ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ATP synthesis coupled proton transport (GO:0015986)	5.29442185
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.29442185
3	ribosomal small subunit assembly (GO:0000028)	5.18744221
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.10235908
5	ribosomal large subunit biogenesis (GO:0042273)	4.75897554
6	DNA deamination (GO:0045006)	4.57537602
7	viral transcription (GO:0019083)	4.43772893
8	translational termination (GO:0006415)	4.27453216
9	sleep (GO:0030431)	4.27000816
10	water-soluble vitamin biosynthetic process (GO:0042364)	4.19144408
11	chaperone-mediated protein transport (GO:0072321)	4.02288492
12	rRNA modification (GO:0000154)	3.97805343
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.90130143
14	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.90130143
15	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.89867524
16	cellular response to exogenous dsRNA (GO:0071360)	3.87104438
17	translational elongation (GO:0006414)	3.86744110
18	cotranslational protein targeting to membrane (GO:0006613)	3.83413442
19	protein targeting to ER (GO:0045047)	3.81563993
20	mannosylation (GO:0097502)	3.78096012
21	protein neddylation (GO:0045116)	3.76249174
22	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.65317108
23	protein localization to endoplasmic reticulum (GO:0070972)	3.62036727
24	ribosomal small subunit biogenesis (GO:0042274)	3.56984446
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.56018012
26	positive regulation of prostaglandin secretion (GO:0032308)	3.54596378
27	piRNA metabolic process (GO:0034587)	3.43375024
28	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.41157191
29	protein complex biogenesis (GO:0070271)	3.36705389
30	pseudouridine synthesis (GO:0001522)	3.30431029
31	respiratory chain complex IV assembly (GO:0008535)	3.29775032
32	positive regulation of defense response to virus by host (GO:0002230)	3.29208453
33	electron transport chain (GO:0022900)	3.25738087
34	respiratory electron transport chain (GO:0022904)	3.24090656
35	viral life cycle (GO:0019058)	3.23735501
36	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.23022636
37	mitochondrial respiratory chain complex assembly (GO:0033108)	3.22291362
38	translation (GO:0006412)	3.21821350
39	behavioral response to nicotine (GO:0035095)	3.21046757
40	ribonucleoprotein complex biogenesis (GO:0022613)	3.19958149
41	cellular component biogenesis (GO:0044085)	3.17156292
42	cytochrome complex assembly (GO:0017004)	3.14720264
43	translational initiation (GO:0006413)	3.12877186
44	parturition (GO:0007567)	3.12366277
45	mast cell activation (GO:0045576)	3.12168741
46	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.11366919
47	rRNA methylation (GO:0031167)	3.09910100
48	cellular protein complex disassembly (GO:0043624)	3.09741960
49	positive regulation of fatty acid transport (GO:2000193)	3.04690381
50	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.04142853
51	termination of RNA polymerase III transcription (GO:0006386)	3.03734354
52	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.03734354
53	preassembly of GPI anchor in ER membrane (GO:0016254)	3.01480355
54	protein-cofactor linkage (GO:0018065)	3.00659117
55	maturation of SSU-rRNA (GO:0030490)	3.00341634
56	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.98319211
57	tolerance induction (GO:0002507)	2.95634534
58	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.95578127
59	NADH dehydrogenase complex assembly (GO:0010257)	2.95578127
60	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.95578127
61	positive regulation of icosanoid secretion (GO:0032305)	2.95471630
62	regulation of mitotic spindle checkpoint (GO:1903504)	2.92614908
63	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.92614908
64	negative regulation of mast cell activation (GO:0033004)	2.91887676
65	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.90441345
66	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.89695531
67	tRNA processing (GO:0008033)	2.88795288
68	peptidyl-histidine modification (GO:0018202)	2.87232404
69	ATP biosynthetic process (GO:0006754)	2.84954800
70	GPI anchor metabolic process (GO:0006505)	2.83770814
71	regulation of regulatory T cell differentiation (GO:0045589)	2.82414249
72	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.80621000
73	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.78608896
74	GPI anchor biosynthetic process (GO:0006506)	2.76495554
75	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.74792580
76	kynurenine metabolic process (GO:0070189)	2.74749833
77	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.72303605
78	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.72303605
79	isotype switching (GO:0045190)	2.72303605
80	S-adenosylmethionine metabolic process (GO:0046500)	2.72188029
81	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.72141958
82	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.71780222
83	base-excision repair, AP site formation (GO:0006285)	2.71347505
84	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.70537692
85	amino acid salvage (GO:0043102)	2.70363039
86	L-methionine salvage (GO:0071267)	2.70363039
87	L-methionine biosynthetic process (GO:0071265)	2.70363039
88	hydrogen ion transmembrane transport (GO:1902600)	2.69958860
89	mast cell degranulation (GO:0043303)	2.69129897
90	mast cell activation involved in immune response (GO:0002279)	2.69129897
91	rRNA metabolic process (GO:0016072)	2.68818714
92	GTP biosynthetic process (GO:0006183)	2.66897298
93	regulation of prostaglandin secretion (GO:0032306)	2.66613820
94	regulation of defense response to virus by host (GO:0050691)	2.66403322
95	negative regulation of telomere maintenance (GO:0032205)	2.65565769
96	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.65289926
97	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.64682483
98	rRNA processing (GO:0006364)	2.64401680
99	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.64234124
100	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.63926876

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.90992073
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.54752389
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.54515892
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.76012975
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.63627277
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.09900480
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.92772540
8	VDR_22108803_ChIP-Seq_LS180_Human	2.86292724
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.72676904
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.55811994
11	FOXP3_21729870_ChIP-Seq_TREG_Human	2.50457267
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.48928762
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.32252427
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.30693674
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.21980083
16	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.21954780
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.20170018
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.15646391
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.08120390
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.05414575
21	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.00565612
22	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.96817633
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.95290692
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.91239079
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.86532091
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.83144555
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.78558113
28	GATA3_26560356_Chip-Seq_TH2_Human	1.75220327
29	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.72426746
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71492041
31	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.69728630
32	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.61278153
33	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.58474771
34	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.58320848
35	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.53594786
36	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.53403962
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51448761
38	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.45769797
39	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.45745589
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.45577106
41	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.45365052
42	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.43705265
43	FUS_26573619_Chip-Seq_HEK293_Human	1.42596809
44	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.42169170
45	AR_20517297_ChIP-Seq_VCAP_Human	1.41411026
46	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.34872487
47	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.31373789
48	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.30521140
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29172472
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29172472
51	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.22571635
52	EWS_26573619_Chip-Seq_HEK293_Human	1.22291431
53	TTF2_22483619_ChIP-Seq_HELA_Human	1.22102170
54	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.21543354
55	NCOR_22424771_ChIP-Seq_293T_Human	1.21160281
56	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.20750346
57	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.14306804
58	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.13351833
59	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.12490724
60	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12181346
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11467180
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11467180
63	IGF1R_20145208_ChIP-Seq_DFB_Human	1.11325284
64	ER_23166858_ChIP-Seq_MCF-7_Human	1.11303438
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10855081
66	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.10643877
67	GABP_19822575_ChIP-Seq_HepG2_Human	1.10498439
68	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.10456689
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09298599
70	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.07095630
71	MYB_26560356_Chip-Seq_TH2_Human	1.06653233
72	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.06500138
73	CBP_20019798_ChIP-Seq_JUKART_Human	1.05200712
74	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.05200712
75	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.04460859
76	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.02915077
77	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02785671
78	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02756381
79	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02120397
80	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.01086006
81	ERG_20517297_ChIP-Seq_VCAP_Human	1.00365684
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99563994
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99000941
84	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.98940844
85	CIITA_25753668_ChIP-Seq_RAJI_Human	0.98632862
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97790569
87	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.97727052
88	DCP1A_22483619_ChIP-Seq_HELA_Human	0.96820896
89	HOXB7_26014856_ChIP-Seq_BT474_Human	0.96685138
90	GATA3_27048872_Chip-Seq_THYMUS_Human	0.96207777
91	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.93965905
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92966058
93	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.92411676
94	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.92009779
95	ERA_21632823_ChIP-Seq_H3396_Human	0.91901208
96	TAF2_19829295_ChIP-Seq_ESCs_Human	0.89050187
97	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.88876358
98	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.88514637
99	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.87869966
100	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.87057432

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	3.34888760
2	MP0001986_abnormal_taste_sensitivity	2.89963313
3	MP0002876_abnormal_thyroid_physiology	2.89610790
4	MP0005671_abnormal_response_to	2.86927576
5	MP0008877_abnormal_DNA_methylation	2.85853754
6	MP0006072_abnormal_retinal_apoptosis	2.83860885
7	MP0008875_abnormal_xenobiotic_pharmacok	2.79823368
8	MP0003724_increased_susceptibility_to	2.70897891
9	MP0001835_abnormal_antigen_presentation	2.62509182
10	MP0005075_abnormal_melanosome_morpholog	2.55557497
11	MP0002638_abnormal_pupillary_reflex	2.36831294
12	MP0004147_increased_porphyrin_level	2.27687696
13	MP0006292_abnormal_olfactory_placode	2.25364738
14	MP0008872_abnormal_physiological_respon	2.19449659
15	MP0002102_abnormal_ear_morphology	2.15164745
16	MP0000569_abnormal_digit_pigmentation	2.10543441
17	MP0002148_abnormal_hypersensitivity_rea	2.08196869
18	MP0002938_white_spotting	2.03250776
19	MP0009785_altered_susceptibility_to	2.00898932
20	MP0000685_abnormal_immune_system	1.95461213
21	MP0000372_irregular_coat_pigmentation	1.89308695
22	MP0005000_abnormal_immune_tolerance	1.86756444
23	MP0009379_abnormal_foot_pigmentation	1.86598217
24	MP0005646_abnormal_pituitary_gland	1.85709689
25	MP0003866_abnormal_defecation	1.85255643
26	MP0002736_abnormal_nociception_after	1.80982060
27	MP0001800_abnormal_humoral_immune	1.76024552
28	MP0001968_abnormal_touch/_nociception	1.65486301
29	MP0002138_abnormal_hepatobiliary_system	1.58062021
30	MP0002723_abnormal_immune_serum	1.53430740
31	MP0006036_abnormal_mitochondrial_physio	1.52783806
32	MP0001919_abnormal_reproductive_system	1.50675953
33	MP0008058_abnormal_DNA_repair	1.44652102
34	MP0002166_altered_tumor_susceptibility	1.43997762
35	MP0005389_reproductive_system_phenotype	1.42560510
36	MP0004885_abnormal_endolymph	1.41970521
37	MP0002006_tumorigenesis	1.41692476
38	MP0003880_abnormal_central_pattern	1.40676666
39	MP0002452_abnormal_antigen_presenting	1.40031526
40	MP0005174_abnormal_tail_pigmentation	1.38984571
41	MP0005551_abnormal_eye_electrophysiolog	1.38337445
42	MP0003786_premature_aging	1.36642532
43	MP0005253_abnormal_eye_physiology	1.36461259
44	MP0001501_abnormal_sleep_pattern	1.36394444
45	MP0009764_decreased_sensitivity_to	1.36282040
46	MP0003195_calcinosis	1.36223277
47	MP0001819_abnormal_immune_cell	1.27193028
48	MP0002420_abnormal_adaptive_immunity	1.25872538
49	MP0003718_maternal_effect	1.25376047
50	MP0003763_abnormal_thymus_physiology	1.24231217
51	MP0003436_decreased_susceptibility_to	1.22513258
52	MP0000465_gastrointestinal_hemorrhage	1.18439995
53	MP0005084_abnormal_gallbladder_morpholo	1.17506414
54	MP0008775_abnormal_heart_ventricle	1.16567999
55	MP0004145_abnormal_muscle_electrophysio	1.16323668
56	MP0010155_abnormal_intestine_physiology	1.13862835
57	MP0001905_abnormal_dopamine_level	1.09128881
58	MP0004142_abnormal_muscle_tone	1.08959055
59	MP0006276_abnormal_autonomic_nervous	1.08667963
60	MP0005377_hearing/vestibular/ear_phenot	1.08510953
61	MP0003878_abnormal_ear_physiology	1.08510953
62	MP0009333_abnormal_splenocyte_physiolog	1.08150127
63	MP0001845_abnormal_inflammatory_respons	1.07887170
64	MP0001765_abnormal_ion_homeostasis	1.07654561
65	MP0004043_abnormal_pH_regulation	1.02714421
66	MP0005387_immune_system_phenotype	1.02321539
67	MP0001790_abnormal_immune_system	1.02321539
68	MP0002272_abnormal_nervous_system	1.01522815
69	MP0002095_abnormal_skin_pigmentation	1.01118010
70	MP0005332_abnormal_amino_acid	1.00970322
71	MP0002160_abnormal_reproductive_system	1.00007699
72	MP0005410_abnormal_fertilization	0.99571322
73	MP0005636_abnormal_mineral_homeostasis	0.92363118
74	MP0005025_abnormal_response_to	0.92021736
75	MP0009745_abnormal_behavioral_response	0.90372489
76	MP0005085_abnormal_gallbladder_physiolo	0.88760667
77	MP0003011_delayed_dark_adaptation	0.87735834
78	MP0000230_abnormal_systemic_arterial	0.87640686
79	MP0002398_abnormal_bone_marrow	0.87081979
80	MP0000716_abnormal_immune_system	0.86198727
81	MP0003186_abnormal_redox_activity	0.84796433
82	MP0005645_abnormal_hypothalamus_physiol	0.82961393
83	MP0000689_abnormal_spleen_morphology	0.82713389
84	MP0008995_early_reproductive_senescence	0.82241660
85	MP0000427_abnormal_hair_cycle	0.80841937
86	MP0001440_abnormal_grooming_behavior	0.78063382
87	MP0002419_abnormal_innate_immunity	0.77391411
88	MP0002722_abnormal_immune_system	0.76287491
89	MP0001533_abnormal_skeleton_physiology	0.75157485
90	MP0003693_abnormal_embryo_hatching	0.74948597
91	MP0001293_anophthalmia	0.73900306
92	MP0001853_heart_inflammation	0.73672721
93	MP0003252_abnormal_bile_duct	0.73457484
94	MP0008469_abnormal_protein_level	0.71655053
95	MP0002234_abnormal_pharynx_morphology	0.71288689
96	MP0002429_abnormal_blood_cell	0.69636156
97	MP0002837_dystrophic_cardiac_calcinosis	0.69569153
98	MP0000703_abnormal_thymus_morphology	0.68924661
99	MP0009643_abnormal_urine_homeostasis	0.68583880
100	MP0000015_abnormal_ear_pigmentation	0.68424983

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.00747472
2	Abnormality of cells of the erythroid lineage (HP:0012130)	3.86310637
3	IgG deficiency (HP:0004315)	3.80481948
4	Elevated erythrocyte sedimentation rate (HP:0003565)	3.51178293
5	Acute necrotizing encephalopathy (HP:0006965)	3.49634818
6	Mitochondrial inheritance (HP:0001427)	3.42759014
7	Pancreatic cysts (HP:0001737)	3.39733899
8	Abnormal number of erythroid precursors (HP:0012131)	3.33329772
9	Increased CSF lactate (HP:0002490)	3.17698689
10	Pancreatic fibrosis (HP:0100732)	3.09948891
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.08629580
12	Hepatocellular necrosis (HP:0001404)	3.08038175
13	Methylmalonic acidemia (HP:0002912)	3.04575782
14	Progressive macrocephaly (HP:0004481)	2.95839347
15	Acute encephalopathy (HP:0006846)	2.95635901
16	Congenital, generalized hypertrichosis (HP:0004540)	2.93535717
17	Congenital stationary night blindness (HP:0007642)	2.91164614
18	Hepatic necrosis (HP:0002605)	2.90026485
19	Abnormality of the prostate (HP:0008775)	2.87907245
20	Lipid accumulation in hepatocytes (HP:0006561)	2.85480599
21	True hermaphroditism (HP:0010459)	2.71843246
22	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.70304292
23	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.70304292
24	Prostate neoplasm (HP:0100787)	2.70282211
25	Renal cortical cysts (HP:0000803)	2.68713577
26	Increased hepatocellular lipid droplets (HP:0006565)	2.68337148
27	Increased serum lactate (HP:0002151)	2.66073367
28	Stomatitis (HP:0010280)	2.63962730
29	Nephronophthisis (HP:0000090)	2.63346230
30	Abnormality of the renal cortex (HP:0011035)	2.60988476
31	Type II lissencephaly (HP:0007260)	2.58014250
32	Increased intramyocellular lipid droplets (HP:0012240)	2.57494083
33	Macrocytic anemia (HP:0001972)	2.56691141
34	Methylmalonic aciduria (HP:0012120)	2.50826143
35	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.47834511
36	Stomach cancer (HP:0012126)	2.47749221
37	Absent thumb (HP:0009777)	2.45443137
38	Optic disc pallor (HP:0000543)	2.42831997
39	Abolished electroretinogram (ERG) (HP:0000550)	2.40495596
40	Lactic acidosis (HP:0003128)	2.40290931
41	Abnormality of midbrain morphology (HP:0002418)	2.37615638
42	Molar tooth sign on MRI (HP:0002419)	2.37615638
43	Parakeratosis (HP:0001036)	2.36316234
44	Increased muscle lipid content (HP:0009058)	2.31086444
45	Asplenia (HP:0001746)	2.30325957
46	Absent/shortened dynein arms (HP:0200106)	2.29925048
47	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.29925048
48	Abnormality of the renal medulla (HP:0100957)	2.27877671
49	Stenosis of the external auditory canal (HP:0000402)	2.27715577
50	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.26766042
51	Cerebral edema (HP:0002181)	2.26481345
52	Abnormality of alanine metabolism (HP:0010916)	2.21595158
53	Hyperalaninemia (HP:0003348)	2.21595158
54	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.21595158
55	Abnormality of B cell number (HP:0010975)	2.19848006
56	Abnormal rod and cone electroretinograms (HP:0008323)	2.17968359
57	Type 2 muscle fiber atrophy (HP:0003554)	2.17286865
58	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.14501279
59	Type I transferrin isoform profile (HP:0003642)	2.13779828
60	Severe combined immunodeficiency (HP:0004430)	2.12664762
61	Sclerocornea (HP:0000647)	2.12349151
62	Aplasia/hypoplasia of the uterus (HP:0008684)	2.08235594
63	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.06195422
64	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.05237206
65	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.04833458
66	Reticulocytopenia (HP:0001896)	2.03726021
67	Abnormal protein N-linked glycosylation (HP:0012347)	2.02360262
68	Abnormal protein glycosylation (HP:0012346)	2.02360262
69	Abnormal glycosylation (HP:0012345)	2.02360262
70	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.02360262
71	Abnormality of the pons (HP:0007361)	1.99487313
72	Lethargy (HP:0001254)	1.99427006
73	Renal Fanconi syndrome (HP:0001994)	1.96671950
74	Pallor (HP:0000980)	1.94398916
75	Hypoplasia of the pons (HP:0012110)	1.94396035
76	Abnormal respiratory motile cilium morphology (HP:0005938)	1.94196102
77	Abnormal respiratory epithelium morphology (HP:0012253)	1.94196102
78	Progressive microcephaly (HP:0000253)	1.94142367
79	Pendular nystagmus (HP:0012043)	1.91602071
80	Myositis (HP:0100614)	1.89410849
81	Abnormality of T cell physiology (HP:0011840)	1.88194987
82	Decreased central vision (HP:0007663)	1.87677171
83	Clubbing of toes (HP:0100760)	1.87403451
84	Panhypogammaglobulinemia (HP:0003139)	1.86803418
85	B lymphocytopenia (HP:0010976)	1.86138596
86	Exertional dyspnea (HP:0002875)	1.83720498
87	Cystic liver disease (HP:0006706)	1.81970889
88	Testicular atrophy (HP:0000029)	1.81833050
89	Abnormality of T cells (HP:0002843)	1.81453826
90	Respiratory failure (HP:0002878)	1.81228706
91	Optic neuritis (HP:0100653)	1.80829149
92	Retrobulbar optic neuritis (HP:0100654)	1.80829149
93	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.76349145
94	Hypoplasia of the uterus (HP:0000013)	1.76071332
95	Pancytopenia (HP:0001876)	1.75479331
96	Abnormal biliary tract physiology (HP:0012439)	1.74719573
97	Bile duct proliferation (HP:0001408)	1.74719573
98	Opisthotonus (HP:0002179)	1.74439463
99	Palpitations (HP:0001962)	1.74355151
100	Conical tooth (HP:0000698)	1.72693187

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.01632809
2	MAP4K2	3.89451491
3	TLK1	3.70352610
4	ZAK	3.46786593
5	NUAK1	3.44496410
6	TAOK3	3.39355925
7	STK16	2.71456508
8	ADRBK2	2.27856943
9	MAP2K2	2.26936713
10	BCKDK	2.18208568
11	NME1	2.15690695
12	MAP3K14	2.06560354
13	KIT	2.06289304
14	WNK4	2.05816876
15	MST4	2.05393568
16	PINK1	1.93722413
17	GRK1	1.86055636
18	BMPR2	1.70259647
19	TEC	1.67818076
20	VRK2	1.66491974
21	FRK	1.62977424
22	IKBKB	1.56415717
23	GRK6	1.55277806
24	CDK19	1.54094613
25	ITK	1.45986271
26	CAMKK2	1.39418638
27	IKBKE	1.30549673
28	EIF2AK3	1.22873192
29	EIF2AK2	1.22284008
30	OXSR1	1.16483596
31	BMPR1B	1.15662661
32	PHKG1	1.11540051
33	PHKG2	1.11540051
34	VRK1	1.07143187
35	MAP2K6	1.07140969
36	SYK	1.03960337
37	RIPK4	1.00791826
38	PIK3CA	0.99249535
39	TBK1	0.91683442
40	BRSK2	0.87150032
41	BTK	0.86717459
42	DYRK2	0.85249182
43	FES	0.81821190
44	CSF1R	0.77318200
45	FLT3	0.75438821
46	PDK2	0.74786420
47	PLK4	0.73761994
48	MAPK13	0.73094024
49	RPS6KB2	0.72196668
50	SRPK1	0.71399439
51	CSNK1G3	0.71360729
52	LCK	0.70997292
53	RPS6KA5	0.69633878
54	WNK3	0.68097036
55	PRKCQ	0.67505178
56	TIE1	0.66955722
57	MAPKAPK3	0.65240798
58	MAP3K13	0.64541534
59	CHUK	0.63683195
60	CDC7	0.63333337
61	LYN	0.62990325
62	EIF2AK1	0.62688971
63	GRK7	0.61697121
64	STK39	0.60689440
65	JAK1	0.59729013
66	INSRR	0.59020695
67	AURKB	0.58571451
68	IGF1R	0.56957464
69	ADRBK1	0.51230975
70	MAP4K1	0.50698559
71	BUB1	0.49380648
72	CSNK1G2	0.48690940
73	PLK3	0.48686608
74	GRK5	0.48254146
75	WNK1	0.47553909
76	MAP3K12	0.47095167
77	TNK2	0.46100990
78	MKNK1	0.45927366
79	MYLK	0.45586553
80	CSNK1G1	0.45087209
81	CDK8	0.43864899
82	PLK2	0.43243674
83	CSNK1A1L	0.42417496
84	MKNK2	0.42140748
85	ABL1	0.40541839
86	DAPK1	0.40169475
87	JAK3	0.39287894
88	LIMK1	0.38286345
89	ERBB3	0.38230283
90	MAPKAPK5	0.37960956
91	RPS6KA6	0.36904368
92	PASK	0.35558980
93	CSNK1A1	0.34237502
94	TESK2	0.32971597
95	CSNK2A2	0.32596948
96	PIM1	0.31411090
97	CSNK2A1	0.30066146
98	ATR	0.29749917
99	PLK1	0.28092264
100	OBSCN	0.27737061

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.22836830
2	Asthma_Homo sapiens_hsa05310	3.25854914
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.12652610
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.02418692
5	Allograft rejection_Homo sapiens_hsa05330	2.74701306
6	Proteasome_Homo sapiens_hsa03050	2.70038527
7	Parkinsons disease_Homo sapiens_hsa05012	2.60268471
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.56960398
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.47952847
10	RNA polymerase_Homo sapiens_hsa03020	2.42701886
11	Homologous recombination_Homo sapiens_hsa03440	2.34072918
12	Protein export_Homo sapiens_hsa03060	2.29745625
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.12295908
14	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.92124895
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.90195343
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.86006628
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.82154874
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.79371563
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.73771866
20	Alzheimers disease_Homo sapiens_hsa05010	1.67927189
21	Primary immunodeficiency_Homo sapiens_hsa05340	1.65991120
22	Mismatch repair_Homo sapiens_hsa03430	1.56955274
23	One carbon pool by folate_Homo sapiens_hsa00670	1.56618590
24	Huntingtons disease_Homo sapiens_hsa05016	1.53279093
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.46285961
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.46252615
27	RNA degradation_Homo sapiens_hsa03018	1.44160884
28	Basal transcription factors_Homo sapiens_hsa03022	1.42112761
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.35183068
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.31909127
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.30048537
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.17518136
33	Chemical carcinogenesis_Homo sapiens_hsa05204	1.16429440
34	Phototransduction_Homo sapiens_hsa04744	1.16326319
35	Sulfur metabolism_Homo sapiens_hsa00920	1.13501420
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.11904937
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.11386584
38	DNA replication_Homo sapiens_hsa03030	1.10750458
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.08549477
40	Tryptophan metabolism_Homo sapiens_hsa00380	1.07755508
41	Caffeine metabolism_Homo sapiens_hsa00232	1.06771712
42	Cardiac muscle contraction_Homo sapiens_hsa04260	1.06372950
43	Propanoate metabolism_Homo sapiens_hsa00640	1.06296992
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.05162512
45	Antigen processing and presentation_Homo sapiens_hsa04612	1.00866002
46	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.00618409
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.96132806
48	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.94431311
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93582211
50	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.89461788
51	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.88263215
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.84366992
53	Spliceosome_Homo sapiens_hsa03040	0.83052578
54	Base excision repair_Homo sapiens_hsa03410	0.82558322
55	Peroxisome_Homo sapiens_hsa04146	0.82387035
56	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.81803611
57	Purine metabolism_Homo sapiens_hsa00230	0.81070626
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79659251
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.79098639
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.77096471
61	Selenocompound metabolism_Homo sapiens_hsa00450	0.76646348
62	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.74966097
63	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.74233194
64	Viral myocarditis_Homo sapiens_hsa05416	0.73525085
65	Regulation of autophagy_Homo sapiens_hsa04140	0.68797384
66	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.67568422
67	Retinol metabolism_Homo sapiens_hsa00830	0.66891931
68	RNA transport_Homo sapiens_hsa03013	0.65319530
69	Leishmaniasis_Homo sapiens_hsa05140	0.63693074
70	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.63625347
71	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.61396752
72	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.61378304
73	Non-homologous end-joining_Homo sapiens_hsa03450	0.60160121
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.59927643
75	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.54530768
76	Metabolic pathways_Homo sapiens_hsa01100	0.54020660
77	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.52606704
78	Glutathione metabolism_Homo sapiens_hsa00480	0.51756206
79	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.50473186
80	Butanoate metabolism_Homo sapiens_hsa00650	0.46667887
81	Sulfur relay system_Homo sapiens_hsa04122	0.46235408
82	Ether lipid metabolism_Homo sapiens_hsa00565	0.44729093
83	Fatty acid elongation_Homo sapiens_hsa00062	0.43711327
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.41609604
85	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.36132209
86	Olfactory transduction_Homo sapiens_hsa04740	0.35591791
87	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.35319101
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.34870241
89	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.34806173
90	Herpes simplex infection_Homo sapiens_hsa05168	0.33868014
91	Pyruvate metabolism_Homo sapiens_hsa00620	0.32819077
92	Fat digestion and absorption_Homo sapiens_hsa04975	0.31475060
93	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.31411512
94	Mineral absorption_Homo sapiens_hsa04978	0.31150689
95	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.27145667
96	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.26166266
97	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.25442307
98	Collecting duct acid secretion_Homo sapiens_hsa04966	0.25102137
99	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.24067272
100	Nicotine addiction_Homo sapiens_hsa05033	0.23323110

RPL21P107

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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