2.56005800
91	tryptophan catabolic process (GO:0006569)	2.56005800
92	L-fucose catabolic process (GO:0042355)	2.55881920
93	fucose catabolic process (GO:0019317)	2.55881920
94	L-fucose metabolic process (GO:0042354)	2.55881920
95	response to xenobiotic stimulus (GO:0009410)	2.55232686
96	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.52864754
97	ATP hydrolysis coupled proton transport (GO:0015991)	2.52864754
98	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.51931474
99	spliceosomal complex assembly (GO:0000245)	2.51161312
100	regulation of isotype switching to IgG isotypes (GO:0048302)	2.49325610

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.23961895
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.94827822
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.52163270
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.51251780
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.49967521
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.95876859
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.95549017
8	VDR_22108803_ChIP-Seq_LS180_Human	2.75256293
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.72768420
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.57690542
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.53154101
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.44737038
13	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.09872880
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.04045661
15	VDR_23849224_ChIP-Seq_CD4+_Human	1.97070638
16	IRF1_19129219_ChIP-ChIP_H3396_Human	1.91199657
17	TP53_22573176_ChIP-Seq_HFKS_Human	1.87220271
18	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.83831785
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.78493845
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.76438237
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.72366807
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.70582486
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69023165
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.65631687
25	EWS_26573619_Chip-Seq_HEK293_Human	1.65467212
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.63724058
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.55258128
28	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.54705591
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.49081545
30	AR_21572438_ChIP-Seq_LNCaP_Human	1.48917106
31	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.47801269
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.47328192
33	IGF1R_20145208_ChIP-Seq_DFB_Human	1.40899243
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.37822022
35	FUS_26573619_Chip-Seq_HEK293_Human	1.37760703
36	TTF2_22483619_ChIP-Seq_HELA_Human	1.37754952
37	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35266949
38	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35266949
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33382776
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.33372231
41	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.32880297
42	P300_19829295_ChIP-Seq_ESCs_Human	1.31318127
43	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.31182516
44	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.30509937
45	MYC_19829295_ChIP-Seq_ESCs_Human	1.28551650
46	TAF2_19829295_ChIP-Seq_ESCs_Human	1.28454823
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27788897
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.27788897
49	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.27502966
50	HOXB7_26014856_ChIP-Seq_BT474_Human	1.27397543
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.27194642
52	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.24932851
53	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.22056850
54	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.21312501
55	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.20051203
56	NCOR_22424771_ChIP-Seq_293T_Human	1.18813644
57	NANOG_20526341_ChIP-Seq_ESCs_Human	1.18208110
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16989133
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16989133
60	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.16847911
61	ERG_20517297_ChIP-Seq_VCAP_Human	1.16615992
62	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.14845575
63	GATA3_26560356_Chip-Seq_TH2_Human	1.14472258
64	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.12508852
65	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.10122349
66	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.08722821
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.07044803
68	TAF15_26573619_Chip-Seq_HEK293_Human	1.06132227
69	AR_20517297_ChIP-Seq_VCAP_Human	1.06064599
70	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.05941132
71	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.04751049
72	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.04091081
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.04036551
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02694681
75	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01374080
76	GABP_19822575_ChIP-Seq_HepG2_Human	1.00249998
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99394931
78	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.98495874
79	ERA_21632823_ChIP-Seq_H3396_Human	0.96907290
80	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.94366155
81	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.94147472
82	ER_23166858_ChIP-Seq_MCF-7_Human	0.93350356
83	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.93189407
84	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.92859302
85	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.92118558
86	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.92105650
87	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.92013906
88	CTCF_20526341_ChIP-Seq_ESCs_Human	0.90509526
89	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.88777429
90	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.87597691
91	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.86955154
92	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.84949717
93	GBX2_23144817_ChIP-Seq_PC3_Human	0.84902972
94	P53_21459846_ChIP-Seq_SAOS-2_Human	0.84731641
95	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.84642822
96	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.83188571
97	REST_21632747_ChIP-Seq_MESCs_Mouse	0.82847713
98	OCT4_20526341_ChIP-Seq_ESCs_Human	0.82463882
99	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.79963256
100	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.79930959

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002254_reproductive_system_inflammat	3.97469183
2	MP0006292_abnormal_olfactory_placode	3.89261206
3	MP0005377_hearing/vestibular/ear_phenot	3.77191217
4	MP0003878_abnormal_ear_physiology	3.77191217
5	MP0009379_abnormal_foot_pigmentation	3.69209891
6	MP0008877_abnormal_DNA_methylation	2.75556583
7	MP0001348_abnormal_lacrimal_gland	2.73116640
8	MP0002876_abnormal_thyroid_physiology	2.72329582
9	MP0008872_abnormal_physiological_respon	2.62984158
10	MP0000372_irregular_coat_pigmentation	2.33238341
11	MP0005671_abnormal_response_to	2.17237089
12	MP0004142_abnormal_muscle_tone	2.08369805
13	MP0003880_abnormal_central_pattern	2.03201016
14	MP0008875_abnormal_xenobiotic_pharmacok	2.01564385
15	MP0002102_abnormal_ear_morphology	1.98698943
16	MP0000685_abnormal_immune_system	1.93511374
17	MP0003122_maternal_imprinting	1.86949122
18	MP0001873_stomach_inflammation	1.84696052
19	MP0001293_anophthalmia	1.84211601
20	MP0002163_abnormal_gland_morphology	1.65988891
21	MP0001346_abnormal_lacrimal_gland	1.62434642
22	MP0001485_abnormal_pinna_reflex	1.62407430
23	MP0006276_abnormal_autonomic_nervous	1.57606929
24	MP0006072_abnormal_retinal_apoptosis	1.57602902
25	MP0000427_abnormal_hair_cycle	1.53091421
26	MP0003787_abnormal_imprinting	1.51798445
27	MP0002234_abnormal_pharynx_morphology	1.49486932
28	MP0005551_abnormal_eye_electrophysiolog	1.46337852
29	MP0003186_abnormal_redox_activity	1.42789583
30	MP0001835_abnormal_antigen_presentation	1.41882997
31	MP0001968_abnormal_touch/_nociception	1.40658950
32	MP0004885_abnormal_endolymph	1.37319197
33	MP0003646_muscle_fatigue	1.36320724
34	MP0001905_abnormal_dopamine_level	1.34491236
35	MP0002653_abnormal_ependyma_morphology	1.33615382
36	MP0008995_early_reproductive_senescence	1.33199041
37	MP0004145_abnormal_muscle_electrophysio	1.32361497
38	MP0008789_abnormal_olfactory_epithelium	1.32339433
39	MP0001529_abnormal_vocalization	1.29915150
40	MP0004019_abnormal_vitamin_homeostasis	1.25089981
41	MP0003195_calcinosis	1.22192068
42	MP0004133_heterotaxia	1.18586683
43	MP0004742_abnormal_vestibular_system	1.16369468
44	MP0002938_white_spotting	1.16272953
45	MP0001986_abnormal_taste_sensitivity	1.15245765
46	MP0001984_abnormal_olfaction	1.14758055
47	MP0002736_abnormal_nociception_after	1.10694740
48	MP0001501_abnormal_sleep_pattern	1.09354556
49	MP0000631_abnormal_neuroendocrine_gland	1.08707485
50	MP0001790_abnormal_immune_system	1.08580411
51	MP0005387_immune_system_phenotype	1.08580411
52	MP0003806_abnormal_nucleotide_metabolis	1.04399939
53	MP0004147_increased_porphyrin_level	1.03761619
54	MP0001440_abnormal_grooming_behavior	1.01557284
55	MP0006082_CNS_inflammation	1.00577853
56	MP0003121_genomic_imprinting	1.00267296
57	MP0002272_abnormal_nervous_system	0.98616685
58	MP0002733_abnormal_thermal_nociception	0.98399419
59	MP0001970_abnormal_pain_threshold	0.98256714
60	MP0005408_hypopigmentation	0.97244671
61	MP0005253_abnormal_eye_physiology	0.97017166
62	MP0005499_abnormal_olfactory_system	0.96076085
63	MP0005394_taste/olfaction_phenotype	0.96076085
64	MP0005645_abnormal_hypothalamus_physiol	0.95629381
65	MP0005636_abnormal_mineral_homeostasis	0.95079581
66	MP0001765_abnormal_ion_homeostasis	0.94561633
67	MP0003938_abnormal_ear_development	0.93950942
68	MP0000566_synostosis	0.93217554
69	MP0006036_abnormal_mitochondrial_physio	0.92927121
70	MP0004043_abnormal_pH_regulation	0.92816223
71	MP0005379_endocrine/exocrine_gland_phen	0.92670749
72	MP0001486_abnormal_startle_reflex	0.92036646
73	MP0002837_dystrophic_cardiac_calcinosis	0.91927347
74	MP0006035_abnormal_mitochondrial_morpho	0.91921969
75	MP0009745_abnormal_behavioral_response	0.89837700
76	MP0003718_maternal_effect	0.89824889
77	MP0001800_abnormal_humoral_immune	0.87824429
78	MP0002277_abnormal_respiratory_mucosa	0.87352964
79	MP0005075_abnormal_melanosome_morpholog	0.87266209
80	MP0005195_abnormal_posterior_eye	0.87045048
81	MP0002138_abnormal_hepatobiliary_system	0.86525945
82	MP0001919_abnormal_reproductive_system	0.85733260
83	MP0009764_decreased_sensitivity_to	0.84901661
84	MP0000026_abnormal_inner_ear	0.83552971
85	MP0002557_abnormal_social/conspecific_i	0.82627890
86	MP0005646_abnormal_pituitary_gland	0.82003998
87	MP0005389_reproductive_system_phenotype	0.81036760
88	MP0002148_abnormal_hypersensitivity_rea	0.79931754
89	MP0003786_premature_aging	0.79828896
90	MP0000778_abnormal_nervous_system	0.79450390
91	MP0003136_yellow_coat_color	0.79241384
92	MP0002210_abnormal_sex_determination	0.77177339
93	MP0000647_abnormal_sebaceous_gland	0.77069689
94	MP0005410_abnormal_fertilization	0.75551156
95	MP0001963_abnormal_hearing_physiology	0.75398988
96	MP0003638_abnormal_response/metabolism_	0.73747286
97	MP0001727_abnormal_embryo_implantation	0.72294071
98	MP0002638_abnormal_pupillary_reflex	0.70035253
99	MP0000383_abnormal_hair_follicle	0.69704041
100	MP0000049_abnormal_middle_ear	0.69045133

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.62376496
2	Increased circulating renin level (HP:0000848)	4.50851676
3	Mitochondrial inheritance (HP:0001427)	4.05709447
4	Polydipsia (HP:0001959)	4.05146874
5	Abnormal drinking behavior (HP:0030082)	4.05146874
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.93018357
7	Acute encephalopathy (HP:0006846)	3.92183619
8	3-Methylglutaconic aciduria (HP:0003535)	3.85000092
9	Progressive macrocephaly (HP:0004481)	3.79159809
10	Hypomagnesemia (HP:0002917)	3.77368448
11	Abnormality of midbrain morphology (HP:0002418)	3.76876762
12	Molar tooth sign on MRI (HP:0002419)	3.76876762
13	Hepatocellular necrosis (HP:0001404)	3.74414024
14	Reticulocytopenia (HP:0001896)	3.70992519
15	Increased CSF lactate (HP:0002490)	3.66291093
16	Tetany (HP:0001281)	3.63756370
17	Abnormality of cells of the erythroid lineage (HP:0012130)	3.41895411
18	Nephronophthisis (HP:0000090)	3.40917459
19	Aplasia/Hypoplasia of the spleen (HP:0010451)	3.37413287
20	Asplenia (HP:0001746)	3.21730265
21	Abnormality of magnesium homeostasis (HP:0004921)	3.20716623
22	Hepatic necrosis (HP:0002605)	3.15999934
23	Hypokalemic alkalosis (HP:0001949)	3.11514294
24	Pancreatic cysts (HP:0001737)	3.08612164
25	Increased hepatocellular lipid droplets (HP:0006565)	2.97170238
26	Stomatitis (HP:0010280)	2.94693630
27	Pancreatic fibrosis (HP:0100732)	2.89813553
28	Polyuria (HP:0000103)	2.86749584
29	Optic disc pallor (HP:0000543)	2.82364611
30	Lipid accumulation in hepatocytes (HP:0006561)	2.76997122
31	Type II lissencephaly (HP:0007260)	2.76950899
32	Abnormal number of erythroid precursors (HP:0012131)	2.75413770
33	Bilateral sensorineural hearing impairment (HP:0008619)	2.74153960
34	Cerebral edema (HP:0002181)	2.70973556
35	IgG deficiency (HP:0004315)	2.69708902
36	Abnormality of the renal medulla (HP:0100957)	2.61896839
37	Increased IgM level (HP:0003496)	2.58297070
38	Congenital, generalized hypertrichosis (HP:0004540)	2.53238272
39	Abnormality of renin-angiotensin system (HP:0000847)	2.52898838
40	Increased serum lactate (HP:0002151)	2.46272246
41	Amelogenesis imperfecta (HP:0000705)	2.46174887
42	Abnormality of the labia minora (HP:0012880)	2.43994039
43	Congenital stationary night blindness (HP:0007642)	2.43956015
44	Stenosis of the external auditory canal (HP:0000402)	2.43543074
45	Septo-optic dysplasia (HP:0100842)	2.42730239
46	Macrocytic anemia (HP:0001972)	2.41157009
47	True hermaphroditism (HP:0010459)	2.39471469
48	Renal Fanconi syndrome (HP:0001994)	2.33340203
49	Abnormal urine output (HP:0012590)	2.32398119
50	Conical tooth (HP:0000698)	2.30515976
51	Leukodystrophy (HP:0002415)	2.27684845
52	Hypoplasia of the pons (HP:0012110)	2.24768183
53	Paralysis (HP:0003470)	2.23430484
54	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.22000019
55	Abnormality of the renal cortex (HP:0011035)	2.19949769
56	Tubular atrophy (HP:0000092)	2.18711199
57	Sclerocornea (HP:0000647)	2.18641922
58	Colon cancer (HP:0003003)	2.18510028
59	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.17653655
60	Abnormal respiratory epithelium morphology (HP:0012253)	2.15473203
61	Abnormal respiratory motile cilium morphology (HP:0005938)	2.15473203
62	Increased intramyocellular lipid droplets (HP:0012240)	2.15111068
63	Abnormality of the pons (HP:0007361)	2.14828456
64	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.13807447
65	Abnormality of alanine metabolism (HP:0010916)	2.13807447
66	Hyperalaninemia (HP:0003348)	2.13807447
67	Abnormality of renal excretion (HP:0011036)	2.12561489
68	Respiratory failure (HP:0002878)	2.12225999
69	Lactic acidosis (HP:0003128)	2.09611659
70	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.05820935
71	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.05820935
72	Abnormal rod and cone electroretinograms (HP:0008323)	2.04687320
73	Cerebellar dysplasia (HP:0007033)	2.03562327
74	Abnormality of dental color (HP:0011073)	2.02740318
75	Abolished electroretinogram (ERG) (HP:0000550)	2.02390853
76	Rib fusion (HP:0000902)	2.01394522
77	Pallor (HP:0000980)	1.98806428
78	Exertional dyspnea (HP:0002875)	1.98162950
79	Hypoplasia of the ulna (HP:0003022)	1.96374686
80	Alkalosis (HP:0001948)	1.95120441
81	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.92780947
82	Abnormal ciliary motility (HP:0012262)	1.92550673
83	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.91547151
84	Medial flaring of the eyebrow (HP:0010747)	1.89900654
85	Renal cortical cysts (HP:0000803)	1.87347016
86	Exercise intolerance (HP:0003546)	1.83639570
87	Absent thumb (HP:0009777)	1.81438146
88	Severe muscular hypotonia (HP:0006829)	1.81007074
89	Absent/shortened dynein arms (HP:0200106)	1.78985603
90	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.78985603
91	Absent septum pellucidum (HP:0001331)	1.78869773
92	Hypokalemia (HP:0002900)	1.76817806
93	Cystic liver disease (HP:0006706)	1.76678922
94	Lethargy (HP:0001254)	1.76677738
95	Aplasia/hypoplasia of the uterus (HP:0008684)	1.73726772
96	Increased muscle lipid content (HP:0009058)	1.71387787
97	Woolly hair (HP:0002224)	1.70846304
98	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.69845933
99	Abnormal respiratory motile cilium physiology (HP:0012261)	1.69692263
100	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.69367124

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	8.71731996
2	STK39	7.19534091
3	OXSR1	5.25389400
4	TNIK	2.37847026
5	MAP4K2	2.14299226
6	TLK1	1.89753491
7	ADRBK2	1.84240250
8	ZAK	1.83415139
9	MAP3K12	1.79843457
10	PINK1	1.74081667
11	NUAK1	1.66860296
12	TXK	1.62451475
13	TAOK3	1.53473738
14	GRK1	1.51078936
15	TSSK6	1.48219481
16	FRK	1.38029654
17	WNK3	1.33649361
18	EPHA4	1.30765959
19	VRK2	1.24319522
20	NME1	1.22800470
21	STK16	1.11847418
22	INSRR	1.09064351
23	DYRK2	1.06664761
24	SRPK1	1.00346587
25	MAP2K7	0.96850728
26	MAP3K11	0.95502245
27	BCKDK	0.95081654
28	EIF2AK1	0.90256121
29	PIK3CA	0.90163962
30	PAK3	0.88658653
31	BMPR1B	0.86987383
32	MAP3K4	0.86891682
33	CDK19	0.85897716
34	WNK1	0.85559465
35	PLK2	0.84197779
36	MKNK2	0.81131007
37	MST4	0.77917514
38	PASK	0.76416534
39	NEK1	0.69983049
40	MAPK13	0.69849475
41	BMPR2	0.67785154
42	PHKG1	0.67536301
43	PHKG2	0.67536301
44	ADRBK1	0.67135661
45	FGFR2	0.61617139
46	VRK1	0.60741657
47	PTK2B	0.58243617
48	IKBKB	0.55562233
49	TIE1	0.52597235
50	LRRK2	0.50265196
51	CAMKK2	0.49667603
52	ERBB3	0.49366648
53	MAP4K1	0.46852191
54	MATK	0.46590241
55	PRKD3	0.45503001
56	DAPK3	0.45394115
57	MYLK	0.44897905
58	PLK3	0.42437883
59	PRKCG	0.40832031
60	TAF1	0.38752088
61	TEC	0.37727845
62	MAP2K6	0.36336929
63	PRKCQ	0.35881174
64	PRKCE	0.35545719
65	AURKB	0.34800965
66	KDR	0.34791217
67	NTRK1	0.34460699
68	TRIM28	0.32706633
69	PRKACA	0.32294752
70	MUSK	0.31775144
71	PLK1	0.31492977
72	PDK2	0.29498000
73	OBSCN	0.28934745
74	MKNK1	0.28873480
75	LCK	0.28473241
76	PRKCA	0.28074655
77	ITK	0.27837118
78	PRKG2	0.26832421
79	CSNK2A2	0.26688799
80	PKN1	0.25234488
81	STK38L	0.24930190
82	ILK	0.24467856
83	TNK2	0.24283174
84	CSNK2A1	0.24106736
85	NLK	0.23895485
86	PRKCI	0.22338714
87	PRKCD	0.22295443
88	MARK3	0.22162042
89	GRK7	0.22009073
90	BUB1	0.21185070
91	SYK	0.20317154
92	FES	0.20255421
93	CSNK1E	0.19974875
94	GRK5	0.19819103
95	CAMK1	0.19289610
96	CSNK1G2	0.19187216
97	PLK4	0.18877095
98	MAP2K4	0.18567976
99	AURKA	0.18086279
100	FGFR1	0.17718445

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.80237847
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.44547558
3	Parkinsons disease_Homo sapiens_hsa05012	3.29246839
4	Asthma_Homo sapiens_hsa05310	2.94965903
5	Proteasome_Homo sapiens_hsa03050	2.93711410
6	Caffeine metabolism_Homo sapiens_hsa00232	2.50055382
7	Collecting duct acid secretion_Homo sapiens_hsa04966	2.42809687
8	Huntingtons disease_Homo sapiens_hsa05016	2.35318719
9	Alzheimers disease_Homo sapiens_hsa05010	2.31248405
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.25950823
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.25370070
12	Allograft rejection_Homo sapiens_hsa05330	2.20435779
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.15934592
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.09763007
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.07819467
16	Protein export_Homo sapiens_hsa03060	2.07134685
17	RNA polymerase_Homo sapiens_hsa03020	2.07116481
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.94172514
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.87776054
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.61462942
21	Basal transcription factors_Homo sapiens_hsa03022	1.58809835
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.56193565
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.54590939
24	RNA degradation_Homo sapiens_hsa03018	1.52219297
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.50627252
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.49762552
27	Graft-versus-host disease_Homo sapiens_hsa05332	1.45777853
28	Phototransduction_Homo sapiens_hsa04744	1.39653838
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.14656601
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.13629232
31	Peroxisome_Homo sapiens_hsa04146	1.10152881
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.09302678
33	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.05038074
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.00592616
35	Olfactory transduction_Homo sapiens_hsa04740	1.00052800
36	Homologous recombination_Homo sapiens_hsa03440	0.99070023
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.97582899
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.97022845
39	Nucleotide excision repair_Homo sapiens_hsa03420	0.95945887
40	Chemical carcinogenesis_Homo sapiens_hsa05204	0.92809846
41	One carbon pool by folate_Homo sapiens_hsa00670	0.91107143
42	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.90853977
43	Tryptophan metabolism_Homo sapiens_hsa00380	0.88457281
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.88232768
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.85851410
46	Fat digestion and absorption_Homo sapiens_hsa04975	0.84325996
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.84224365
48	Nitrogen metabolism_Homo sapiens_hsa00910	0.79058343
49	Propanoate metabolism_Homo sapiens_hsa00640	0.78749430
50	Folate biosynthesis_Homo sapiens_hsa00790	0.78630525
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78607583
52	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.77369828
53	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.76208254
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.75549388
55	Spliceosome_Homo sapiens_hsa03040	0.73692747
56	RNA transport_Homo sapiens_hsa03013	0.73228427
57	Nicotine addiction_Homo sapiens_hsa05033	0.72284494
58	Butanoate metabolism_Homo sapiens_hsa00650	0.70841023
59	Antigen processing and presentation_Homo sapiens_hsa04612	0.68592295
60	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.68402424
61	Metabolic pathways_Homo sapiens_hsa01100	0.68372470
62	Purine metabolism_Homo sapiens_hsa00230	0.67860057
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.67513075
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67089257
65	Retinol metabolism_Homo sapiens_hsa00830	0.62034791
66	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.61307981
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59394826
68	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.59389312
69	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.57763720
70	Mismatch repair_Homo sapiens_hsa03430	0.56040600
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53858112
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52869580
73	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50689972
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.50246308
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49557351
76	Sulfur metabolism_Homo sapiens_hsa00920	0.48624544
77	Non-homologous end-joining_Homo sapiens_hsa03450	0.48028578
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.45564563
79	Sulfur relay system_Homo sapiens_hsa04122	0.45109447
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43109956
81	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.42957070
82	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.42007939
83	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.41384651
84	Base excision repair_Homo sapiens_hsa03410	0.35067958
85	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.33979886
86	Steroid biosynthesis_Homo sapiens_hsa00100	0.33722051
87	DNA replication_Homo sapiens_hsa03030	0.33582512
88	Taste transduction_Homo sapiens_hsa04742	0.33247359
89	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.33041294
90	Regulation of autophagy_Homo sapiens_hsa04140	0.32023277
91	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.31354301
92	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.26648260
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.26621732
94	Glutathione metabolism_Homo sapiens_hsa00480	0.26084906
95	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.24354000
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.22408060
97	Fatty acid degradation_Homo sapiens_hsa00071	0.22142924
98	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.20407104
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.18189261
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.18122975

RPL21P106

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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