ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.35590449
2	translational termination (GO:0006415)	7.15221940
3	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.57363517
4	cotranslational protein targeting to membrane (GO:0006613)	6.49354721
5	ribosomal small subunit assembly (GO:0000028)	6.40218983
6	protein targeting to ER (GO:0045047)	6.39861455
7	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.13426253
8	protein localization to endoplasmic reticulum (GO:0070972)	6.06053275
9	translational elongation (GO:0006414)	6.04418289
10	ribosomal large subunit biogenesis (GO:0042273)	5.86483241
11	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.73888999
12	ATP synthesis coupled proton transport (GO:0015986)	5.57878399
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.57878399
14	maturation of SSU-rRNA (GO:0030490)	5.49600214
15	cellular protein complex disassembly (GO:0043624)	5.34477327
16	termination of RNA polymerase III transcription (GO:0006386)	5.23241001
17	transcription elongation from RNA polymerase III promoter (GO:0006385)	5.23241001
18	viral life cycle (GO:0019058)	5.19485744
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.13128204
20	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.10224249
21	ribosomal small subunit biogenesis (GO:0042274)	5.08971061
22	protein complex biogenesis (GO:0070271)	4.76967095
23	translational initiation (GO:0006413)	4.74299811
24	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.68469764
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.68469764
26	NADH dehydrogenase complex assembly (GO:0010257)	4.68469764
27	respiratory electron transport chain (GO:0022904)	4.52833363
28	electron transport chain (GO:0022900)	4.47417394
29	protein complex disassembly (GO:0043241)	4.43342760
30	protein targeting to membrane (GO:0006612)	4.37603024
31	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.32781323
32	macromolecular complex disassembly (GO:0032984)	4.19420191
33	mitochondrial respiratory chain complex assembly (GO:0033108)	4.14848880
34	protein neddylation (GO:0045116)	4.09686661
35	translation (GO:0006412)	4.08859393
36	behavioral response to nicotine (GO:0035095)	3.86450287
37	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.86370735
38	protein localization to cilium (GO:0061512)	3.66075763
39	mRNA catabolic process (GO:0006402)	3.61659554
40	platelet dense granule organization (GO:0060155)	3.60029109
41	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.47752517
42	nonmotile primary cilium assembly (GO:0035058)	3.46123706
43	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.42479665
44	hydrogen ion transmembrane transport (GO:1902600)	3.39290489
45	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.35150370
46	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.35150370
47	RNA catabolic process (GO:0006401)	3.34423353
48	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.25525877
49	chaperone-mediated protein transport (GO:0072321)	3.21638044
50	ATP biosynthetic process (GO:0006754)	3.18180716
51	kynurenine metabolic process (GO:0070189)	3.18105558
52	cellular component biogenesis (GO:0044085)	3.16896739
53	proton transport (GO:0015992)	3.15004901
54	negative regulation of mast cell activation (GO:0033004)	3.14142465
55	hydrogen transport (GO:0006818)	3.08175639
56	tryptophan catabolic process (GO:0006569)	3.03495437
57	indole-containing compound catabolic process (GO:0042436)	3.03495437
58	indolalkylamine catabolic process (GO:0046218)	3.03495437
59	DNA deamination (GO:0045006)	3.00597539
60	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.96186010
61	establishment of protein localization to membrane (GO:0090150)	2.96017202
62	axoneme assembly (GO:0035082)	2.94584479
63	centriole replication (GO:0007099)	2.90324740
64	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.90303669
65	somite development (GO:0061053)	2.86729087
66	ribonucleoprotein complex biogenesis (GO:0022613)	2.85649294
67	positive regulation of gastrulation (GO:2000543)	2.83915211
68	protein targeting (GO:0006605)	2.80819153
69	mannosylation (GO:0097502)	2.80352242
70	regulation of cellular respiration (GO:0043457)	2.78034056
71	GPI anchor metabolic process (GO:0006505)	2.76501519
72	aldehyde catabolic process (GO:0046185)	2.75873333
73	GPI anchor biosynthetic process (GO:0006506)	2.70342682
74	regulation of cilium movement (GO:0003352)	2.69824116
75	rRNA catabolic process (GO:0016075)	2.68972894
76	inner mitochondrial membrane organization (GO:0007007)	2.67566862
77	negative regulation of appetite (GO:0032099)	2.65334255
78	negative regulation of response to food (GO:0032096)	2.65334255
79	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.61932709
80	behavioral response to ethanol (GO:0048149)	2.60902718
81	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.60621710
82	base-excision repair, AP site formation (GO:0006285)	2.59737158
83	indolalkylamine metabolic process (GO:0006586)	2.55136877
84	spinal cord association neuron differentiation (GO:0021527)	2.55059380
85	protein-cofactor linkage (GO:0018065)	2.54758702
86	endoderm formation (GO:0001706)	2.53860850
87	cytochrome complex assembly (GO:0017004)	2.53536965
88	substrate-independent telencephalic tangential migration (GO:0021826)	2.53159116
89	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.53159116
90	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.51908986
91	establishment of protein localization to organelle (GO:0072594)	2.51588456
92	transcription from RNA polymerase III promoter (GO:0006383)	2.49525905
93	cellular biogenic amine catabolic process (GO:0042402)	2.42586812
94	amine catabolic process (GO:0009310)	2.42586812
95	negative regulation of systemic arterial blood pressure (GO:0003085)	2.41284295
96	anterograde synaptic vesicle transport (GO:0048490)	2.40587245
97	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.37752211
98	regulation of mitochondrial translation (GO:0070129)	2.37664525
99	protein localization to membrane (GO:0072657)	2.35603275
100	respiratory chain complex IV assembly (GO:0008535)	2.35125097

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.55409305
2	VDR_22108803_ChIP-Seq_LS180_Human	3.49625179
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.13048655
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.07541947
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.86252282
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.75582473
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.70303134
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.64464294
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.51759982
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.46837831
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.33290237
12	EWS_26573619_Chip-Seq_HEK293_Human	2.22930854
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15968211
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.10402496
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.06492135
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.02607741
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.00914371
18	GBX2_23144817_ChIP-Seq_PC3_Human	1.93796932
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.87954005
20	MYC_18940864_ChIP-ChIP_HL60_Human	1.83932096
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.83682938
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.79585386
23	VDR_23849224_ChIP-Seq_CD4+_Human	1.76420362
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.74718517
25	P300_19829295_ChIP-Seq_ESCs_Human	1.72083913
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.67435352
27	FUS_26573619_Chip-Seq_HEK293_Human	1.64718747
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.63268459
29	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.61493837
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60775024
31	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.60337267
32	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.60191947
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.59729941
34	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.57024252
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.52241871
36	FOXP3_21729870_ChIP-Seq_TREG_Human	1.51598158
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.51586560
38	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.47237041
39	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.45841489
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.45438862
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.45438862
42	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.45055352
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44157608
44	IGF1R_20145208_ChIP-Seq_DFB_Human	1.43359190
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42017702
46	TTF2_22483619_ChIP-Seq_HELA_Human	1.41513269
47	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.40381919
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35390305
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35390305
50	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.34386971
51	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.32206201
52	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.32086978
53	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.31985681
54	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.28869985
55	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.28406743
56	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.27864214
57	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.27714327
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27380105
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21974752
60	IRF1_19129219_ChIP-ChIP_H3396_Human	1.20968303
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20671901
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.20671901
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.19680704
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.17933052
65	RNF2_27304074_Chip-Seq_NSC_Mouse	1.16453142
66	NANOG_20526341_ChIP-Seq_ESCs_Human	1.15893910
67	AR_20517297_ChIP-Seq_VCAP_Human	1.15198532
68	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.14035210
69	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11916104
70	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.10134665
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.09853663
72	NCOR_22424771_ChIP-Seq_293T_Human	1.09231767
73	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.07259591
74	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.05801047
75	BCAT_22108803_ChIP-Seq_LS180_Human	1.05086619
76	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04975818
77	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.04975818
78	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.03897468
79	REST_21632747_ChIP-Seq_MESCs_Mouse	1.02097632
80	HTT_18923047_ChIP-ChIP_STHdh_Human	1.00269940
81	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.00183297
82	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.99454367
83	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.99120708
84	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98567167
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.98491724
86	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.98471527
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98422349
88	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97060626
89	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.95698436
90	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.95609040
91	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95443888
92	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.95430043
93	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94843608
94	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.94158105
95	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.93440682
96	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.92005282
97	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.91485105
98	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.88927861
99	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.88852948
100	MYC_19829295_ChIP-Seq_ESCs_Human	0.86674188

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.28156321
2	MP0006292_abnormal_olfactory_placode	4.06685706
3	MP0004142_abnormal_muscle_tone	3.31752869
4	MP0008789_abnormal_olfactory_epithelium	2.32270553
5	MP0001835_abnormal_antigen_presentation	2.31035563
6	MP0002837_dystrophic_cardiac_calcinosis	2.27541085
7	MP0004145_abnormal_muscle_electrophysio	2.23693273
8	MP0003122_maternal_imprinting	2.23422470
9	MP0004147_increased_porphyrin_level	2.20725227
10	MP0000566_synostosis	2.08911292
11	MP0003186_abnormal_redox_activity	2.06525227
12	MP0003567_abnormal_fetal_cardiomyocyte	2.03550767
13	MP0001529_abnormal_vocalization	2.00067939
14	MP0005499_abnormal_olfactory_system	1.94535099
15	MP0005394_taste/olfaction_phenotype	1.94535099
16	MP0005551_abnormal_eye_electrophysiolog	1.91128771
17	MP0008877_abnormal_DNA_methylation	1.90312109
18	MP0008872_abnormal_physiological_respon	1.88339458
19	MP0005671_abnormal_response_to	1.86347275
20	MP0001984_abnormal_olfaction	1.76202135
21	MP0003787_abnormal_imprinting	1.74673909
22	MP0002938_white_spotting	1.73621007
23	MP0002234_abnormal_pharynx_morphology	1.69974984
24	MP0006072_abnormal_retinal_apoptosis	1.69158143
25	MP0002163_abnormal_gland_morphology	1.67694036
26	MP0001440_abnormal_grooming_behavior	1.67301518
27	MP0003011_delayed_dark_adaptation	1.66272465
28	MP0001485_abnormal_pinna_reflex	1.56743291
29	MP0000049_abnormal_middle_ear	1.55630526
30	MP0008875_abnormal_xenobiotic_pharmacok	1.54815543
31	MP0002102_abnormal_ear_morphology	1.54567429
32	MP0004885_abnormal_endolymph	1.50659527
33	MP0005645_abnormal_hypothalamus_physiol	1.50048536
34	MP0001968_abnormal_touch/_nociception	1.49806093
35	MP0003121_genomic_imprinting	1.47831703
36	MP0000372_irregular_coat_pigmentation	1.47577121
37	MP0001905_abnormal_dopamine_level	1.44812346
38	MP0001986_abnormal_taste_sensitivity	1.41859755
39	MP0005389_reproductive_system_phenotype	1.38525037
40	MP0002160_abnormal_reproductive_system	1.36171725
41	MP0002653_abnormal_ependyma_morphology	1.31765213
42	MP0002557_abnormal_social/conspecific_i	1.31512097
43	MP0000631_abnormal_neuroendocrine_gland	1.31499292
44	MP0001293_anophthalmia	1.30863359
45	MP0004742_abnormal_vestibular_system	1.27264189
46	MP0003878_abnormal_ear_physiology	1.24506631
47	MP0005377_hearing/vestibular/ear_phenot	1.24506631
48	MP0002272_abnormal_nervous_system	1.23781533
49	MP0003890_abnormal_embryonic-extraembry	1.23572199
50	MP0005253_abnormal_eye_physiology	1.22811410
51	MP0002277_abnormal_respiratory_mucosa	1.20758409
52	MP0006276_abnormal_autonomic_nervous	1.17493854
53	MP0000026_abnormal_inner_ear	1.15762833
54	MP0001919_abnormal_reproductive_system	1.13006101
55	MP0003136_yellow_coat_color	1.12717645
56	MP0002638_abnormal_pupillary_reflex	1.12450976
57	MP0010030_abnormal_orbit_morphology	1.07762850
58	MP0003195_calcinosis	1.06829861
59	MP0003938_abnormal_ear_development	1.05670683
60	MP0009046_muscle_twitch	1.05099313
61	MP0004133_heterotaxia	1.04750599
62	MP0009745_abnormal_behavioral_response	1.04272325
63	MP0002734_abnormal_mechanical_nocicepti	1.04195214
64	MP0002067_abnormal_sensory_capabilities	1.03147144
65	MP0002095_abnormal_skin_pigmentation	1.03101328
66	MP0001970_abnormal_pain_threshold	1.02014121
67	MP0005379_endocrine/exocrine_gland_phen	1.01876156
68	MP0005084_abnormal_gallbladder_morpholo	0.99118941
69	MP0001486_abnormal_startle_reflex	0.98067558
70	MP0002736_abnormal_nociception_after	0.96832663
71	MP0003880_abnormal_central_pattern	0.94818668
72	MP0001963_abnormal_hearing_physiology	0.91296914
73	MP0005408_hypopigmentation	0.91254221
74	MP0005195_abnormal_posterior_eye	0.91254111
75	MP0002752_abnormal_somatic_nervous	0.91055917
76	MP0002572_abnormal_emotion/affect_behav	0.90331184
77	MP0003137_abnormal_impulse_conducting	0.89499198
78	MP0005636_abnormal_mineral_homeostasis	0.88509307
79	MP0006036_abnormal_mitochondrial_physio	0.88266181
80	MP0000639_abnormal_adrenal_gland	0.88222611
81	MP0003123_paternal_imprinting	0.87203406
82	MP0005646_abnormal_pituitary_gland	0.86195742
83	MP0003646_muscle_fatigue	0.85132546
84	MP0005075_abnormal_melanosome_morpholog	0.84919749
85	MP0002090_abnormal_vision	0.82257938
86	MP0000569_abnormal_digit_pigmentation	0.81249713
87	MP0002233_abnormal_nose_morphology	0.81072800
88	MP0002733_abnormal_thermal_nociception	0.80751290
89	MP0002064_seizures	0.80140547
90	MP0006082_CNS_inflammation	0.79738117
91	MP0002876_abnormal_thyroid_physiology	0.76787806
92	MP0002229_neurodegeneration	0.75584196
93	MP0008995_early_reproductive_senescence	0.75308720
94	MP0002210_abnormal_sex_determination	0.74319666
95	MP0000955_abnormal_spinal_cord	0.73248640
96	MP0001800_abnormal_humoral_immune	0.72554701
97	MP0003718_maternal_effect	0.71330854
98	MP0001790_abnormal_immune_system	0.71327582
99	MP0005387_immune_system_phenotype	0.71327582
100	MP0002184_abnormal_innervation	0.70709071

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.22740595
2	Hepatocellular necrosis (HP:0001404)	4.64859720
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.60777455
4	Mitochondrial inheritance (HP:0001427)	4.42707321
5	Acute encephalopathy (HP:0006846)	4.38785080
6	Progressive macrocephaly (HP:0004481)	4.36625112
7	Reticulocytopenia (HP:0001896)	4.24277309
8	Hepatic necrosis (HP:0002605)	4.05346734
9	Multiple enchondromatosis (HP:0005701)	3.91695443
10	Increased CSF lactate (HP:0002490)	3.79091717
11	Hypomagnesemia (HP:0002917)	3.74326363
12	Abnormality of midbrain morphology (HP:0002418)	3.54303405
13	Molar tooth sign on MRI (HP:0002419)	3.54303405
14	Macrocytic anemia (HP:0001972)	3.54300365
15	Type II lissencephaly (HP:0007260)	3.46081755
16	Abnormality of cells of the erythroid lineage (HP:0012130)	3.41594189
17	Congenital stationary night blindness (HP:0007642)	3.34077311
18	Stenosis of the external auditory canal (HP:0000402)	3.07909016
19	Increased hepatocellular lipid droplets (HP:0006565)	3.07099193
20	Cerebral edema (HP:0002181)	3.06943767
21	Abnormality of magnesium homeostasis (HP:0004921)	3.02750267
22	Cerebellar dysplasia (HP:0007033)	2.86150837
23	Septo-optic dysplasia (HP:0100842)	2.84310826
24	Abnormal number of erythroid precursors (HP:0012131)	2.81002156
25	Pallor (HP:0000980)	2.75902186
26	Lipid accumulation in hepatocytes (HP:0006561)	2.73532784
27	Median cleft lip (HP:0000161)	2.70798979
28	Pancreatic cysts (HP:0001737)	2.67662042
29	Leukodystrophy (HP:0002415)	2.66114825
30	3-Methylglutaconic aciduria (HP:0003535)	2.63864153
31	Cleft eyelid (HP:0000625)	2.63394039
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.63110385
33	Optic disc pallor (HP:0000543)	2.61383113
34	Respiratory failure (HP:0002878)	2.61357664
35	Medial flaring of the eyebrow (HP:0010747)	2.56743237
36	Aplastic anemia (HP:0001915)	2.55734974
37	Abnormality of the labia minora (HP:0012880)	2.51957057
38	Nephronophthisis (HP:0000090)	2.43512121
39	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.41860954
40	Optic nerve hypoplasia (HP:0000609)	2.41562730
41	Renal Fanconi syndrome (HP:0001994)	2.40723711
42	Limb dystonia (HP:0002451)	2.35365021
43	Type 2 muscle fiber atrophy (HP:0003554)	2.33007440
44	Methylmalonic acidemia (HP:0002912)	2.32639867
45	Congenital, generalized hypertrichosis (HP:0004540)	2.30841414
46	Abolished electroretinogram (ERG) (HP:0000550)	2.28956637
47	Concave nail (HP:0001598)	2.25649340
48	Pancreatic fibrosis (HP:0100732)	2.22883788
49	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.22791978
50	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.22791978
51	Increased intramyocellular lipid droplets (HP:0012240)	2.20066818
52	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.16043795
53	Cerebral palsy (HP:0100021)	2.13006910
54	Absent septum pellucidum (HP:0001331)	2.12643718
55	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.12440600
56	Polyuria (HP:0000103)	2.10349935
57	Hypoplasia of the pons (HP:0012110)	2.08346648
58	Facial cleft (HP:0002006)	2.07698989
59	CNS demyelination (HP:0007305)	2.07628312
60	Pendular nystagmus (HP:0012043)	2.07316602
61	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.06169674
62	Elevated erythrocyte sedimentation rate (HP:0003565)	2.04707222
63	Abnormal hemoglobin (HP:0011902)	2.04441676
64	IgG deficiency (HP:0004315)	2.04305740
65	Decreased central vision (HP:0007663)	2.03666072
66	Abnormality of the renal medulla (HP:0100957)	2.01258562
67	Increased serum lactate (HP:0002151)	1.98613402
68	Exertional dyspnea (HP:0002875)	1.97784955
69	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.96273500
70	Lethargy (HP:0001254)	1.95728806
71	Glossoptosis (HP:0000162)	1.95525151
72	Split foot (HP:0001839)	1.93233157
73	Gait imbalance (HP:0002141)	1.92049390
74	Congenital primary aphakia (HP:0007707)	1.90061054
75	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.88505795
76	Asplenia (HP:0001746)	1.88135210
77	Myokymia (HP:0002411)	1.86494793
78	Muscle fiber atrophy (HP:0100295)	1.85670212
79	Lactic acidosis (HP:0003128)	1.84939167
80	Sclerocornea (HP:0000647)	1.84622251
81	Humeroradial synostosis (HP:0003041)	1.84398117
82	Synostosis involving the elbow (HP:0003938)	1.84398117
83	True hermaphroditism (HP:0010459)	1.84177305
84	Exercise intolerance (HP:0003546)	1.84140901
85	Methylmalonic aciduria (HP:0012120)	1.84037876
86	Abnormality of the pons (HP:0007361)	1.83231092
87	Tetany (HP:0001281)	1.81485809
88	Triphalangeal thumb (HP:0001199)	1.81246966
89	Abnormality of renal resorption (HP:0011038)	1.80382084
90	X-linked dominant inheritance (HP:0001423)	1.80037639
91	Stomatitis (HP:0010280)	1.75809908
92	Colon cancer (HP:0003003)	1.75788971
93	Blindness (HP:0000618)	1.72107722
94	Rib fusion (HP:0000902)	1.71826111
95	Increased muscle lipid content (HP:0009058)	1.71283447
96	Nephrogenic diabetes insipidus (HP:0009806)	1.69833723
97	Abnormal urine output (HP:0012590)	1.69336982
98	Attenuation of retinal blood vessels (HP:0007843)	1.67090741
99	Porencephaly (HP:0002132)	1.66785022
100	Choanal stenosis (HP:0000452)	1.66483506

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	3.78735514
2	MAP3K13	3.42256042
3	ADRBK2	2.60188629
4	TXK	2.56123814
5	GRK1	2.53057938
6	MUSK	2.49016027
7	WNK4	2.21117854
8	VRK2	2.21082147
9	WNK3	2.19700289
10	MAP3K4	2.05888461
11	DYRK2	1.94633565
12	MAP4K1	1.85416140
13	BUB1	1.81491792
14	CASK	1.81073565
15	TLK1	1.71477603
16	PIK3CA	1.70211124
17	PNCK	1.68720022
18	STK39	1.53576133
19	MAP3K12	1.52204166
20	PASK	1.44497166
21	PINK1	1.43706223
22	TAF1	1.40124416
23	CDK19	1.39965447
24	MAP4K2	1.39839230
25	NME2	1.39318666
26	INSRR	1.39172211
27	NEK1	1.34149654
28	NME1	1.31929020
29	TAOK3	1.29033188
30	FRK	1.28361011
31	TIE1	1.28349484
32	SCYL2	1.23041409
33	KDR	1.20469940
34	NUAK1	1.20296943
35	TNIK	1.19882088
36	IKBKB	1.18156353
37	CSNK1G2	1.15892999
38	FES	1.09711205
39	TRIM28	1.06020003
40	FLT3	1.05890765
41	OXSR1	1.03139367
42	ZAK	1.00087759
43	MAP3K14	0.98810600
44	BCKDK	0.98764387
45	VRK1	0.96811462
46	CSNK1G3	0.95487372
47	PRKCG	0.90855106
48	CSNK1G1	0.89930442
49	RPS6KA4	0.86543241
50	PLK1	0.84806053
51	BMPR1B	0.82958029
52	PRKCQ	0.81382347
53	DAPK3	0.80219578
54	LRRK2	0.80105903
55	MKNK2	0.79616799
56	ITK	0.77595106
57	CSNK1A1L	0.75645105
58	TEC	0.74267046
59	CSNK2A2	0.71927103
60	CDK3	0.71518885
61	MYLK	0.70277979
62	STK16	0.69245916
63	RPS6KA5	0.68343316
64	DYRK1B	0.68146082
65	OBSCN	0.67242608
66	FGFR1	0.65774453
67	MAPKAPK5	0.65747349
68	FGFR2	0.63680268
69	TYRO3	0.63271912
70	CAMK2A	0.62939001
71	SYK	0.61963994
72	WEE1	0.61792953
73	PRKACA	0.61252904
74	ADRBK1	0.58262248
75	PRKCE	0.57710662
76	CSNK2A1	0.57159152
77	MAPK13	0.57145018
78	EPHB2	0.55866940
79	PAK3	0.55311182
80	BMPR2	0.55068878
81	MINK1	0.54094711
82	AURKB	0.53074750
83	CSF1R	0.50793049
84	DAPK2	0.50608102
85	LYN	0.49748946
86	KIT	0.48718041
87	CSNK1E	0.46054085
88	MAP2K6	0.45964801
89	CHUK	0.44323896
90	PHKG1	0.43511288
91	PHKG2	0.43511288
92	MAP2K7	0.43284382
93	NTRK2	0.41797468
94	GRK7	0.41581433
95	MKNK1	0.41422819
96	DYRK3	0.41054473
97	PLK3	0.40274197
98	PRKCA	0.38148801
99	SGK1	0.37797452
100	CAMK1	0.37531462

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.15291741
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.23708580
3	Parkinsons disease_Homo sapiens_hsa05012	3.51267722
4	Asthma_Homo sapiens_hsa05310	3.33190495
5	Protein export_Homo sapiens_hsa03060	3.14674378
6	RNA polymerase_Homo sapiens_hsa03020	3.01997465
7	Allograft rejection_Homo sapiens_hsa05330	2.90430978
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.76387133
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.56233145
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.47507639
11	Alzheimers disease_Homo sapiens_hsa05010	2.38319250
12	Huntingtons disease_Homo sapiens_hsa05016	2.38066178
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.32576111
14	Proteasome_Homo sapiens_hsa03050	2.23047444
15	Cardiac muscle contraction_Homo sapiens_hsa04260	2.22550393
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.14702806
17	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.89803383
18	Phototransduction_Homo sapiens_hsa04744	1.61403333
19	Homologous recombination_Homo sapiens_hsa03440	1.54984182
20	RNA degradation_Homo sapiens_hsa03018	1.41320350
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.35229319
22	Rheumatoid arthritis_Homo sapiens_hsa05323	1.28811146
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.27085337
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.22899648
25	Mismatch repair_Homo sapiens_hsa03430	1.22833625
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.17187148
27	Antigen processing and presentation_Homo sapiens_hsa04612	1.13038519
28	Nicotine addiction_Homo sapiens_hsa05033	1.12185293
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.09274468
30	Basal transcription factors_Homo sapiens_hsa03022	1.00785893
31	Viral myocarditis_Homo sapiens_hsa05416	1.00145528
32	Pyrimidine metabolism_Homo sapiens_hsa00240	0.99560950
33	Collecting duct acid secretion_Homo sapiens_hsa04966	0.98730061
34	Primary immunodeficiency_Homo sapiens_hsa05340	0.98564231
35	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.98129602
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.97571488
37	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.94002494
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.93706759
39	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.92999766
40	Tryptophan metabolism_Homo sapiens_hsa00380	0.88778263
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.87704763
42	Caffeine metabolism_Homo sapiens_hsa00232	0.87698068
43	Base excision repair_Homo sapiens_hsa03410	0.86432007
44	Nucleotide excision repair_Homo sapiens_hsa03420	0.85543488
45	Fatty acid elongation_Homo sapiens_hsa00062	0.84020846
46	DNA replication_Homo sapiens_hsa03030	0.83309224
47	Regulation of autophagy_Homo sapiens_hsa04140	0.78796878
48	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.77233508
49	Olfactory transduction_Homo sapiens_hsa04740	0.75943946
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75297250
51	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.74589157
52	Folate biosynthesis_Homo sapiens_hsa00790	0.73429930
53	Purine metabolism_Homo sapiens_hsa00230	0.73269533
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73049719
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.70140037
56	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.69741240
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69382649
58	RNA transport_Homo sapiens_hsa03013	0.68236378
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.64950995
60	Fanconi anemia pathway_Homo sapiens_hsa03460	0.64521973
61	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.61634912
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59987688
63	Retinol metabolism_Homo sapiens_hsa00830	0.59615879
64	Butanoate metabolism_Homo sapiens_hsa00650	0.58729521
65	Taste transduction_Homo sapiens_hsa04742	0.58251021
66	Ether lipid metabolism_Homo sapiens_hsa00565	0.58120561
67	Nitrogen metabolism_Homo sapiens_hsa00910	0.57830161
68	Spliceosome_Homo sapiens_hsa03040	0.54568339
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54465753
70	Metabolic pathways_Homo sapiens_hsa01100	0.53151740
71	Peroxisome_Homo sapiens_hsa04146	0.52261977
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.47667382
73	Morphine addiction_Homo sapiens_hsa05032	0.45829617
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41551793
75	Tyrosine metabolism_Homo sapiens_hsa00350	0.41383731
76	Glutathione metabolism_Homo sapiens_hsa00480	0.41240978
77	Propanoate metabolism_Homo sapiens_hsa00640	0.40614254
78	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.38570214
79	Serotonergic synapse_Homo sapiens_hsa04726	0.36111109
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36007116
81	GABAergic synapse_Homo sapiens_hsa04727	0.35408521
82	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.35277756
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.33585063
84	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.30552036
85	One carbon pool by folate_Homo sapiens_hsa00670	0.29663468
86	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.28767638
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.28109871
88	Circadian entrainment_Homo sapiens_hsa04713	0.26904239
89	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.26369582
90	Glutamatergic synapse_Homo sapiens_hsa04724	0.25405764
91	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.24800006
92	Cocaine addiction_Homo sapiens_hsa05030	0.24398137
93	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.22870711
94	Selenocompound metabolism_Homo sapiens_hsa00450	0.22690054
95	Leishmaniasis_Homo sapiens_hsa05140	0.22347895
96	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.20270436
97	Salivary secretion_Homo sapiens_hsa04970	0.18564324
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.18563351
99	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.18377791
100	Mineral absorption_Homo sapiens_hsa04978	0.17051003

RPL21P119

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »