ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	6.62732893
2	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	6.14457639
3	regulation of sarcomere organization (GO:0060297)	6.08810313
4	negative regulation of protein localization to cell surface (GO:2000009)	5.83132902
5	plasma membrane repair (GO:0001778)	5.66869088
6	regulation of skeletal muscle contraction (GO:0014819)	5.26082342
7	negative regulation of nitric-oxide synthase activity (GO:0051001)	5.17478071
8	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	5.09127716
9	regulation of regulatory T cell differentiation (GO:0045589)	4.74619872
10	regulation of action potential (GO:0098900)	4.73920062
11	ribonucleoprotein complex disassembly (GO:0032988)	4.70774984
12	negative regulation of monooxygenase activity (GO:0032769)	4.63893404
13	prenylation (GO:0097354)	4.51279459
14	protein prenylation (GO:0018342)	4.51279459
15	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	4.49213923
16	positive regulation of interleukin-17 production (GO:0032740)	4.43488142
17	negative regulation of heart contraction (GO:0045822)	4.38352912
18	negative regulation of potassium ion transmembrane transport (GO:1901380)	4.37027137
19	negative regulation of muscle hypertrophy (GO:0014741)	4.35627384
20	negative regulation of organelle assembly (GO:1902116)	4.29864360
21	ATP synthesis coupled proton transport (GO:0015986)	4.24534560
22	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.24534560
23	regulation of isotype switching to IgG isotypes (GO:0048302)	4.23337072
24	membrane assembly (GO:0071709)	4.12933513
25	organelle disassembly (GO:1903008)	4.07007464
26	negative regulation of B cell apoptotic process (GO:0002903)	4.06440518
27	negative regulation of mast cell activation (GO:0033004)	3.96721065
28	water-soluble vitamin biosynthetic process (GO:0042364)	3.84933410
29	behavioral response to nicotine (GO:0035095)	3.82064884
30	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	3.82048648
31	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.79397613
32	postreplication repair (GO:0006301)	3.74618448
33	negative regulation of heart growth (GO:0061117)	3.68714370
34	negative regulation of cardiac muscle tissue growth (GO:0055022)	3.68714370
35	membrane raft organization (GO:0031579)	3.67337673
36	negative regulation of heart rate (GO:0010459)	3.54832940
37	negative regulation of cardiac muscle hypertrophy (GO:0010614)	3.45546726
38	retinal rod cell development (GO:0046548)	3.42483610
39	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.41747446
40	axoneme assembly (GO:0035082)	3.37672056
41	postsynaptic membrane organization (GO:0001941)	3.34779005
42	retinal cone cell development (GO:0046549)	3.30356952
43	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.26278942
44	base-excision repair, AP site formation (GO:0006285)	3.25090774
45	positive regulation of microtubule polymerization (GO:0031116)	3.22936753
46	protein localization to cilium (GO:0061512)	3.20779824
47	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.20007179
48	regulation of immunoglobulin secretion (GO:0051023)	3.11782623
49	S-adenosylmethionine metabolic process (GO:0046500)	3.04696899
50	regulation of membrane repolarization (GO:0060306)	3.03687047
51	rRNA catabolic process (GO:0016075)	2.98057853
52	L-fucose catabolic process (GO:0042355)	2.95128991
53	fucose catabolic process (GO:0019317)	2.95128991
54	L-fucose metabolic process (GO:0042354)	2.95128991
55	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.94394349
56	negative regulation of blood circulation (GO:1903523)	2.94281857
57	response to gravity (GO:0009629)	2.92401928
58	peptidyl-histidine modification (GO:0018202)	2.91927958
59	protein complex biogenesis (GO:0070271)	2.90603775
60	muscle cell cellular homeostasis (GO:0046716)	2.89625221
61	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.87969176
62	mitochondrial calcium ion transport (GO:0006851)	2.85920308
63	positive regulation of heart rate (GO:0010460)	2.84701153
64	regulation of alkaline phosphatase activity (GO:0010692)	2.80998495
65	pyrimidine nucleotide catabolic process (GO:0006244)	2.73927099
66	replication fork processing (GO:0031297)	2.72541934
67	respiratory chain complex IV assembly (GO:0008535)	2.70930799
68	positive regulation of cell fate commitment (GO:0010455)	2.70610968
69	positive regulation of DNA recombination (GO:0045911)	2.70376944
70	response to inactivity (GO:0014854)	2.68738664
71	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.68631889
72	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.68631889
73	NADH dehydrogenase complex assembly (GO:0010257)	2.68631889
74	response to muscle activity (GO:0014850)	2.68239130
75	positive regulation of activated T cell proliferation (GO:0042104)	2.67960647
76	negative regulation of oxidoreductase activity (GO:0051354)	2.67408014
77	rhodopsin mediated signaling pathway (GO:0016056)	2.64212130
78	negative regulation of cardiac muscle tissue development (GO:0055026)	2.64147645
79	regulation of triglyceride catabolic process (GO:0010896)	2.63435265
80	regulation of sequestering of triglyceride (GO:0010889)	2.63345764
81	mitochondrial calcium ion homeostasis (GO:0051560)	2.63131543
82	negative regulation of potassium ion transport (GO:0043267)	2.61812452
83	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.60724615
84	substrate-independent telencephalic tangential migration (GO:0021826)	2.60724615
85	mannosylation (GO:0097502)	2.58068642
86	cytochrome complex assembly (GO:0017004)	2.57674288
87	GTP biosynthetic process (GO:0006183)	2.57665105
88	cytoplasmic microtubule organization (GO:0031122)	2.56288792
89	regulation of protein localization to cell surface (GO:2000008)	2.56028128
90	mitochondrial respiratory chain complex assembly (GO:0033108)	2.53896037
91	negative regulation of JUN kinase activity (GO:0043508)	2.51388480
92	mast cell activation (GO:0045576)	2.51132648
93	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.49924315
94	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.49924315
95	positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)	2.49515879
96	positive regulation of isotype switching (GO:0045830)	2.49036283
97	termination of RNA polymerase III transcription (GO:0006386)	2.48121358
98	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.48121358
99	detection of light stimulus involved in visual perception (GO:0050908)	2.46469279
100	detection of light stimulus involved in sensory perception (GO:0050962)	2.46469279

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.82059090
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.74227441
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.68329399
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.45673749
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.38220567
6	EZH2_22144423_ChIP-Seq_EOC_Human	3.11055888
7	FUS_26573619_Chip-Seq_HEK293_Human	2.62201840
8	EWS_26573619_Chip-Seq_HEK293_Human	2.34237696
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.25209452
10	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.23955308
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.17718088
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.13111884
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.08394614
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.90566695
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.89562337
16	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.87448716
17	ELK1_19687146_ChIP-ChIP_HELA_Human	1.87383576
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.86802162
19	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.84174786
20	P300_19829295_ChIP-Seq_ESCs_Human	1.78286664
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.76443293
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.73803851
23	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68992731
24	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.67644868
25	NANOG_19829295_ChIP-Seq_ESCs_Human	1.66896018
26	SOX2_19829295_ChIP-Seq_ESCs_Human	1.66896018
27	GBX2_23144817_ChIP-Seq_PC3_Human	1.65239513
28	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.64521724
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.59255273
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.59255273
31	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.53320242
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.52896644
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51080777
34	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45712245
35	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.42973198
36	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.41114188
37	IGF1R_20145208_ChIP-Seq_DFB_Human	1.40353287
38	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39543771
39	RBPJ_21746931_ChIP-Seq_IB4_Human	1.36879301
40	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.36160872
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35488847
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35488847
43	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.35289380
44	PHF8_20622853_ChIP-Seq_HELA_Human	1.34419386
45	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.31883617
46	ETV1_20927104_ChIP-Seq_GIST48_Human	1.28069320
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.27901246
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.27829917
49	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.26729638
50	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.26247105
51	BCAT_22108803_ChIP-Seq_LS180_Human	1.24823244
52	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24181652
53	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.24174281
54	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.23905550
55	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.23505185
56	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.23400436
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23232048
58	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.22937432
59	NFYA_21822215_ChIP-Seq_K562_Human	1.22196067
60	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.22161640
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21539386
62	NCOR_22424771_ChIP-Seq_293T_Human	1.21251197
63	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21140805
64	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21140805
65	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.20957096
66	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.20889654
67	NFYB_21822215_ChIP-Seq_K562_Human	1.20274202
68	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.20225175
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18723764
70	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.18133104
71	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.17895837
72	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.17701388
73	STAT3_23295773_ChIP-Seq_U87_Human	1.16191708
74	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.15056657
75	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14611963
76	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13655785
77	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.13521739
78	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.13421607
79	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13175650
80	VDR_23849224_ChIP-Seq_CD4+_Human	1.13171916
81	CBP_21632823_ChIP-Seq_H3396_Human	1.10611170
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10298784
83	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.10167314
84	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.09968018
85	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.09946591
86	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09814663
87	TBL1_22424771_ChIP-Seq_293T_Human	1.09410844
88	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08328382
89	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.08290335
90	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.07457680
91	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.07202196
92	TCF4_23295773_ChIP-Seq_U87_Human	1.07154238
93	IRF1_19129219_ChIP-ChIP_H3396_Human	1.06807740
94	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.06407144
95	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.04703045
96	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.04302616
97	P300_18555785_Chip-Seq_ESCs_Mouse	1.04217267
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02943886
99	MYC_19829295_ChIP-Seq_ESCs_Human	1.01320419
100	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.00834239

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003950_abnormal_plasma_membrane	4.12477604
2	MP0002102_abnormal_ear_morphology	4.02626071
3	MP0001835_abnormal_antigen_presentation	3.64790946
4	MP0006292_abnormal_olfactory_placode	3.26757510
5	MP0001853_heart_inflammation	3.14836883
6	MP0006072_abnormal_retinal_apoptosis	3.09766199
7	MP0000372_irregular_coat_pigmentation	2.43139385
8	MP0003646_muscle_fatigue	2.41456692
9	MP0000749_muscle_degeneration	2.34959360
10	MP0003136_yellow_coat_color	2.11795674
11	MP0002938_white_spotting	2.05120168
12	MP0001293_anophthalmia	2.02969430
13	MP0009379_abnormal_foot_pigmentation	1.91134828
14	MP0005671_abnormal_response_to	1.90821913
15	MP0000465_gastrointestinal_hemorrhage	1.88692771
16	MP0001984_abnormal_olfaction	1.87045697
17	MP0004084_abnormal_cardiac_muscle	1.80994945
18	MP0004145_abnormal_muscle_electrophysio	1.79767139
19	MP0003300_gastrointestinal_ulcer	1.76871819
20	MP0003786_premature_aging	1.74955122
21	MP0008872_abnormal_physiological_respon	1.69480305
22	MP0005253_abnormal_eye_physiology	1.69382036
23	MP0005551_abnormal_eye_electrophysiolog	1.67982556
24	MP0001873_stomach_inflammation	1.67605637
25	MP0005171_absent_coat_pigmentation	1.61237508
26	MP0000569_abnormal_digit_pigmentation	1.60138863
27	MP0002638_abnormal_pupillary_reflex	1.57729714
28	MP0005174_abnormal_tail_pigmentation	1.57626344
29	MP0008789_abnormal_olfactory_epithelium	1.56754943
30	MP0000516_abnormal_urinary_system	1.56609839
31	MP0005367_renal/urinary_system_phenotyp	1.56609839
32	MP0002234_abnormal_pharynx_morphology	1.55106885
33	MP0004036_abnormal_muscle_relaxation	1.53173483
34	MP0008775_abnormal_heart_ventricle	1.51328475
35	MP0001502_abnormal_circadian_rhythm	1.47629809
36	MP0001485_abnormal_pinna_reflex	1.46886730
37	MP0004742_abnormal_vestibular_system	1.46566538
38	MP0001501_abnormal_sleep_pattern	1.38420485
39	MP0002837_dystrophic_cardiac_calcinosis	1.38348646
40	MP0009785_altered_susceptibility_to	1.35437579
41	MP0003567_abnormal_fetal_cardiomyocyte	1.33663081
42	MP0002095_abnormal_skin_pigmentation	1.32635121
43	MP0008875_abnormal_xenobiotic_pharmacok	1.28963988
44	MP0001486_abnormal_startle_reflex	1.28907492
45	MP0002166_altered_tumor_susceptibility	1.28756145
46	MP0003880_abnormal_central_pattern	1.26749671
47	MP0003806_abnormal_nucleotide_metabolis	1.25840075
48	MP0002006_tumorigenesis	1.16954078
49	MP0005391_vision/eye_phenotype	1.14245458
50	MP0005408_hypopigmentation	1.13060105
51	MP0000427_abnormal_hair_cycle	1.11259755
52	MP0004782_abnormal_surfactant_physiolog	1.09255155
53	MP0009764_decreased_sensitivity_to	1.07890902
54	MP0003718_maternal_effect	1.06641491
55	MP0001968_abnormal_touch/_nociception	1.03214917
56	MP0000647_abnormal_sebaceous_gland	1.03142250
57	MP0005645_abnormal_hypothalamus_physiol	1.01917072
58	MP0003186_abnormal_redox_activity	1.00630880
59	MP0005365_abnormal_bile_salt	1.00467733
60	MP0005195_abnormal_posterior_eye	0.99444921
61	MP0005187_abnormal_penis_morphology	0.98730577
62	MP0008995_early_reproductive_senescence	0.92933264
63	MP0005499_abnormal_olfactory_system	0.92840790
64	MP0005394_taste/olfaction_phenotype	0.92840790
65	MP0001440_abnormal_grooming_behavior	0.92722826
66	MP0002751_abnormal_autonomic_nervous	0.92431571
67	MP0009745_abnormal_behavioral_response	0.92306579
68	MP0001324_abnormal_eye_pigmentation	0.91111711
69	MP0002272_abnormal_nervous_system	0.91061514
70	MP0003195_calcinosis	0.90865083
71	MP0001529_abnormal_vocalization	0.89236907
72	MP0001986_abnormal_taste_sensitivity	0.88405397
73	MP0001919_abnormal_reproductive_system	0.88191439
74	MP0009046_muscle_twitch	0.86268716
75	MP0010030_abnormal_orbit_morphology	0.86210671
76	MP0000383_abnormal_hair_follicle	0.85684367
77	MP0004142_abnormal_muscle_tone	0.85023256
78	MP0004270_analgesia	0.84932297
79	MP0005389_reproductive_system_phenotype	0.83055621
80	MP0005332_abnormal_amino_acid	0.82477941
81	MP0005075_abnormal_melanosome_morpholog	0.82201901
82	MP0000751_myopathy	0.79996679
83	MP0002736_abnormal_nociception_after	0.79169822
84	MP0001800_abnormal_humoral_immune	0.78721164
85	MP0005085_abnormal_gallbladder_physiolo	0.78551386
86	MP0001970_abnormal_pain_threshold	0.78412845
87	MP0000049_abnormal_middle_ear	0.77909558
88	MP0004885_abnormal_endolymph	0.77363534
89	MP0000026_abnormal_inner_ear	0.76648707
90	MP0005379_endocrine/exocrine_gland_phen	0.74997767
91	MP0002735_abnormal_chemical_nociception	0.72318289
92	MP0002106_abnormal_muscle_physiology	0.71894775
93	MP0003878_abnormal_ear_physiology	0.70165219
94	MP0005377_hearing/vestibular/ear_phenot	0.70165219
95	MP0004381_abnormal_hair_follicle	0.69569052
96	MP0002653_abnormal_ependyma_morphology	0.69530107
97	MP0005197_abnormal_uvea_morphology	0.68897505
98	MP0002557_abnormal_social/conspecific_i	0.68277346
99	MP0002160_abnormal_reproductive_system	0.68193134
100	MP0002148_abnormal_hypersensitivity_rea	0.67061645

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the left ventricular outflow tract (HP:0011103)	5.81230290
2	Subaortic stenosis (HP:0001682)	5.81230290
3	Calf muscle hypertrophy (HP:0008981)	5.56907619
4	Muscle hypertrophy of the lower extremities (HP:0008968)	5.17355144
5	Renal cortical cysts (HP:0000803)	4.91136972
6	Exercise-induced muscle cramps (HP:0003710)	4.57426138
7	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.10869929
8	Myotonia (HP:0002486)	4.06908108
9	Abnormality of the renal cortex (HP:0011035)	3.92384552
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.38471959
11	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.22729566
12	Abnormality of alanine metabolism (HP:0010916)	3.22729566
13	Hyperalaninemia (HP:0003348)	3.22729566
14	3-Methylglutaconic aciduria (HP:0003535)	3.10176640
15	Constricted visual fields (HP:0001133)	3.03340937
16	Abolished electroretinogram (ERG) (HP:0000550)	2.99852660
17	Sudden death (HP:0001699)	2.87668123
18	Attenuation of retinal blood vessels (HP:0007843)	2.86675372
19	Exercise-induced myalgia (HP:0003738)	2.84693344
20	Bony spicule pigmentary retinopathy (HP:0007737)	2.81993674
21	Congenital stationary night blindness (HP:0007642)	2.80161716
22	Acute necrotizing encephalopathy (HP:0006965)	2.75980808
23	Increased corneal curvature (HP:0100692)	2.73183563
24	Keratoconus (HP:0000563)	2.73183563
25	Progressive macrocephaly (HP:0004481)	2.65562769
26	Hypoplasia of the thymus (HP:0000778)	2.59116397
27	Palpebral edema (HP:0100540)	2.57975181
28	Aplastic anemia (HP:0001915)	2.56664525
29	Sex reversal (HP:0012245)	2.54077898
30	Abnormal sex determination (HP:0012244)	2.54077898
31	Abnormality of the fovea (HP:0000493)	2.53753926
32	Pendular nystagmus (HP:0012043)	2.52972038
33	Methylmalonic acidemia (HP:0002912)	2.51139858
34	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.49757200
35	Hypoplasia of the fovea (HP:0007750)	2.49757200
36	Posterior subcapsular cataract (HP:0007787)	2.49188156
37	Abnormal hair whorl (HP:0010721)	2.45157880
38	Abnormal mitochondria in muscle tissue (HP:0008316)	2.44033780
39	Dyschromatopsia (HP:0007641)	2.44017151
40	Prolonged QT interval (HP:0001657)	2.43904530
41	Poor suck (HP:0002033)	2.43125962
42	Type II lissencephaly (HP:0007260)	2.41512749
43	Abnormal ciliary motility (HP:0012262)	2.41322533
44	Hepatocellular necrosis (HP:0001404)	2.36824531
45	Mitochondrial inheritance (HP:0001427)	2.32467951
46	Abnormal respiratory motile cilium morphology (HP:0005938)	2.30192478
47	Abnormal respiratory epithelium morphology (HP:0012253)	2.30192478
48	Clitoromegaly (HP:0000057)	2.28221124
49	Tubulointerstitial nephritis (HP:0001970)	2.24159519
50	Bundle branch block (HP:0011710)	2.23073908
51	Muscle stiffness (HP:0003552)	2.23033243
52	Increased CSF lactate (HP:0002490)	2.21967057
53	Asymmetric septal hypertrophy (HP:0001670)	2.19327636
54	Abnormal respiratory motile cilium physiology (HP:0012261)	2.18890424
55	Congenital, generalized hypertrichosis (HP:0004540)	2.18874226
56	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.18784029
57	Brushfield spots (HP:0001088)	2.16659543
58	Chorioretinal atrophy (HP:0000533)	2.15721016
59	Central scotoma (HP:0000603)	2.08924091
60	Congenital sensorineural hearing impairment (HP:0008527)	2.08832300
61	Type 2 muscle fiber atrophy (HP:0003554)	2.08474272
62	Acute encephalopathy (HP:0006846)	2.07707440
63	Meckel diverticulum (HP:0002245)	2.02530737
64	Increased serum pyruvate (HP:0003542)	2.00746948
65	Bronchiectasis (HP:0002110)	2.00292585
66	Cerebellar dysplasia (HP:0007033)	1.98747127
67	Aplasia/hypoplasia of the uterus (HP:0008684)	1.98377018
68	Aplasia/Hypoplasia of the macula (HP:0008059)	1.97420343
69	Vitreoretinal degeneration (HP:0000655)	1.94062054
70	Abnormality of the calf musculature (HP:0001430)	1.93122968
71	Progressive inability to walk (HP:0002505)	1.92305513
72	Abnormality of the ileum (HP:0001549)	1.91954987
73	Hepatic necrosis (HP:0002605)	1.90838009
74	Pancreatic cysts (HP:0001737)	1.90532878
75	True hermaphroditism (HP:0010459)	1.89037381
76	Stomatitis (HP:0010280)	1.88285375
77	Optic disc pallor (HP:0000543)	1.87257031
78	Hypothermia (HP:0002045)	1.86814147
79	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.85102933
80	Hypoplasia of the uterus (HP:0000013)	1.84037346
81	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.83332618
82	Methylmalonic aciduria (HP:0012120)	1.83147851
83	Rhinitis (HP:0012384)	1.83054497
84	Subcapsular cataract (HP:0000523)	1.82949974
85	Hyperlipoproteinemia (HP:0010980)	1.82757065
86	Abnormality of the renal medulla (HP:0100957)	1.80938317
87	Hypoplasia of the radius (HP:0002984)	1.80075084
88	Medial flaring of the eyebrow (HP:0010747)	1.76883496
89	Hypoproteinemia (HP:0003075)	1.75592812
90	Poor speech (HP:0002465)	1.75454803
91	Pancreatic fibrosis (HP:0100732)	1.74757523
92	Conical tooth (HP:0000698)	1.73243180
93	Increased serum lactate (HP:0002151)	1.71591116
94	Patchy hypopigmentation of hair (HP:0011365)	1.71276235
95	Increased hepatocellular lipid droplets (HP:0006565)	1.70501806
96	Hypomagnesemia (HP:0002917)	1.70395017
97	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.70299311
98	Clubbing of toes (HP:0100760)	1.68835248
99	Aplasia cutis congenita (HP:0001057)	1.68824523
100	Forearm undergrowth (HP:0009821)	1.67939593

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SCYL2	4.15569038
2	CDK19	3.98786228
3	TAOK3	3.39124692
4	NUAK1	2.98210838
5	MAPKAPK5	2.94124291
6	MAP4K2	2.86027597
7	TXK	2.57775867
8	FRK	2.53963110
9	MAP3K12	2.47298232
10	BMPR2	2.42607610
11	MUSK	2.35616615
12	FLT3	2.19043615
13	TLK1	2.14419485
14	FES	2.12315815
15	CDK8	2.05399722
16	OXSR1	2.04297533
17	MAP4K1	2.02745283
18	GRK1	1.73472203
19	PIK3CG	1.72602720
20	PLK2	1.59194874
21	WNK4	1.53643989
22	INSRR	1.43912466
23	ADRBK2	1.40067492
24	MARK3	1.39899863
25	CCNB1	1.28361796
26	EIF2AK3	1.26343317
27	MST4	1.20795630
28	TAOK1	1.18880363
29	KIT	1.17728167
30	FER	1.17229108
31	WNK3	1.16925060
32	STK39	1.09309372
33	BMPR1B	1.08734540
34	PAK6	1.04928695
35	CSNK1G2	0.98184506
36	MYLK	0.97506251
37	BUB1	0.96882412
38	DYRK2	0.90959077
39	CAMK1	0.90219388
40	MAP3K7	0.89841515
41	PIK3CA	0.89710884
42	PAK4	0.88714987
43	TEC	0.87336175
44	CASK	0.85420825
45	PINK1	0.83555668
46	ERBB3	0.83194822
47	PRKCE	0.82989249
48	IKBKB	0.81006938
49	MAPK15	0.76485707
50	VRK1	0.73566473
51	NME1	0.70496737
52	TIE1	0.69503753
53	ZAK	0.68860172
54	DAPK2	0.68592925
55	CSF1R	0.68179886
56	GRK7	0.66584502
57	OBSCN	0.65780396
58	WNK1	0.65172901
59	CSNK1G1	0.61989443
60	CSNK1G3	0.60523793
61	MAP3K14	0.58974619
62	MKNK2	0.57771411
63	CAMKK2	0.56581383
64	TAF1	0.55466191
65	CSNK1D	0.54681182
66	UHMK1	0.54239939
67	IKBKE	0.53206410
68	PRKCG	0.52978661
69	ZAP70	0.50083178
70	KDR	0.49360570
71	CHUK	0.48776969
72	CSNK1A1	0.47226973
73	PRKACB	0.46102729
74	RPS6KA5	0.45831389
75	CAMK2D	0.45678931
76	BTK	0.43931327
77	PLK3	0.40802771
78	HIPK2	0.37943301
79	TSSK6	0.37418528
80	GRK5	0.36424508
81	PRKAA2	0.36022776
82	PRKG1	0.35964643
83	ITK	0.35827347
84	LYN	0.34686465
85	RPS6KA4	0.34520479
86	CAMK2A	0.32772686
87	EPHB2	0.32137334
88	DAPK3	0.31512532
89	IGF1R	0.31255407
90	CSNK1A1L	0.30705565
91	TGFBR1	0.29836716
92	CSK	0.29650572
93	ATR	0.29422041
94	PAK3	0.29241076
95	CAMK4	0.28835251
96	WEE1	0.28681490
97	PRKCA	0.28509391
98	NTRK2	0.27502423
99	STK11	0.27305764
100	PRKACA	0.26695365

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	5.50708949
2	Allograft rejection_Homo sapiens_hsa05330	4.48580556
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	4.20140917
4	Graft-versus-host disease_Homo sapiens_hsa05332	4.19124154
5	Type I diabetes mellitus_Homo sapiens_hsa04940	3.95196387
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.77156371
7	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	3.07777855
8	Antigen processing and presentation_Homo sapiens_hsa04612	2.34455090
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.22643949
10	Viral myocarditis_Homo sapiens_hsa05416	2.19021572
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.08739019
12	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.88230047
13	Rheumatoid arthritis_Homo sapiens_hsa05323	1.80269271
14	Parkinsons disease_Homo sapiens_hsa05012	1.67528487
15	Phototransduction_Homo sapiens_hsa04744	1.65756133
16	Proteasome_Homo sapiens_hsa03050	1.54733709
17	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.53507794
18	RNA polymerase_Homo sapiens_hsa03020	1.51683944
19	One carbon pool by folate_Homo sapiens_hsa00670	1.45418844
20	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.37087818
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.34445825
22	Ribosome_Homo sapiens_hsa03010	1.32482401
23	Leishmaniasis_Homo sapiens_hsa05140	1.19491861
24	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.19005092
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.15129918
26	Protein export_Homo sapiens_hsa03060	1.14455441
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.14127434
28	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.12084754
29	Selenocompound metabolism_Homo sapiens_hsa00450	0.98747908
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.95964994
31	Alzheimers disease_Homo sapiens_hsa05010	0.92428326
32	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.92232772
33	Fanconi anemia pathway_Homo sapiens_hsa03460	0.87978448
34	Olfactory transduction_Homo sapiens_hsa04740	0.87262179
35	Primary immunodeficiency_Homo sapiens_hsa05340	0.85294433
36	Homologous recombination_Homo sapiens_hsa03440	0.84294530
37	Nicotine addiction_Homo sapiens_hsa05033	0.83472622
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.82244666
39	Tryptophan metabolism_Homo sapiens_hsa00380	0.80404983
40	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.80052511
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.78976019
42	Basal transcription factors_Homo sapiens_hsa03022	0.78787636
43	Huntingtons disease_Homo sapiens_hsa05016	0.78413881
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.77424330
45	Propanoate metabolism_Homo sapiens_hsa00640	0.77100774
46	Caffeine metabolism_Homo sapiens_hsa00232	0.71049879
47	Butanoate metabolism_Homo sapiens_hsa00650	0.70008636
48	Pyruvate metabolism_Homo sapiens_hsa00620	0.68976197
49	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.67915348
50	Lysine degradation_Homo sapiens_hsa00310	0.67360190
51	Peroxisome_Homo sapiens_hsa04146	0.65487897
52	Linoleic acid metabolism_Homo sapiens_hsa00591	0.64306742
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.63242490
54	Herpes simplex infection_Homo sapiens_hsa05168	0.62485768
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61721677
56	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.61629998
57	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.59923346
58	Toxoplasmosis_Homo sapiens_hsa05145	0.59564818
59	Circadian rhythm_Homo sapiens_hsa04710	0.57146548
60	RNA degradation_Homo sapiens_hsa03018	0.55328925
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.54835930
62	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.52978143
63	ABC transporters_Homo sapiens_hsa02010	0.51963134
64	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.51893619
65	Phagosome_Homo sapiens_hsa04145	0.51231448
66	Pyrimidine metabolism_Homo sapiens_hsa00240	0.50078700
67	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.49372147
68	Fatty acid degradation_Homo sapiens_hsa00071	0.48897601
69	Salivary secretion_Homo sapiens_hsa04970	0.48800769
70	Taste transduction_Homo sapiens_hsa04742	0.48642485
71	Histidine metabolism_Homo sapiens_hsa00340	0.48496939
72	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.46626578
73	Tuberculosis_Homo sapiens_hsa05152	0.41458403
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40808378
75	GABAergic synapse_Homo sapiens_hsa04727	0.38141458
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.37016766
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36490411
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.34962308
79	Chemical carcinogenesis_Homo sapiens_hsa05204	0.34427470
80	Regulation of autophagy_Homo sapiens_hsa04140	0.32270182
81	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.31954840
82	Morphine addiction_Homo sapiens_hsa05032	0.30633697
83	Influenza A_Homo sapiens_hsa05164	0.28463468
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.27751014
85	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.25950751
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.25278559
87	Serotonergic synapse_Homo sapiens_hsa04726	0.24263573
88	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.23560773
89	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.22730147
90	Non-homologous end-joining_Homo sapiens_hsa03450	0.22696139
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.22631909
92	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.21961230
93	Mineral absorption_Homo sapiens_hsa04978	0.21842919
94	RNA transport_Homo sapiens_hsa03013	0.21365575
95	Ether lipid metabolism_Homo sapiens_hsa00565	0.21297411
96	Retinol metabolism_Homo sapiens_hsa00830	0.21148873
97	Pancreatic secretion_Homo sapiens_hsa04972	0.20838222
98	Legionellosis_Homo sapiens_hsa05134	0.20224434
99	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.20018412
100	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.19894122

RPL21P109

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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