RPL21P119

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.35590449
2translational termination (GO:0006415)7.15221940
3SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.57363517
4cotranslational protein targeting to membrane (GO:0006613)6.49354721
5ribosomal small subunit assembly (GO:0000028)6.40218983
6protein targeting to ER (GO:0045047)6.39861455
7establishment of protein localization to endoplasmic reticulum (GO:0072599)6.13426253
8protein localization to endoplasmic reticulum (GO:0070972)6.06053275
9translational elongation (GO:0006414)6.04418289
10ribosomal large subunit biogenesis (GO:0042273)5.86483241
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.73888999
12ATP synthesis coupled proton transport (GO:0015986)5.57878399
13energy coupled proton transport, down electrochemical gradient (GO:0015985)5.57878399
14maturation of SSU-rRNA (GO:0030490)5.49600214
15cellular protein complex disassembly (GO:0043624)5.34477327
16transcription elongation from RNA polymerase III promoter (GO:0006385)5.23241001
17termination of RNA polymerase III transcription (GO:0006386)5.23241001
18viral life cycle (GO:0019058)5.19485744
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.13128204
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.10224249
21ribosomal small subunit biogenesis (GO:0042274)5.08971061
22protein complex biogenesis (GO:0070271)4.76967095
23translational initiation (GO:0006413)4.74299811
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.68469764
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.68469764
26NADH dehydrogenase complex assembly (GO:0010257)4.68469764
27respiratory electron transport chain (GO:0022904)4.52833363
28electron transport chain (GO:0022900)4.47417394
29protein complex disassembly (GO:0043241)4.43342760
30protein targeting to membrane (GO:0006612)4.37603024
31establishment of protein localization to mitochondrial membrane (GO:0090151)4.32781323
32macromolecular complex disassembly (GO:0032984)4.19420191
33mitochondrial respiratory chain complex assembly (GO:0033108)4.14848880
34protein neddylation (GO:0045116)4.09686661
35translation (GO:0006412)4.08859393
36behavioral response to nicotine (GO:0035095)3.86450287
37nuclear-transcribed mRNA catabolic process (GO:0000956)3.86370735
38protein localization to cilium (GO:0061512)3.66075763
39mRNA catabolic process (GO:0006402)3.61659554
40platelet dense granule organization (GO:0060155)3.60029109
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.47752517
42nonmotile primary cilium assembly (GO:0035058)3.46123706
43exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.42479665
44hydrogen ion transmembrane transport (GO:1902600)3.39290489
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35150370
46tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35150370
47RNA catabolic process (GO:0006401)3.34423353
48regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.25525877
49chaperone-mediated protein transport (GO:0072321)3.21638044
50ATP biosynthetic process (GO:0006754)3.18180716
51kynurenine metabolic process (GO:0070189)3.18105558
52cellular component biogenesis (GO:0044085)3.16896739
53proton transport (GO:0015992)3.15004901
54negative regulation of mast cell activation (GO:0033004)3.14142465
55hydrogen transport (GO:0006818)3.08175639
56tryptophan catabolic process (GO:0006569)3.03495437
57indole-containing compound catabolic process (GO:0042436)3.03495437
58indolalkylamine catabolic process (GO:0046218)3.03495437
59DNA deamination (GO:0045006)3.00597539
60purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.96186010
61establishment of protein localization to membrane (GO:0090150)2.96017202
62axoneme assembly (GO:0035082)2.94584479
63centriole replication (GO:0007099)2.90324740
64purine nucleoside triphosphate biosynthetic process (GO:0009145)2.90303669
65somite development (GO:0061053)2.86729087
66ribonucleoprotein complex biogenesis (GO:0022613)2.85649294
67positive regulation of gastrulation (GO:2000543)2.83915211
68protein targeting (GO:0006605)2.80819153
69mannosylation (GO:0097502)2.80352242
70regulation of cellular respiration (GO:0043457)2.78034056
71GPI anchor metabolic process (GO:0006505)2.76501519
72aldehyde catabolic process (GO:0046185)2.75873333
73GPI anchor biosynthetic process (GO:0006506)2.70342682
74regulation of cilium movement (GO:0003352)2.69824116
75rRNA catabolic process (GO:0016075)2.68972894
76inner mitochondrial membrane organization (GO:0007007)2.67566862
77negative regulation of response to food (GO:0032096)2.65334255
78negative regulation of appetite (GO:0032099)2.65334255
79pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.61932709
80behavioral response to ethanol (GO:0048149)2.60902718
81epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60621710
82base-excision repair, AP site formation (GO:0006285)2.59737158
83indolalkylamine metabolic process (GO:0006586)2.55136877
84spinal cord association neuron differentiation (GO:0021527)2.55059380
85protein-cofactor linkage (GO:0018065)2.54758702
86endoderm formation (GO:0001706)2.53860850
87cytochrome complex assembly (GO:0017004)2.53536965
88substrate-independent telencephalic tangential migration (GO:0021826)2.53159116
89substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.53159116
90ribonucleoside triphosphate biosynthetic process (GO:0009201)2.51908986
91establishment of protein localization to organelle (GO:0072594)2.51588456
92transcription from RNA polymerase III promoter (GO:0006383)2.49525905
93amine catabolic process (GO:0009310)2.42586812
94cellular biogenic amine catabolic process (GO:0042402)2.42586812
95negative regulation of systemic arterial blood pressure (GO:0003085)2.41284295
96anterograde synaptic vesicle transport (GO:0048490)2.40587245
97detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.37752211
98regulation of mitochondrial translation (GO:0070129)2.37664525
99protein localization to membrane (GO:0072657)2.35603275
100respiratory chain complex IV assembly (GO:0008535)2.35125097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.55409305
2VDR_22108803_ChIP-Seq_LS180_Human3.49625179
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.13048655
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.07541947
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86252282
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75582473
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.70303134
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.64464294
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.51759982
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.46837831
11ZNF274_21170338_ChIP-Seq_K562_Hela2.33290237
12EWS_26573619_Chip-Seq_HEK293_Human2.22930854
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.15968211
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.10402496
15TAF15_26573619_Chip-Seq_HEK293_Human2.06492135
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02607741
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00914371
18GBX2_23144817_ChIP-Seq_PC3_Human1.93796932
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.87954005
20MYC_18940864_ChIP-ChIP_HL60_Human1.83932096
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83682938
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79585386
23VDR_23849224_ChIP-Seq_CD4+_Human1.76420362
24TP53_22573176_ChIP-Seq_HFKS_Human1.74718517
25P300_19829295_ChIP-Seq_ESCs_Human1.72083913
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.67435352
27FUS_26573619_Chip-Seq_HEK293_Human1.64718747
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63268459
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61493837
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60775024
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60337267
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60191947
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59729941
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57024252
35ER_23166858_ChIP-Seq_MCF-7_Human1.52241871
36FOXP3_21729870_ChIP-Seq_TREG_Human1.51598158
37ELK1_19687146_ChIP-ChIP_HELA_Human1.51586560
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47237041
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.45841489
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.45438862
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.45438862
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.45055352
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44157608
44IGF1R_20145208_ChIP-Seq_DFB_Human1.43359190
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42017702
46TTF2_22483619_ChIP-Seq_HELA_Human1.41513269
47AUTS2_25519132_ChIP-Seq_293T-REX_Human1.40381919
48NANOG_19829295_ChIP-Seq_ESCs_Human1.35390305
49SOX2_19829295_ChIP-Seq_ESCs_Human1.35390305
50CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.34386971
51CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32206201
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32086978
53FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.31985681
54JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28869985
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28406743
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.27864214
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27714327
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27380105
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21974752
60IRF1_19129219_ChIP-ChIP_H3396_Human1.20968303
61CBP_20019798_ChIP-Seq_JUKART_Human1.20671901
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20671901
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.19680704
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17933052
65RNF2_27304074_Chip-Seq_NSC_Mouse1.16453142
66NANOG_20526341_ChIP-Seq_ESCs_Human1.15893910
67AR_20517297_ChIP-Seq_VCAP_Human1.15198532
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14035210
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11916104
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10134665
71TCF4_22108803_ChIP-Seq_LS180_Human1.09853663
72NCOR_22424771_ChIP-Seq_293T_Human1.09231767
73EED_16625203_ChIP-ChIP_MESCs_Mouse1.07259591
74PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05801047
75BCAT_22108803_ChIP-Seq_LS180_Human1.05086619
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04975818
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04975818
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.03897468
79REST_21632747_ChIP-Seq_MESCs_Mouse1.02097632
80HTT_18923047_ChIP-ChIP_STHdh_Human1.00269940
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.00183297
82SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99454367
83SMAD3_21741376_ChIP-Seq_EPCs_Human0.99120708
84TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98567167
85EZH2_27294783_Chip-Seq_NPCs_Mouse0.98491724
86EZH2_27294783_Chip-Seq_ESCs_Mouse0.98471527
87GATA3_21878914_ChIP-Seq_MCF-7_Human0.98422349
88RUNX2_22187159_ChIP-Seq_PCA_Human0.97060626
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95698436
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95609040
91TAF2_19829295_ChIP-Seq_ESCs_Human0.95443888
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95430043
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94843608
94SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94158105
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93440682
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.92005282
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91485105
98JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88927861
99SRF_21415370_ChIP-Seq_HL-1_Mouse0.88852948
100MYC_19829295_ChIP-Seq_ESCs_Human0.86674188

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.28156321
2MP0006292_abnormal_olfactory_placode4.06685706
3MP0004142_abnormal_muscle_tone3.31752869
4MP0008789_abnormal_olfactory_epithelium2.32270553
5MP0001835_abnormal_antigen_presentation2.31035563
6MP0002837_dystrophic_cardiac_calcinosis2.27541085
7MP0004145_abnormal_muscle_electrophysio2.23693273
8MP0003122_maternal_imprinting2.23422470
9MP0004147_increased_porphyrin_level2.20725227
10MP0000566_synostosis2.08911292
11MP0003186_abnormal_redox_activity2.06525227
12MP0003567_abnormal_fetal_cardiomyocyte2.03550767
13MP0001529_abnormal_vocalization2.00067939
14MP0005394_taste/olfaction_phenotype1.94535099
15MP0005499_abnormal_olfactory_system1.94535099
16MP0005551_abnormal_eye_electrophysiolog1.91128771
17MP0008877_abnormal_DNA_methylation1.90312109
18MP0008872_abnormal_physiological_respon1.88339458
19MP0005671_abnormal_response_to1.86347275
20MP0001984_abnormal_olfaction1.76202135
21MP0003787_abnormal_imprinting1.74673909
22MP0002938_white_spotting1.73621007
23MP0002234_abnormal_pharynx_morphology1.69974984
24MP0006072_abnormal_retinal_apoptosis1.69158143
25MP0002163_abnormal_gland_morphology1.67694036
26MP0001440_abnormal_grooming_behavior1.67301518
27MP0003011_delayed_dark_adaptation1.66272465
28MP0001485_abnormal_pinna_reflex1.56743291
29MP0000049_abnormal_middle_ear1.55630526
30MP0008875_abnormal_xenobiotic_pharmacok1.54815543
31MP0002102_abnormal_ear_morphology1.54567429
32MP0004885_abnormal_endolymph1.50659527
33MP0005645_abnormal_hypothalamus_physiol1.50048536
34MP0001968_abnormal_touch/_nociception1.49806093
35MP0003121_genomic_imprinting1.47831703
36MP0000372_irregular_coat_pigmentation1.47577121
37MP0001905_abnormal_dopamine_level1.44812346
38MP0001986_abnormal_taste_sensitivity1.41859755
39MP0005389_reproductive_system_phenotype1.38525037
40MP0002160_abnormal_reproductive_system1.36171725
41MP0002653_abnormal_ependyma_morphology1.31765213
42MP0002557_abnormal_social/conspecific_i1.31512097
43MP0000631_abnormal_neuroendocrine_gland1.31499292
44MP0001293_anophthalmia1.30863359
45MP0004742_abnormal_vestibular_system1.27264189
46MP0005377_hearing/vestibular/ear_phenot1.24506631
47MP0003878_abnormal_ear_physiology1.24506631
48MP0002272_abnormal_nervous_system1.23781533
49MP0003890_abnormal_embryonic-extraembry1.23572199
50MP0005253_abnormal_eye_physiology1.22811410
51MP0002277_abnormal_respiratory_mucosa1.20758409
52MP0006276_abnormal_autonomic_nervous1.17493854
53MP0000026_abnormal_inner_ear1.15762833
54MP0001919_abnormal_reproductive_system1.13006101
55MP0003136_yellow_coat_color1.12717645
56MP0002638_abnormal_pupillary_reflex1.12450976
57MP0010030_abnormal_orbit_morphology1.07762850
58MP0003195_calcinosis1.06829861
59MP0003938_abnormal_ear_development1.05670683
60MP0009046_muscle_twitch1.05099313
61MP0004133_heterotaxia1.04750599
62MP0009745_abnormal_behavioral_response1.04272325
63MP0002734_abnormal_mechanical_nocicepti1.04195214
64MP0002067_abnormal_sensory_capabilities1.03147144
65MP0002095_abnormal_skin_pigmentation1.03101328
66MP0001970_abnormal_pain_threshold1.02014121
67MP0005379_endocrine/exocrine_gland_phen1.01876156
68MP0005084_abnormal_gallbladder_morpholo0.99118941
69MP0001486_abnormal_startle_reflex0.98067558
70MP0002736_abnormal_nociception_after0.96832663
71MP0003880_abnormal_central_pattern0.94818668
72MP0001963_abnormal_hearing_physiology0.91296914
73MP0005408_hypopigmentation0.91254221
74MP0005195_abnormal_posterior_eye0.91254111
75MP0002752_abnormal_somatic_nervous0.91055917
76MP0002572_abnormal_emotion/affect_behav0.90331184
77MP0003137_abnormal_impulse_conducting0.89499198
78MP0005636_abnormal_mineral_homeostasis0.88509307
79MP0006036_abnormal_mitochondrial_physio0.88266181
80MP0000639_abnormal_adrenal_gland0.88222611
81MP0003123_paternal_imprinting0.87203406
82MP0005646_abnormal_pituitary_gland0.86195742
83MP0003646_muscle_fatigue0.85132546
84MP0005075_abnormal_melanosome_morpholog0.84919749
85MP0002090_abnormal_vision0.82257938
86MP0000569_abnormal_digit_pigmentation0.81249713
87MP0002233_abnormal_nose_morphology0.81072800
88MP0002733_abnormal_thermal_nociception0.80751290
89MP0002064_seizures0.80140547
90MP0006082_CNS_inflammation0.79738117
91MP0002876_abnormal_thyroid_physiology0.76787806
92MP0002229_neurodegeneration0.75584196
93MP0008995_early_reproductive_senescence0.75308720
94MP0002210_abnormal_sex_determination0.74319666
95MP0000955_abnormal_spinal_cord0.73248640
96MP0001800_abnormal_humoral_immune0.72554701
97MP0003718_maternal_effect0.71330854
98MP0001790_abnormal_immune_system0.71327582
99MP0005387_immune_system_phenotype0.71327582
100MP0002184_abnormal_innervation0.70709071

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.22740595
2Hepatocellular necrosis (HP:0001404)4.64859720
3Abnormal mitochondria in muscle tissue (HP:0008316)4.60777455
4Mitochondrial inheritance (HP:0001427)4.42707321
5Acute encephalopathy (HP:0006846)4.38785080
6Progressive macrocephaly (HP:0004481)4.36625112
7Reticulocytopenia (HP:0001896)4.24277309
8Hepatic necrosis (HP:0002605)4.05346734
9Multiple enchondromatosis (HP:0005701)3.91695443
10Increased CSF lactate (HP:0002490)3.79091717
11Hypomagnesemia (HP:0002917)3.74326363
12Abnormality of midbrain morphology (HP:0002418)3.54303405
13Molar tooth sign on MRI (HP:0002419)3.54303405
14Macrocytic anemia (HP:0001972)3.54300365
15Type II lissencephaly (HP:0007260)3.46081755
16Abnormality of cells of the erythroid lineage (HP:0012130)3.41594189
17Congenital stationary night blindness (HP:0007642)3.34077311
18Stenosis of the external auditory canal (HP:0000402)3.07909016
19Increased hepatocellular lipid droplets (HP:0006565)3.07099193
20Cerebral edema (HP:0002181)3.06943767
21Abnormality of magnesium homeostasis (HP:0004921)3.02750267
22Cerebellar dysplasia (HP:0007033)2.86150837
23Septo-optic dysplasia (HP:0100842)2.84310826
24Abnormal number of erythroid precursors (HP:0012131)2.81002156
25Pallor (HP:0000980)2.75902186
26Lipid accumulation in hepatocytes (HP:0006561)2.73532784
27Median cleft lip (HP:0000161)2.70798979
28Pancreatic cysts (HP:0001737)2.67662042
29Leukodystrophy (HP:0002415)2.66114825
303-Methylglutaconic aciduria (HP:0003535)2.63864153
31Cleft eyelid (HP:0000625)2.63394039
32Abnormal rod and cone electroretinograms (HP:0008323)2.63110385
33Optic disc pallor (HP:0000543)2.61383113
34Respiratory failure (HP:0002878)2.61357664
35Medial flaring of the eyebrow (HP:0010747)2.56743237
36Aplastic anemia (HP:0001915)2.55734974
37Abnormality of the labia minora (HP:0012880)2.51957057
38Nephronophthisis (HP:0000090)2.43512121
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.41860954
40Optic nerve hypoplasia (HP:0000609)2.41562730
41Renal Fanconi syndrome (HP:0001994)2.40723711
42Limb dystonia (HP:0002451)2.35365021
43Type 2 muscle fiber atrophy (HP:0003554)2.33007440
44Methylmalonic acidemia (HP:0002912)2.32639867
45Congenital, generalized hypertrichosis (HP:0004540)2.30841414
46Abolished electroretinogram (ERG) (HP:0000550)2.28956637
47Concave nail (HP:0001598)2.25649340
48Pancreatic fibrosis (HP:0100732)2.22883788
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.22791978
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.22791978
51Increased intramyocellular lipid droplets (HP:0012240)2.20066818
52Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.16043795
53Cerebral palsy (HP:0100021)2.13006910
54Absent septum pellucidum (HP:0001331)2.12643718
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12440600
56Polyuria (HP:0000103)2.10349935
57Hypoplasia of the pons (HP:0012110)2.08346648
58Facial cleft (HP:0002006)2.07698989
59CNS demyelination (HP:0007305)2.07628312
60Pendular nystagmus (HP:0012043)2.07316602
61Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06169674
62Elevated erythrocyte sedimentation rate (HP:0003565)2.04707222
63Abnormal hemoglobin (HP:0011902)2.04441676
64IgG deficiency (HP:0004315)2.04305740
65Decreased central vision (HP:0007663)2.03666072
66Abnormality of the renal medulla (HP:0100957)2.01258562
67Increased serum lactate (HP:0002151)1.98613402
68Exertional dyspnea (HP:0002875)1.97784955
69Aplasia/Hypoplasia of the spleen (HP:0010451)1.96273500
70Lethargy (HP:0001254)1.95728806
71Glossoptosis (HP:0000162)1.95525151
72Split foot (HP:0001839)1.93233157
73Gait imbalance (HP:0002141)1.92049390
74Congenital primary aphakia (HP:0007707)1.90061054
75Symphalangism affecting the phalanges of the hand (HP:0009773)1.88505795
76Asplenia (HP:0001746)1.88135210
77Myokymia (HP:0002411)1.86494793
78Muscle fiber atrophy (HP:0100295)1.85670212
79Lactic acidosis (HP:0003128)1.84939167
80Sclerocornea (HP:0000647)1.84622251
81Synostosis involving the elbow (HP:0003938)1.84398117
82Humeroradial synostosis (HP:0003041)1.84398117
83True hermaphroditism (HP:0010459)1.84177305
84Exercise intolerance (HP:0003546)1.84140901
85Methylmalonic aciduria (HP:0012120)1.84037876
86Abnormality of the pons (HP:0007361)1.83231092
87Tetany (HP:0001281)1.81485809
88Triphalangeal thumb (HP:0001199)1.81246966
89Abnormality of renal resorption (HP:0011038)1.80382084
90X-linked dominant inheritance (HP:0001423)1.80037639
91Stomatitis (HP:0010280)1.75809908
92Colon cancer (HP:0003003)1.75788971
93Blindness (HP:0000618)1.72107722
94Rib fusion (HP:0000902)1.71826111
95Increased muscle lipid content (HP:0009058)1.71283447
96Nephrogenic diabetes insipidus (HP:0009806)1.69833723
97Abnormal urine output (HP:0012590)1.69336982
98Attenuation of retinal blood vessels (HP:0007843)1.67090741
99Porencephaly (HP:0002132)1.66785022
100Choanal stenosis (HP:0000452)1.66483506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.78735514
2MAP3K133.42256042
3ADRBK22.60188629
4TXK2.56123814
5GRK12.53057938
6MUSK2.49016027
7WNK42.21117854
8VRK22.21082147
9WNK32.19700289
10MAP3K42.05888461
11DYRK21.94633565
12MAP4K11.85416140
13BUB11.81491792
14CASK1.81073565
15TLK11.71477603
16PIK3CA1.70211124
17PNCK1.68720022
18STK391.53576133
19MAP3K121.52204166
20PASK1.44497166
21PINK11.43706223
22TAF11.40124416
23CDK191.39965447
24MAP4K21.39839230
25NME21.39318666
26INSRR1.39172211
27NEK11.34149654
28NME11.31929020
29TAOK31.29033188
30FRK1.28361011
31TIE11.28349484
32SCYL21.23041409
33KDR1.20469940
34NUAK11.20296943
35TNIK1.19882088
36IKBKB1.18156353
37CSNK1G21.15892999
38FES1.09711205
39TRIM281.06020003
40FLT31.05890765
41OXSR11.03139367
42ZAK1.00087759
43MAP3K140.98810600
44BCKDK0.98764387
45VRK10.96811462
46CSNK1G30.95487372
47PRKCG0.90855106
48CSNK1G10.89930442
49RPS6KA40.86543241
50PLK10.84806053
51BMPR1B0.82958029
52PRKCQ0.81382347
53DAPK30.80219578
54LRRK20.80105903
55MKNK20.79616799
56ITK0.77595106
57CSNK1A1L0.75645105
58TEC0.74267046
59CSNK2A20.71927103
60CDK30.71518885
61MYLK0.70277979
62STK160.69245916
63RPS6KA50.68343316
64DYRK1B0.68146082
65OBSCN0.67242608
66FGFR10.65774453
67MAPKAPK50.65747349
68FGFR20.63680268
69TYRO30.63271912
70CAMK2A0.62939001
71SYK0.61963994
72WEE10.61792953
73PRKACA0.61252904
74ADRBK10.58262248
75PRKCE0.57710662
76CSNK2A10.57159152
77MAPK130.57145018
78EPHB20.55866940
79PAK30.55311182
80BMPR20.55068878
81MINK10.54094711
82AURKB0.53074750
83CSF1R0.50793049
84DAPK20.50608102
85LYN0.49748946
86KIT0.48718041
87CSNK1E0.46054085
88MAP2K60.45964801
89CHUK0.44323896
90PHKG10.43511288
91PHKG20.43511288
92MAP2K70.43284382
93NTRK20.41797468
94GRK70.41581433
95MKNK10.41422819
96DYRK30.41054473
97PLK30.40274197
98PRKCA0.38148801
99SGK10.37797452
100CAMK10.37531462

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.15291741
2Oxidative phosphorylation_Homo sapiens_hsa001904.23708580
3Parkinsons disease_Homo sapiens_hsa050123.51267722
4Asthma_Homo sapiens_hsa053103.33190495
5Protein export_Homo sapiens_hsa030603.14674378
6RNA polymerase_Homo sapiens_hsa030203.01997465
7Allograft rejection_Homo sapiens_hsa053302.90430978
8Autoimmune thyroid disease_Homo sapiens_hsa053202.76387133
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.56233145
10Graft-versus-host disease_Homo sapiens_hsa053322.47507639
11Alzheimers disease_Homo sapiens_hsa050102.38319250
12Huntingtons disease_Homo sapiens_hsa050162.38066178
13Type I diabetes mellitus_Homo sapiens_hsa049402.32576111
14Proteasome_Homo sapiens_hsa030502.23047444
15Cardiac muscle contraction_Homo sapiens_hsa042602.22550393
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.14702806
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89803383
18Phototransduction_Homo sapiens_hsa047441.61403333
19Homologous recombination_Homo sapiens_hsa034401.54984182
20RNA degradation_Homo sapiens_hsa030181.41320350
21Linoleic acid metabolism_Homo sapiens_hsa005911.35229319
22Rheumatoid arthritis_Homo sapiens_hsa053231.28811146
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27085337
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22899648
25Mismatch repair_Homo sapiens_hsa034301.22833625
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.17187148
27Antigen processing and presentation_Homo sapiens_hsa046121.13038519
28Nicotine addiction_Homo sapiens_hsa050331.12185293
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09274468
30Basal transcription factors_Homo sapiens_hsa030221.00785893
31Viral myocarditis_Homo sapiens_hsa054161.00145528
32Pyrimidine metabolism_Homo sapiens_hsa002400.99560950
33Collecting duct acid secretion_Homo sapiens_hsa049660.98730061
34Primary immunodeficiency_Homo sapiens_hsa053400.98564231
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98129602
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97571488
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94002494
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93706759
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92999766
40Tryptophan metabolism_Homo sapiens_hsa003800.88778263
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87704763
42Caffeine metabolism_Homo sapiens_hsa002320.87698068
43Base excision repair_Homo sapiens_hsa034100.86432007
44Nucleotide excision repair_Homo sapiens_hsa034200.85543488
45Fatty acid elongation_Homo sapiens_hsa000620.84020846
46DNA replication_Homo sapiens_hsa030300.83309224
47Regulation of autophagy_Homo sapiens_hsa041400.78796878
48Systemic lupus erythematosus_Homo sapiens_hsa053220.77233508
49Olfactory transduction_Homo sapiens_hsa047400.75943946
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75297250
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74589157
52Folate biosynthesis_Homo sapiens_hsa007900.73429930
53Purine metabolism_Homo sapiens_hsa002300.73269533
54Chemical carcinogenesis_Homo sapiens_hsa052040.73049719
55Arachidonic acid metabolism_Homo sapiens_hsa005900.70140037
56Staphylococcus aureus infection_Homo sapiens_hsa051500.69741240
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69382649
58RNA transport_Homo sapiens_hsa030130.68236378
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64950995
60Fanconi anemia pathway_Homo sapiens_hsa034600.64521973
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61634912
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59987688
63Retinol metabolism_Homo sapiens_hsa008300.59615879
64Butanoate metabolism_Homo sapiens_hsa006500.58729521
65Taste transduction_Homo sapiens_hsa047420.58251021
66Ether lipid metabolism_Homo sapiens_hsa005650.58120561
67Nitrogen metabolism_Homo sapiens_hsa009100.57830161
68Spliceosome_Homo sapiens_hsa030400.54568339
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.54465753
70Metabolic pathways_Homo sapiens_hsa011000.53151740
71Peroxisome_Homo sapiens_hsa041460.52261977
72Fat digestion and absorption_Homo sapiens_hsa049750.47667382
73Morphine addiction_Homo sapiens_hsa050320.45829617
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.41551793
75Tyrosine metabolism_Homo sapiens_hsa003500.41383731
76Glutathione metabolism_Homo sapiens_hsa004800.41240978
77Propanoate metabolism_Homo sapiens_hsa006400.40614254
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38570214
79Serotonergic synapse_Homo sapiens_hsa047260.36111109
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36007116
81GABAergic synapse_Homo sapiens_hsa047270.35408521
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35277756
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33585063
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30552036
85One carbon pool by folate_Homo sapiens_hsa006700.29663468
86Hematopoietic cell lineage_Homo sapiens_hsa046400.28767638
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28109871
88Circadian entrainment_Homo sapiens_hsa047130.26904239
89Ovarian steroidogenesis_Homo sapiens_hsa049130.26369582
90Glutamatergic synapse_Homo sapiens_hsa047240.25405764
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24800006
92Cocaine addiction_Homo sapiens_hsa050300.24398137
93Epstein-Barr virus infection_Homo sapiens_hsa051690.22870711
94Selenocompound metabolism_Homo sapiens_hsa004500.22690054
95Leishmaniasis_Homo sapiens_hsa051400.22347895
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20270436
97Salivary secretion_Homo sapiens_hsa049700.18564324
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.18563351
99Vitamin digestion and absorption_Homo sapiens_hsa049770.18377791
100Mineral absorption_Homo sapiens_hsa049780.17051003

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