RPL21P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)5.87998472
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.87998472
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.70903121
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.11916582
5ribosomal small subunit assembly (GO:0000028)5.08532451
6protein complex biogenesis (GO:0070271)4.93458594
7DNA deamination (GO:0045006)4.84886729
8protein neddylation (GO:0045116)4.72376602
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.62005007
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.62005007
11NADH dehydrogenase complex assembly (GO:0010257)4.62005007
12respiratory electron transport chain (GO:0022904)4.60893729
13electron transport chain (GO:0022900)4.57956831
14viral transcription (GO:0019083)4.47894141
15mitochondrial respiratory chain complex assembly (GO:0033108)4.41982801
16translational termination (GO:0006415)4.39398338
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.30753522
18cotranslational protein targeting to membrane (GO:0006613)4.26527127
19protein targeting to ER (GO:0045047)4.23015202
20water-soluble vitamin biosynthetic process (GO:0042364)4.15284379
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.06816416
22protein localization to endoplasmic reticulum (GO:0070972)4.04185064
23behavioral response to nicotine (GO:0035095)4.02443874
24translational elongation (GO:0006414)3.87198086
25chaperone-mediated protein transport (GO:0072321)3.84851009
26establishment of protein localization to mitochondrial membrane (GO:0090151)3.79325070
27respiratory chain complex IV assembly (GO:0008535)3.76351215
28platelet dense granule organization (GO:0060155)3.70773204
29ribosomal large subunit biogenesis (GO:0042273)3.59810206
30termination of RNA polymerase III transcription (GO:0006386)3.58851591
31transcription elongation from RNA polymerase III promoter (GO:0006385)3.58851591
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.55410052
33hydrogen ion transmembrane transport (GO:1902600)3.51496347
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.49846894
35cytochrome complex assembly (GO:0017004)3.47230920
36proton transport (GO:0015992)3.35965076
37translation (GO:0006412)3.35227426
38maturation of SSU-rRNA (GO:0030490)3.31456966
39ribosomal small subunit biogenesis (GO:0042274)3.29815940
40hydrogen transport (GO:0006818)3.29594093
41purine nucleoside triphosphate biosynthetic process (GO:0009145)3.26118051
42GTP biosynthetic process (GO:0006183)3.24963134
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.24130068
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.24130068
45viral life cycle (GO:0019058)3.23755652
46cellular protein complex disassembly (GO:0043624)3.23367366
47purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.23363053
48ATP biosynthetic process (GO:0006754)3.22857764
49proteasome assembly (GO:0043248)3.07378211
50translational initiation (GO:0006413)3.04184247
51regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.02210811
52positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.99355008
53protein-cofactor linkage (GO:0018065)2.98459701
54response to pheromone (GO:0019236)2.98397345
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.97087966
56negative regulation of mast cell activation (GO:0033004)2.93924317
57regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.91088490
58cellular component biogenesis (GO:0044085)2.90636013
59cytidine metabolic process (GO:0046087)2.88613093
60cytidine catabolic process (GO:0006216)2.88613093
61cytidine deamination (GO:0009972)2.88613093
62organelle disassembly (GO:1903008)2.86384946
63epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.80902706
64axoneme assembly (GO:0035082)2.80081203
65regulation of cellular amino acid metabolic process (GO:0006521)2.78749472
66signal peptide processing (GO:0006465)2.78400199
67positive regulation of respiratory burst (GO:0060267)2.74296829
68protein targeting to membrane (GO:0006612)2.72496310
69intracellular protein transmembrane import (GO:0044743)2.71121478
70ribonucleoside triphosphate biosynthetic process (GO:0009201)2.68647802
71regulation of glucokinase activity (GO:0033131)2.68445058
72regulation of hexokinase activity (GO:1903299)2.68445058
73regulation of chronic inflammatory response (GO:0002676)2.68371302
74sequestering of actin monomers (GO:0042989)2.68167845
75kynurenine metabolic process (GO:0070189)2.67907690
76base-excision repair, AP site formation (GO:0006285)2.62716837
77tryptophan catabolic process (GO:0006569)2.61204528
78indole-containing compound catabolic process (GO:0042436)2.61204528
79indolalkylamine catabolic process (GO:0046218)2.61204528
80mannosylation (GO:0097502)2.60539592
81auditory receptor cell differentiation (GO:0042491)2.59876143
82spinal cord association neuron differentiation (GO:0021527)2.59705998
83negative regulation of heart rate (GO:0010459)2.58670466
84DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.57594588
85negative regulation of telomere maintenance (GO:0032205)2.57282483
86protein complex disassembly (GO:0043241)2.56990586
87protein peptidyl-prolyl isomerization (GO:0000413)2.56625314
88macromolecular complex disassembly (GO:0032984)2.56234513
89epithelial cilium movement (GO:0003351)2.54765960
90tRNA processing (GO:0008033)2.54166485
91aldehyde catabolic process (GO:0046185)2.53229319
92regulation of isotype switching to IgG isotypes (GO:0048302)2.50226934
93nonmotile primary cilium assembly (GO:0035058)2.49914050
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.49184697
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.49184697
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.49184697
97rRNA processing (GO:0006364)2.49054282
98UTP biosynthetic process (GO:0006228)2.48379760
99rRNA metabolic process (GO:0016072)2.48260535
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.46886287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.97101563
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.51130230
3VDR_22108803_ChIP-Seq_LS180_Human3.33001245
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.23778338
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.22704815
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06915369
7ZNF274_21170338_ChIP-Seq_K562_Hela2.90868398
8EZH2_22144423_ChIP-Seq_EOC_Human2.67688447
9IGF1R_20145208_ChIP-Seq_DFB_Human2.42156223
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.30297147
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24414465
12VDR_23849224_ChIP-Seq_CD4+_Human2.13280851
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09361137
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.00666222
15EWS_26573619_Chip-Seq_HEK293_Human1.97773974
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91007627
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88982319
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88854454
19ELK1_19687146_ChIP-ChIP_HELA_Human1.85135289
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73060528
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69369433
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67473978
23MYC_18940864_ChIP-ChIP_HL60_Human1.64956831
24FOXP3_21729870_ChIP-Seq_TREG_Human1.64520162
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64462208
26TP53_22573176_ChIP-Seq_HFKS_Human1.63974543
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62261670
28GBX2_23144817_ChIP-Seq_PC3_Human1.61151095
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58941989
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56692427
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54826799
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51135971
33ER_23166858_ChIP-Seq_MCF-7_Human1.50024469
34P300_19829295_ChIP-Seq_ESCs_Human1.49431085
35FUS_26573619_Chip-Seq_HEK293_Human1.46508303
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46178745
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45695486
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.45064534
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45033631
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.42743100
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38462221
42TAF15_26573619_Chip-Seq_HEK293_Human1.37535393
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36474512
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35945029
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35912765
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33985609
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.33985609
48IRF1_19129219_ChIP-ChIP_H3396_Human1.30711685
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29162728
50AR_20517297_ChIP-Seq_VCAP_Human1.28121916
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26426886
52CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.25904121
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25855669
54SOX2_19829295_ChIP-Seq_ESCs_Human1.23829339
55NANOG_19829295_ChIP-Seq_ESCs_Human1.23829339
56NCOR_22424771_ChIP-Seq_293T_Human1.23525385
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18719498
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18689694
59CBP_20019798_ChIP-Seq_JUKART_Human1.18689694
60NANOG_20526341_ChIP-Seq_ESCs_Human1.17466414
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16458113
62HTT_18923047_ChIP-ChIP_STHdh_Human1.14047383
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11684071
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.11105209
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10638934
66MYC_18555785_ChIP-Seq_MESCs_Mouse1.09757195
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09171787
68MYC_19829295_ChIP-Seq_ESCs_Human1.07746940
69FOXH1_21741376_ChIP-Seq_EPCs_Human1.07550224
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.07022778
71TAF2_19829295_ChIP-Seq_ESCs_Human1.06050415
72BCAT_22108803_ChIP-Seq_LS180_Human1.05607274
73TTF2_22483619_ChIP-Seq_HELA_Human1.05240747
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.05112561
75ERG_20517297_ChIP-Seq_VCAP_Human1.02990270
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02985702
77TCF4_22108803_ChIP-Seq_LS180_Human1.01546204
78HOXB7_26014856_ChIP-Seq_BT474_Human1.00950158
79EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00916047
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00207394
81GATA3_26560356_Chip-Seq_TH2_Human1.00138485
82YY1_21170310_ChIP-Seq_MESCs_Mouse0.99008016
83REST_21632747_ChIP-Seq_MESCs_Mouse0.98440314
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98345967
85ELK1_22589737_ChIP-Seq_MCF10A_Human0.98101522
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96377180
87ERA_21632823_ChIP-Seq_H3396_Human0.96227360
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95723193
89RNF2_27304074_Chip-Seq_NSC_Mouse0.94870073
90PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94839945
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94273259
92TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93276603
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91543676
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90704330
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90126310
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89844232
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.89803655
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88147388
99MYC_18358816_ChIP-ChIP_MESCs_Mouse0.87469084
100TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87195040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.68782866
2MP0002102_abnormal_ear_morphology3.05905429
3MP0003787_abnormal_imprinting2.94189116
4MP0006072_abnormal_retinal_apoptosis2.57724211
5MP0002837_dystrophic_cardiac_calcinosis2.56624980
6MP0008877_abnormal_DNA_methylation2.52182515
7MP0003123_paternal_imprinting2.49083886
8MP0006292_abnormal_olfactory_placode2.43764921
9MP0008872_abnormal_physiological_respon2.43026273
10MP0001986_abnormal_taste_sensitivity2.18745323
11MP0002163_abnormal_gland_morphology2.16923504
12MP0004142_abnormal_muscle_tone2.10156982
13MP0001485_abnormal_pinna_reflex2.05346279
14MP0003880_abnormal_central_pattern2.03157568
15MP0005645_abnormal_hypothalamus_physiol1.99417819
16MP0005551_abnormal_eye_electrophysiolog1.97424870
17MP0005671_abnormal_response_to1.96384125
18MP0004885_abnormal_endolymph1.96114077
19MP0003646_muscle_fatigue1.94063599
20MP0002638_abnormal_pupillary_reflex1.93896178
21MP0001835_abnormal_antigen_presentation1.81842751
22MP0005646_abnormal_pituitary_gland1.78773716
23MP0008875_abnormal_xenobiotic_pharmacok1.73367311
24MP0005379_endocrine/exocrine_gland_phen1.68794636
25MP0001968_abnormal_touch/_nociception1.68363632
26MP0003195_calcinosis1.64096578
27MP0008789_abnormal_olfactory_epithelium1.61146418
28MP0001529_abnormal_vocalization1.56337983
29MP0002876_abnormal_thyroid_physiology1.53329849
30MP0000372_irregular_coat_pigmentation1.50939678
31MP0003122_maternal_imprinting1.49046341
32MP0003806_abnormal_nucleotide_metabolis1.46975498
33MP0000631_abnormal_neuroendocrine_gland1.46956983
34MP0001905_abnormal_dopamine_level1.43288870
35MP0003121_genomic_imprinting1.42976896
36MP0002272_abnormal_nervous_system1.42641044
37MP0004147_increased_porphyrin_level1.41766210
38MP0004742_abnormal_vestibular_system1.41281262
39MP0001984_abnormal_olfaction1.41268653
40MP0005253_abnormal_eye_physiology1.39012032
41MP0004145_abnormal_muscle_electrophysio1.36333115
42MP0003011_delayed_dark_adaptation1.33093148
43MP0001348_abnormal_lacrimal_gland1.31476287
44MP0006276_abnormal_autonomic_nervous1.28930392
45MP0009745_abnormal_behavioral_response1.27357892
46MP0005377_hearing/vestibular/ear_phenot1.27018720
47MP0003878_abnormal_ear_physiology1.27018720
48MP0001919_abnormal_reproductive_system1.25940474
49MP0000685_abnormal_immune_system1.22228348
50MP0005389_reproductive_system_phenotype1.21235456
51MP0002138_abnormal_hepatobiliary_system1.20902260
52MP0009046_muscle_twitch1.20241248
53MP0001970_abnormal_pain_threshold1.15543161
54MP0005499_abnormal_olfactory_system1.14018548
55MP0005394_taste/olfaction_phenotype1.14018548
56MP0002736_abnormal_nociception_after1.13373516
57MP0001440_abnormal_grooming_behavior1.10369074
58MP0002938_white_spotting1.09182233
59MP0003186_abnormal_redox_activity1.08224047
60MP0006036_abnormal_mitochondrial_physio1.07258938
61MP0001873_stomach_inflammation1.07053725
62MP0001486_abnormal_startle_reflex1.04839214
63MP0002557_abnormal_social/conspecific_i1.04497974
64MP0002693_abnormal_pancreas_physiology1.01518658
65MP0002234_abnormal_pharynx_morphology0.99968634
66MP0005084_abnormal_gallbladder_morpholo0.97864537
67MP0004133_heterotaxia0.97541938
68MP0005075_abnormal_melanosome_morpholog0.97302216
69MP0001293_anophthalmia0.97197727
70MP0005423_abnormal_somatic_nervous0.96082650
71MP0002160_abnormal_reproductive_system0.96006663
72MP0010386_abnormal_urinary_bladder0.95646857
73MP0005636_abnormal_mineral_homeostasis0.94588588
74MP0002735_abnormal_chemical_nociception0.94349319
75MP0002734_abnormal_mechanical_nocicepti0.93806717
76MP0008058_abnormal_DNA_repair0.92640635
77MP0005195_abnormal_posterior_eye0.92463215
78MP0008995_early_reproductive_senescence0.92125082
79MP0002733_abnormal_thermal_nociception0.91691464
80MP0003786_premature_aging0.90880791
81MP0002572_abnormal_emotion/affect_behav0.90746253
82MP0002653_abnormal_ependyma_morphology0.89622559
83MP0003718_maternal_effect0.88506856
84MP0009764_decreased_sensitivity_to0.88481620
85MP0000639_abnormal_adrenal_gland0.87690227
86MP0001764_abnormal_homeostasis0.86718900
87MP0000427_abnormal_hair_cycle0.85744543
88MP0002095_abnormal_skin_pigmentation0.84704279
89MP0001963_abnormal_hearing_physiology0.84588884
90MP0002067_abnormal_sensory_capabilities0.84378700
91MP0009785_altered_susceptibility_to0.81171472
92MP0002277_abnormal_respiratory_mucosa0.78388388
93MP0001790_abnormal_immune_system0.78108153
94MP0005387_immune_system_phenotype0.78108153
95MP0000049_abnormal_middle_ear0.77707767
96MP0001501_abnormal_sleep_pattern0.76219856
97MP0002752_abnormal_somatic_nervous0.75890838
98MP0002184_abnormal_innervation0.74876970
99MP0003283_abnormal_digestive_organ0.74730323
100MP0004924_abnormal_behavior0.73938078

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.35384046
2Abnormal mitochondria in muscle tissue (HP:0008316)4.70951455
3Mitochondrial inheritance (HP:0001427)4.65772375
4Acute encephalopathy (HP:0006846)4.58961928
5Progressive macrocephaly (HP:0004481)4.53287787
6Increased CSF lactate (HP:0002490)4.08959322
7Hepatocellular necrosis (HP:0001404)3.94404516
8Increased hepatocellular lipid droplets (HP:0006565)3.82301136
9Congenital stationary night blindness (HP:0007642)3.69966116
10Lipid accumulation in hepatocytes (HP:0006561)3.64298509
11Hepatic necrosis (HP:0002605)3.63568887
12Abnormality of midbrain morphology (HP:0002418)3.55169416
13Molar tooth sign on MRI (HP:0002419)3.55169416
14Septo-optic dysplasia (HP:0100842)3.45031334
15Cerebral edema (HP:0002181)3.26444734
16Pancreatic cysts (HP:0001737)3.22482356
17Renal Fanconi syndrome (HP:0001994)3.02640758
18Pancreatic fibrosis (HP:0100732)3.02249760
19Reticulocytopenia (HP:0001896)3.00995523
20Optic disc pallor (HP:0000543)2.95225744
213-Methylglutaconic aciduria (HP:0003535)2.91931536
22Methylmalonic acidemia (HP:0002912)2.82079440
23Increased serum lactate (HP:0002151)2.78118169
24Abnormal rod and cone electroretinograms (HP:0008323)2.74797793
25Abnormality of cells of the erythroid lineage (HP:0012130)2.72215907
26Abnormality of the renal cortex (HP:0011035)2.71741648
27Nephronophthisis (HP:0000090)2.67402478
28Congenital, generalized hypertrichosis (HP:0004540)2.66210932
29Medial flaring of the eyebrow (HP:0010747)2.66115899
30Increased intramyocellular lipid droplets (HP:0012240)2.64937557
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.62924971
32Type II lissencephaly (HP:0007260)2.57981225
33True hermaphroditism (HP:0010459)2.57683195
34Methylmalonic aciduria (HP:0012120)2.48410578
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44148339
36Exertional dyspnea (HP:0002875)2.43736854
37Respiratory failure (HP:0002878)2.42749221
38Leukodystrophy (HP:0002415)2.40176526
39Stomatitis (HP:0010280)2.36749937
40Macrocytic anemia (HP:0001972)2.35870399
41Pendular nystagmus (HP:0012043)2.35454837
42Lactic acidosis (HP:0003128)2.34771103
43Renal cortical cysts (HP:0000803)2.32745882
44Abnormality of the renal medulla (HP:0100957)2.32714807
45Abolished electroretinogram (ERG) (HP:0000550)2.30129470
46IgG deficiency (HP:0004315)2.30051116
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.29610912
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.29610912
49Increased muscle lipid content (HP:0009058)2.24707646
50Lethargy (HP:0001254)2.23808030
51Optic nerve hypoplasia (HP:0000609)2.20758211
52Colon cancer (HP:0003003)2.20380976
53Abnormal number of erythroid precursors (HP:0012131)2.16978146
54Exercise intolerance (HP:0003546)2.15349675
55Glycosuria (HP:0003076)2.12741028
56Abnormality of urine glucose concentration (HP:0011016)2.12741028
57Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10674428
58Aplasia/Hypoplasia of the spleen (HP:0010451)2.09053944
59Asplenia (HP:0001746)2.06010004
60Hypoproteinemia (HP:0003075)2.05719706
61Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00494900
62Absent thumb (HP:0009777)1.98002855
63Gait imbalance (HP:0002141)1.97418871
64Abnormality of renal resorption (HP:0011038)1.96609627
65Sclerocornea (HP:0000647)1.96162194
66Abnormal drinking behavior (HP:0030082)1.95632075
67Polydipsia (HP:0001959)1.95632075
68Aplastic anemia (HP:0001915)1.94742744
69Congenital primary aphakia (HP:0007707)1.94214622
70Aplasia/hypoplasia of the uterus (HP:0008684)1.93098937
71Attenuation of retinal blood vessels (HP:0007843)1.89041044
72Hypomagnesemia (HP:0002917)1.88152066
73Absent septum pellucidum (HP:0001331)1.87505980
74Hyperphosphaturia (HP:0003109)1.85685499
75Growth hormone deficiency (HP:0000824)1.85642389
76Chronic hepatic failure (HP:0100626)1.85047075
77Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84886617
78Hypoalbuminemia (HP:0003073)1.84329799
79Abnormal albumin level (HP:0012116)1.84329799
80Male pseudohermaphroditism (HP:0000037)1.82897061
81Ketoacidosis (HP:0001993)1.82460496
82Constricted visual fields (HP:0001133)1.81080121
83Agitation (HP:0000713)1.80445244
84Cystic liver disease (HP:0006706)1.80312138
85Hyperglycinemia (HP:0002154)1.80306855
86CNS demyelination (HP:0007305)1.79247910
87Abnormality of magnesium homeostasis (HP:0004921)1.76816816
88Abnormality of vitamin B metabolism (HP:0004340)1.76745742
89Tubular atrophy (HP:0000092)1.76358092
90X-linked dominant inheritance (HP:0001423)1.75533921
91Polyuria (HP:0000103)1.74390323
92Abnormality of the labia minora (HP:0012880)1.74213121
93Abnormal respiratory epithelium morphology (HP:0012253)1.74072677
94Abnormal respiratory motile cilium morphology (HP:0005938)1.74072677
95Ketosis (HP:0001946)1.73337950
96Keratoconus (HP:0000563)1.72623148
97Increased corneal curvature (HP:0100692)1.72623148
98Supernumerary spleens (HP:0009799)1.72059797
99Decreased central vision (HP:0007663)1.71149988
100Elevated erythrocyte sedimentation rate (HP:0003565)1.71092887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK2.89380802
2GRK12.78913505
3ADRBK22.75284451
4ZAK2.55457549
5TXK2.38481455
6MAP4K22.37303907
7VRK22.36380521
8STK162.28722866
9PINK12.23064236
10MAP3K122.19670002
11WNK42.13778761
12TRIM282.04941299
13NUAK11.99249474
14MST41.85019287
15PASK1.81916011
16TLK11.79462743
17WNK31.79192554
18CDK191.77625618
19NME11.66320713
20BMPR1B1.66208617
21BCKDK1.65374138
22DYRK21.58338877
23TIE11.56457816
24EIF2AK31.52490724
25OXSR11.52330010
26STK391.47810609
27EIF2AK11.44050558
28TEC1.42734292
29PAK31.34277157
30INSRR1.29684398
31VRK11.29472512
32MAP4K11.26116123
33TAOK31.25410998
34MYLK1.20250398
35ITK1.18944966
36CSNK1G31.17902980
37KDR1.16816775
38CSNK1G21.12376857
39TNIK1.03314783
40CSNK1G11.00241391
41TNK20.99764640
42PIK3CA0.91777444
43PHKG10.91530357
44PHKG20.91530357
45CAMKK20.86458826
46MUSK0.86108958
47PLK20.86050399
48MAP3K40.82348321
49ADRBK10.82088884
50LIMK10.80289932
51MAPK130.79555753
52FES0.79347125
53PRKCE0.79102458
54CSNK1A1L0.77324322
55PRKCG0.75910183
56PLK30.75272941
57CASK0.73075329
58PRKCQ0.71810765
59TESK20.69633396
60MKNK20.69543685
61PLK40.68860316
62MAP2K70.66475083
63SRPK10.64910459
64IKBKB0.63745904
65LRRK20.63221965
66STK38L0.63131807
67CAMKK10.62166496
68MAP2K60.61115683
69NEK10.60448014
70CDK80.60183848
71PRKACA0.59398769
72SYK0.59212715
73OBSCN0.53856405
74MAP3K110.53363718
75TGFBR10.51899348
76CSNK2A20.50903102
77BTK0.49810986
78CSNK1A10.49476227
79DAPK10.49053277
80CAMK10.47458553
81PRKCA0.47363138
82TSSK60.46930828
83DAPK20.46929853
84LYN0.45938149
85GRK60.45430241
86RPS6KA50.45401938
87DAPK30.43415136
88CDC70.43111067
89CAMK2A0.42855366
90CSNK2A10.42164033
91PLK10.41909736
92PDK20.41258408
93BCR0.40832325
94GRK70.39116179
95PRKG10.38088456
96ERBB30.37802676
97ILK0.36055386
98PKN10.33982504
99ACVR1B0.33840343
100CAMK2D0.32835265

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.43796599
2Ribosome_Homo sapiens_hsa030103.98565027
3Parkinsons disease_Homo sapiens_hsa050123.49665004
4Protein export_Homo sapiens_hsa030603.37923162
5Proteasome_Homo sapiens_hsa030503.32815712
6Alzheimers disease_Homo sapiens_hsa050102.42041198
7Asthma_Homo sapiens_hsa053102.40701432
8Huntingtons disease_Homo sapiens_hsa050162.27420634
9RNA polymerase_Homo sapiens_hsa030202.25265440
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18103783
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.15858425
12Cardiac muscle contraction_Homo sapiens_hsa042602.09781332
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.91788494
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83767092
15Allograft rejection_Homo sapiens_hsa053301.82750548
16Type I diabetes mellitus_Homo sapiens_hsa049401.74525187
17Autoimmune thyroid disease_Homo sapiens_hsa053201.71448590
18Primary immunodeficiency_Homo sapiens_hsa053401.66233420
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.61618578
20Phototransduction_Homo sapiens_hsa047441.57410731
21Homologous recombination_Homo sapiens_hsa034401.56588508
22Regulation of autophagy_Homo sapiens_hsa041401.45150601
23Linoleic acid metabolism_Homo sapiens_hsa005911.37467029
24Graft-versus-host disease_Homo sapiens_hsa053321.34944445
25RNA degradation_Homo sapiens_hsa030181.33859702
26Basal transcription factors_Homo sapiens_hsa030221.33053045
27Butanoate metabolism_Homo sapiens_hsa006501.29070732
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28292429
29Propanoate metabolism_Homo sapiens_hsa006401.24020923
30Caffeine metabolism_Homo sapiens_hsa002321.22414275
31Mismatch repair_Homo sapiens_hsa034301.22222359
32Collecting duct acid secretion_Homo sapiens_hsa049661.21894102
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19071410
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11509709
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03148523
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02707398
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02072076
38Tryptophan metabolism_Homo sapiens_hsa003801.01089090
39Steroid biosynthesis_Homo sapiens_hsa001001.01036583
40Folate biosynthesis_Homo sapiens_hsa007901.00084450
41Pyrimidine metabolism_Homo sapiens_hsa002400.96969383
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96308413
43One carbon pool by folate_Homo sapiens_hsa006700.92845278
44Rheumatoid arthritis_Homo sapiens_hsa053230.92455396
45Nitrogen metabolism_Homo sapiens_hsa009100.92177442
46Antigen processing and presentation_Homo sapiens_hsa046120.90705549
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88368287
48Peroxisome_Homo sapiens_hsa041460.87803406
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87767411
50Fanconi anemia pathway_Homo sapiens_hsa034600.86778446
51Purine metabolism_Homo sapiens_hsa002300.85211295
52Nicotine addiction_Homo sapiens_hsa050330.85050442
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83349576
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83127807
55Chemical carcinogenesis_Homo sapiens_hsa052040.82643489
56Nucleotide excision repair_Homo sapiens_hsa034200.79556492
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.78542793
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75095184
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71725175
60Sulfur metabolism_Homo sapiens_hsa009200.69727732
61Retinol metabolism_Homo sapiens_hsa008300.68855823
62Hematopoietic cell lineage_Homo sapiens_hsa046400.68456711
63Metabolic pathways_Homo sapiens_hsa011000.65509387
64Olfactory transduction_Homo sapiens_hsa047400.62568011
65Pyruvate metabolism_Homo sapiens_hsa006200.60905115
66Fat digestion and absorption_Homo sapiens_hsa049750.60656923
67Insulin secretion_Homo sapiens_hsa049110.60459499
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60067618
69Arachidonic acid metabolism_Homo sapiens_hsa005900.59129045
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58289240
71Ether lipid metabolism_Homo sapiens_hsa005650.57514122
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54664290
73RNA transport_Homo sapiens_hsa030130.53326295
74Morphine addiction_Homo sapiens_hsa050320.50878366
75Ovarian steroidogenesis_Homo sapiens_hsa049130.50156253
76Base excision repair_Homo sapiens_hsa034100.48311525
77DNA replication_Homo sapiens_hsa030300.47883948
78Spliceosome_Homo sapiens_hsa030400.47446906
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44699622
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44624355
81Selenocompound metabolism_Homo sapiens_hsa004500.42444265
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.41775901
83GABAergic synapse_Homo sapiens_hsa047270.37596607
84Sulfur relay system_Homo sapiens_hsa041220.37568533
85Vitamin B6 metabolism_Homo sapiens_hsa007500.37204264
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37137135
87Mineral absorption_Homo sapiens_hsa049780.37120053
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35946567
89Taste transduction_Homo sapiens_hsa047420.35704026
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35422265
91Fatty acid degradation_Homo sapiens_hsa000710.35204954
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34652320
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.34423273
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33946191
95Serotonergic synapse_Homo sapiens_hsa047260.32378882
96Non-homologous end-joining_Homo sapiens_hsa034500.31992283
97Glutathione metabolism_Homo sapiens_hsa004800.31075068
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28690096
99Glutamatergic synapse_Homo sapiens_hsa047240.28153285
100Fatty acid elongation_Homo sapiens_hsa000620.27608069

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