RPL21P111

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)6.13118621
2ATP synthesis coupled proton transport (GO:0015986)6.13118621
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.00124556
4ribosomal small subunit assembly (GO:0000028)4.99543904
5viral transcription (GO:0019083)4.70224160
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.65271796
7respiratory electron transport chain (GO:0022904)4.56994300
8electron transport chain (GO:0022900)4.53551206
9translational termination (GO:0006415)4.53022321
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.44692572
11cotranslational protein targeting to membrane (GO:0006613)4.40298828
12protein targeting to ER (GO:0045047)4.37854162
13DNA deamination (GO:0045006)4.26302306
14protein neddylation (GO:0045116)4.22825814
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.18942184
16protein localization to endoplasmic reticulum (GO:0070972)4.16722322
17positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.15621217
18translational elongation (GO:0006414)4.00491435
19ribosomal large subunit biogenesis (GO:0042273)3.85185621
20regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.83243867
21protein complex biogenesis (GO:0070271)3.76410056
22ATP biosynthetic process (GO:0006754)3.69164266
23respiratory chain complex IV assembly (GO:0008535)3.64538410
24hydrogen ion transmembrane transport (GO:1902600)3.63138849
25regulation of isotype switching to IgG isotypes (GO:0048302)3.60990750
26purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.56393873
27purine nucleoside triphosphate biosynthetic process (GO:0009145)3.56026711
28maturation of SSU-rRNA (GO:0030490)3.54015666
29negative regulation of heart rate (GO:0010459)3.47973586
30translation (GO:0006412)3.44764858
31nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41060346
32proton transport (GO:0015992)3.40888158
33positive regulation of interleukin-17 production (GO:0032740)3.39908552
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.39154584
35water-soluble vitamin biosynthetic process (GO:0042364)3.38938582
36cytochrome complex assembly (GO:0017004)3.36402974
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.36365668
38hydrogen transport (GO:0006818)3.34361862
39mitochondrial respiratory chain complex assembly (GO:0033108)3.33814817
40viral life cycle (GO:0019058)3.29583967
41cellular protein complex disassembly (GO:0043624)3.27983941
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.26780375
43NADH dehydrogenase complex assembly (GO:0010257)3.26780375
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26780375
45regulation of chronic inflammatory response (GO:0002676)3.22311529
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.19185638
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.19185638
48translational initiation (GO:0006413)3.19155953
49GTP biosynthetic process (GO:0006183)3.15954298
50regulation of regulatory T cell differentiation (GO:0045589)3.11271905
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.11223987
52termination of RNA polymerase III transcription (GO:0006386)3.11223987
53regulation of immunoglobulin secretion (GO:0051023)3.06837779
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.05166587
55behavioral response to nicotine (GO:0035095)3.00254903
56ribosomal small subunit biogenesis (GO:0042274)3.00191543
57negative regulation of mast cell activation (GO:0033004)2.98569690
58proteasome assembly (GO:0043248)2.93455392
59kynurenine metabolic process (GO:0070189)2.92397206
60ribonucleoside triphosphate biosynthetic process (GO:0009201)2.91753806
61tryptophan catabolic process (GO:0006569)2.90274426
62indole-containing compound catabolic process (GO:0042436)2.90274426
63indolalkylamine catabolic process (GO:0046218)2.90274426
64protein targeting to membrane (GO:0006612)2.84797719
65S-adenosylmethionine metabolic process (GO:0046500)2.80858353
66fucose catabolic process (GO:0019317)2.79779096
67L-fucose metabolic process (GO:0042354)2.79779096
68L-fucose catabolic process (GO:0042355)2.79779096
69platelet dense granule organization (GO:0060155)2.79393458
70regulation of cellular amino acid metabolic process (GO:0006521)2.78727107
71cytidine deamination (GO:0009972)2.78092061
72cytidine metabolic process (GO:0046087)2.78092061
73cytidine catabolic process (GO:0006216)2.78092061
74signal peptide processing (GO:0006465)2.62022591
75DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.61347701
76positive regulation of T cell mediated cytotoxicity (GO:0001916)2.60259815
77positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.59948284
78protein-cofactor linkage (GO:0018065)2.59545082
79rRNA catabolic process (GO:0016075)2.58782124
80indolalkylamine metabolic process (GO:0006586)2.58524939
81mast cell activation (GO:0045576)2.57472370
82protein complex disassembly (GO:0043241)2.56004198
83chaperone-mediated protein transport (GO:0072321)2.53909183
84RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.53852947
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.53725755
86signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.53013786
87signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.53013786
88signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.53013786
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.52615624
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.49301055
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.49301055
92nucleoside triphosphate biosynthetic process (GO:0009142)2.48618645
93macromolecular complex disassembly (GO:0032984)2.46994556
94positive regulation of defense response to virus by host (GO:0002230)2.46291084
95UTP biosynthetic process (GO:0006228)2.45717002
96axoneme assembly (GO:0035082)2.44882426
97positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.44869610
98nuclear-transcribed mRNA catabolic process (GO:0000956)2.44756197
99cellular component biogenesis (GO:0044085)2.44347983
100antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.43926507

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.20242186
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.97570376
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.44216330
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.20619124
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.16930668
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.68670998
7VDR_22108803_ChIP-Seq_LS180_Human2.64398241
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59553912
9VDR_23849224_ChIP-Seq_CD4+_Human2.29686608
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28921974
11ZNF274_21170338_ChIP-Seq_K562_Hela2.26017251
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15728797
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.13538364
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11398801
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.10198001
16ELK1_19687146_ChIP-ChIP_HELA_Human2.04991125
17BP1_19119308_ChIP-ChIP_Hs578T_Human1.98284702
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91740605
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91552993
20EZH2_22144423_ChIP-Seq_EOC_Human1.82908629
21IGF1R_20145208_ChIP-Seq_DFB_Human1.74154405
22EWS_26573619_Chip-Seq_HEK293_Human1.74100175
23TAF15_26573619_Chip-Seq_HEK293_Human1.73559431
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70404692
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.68299599
26FOXP3_21729870_ChIP-Seq_TREG_Human1.68147239
27TP53_22573176_ChIP-Seq_HFKS_Human1.64921803
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64407551
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63556591
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.58625812
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58061498
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57568940
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.54747957
34FOXA1_27270436_Chip-Seq_PROSTATE_Human1.53842050
35FOXA1_25329375_ChIP-Seq_VCAP_Human1.53842050
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51942394
37MYC_18940864_ChIP-ChIP_HL60_Human1.49267400
38AR_20517297_ChIP-Seq_VCAP_Human1.49014707
39GATA3_26560356_Chip-Seq_TH2_Human1.45606564
40GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.44873229
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42441120
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37734758
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.37470650
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37295862
45P300_19829295_ChIP-Seq_ESCs_Human1.34836074
46AUTS2_25519132_ChIP-Seq_293T-REX_Human1.34638352
47ER_23166858_ChIP-Seq_MCF-7_Human1.32382573
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.31899727
49FUS_26573619_Chip-Seq_HEK293_Human1.31028613
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30188740
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29983697
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28950335
53CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.27956364
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27664360
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26869936
56SOX2_19829295_ChIP-Seq_ESCs_Human1.26244376
57NANOG_19829295_ChIP-Seq_ESCs_Human1.26244376
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.24672562
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24278174
60TAF2_19829295_ChIP-Seq_ESCs_Human1.23907203
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23166629
62MYC_18555785_ChIP-Seq_MESCs_Mouse1.19333263
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18661624
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.16837931
65ERG_20517297_ChIP-Seq_VCAP_Human1.16795488
66NCOR_22424771_ChIP-Seq_293T_Human1.16175171
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.15961572
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15933792
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15797432
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.13783543
71PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.12042267
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10999533
73FOXH1_21741376_ChIP-Seq_EPCs_Human1.10787226
74IRF1_19129219_ChIP-ChIP_H3396_Human1.10064997
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09960314
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08268144
77NANOG_20526341_ChIP-Seq_ESCs_Human1.07963610
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.07684426
79CBP_20019798_ChIP-Seq_JUKART_Human1.07079959
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07079959
81MYC_19829295_ChIP-Seq_ESCs_Human1.05568550
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04844504
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04011422
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01175979
85TCF4_22108803_ChIP-Seq_LS180_Human1.00873394
86TTF2_22483619_ChIP-Seq_HELA_Human1.00375757
87BCAT_22108803_ChIP-Seq_LS180_Human0.99928303
88GATA6_21074721_ChIP-Seq_CACO-2_Human0.98142168
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98060177
90HOXB7_26014856_ChIP-Seq_BT474_Human0.97120926
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96517033
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.96275706
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96113397
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96013341
95RBPJ_21746931_ChIP-Seq_IB4_Human0.95882344
96ERA_21632823_ChIP-Seq_H3396_Human0.94625236
97FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93978889
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93857200
99GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93838422
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91947925

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.08057239
2MP0005671_abnormal_response_to3.50711702
3MP0009379_abnormal_foot_pigmentation3.35069328
4MP0008877_abnormal_DNA_methylation2.61353159
5MP0008872_abnormal_physiological_respon2.46508849
6MP0003806_abnormal_nucleotide_metabolis2.41862380
7MP0003646_muscle_fatigue2.34997555
8MP0001873_stomach_inflammation2.22315776
9MP0002837_dystrophic_cardiac_calcinosis2.20326994
10MP0004147_increased_porphyrin_level2.19268270
11MP0009785_altered_susceptibility_to2.18296464
12MP0008875_abnormal_xenobiotic_pharmacok2.12378414
13MP0006072_abnormal_retinal_apoptosis2.11795870
14MP0005645_abnormal_hypothalamus_physiol2.10626622
15MP0003195_calcinosis2.04717137
16MP0004142_abnormal_muscle_tone2.02691756
17MP0000685_abnormal_immune_system1.86047009
18MP0000372_irregular_coat_pigmentation1.85843593
19MP0005387_immune_system_phenotype1.78732480
20MP0001790_abnormal_immune_system1.78732480
21MP0004885_abnormal_endolymph1.78566277
22MP0005075_abnormal_melanosome_morpholog1.73230747
23MP0002876_abnormal_thyroid_physiology1.73156153
24MP0001800_abnormal_humoral_immune1.71318800
25MP0006292_abnormal_olfactory_placode1.70054081
26MP0002102_abnormal_ear_morphology1.63401275
27MP0002166_altered_tumor_susceptibility1.62913459
28MP0001986_abnormal_taste_sensitivity1.61811961
29MP0001968_abnormal_touch/_nociception1.58559864
30MP0004145_abnormal_muscle_electrophysio1.58404716
31MP0006036_abnormal_mitochondrial_physio1.52770375
32MP0005000_abnormal_immune_tolerance1.52323072
33MP0002148_abnormal_hypersensitivity_rea1.47157234
34MP0005551_abnormal_eye_electrophysiolog1.46259159
35MP0009764_decreased_sensitivity_to1.44965856
36MP0002638_abnormal_pupillary_reflex1.41759470
37MP0005646_abnormal_pituitary_gland1.37843666
38MP0002006_tumorigenesis1.34315679
39MP0010386_abnormal_urinary_bladder1.34225807
40MP0001919_abnormal_reproductive_system1.33700960
41MP0009333_abnormal_splenocyte_physiolog1.32272831
42MP0002736_abnormal_nociception_after1.31921523
43MP0002723_abnormal_immune_serum1.27965566
44MP0003787_abnormal_imprinting1.27801117
45MP0002163_abnormal_gland_morphology1.25732148
46MP0002138_abnormal_hepatobiliary_system1.24832145
47MP0003786_premature_aging1.22049148
48MP0005389_reproductive_system_phenotype1.19886705
49MP0002272_abnormal_nervous_system1.18944700
50MP0005253_abnormal_eye_physiology1.18861037
51MP0005360_urolithiasis1.17804172
52MP0008995_early_reproductive_senescence1.14408727
53MP0002420_abnormal_adaptive_immunity1.14079614
54MP0009745_abnormal_behavioral_response1.13782865
55MP0005379_endocrine/exocrine_gland_phen1.12920929
56MP0002452_abnormal_antigen_presenting1.12664643
57MP0001819_abnormal_immune_cell1.12012796
58MP0003011_delayed_dark_adaptation1.11821452
59MP0001905_abnormal_dopamine_level1.09857021
60MP0005636_abnormal_mineral_homeostasis1.09409522
61MP0002277_abnormal_respiratory_mucosa1.09112977
62MP0001984_abnormal_olfaction1.08281537
63MP0002693_abnormal_pancreas_physiology1.07638630
64MP0004742_abnormal_vestibular_system1.07213825
65MP0001853_heart_inflammation1.07188252
66MP0003186_abnormal_redox_activity1.06441257
67MP0005084_abnormal_gallbladder_morpholo1.03133809
68MP0006082_CNS_inflammation1.02169250
69MP0001485_abnormal_pinna_reflex1.01374302
70MP0002938_white_spotting1.01082069
71MP0010155_abnormal_intestine_physiology1.00683446
72MP0001348_abnormal_lacrimal_gland1.00412348
73MP0003866_abnormal_defecation1.00342329
74MP0005025_abnormal_response_to0.98150646
75MP0002234_abnormal_pharynx_morphology0.98115660
76MP0001845_abnormal_inflammatory_respons0.96929912
77MP0005332_abnormal_amino_acid0.95906244
78MP0001501_abnormal_sleep_pattern0.95658069
79MP0001765_abnormal_ion_homeostasis0.95060130
80MP0005408_hypopigmentation0.92105323
81MP0009046_muscle_twitch0.90976780
82MP0003763_abnormal_thymus_physiology0.90971702
83MP0001970_abnormal_pain_threshold0.90859944
84MP0003724_increased_susceptibility_to0.90789677
85MP0000631_abnormal_neuroendocrine_gland0.86843715
86MP0001764_abnormal_homeostasis0.86459355
87MP0005367_renal/urinary_system_phenotyp0.84903941
88MP0000516_abnormal_urinary_system0.84903941
89MP0004019_abnormal_vitamin_homeostasis0.84850449
90MP0005085_abnormal_gallbladder_physiolo0.84560593
91MP0003878_abnormal_ear_physiology0.83386086
92MP0005377_hearing/vestibular/ear_phenot0.83386086
93MP0002160_abnormal_reproductive_system0.82260684
94MP0003880_abnormal_central_pattern0.78652968
95MP0004381_abnormal_hair_follicle0.75447981
96MP0001440_abnormal_grooming_behavior0.74629181
97MP0002933_joint_inflammation0.74549913
98MP0003436_decreased_susceptibility_to0.74527148
99MP0000716_abnormal_immune_system0.74365843
100MP0004043_abnormal_pH_regulation0.72287446

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.05804010
2Mitochondrial inheritance (HP:0001427)4.69331385
3Abnormal mitochondria in muscle tissue (HP:0008316)4.36152369
4Acute encephalopathy (HP:0006846)4.32230782
5Progressive macrocephaly (HP:0004481)4.28749770
6Increased CSF lactate (HP:0002490)4.20403137
7Hepatocellular necrosis (HP:0001404)4.15254038
8Increased hepatocellular lipid droplets (HP:0006565)4.13663463
9Lipid accumulation in hepatocytes (HP:0006561)3.82892903
10Hepatic necrosis (HP:0002605)3.79162343
113-Methylglutaconic aciduria (HP:0003535)3.79050005
12IgG deficiency (HP:0004315)3.61063443
13Stomatitis (HP:0010280)3.54594483
14Congenital, generalized hypertrichosis (HP:0004540)3.48148418
15Congenital stationary night blindness (HP:0007642)3.32536415
16Renal Fanconi syndrome (HP:0001994)3.21565086
17Cerebral edema (HP:0002181)3.15017513
18Elevated erythrocyte sedimentation rate (HP:0003565)3.10647457
19Exertional dyspnea (HP:0002875)3.09798344
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.03359817
21Optic disc pallor (HP:0000543)3.02191769
22Molar tooth sign on MRI (HP:0002419)3.00415296
23Abnormality of midbrain morphology (HP:0002418)3.00415296
24Increased intramyocellular lipid droplets (HP:0012240)2.95364142
25Methylmalonic acidemia (HP:0002912)2.86849485
26Pancreatic cysts (HP:0001737)2.86635709
27Increased IgM level (HP:0003496)2.76238680
28Reticulocytopenia (HP:0001896)2.75155582
29Abnormality of cells of the erythroid lineage (HP:0012130)2.73331393
30Abnormal rod and cone electroretinograms (HP:0008323)2.67937012
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.67791388
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.67791388
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.60934887
34Aplastic anemia (HP:0001915)2.59099821
35Increased serum lactate (HP:0002151)2.58211714
36Macrocytic anemia (HP:0001972)2.54724060
37Abnormality of urine glucose concentration (HP:0011016)2.52240313
38Glycosuria (HP:0003076)2.52240313
39Lactic acidosis (HP:0003128)2.51015249
40Hypoproteinemia (HP:0003075)2.50592861
41Increased muscle lipid content (HP:0009058)2.46867521
42Respiratory failure (HP:0002878)2.46744521
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.45930622
44Leukodystrophy (HP:0002415)2.38603526
45Methylmalonic aciduria (HP:0012120)2.28105347
46Lethargy (HP:0001254)2.27425266
47Abnormality of the renal cortex (HP:0011035)2.27018888
48Nephronophthisis (HP:0000090)2.26731011
49Abolished electroretinogram (ERG) (HP:0000550)2.21457863
50Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20826134
51Pancreatic fibrosis (HP:0100732)2.20727938
52Abnormal number of erythroid precursors (HP:0012131)2.19459061
53Abnormality of B cell number (HP:0010975)2.16011482
54Severe combined immunodeficiency (HP:0004430)2.13543147
55Attenuation of retinal blood vessels (HP:0007843)2.10224959
56Abnormality of renal resorption (HP:0011038)2.09846333
57Hyperphosphaturia (HP:0003109)2.08450227
58Respiratory difficulties (HP:0002880)2.06508727
59Abnormality of vitamin B metabolism (HP:0004340)2.05085366
60Thyroiditis (HP:0100646)2.04079803
61Pendular nystagmus (HP:0012043)2.02625410
62Exercise intolerance (HP:0003546)2.02045231
63Type II lissencephaly (HP:0007260)2.01964517
64True hermaphroditism (HP:0010459)1.99086054
65Constricted visual fields (HP:0001133)1.98460122
66Chronic diarrhea (HP:0002028)1.98404611
67Abnormality of the vitamin B12 metabolism (HP:0004341)1.95653909
68Decreased central vision (HP:0007663)1.94341935
69Medial flaring of the eyebrow (HP:0010747)1.92543295
70Aplasia/hypoplasia of the uterus (HP:0008684)1.91461324
71Abnormality of the renal medulla (HP:0100957)1.89284294
72Hypoplasia of the ulna (HP:0003022)1.87394460
73Renal cortical cysts (HP:0000803)1.85968454
74Abnormality of the prostate (HP:0008775)1.85748921
75B lymphocytopenia (HP:0010976)1.84833498
76Hypothermia (HP:0002045)1.81266234
77Abnormal albumin level (HP:0012116)1.81165239
78Hypoalbuminemia (HP:0003073)1.81165239
79Septo-optic dysplasia (HP:0100842)1.81115082
80Aplasia/Hypoplasia of the spleen (HP:0010451)1.80902346
81Sclerocornea (HP:0000647)1.79394274
82Abnormality of T cells (HP:0002843)1.79195076
83Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77950129
84Dicarboxylic aciduria (HP:0003215)1.77950129
85Testicular atrophy (HP:0000029)1.77014773
86Absent thumb (HP:0009777)1.76477227
87Hypoplasia of the uterus (HP:0000013)1.76206038
88Pancytopenia (HP:0001876)1.75732333
89Pallor (HP:0000980)1.75656529
90X-linked dominant inheritance (HP:0001423)1.73616873
91Ketosis (HP:0001946)1.73168130
92Abnormality of T cell number (HP:0011839)1.72350772
93Hypomagnesemia (HP:0002917)1.71961449
94Hyperglycinemia (HP:0002154)1.71525362
95Type 2 muscle fiber atrophy (HP:0003554)1.71301473
96Aplasia/Hypoplasia of the ulna (HP:0006495)1.71031754
97Abnormality of DNA repair (HP:0003254)1.70747324
98Polydipsia (HP:0001959)1.69383206
99Abnormal drinking behavior (HP:0030082)1.69383206
100Abnormality of T cell physiology (HP:0011840)1.69218761

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.05257517
2ADRBK22.84775293
3TLK12.80847602
4FRK2.79511112
5ZAK2.79495195
6MAP3K122.77083734
7GRK12.71414258
8MAP4K22.59189891
9CDK192.52650208
10NUAK12.40345978
11PINK12.37095036
12VRK22.19262608
13MAP4K12.09185812
14NME12.03650004
15EIF2AK31.92028387
16WNK41.87365813
17TAOK31.80475631
18MST41.77324363
19PASK1.73101805
20TEC1.73061728
21OXSR11.73060047
22MYLK1.72437198
23KDR1.56816973
24ITK1.50950642
25CAMKK21.46449181
26WNK31.40078283
27TIE11.38834613
28EIF2AK11.31075153
29VRK11.20431300
30BCKDK1.19309175
31IKBKB1.18860202
32TRIM281.16498426
33BMPR21.16375358
34INSRR1.14989022
35MUSK1.14568908
36MAP2K61.13296319
37STK161.09861538
38PHKG11.08941207
39PHKG21.08941207
40BMPR1B1.07689055
41STK391.05291592
42KIT1.03789294
43BTK0.98457205
44DYRK20.98142250
45DAPK20.93875504
46PIK3CA0.93775500
47PAK30.86095394
48ERBB30.83661383
49SCYL20.82251626
50DAPK10.81455806
51CSF1R0.80962315
52LYN0.80189116
53MAP3K40.79710851
54SYK0.79233519
55PLK40.78166290
56PRKCQ0.71021982
57DAPK30.70677096
58CSNK1G30.68426235
59EIF2AK20.66472253
60OBSCN0.66332752
61FLT30.65410953
62RPS6KA50.64511797
63CSNK1G20.62764221
64ADRBK10.62639364
65GRK60.61752365
66CSNK1G10.59259858
67CAMKK10.58599253
68NEK10.57455888
69PRKCE0.56621788
70ILK0.54968813
71LCK0.54682963
72PRKACA0.52719184
73FES0.52714005
74PRKCG0.52307666
75NLK0.49872018
76CSNK2A20.49672685
77IGF1R0.49123607
78PRKCA0.48650243
79LRRK20.47504149
80CSNK1A1L0.46194034
81PIK3CG0.45222154
82NME20.44589914
83CSNK1A10.44265629
84ACVR1B0.43848857
85CSNK2A10.42412553
86ERBB20.40806082
87CAMK2A0.40564473
88PLK30.38894450
89MAPK130.37385202
90MAP2K70.36738942
91BUB10.36622855
92PDK20.35529150
93CAMK2D0.35215130
94MAP3K110.34562260
95ROCK10.33656509
96MKNK20.32759118
97ABL10.31601988
98AURKB0.30462041
99PRKG10.30136614
100PLK20.29766446

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.05284029
2Ribosome_Homo sapiens_hsa030103.88625885
3Asthma_Homo sapiens_hsa053103.83076780
4Proteasome_Homo sapiens_hsa030503.31300405
5Allograft rejection_Homo sapiens_hsa053303.16762920
6Protein export_Homo sapiens_hsa030603.15271892
7Parkinsons disease_Homo sapiens_hsa050123.14062068
8Autoimmune thyroid disease_Homo sapiens_hsa053203.00447902
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.88670889
10Type I diabetes mellitus_Homo sapiens_hsa049402.66054350
11Graft-versus-host disease_Homo sapiens_hsa053322.54553466
12Alzheimers disease_Homo sapiens_hsa050102.09967112
13Primary immunodeficiency_Homo sapiens_hsa053402.05568435
14Huntingtons disease_Homo sapiens_hsa050161.97000668
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96976954
16Cardiac muscle contraction_Homo sapiens_hsa042601.94857937
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.94474532
18RNA polymerase_Homo sapiens_hsa030201.88289432
19Homologous recombination_Homo sapiens_hsa034401.59843419
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56647380
21Rheumatoid arthritis_Homo sapiens_hsa053231.42629238
22Antigen processing and presentation_Homo sapiens_hsa046121.40104492
23Linoleic acid metabolism_Homo sapiens_hsa005911.39636468
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33847163
25RNA degradation_Homo sapiens_hsa030181.29588721
26Caffeine metabolism_Homo sapiens_hsa002321.23025504
27Nitrogen metabolism_Homo sapiens_hsa009101.22193276
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20632691
29Hematopoietic cell lineage_Homo sapiens_hsa046401.19752922
30Phototransduction_Homo sapiens_hsa047441.15165752
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12716899
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08915248
33Basal transcription factors_Homo sapiens_hsa030221.07516438
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.03751105
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01082267
36Collecting duct acid secretion_Homo sapiens_hsa049660.99316612
37One carbon pool by folate_Homo sapiens_hsa006700.98836317
38Sulfur metabolism_Homo sapiens_hsa009200.97247839
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93885749
40Tryptophan metabolism_Homo sapiens_hsa003800.93261261
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91760475
42Butanoate metabolism_Homo sapiens_hsa006500.90713667
43Chemical carcinogenesis_Homo sapiens_hsa052040.90471406
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85666566
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84469133
46Viral myocarditis_Homo sapiens_hsa054160.84010676
47Regulation of autophagy_Homo sapiens_hsa041400.79316843
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77294350
49Nucleotide excision repair_Homo sapiens_hsa034200.75238214
50Staphylococcus aureus infection_Homo sapiens_hsa051500.72762061
51Pyrimidine metabolism_Homo sapiens_hsa002400.71800820
52Propanoate metabolism_Homo sapiens_hsa006400.70696803
53Fat digestion and absorption_Homo sapiens_hsa049750.69393011
54Retinol metabolism_Homo sapiens_hsa008300.67479619
55Ether lipid metabolism_Homo sapiens_hsa005650.65896827
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65681654
57Peroxisome_Homo sapiens_hsa041460.65464855
58Arachidonic acid metabolism_Homo sapiens_hsa005900.65160074
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.64555368
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.63812570
61Purine metabolism_Homo sapiens_hsa002300.63112977
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62050872
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61601892
64Mismatch repair_Homo sapiens_hsa034300.60618116
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59867374
66Olfactory transduction_Homo sapiens_hsa047400.57685448
67Systemic lupus erythematosus_Homo sapiens_hsa053220.57158506
68Fanconi anemia pathway_Homo sapiens_hsa034600.56651158
69T cell receptor signaling pathway_Homo sapiens_hsa046600.56033865
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55728909
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55479955
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55106401
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54361908
74Metabolic pathways_Homo sapiens_hsa011000.53828165
75Nicotine addiction_Homo sapiens_hsa050330.49822547
76Folate biosynthesis_Homo sapiens_hsa007900.46415907
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.46065199
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45962254
79RNA transport_Homo sapiens_hsa030130.45476347
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44904467
81Mineral absorption_Homo sapiens_hsa049780.40621958
82Spliceosome_Homo sapiens_hsa030400.40224252
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.37736649
84Vitamin digestion and absorption_Homo sapiens_hsa049770.37547444
85Taste transduction_Homo sapiens_hsa047420.37032978
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.32828190
87Fatty acid degradation_Homo sapiens_hsa000710.28467152
88Leishmaniasis_Homo sapiens_hsa051400.28288648
89Morphine addiction_Homo sapiens_hsa050320.27714046
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27324246
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26355454
92Glutathione metabolism_Homo sapiens_hsa004800.25640895
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24878635
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23237246
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.20618472
96DNA replication_Homo sapiens_hsa030300.19445306
97Malaria_Homo sapiens_hsa051440.18570398
98Serotonergic synapse_Homo sapiens_hsa047260.16605631
99Sulfur relay system_Homo sapiens_hsa041220.16311052
100GABAergic synapse_Homo sapiens_hsa047270.15107294

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