RPL21P112

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.29103162
2translational termination (GO:0006415)6.06055517
3ribosomal small subunit assembly (GO:0000028)5.87258082
4ribosomal large subunit biogenesis (GO:0042273)5.83922689
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.39936033
6positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.37990411
7cotranslational protein targeting to membrane (GO:0006613)5.34764062
8regulation of immunoglobulin secretion (GO:0051023)5.32818690
9protein targeting to ER (GO:0045047)5.28061280
10ATP synthesis coupled proton transport (GO:0015986)5.26385236
11energy coupled proton transport, down electrochemical gradient (GO:0015985)5.26385236
12regulation of isotype switching to IgG isotypes (GO:0048302)5.26241063
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.14326871
14ribosomal small subunit biogenesis (GO:0042274)5.06010147
15translational elongation (GO:0006414)5.05701025
16protein localization to endoplasmic reticulum (GO:0070972)5.01552065
17regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.95491917
18DNA deamination (GO:0045006)4.83969029
19behavioral response to nicotine (GO:0035095)4.80953743
20cellular protein complex disassembly (GO:0043624)4.54199824
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.53781794
22viral life cycle (GO:0019058)4.51012584
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.38413719
24pseudouridine synthesis (GO:0001522)4.16536004
25peptidyl-histidine modification (GO:0018202)4.07585259
26translational initiation (GO:0006413)4.07169677
27regulation of regulatory T cell differentiation (GO:0045589)3.93345873
28protein complex disassembly (GO:0043241)3.79216502
29translation (GO:0006412)3.76886343
30positive regulation of isotype switching (GO:0045830)3.73570500
31positive regulation of interleukin-17 production (GO:0032740)3.70945332
32pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.62550573
33macromolecular complex disassembly (GO:0032984)3.58506697
34positive regulation of DNA recombination (GO:0045911)3.51222663
35protein neddylation (GO:0045116)3.50683242
36ribonucleoprotein complex biogenesis (GO:0022613)3.50130624
37protein targeting to membrane (GO:0006612)3.49099247
38tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.47584227
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.47584227
40nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37765273
41negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.37587110
42GTP biosynthetic process (GO:0006183)3.35620454
43maturation of SSU-rRNA (GO:0030490)3.31024934
44endoderm formation (GO:0001706)3.28923810
45nuclear-transcribed mRNA catabolic process (GO:0000956)3.28632347
46chaperone-mediated protein transport (GO:0072321)3.27816003
47regulation of podosome assembly (GO:0071801)3.25904763
48regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.24400012
49cellular component biogenesis (GO:0044085)3.23766443
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23419464
51water-soluble vitamin biosynthetic process (GO:0042364)3.22635895
52positive regulation of activated T cell proliferation (GO:0042104)3.21590612
53myoblast migration (GO:0051451)3.18566939
54mRNA catabolic process (GO:0006402)3.16707471
55protein complex biogenesis (GO:0070271)3.16547091
56positive regulation of defense response to virus by host (GO:0002230)3.15941892
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.13546117
58piRNA metabolic process (GO:0034587)3.09870097
59activated T cell proliferation (GO:0050798)3.02575737
60transcription elongation from RNA polymerase III promoter (GO:0006385)3.01371503
61termination of RNA polymerase III transcription (GO:0006386)3.01371503
62substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.98893883
63substrate-independent telencephalic tangential migration (GO:0021826)2.98893883
64electron transport chain (GO:0022900)2.96008971
65purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.95502391
66pyrimidine nucleotide catabolic process (GO:0006244)2.95234493
67interferon-gamma production (GO:0032609)2.94514242
68purine nucleoside triphosphate biosynthetic process (GO:0009145)2.94405691
69RNA catabolic process (GO:0006401)2.89843037
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89414765
71respiratory electron transport chain (GO:0022904)2.87676325
72regulation of chronic inflammatory response (GO:0002676)2.87201304
73UTP biosynthetic process (GO:0006228)2.83748916
74tRNA processing (GO:0008033)2.83208948
75cellular response to interferon-beta (GO:0035458)2.83032853
76ATP biosynthetic process (GO:0006754)2.82833529
77positive regulation of immunoglobulin production (GO:0002639)2.82060205
78negative regulation of T cell differentiation in thymus (GO:0033085)2.81293116
79mitochondrial respiratory chain complex I assembly (GO:0032981)2.78461552
80NADH dehydrogenase complex assembly (GO:0010257)2.78461552
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78461552
82mitochondrial respiratory chain complex assembly (GO:0033108)2.77219760
83hydrogen ion transmembrane transport (GO:1902600)2.76173956
84rRNA metabolic process (GO:0016072)2.72309453
85rRNA processing (GO:0006364)2.69274570
86positive regulation of immunoglobulin mediated immune response (GO:0002891)2.65919984
87positive regulation of B cell mediated immunity (GO:0002714)2.65919984
88regulation of mesoderm development (GO:2000380)2.61252471
89proton transport (GO:0015992)2.60693412
90positive regulation of protein homooligomerization (GO:0032464)2.60389114
91ribonucleoside triphosphate biosynthetic process (GO:0009201)2.59952619
92regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.57682510
93regulation of mitotic spindle checkpoint (GO:1903504)2.57682510
94alpha-beta T cell differentiation involved in immune response (GO:0002293)2.55656317
95alpha-beta T cell activation involved in immune response (GO:0002287)2.55656317
96T cell differentiation involved in immune response (GO:0002292)2.55656317
97hydrogen transport (GO:0006818)2.54335227
98hypothalamus development (GO:0021854)2.51694432
99somite development (GO:0061053)2.51671619
100UTP metabolic process (GO:0046051)2.51236222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.98358869
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.75920087
3EZH2_22144423_ChIP-Seq_EOC_Human3.20222412
4EST1_17652178_ChIP-ChIP_JURKAT_Human2.74148224
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.70696719
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.61445683
7VDR_22108803_ChIP-Seq_LS180_Human2.39054114
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28741843
9EWS_26573619_Chip-Seq_HEK293_Human2.23884469
10ZNF274_21170338_ChIP-Seq_K562_Hela2.23139688
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22570398
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.21608109
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11963746
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.02557089
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.02222827
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91762602
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84576837
18NOTCH1_21737748_ChIP-Seq_TLL_Human1.83897584
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.83875032
20GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.79272899
21VDR_23849224_ChIP-Seq_CD4+_Human1.78459657
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78095476
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74600079
24TP53_22573176_ChIP-Seq_HFKS_Human1.71664238
25ELK1_19687146_ChIP-ChIP_HELA_Human1.66349585
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66317621
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65176253
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.64591686
29IGF1R_20145208_ChIP-Seq_DFB_Human1.62975127
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62384141
31IRF1_19129219_ChIP-ChIP_H3396_Human1.59040079
32GBX2_23144817_ChIP-Seq_PC3_Human1.55425937
33FOXP3_21729870_ChIP-Seq_TREG_Human1.49946257
34MYC_18940864_ChIP-ChIP_HL60_Human1.43483340
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42717003
36ER_23166858_ChIP-Seq_MCF-7_Human1.40608928
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38686337
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38678572
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36423592
40P300_19829295_ChIP-Seq_ESCs_Human1.35185211
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34355541
42KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33354826
43TDRD3_21172665_ChIP-Seq_MCF-7_Human1.31862042
44CBP_20019798_ChIP-Seq_JUKART_Human1.31731258
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31731258
46FUS_26573619_Chip-Seq_HEK293_Human1.30607965
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27668151
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.27668151
49TTF2_22483619_ChIP-Seq_HELA_Human1.27122426
50TAF2_19829295_ChIP-Seq_ESCs_Human1.26122578
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.25827245
52ERA_21632823_ChIP-Seq_H3396_Human1.25517958
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24768945
54JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24463820
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24228254
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23850112
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.23149709
58CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.22604603
59GATA3_26560356_Chip-Seq_TH2_Human1.21592742
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.20325438
61EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20178529
62MYC_19829295_ChIP-Seq_ESCs_Human1.19771141
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.18104158
64NANOG_19829295_ChIP-Seq_ESCs_Human1.16798605
65SOX2_19829295_ChIP-Seq_ESCs_Human1.16798605
66NANOG_20526341_ChIP-Seq_ESCs_Human1.16669420
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16279656
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16204682
69REST_21632747_ChIP-Seq_MESCs_Mouse1.15956439
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12213296
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12023917
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.10453902
73TAF15_26573619_Chip-Seq_HEK293_Human1.10065933
74NCOR_22424771_ChIP-Seq_293T_Human1.08038500
75TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07595664
76HOXB7_26014856_ChIP-Seq_BT474_Human1.06118200
77P53_21459846_ChIP-Seq_SAOS-2_Human1.06023303
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.04729605
79TCF4_22108803_ChIP-Seq_LS180_Human1.01942265
80FOXH1_21741376_ChIP-Seq_ESCs_Human1.01888545
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00918368
82AR_20517297_ChIP-Seq_VCAP_Human0.99435453
83BCAT_22108803_ChIP-Seq_LS180_Human0.98248001
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97409420
85IRF8_21731497_ChIP-ChIP_J774_Mouse0.96394582
86SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95390454
87PRDM14_20953172_ChIP-Seq_ESCs_Human0.94473103
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.93725151
89RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93405191
90ERG_20517297_ChIP-Seq_VCAP_Human0.93226150
91SMRT_27268052_Chip-Seq_Bcells_Human0.92555217
92JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91890629
93EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91460262
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.90023639
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89981056
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.89181481
97EED_16625203_ChIP-ChIP_MESCs_Mouse0.89169615
98CTCF_20526341_ChIP-Seq_ESCs_Human0.88758119
99STAT1_20625510_ChIP-Seq_HELA_Human0.87706255
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87678972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland3.42367397
2MP0001835_abnormal_antigen_presentation3.25583129
3MP0009379_abnormal_foot_pigmentation3.19794347
4MP0008877_abnormal_DNA_methylation2.83691452
5MP0006292_abnormal_olfactory_placode2.77116982
6MP0006072_abnormal_retinal_apoptosis2.48354347
7MP0005671_abnormal_response_to2.42184807
8MP0003787_abnormal_imprinting2.32071679
9MP0008872_abnormal_physiological_respon2.19708734
10MP0001873_stomach_inflammation2.15185670
11MP0008875_abnormal_xenobiotic_pharmacok2.00365577
12MP0004142_abnormal_muscle_tone1.99195608
13MP0001968_abnormal_touch/_nociception1.94114052
14MP0002736_abnormal_nociception_after1.90573998
15MP0000604_amyloidosis1.82010506
16MP0005387_immune_system_phenotype1.79002615
17MP0001790_abnormal_immune_system1.79002615
18MP0001984_abnormal_olfaction1.72157940
19MP0003567_abnormal_fetal_cardiomyocyte1.70904736
20MP0000685_abnormal_immune_system1.70695325
21MP0002102_abnormal_ear_morphology1.69534394
22MP0002876_abnormal_thyroid_physiology1.67859812
23MP0005423_abnormal_somatic_nervous1.59263114
24MP0002272_abnormal_nervous_system1.57418775
25MP0003646_muscle_fatigue1.55635725
26MP0004742_abnormal_vestibular_system1.52379779
27MP0003878_abnormal_ear_physiology1.49873716
28MP0005377_hearing/vestibular/ear_phenot1.49873716
29MP0005551_abnormal_eye_electrophysiolog1.49109147
30MP0003183_abnormal_peptide_metabolism1.46961371
31MP0002163_abnormal_gland_morphology1.46151245
32MP0000372_irregular_coat_pigmentation1.44497262
33MP0008058_abnormal_DNA_repair1.42984571
34MP0001293_anophthalmia1.42025611
35MP0002638_abnormal_pupillary_reflex1.41916327
36MP0009046_muscle_twitch1.40721523
37MP0001502_abnormal_circadian_rhythm1.36366934
38MP0005253_abnormal_eye_physiology1.35995423
39MP0003195_calcinosis1.33056024
40MP0001853_heart_inflammation1.33012037
41MP0001986_abnormal_taste_sensitivity1.29874844
42MP0006276_abnormal_autonomic_nervous1.29524273
43MP0000569_abnormal_digit_pigmentation1.29294099
44MP0001905_abnormal_dopamine_level1.25775320
45MP0008789_abnormal_olfactory_epithelium1.25469683
46MP0001800_abnormal_humoral_immune1.22154473
47MP0001440_abnormal_grooming_behavior1.21122457
48MP0001501_abnormal_sleep_pattern1.20758665
49MP0004885_abnormal_endolymph1.19205709
50MP0000631_abnormal_neuroendocrine_gland1.17913593
51MP0002277_abnormal_respiratory_mucosa1.15348606
52MP0000049_abnormal_middle_ear1.14578241
53MP0000465_gastrointestinal_hemorrhage1.12319882
54MP0005646_abnormal_pituitary_gland1.11198446
55MP0005174_abnormal_tail_pigmentation1.09998283
56MP0009745_abnormal_behavioral_response1.07629007
57MP0001486_abnormal_startle_reflex1.06372548
58MP0000015_abnormal_ear_pigmentation1.06297322
59MP0002735_abnormal_chemical_nociception1.06095593
60MP0000566_synostosis1.03003810
61MP0009764_decreased_sensitivity_to1.01982380
62MP0003866_abnormal_defecation1.01190461
63MP0001970_abnormal_pain_threshold0.99901435
64MP0002148_abnormal_hypersensitivity_rea0.98539472
65MP0005379_endocrine/exocrine_gland_phen0.97826709
66MP0002572_abnormal_emotion/affect_behav0.97548268
67MP0005645_abnormal_hypothalamus_physiol0.95492198
68MP0002405_respiratory_system_inflammati0.94856746
69MP0002822_catalepsy0.94383365
70MP0002229_neurodegeneration0.94041306
71MP0001529_abnormal_vocalization0.93168602
72MP0001485_abnormal_pinna_reflex0.92033569
73MP0005195_abnormal_posterior_eye0.91484052
74MP0002006_tumorigenesis0.91011401
75MP0003300_gastrointestinal_ulcer0.86582408
76MP0003123_paternal_imprinting0.84286518
77MP0002138_abnormal_hepatobiliary_system0.84037310
78MP0002166_altered_tumor_susceptibility0.82639227
79MP0005000_abnormal_immune_tolerance0.81971079
80MP0002723_abnormal_immune_serum0.81892074
81MP0002067_abnormal_sensory_capabilities0.81772614
82MP0003880_abnormal_central_pattern0.81640549
83MP0001919_abnormal_reproductive_system0.81616760
84MP0001963_abnormal_hearing_physiology0.80525798
85MP0005075_abnormal_melanosome_morpholog0.80119631
86MP0009333_abnormal_splenocyte_physiolog0.80101234
87MP0005408_hypopigmentation0.80023755
88MP0002837_dystrophic_cardiac_calcinosis0.79696427
89MP0002752_abnormal_somatic_nervous0.79565969
90MP0002184_abnormal_innervation0.78968070
91MP0002420_abnormal_adaptive_immunity0.78695023
92MP0003938_abnormal_ear_development0.78588728
93MP0002095_abnormal_skin_pigmentation0.78164627
94MP0004019_abnormal_vitamin_homeostasis0.78046772
95MP0008004_abnormal_stomach_pH0.77736638
96MP0002160_abnormal_reproductive_system0.77542358
97MP0003724_increased_susceptibility_to0.76964994
98MP0005394_taste/olfaction_phenotype0.76864413
99MP0005499_abnormal_olfactory_system0.76864413
100MP0001819_abnormal_immune_cell0.76804632

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.71240871
2Congenital stationary night blindness (HP:0007642)4.44833189
3Visual hallucinations (HP:0002367)4.26157177
4Stomatitis (HP:0010280)4.05278694
5Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.93669178
6Increased neuronal autofluorescent lipopigment (HP:0002074)3.89801405
7Abnormality of midbrain morphology (HP:0002418)3.80090075
8Molar tooth sign on MRI (HP:0002419)3.80090075
9Abnormality of cells of the erythroid lineage (HP:0012130)3.79169252
10Asplenia (HP:0001746)3.67925091
113-Methylglutaconic aciduria (HP:0003535)3.67320535
12Aplasia/Hypoplasia of the spleen (HP:0010451)3.64507938
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.50350623
14Macrocytic anemia (HP:0001972)3.40841689
15Pancreatic cysts (HP:0001737)3.26389870
16Pancreatic fibrosis (HP:0100732)3.25659091
17Abnormal biliary tract physiology (HP:0012439)3.22846815
18Bile duct proliferation (HP:0001408)3.22846815
19Abnormal rod and cone electroretinograms (HP:0008323)3.10452689
20Acute necrotizing encephalopathy (HP:0006965)2.99908894
21Increased cerebral lipofuscin (HP:0011813)2.94125719
22Parakeratosis (HP:0001036)2.92956384
23Renal cortical cysts (HP:0000803)2.90481116
24Nephronophthisis (HP:0000090)2.85987976
25Stenosis of the external auditory canal (HP:0000402)2.83623914
26IgG deficiency (HP:0004315)2.80331180
27Increased IgM level (HP:0003496)2.76882632
28Pallor (HP:0000980)2.72336395
29Abnormality of the renal cortex (HP:0011035)2.69097962
30Abnormal pupillary function (HP:0007686)2.68624941
31Congenital, generalized hypertrichosis (HP:0004540)2.64672793
32Mitochondrial inheritance (HP:0001427)2.60698000
33Acute encephalopathy (HP:0006846)2.58989061
34Abnormality of alanine metabolism (HP:0010916)2.57392760
35Hyperalaninemia (HP:0003348)2.57392760
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.57392760
37Abnormal mitochondria in muscle tissue (HP:0008316)2.56539003
38Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.51003191
39Hepatocellular necrosis (HP:0001404)2.50386801
40Abnormality of the phalanges of the 5th finger (HP:0004213)2.50198189
41Supernumerary spleens (HP:0009799)2.50180621
42Sclerocornea (HP:0000647)2.49090083
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.48896611
44Absent/shortened dynein arms (HP:0200106)2.48896611
45Abnormal ciliary motility (HP:0012262)2.48798445
46Absent thumb (HP:0009777)2.48774631
47True hermaphroditism (HP:0010459)2.47813620
48Adrenal hypoplasia (HP:0000835)2.42559088
49Hypoplasia of the ulna (HP:0003022)2.42019380
50Progressive macrocephaly (HP:0004481)2.40439972
51Rib fusion (HP:0000902)2.37532288
52Symphalangism affecting the phalanges of the hand (HP:0009773)2.36645678
53Abnormality of the renal medulla (HP:0100957)2.33779168
54Confusion (HP:0001289)2.32856628
55Testicular atrophy (HP:0000029)2.32491024
56Abnormal number of erythroid precursors (HP:0012131)2.30819426
57Autoimmune thrombocytopenia (HP:0001973)2.27948985
58Aplasia/Hypoplasia of the ulna (HP:0006495)2.27324517
59Limb dystonia (HP:0002451)2.27290788
60Increased CSF lactate (HP:0002490)2.26991091
61Abolished electroretinogram (ERG) (HP:0000550)2.26184790
62Autoimmune hemolytic anemia (HP:0001890)2.25530313
63Abnormality of the renal collecting system (HP:0004742)2.23426705
64Hepatic necrosis (HP:0002605)2.21236635
65Abnormal respiratory motile cilium morphology (HP:0005938)2.21037299
66Abnormal respiratory epithelium morphology (HP:0012253)2.21037299
67Pendular nystagmus (HP:0012043)2.14575436
68Optic disc pallor (HP:0000543)2.12426776
69Elevated erythrocyte sedimentation rate (HP:0003565)2.08428477
70Medial flaring of the eyebrow (HP:0010747)2.05161030
71Cystic liver disease (HP:0006706)2.00402463
72Hypoplasia of the radius (HP:0002984)1.99493506
73Abnormality of T cell physiology (HP:0011840)1.99449064
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99170599
75Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99170599
76Abnormal respiratory motile cilium physiology (HP:0012261)1.98517815
77Aplasia/Hypoplasia of the uvula (HP:0010293)1.98437193
78Septo-optic dysplasia (HP:0100842)1.97896879
79Forearm undergrowth (HP:0009821)1.95399008
80Duplicated collecting system (HP:0000081)1.94066672
81Type II lissencephaly (HP:0007260)1.93702349
82Abnormality of the pons (HP:0007361)1.92992287
83Abnormality of B cell number (HP:0010975)1.92047484
84Bifid tongue (HP:0010297)1.87672923
85Increased serum lactate (HP:0002151)1.87118356
86Anophthalmia (HP:0000528)1.84731062
87Tachypnea (HP:0002789)1.83462762
88Cerebral edema (HP:0002181)1.81974270
89Methylmalonic acidemia (HP:0002912)1.81400577
90Neutropenia (HP:0001875)1.75058537
91Triphalangeal thumb (HP:0001199)1.74500509
92Pancytopenia (HP:0001876)1.73381449
93Aplasia/Hypoplasia of the tongue (HP:0010295)1.72949339
94Horseshoe kidney (HP:0000085)1.71190612
95Large for gestational age (HP:0001520)1.70951675
96Abnormality of the ileum (HP:0001549)1.70755201
97Hypomagnesemia (HP:0002917)1.70522045
98Prostate neoplasm (HP:0100787)1.69801313
99Polydipsia (HP:0001959)1.68227535
100Abnormal drinking behavior (HP:0030082)1.68227535

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.67687996
2ADRBK24.34006857
3GRK13.87992056
4MAP4K13.02249904
5WNK42.74979707
6MAP3K122.59439362
7NME12.36593310
8ZAK2.12034730
9PIK3CA2.00788465
10FRK1.95765664
11AKT31.94169657
12EIF2AK11.87680786
13DYRK21.86105655
14SCYL21.83537337
15NUAK11.74035824
16TLK11.51109058
17PLK41.49052990
18WNK31.46835659
19MAP4K21.44848850
20IKBKB1.43029103
21PINK11.35159820
22MAP3K41.33847316
23CASK1.22490781
24TEC1.18906424
25BCKDK1.17795497
26NME21.15698161
27STK391.14372678
28LRRK21.09019983
29MYLK1.08062811
30IKBKE1.03835482
31NEK11.03551176
32ADRBK10.99500372
33BMPR1B0.98639291
34PNCK0.97560693
35ITK0.95637546
36TAOK30.92952674
37WNK10.86775455
38TNIK0.86658485
39MAP2K20.84192236
40MAP3K110.83057543
41BMPR20.82924166
42INSRR0.82487820
43PAK30.80142876
44SYK0.78803543
45VRK20.76924900
46TIE10.75913506
47PDK20.74017786
48BTK0.73858306
49CAMKK20.71202435
50CDK190.69213010
51KIT0.68686198
52BRSK20.67899350
53DAPK20.66994683
54SGK2230.66503133
55SGK4940.66503133
56CAMK2D0.66409440
57STK160.65535997
58GRK50.65098743
59DYRK30.64242045
60CSNK2A20.62912011
61MAP2K70.62505093
62VRK10.61996862
63CAMK1D0.60886651
64FES0.60323744
65PRKCG0.58102296
66LCK0.55996684
67RPS6KA40.55120390
68CAMK10.53257302
69MAP3K140.53213035
70LYN0.52953369
71PBK0.52900415
72PRKCQ0.52409204
73GRK70.52248448
74DAPK30.52043690
75TRIM280.51824049
76RPS6KA50.51810887
77OBSCN0.51474650
78PHKG10.51290088
79PHKG20.51290088
80CAMK2G0.49665517
81WEE10.48345509
82CAMK2A0.47957116
83CSNK1A10.47697482
84OXSR10.47568654
85PRKACA0.47243802
86PASK0.46097633
87TSSK60.45279127
88MAP2K60.44665267
89PLK20.44187806
90IGF1R0.43468695
91DYRK1A0.43313624
92MKNK20.42381111
93TGFBR10.39304314
94DAPK10.39035386
95SGK20.38992104
96RPS6KA60.37064392
97PRKD30.36956191
98PRKCE0.36384916
99CSNK1G10.34640597
100CSNK2A10.34502852

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.28359503
2Asthma_Homo sapiens_hsa053103.53115091
3Oxidative phosphorylation_Homo sapiens_hsa001903.29836610
4Allograft rejection_Homo sapiens_hsa053303.27512631
5Autoimmune thyroid disease_Homo sapiens_hsa053203.04531702
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.98887579
7Proteasome_Homo sapiens_hsa030502.57501166
8Parkinsons disease_Homo sapiens_hsa050122.47425147
9RNA polymerase_Homo sapiens_hsa030202.39330173
10Protein export_Homo sapiens_hsa030602.30401768
11Cardiac muscle contraction_Homo sapiens_hsa042602.10429644
12Graft-versus-host disease_Homo sapiens_hsa053321.97054009
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94655201
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89693446
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85784254
16Type I diabetes mellitus_Homo sapiens_hsa049401.81820088
17Huntingtons disease_Homo sapiens_hsa050161.76350868
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72478671
19RNA degradation_Homo sapiens_hsa030181.66989282
20Linoleic acid metabolism_Homo sapiens_hsa005911.63783017
21Alzheimers disease_Homo sapiens_hsa050101.61510502
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59624793
23Phototransduction_Homo sapiens_hsa047441.55671490
24Basal transcription factors_Homo sapiens_hsa030221.43016731
25Homologous recombination_Homo sapiens_hsa034401.40570631
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31432110
27Primary immunodeficiency_Homo sapiens_hsa053401.27110275
28Mismatch repair_Homo sapiens_hsa034301.25629480
29Fanconi anemia pathway_Homo sapiens_hsa034601.20030117
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19747670
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19196160
32Nicotine addiction_Homo sapiens_hsa050331.18306778
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15479771
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15152153
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15129566
36Nucleotide excision repair_Homo sapiens_hsa034201.12133086
37Pyrimidine metabolism_Homo sapiens_hsa002401.10798467
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08913756
39Nitrogen metabolism_Homo sapiens_hsa009101.08676572
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04928799
41Caffeine metabolism_Homo sapiens_hsa002321.03804169
42Arachidonic acid metabolism_Homo sapiens_hsa005901.01723057
43Rheumatoid arthritis_Homo sapiens_hsa053231.01675570
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.00373223
45Vitamin B6 metabolism_Homo sapiens_hsa007500.94798799
46Spliceosome_Homo sapiens_hsa030400.93297052
47T cell receptor signaling pathway_Homo sapiens_hsa046600.92904322
48RNA transport_Homo sapiens_hsa030130.90698539
49Tryptophan metabolism_Homo sapiens_hsa003800.88420623
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87475076
51Collecting duct acid secretion_Homo sapiens_hsa049660.84779698
52Hematopoietic cell lineage_Homo sapiens_hsa046400.82181231
53Fat digestion and absorption_Homo sapiens_hsa049750.76853655
54Regulation of autophagy_Homo sapiens_hsa041400.75988590
55Taste transduction_Homo sapiens_hsa047420.70947879
56Purine metabolism_Homo sapiens_hsa002300.70354058
57Olfactory transduction_Homo sapiens_hsa047400.69750722
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68888272
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.68799930
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67115958
61Chemical carcinogenesis_Homo sapiens_hsa052040.65656907
62Ether lipid metabolism_Homo sapiens_hsa005650.64636496
63Propanoate metabolism_Homo sapiens_hsa006400.64159350
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63015695
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.57610489
66Morphine addiction_Homo sapiens_hsa050320.57589028
67Antigen processing and presentation_Homo sapiens_hsa046120.56224240
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.53864972
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52259168
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50885048
71Retinol metabolism_Homo sapiens_hsa008300.50786720
72One carbon pool by folate_Homo sapiens_hsa006700.50055518
73Peroxisome_Homo sapiens_hsa041460.48364636
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44340495
75DNA replication_Homo sapiens_hsa030300.43470100
76Metabolic pathways_Homo sapiens_hsa011000.43166821
77Ovarian steroidogenesis_Homo sapiens_hsa049130.42108296
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41982630
79Fatty acid biosynthesis_Homo sapiens_hsa000610.40787548
80GABAergic synapse_Homo sapiens_hsa047270.39654415
81Pyruvate metabolism_Homo sapiens_hsa006200.37585116
82Systemic lupus erythematosus_Homo sapiens_hsa053220.36610252
83Serotonergic synapse_Homo sapiens_hsa047260.35926779
84Insulin secretion_Homo sapiens_hsa049110.35528215
85Selenocompound metabolism_Homo sapiens_hsa004500.34835808
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.32807563
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28744194
88Glycerolipid metabolism_Homo sapiens_hsa005610.27414902
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27172810
90Vitamin digestion and absorption_Homo sapiens_hsa049770.24647521
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24405441
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24138163
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.23761348
94Steroid biosynthesis_Homo sapiens_hsa001000.22973809
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22883366
96Sulfur metabolism_Homo sapiens_hsa009200.21432940
97Viral myocarditis_Homo sapiens_hsa054160.20089158
98Measles_Homo sapiens_hsa051620.19056223
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.18525709
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.16669756

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