ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.60866754
2	cytidine deamination (GO:0009972)	5.47949712
3	cytidine metabolic process (GO:0046087)	5.47949712
4	cytidine catabolic process (GO:0006216)	5.47949712
5	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.59067765
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.45238501
7	positive regulation of defense response to virus by host (GO:0002230)	4.36953946
8	regulation of regulatory T cell differentiation (GO:0045589)	4.25268243
9	ribosomal small subunit assembly (GO:0000028)	3.99927485
10	rRNA catabolic process (GO:0016075)	3.81416994
11	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.81082476
12	behavioral response to nicotine (GO:0035095)	3.75826584
13	meiotic chromosome segregation (GO:0045132)	3.75071163
14	water-soluble vitamin biosynthetic process (GO:0042364)	3.60770878
15	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.49349410
16	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.37355856
17	L-fucose catabolic process (GO:0042355)	3.32267718
18	fucose catabolic process (GO:0019317)	3.32267718
19	L-fucose metabolic process (GO:0042354)	3.32267718
20	negative regulation of T cell differentiation in thymus (GO:0033085)	3.31896169
21	protein K11-linked deubiquitination (GO:0035871)	3.27491502
22	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.22382042
23	platelet dense granule organization (GO:0060155)	3.22160696
24	interferon-gamma production (GO:0032609)	3.22063968
25	piRNA metabolic process (GO:0034587)	3.18523345
26	rRNA methylation (GO:0031167)	3.16778604
27	cellular response to interleukin-15 (GO:0071350)	3.16771210
28	kynurenine metabolic process (GO:0070189)	3.16163717
29	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.14078491
30	regulation of isotype switching to IgG isotypes (GO:0048302)	3.11569391
31	rRNA modification (GO:0000154)	3.07562628
32	tryptophan catabolic process (GO:0006569)	3.04201491
33	indole-containing compound catabolic process (GO:0042436)	3.04201491
34	indolalkylamine catabolic process (GO:0046218)	3.04201491
35	response to pheromone (GO:0019236)	2.99251865
36	ATP synthesis coupled proton transport (GO:0015986)	2.98384181
37	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.98384181
38	auditory receptor cell stereocilium organization (GO:0060088)	2.97672950
39	regulation of meiosis I (GO:0060631)	2.96061077
40	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.89830659
41	regulation of immunoglobulin secretion (GO:0051023)	2.89397803
42	positive regulation of cell fate commitment (GO:0010455)	2.88830880
43	positive regulation of interleukin-17 production (GO:0032740)	2.86799285
44	protein complex biogenesis (GO:0070271)	2.83879288
45	negative T cell selection (GO:0043383)	2.81855412
46	cellular response to exogenous dsRNA (GO:0071360)	2.81774138
47	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.81754972
48	protein-cofactor linkage (GO:0018065)	2.81271248
49	viral transcription (GO:0019083)	2.79047023
50	DNA demethylation (GO:0080111)	2.78089841
51	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.76710998
52	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.76346666
53	negative regulation of B cell apoptotic process (GO:0002903)	2.75998253
54	positive regulation of fatty acid transport (GO:2000193)	2.74503339
55	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.73115241
56	reciprocal meiotic recombination (GO:0007131)	2.71854535
57	reciprocal DNA recombination (GO:0035825)	2.71854535
58	translational termination (GO:0006415)	2.70405628
59	positive T cell selection (GO:0043368)	2.65976706
60	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.65045702
61	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.65045702
62	protein neddylation (GO:0045116)	2.64774353
63	adaptation of signaling pathway (GO:0023058)	2.64202557
64	regulation of memory T cell differentiation (GO:0043380)	2.61040155
65	tachykinin receptor signaling pathway (GO:0007217)	2.60367324
66	positive regulation of interleukin-8 secretion (GO:2000484)	2.60188926
67	axoneme assembly (GO:0035082)	2.59267140
68	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.59018311
69	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.57927791
70	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.57443352
71	NADH dehydrogenase complex assembly (GO:0010257)	2.57443352
72	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.57443352
73	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.56728187
74	pseudouridine synthesis (GO:0001522)	2.55061514
75	respiratory chain complex IV assembly (GO:0008535)	2.54878680
76	regulation of T cell mediated cytotoxicity (GO:0001914)	2.53973894
77	transmission of nerve impulse (GO:0019226)	2.53734143
78	positive regulation of T-helper 1 type immune response (GO:0002827)	2.53171572
79	translational elongation (GO:0006414)	2.53150691
80	mitochondrial respiratory chain complex assembly (GO:0033108)	2.52067478
81	DNA dealkylation (GO:0035510)	2.51408161
82	regulation of defense response to virus by host (GO:0050691)	2.50992881
83	positive regulation of digestive system process (GO:0060456)	2.50524950
84	cellular ketone body metabolic process (GO:0046950)	2.49326060
85	regulation of interleukin-8 secretion (GO:2000482)	2.49325345
86	cotranslational protein targeting to membrane (GO:0006613)	2.49067498
87	indolalkylamine metabolic process (GO:0006586)	2.47412326
88	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.45762017
89	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.45630008
90	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.45071735
91	protein targeting to ER (GO:0045047)	2.44442744
92	positive regulation of activated T cell proliferation (GO:0042104)	2.43478852
93	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.42944961
94	positive regulation of prostaglandin secretion (GO:0032308)	2.42005316
95	rhodopsin mediated signaling pathway (GO:0016056)	2.41615545
96	mast cell activation (GO:0045576)	2.41578675
97	C-terminal protein lipidation (GO:0006501)	2.41387256
98	DNA double-strand break processing (GO:0000729)	2.38086426
99	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.37707815
100	electron transport chain (GO:0022900)	2.37494627

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.47502002
2	VDR_22108803_ChIP-Seq_LS180_Human	2.86222572
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.65443147
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.60316381
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.56078695
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.43329886
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.38642915
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.35965587
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.35889625
10	EWS_26573619_Chip-Seq_HEK293_Human	2.35857170
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.28049001
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.23741512
13	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.16722339
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.12555568
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.00711808
16	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.00574638
17	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.86213835
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.85235395
19	GBX2_23144817_ChIP-Seq_PC3_Human	1.85027930
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.83784001
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.82624024
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.82521727
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.80021785
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.79723212
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.79495413
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.78917312
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.78796992
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.76659174
29	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.73354322
30	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.73354322
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.71801103
32	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.70370159
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.68946177
34	P300_19829295_ChIP-Seq_ESCs_Human	1.60133817
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.58213822
36	FUS_26573619_Chip-Seq_HEK293_Human	1.57783674
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.56809065
38	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.50697198
39	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.45820636
40	AR_20517297_ChIP-Seq_VCAP_Human	1.44357204
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43629137
42	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.41707305
43	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.40728451
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.37113913
45	FOXP3_21729870_ChIP-Seq_TREG_Human	1.34255555
46	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.33369522
47	NANOG_20526341_ChIP-Seq_ESCs_Human	1.32564246
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31383258
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31383258
50	GATA3_26560356_Chip-Seq_TH2_Human	1.31294428
51	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.31130620
52	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.27629371
53	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.27261626
54	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.26233252
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.26125203
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.25835234
57	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25835234
58	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.25727181
59	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25632966
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.23631153
61	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.22689367
62	NCOR_22424771_ChIP-Seq_293T_Human	1.21987291
63	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19940266
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17868754
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17436428
66	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16418486
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.15655633
68	MYC_19829295_ChIP-Seq_ESCs_Human	1.15052446
69	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14722691
70	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12998597
71	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.12413212
72	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.11956359
73	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.11094731
74	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11013001
75	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.10226126
76	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.10197995
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.10052261
78	TAF2_19829295_ChIP-Seq_ESCs_Human	1.09932666
79	ELK1_19687146_ChIP-ChIP_HELA_Human	1.09906395
80	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.09547277
81	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08174945
82	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.07740934
83	TCF4_23295773_ChIP-Seq_U87_Human	1.07671985
84	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06786176
85	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.06786176
86	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.05585382
87	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.05492273
88	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.04010084
89	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.03305477
90	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.03001885
91	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01275409
92	RBPJ_21746931_ChIP-Seq_IB4_Human	1.01128988
93	ETV1_20927104_ChIP-Seq_GIST48_Human	1.00074570
94	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.99813154
95	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99399097
96	CDX2_22108803_ChIP-Seq_LS180_Human	0.96364430
97	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.96330465
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.95542879
99	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95353668
100	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.94531684

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.46346705
2	MP0001835_abnormal_antigen_presentation	2.84977508
3	MP0003646_muscle_fatigue	2.79365503
4	MP0006292_abnormal_olfactory_placode	2.59862204
5	MP0005646_abnormal_pituitary_gland	2.30610743
6	MP0004147_increased_porphyrin_level	2.30543400
7	MP0006072_abnormal_retinal_apoptosis	2.29936769
8	MP0005377_hearing/vestibular/ear_phenot	2.25520964
9	MP0003878_abnormal_ear_physiology	2.25520964
10	MP0003011_delayed_dark_adaptation	2.09290110
11	MP0005551_abnormal_eye_electrophysiolog	2.05052338
12	MP0002102_abnormal_ear_morphology	2.03989792
13	MP0008872_abnormal_physiological_respon	2.01612336
14	MP0009785_altered_susceptibility_to	1.98042813
15	MP0008877_abnormal_DNA_methylation	1.86639253
16	MP0004142_abnormal_muscle_tone	1.86273110
17	MP0002876_abnormal_thyroid_physiology	1.82672514
18	MP0002163_abnormal_gland_morphology	1.79757017
19	MP0001986_abnormal_taste_sensitivity	1.78665093
20	MP0002277_abnormal_respiratory_mucosa	1.76907065
21	MP0002148_abnormal_hypersensitivity_rea	1.72942728
22	MP0003195_calcinosis	1.71336580
23	MP0001800_abnormal_humoral_immune	1.68923686
24	MP0009764_decreased_sensitivity_to	1.62617544
25	MP0004145_abnormal_muscle_electrophysio	1.60015535
26	MP0008875_abnormal_xenobiotic_pharmacok	1.59591714
27	MP0004885_abnormal_endolymph	1.59433183
28	MP0009745_abnormal_behavioral_response	1.57720959
29	MP0000685_abnormal_immune_system	1.57261925
30	MP0005645_abnormal_hypothalamus_physiol	1.56252915
31	MP0002638_abnormal_pupillary_reflex	1.52848072
32	MP0001968_abnormal_touch/_nociception	1.52148525
33	MP0002837_dystrophic_cardiac_calcinosis	1.50903751
34	MP0002723_abnormal_immune_serum	1.47518549
35	MP0002272_abnormal_nervous_system	1.44821268
36	MP0005253_abnormal_eye_physiology	1.44756330
37	MP0000631_abnormal_neuroendocrine_gland	1.43700573
38	MP0005085_abnormal_gallbladder_physiolo	1.41389987
39	MP0005387_immune_system_phenotype	1.40594682
40	MP0001790_abnormal_immune_system	1.40594682
41	MP0005310_abnormal_salivary_gland	1.36207635
42	MP0003763_abnormal_thymus_physiology	1.33387395
43	MP0005000_abnormal_immune_tolerance	1.31667546
44	MP0002420_abnormal_adaptive_immunity	1.25836277
45	MP0002693_abnormal_pancreas_physiology	1.24840749
46	MP0002138_abnormal_hepatobiliary_system	1.23442477
47	MP0005075_abnormal_melanosome_morpholog	1.22786769
48	MP0005410_abnormal_fertilization	1.22726106
49	MP0004742_abnormal_vestibular_system	1.22710011
50	MP0001819_abnormal_immune_cell	1.20651655
51	MP0005389_reproductive_system_phenotype	1.20137563
52	MP0009379_abnormal_foot_pigmentation	1.19801034
53	MP0005025_abnormal_response_to	1.19709060
54	MP0003866_abnormal_defecation	1.18675488
55	MP0002452_abnormal_antigen_presenting	1.17533479
56	MP0001485_abnormal_pinna_reflex	1.17488256
57	MP0000372_irregular_coat_pigmentation	1.17050840
58	MP0004484_altered_response_of	1.15658615
59	MP0001919_abnormal_reproductive_system	1.11119586
60	MP0009046_muscle_twitch	1.11114749
61	MP0002736_abnormal_nociception_after	1.10425145
62	MP0003786_premature_aging	1.09819206
63	MP0003787_abnormal_imprinting	1.09522214
64	MP0002733_abnormal_thermal_nociception	1.06578546
65	MP0005084_abnormal_gallbladder_morpholo	1.05297391
66	MP0001764_abnormal_homeostasis	1.03246133
67	MP0002095_abnormal_skin_pigmentation	1.02878332
68	MP0000427_abnormal_hair_cycle	1.02843547
69	MP0010155_abnormal_intestine_physiology	1.00425207
70	MP0001970_abnormal_pain_threshold	1.00337111
71	MP0001905_abnormal_dopamine_level	0.96970480
72	MP0004043_abnormal_pH_regulation	0.95243421
73	MP0005332_abnormal_amino_acid	0.94602327
74	MP0001501_abnormal_sleep_pattern	0.92685630
75	MP0003633_abnormal_nervous_system	0.92650393
76	MP0003880_abnormal_central_pattern	0.91913036
77	MP0001845_abnormal_inflammatory_respons	0.89779902
78	MP0001486_abnormal_startle_reflex	0.89762513
79	MP0003806_abnormal_nucleotide_metabolis	0.89170850
80	MP0000716_abnormal_immune_system	0.89098209
81	MP0003718_maternal_effect	0.88702108
82	MP0003045_fibrosis	0.86418426
83	MP0002160_abnormal_reproductive_system	0.85310214
84	MP0002064_seizures	0.84519124
85	MP0009333_abnormal_splenocyte_physiolog	0.84238135
86	MP0008789_abnormal_olfactory_epithelium	0.82739565
87	MP0001873_stomach_inflammation	0.82518906
88	MP0002405_respiratory_system_inflammati	0.81276215
89	MP0001963_abnormal_hearing_physiology	0.80005034
90	MP0005379_endocrine/exocrine_gland_phen	0.78236247
91	MP0002938_white_spotting	0.77309035
92	MP0005195_abnormal_posterior_eye	0.76997591
93	MP0000689_abnormal_spleen_morphology	0.76917236
94	MP0001853_heart_inflammation	0.76543357
95	MP0009643_abnormal_urine_homeostasis	0.76470232
96	MP0002234_abnormal_pharynx_morphology	0.75714931
97	MP0005167_abnormal_blood-brain_barrier	0.75312651
98	MP0005636_abnormal_mineral_homeostasis	0.73935210
99	MP0001119_abnormal_female_reproductive	0.73914569
100	MP0005083_abnormal_biliary_tract	0.70932417

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	5.06545243
2	Pancreatic cysts (HP:0001737)	4.03011991
3	Congenital stationary night blindness (HP:0007642)	4.01523916
4	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.77911903
5	IgG deficiency (HP:0004315)	3.61581640
6	3-Methylglutaconic aciduria (HP:0003535)	3.60485706
7	Abnormal rod and cone electroretinograms (HP:0008323)	3.51519046
8	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.48232756
9	Molar tooth sign on MRI (HP:0002419)	3.42106906
10	Abnormality of midbrain morphology (HP:0002418)	3.42106906
11	Pancreatic fibrosis (HP:0100732)	3.36385996
12	Nephronophthisis (HP:0000090)	3.28405768
13	True hermaphroditism (HP:0010459)	3.24183591
14	Severe combined immunodeficiency (HP:0004430)	3.14972332
15	Aplastic anemia (HP:0001915)	3.13183973
16	Elevated erythrocyte sedimentation rate (HP:0003565)	3.12273279
17	Acute necrotizing encephalopathy (HP:0006965)	3.07621586
18	Mitochondrial inheritance (HP:0001427)	2.94867098
19	Chronic bronchitis (HP:0004469)	2.73614760
20	Type II lissencephaly (HP:0007260)	2.71313475
21	Medial flaring of the eyebrow (HP:0010747)	2.67247644
22	Abnormality of the renal cortex (HP:0011035)	2.66817871
23	Progressive macrocephaly (HP:0004481)	2.66163428
24	Abnormal mitochondria in muscle tissue (HP:0008316)	2.65037246
25	Tubular atrophy (HP:0000092)	2.62412449
26	Attenuation of retinal blood vessels (HP:0007843)	2.60775965
27	Thyroiditis (HP:0100646)	2.59713237
28	Congenital, generalized hypertrichosis (HP:0004540)	2.57331563
29	Pigmentary retinal degeneration (HP:0001146)	2.55222791
30	Increased CSF lactate (HP:0002490)	2.54679911
31	Hepatocellular necrosis (HP:0001404)	2.50486684
32	Abnormality of T cell number (HP:0011839)	2.48268711
33	Hypoproteinemia (HP:0003075)	2.48145652
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.47312637
35	Abnormality of alanine metabolism (HP:0010916)	2.47312637
36	Hyperalaninemia (HP:0003348)	2.47312637
37	Abnormality of the renal medulla (HP:0100957)	2.46648400
38	T lymphocytopenia (HP:0005403)	2.45581417
39	Acute encephalopathy (HP:0006846)	2.44040480
40	Combined immunodeficiency (HP:0005387)	2.42579439
41	Abnormality of T cells (HP:0002843)	2.42039608
42	Renal cortical cysts (HP:0000803)	2.42021427
43	Chronic hepatic failure (HP:0100626)	2.32031896
44	Increased IgM level (HP:0003496)	2.31195398
45	Hepatic necrosis (HP:0002605)	2.31158393
46	Hypoplasia of the pons (HP:0012110)	2.27388637
47	Lipid accumulation in hepatocytes (HP:0006561)	2.22700264
48	Abnormal drinking behavior (HP:0030082)	2.22613565
49	Polydipsia (HP:0001959)	2.22613565
50	Cystic liver disease (HP:0006706)	2.21456504
51	Thyroid-stimulating hormone excess (HP:0002925)	2.15291481
52	Methylmalonic acidemia (HP:0002912)	2.15132207
53	Increased hepatocellular lipid droplets (HP:0006565)	2.14276004
54	Optic disc pallor (HP:0000543)	2.10502604
55	Decreased central vision (HP:0007663)	2.10500514
56	Abnormality of T cell physiology (HP:0011840)	2.10182367
57	Abnormality of cells of the erythroid lineage (HP:0012130)	2.09681191
58	Abnormal respiratory motile cilium physiology (HP:0012261)	2.09260409
59	Pendular nystagmus (HP:0012043)	2.07569206
60	Congenital hepatic fibrosis (HP:0002612)	2.07222296
61	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.07016626
62	Asplenia (HP:0001746)	2.06725170
63	Cerebellar dysplasia (HP:0007033)	2.06150403
64	Abolished electroretinogram (ERG) (HP:0000550)	2.04109285
65	Abnormality of DNA repair (HP:0003254)	2.00973129
66	Sclerocornea (HP:0000647)	2.00621477
67	Abnormality of the pons (HP:0007361)	1.99822692
68	Bronchitis (HP:0012387)	1.96455887
69	Nephrogenic diabetes insipidus (HP:0009806)	1.96410763
70	Congenital primary aphakia (HP:0007707)	1.95697431
71	Bony spicule pigmentary retinopathy (HP:0007737)	1.95531682
72	Gait imbalance (HP:0002141)	1.95396528
73	Abnormality of B cell number (HP:0010975)	1.92694695
74	Increased serum lactate (HP:0002151)	1.90887243
75	Aplasia/hypoplasia of the uterus (HP:0008684)	1.89300515
76	Constricted visual fields (HP:0001133)	1.87594786
77	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.87029822
78	Retrobulbar optic neuritis (HP:0100654)	1.85802555
79	Optic neuritis (HP:0100653)	1.85802555
80	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.84398049
81	Autoimmune hemolytic anemia (HP:0001890)	1.84044154
82	Optic nerve hypoplasia (HP:0000609)	1.83063963
83	Decreased circulating renin level (HP:0003351)	1.82100066
84	Abnormality of eosinophils (HP:0001879)	1.81898339
85	Recurrent cutaneous fungal infections (HP:0011370)	1.81314135
86	Chronic mucocutaneous candidiasis (HP:0002728)	1.81314135
87	Conical tooth (HP:0000698)	1.78581697
88	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.78426729
89	Abnormal number of erythroid precursors (HP:0012131)	1.77983367
90	Neutropenia (HP:0001875)	1.77770565
91	Abnormal biliary tract physiology (HP:0012439)	1.76461305
92	Bile duct proliferation (HP:0001408)	1.76461305
93	Renal Fanconi syndrome (HP:0001994)	1.75992312
94	Cerebral edema (HP:0002181)	1.73894148
95	Confusion (HP:0001289)	1.72797450
96	Male pseudohermaphroditism (HP:0000037)	1.71000295
97	Furrowed tongue (HP:0000221)	1.70885519
98	Ketosis (HP:0001946)	1.69687152
99	Rhinitis (HP:0012384)	1.69607626
100	Colon cancer (HP:0003003)	1.69276163

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	6.06422386
2	FRK	3.72614752
3	TESK2	3.52488228
4	TAOK3	2.99847761
5	ZAK	2.71831860
6	BLK	2.70698996
7	MAP4K2	2.56318707
8	GRK1	2.53516126
9	ADRBK2	2.29742586
10	NUAK1	2.22139754
11	PASK	2.07061296
12	KDR	2.06430005
13	WNK4	2.03362109
14	MAP4K1	1.77875596
15	ITK	1.69526308
16	CDK19	1.62138945
17	MUSK	1.61608633
18	MST4	1.60748488
19	TLK1	1.55476432
20	BMPR1B	1.43656232
21	MAP3K12	1.27849180
22	WNK3	1.25165678
23	MAP3K9	1.23524321
24	TEC	1.21502547
25	IKBKB	1.20806622
26	DYRK2	1.20465916
27	BUB1	1.12919471
28	PINK1	1.12061764
29	PRKCQ	1.10541015
30	FES	1.10301071
31	CAMKK2	1.09384902
32	MAP2K6	1.08846619
33	STK39	1.07942130
34	OXSR1	1.05518272
35	MAP2K7	0.99067426
36	NEK1	0.97289720
37	BCKDK	0.97283305
38	INSRR	0.91991953
39	MAPK13	0.90632980
40	RPS6KA4	0.88408807
41	SCYL2	0.87278524
42	VRK1	0.79316894
43	VRK2	0.79012934
44	PIK3CA	0.78908683
45	PLK4	0.78029250
46	ADRBK1	0.77953011
47	STK38L	0.76860455
48	LYN	0.76172117
49	STK3	0.72531672
50	CAMKK1	0.71706992
51	TYRO3	0.69476461
52	SYK	0.68480597
53	RPS6KA5	0.67812469
54	IKBKE	0.67697657
55	TIE1	0.64784202
56	KIT	0.64508944
57	MAPKAPK3	0.63748611
58	LCK	0.63730722
59	CSK	0.57913937
60	MAP3K4	0.57740810
61	TNK2	0.57456741
62	PIK3CG	0.55867576
63	TAF1	0.54110939
64	PDK1	0.52698750
65	BTK	0.51275482
66	GRK7	0.51071217
67	PRKCE	0.50647592
68	LIMK1	0.49995782
69	MAPKAPK5	0.49215885
70	IGF1R	0.48967926
71	EPHA4	0.48007776
72	CHUK	0.47212281
73	GRK5	0.46427919
74	PRKCG	0.45725017
75	STK24	0.45654861
76	PAK3	0.43178845
77	NME1	0.42616520
78	PTK2B	0.42454563
79	MARK3	0.42444639
80	OBSCN	0.40309660
81	DAPK1	0.39683851
82	MATK	0.38921349
83	CAMK2A	0.37104414
84	PRKACA	0.36804942
85	RPS6KA6	0.35941955
86	CAMK1	0.34542043
87	PRKCA	0.33980073
88	ZAP70	0.33895050
89	DAPK2	0.33529101
90	MYLK	0.32286724
91	ROCK1	0.32150177
92	PLK3	0.31448246
93	EIF2AK3	0.31263915
94	BMPR2	0.31084635
95	ATR	0.30767616
96	PIM1	0.29092947
97	CSNK2A2	0.28965074
98	HIPK2	0.27909978
99	PHKG2	0.27859955
100	PHKG1	0.27859955

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	3.57899514
2	Ribosome_Homo sapiens_hsa03010	2.93893287
3	Asthma_Homo sapiens_hsa05310	2.84973413
4	Allograft rejection_Homo sapiens_hsa05330	2.81697933
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.81395504
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.71958911
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.46368716
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.44797761
9	Proteasome_Homo sapiens_hsa03050	2.24999032
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.22218992
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.20538506
12	Phototransduction_Homo sapiens_hsa04744	1.98831891
13	Parkinsons disease_Homo sapiens_hsa05012	1.98496515
14	Protein export_Homo sapiens_hsa03060	1.95753342
15	Caffeine metabolism_Homo sapiens_hsa00232	1.94703274
16	One carbon pool by folate_Homo sapiens_hsa00670	1.80865196
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.77639394
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.71450855
19	Regulation of autophagy_Homo sapiens_hsa04140	1.71418815
20	Basal transcription factors_Homo sapiens_hsa03022	1.68994616
21	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.56999070
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.52592199
23	RNA degradation_Homo sapiens_hsa03018	1.52141350
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.47297958
25	Antigen processing and presentation_Homo sapiens_hsa04612	1.46869934
26	RNA polymerase_Homo sapiens_hsa03020	1.45938469
27	Nicotine addiction_Homo sapiens_hsa05033	1.44992945
28	Alzheimers disease_Homo sapiens_hsa05010	1.39226152
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.39213560
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.32075782
31	Propanoate metabolism_Homo sapiens_hsa00640	1.31354725
32	Huntingtons disease_Homo sapiens_hsa05016	1.29718602
33	Homologous recombination_Homo sapiens_hsa03440	1.26864233
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.24395069
35	Rheumatoid arthritis_Homo sapiens_hsa05323	1.17069939
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.16782327
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.15591587
38	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.14114912
39	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.12330136
40	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.12119385
41	Retinol metabolism_Homo sapiens_hsa00830	1.09372994
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.07892390
43	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.07460890
44	Tryptophan metabolism_Homo sapiens_hsa00380	1.07386863
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.04559765
46	Butanoate metabolism_Homo sapiens_hsa00650	1.02366744
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01878390
48	Ether lipid metabolism_Homo sapiens_hsa00565	1.00050183
49	Peroxisome_Homo sapiens_hsa04146	0.96818573
50	Olfactory transduction_Homo sapiens_hsa04740	0.95209324
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.94560094
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.86823386
53	Sulfur metabolism_Homo sapiens_hsa00920	0.82595396
54	Fanconi anemia pathway_Homo sapiens_hsa03460	0.82158062
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.80928582
56	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.79487497
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79277673
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77067881
59	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.77049495
60	Morphine addiction_Homo sapiens_hsa05032	0.75967554
61	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.74027917
62	Pyrimidine metabolism_Homo sapiens_hsa00240	0.73236389
63	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.72652918
64	Nucleotide excision repair_Homo sapiens_hsa03420	0.71995672
65	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.70981696
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69223647
67	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66702844
68	Taste transduction_Homo sapiens_hsa04742	0.65502151
69	Purine metabolism_Homo sapiens_hsa00230	0.63597251
70	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.58437463
71	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.54674216
72	Glutamatergic synapse_Homo sapiens_hsa04724	0.52670975
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.51652200
74	Viral myocarditis_Homo sapiens_hsa05416	0.50594608
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50155861
76	Metabolic pathways_Homo sapiens_hsa01100	0.48720972
77	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.47649244
78	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.46688049
79	RNA transport_Homo sapiens_hsa03013	0.44982100
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.44146417
81	Pyruvate metabolism_Homo sapiens_hsa00620	0.43786566
82	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.43142118
83	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.41969235
84	Mismatch repair_Homo sapiens_hsa03430	0.41697673
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41034908
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.40371315
87	Measles_Homo sapiens_hsa05162	0.40316763
88	GABAergic synapse_Homo sapiens_hsa04727	0.35472345
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.35181808
90	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.33493626
91	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.32553276
92	Circadian entrainment_Homo sapiens_hsa04713	0.30949807
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.30770760
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.30677473
95	Serotonergic synapse_Homo sapiens_hsa04726	0.29526331
96	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.28945267
97	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.27297174
98	ABC transporters_Homo sapiens_hsa02010	0.26519751
99	Mineral absorption_Homo sapiens_hsa04978	0.24620346
100	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.23930533

RPL21P116

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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