RPL21P110

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of isotype switching to IgG isotypes (GO:0048302)5.61287470
2behavioral response to nicotine (GO:0035095)4.98714187
3ribosomal small subunit assembly (GO:0000028)4.98343245
4positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.86977646
5ATP synthesis coupled proton transport (GO:0015986)4.81245371
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.81245371
7regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.55028575
8viral transcription (GO:0019083)4.48370692
9translational termination (GO:0006415)4.32669639
10regulation of immunoglobulin secretion (GO:0051023)4.14171449
11regulation of regulatory T cell differentiation (GO:0045589)4.07199736
12ribosomal small subunit biogenesis (GO:0042274)4.00334169
13interferon-gamma production (GO:0032609)3.89082303
14DNA deamination (GO:0045006)3.84355086
15protein neddylation (GO:0045116)3.81383420
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.80419349
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.79401505
18cotranslational protein targeting to membrane (GO:0006613)3.76609703
19protein targeting to ER (GO:0045047)3.74265622
20GTP biosynthetic process (GO:0006183)3.70978537
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.70939597
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.70939597
23NADH dehydrogenase complex assembly (GO:0010257)3.70939597
24translational elongation (GO:0006414)3.63976599
25protein localization to endoplasmic reticulum (GO:0070972)3.59532961
26fucose catabolic process (GO:0019317)3.58966160
27L-fucose metabolic process (GO:0042354)3.58966160
28L-fucose catabolic process (GO:0042355)3.58966160
29establishment of protein localization to endoplasmic reticulum (GO:0072599)3.55170627
30positive regulation of defense response to virus by host (GO:0002230)3.52898512
31positive regulation of isotype switching (GO:0045830)3.46986961
32positive regulation of DNA recombination (GO:0045911)3.39198371
33chaperone-mediated protein transport (GO:0072321)3.37219556
34water-soluble vitamin biosynthetic process (GO:0042364)3.35774240
35ribosomal large subunit biogenesis (GO:0042273)3.34348868
36maturation of SSU-rRNA (GO:0030490)3.30354187
37viral life cycle (GO:0019058)3.20823517
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.20320898
39protein complex biogenesis (GO:0070271)3.18298322
40RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18214892
41tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18214892
42cellular response to exogenous dsRNA (GO:0071360)3.12915243
43cellular response to interleukin-15 (GO:0071350)3.11659395
44positive regulation of fatty acid transport (GO:2000193)3.09494958
45cellular protein complex disassembly (GO:0043624)3.08454142
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.08259498
47pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.02579080
48auditory receptor cell differentiation (GO:0042491)3.00983441
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.00529563
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00067874
51regulation of B cell receptor signaling pathway (GO:0050855)2.98373009
52hydrogen ion transmembrane transport (GO:1902600)2.96950393
53UTP biosynthetic process (GO:0006228)2.96507402
54piRNA metabolic process (GO:0034587)2.93017540
55respiratory electron transport chain (GO:0022904)2.90672020
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.90024573
57termination of RNA polymerase III transcription (GO:0006386)2.89557501
58transcription elongation from RNA polymerase III promoter (GO:0006385)2.89557501
59electron transport chain (GO:0022900)2.89183661
60mitochondrial calcium ion transport (GO:0006851)2.88872931
61purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.87050763
62positive regulation of prostaglandin secretion (GO:0032308)2.86277626
63proton transport (GO:0015992)2.85843077
64positive regulation of interleukin-17 production (GO:0032740)2.85825295
65purine nucleoside triphosphate biosynthetic process (GO:0009145)2.83292984
66base-excision repair, AP site formation (GO:0006285)2.82688468
67substrate-independent telencephalic tangential migration (GO:0021826)2.81383272
68substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.81383272
69positive regulation of cell fate commitment (GO:0010455)2.80667925
70positive regulation of respiratory burst (GO:0060267)2.79736194
71translation (GO:0006412)2.79328249
72pyrimidine nucleotide catabolic process (GO:0006244)2.79106565
73mitochondrial respiratory chain complex assembly (GO:0033108)2.77605812
74DNA methylation involved in gamete generation (GO:0043046)2.77285755
75positive regulation of activated T cell proliferation (GO:0042104)2.76611808
76hydrogen transport (GO:0006818)2.76405245
77translational initiation (GO:0006413)2.71930656
78epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64839782
79negative regulation of mast cell activation (GO:0033004)2.63000097
80indolalkylamine metabolic process (GO:0006586)2.62993292
81endoderm formation (GO:0001706)2.62685393
82detection of light stimulus involved in visual perception (GO:0050908)2.61706067
83detection of light stimulus involved in sensory perception (GO:0050962)2.61706067
84ATP biosynthetic process (GO:0006754)2.60547255
85positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.60455686
86rRNA catabolic process (GO:0016075)2.58998738
87drug catabolic process (GO:0042737)2.58970316
88cellular component biogenesis (GO:0044085)2.58366772
89UTP metabolic process (GO:0046051)2.56323384
90positive regulation of B cell mediated immunity (GO:0002714)2.55197734
91positive regulation of immunoglobulin mediated immune response (GO:0002891)2.55197734
92ribonucleoprotein complex biogenesis (GO:0022613)2.53037824
93nonmotile primary cilium assembly (GO:0035058)2.52749183
94response to interleukin-15 (GO:0070672)2.51950354
95positive regulation of icosanoid secretion (GO:0032305)2.49582984
96negative regulation of reactive oxygen species metabolic process (GO:2000378)2.48686057
97positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.48108477
98regulation of chronic inflammatory response (GO:0002676)2.46677383
99fucosylation (GO:0036065)2.45977479
100sulfur amino acid catabolic process (GO:0000098)2.45765625

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.89131250
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.52881456
3VDR_22108803_ChIP-Seq_LS180_Human3.12808634
4EZH2_22144423_ChIP-Seq_EOC_Human2.70322137
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69266813
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.62888235
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31445215
8ZNF274_21170338_ChIP-Seq_K562_Hela2.29467689
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.28873769
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.26362099
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23359172
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11192698
13FOXP3_21729870_ChIP-Seq_TREG_Human2.10057067
14VDR_23849224_ChIP-Seq_CD4+_Human2.04320677
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00515820
16ETS1_20019798_ChIP-Seq_JURKAT_Human1.98282241
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.92531367
18TP53_22573176_ChIP-Seq_HFKS_Human1.91799320
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.85847735
20EWS_26573619_Chip-Seq_HEK293_Human1.81530841
21MYC_18940864_ChIP-ChIP_HL60_Human1.77672449
22IGF1R_20145208_ChIP-Seq_DFB_Human1.74989847
23GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.72819862
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70060015
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.69498152
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61627867
27IRF1_19129219_ChIP-ChIP_H3396_Human1.60068466
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.59647959
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58095326
30TDRD3_21172665_ChIP-Seq_MCF-7_Human1.54054087
31ETV2_25802403_ChIP-Seq_MESCs_Mouse1.49155737
32ELK1_19687146_ChIP-ChIP_HELA_Human1.48702719
33TAF2_19829295_ChIP-Seq_ESCs_Human1.47038350
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45852397
35FOXA1_25329375_ChIP-Seq_VCAP_Human1.45600954
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.45600954
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45428735
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44964232
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42891894
40GATA3_26560356_Chip-Seq_TH2_Human1.40819360
41NANOG_20526341_ChIP-Seq_ESCs_Human1.34563664
42TAF15_26573619_Chip-Seq_HEK293_Human1.34433884
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32408331
44GATA3_21878914_ChIP-Seq_MCF-7_Human1.29077932
45GATA6_21074721_ChIP-Seq_CACO-2_Human1.26158910
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24152751
47ERA_21632823_ChIP-Seq_H3396_Human1.23908557
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23435880
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23408716
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23136645
51NCOR_22424771_ChIP-Seq_293T_Human1.22997559
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22406385
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22403303
54P53_21459846_ChIP-Seq_SAOS-2_Human1.21059613
55NANOG_19829295_ChIP-Seq_ESCs_Human1.20509928
56SOX2_19829295_ChIP-Seq_ESCs_Human1.20509928
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19730102
58TTF2_22483619_ChIP-Seq_HELA_Human1.18721659
59ER_23166858_ChIP-Seq_MCF-7_Human1.16716997
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16517675
61GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.15301985
62AR_20517297_ChIP-Seq_VCAP_Human1.14929947
63OCT4_20526341_ChIP-Seq_ESCs_Human1.14748666
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13415659
65ERG_20517297_ChIP-Seq_VCAP_Human1.13162260
66MYC_19829295_ChIP-Seq_ESCs_Human1.12358219
67FUS_26573619_Chip-Seq_HEK293_Human1.11150243
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10962274
69HOXB7_26014856_ChIP-Seq_BT474_Human1.10878380
70TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10663499
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09868300
72FOXH1_21741376_ChIP-Seq_EPCs_Human1.09806025
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09645259
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.09591658
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06974759
76RBPJ_21746931_ChIP-Seq_IB4_Human1.06909019
77CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.06426420
78FOXH1_21741376_ChIP-Seq_ESCs_Human1.06248932
79MYC_18555785_ChIP-Seq_MESCs_Mouse1.05994072
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05070393
81CBP_20019798_ChIP-Seq_JUKART_Human1.05070393
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03617555
83BCL6_27268052_Chip-Seq_Bcells_Human1.03234355
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.02345976
85P300_19829295_ChIP-Seq_ESCs_Human1.00626673
86PHF8_20622853_ChIP-Seq_HELA_Human0.99953881
87TCF4_22108803_ChIP-Seq_LS180_Human0.99601891
88RUNX_20019798_ChIP-Seq_JUKART_Human0.98367275
89CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97963774
90GBX2_23144817_ChIP-Seq_PC3_Human0.95835301
91YY1_22570637_ChIP-Seq_MALME-3M_Human0.94906372
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94275635
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94198537
94EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94174225
95EZH2_27294783_Chip-Seq_NPCs_Mouse0.93215879
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93172329
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92821989
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.92635639
99POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91772979
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90415744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.65938793
2MP0008877_abnormal_DNA_methylation3.40567733
3MP0001873_stomach_inflammation3.16912730
4MP0006292_abnormal_olfactory_placode3.12408223
5MP0009379_abnormal_foot_pigmentation3.05809403
6MP0001835_abnormal_antigen_presentation3.01065395
7MP0002138_abnormal_hepatobiliary_system2.32367732
8MP0003787_abnormal_imprinting2.18201833
9MP0008872_abnormal_physiological_respon2.13798823
10MP0001348_abnormal_lacrimal_gland2.12687235
11MP0003646_muscle_fatigue2.08718232
12MP0002653_abnormal_ependyma_morphology2.07847652
13MP0008875_abnormal_xenobiotic_pharmacok1.93113531
14MP0005551_abnormal_eye_electrophysiolog1.80410038
15MP0004142_abnormal_muscle_tone1.78384438
16MP0004742_abnormal_vestibular_system1.74290520
17MP0000427_abnormal_hair_cycle1.73380109
18MP0005360_urolithiasis1.70302059
19MP0001968_abnormal_touch/_nociception1.66394037
20MP0004885_abnormal_endolymph1.64847401
21MP0005387_immune_system_phenotype1.64250269
22MP0001790_abnormal_immune_system1.64250269
23MP0001800_abnormal_humoral_immune1.63435558
24MP0005645_abnormal_hypothalamus_physiol1.62809088
25MP0003763_abnormal_thymus_physiology1.60733208
26MP0001502_abnormal_circadian_rhythm1.58125518
27MP0006072_abnormal_retinal_apoptosis1.54360722
28MP0001986_abnormal_taste_sensitivity1.53840058
29MP0005084_abnormal_gallbladder_morpholo1.48154286
30MP0002736_abnormal_nociception_after1.48150625
31MP0006276_abnormal_autonomic_nervous1.46022391
32MP0002163_abnormal_gland_morphology1.43913153
33MP0002148_abnormal_hypersensitivity_rea1.39568158
34MP0003866_abnormal_defecation1.37304215
35MP0000685_abnormal_immune_system1.34692756
36MP0001919_abnormal_reproductive_system1.33331664
37MP0005389_reproductive_system_phenotype1.31340543
38MP0006036_abnormal_mitochondrial_physio1.29958280
39MP0009785_altered_susceptibility_to1.29115703
40MP0004147_increased_porphyrin_level1.29051667
41MP0003283_abnormal_digestive_organ1.28218756
42MP0002006_tumorigenesis1.27691630
43MP0002166_altered_tumor_susceptibility1.27336294
44MP0002938_white_spotting1.23490727
45MP0002723_abnormal_immune_serum1.22550984
46MP0002876_abnormal_thyroid_physiology1.22482529
47MP0005000_abnormal_immune_tolerance1.21682984
48MP0005670_abnormal_white_adipose1.21103675
49MP0006035_abnormal_mitochondrial_morpho1.20959429
50MP0002160_abnormal_reproductive_system1.18960241
51MP0001485_abnormal_pinna_reflex1.18000123
52MP0010155_abnormal_intestine_physiology1.17954190
53MP0002638_abnormal_pupillary_reflex1.16329431
54MP0005377_hearing/vestibular/ear_phenot1.16110995
55MP0003878_abnormal_ear_physiology1.16110995
56MP0003136_yellow_coat_color1.14864012
57MP0003786_premature_aging1.12898933
58MP0005025_abnormal_response_to1.11665224
59MP0001663_abnormal_digestive_system1.10896068
60MP0002272_abnormal_nervous_system1.09592653
61MP0003122_maternal_imprinting1.08019659
62MP0001529_abnormal_vocalization1.07873591
63MP0001819_abnormal_immune_cell1.07835454
64MP0009333_abnormal_splenocyte_physiolog1.07277633
65MP0002420_abnormal_adaptive_immunity1.07238605
66MP0002095_abnormal_skin_pigmentation1.06175240
67MP0001440_abnormal_grooming_behavior1.06083474
68MP0002837_dystrophic_cardiac_calcinosis1.04963465
69MP0000604_amyloidosis1.04934530
70MP0003183_abnormal_peptide_metabolism1.03662274
71MP0002102_abnormal_ear_morphology1.01296496
72MP0005253_abnormal_eye_physiology1.01291593
73MP0001845_abnormal_inflammatory_respons1.00734981
74MP0005174_abnormal_tail_pigmentation1.00503468
75MP0003806_abnormal_nucleotide_metabolis0.97242766
76MP0002452_abnormal_antigen_presenting0.96561754
77MP0001501_abnormal_sleep_pattern0.96052378
78MP0005085_abnormal_gallbladder_physiolo0.95561615
79MP0009745_abnormal_behavioral_response0.95336933
80MP0003252_abnormal_bile_duct0.92956999
81MP0000372_irregular_coat_pigmentation0.90782460
82MP0000569_abnormal_digit_pigmentation0.90765958
83MP0002557_abnormal_social/conspecific_i0.89172648
84MP0001970_abnormal_pain_threshold0.88901847
85MP0005365_abnormal_bile_salt0.88630207
86MP0005075_abnormal_melanosome_morpholog0.88573169
87MP0000015_abnormal_ear_pigmentation0.88414653
88MP0002572_abnormal_emotion/affect_behav0.87948639
89MP0009764_decreased_sensitivity_to0.84965779
90MP0003121_genomic_imprinting0.84394997
91MP0002234_abnormal_pharynx_morphology0.82784306
92MP0002405_respiratory_system_inflammati0.82039272
93MP0001293_anophthalmia0.81363777
94MP0005379_endocrine/exocrine_gland_phen0.79687174
95MP0001905_abnormal_dopamine_level0.79481989
96MP0000716_abnormal_immune_system0.78107754
97MP0005195_abnormal_posterior_eye0.77822380
98MP0002733_abnormal_thermal_nociception0.75695287
99MP0001486_abnormal_startle_reflex0.75644430
100MP0002064_seizures0.73927145

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.51616615
2Absent rod-and cone-mediated responses on ERG (HP:0007688)4.05646141
3Abnormality of midbrain morphology (HP:0002418)3.98638598
4Molar tooth sign on MRI (HP:0002419)3.98638598
5IgG deficiency (HP:0004315)3.61489843
6Congenital stationary night blindness (HP:0007642)3.60434884
7Reticulocytopenia (HP:0001896)3.56796963
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.55160962
9Abnormality of alanine metabolism (HP:0010916)3.55160962
10Hyperalaninemia (HP:0003348)3.55160962
11Elevated erythrocyte sedimentation rate (HP:0003565)3.37019751
12Autoimmune hemolytic anemia (HP:0001890)3.33564168
13Abnormal rod and cone electroretinograms (HP:0008323)3.27392051
14Abnormality of cells of the erythroid lineage (HP:0012130)3.24596782
153-Methylglutaconic aciduria (HP:0003535)3.21852273
16Pancreatic cysts (HP:0001737)3.17769056
17Lipid accumulation in hepatocytes (HP:0006561)3.02356117
18Pendular nystagmus (HP:0012043)3.01065135
19Acute necrotizing encephalopathy (HP:0006965)2.93751180
20Increased hepatocellular lipid droplets (HP:0006565)2.90195434
21Abnormal number of erythroid precursors (HP:0012131)2.69150874
22Acute encephalopathy (HP:0006846)2.68703354
23Aplasia/Hypoplasia of the spleen (HP:0010451)2.68689510
24Mitochondrial inheritance (HP:0001427)2.67883596
25Asplenia (HP:0001746)2.65342799
26Nephronophthisis (HP:0000090)2.64973286
27Abnormality of the prostate (HP:0008775)2.64703798
28Papilledema (HP:0001085)2.59646556
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59444015
30Abolished electroretinogram (ERG) (HP:0000550)2.57525071
31Pancreatic fibrosis (HP:0100732)2.55654446
32Increased CSF lactate (HP:0002490)2.55344929
33Abnormality of the renal cortex (HP:0011035)2.55243407
34B lymphocytopenia (HP:0010976)2.53032436
35Macrocytic anemia (HP:0001972)2.50715906
36Decreased central vision (HP:0007663)2.45886529
37Optic disc pallor (HP:0000543)2.45441621
38Dyschromatopsia (HP:0007641)2.39497075
39Rib fusion (HP:0000902)2.38577482
40Abnormal mitochondria in muscle tissue (HP:0008316)2.38549834
41Progressive macrocephaly (HP:0004481)2.38428967
42Congenital, generalized hypertrichosis (HP:0004540)2.38101353
43Abnormality of the renal medulla (HP:0100957)2.36934383
44Abnormality of B cell number (HP:0010975)2.32837873
45Type II lissencephaly (HP:0007260)2.32270973
46Septo-optic dysplasia (HP:0100842)2.31450492
47Renal Fanconi syndrome (HP:0001994)2.29803990
48Hypoplasia of the ulna (HP:0003022)2.25126208
49Aplasia/Hypoplasia of the ulna (HP:0006495)2.22656684
50Increased serum lactate (HP:0002151)2.22372331
51Inability to walk (HP:0002540)2.20151643
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.18556222
53True hermaphroditism (HP:0010459)2.16357210
54Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15819339
55Absent thumb (HP:0009777)2.12552874
56Hypoplasia of the radius (HP:0002984)2.11649128
57Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07734415
58Abnormal drinking behavior (HP:0030082)2.05617332
59Polydipsia (HP:0001959)2.05617332
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05250053
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05250053
62Confusion (HP:0001289)2.05165104
63Attenuation of retinal blood vessels (HP:0007843)2.03931756
64Conical tooth (HP:0000698)2.00046040
65Increased corneal curvature (HP:0100692)1.99126619
66Keratoconus (HP:0000563)1.99126619
67Sclerocornea (HP:0000647)1.98439083
68Forearm undergrowth (HP:0009821)1.97750986
69Abnormal respiratory motile cilium physiology (HP:0012261)1.97463979
70Chronic bronchitis (HP:0004469)1.96166009
71Abnormal ciliary motility (HP:0012262)1.95246585
72Medial flaring of the eyebrow (HP:0010747)1.94220143
73Increased neuronal autofluorescent lipopigment (HP:0002074)1.93458915
74Renal cortical cysts (HP:0000803)1.91644096
75Neutropenia (HP:0001875)1.87770030
76Lactic acidosis (HP:0003128)1.86865573
77Exertional dyspnea (HP:0002875)1.86364587
78Panhypogammaglobulinemia (HP:0003139)1.84362795
79Abnormality of T cell physiology (HP:0011840)1.83515133
80Abnormality of T cells (HP:0002843)1.83031235
81Gastrointestinal infarctions (HP:0005244)1.79743097
82Abnormal respiratory epithelium morphology (HP:0012253)1.79182565
83Abnormal respiratory motile cilium morphology (HP:0005938)1.79182565
84Methylmalonic acidemia (HP:0002912)1.77257450
85Hepatocellular necrosis (HP:0001404)1.76698895
86Lethargy (HP:0001254)1.76102836
87Absent/shortened dynein arms (HP:0200106)1.75945918
88Dynein arm defect of respiratory motile cilia (HP:0012255)1.75945918
89Aplastic anemia (HP:0001915)1.73879753
90Visual hallucinations (HP:0002367)1.72994865
91Abnormality of urine glucose concentration (HP:0011016)1.72289828
92Glycosuria (HP:0003076)1.72289828
93Cerebral edema (HP:0002181)1.72024580
94Pancytopenia (HP:0001876)1.71387705
95Cleft eyelid (HP:0000625)1.69802480
96Stenosis of the external auditory canal (HP:0000402)1.69008740
97Hypoproteinemia (HP:0003075)1.68923352
98Abnormality of male internal genitalia (HP:0000022)1.68229546
99Supernumerary spleens (HP:0009799)1.66734491
100Colon cancer (HP:0003003)1.66600284

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.44670427
2TXK4.18218595
3ADRBK23.22249136
4FRK2.74910031
5ZAK2.49966014
6WNK32.45375526
7NEK12.35163212
8GRK12.32325847
9MAP4K12.26444684
10TLK12.14117121
11PINK12.12456159
12NUAK12.08884045
13BMPR1B1.99745894
14ITK1.98008900
15VRK21.96092416
16WNK41.81656688
17EIF2AK11.80113719
18TAOK31.64485546
19CDK81.59127220
20MAP3K111.55473736
21TEC1.50948307
22CDK191.50299179
23MAP2K61.37638015
24BCKDK1.28017810
25DYRK21.20794622
26EPHB21.15786708
27BTK1.04862057
28OXSR11.02424115
29JAK31.02207507
30TYRO30.99624717
31CAMKK20.93508336
32STK160.92168172
33BUB10.92014454
34LCK0.91733217
35TRIM280.91332435
36SYK0.90212486
37EIF2AK30.90031047
38VRK10.89289614
39PIK3CA0.88960383
40FES0.85144491
41STK30.83480546
42GRK60.83056804
43KIT0.82811905
44AKT30.81337378
45ADRBK10.81169127
46ACVR1B0.80162233
47PAK30.78013850
48PLK40.76513181
49TIE10.75938559
50EPHA40.75609054
51IGF1R0.75489761
52IKBKB0.75163433
53STK390.74070118
54PRKCQ0.73215764
55EIF2AK20.72320306
56WEE10.70673038
57INSRR0.64772405
58LYN0.64345596
59CAMK10.63111965
60ERBB30.63107163
61GRK70.60866485
62LRRK20.60818150
63PRKCH0.60236263
64MAP3K120.59302554
65IKBKE0.57999696
66TGFBR10.55707179
67PRKCZ0.54140302
68CSNK1G20.53966506
69CSK0.53773537
70CSNK1A10.52544843
71PHKG20.52317034
72PHKG10.52317034
73NEK20.52155184
74NME20.51561097
75PRKCG0.51457522
76PRKACA0.49984724
77CSNK2A20.49186716
78CLK10.48337052
79NME10.45462724
80PRKCA0.44916437
81CAMK2A0.44486579
82PRKCD0.44415994
83NTRK20.44029458
84PBK0.43882689
85CSNK1G30.43383475
86STK38L0.43284492
87MAPK130.42553373
88CSNK2A10.42301910
89RPS6KA50.41298439
90CHEK20.38745343
91PASK0.37621083
92PLK30.37540617
93MAP3K140.37534710
94CAMK2D0.36899597
95BLK0.35981957
96ATR0.35384541
97MINK10.34979706
98PLK10.34543695
99ERBB20.34267967
100GRK50.33664655

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.80913172
2Asthma_Homo sapiens_hsa053103.53638064
3Oxidative phosphorylation_Homo sapiens_hsa001903.17805492
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.07190346
5Allograft rejection_Homo sapiens_hsa053303.07136685
6Autoimmune thyroid disease_Homo sapiens_hsa053202.93915326
7Primary immunodeficiency_Homo sapiens_hsa053402.44473114
8Parkinsons disease_Homo sapiens_hsa050122.43434844
9Proteasome_Homo sapiens_hsa030502.43323023
10Graft-versus-host disease_Homo sapiens_hsa053322.21687882
11RNA polymerase_Homo sapiens_hsa030202.18113009
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07347730
13Linoleic acid metabolism_Homo sapiens_hsa005912.06652462
14Type I diabetes mellitus_Homo sapiens_hsa049401.85808600
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85522096
16Cardiac muscle contraction_Homo sapiens_hsa042601.81586856
17Basal transcription factors_Homo sapiens_hsa030221.77828700
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67638766
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63412721
20RNA degradation_Homo sapiens_hsa030181.59873018
21Huntingtons disease_Homo sapiens_hsa050161.59168815
22Alzheimers disease_Homo sapiens_hsa050101.59168760
23Protein export_Homo sapiens_hsa030601.54354454
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54052281
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53888967
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52477091
27Fat digestion and absorption_Homo sapiens_hsa049751.45982602
28T cell receptor signaling pathway_Homo sapiens_hsa046601.41039916
29Homologous recombination_Homo sapiens_hsa034401.40361486
30Phototransduction_Homo sapiens_hsa047441.39137563
31Vitamin digestion and absorption_Homo sapiens_hsa049771.38796578
32Caffeine metabolism_Homo sapiens_hsa002321.37686976
33Hematopoietic cell lineage_Homo sapiens_hsa046401.37227642
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33407636
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29670195
36Ether lipid metabolism_Homo sapiens_hsa005651.24357844
37Pyrimidine metabolism_Homo sapiens_hsa002401.24178596
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.20085145
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16767651
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15429353
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14439439
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11544105
43Antigen processing and presentation_Homo sapiens_hsa046121.04150749
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04077535
45Nucleotide excision repair_Homo sapiens_hsa034200.99217532
46Tryptophan metabolism_Homo sapiens_hsa003800.95174828
47Nitrogen metabolism_Homo sapiens_hsa009100.94870022
48Rheumatoid arthritis_Homo sapiens_hsa053230.93279137
49Chemical carcinogenesis_Homo sapiens_hsa052040.90269553
50One carbon pool by folate_Homo sapiens_hsa006700.86179419
51Sulfur metabolism_Homo sapiens_hsa009200.84978497
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84150618
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82958552
54Purine metabolism_Homo sapiens_hsa002300.82559795
55Arachidonic acid metabolism_Homo sapiens_hsa005900.82489410
56Sulfur relay system_Homo sapiens_hsa041220.79508486
57Fanconi anemia pathway_Homo sapiens_hsa034600.78752736
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.76128692
59Mismatch repair_Homo sapiens_hsa034300.73561744
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72286244
61Peroxisome_Homo sapiens_hsa041460.70698541
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70328614
63Measles_Homo sapiens_hsa051620.69402673
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.67007045
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.64221013
66Glycerolipid metabolism_Homo sapiens_hsa005610.63712885
67Mineral absorption_Homo sapiens_hsa049780.62570917
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60888894
69Retinol metabolism_Homo sapiens_hsa008300.59097845
70Propanoate metabolism_Homo sapiens_hsa006400.58753063
71Nicotine addiction_Homo sapiens_hsa050330.57968277
72Metabolic pathways_Homo sapiens_hsa011000.57729316
73Butanoate metabolism_Homo sapiens_hsa006500.55281680
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55164516
75Folate biosynthesis_Homo sapiens_hsa007900.53521261
76Vitamin B6 metabolism_Homo sapiens_hsa007500.52197679
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50597909
78Olfactory transduction_Homo sapiens_hsa047400.44832881
79Fatty acid degradation_Homo sapiens_hsa000710.43610054
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41477690
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39246424
82Collecting duct acid secretion_Homo sapiens_hsa049660.38559592
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.37989639
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37933308
85Taste transduction_Homo sapiens_hsa047420.37484461
86Spliceosome_Homo sapiens_hsa030400.37335291
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36547026
88Fatty acid biosynthesis_Homo sapiens_hsa000610.35646880
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.35390722
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.34653539
91Systemic lupus erythematosus_Homo sapiens_hsa053220.32340605
92Morphine addiction_Homo sapiens_hsa050320.31644437
93DNA replication_Homo sapiens_hsa030300.29750369
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29199592
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27846305
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27586734
97Ovarian steroidogenesis_Homo sapiens_hsa049130.27243778
98Staphylococcus aureus infection_Homo sapiens_hsa051500.26633186
99Sphingolipid metabolism_Homo sapiens_hsa006000.23793070
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22784740

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »