ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.83516624
2	maturation of SSU-rRNA (GO:0030490)	7.20983013
3	viral transcription (GO:0019083)	7.14018452
4	translational termination (GO:0006415)	6.88523574
5	ribosomal small subunit biogenesis (GO:0042274)	6.22879592
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.02760509
7	cotranslational protein targeting to membrane (GO:0006613)	5.96240673
8	protein targeting to ER (GO:0045047)	5.90213059
9	translational elongation (GO:0006414)	5.75180310
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.68320210
11	protein localization to endoplasmic reticulum (GO:0070972)	5.56097062
12	cellular protein complex disassembly (GO:0043624)	5.11793223
13	behavioral response to nicotine (GO:0035095)	5.09139353
14	ATP synthesis coupled proton transport (GO:0015986)	5.08228364
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.08228364
16	viral life cycle (GO:0019058)	5.07568112
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.93537861
18	ribosomal large subunit biogenesis (GO:0042273)	4.89291919
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.53142228
20	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.53142228
21	NADH dehydrogenase complex assembly (GO:0010257)	4.53142228
22	protein complex biogenesis (GO:0070271)	4.52506341
23	translational initiation (GO:0006413)	4.47995805
24	chaperone-mediated protein transport (GO:0072321)	4.34727779
25	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.33191935
26	protein complex disassembly (GO:0043241)	4.26301966
27	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.24113699
28	mitochondrial respiratory chain complex assembly (GO:0033108)	4.12233610
29	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.11143297
30	protein neddylation (GO:0045116)	4.07534745
31	translation (GO:0006412)	4.06634678
32	macromolecular complex disassembly (GO:0032984)	4.03674727
33	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.97878685
34	protein targeting to membrane (GO:0006612)	3.87945166
35	nonmotile primary cilium assembly (GO:0035058)	3.79939268
36	protein polyglutamylation (GO:0018095)	3.79823055
37	GTP biosynthetic process (GO:0006183)	3.79061140
38	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.77823679
39	cellular component biogenesis (GO:0044085)	3.71645754
40	somite development (GO:0061053)	3.69690186
41	ribonucleoprotein complex biogenesis (GO:0022613)	3.68749953
42	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.63536401
43	substrate-independent telencephalic tangential migration (GO:0021826)	3.59516372
44	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.59516372
45	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.51466027
46	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.50306809
47	electron transport chain (GO:0022900)	3.47381374
48	respiratory electron transport chain (GO:0022904)	3.46861065
49	mRNA catabolic process (GO:0006402)	3.44359699
50	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.40899458
51	termination of RNA polymerase III transcription (GO:0006386)	3.40899458
52	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.39980184
53	regulation of immunoglobulin secretion (GO:0051023)	3.29379034
54	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.23406005
55	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.15838888
56	UTP biosynthetic process (GO:0006228)	3.15211257
57	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.13985458
58	regulation of regulatory T cell differentiation (GO:0045589)	3.13003331
59	RNA catabolic process (GO:0006401)	3.11597594
60	regulation of isotype switching to IgG isotypes (GO:0048302)	3.08608516
61	rRNA processing (GO:0006364)	3.05765052
62	rRNA metabolic process (GO:0016072)	3.04129991
63	respiratory chain complex IV assembly (GO:0008535)	3.01764651
64	L-fucose catabolic process (GO:0042355)	3.01228743
65	fucose catabolic process (GO:0019317)	3.01228743
66	L-fucose metabolic process (GO:0042354)	3.01228743
67	tongue development (GO:0043586)	3.00185078
68	UTP metabolic process (GO:0046051)	2.99214517
69	cardiovascular system development (GO:0072358)	2.98347241
70	regulation of cilium movement (GO:0003352)	2.97947825
71	ATP biosynthetic process (GO:0006754)	2.95873966
72	DNA deamination (GO:0045006)	2.94924881
73	water-soluble vitamin biosynthetic process (GO:0042364)	2.92370201
74	epithelial cilium movement (GO:0003351)	2.91196419
75	hydrogen ion transmembrane transport (GO:1902600)	2.90915768
76	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.89581696
77	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.89581696
78	cell proliferation in forebrain (GO:0021846)	2.84807315
79	base-excision repair, AP site formation (GO:0006285)	2.82184051
80	negative regulation of B cell apoptotic process (GO:0002903)	2.80916744
81	auditory receptor cell differentiation (GO:0042491)	2.79572791
82	pyrimidine nucleotide catabolic process (GO:0006244)	2.78952863
83	regulation of mitotic spindle checkpoint (GO:1903504)	2.73463661
84	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.73463661
85	cilium movement (GO:0003341)	2.72432772
86	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.72226487
87	proton transport (GO:0015992)	2.70638322
88	tRNA processing (GO:0008033)	2.69410228
89	cytochrome complex assembly (GO:0017004)	2.68618894
90	pseudouridine synthesis (GO:0001522)	2.68484233
91	establishment of protein localization to membrane (GO:0090150)	2.67854832
92	cellular ketone body metabolic process (GO:0046950)	2.66026450
93	protein targeting (GO:0006605)	2.64807770
94	hydrogen transport (GO:0006818)	2.63154146
95	establishment of protein localization to organelle (GO:0072594)	2.62261455
96	CTP biosynthetic process (GO:0006241)	2.61909405
97	CTP metabolic process (GO:0046036)	2.61909405
98	rRNA catabolic process (GO:0016075)	2.60978572
99	cilium morphogenesis (GO:0060271)	2.60083105
100	hypothalamus development (GO:0021854)	2.58426039

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.06096430
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.02190142
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.85658999
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.46950362
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.39753642
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.79080973
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.70371321
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.59578714
9	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.49424697
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.41258099
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.34720592
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.12037791
13	VDR_22108803_ChIP-Seq_LS180_Human	2.10466521
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.08100500
15	EWS_26573619_Chip-Seq_HEK293_Human	2.02054893
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.96129663
17	VDR_23849224_ChIP-Seq_CD4+_Human	1.94237497
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.90609656
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.85739982
20	TTF2_22483619_ChIP-Seq_HELA_Human	1.85652269
21	TP53_22573176_ChIP-Seq_HFKS_Human	1.79324561
22	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.75764960
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.73012884
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.70675972
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.70045146
26	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.58637816
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.56479845
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.53008132
29	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.50735585
30	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.46216047
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.45853411
32	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.45732566
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45415313
34	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.42866127
35	GBX2_23144817_ChIP-Seq_PC3_Human	1.42299920
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.40774300
37	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.35791082
38	P300_19829295_ChIP-Seq_ESCs_Human	1.35753438
39	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.35526896
40	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.32885742
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.30894924
42	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.25724755
43	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25381971
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25381971
45	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.25354283
46	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23853909
47	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.20515787
48	FUS_26573619_Chip-Seq_HEK293_Human	1.19512384
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18421118
50	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.16845632
51	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.15959769
52	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.15750825
53	MYC_19829295_ChIP-Seq_ESCs_Human	1.15460406
54	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.15174794
55	TAF15_26573619_Chip-Seq_HEK293_Human	1.14663072
56	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.14074438
57	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.12981285
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12832620
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12832620
60	GABP_19822575_ChIP-Seq_HepG2_Human	1.11903200
61	AR_20517297_ChIP-Seq_VCAP_Human	1.11092963
62	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.10596842
63	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.09639508
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.09603850
65	CBP_20019798_ChIP-Seq_JUKART_Human	1.09056815
66	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09056815
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.08318451
68	NANOG_20526341_ChIP-Seq_ESCs_Human	1.07793008
69	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07060581
70	TAF2_19829295_ChIP-Seq_ESCs_Human	1.06847090
71	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.05568439
72	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.02680306
73	BCAT_22108803_ChIP-Seq_LS180_Human	1.02468326
74	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.02291081
75	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.01924224
76	XRN2_22483619_ChIP-Seq_HELA_Human	1.01571657
77	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.00735867
78	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.00622541
79	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.00517855
80	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00492523
81	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.00492523
82	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.99601844
83	ERA_21632823_ChIP-Seq_H3396_Human	0.99087123
84	ER_23166858_ChIP-Seq_MCF-7_Human	0.98936636
85	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.98457614
86	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.97850677
87	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.97718611
88	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.97524522
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97431038
90	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.97346235
91	NCOR_22424771_ChIP-Seq_293T_Human	0.95699933
92	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.95130226
93	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94034192
94	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.93155322
95	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.93077475
96	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.92786023
97	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92617706
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.91848906
99	REST_21632747_ChIP-Seq_MESCs_Mouse	0.89828655
100	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.88169911

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.28831889
2	MP0006292_abnormal_olfactory_placode	4.87149485
3	MP0002163_abnormal_gland_morphology	3.23991147
4	MP0008877_abnormal_DNA_methylation	3.21240899
5	MP0003787_abnormal_imprinting	2.89925997
6	MP0004142_abnormal_muscle_tone	2.51416472
7	MP0003283_abnormal_digestive_organ	2.43096763
8	MP0003122_maternal_imprinting	2.34335388
9	MP0008789_abnormal_olfactory_epithelium	2.26444761
10	MP0001529_abnormal_vocalization	2.25113497
11	MP0002234_abnormal_pharynx_morphology	2.22712348
12	MP0001293_anophthalmia	2.04122256
13	MP0002102_abnormal_ear_morphology	2.02466993
14	MP0005379_endocrine/exocrine_gland_phen	1.90838756
15	MP0005394_taste/olfaction_phenotype	1.87699214
16	MP0005499_abnormal_olfactory_system	1.87699214
17	MP0004147_increased_porphyrin_level	1.84690978
18	MP0002837_dystrophic_cardiac_calcinosis	1.71532670
19	MP0002938_white_spotting	1.69156962
20	MP0005551_abnormal_eye_electrophysiolog	1.63889991
21	MP0005377_hearing/vestibular/ear_phenot	1.58882795
22	MP0003878_abnormal_ear_physiology	1.58882795
23	MP0001968_abnormal_touch/_nociception	1.54672752
24	MP0002653_abnormal_ependyma_morphology	1.53260669
25	MP0003121_genomic_imprinting	1.50734571
26	MP0002736_abnormal_nociception_after	1.49829525
27	MP0001835_abnormal_antigen_presentation	1.49029753
28	MP0003786_premature_aging	1.48301049
29	MP0010030_abnormal_orbit_morphology	1.46239970
30	MP0006072_abnormal_retinal_apoptosis	1.46234704
31	MP0005646_abnormal_pituitary_gland	1.45135898
32	MP0005084_abnormal_gallbladder_morpholo	1.39821885
33	MP0000372_irregular_coat_pigmentation	1.38193853
34	MP0003646_muscle_fatigue	1.38070262
35	MP0000049_abnormal_middle_ear	1.34931111
36	MP0002272_abnormal_nervous_system	1.33723903
37	MP0001984_abnormal_olfaction	1.33634132
38	MP0008872_abnormal_physiological_respon	1.32181378
39	MP0003195_calcinosis	1.26739325
40	MP0001986_abnormal_taste_sensitivity	1.26151814
41	MP0008875_abnormal_xenobiotic_pharmacok	1.25664367
42	MP0001485_abnormal_pinna_reflex	1.25305133
43	MP0002876_abnormal_thyroid_physiology	1.23422468
44	MP0005408_hypopigmentation	1.22389965
45	MP0008058_abnormal_DNA_repair	1.21623073
46	MP0005671_abnormal_response_to	1.21230262
47	MP0005645_abnormal_hypothalamus_physiol	1.20006569
48	MP0009053_abnormal_anal_canal	1.17238102
49	MP0005174_abnormal_tail_pigmentation	1.13502220
50	MP0002095_abnormal_skin_pigmentation	1.13364526
51	MP0009745_abnormal_behavioral_response	1.09832029
52	MP0002638_abnormal_pupillary_reflex	1.07295803
53	MP0002557_abnormal_social/conspecific_i	1.06067780
54	MP0004742_abnormal_vestibular_system	1.06013116
55	MP0006276_abnormal_autonomic_nervous	1.04299082
56	MP0001486_abnormal_startle_reflex	1.03086153
57	MP0001853_heart_inflammation	1.02952668
58	MP0003186_abnormal_redox_activity	1.01956972
59	MP0002735_abnormal_chemical_nociception	1.00705761
60	MP0001970_abnormal_pain_threshold	1.00642840
61	MP0005367_renal/urinary_system_phenotyp	1.00186358
62	MP0000516_abnormal_urinary_system	1.00186358
63	MP0000631_abnormal_neuroendocrine_gland	1.00144838
64	MP0000569_abnormal_digit_pigmentation	0.99807919
65	MP0000604_amyloidosis	0.99498760
66	MP0005195_abnormal_posterior_eye	0.99145860
67	MP0005389_reproductive_system_phenotype	0.98709058
68	MP0003938_abnormal_ear_development	0.96943488
69	MP0001905_abnormal_dopamine_level	0.96374277
70	MP0005253_abnormal_eye_physiology	0.95251028
71	MP0001919_abnormal_reproductive_system	0.94116715
72	MP0001348_abnormal_lacrimal_gland	0.93454018
73	MP0004885_abnormal_endolymph	0.90638929
74	MP0003937_abnormal_limbs/digits/tail_de	0.90180757
75	MP0002233_abnormal_nose_morphology	0.87121367
76	MP0001440_abnormal_grooming_behavior	0.86586416
77	MP0000685_abnormal_immune_system	0.86508708
78	MP0003136_yellow_coat_color	0.85858373
79	MP0004043_abnormal_pH_regulation	0.84620260
80	MP0004133_heterotaxia	0.84298075
81	MP0000427_abnormal_hair_cycle	0.81975763
82	MP0000026_abnormal_inner_ear	0.81674117
83	MP0002572_abnormal_emotion/affect_behav	0.81138165
84	MP0002733_abnormal_thermal_nociception	0.80554640
85	MP0000778_abnormal_nervous_system	0.78384704
86	MP0005083_abnormal_biliary_tract	0.77805944
87	MP0008995_early_reproductive_senescence	0.76754189
88	MP0002138_abnormal_hepatobiliary_system	0.76228258
89	MP0002752_abnormal_somatic_nervous	0.76073922
90	MP0005391_vision/eye_phenotype	0.75580506
91	MP0002160_abnormal_reproductive_system	0.75234952
92	MP0009046_muscle_twitch	0.74835465
93	MP0001502_abnormal_circadian_rhythm	0.74236515
94	MP0005085_abnormal_gallbladder_physiolo	0.74097729
95	MP0003011_delayed_dark_adaptation	0.74053638
96	MP0003693_abnormal_embryo_hatching	0.71724451
97	MP0002734_abnormal_mechanical_nocicepti	0.71192322
98	MP0001790_abnormal_immune_system	0.70284161
99	MP0005387_immune_system_phenotype	0.70284161
100	MP0003880_abnormal_central_pattern	0.69334566

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.73623783
2	Acute necrotizing encephalopathy (HP:0006965)	4.95806516
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.29565847
4	Abnormality of midbrain morphology (HP:0002418)	4.17124218
5	Molar tooth sign on MRI (HP:0002419)	4.17124218
6	Acute encephalopathy (HP:0006846)	4.10540149
7	Progressive macrocephaly (HP:0004481)	4.10538458
8	Mitochondrial inheritance (HP:0001427)	4.07755039
9	Pancreatic fibrosis (HP:0100732)	3.96464329
10	Abnormality of cells of the erythroid lineage (HP:0012130)	3.82527490
11	Pancreatic cysts (HP:0001737)	3.78311858
12	Increased CSF lactate (HP:0002490)	3.47258546
13	Hepatocellular necrosis (HP:0001404)	3.41912757
14	Stomatitis (HP:0010280)	3.35989687
15	3-Methylglutaconic aciduria (HP:0003535)	3.35747582
16	Macrocytic anemia (HP:0001972)	3.12756528
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.12092607
18	Increased hepatocellular lipid droplets (HP:0006565)	3.07020974
19	Septo-optic dysplasia (HP:0100842)	3.01232048
20	Cerebral edema (HP:0002181)	2.99625813
21	Lipid accumulation in hepatocytes (HP:0006561)	2.93076273
22	Medial flaring of the eyebrow (HP:0010747)	2.90163455
23	Abnormal biliary tract physiology (HP:0012439)	2.87264868
24	Bile duct proliferation (HP:0001408)	2.87264868
25	Congenital, generalized hypertrichosis (HP:0004540)	2.85677724
26	Hepatic necrosis (HP:0002605)	2.85676735
27	Abnormal number of erythroid precursors (HP:0012131)	2.82776901
28	Cystic liver disease (HP:0006706)	2.80593984
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.74007951
30	Optic disc pallor (HP:0000543)	2.68241513
31	True hermaphroditism (HP:0010459)	2.66903513
32	Rib fusion (HP:0000902)	2.65270815
33	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.63584525
34	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.62170695
35	Absent thumb (HP:0009777)	2.61736193
36	Tubular atrophy (HP:0000092)	2.59918426
37	Pendular nystagmus (HP:0012043)	2.53341485
38	Nephronophthisis (HP:0000090)	2.51026983
39	Oligodactyly (hands) (HP:0001180)	2.46644035
40	Leukodystrophy (HP:0002415)	2.45449677
41	Abolished electroretinogram (ERG) (HP:0000550)	2.44292566
42	Gait imbalance (HP:0002141)	2.43267670
43	Pallor (HP:0000980)	2.41442319
44	Congenital primary aphakia (HP:0007707)	2.37471582
45	Abnormality of the renal cortex (HP:0011035)	2.29606451
46	Increased serum lactate (HP:0002151)	2.28069777
47	Postaxial foot polydactyly (HP:0001830)	2.26364271
48	Renal Fanconi syndrome (HP:0001994)	2.23772938
49	Abnormality of the renal medulla (HP:0100957)	2.22775306
50	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.22767091
51	Congenital stationary night blindness (HP:0007642)	2.22703377
52	Hypoplasia of the radius (HP:0002984)	2.20728808
53	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.20568431
54	Anophthalmia (HP:0000528)	2.19342020
55	Abnormal ciliary motility (HP:0012262)	2.18145462
56	IgG deficiency (HP:0004315)	2.16720016
57	Maternal diabetes (HP:0009800)	2.14008008
58	Growth hormone deficiency (HP:0000824)	2.13416443
59	Increased IgM level (HP:0003496)	2.12681135
60	Increased intramyocellular lipid droplets (HP:0012240)	2.10941701
61	Polydipsia (HP:0001959)	2.10583132
62	Abnormal drinking behavior (HP:0030082)	2.10583132
63	Nephrogenic diabetes insipidus (HP:0009806)	2.09127558
64	Exercise intolerance (HP:0003546)	2.08740827
65	Supernumerary spleens (HP:0009799)	2.07789414
66	Lactic acidosis (HP:0003128)	2.03999848
67	11 pairs of ribs (HP:0000878)	2.03335082
68	Bilateral microphthalmos (HP:0007633)	2.01772364
69	Sclerocornea (HP:0000647)	2.01235032
70	Type II lissencephaly (HP:0007260)	1.99835494
71	Respiratory failure (HP:0002878)	1.98242538
72	Agitation (HP:0000713)	1.97973861
73	Keratoconus (HP:0000563)	1.96074020
74	Increased corneal curvature (HP:0100692)	1.96074020
75	Oligodactyly (HP:0012165)	1.95409094
76	Anencephaly (HP:0002323)	1.94711787
77	Asplenia (HP:0001746)	1.92469505
78	Ectopic kidney (HP:0000086)	1.92245156
79	Exertional dyspnea (HP:0002875)	1.92172920
80	Abnormal respiratory motile cilium physiology (HP:0012261)	1.90153256
81	Horseshoe kidney (HP:0000085)	1.88871954
82	Duplicated collecting system (HP:0000081)	1.87661483
83	Forearm undergrowth (HP:0009821)	1.85995218
84	Abnormality of the renal collecting system (HP:0004742)	1.85970193
85	Porencephaly (HP:0002132)	1.85968482
86	Optic nerve hypoplasia (HP:0000609)	1.81627139
87	Abnormal respiratory epithelium morphology (HP:0012253)	1.81346288
88	Abnormal respiratory motile cilium morphology (HP:0005938)	1.81346288
89	Postaxial hand polydactyly (HP:0001162)	1.81192877
90	Abnormality of DNA repair (HP:0003254)	1.80504808
91	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.79715137
92	Triphalangeal thumb (HP:0001199)	1.78860192
93	Bifid tongue (HP:0010297)	1.77744924
94	Vaginal atresia (HP:0000148)	1.77681225
95	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.77601549
96	Abnormal number of incisors (HP:0011064)	1.77486357
97	Abnormality of the labia minora (HP:0012880)	1.76813378
98	Narrow forehead (HP:0000341)	1.76685095
99	Hypoplasia of the ulna (HP:0003022)	1.75892780
100	Absent septum pellucidum (HP:0001331)	1.75516797

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.95276273
2	NUAK1	3.36437216
3	FRK	2.92855486
4	ADRBK2	2.92466969
5	WNK4	2.82588165
6	MAP4K2	2.73575000
7	BMPR1B	2.35859207
8	DYRK2	2.28734021
9	GRK1	2.15416432
10	WNK3	1.97016294
11	STK16	1.87064589
12	CDK19	1.77681041
13	MAP4K1	1.72430549
14	EPHB2	1.62007965
15	PASK	1.61908997
16	LRRK2	1.58415445
17	MKNK2	1.58400442
18	ZAK	1.52298968
19	TLK1	1.52279317
20	PINK1	1.50070802
21	NEK1	1.45927199
22	NME1	1.39900890
23	PNCK	1.38999421
24	TEC	1.36655289
25	INSRR	1.32298837
26	STK39	1.31630026
27	BCKDK	1.28090363
28	VRK2	1.26164994
29	OXSR1	1.26056938
30	MAP3K11	1.25970474
31	TIE1	1.22553512
32	MAP3K12	1.22482979
33	EPHA4	1.20299084
34	PLK4	1.18263618
35	PAK3	1.16650151
36	PHKG2	1.10235161
37	PHKG1	1.10235161
38	BCR	1.06552677
39	TGFBR1	1.04124779
40	TAF1	1.03626981
41	PIK3CA	1.02861764
42	CAMKK2	0.98293552
43	ITK	0.97456685
44	NME2	0.95951459
45	DAPK3	0.95861249
46	CAMK1	0.95396876
47	NLK	0.94295130
48	MAP3K4	0.93410080
49	TAOK3	0.85896914
50	MARK3	0.84669325
51	EIF2AK1	0.84376621
52	VRK1	0.83598825
53	CAMK1G	0.77761302
54	CDK8	0.76887569
55	NEK2	0.74020808
56	WNK1	0.73284415
57	STK11	0.73054690
58	TRIM28	0.69818400
59	MKNK1	0.68923932
60	ATR	0.65208881
61	DAPK2	0.64699342
62	PRKACA	0.63007797
63	CAMK1D	0.62734040
64	ADRBK1	0.62184145
65	ILK	0.62002019
66	PRKCG	0.60459294
67	CSNK1G3	0.55326191
68	FES	0.55254615
69	CSNK2A2	0.54911149
70	CSNK1G1	0.54459428
71	CSNK1G2	0.53997256
72	TSSK6	0.53793896
73	MAP2K6	0.53630079
74	PLK3	0.53172181
75	CDC7	0.53070381
76	AURKB	0.52852778
77	MAP2K7	0.52745022
78	ALK	0.51503412
79	PRKCI	0.50971382
80	PRKCQ	0.50092760
81	EPHA3	0.50038741
82	MAPK13	0.49995624
83	DMPK	0.49812485
84	IKBKB	0.49086183
85	RPS6KA6	0.48496072
86	CASK	0.48196448
87	CSNK1E	0.47250164
88	OBSCN	0.46362060
89	CSNK2A1	0.44934897
90	PLK1	0.44059084
91	PRKDC	0.42785238
92	MYLK	0.42231772
93	BTK	0.41119271
94	RPS6KA5	0.40662138
95	IRAK1	0.39675619
96	PRKCE	0.38245064
97	PRKCH	0.37187406
98	PRKCZ	0.36618978
99	TYRO3	0.35432768
100	CSNK1A1	0.34998079

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.79668799
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.87415065
3	Parkinsons disease_Homo sapiens_hsa05012	3.09698920
4	RNA polymerase_Homo sapiens_hsa03020	2.77185154
5	Asthma_Homo sapiens_hsa05310	2.58275895
6	Protein export_Homo sapiens_hsa03060	2.55209996
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.40574158
8	Huntingtons disease_Homo sapiens_hsa05016	2.22822989
9	Proteasome_Homo sapiens_hsa03050	2.10923974
10	Basal transcription factors_Homo sapiens_hsa03022	2.10520050
11	Alzheimers disease_Homo sapiens_hsa05010	2.09247814
12	Allograft rejection_Homo sapiens_hsa05330	2.04275539
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.03715043
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.97100011
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.96100339
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.95835073
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.94695181
18	RNA degradation_Homo sapiens_hsa03018	1.84358512
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.81195193
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.77549901
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.72672999
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.58379006
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.58272235
24	Homologous recombination_Homo sapiens_hsa03440	1.54419503
25	Type I diabetes mellitus_Homo sapiens_hsa04940	1.50583903
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.44822499
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.41351968
28	Mismatch repair_Homo sapiens_hsa03430	1.32917211
29	One carbon pool by folate_Homo sapiens_hsa00670	1.22790541
30	Phototransduction_Homo sapiens_hsa04744	1.20321714
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.15988140
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.15061330
33	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.14710281
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.10356698
35	Caffeine metabolism_Homo sapiens_hsa00232	1.09909627
36	Butanoate metabolism_Homo sapiens_hsa00650	1.05760625
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.04542579
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.02123352
39	Purine metabolism_Homo sapiens_hsa00230	1.00973307
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.95049852
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.94664006
42	Peroxisome_Homo sapiens_hsa04146	0.93552108
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.92294098
44	Primary immunodeficiency_Homo sapiens_hsa05340	0.90255751
45	Nicotine addiction_Homo sapiens_hsa05033	0.88543280
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.86582852
47	Collecting duct acid secretion_Homo sapiens_hsa04966	0.82309281
48	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.82017557
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80454930
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.79424644
51	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.78633004
52	RNA transport_Homo sapiens_hsa03013	0.78508758
53	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.77925532
54	DNA replication_Homo sapiens_hsa03030	0.75652070
55	Fat digestion and absorption_Homo sapiens_hsa04975	0.75369328
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.70511539
57	Olfactory transduction_Homo sapiens_hsa04740	0.70270825
58	Rheumatoid arthritis_Homo sapiens_hsa05323	0.68896039
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.68828859
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.67973804
61	Spliceosome_Homo sapiens_hsa03040	0.67350001
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67312847
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65940288
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64428467
65	Propanoate metabolism_Homo sapiens_hsa00640	0.64138236
66	Metabolic pathways_Homo sapiens_hsa01100	0.60629551
67	Fatty acid degradation_Homo sapiens_hsa00071	0.60446986
68	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.58969028
69	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.58005149
70	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.55749588
71	Base excision repair_Homo sapiens_hsa03410	0.51816871
72	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.51628559
73	Sulfur metabolism_Homo sapiens_hsa00920	0.50940864
74	Folate biosynthesis_Homo sapiens_hsa00790	0.50872905
75	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.50416402
76	Basal cell carcinoma_Homo sapiens_hsa05217	0.50359194
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.49275179
78	Antigen processing and presentation_Homo sapiens_hsa04612	0.48368135
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.48220259
80	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.47924073
81	Morphine addiction_Homo sapiens_hsa05032	0.46905594
82	Glutathione metabolism_Homo sapiens_hsa00480	0.46372234
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.44821297
84	Taste transduction_Homo sapiens_hsa04742	0.44582506
85	Retinol metabolism_Homo sapiens_hsa00830	0.44235762
86	Mineral absorption_Homo sapiens_hsa04978	0.40955937
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40112826
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.34620838
89	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.32667906
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.30487053
91	Steroid biosynthesis_Homo sapiens_hsa00100	0.27216698
92	Fatty acid metabolism_Homo sapiens_hsa01212	0.26984329
93	Insulin secretion_Homo sapiens_hsa04911	0.26476237
94	Regulation of autophagy_Homo sapiens_hsa04140	0.24018773
95	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.23273958
96	GABAergic synapse_Homo sapiens_hsa04727	0.21550194
97	Sulfur relay system_Homo sapiens_hsa04122	0.20994198
98	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.20866306
99	Glutamatergic synapse_Homo sapiens_hsa04724	0.18890093
100	Serotonergic synapse_Homo sapiens_hsa04726	0.18361416

RPL21P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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