ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.55313707
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.23233678
3	ATP synthesis coupled proton transport (GO:0015986)	5.23233678
4	protein neddylation (GO:0045116)	5.10140805
5	viral transcription (GO:0019083)	4.93049964
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.87772539
7	translational termination (GO:0006415)	4.77721274
8	water-soluble vitamin biosynthetic process (GO:0042364)	4.61453318
9	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.54433777
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.46507721
11	cotranslational protein targeting to membrane (GO:0006613)	4.42882933
12	protein targeting to ER (GO:0045047)	4.41508541
13	behavioral response to nicotine (GO:0035095)	4.36866586
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.23234111
15	protein localization to endoplasmic reticulum (GO:0070972)	4.20456763
16	protein complex biogenesis (GO:0070271)	4.19962894
17	ribosomal small subunit biogenesis (GO:0042274)	4.17999404
18	chaperone-mediated protein transport (GO:0072321)	4.15203373
19	translational elongation (GO:0006414)	4.08150559
20	DNA deamination (GO:0045006)	4.05832149
21	maturation of SSU-rRNA (GO:0030490)	4.03468776
22	respiratory electron transport chain (GO:0022904)	3.99377150
23	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.98376087
24	electron transport chain (GO:0022900)	3.97932154
25	response to pheromone (GO:0019236)	3.96030978
26	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.94483128
27	NADH dehydrogenase complex assembly (GO:0010257)	3.94483128
28	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.94483128
29	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.70187213
30	mitochondrial respiratory chain complex assembly (GO:0033108)	3.66431135
31	viral life cycle (GO:0019058)	3.63794917
32	nonmotile primary cilium assembly (GO:0035058)	3.50010039
33	cellular protein complex disassembly (GO:0043624)	3.46599177
34	GTP biosynthetic process (GO:0006183)	3.45156570
35	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.32214985
36	translational initiation (GO:0006413)	3.27817717
37	hydrogen ion transmembrane transport (GO:1902600)	3.25350217
38	translation (GO:0006412)	3.18814757
39	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.18803608
40	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.18803608
41	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.17424440
42	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.16634402
43	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.15212179
44	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.14232644
45	regulation of cilium movement (GO:0003352)	3.09224760
46	platelet dense granule organization (GO:0060155)	3.06641054
47	axoneme assembly (GO:0035082)	3.06303652
48	ATP biosynthetic process (GO:0006754)	3.05756055
49	proton transport (GO:0015992)	3.05629707
50	ribosomal large subunit biogenesis (GO:0042273)	3.03220796
51	hydrogen transport (GO:0006818)	2.99694965
52	protein polyglutamylation (GO:0018095)	2.98029645
53	organelle disassembly (GO:1903008)	2.94267217
54	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.89287661
55	termination of RNA polymerase III transcription (GO:0006386)	2.89287661
56	negative regulation of heart rate (GO:0010459)	2.86689072
57	regulation of action potential (GO:0098900)	2.86327691
58	protein targeting to membrane (GO:0006612)	2.86322697
59	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.86165844
60	positive regulation of respiratory burst (GO:0060267)	2.83535249
61	respiratory chain complex IV assembly (GO:0008535)	2.83407857
62	preassembly of GPI anchor in ER membrane (GO:0016254)	2.78076971
63	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.77630926
64	substrate-independent telencephalic tangential migration (GO:0021826)	2.77630926
65	auditory receptor cell differentiation (GO:0042491)	2.76970577
66	somite development (GO:0061053)	2.76848252
67	protein complex disassembly (GO:0043241)	2.76743123
68	macromolecular complex disassembly (GO:0032984)	2.76453887
69	UTP biosynthetic process (GO:0006228)	2.74315977
70	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.73863966
71	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.73261172
72	cellular component biogenesis (GO:0044085)	2.73211698
73	ribonucleoprotein complex disassembly (GO:0032988)	2.72664892
74	signal peptide processing (GO:0006465)	2.72226864
75	regulation of isotype switching to IgG isotypes (GO:0048302)	2.71074004
76	negative regulation of appetite (GO:0032099)	2.70034253
77	negative regulation of response to food (GO:0032096)	2.70034253
78	epithelial cilium movement (GO:0003351)	2.69829077
79	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.69550521
80	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.67386436
81	cytochrome complex assembly (GO:0017004)	2.66072038
82	intracellular protein transmembrane import (GO:0044743)	2.60216544
83	neuron fate determination (GO:0048664)	2.59594111
84	positive regulation of defense response to virus by host (GO:0002230)	2.58630305
85	interferon-gamma production (GO:0032609)	2.58213451
86	indolalkylamine metabolic process (GO:0006586)	2.57940270
87	dentate gyrus development (GO:0021542)	2.54133056
88	kynurenine metabolic process (GO:0070189)	2.53990210
89	UTP metabolic process (GO:0046051)	2.52976297
90	cell proliferation in forebrain (GO:0021846)	2.52908436
91	rRNA processing (GO:0006364)	2.52503061
92	rRNA metabolic process (GO:0016072)	2.51909704
93	fucose catabolic process (GO:0019317)	2.51229264
94	L-fucose metabolic process (GO:0042354)	2.51229264
95	L-fucose catabolic process (GO:0042355)	2.51229264
96	cytidine deamination (GO:0009972)	2.50419053
97	cytidine metabolic process (GO:0046087)	2.50419053
98	cytidine catabolic process (GO:0006216)	2.50419053
99	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.50354085
100	GPI anchor metabolic process (GO:0006505)	2.50204280

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.64619397
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.63071512
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.49365083
4	VDR_22108803_ChIP-Seq_LS180_Human	3.36522875
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.26217772
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.95798305
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.91306775
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.80595285
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.70478860
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.55275269
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.20472099
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.06323237
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.93063310
14	IGF1R_20145208_ChIP-Seq_DFB_Human	1.90688604
15	VDR_23849224_ChIP-Seq_CD4+_Human	1.85926569
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.82024058
17	EWS_26573619_Chip-Seq_HEK293_Human	1.77838944
18	ELK1_19687146_ChIP-ChIP_HELA_Human	1.76144956
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76085627
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.73828878
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71291380
22	TP53_22573176_ChIP-Seq_HFKS_Human	1.67557928
23	GBX2_23144817_ChIP-Seq_PC3_Human	1.65704942
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.63526896
25	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.63015810
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.62765474
27	P300_19829295_ChIP-Seq_ESCs_Human	1.55473442
28	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.51947685
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.51932202
30	FUS_26573619_Chip-Seq_HEK293_Human	1.48835012
31	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48503699
32	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.47717669
33	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.43940582
34	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.43415295
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42562324
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41108310
37	TAF15_26573619_Chip-Seq_HEK293_Human	1.40493424
38	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40329207
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.37849075
40	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.37836091
41	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.37571827
42	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36862540
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.35540529
44	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.34600894
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30424665
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30424665
47	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.29869520
48	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.29248183
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27579374
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27579374
51	AR_20517297_ChIP-Seq_VCAP_Human	1.24408619
52	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.23963962
53	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.21840818
54	NCOR_22424771_ChIP-Seq_293T_Human	1.20019130
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.17273548
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.17273548
57	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.15716091
58	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.15119596
59	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.13960269
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13310021
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13165595
62	RNF2_27304074_Chip-Seq_NSC_Mouse	1.13033839
63	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11733925
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10890023
65	ERA_21632823_ChIP-Seq_H3396_Human	1.10542839
66	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.09232806
67	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.07204102
68	REST_21632747_ChIP-Seq_MESCs_Mouse	1.07051119
69	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06607358
70	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.06072774
71	BCAT_22108803_ChIP-Seq_LS180_Human	1.05955062
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.04820498
73	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03570237
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03532580
75	MYC_19829295_ChIP-Seq_ESCs_Human	1.03331966
76	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02358859
77	HTT_18923047_ChIP-ChIP_STHdh_Human	1.01441293
78	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00414338
79	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.00265838
80	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.00229932
81	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97719081
82	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96933212
83	ERG_20517297_ChIP-Seq_VCAP_Human	0.96811095
84	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.96634794
85	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96504185
86	TTF2_22483619_ChIP-Seq_HELA_Human	0.96474860
87	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96392484
88	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.96392484
89	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93984867
90	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92770071
91	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.92767848
92	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90484760
93	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.89792242
94	AR_25329375_ChIP-Seq_VCAP_Human	0.88868332
95	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.88700033
96	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88574835
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.88490888
98	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.88090883
99	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.88012636
100	P53_22387025_ChIP-Seq_ESCs_Mouse	0.87306449

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.64079820
2	MP0009379_abnormal_foot_pigmentation	3.53614494
3	MP0003787_abnormal_imprinting	3.33921366
4	MP0008877_abnormal_DNA_methylation	2.95057767
5	MP0008789_abnormal_olfactory_epithelium	2.81414455
6	MP0002638_abnormal_pupillary_reflex	2.59604425
7	MP0006072_abnormal_retinal_apoptosis	2.54413278
8	MP0002102_abnormal_ear_morphology	2.28971069
9	MP0004142_abnormal_muscle_tone	2.22761974
10	MP0002837_dystrophic_cardiac_calcinosis	2.12587973
11	MP0002163_abnormal_gland_morphology	2.12433077
12	MP0005499_abnormal_olfactory_system	2.09644928
13	MP0005394_taste/olfaction_phenotype	2.09644928
14	MP0001968_abnormal_touch/_nociception	2.07173893
15	MP0003646_muscle_fatigue	1.95493927
16	MP0005551_abnormal_eye_electrophysiolog	1.94852282
17	MP0005646_abnormal_pituitary_gland	1.91885414
18	MP0002876_abnormal_thyroid_physiology	1.91245952
19	MP0004885_abnormal_endolymph	1.84324762
20	MP0005671_abnormal_response_to	1.82246820
21	MP0008872_abnormal_physiological_respon	1.80116115
22	MP0000372_irregular_coat_pigmentation	1.66045515
23	MP0002938_white_spotting	1.65701816
24	MP0001485_abnormal_pinna_reflex	1.62420181
25	MP0005379_endocrine/exocrine_gland_phen	1.61768810
26	MP0001986_abnormal_taste_sensitivity	1.61678565
27	MP0002736_abnormal_nociception_after	1.58591846
28	MP0001984_abnormal_olfaction	1.57122636
29	MP0005253_abnormal_eye_physiology	1.56039341
30	MP0003195_calcinosis	1.55704680
31	MP0003880_abnormal_central_pattern	1.55549989
32	MP0005645_abnormal_hypothalamus_physiol	1.45913307
33	MP0001835_abnormal_antigen_presentation	1.44276883
34	MP0003122_maternal_imprinting	1.41086723
35	MP0001873_stomach_inflammation	1.39228209
36	MP0005084_abnormal_gallbladder_morpholo	1.37991025
37	MP0000631_abnormal_neuroendocrine_gland	1.37566812
38	MP0002272_abnormal_nervous_system	1.37346586
39	MP0003121_genomic_imprinting	1.37032730
40	MP0002138_abnormal_hepatobiliary_system	1.35469271
41	MP0002160_abnormal_reproductive_system	1.33322347
42	MP0003011_delayed_dark_adaptation	1.31522841
43	MP0004133_heterotaxia	1.31400089
44	MP0006276_abnormal_autonomic_nervous	1.30363727
45	MP0009046_muscle_twitch	1.29673840
46	MP0009745_abnormal_behavioral_response	1.29571676
47	MP0005389_reproductive_system_phenotype	1.26525282
48	MP0002653_abnormal_ependyma_morphology	1.25288963
49	MP0001905_abnormal_dopamine_level	1.24034066
50	MP0001293_anophthalmia	1.18760316
51	MP0001919_abnormal_reproductive_system	1.17175846
52	MP0004147_increased_porphyrin_level	1.14660216
53	MP0001970_abnormal_pain_threshold	1.14595111
54	MP0001529_abnormal_vocalization	1.13313044
55	MP0002557_abnormal_social/conspecific_i	1.10287453
56	MP0008875_abnormal_xenobiotic_pharmacok	1.09956456
57	MP0002733_abnormal_thermal_nociception	1.09330256
58	MP0004742_abnormal_vestibular_system	1.08671453
59	MP0005195_abnormal_posterior_eye	1.07113276
60	MP0003283_abnormal_digestive_organ	1.05428953
61	MP0002693_abnormal_pancreas_physiology	1.02692955
62	MP0004145_abnormal_muscle_electrophysio	1.01182493
63	MP0002234_abnormal_pharynx_morphology	1.00643430
64	MP0002734_abnormal_mechanical_nocicepti	0.99436497
65	MP0002277_abnormal_respiratory_mucosa	0.98994535
66	MP0005075_abnormal_melanosome_morpholog	0.92627217
67	MP0005636_abnormal_mineral_homeostasis	0.92407262
68	MP0005377_hearing/vestibular/ear_phenot	0.91613855
69	MP0003878_abnormal_ear_physiology	0.91613855
70	MP0002572_abnormal_emotion/affect_behav	0.91423499
71	MP0001440_abnormal_grooming_behavior	0.90790492
72	MP0008995_early_reproductive_senescence	0.90593628
73	MP0002752_abnormal_somatic_nervous	0.87024657
74	MP0004043_abnormal_pH_regulation	0.86729819
75	MP0001486_abnormal_startle_reflex	0.86236777
76	MP0008775_abnormal_heart_ventricle	0.86073476
77	MP0000427_abnormal_hair_cycle	0.85833052
78	MP0002095_abnormal_skin_pigmentation	0.85047585
79	MP0001502_abnormal_circadian_rhythm	0.83966546
80	MP0003866_abnormal_defecation	0.81630549
81	MP0003123_paternal_imprinting	0.80485580
82	MP0000049_abnormal_middle_ear	0.80027162
83	MP0002067_abnormal_sensory_capabilities	0.79431510
84	MP0003786_premature_aging	0.79121083
85	MP0006036_abnormal_mitochondrial_physio	0.78931731
86	MP0000230_abnormal_systemic_arterial	0.78872056
87	MP0002184_abnormal_innervation	0.78572005
88	MP0000026_abnormal_inner_ear	0.78187300
89	MP0000685_abnormal_immune_system	0.78177415
90	MP0002064_seizures	0.77873253
91	MP0010386_abnormal_urinary_bladder	0.77441831
92	MP0001501_abnormal_sleep_pattern	0.76933763
93	MP0001944_abnormal_pancreas_morphology	0.76325629
94	MP0001963_abnormal_hearing_physiology	0.75835629
95	MP0002928_abnormal_bile_duct	0.75006747
96	MP0003186_abnormal_redox_activity	0.74323821
97	MP0002254_reproductive_system_inflammat	0.73651611
98	MP0001765_abnormal_ion_homeostasis	0.72955672
99	MP0005332_abnormal_amino_acid	0.72850335
100	MP0001790_abnormal_immune_system	0.70686452

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.74123694
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.16202684
3	Progressive macrocephaly (HP:0004481)	4.05615884
4	Mitochondrial inheritance (HP:0001427)	4.02168384
5	Acute encephalopathy (HP:0006846)	4.00583618
6	Abnormality of midbrain morphology (HP:0002418)	3.75078887
7	Molar tooth sign on MRI (HP:0002419)	3.75078887
8	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.65414017
9	Increased CSF lactate (HP:0002490)	3.61020106
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.52381936
11	Pancreatic cysts (HP:0001737)	3.51907487
12	Congenital stationary night blindness (HP:0007642)	3.51669881
13	Reticulocytopenia (HP:0001896)	3.44664825
14	Increased hepatocellular lipid droplets (HP:0006565)	3.34561208
15	Pancreatic fibrosis (HP:0100732)	3.28531764
16	Lipid accumulation in hepatocytes (HP:0006561)	3.18148297
17	Hepatocellular necrosis (HP:0001404)	3.08685077
18	Methylmalonic acidemia (HP:0002912)	3.02903502
19	3-Methylglutaconic aciduria (HP:0003535)	2.99667456
20	Medial flaring of the eyebrow (HP:0010747)	2.96906342
21	Abnormality of the renal cortex (HP:0011035)	2.93897734
22	Pendular nystagmus (HP:0012043)	2.93729127
23	Hepatic necrosis (HP:0002605)	2.92426971
24	Nephronophthisis (HP:0000090)	2.86126184
25	Cerebral edema (HP:0002181)	2.82055019
26	Renal Fanconi syndrome (HP:0001994)	2.80532618
27	Abolished electroretinogram (ERG) (HP:0000550)	2.67336217
28	Abnormality of cells of the erythroid lineage (HP:0012130)	2.65972003
29	True hermaphroditism (HP:0010459)	2.65757539
30	Optic disc pallor (HP:0000543)	2.62273113
31	Macrocytic anemia (HP:0001972)	2.62011258
32	Renal cortical cysts (HP:0000803)	2.49746687
33	Abnormality of the renal medulla (HP:0100957)	2.46210264
34	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.45278902
35	Colon cancer (HP:0003003)	2.45113995
36	Increased intramyocellular lipid droplets (HP:0012240)	2.44385673
37	Congenital, generalized hypertrichosis (HP:0004540)	2.42358201
38	Decreased central vision (HP:0007663)	2.40611422
39	Hypoplasia of the fovea (HP:0007750)	2.37737033
40	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.37737033
41	Methylmalonic aciduria (HP:0012120)	2.37365999
42	Gait imbalance (HP:0002141)	2.36304752
43	Stomatitis (HP:0010280)	2.35484686
44	Asplenia (HP:0001746)	2.32483979
45	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.32026516
46	Congenital primary aphakia (HP:0007707)	2.29551291
47	Hyperglycinemia (HP:0002154)	2.28921681
48	Increased serum lactate (HP:0002151)	2.28848203
49	Exertional dyspnea (HP:0002875)	2.28596786
50	Increased corneal curvature (HP:0100692)	2.23130802
51	Keratoconus (HP:0000563)	2.23130802
52	Absent thumb (HP:0009777)	2.22405321
53	Tubular atrophy (HP:0000092)	2.18769116
54	Polydipsia (HP:0001959)	2.16265140
55	Abnormal drinking behavior (HP:0030082)	2.16265140
56	Nephrogenic diabetes insipidus (HP:0009806)	2.15015822
57	Lactic acidosis (HP:0003128)	2.12677688
58	Ketosis (HP:0001946)	2.12376238
59	Glycosuria (HP:0003076)	2.09999018
60	Abnormality of urine glucose concentration (HP:0011016)	2.09999018
61	Type II lissencephaly (HP:0007260)	2.09260552
62	IgG deficiency (HP:0004315)	2.07192171
63	Leukodystrophy (HP:0002415)	2.06981156
64	Rib fusion (HP:0000902)	2.06891259
65	Adrenal hypoplasia (HP:0000835)	2.06690620
66	Cystic liver disease (HP:0006706)	2.04302583
67	Abnormal ciliary motility (HP:0012262)	2.03664630
68	Increased muscle lipid content (HP:0009058)	2.01373148
69	Abnormal number of erythroid precursors (HP:0012131)	2.00127697
70	Abnormal respiratory motile cilium physiology (HP:0012261)	1.99993940
71	Respiratory failure (HP:0002878)	1.98443157
72	Septo-optic dysplasia (HP:0100842)	1.97554972
73	Attenuation of retinal blood vessels (HP:0007843)	1.96736193
74	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.95884796
75	Lethargy (HP:0001254)	1.95083722
76	Ketoacidosis (HP:0001993)	1.91991401
77	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.91061987
78	Sclerocornea (HP:0000647)	1.90612903
79	Pallor (HP:0000980)	1.90305566
80	Optic nerve hypoplasia (HP:0000609)	1.88972838
81	Abnormality of the labia minora (HP:0012880)	1.88146309
82	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.87932929
83	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.87932929
84	Exercise intolerance (HP:0003546)	1.86085261
85	Abnormality of the fovea (HP:0000493)	1.85122300
86	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.83939151
87	Agitation (HP:0000713)	1.80351114
88	Hypomagnesemia (HP:0002917)	1.77936598
89	Abnormality of vitamin B metabolism (HP:0004340)	1.77618517
90	Congenital hepatic fibrosis (HP:0002612)	1.74770280
91	Abnormality of renal resorption (HP:0011038)	1.74287708
92	Intestinal atresia (HP:0011100)	1.74088907
93	Polyuria (HP:0000103)	1.73582526
94	Chronic hepatic failure (HP:0100626)	1.72912671
95	Abnormal biliary tract physiology (HP:0012439)	1.71956593
96	Bile duct proliferation (HP:0001408)	1.71956593
97	Hypoplasia of the ulna (HP:0003022)	1.70925196
98	Absent/shortened dynein arms (HP:0200106)	1.69573308
99	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.69573308
100	Abnormal respiratory epithelium morphology (HP:0012253)	1.69507388

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	GRK1	3.32192424
2	FRK	3.27529704
3	TXK	3.02709202
4	MAP4K2	2.90035376
5	ADRBK2	2.71566851
6	NUAK1	2.59965133
7	WNK4	2.46448756
8	TAOK3	2.30398166
9	ZAK	2.22862888
10	CDK19	1.92515898
11	VRK2	1.89515121
12	TIE1	1.74415789
13	MST4	1.70719779
14	WNK3	1.69429390
15	MAP3K12	1.69240101
16	PINK1	1.68077281
17	DYRK2	1.66871191
18	TLK1	1.62898696
19	STK39	1.57575846
20	OXSR1	1.55165753
21	BCKDK	1.51167231
22	MAPK13	1.42695376
23	PAK3	1.41525266
24	PASK	1.33023099
25	TEC	1.32953555
26	NME1	1.27996590
27	VRK1	1.25801362
28	TRIM28	1.25799500
29	INSRR	1.20762363
30	BMPR1B	1.18880849
31	ITK	1.13153195
32	CASK	1.10157518
33	EIF2AK1	1.03666091
34	PRKCG	1.02475560
35	FES	0.99913867
36	MAP2K6	0.99152450
37	PHKG1	0.98745132
38	PHKG2	0.98745132
39	MYLK	0.98450233
40	STK16	0.97920146
41	MAP4K1	0.95435519
42	CAMKK2	0.94019766
43	PIK3CA	0.93961316
44	TAF1	0.88303830
45	DAPK2	0.88108861
46	PLK3	0.86809600
47	CAMK1	0.80808184
48	PTK2B	0.80422805
49	HIPK2	0.80091228
50	EIF2AK3	0.78278597
51	GRK5	0.77959876
52	PRKCQ	0.74090914
53	MAP3K4	0.73204829
54	CSNK1G1	0.73134386
55	DAPK3	0.71582711
56	IKBKB	0.70841658
57	DAPK1	0.70464459
58	TNIK	0.69571959
59	CSNK1G3	0.69549985
60	CSNK1G2	0.67721745
61	PRKCE	0.67627695
62	TNK2	0.67338085
63	ADRBK1	0.67227856
64	PRKACA	0.64106744
65	PLK2	0.63472204
66	BTK	0.61756862
67	NLK	0.60993835
68	MAPKAPK5	0.59719196
69	STK11	0.59557412
70	WNK1	0.56986371
71	MAP2K7	0.55997248
72	SYK	0.55774134
73	TYRO3	0.55646339
74	STK38L	0.55357933
75	RPS6KA5	0.54963741
76	LRRK2	0.54028022
77	PRKCH	0.51312608
78	CSNK2A2	0.50913422
79	EPHA4	0.49531249
80	OBSCN	0.49105864
81	CSNK1A1	0.48559541
82	CAMK2A	0.48400789
83	PRKCA	0.47938671
84	ERBB3	0.45731321
85	CCNB1	0.45480532
86	CSNK1A1L	0.44823856
87	LYN	0.43060579
88	AKT3	0.42348944
89	NTRK2	0.41284002
90	MUSK	0.41274523
91	CSNK1E	0.40204137
92	CAMK2D	0.40169641
93	CAMKK1	0.39994839
94	GRK6	0.39941181
95	CSNK2A1	0.38913366
96	KDR	0.38689480
97	PLK1	0.36881441
98	SGK223	0.35161031
99	SGK494	0.35161031
100	PDK2	0.34949606

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.48964194
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.33565490
3	Parkinsons disease_Homo sapiens_hsa05012	3.41049393
4	Protein export_Homo sapiens_hsa03060	3.34886794
5	Proteasome_Homo sapiens_hsa03050	2.88637382
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.41125229
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.35619282
8	Alzheimers disease_Homo sapiens_hsa05010	2.31210713
9	RNA polymerase_Homo sapiens_hsa03020	2.29631409
10	Huntingtons disease_Homo sapiens_hsa05016	2.26799956
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.15385264
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.14705705
13	Asthma_Homo sapiens_hsa05310	1.86206986
14	Phototransduction_Homo sapiens_hsa04744	1.64059349
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.63999622
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.59320316
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.58266807
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.55566245
19	One carbon pool by folate_Homo sapiens_hsa00670	1.54578538
20	Type I diabetes mellitus_Homo sapiens_hsa04940	1.54357271
21	Homologous recombination_Homo sapiens_hsa03440	1.54071620
22	RNA degradation_Homo sapiens_hsa03018	1.51591903
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.47354821
24	Allograft rejection_Homo sapiens_hsa05330	1.44184872
25	Basal transcription factors_Homo sapiens_hsa03022	1.39908313
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.33288665
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.32965575
28	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.31916047
29	Caffeine metabolism_Homo sapiens_hsa00232	1.30714630
30	Propanoate metabolism_Homo sapiens_hsa00640	1.27050415
31	Butanoate metabolism_Homo sapiens_hsa00650	1.20424872
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.18906687
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17381204
34	Collecting duct acid secretion_Homo sapiens_hsa04966	1.17357776
35	Peroxisome_Homo sapiens_hsa04146	1.11389500
36	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.08720624
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.06151748
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.02150841
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.01314596
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.01278526
41	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.01188911
42	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.00695917
43	Graft-versus-host disease_Homo sapiens_hsa05332	1.00635953
44	Sulfur relay system_Homo sapiens_hsa04122	0.93918376
45	Nicotine addiction_Homo sapiens_hsa05033	0.92984480
46	Fanconi anemia pathway_Homo sapiens_hsa03460	0.92142429
47	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.91692034
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.88236125
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84481320
50	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.82851182
51	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82753880
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.82194508
53	Mismatch repair_Homo sapiens_hsa03430	0.82110150
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81181706
55	Retinol metabolism_Homo sapiens_hsa00830	0.80907317
56	Insulin secretion_Homo sapiens_hsa04911	0.79184881
57	Regulation of autophagy_Homo sapiens_hsa04140	0.79111416
58	Olfactory transduction_Homo sapiens_hsa04740	0.77852414
59	Purine metabolism_Homo sapiens_hsa00230	0.77356922
60	Selenocompound metabolism_Homo sapiens_hsa00450	0.76148788
61	Sulfur metabolism_Homo sapiens_hsa00920	0.76027584
62	Folate biosynthesis_Homo sapiens_hsa00790	0.73902314
63	Rheumatoid arthritis_Homo sapiens_hsa05323	0.73620916
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71982450
65	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.70935738
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.70295173
67	Steroid biosynthesis_Homo sapiens_hsa00100	0.70217367
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.70058069
69	Metabolic pathways_Homo sapiens_hsa01100	0.69082249
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64284067
71	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.64088200
72	Nucleotide excision repair_Homo sapiens_hsa03420	0.62092061
73	Morphine addiction_Homo sapiens_hsa05032	0.60286496
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.59444594
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57918420
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57675891
77	Fat digestion and absorption_Homo sapiens_hsa04975	0.57328965
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.54185757
79	Taste transduction_Homo sapiens_hsa04742	0.52819087
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.50898621
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.49683526
82	RNA transport_Homo sapiens_hsa03013	0.48717111
83	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.47682480
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.46466567
85	Serotonergic synapse_Homo sapiens_hsa04726	0.45537861
86	GABAergic synapse_Homo sapiens_hsa04727	0.43998047
87	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.40898080
88	Antigen processing and presentation_Homo sapiens_hsa04612	0.38514431
89	Fatty acid degradation_Homo sapiens_hsa00071	0.38017317
90	Spliceosome_Homo sapiens_hsa03040	0.34777633
91	Glutathione metabolism_Homo sapiens_hsa00480	0.34593291
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34228796
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.33169582
94	Fatty acid elongation_Homo sapiens_hsa00062	0.31827500
95	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.30585707
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.30394606
97	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.30381780
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.28395444
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.27283438
100	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.26752515

RPL21P120

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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