ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	5.02830573
2	tongue development (GO:0043586)	4.32158283
3	regulation of mesoderm development (GO:2000380)	4.29254513
4	maturation of SSU-rRNA (GO:0030490)	4.26552137
5	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.17849815
6	replication fork processing (GO:0031297)	4.12653055
7	behavioral response to nicotine (GO:0035095)	3.79047767
8	regulation of chronic inflammatory response (GO:0002676)	3.66963550
9	female gonad development (GO:0008585)	3.62707745
10	neurotransmitter catabolic process (GO:0042135)	3.56640461
11	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.56613457
12	nonmotile primary cilium assembly (GO:0035058)	3.56349721
13	chromatin remodeling at centromere (GO:0031055)	3.55287730
14	response to redox state (GO:0051775)	3.51901035
15	chaperone-mediated protein transport (GO:0072321)	3.51782280
16	protein polyglutamylation (GO:0018095)	3.50112187
17	endoderm formation (GO:0001706)	3.40181484
18	DNA replication-dependent nucleosome assembly (GO:0006335)	3.39656398
19	DNA replication-dependent nucleosome organization (GO:0034723)	3.39656398
20	kidney morphogenesis (GO:0060993)	3.38285454
21	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.37713370
22	CENP-A containing nucleosome assembly (GO:0034080)	3.34880926
23	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.29647853
24	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.29597986
25	preassembly of GPI anchor in ER membrane (GO:0016254)	3.25607307
26	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.24083139
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.24055192
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.24055192
29	NADH dehydrogenase complex assembly (GO:0010257)	3.24055192
30	cartilage morphogenesis (GO:0060536)	3.20209793
31	water-soluble vitamin biosynthetic process (GO:0042364)	3.16032086
32	L-fucose catabolic process (GO:0042355)	3.14499472
33	fucose catabolic process (GO:0019317)	3.14499472
34	L-fucose metabolic process (GO:0042354)	3.14499472
35	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.12794606
36	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.11775827
37	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.11373362
38	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.11373362
39	centriole replication (GO:0007099)	3.08708312
40	kinetochore assembly (GO:0051382)	3.07983297
41	recombinational repair (GO:0000725)	3.04239147
42	intraciliary transport (GO:0042073)	3.00097485
43	double-strand break repair via homologous recombination (GO:0000724)	2.99583644
44	lung epithelium development (GO:0060428)	2.98904154
45	kinetochore organization (GO:0051383)	2.97514679
46	DNA deamination (GO:0045006)	2.91537513
47	protein complex biogenesis (GO:0070271)	2.89423695
48	cilium morphogenesis (GO:0060271)	2.83449768
49	glyoxylate metabolic process (GO:0046487)	2.82891968
50	response to pheromone (GO:0019236)	2.82844567
51	histone exchange (GO:0043486)	2.82360261
52	protein K6-linked ubiquitination (GO:0085020)	2.80925186
53	sulfation (GO:0051923)	2.80712702
54	regulation of centriole replication (GO:0046599)	2.79380240
55	pseudouridine synthesis (GO:0001522)	2.78479607
56	nucleotide transmembrane transport (GO:1901679)	2.76238819
57	kynurenine metabolic process (GO:0070189)	2.75387286
58	replicative senescence (GO:0090399)	2.74125043
59	gamma-aminobutyric acid transport (GO:0015812)	2.73711994
60	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.73546550
61	regulation of mitotic spindle checkpoint (GO:1903504)	2.73546550
62	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.72991288
63	mitotic metaphase plate congression (GO:0007080)	2.70524665
64	respiratory chain complex IV assembly (GO:0008535)	2.67358941
65	lysine metabolic process (GO:0006553)	2.67119026
66	lysine catabolic process (GO:0006554)	2.67119026
67	respiratory tube development (GO:0030323)	2.66124600
68	DNA replication checkpoint (GO:0000076)	2.65790525
69	DNA double-strand break processing (GO:0000729)	2.64168287
70	GPI anchor metabolic process (GO:0006505)	2.63313330
71	mitochondrial respiratory chain complex assembly (GO:0033108)	2.59960806
72	tryptophan catabolic process (GO:0006569)	2.57850089
73	indole-containing compound catabolic process (GO:0042436)	2.57850089
74	indolalkylamine catabolic process (GO:0046218)	2.57850089
75	metaphase plate congression (GO:0051310)	2.55917331
76	GTP biosynthetic process (GO:0006183)	2.55678543
77	maturation of 5.8S rRNA (GO:0000460)	2.52874903
78	collecting duct development (GO:0072044)	2.52281741
79	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.51842853
80	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.51842853
81	positive regulation of vascular permeability (GO:0043117)	2.51434173
82	tRNA processing (GO:0008033)	2.50605897
83	somite rostral/caudal axis specification (GO:0032525)	2.49799664
84	dorsal/ventral axis specification (GO:0009950)	2.49724870
85	C-terminal protein lipidation (GO:0006501)	2.49674875
86	isoprenoid biosynthetic process (GO:0008299)	2.47575688
87	indolalkylamine metabolic process (GO:0006586)	2.47197377
88	reciprocal DNA recombination (GO:0035825)	2.46261671
89	reciprocal meiotic recombination (GO:0007131)	2.46261671
90	axoneme assembly (GO:0035082)	2.45193430
91	epithelial cilium movement (GO:0003351)	2.45186323
92	platelet dense granule organization (GO:0060155)	2.44604569
93	cholesterol biosynthetic process (GO:0006695)	2.44408144
94	metanephric tubule development (GO:0072170)	2.43509711
95	metanephric nephron tubule development (GO:0072234)	2.43509711
96	GPI anchor biosynthetic process (GO:0006506)	2.42357662
97	negative regulation of macrophage differentiation (GO:0045650)	2.42132110
98	meiotic chromosome segregation (GO:0045132)	2.41708067
99	detection of light stimulus involved in sensory perception (GO:0050962)	2.41250159
100	detection of light stimulus involved in visual perception (GO:0050908)	2.41250159

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.76734247
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	4.12062294
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.08414307
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.70915329
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.36800025
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.04405572
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.94835867
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.82859384
9	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.62836845
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.58633983
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.53320993
12	IRF1_19129219_ChIP-ChIP_H3396_Human	2.51448734
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.36486800
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.34047414
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.25632789
16	VDR_22108803_ChIP-Seq_LS180_Human	2.25249145
17	EWS_26573619_Chip-Seq_HEK293_Human	2.22671475
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.18476121
19	FUS_26573619_Chip-Seq_HEK293_Human	2.15946149
20	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.14501498
21	MYC_18940864_ChIP-ChIP_HL60_Human	2.06475200
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.03670052
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.01816138
24	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.98852904
25	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.98449088
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.93007074
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.89656126
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.86426805
29	P300_19829295_ChIP-Seq_ESCs_Human	1.82668989
30	VDR_23849224_ChIP-Seq_CD4+_Human	1.80982352
31	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.79785910
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.79478163
33	GBX2_23144817_ChIP-Seq_PC3_Human	1.70217523
34	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.68607379
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59756588
36	FOXP3_21729870_ChIP-Seq_TREG_Human	1.52662139
37	E2F7_22180533_ChIP-Seq_HELA_Human	1.52207116
38	IGF1R_20145208_ChIP-Seq_DFB_Human	1.50915954
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.48712571
40	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.48263821
41	TAF15_26573619_Chip-Seq_HEK293_Human	1.42182551
42	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.38789508
43	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.35591989
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35449912
45	TTF2_22483619_ChIP-Seq_HELA_Human	1.33637591
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32350679
47	GABP_19822575_ChIP-Seq_HepG2_Human	1.31843139
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.30672693
49	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.28091585
50	BCAT_22108803_ChIP-Seq_LS180_Human	1.27951200
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.27844366
52	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.27707056
53	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.26906739
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.25120466
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23903923
56	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23370299
57	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.14138482
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.13148149
59	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.12251311
60	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.12075084
61	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.11738601
62	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11641009
63	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.11091526
64	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.08963438
65	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.06896429
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.04806270
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.04806270
68	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.03457446
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02935769
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.02169352
71	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.99911186
72	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.99817124
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98705527
74	DCP1A_22483619_ChIP-Seq_HELA_Human	0.97459905
75	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.95902927
76	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95480947
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95480947
78	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.94353409
79	AR_25329375_ChIP-Seq_VCAP_Human	0.93333829
80	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.91679529
81	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.91671311
82	STAT3_23295773_ChIP-Seq_U87_Human	0.91066644
83	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.91032658
84	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.90080634
85	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.89586923
86	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.89532338
87	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.88653748
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.88123097
89	XRN2_22483619_ChIP-Seq_HELA_Human	0.88094326
90	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.87855373
91	AR_20517297_ChIP-Seq_VCAP_Human	0.85590020
92	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.85109501
93	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.84979206
94	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.84773664
95	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.84665093
96	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.83328311
97	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.83131527
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.82632397
99	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.82285558
100	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.82228269

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	6.18243686
2	MP0002653_abnormal_ependyma_morphology	4.16724071
3	MP0003890_abnormal_embryonic-extraembry	3.81451362
4	MP0010030_abnormal_orbit_morphology	3.17316009
5	MP0003878_abnormal_ear_physiology	2.86178972
6	MP0005377_hearing/vestibular/ear_phenot	2.86178972
7	MP0003195_calcinosis	2.65439169
8	MP0003787_abnormal_imprinting	2.60448920
9	MP0008877_abnormal_DNA_methylation	2.43673074
10	MP0010094_abnormal_chromosome_stability	2.39455932
11	MP0001485_abnormal_pinna_reflex	2.28542436
12	MP0001293_anophthalmia	2.20373089
13	MP0004142_abnormal_muscle_tone	2.11161144
14	MP0005499_abnormal_olfactory_system	2.02841915
15	MP0005394_taste/olfaction_phenotype	2.02841915
16	MP0006072_abnormal_retinal_apoptosis	1.96960517
17	MP0006292_abnormal_olfactory_placode	1.95023560
18	MP0003122_maternal_imprinting	1.94228707
19	MP0008789_abnormal_olfactory_epithelium	1.88745843
20	MP0003693_abnormal_embryo_hatching	1.80294556
21	MP0002277_abnormal_respiratory_mucosa	1.77785994
22	MP0005551_abnormal_eye_electrophysiolog	1.76089803
23	MP0008058_abnormal_DNA_repair	1.74372030
24	MP0002102_abnormal_ear_morphology	1.73921222
25	MP0003121_genomic_imprinting	1.65866595
26	MP0000427_abnormal_hair_cycle	1.53832116
27	MP0005248_abnormal_Harderian_gland	1.47634023
28	MP0001529_abnormal_vocalization	1.46650705
29	MP0000049_abnormal_middle_ear	1.41804314
30	MP0001919_abnormal_reproductive_system	1.38023683
31	MP0001501_abnormal_sleep_pattern	1.36550291
32	MP0005174_abnormal_tail_pigmentation	1.31442598
33	MP0004885_abnormal_endolymph	1.26217428
34	MP0002272_abnormal_nervous_system	1.24252078
35	MP0003937_abnormal_limbs/digits/tail_de	1.22842339
36	MP0008872_abnormal_physiological_respon	1.22048275
37	MP0008932_abnormal_embryonic_tissue	1.22012222
38	MP0003111_abnormal_nucleus_morphology	1.21518983
39	MP0008995_early_reproductive_senescence	1.20484600
40	MP0003119_abnormal_digestive_system	1.15732577
41	MP0001727_abnormal_embryo_implantation	1.14236764
42	MP0004133_heterotaxia	1.13951345
43	MP0006054_spinal_hemorrhage	1.13419556
44	MP0003077_abnormal_cell_cycle	1.12955494
45	MP0002233_abnormal_nose_morphology	1.12212816
46	MP0005389_reproductive_system_phenotype	1.12170787
47	MP0008875_abnormal_xenobiotic_pharmacok	1.11888057
48	MP0001346_abnormal_lacrimal_gland	1.11465808
49	MP0001286_abnormal_eye_development	1.11267092
50	MP0000778_abnormal_nervous_system	1.08653446
51	MP0005195_abnormal_posterior_eye	1.08564393
52	MP0002095_abnormal_skin_pigmentation	1.07975992
53	MP0003786_premature_aging	1.07654905
54	MP0005646_abnormal_pituitary_gland	1.06857569
55	MP0003567_abnormal_fetal_cardiomyocyte	1.05613494
56	MP0005253_abnormal_eye_physiology	1.04211794
57	MP0002938_white_spotting	1.04145382
58	MP0000631_abnormal_neuroendocrine_gland	1.02567355
59	MP0002210_abnormal_sex_determination	1.01970712
60	MP0004957_abnormal_blastocyst_morpholog	1.01230853
61	MP0005084_abnormal_gallbladder_morpholo	0.99341729
62	MP0008057_abnormal_DNA_replication	0.97975423
63	MP0000647_abnormal_sebaceous_gland	0.96813291
64	MP0004147_increased_porphyrin_level	0.95834546
65	MP0001486_abnormal_startle_reflex	0.94320816
66	MP0003718_maternal_effect	0.91845598
67	MP0000026_abnormal_inner_ear	0.91321836
68	MP0001929_abnormal_gametogenesis	0.90966503
69	MP0002160_abnormal_reproductive_system	0.90205212
70	MP0002254_reproductive_system_inflammat	0.89114665
71	MP0001119_abnormal_female_reproductive	0.88437904
72	MP0001986_abnormal_taste_sensitivity	0.87747952
73	MP0001984_abnormal_olfaction	0.87060056
74	MP0005391_vision/eye_phenotype	0.86444865
75	MP0003646_muscle_fatigue	0.86427553
76	MP0003755_abnormal_palate_morphology	0.85395179
77	MP0001324_abnormal_eye_pigmentation	0.85318508
78	MP0001963_abnormal_hearing_physiology	0.85165805
79	MP0002557_abnormal_social/conspecific_i	0.84128614
80	MP0002736_abnormal_nociception_after	0.84023950
81	MP0002638_abnormal_pupillary_reflex	0.83969351
82	MP0002282_abnormal_trachea_morphology	0.83462076
83	MP0003880_abnormal_central_pattern	0.82907603
84	MP0002111_abnormal_tail_morphology	0.79830767
85	MP0003186_abnormal_redox_activity	0.78808644
86	MP0009764_decreased_sensitivity_to	0.77817110
87	MP0005410_abnormal_fertilization	0.77799726
88	MP0001968_abnormal_touch/_nociception	0.77206621
89	MP0002752_abnormal_somatic_nervous	0.75224458
90	MP0002751_abnormal_autonomic_nervous	0.74445867
91	MP0002572_abnormal_emotion/affect_behav	0.73311608
92	MP0002234_abnormal_pharynx_morphology	0.72375699
93	MP0006276_abnormal_autonomic_nervous	0.71239376
94	MP0000653_abnormal_sex_gland	0.68561567
95	MP0009745_abnormal_behavioral_response	0.68286317
96	MP0005171_absent_coat_pigmentation	0.67725195
97	MP0001145_abnormal_male_reproductive	0.67096494
98	MP0000613_abnormal_salivary_gland	0.66398391
99	MP0003011_delayed_dark_adaptation	0.64113676
100	MP0002249_abnormal_larynx_morphology	0.64026970

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.02042830
2	Septo-optic dysplasia (HP:0100842)	4.00954514
3	True hermaphroditism (HP:0010459)	3.77477372
4	Pancreatic cysts (HP:0001737)	3.68610685
5	Molar tooth sign on MRI (HP:0002419)	3.60187485
6	Abnormality of midbrain morphology (HP:0002418)	3.60187485
7	Nephronophthisis (HP:0000090)	3.42404597
8	Acute encephalopathy (HP:0006846)	3.39828480
9	Abnormality of the ileum (HP:0001549)	3.27172541
10	Acute necrotizing encephalopathy (HP:0006965)	3.26981118
11	Pancreatic fibrosis (HP:0100732)	3.20403880
12	Meckel diverticulum (HP:0002245)	3.17104974
13	Hyperglycinemia (HP:0002154)	3.13382807
14	Medial flaring of the eyebrow (HP:0010747)	3.02385495
15	Tubular atrophy (HP:0000092)	3.01634676
16	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.95084631
17	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.73126331
18	Abnormal mitochondria in muscle tissue (HP:0008316)	2.73016565
19	Progressive macrocephaly (HP:0004481)	2.68676952
20	Abnormality of the renal medulla (HP:0100957)	2.64676271
21	Increased CSF lactate (HP:0002490)	2.61715241
22	Anophthalmia (HP:0000528)	2.58712065
23	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.45674165
24	Chromsome breakage (HP:0040012)	2.45630502
25	Sclerocornea (HP:0000647)	2.41594982
26	Duplicated collecting system (HP:0000081)	2.40368996
27	Abnormality of the preputium (HP:0100587)	2.40305747
28	Abnormality of chromosome stability (HP:0003220)	2.39088627
29	Progressive inability to walk (HP:0002505)	2.29959351
30	Cystic liver disease (HP:0006706)	2.29154280
31	Mitochondrial inheritance (HP:0001427)	2.27644002
32	Colon cancer (HP:0003003)	2.25703729
33	Congenital primary aphakia (HP:0007707)	2.23274691
34	Abnormality of the renal collecting system (HP:0004742)	2.23184688
35	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.22147416
36	Asplenia (HP:0001746)	2.20554455
37	Optic nerve hypoplasia (HP:0000609)	2.18456893
38	Intestinal atresia (HP:0011100)	2.17715389
39	Gait imbalance (HP:0002141)	2.17079681
40	Absent thumb (HP:0009777)	2.15085718
41	Maternal diabetes (HP:0009800)	2.14909330
42	Methylmalonic acidemia (HP:0002912)	2.14698301
43	Polydipsia (HP:0001959)	2.13545380
44	Abnormal drinking behavior (HP:0030082)	2.13545380
45	Congenital stationary night blindness (HP:0007642)	2.12984885
46	Nephrogenic diabetes insipidus (HP:0009806)	2.12589426
47	Duodenal stenosis (HP:0100867)	2.10985832
48	Small intestinal stenosis (HP:0012848)	2.10985832
49	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.09367691
50	Clubbing of toes (HP:0100760)	2.07544968
51	Cerebral edema (HP:0002181)	2.06830863
52	Progressive cerebellar ataxia (HP:0002073)	2.04199338
53	Abnormality of the renal cortex (HP:0011035)	2.02872970
54	Anencephaly (HP:0002323)	2.00910162
55	Dyschromatopsia (HP:0007641)	1.99699967
56	Abolished electroretinogram (ERG) (HP:0000550)	1.99414506
57	Abnormal biliary tract physiology (HP:0012439)	1.97956061
58	Bile duct proliferation (HP:0001408)	1.97956061
59	Triphalangeal thumb (HP:0001199)	1.97348456
60	Absent radius (HP:0003974)	1.97124056
61	Absent septum pellucidum (HP:0001331)	1.97053991
62	Ectopic kidney (HP:0000086)	1.96815824
63	Hepatocellular necrosis (HP:0001404)	1.96612549
64	Horseshoe kidney (HP:0000085)	1.96317848
65	Sloping forehead (HP:0000340)	1.96277093
66	Leukodystrophy (HP:0002415)	1.95507476
67	Vaginal atresia (HP:0000148)	1.94840334
68	Aplasia involving forearm bones (HP:0009822)	1.94101254
69	Absent forearm bone (HP:0003953)	1.94101254
70	Abnormality of the duodenum (HP:0002246)	1.93572545
71	Chronic hepatic failure (HP:0100626)	1.93129055
72	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.92468070
73	Absent/shortened dynein arms (HP:0200106)	1.92468070
74	Optic disc pallor (HP:0000543)	1.91654608
75	Congenital hepatic fibrosis (HP:0002612)	1.91549989
76	Rib fusion (HP:0000902)	1.91102357
77	Abnormality of the septum pellucidum (HP:0007375)	1.89519969
78	Genital tract atresia (HP:0001827)	1.89033853
79	Abnormal lung lobation (HP:0002101)	1.88624663
80	Multiple enchondromatosis (HP:0005701)	1.87837014
81	Abnormality of DNA repair (HP:0003254)	1.87154131
82	Increased serum lactate (HP:0002151)	1.86068734
83	Abnormality of serine family amino acid metabolism (HP:0010894)	1.85470131
84	Abnormality of glycine metabolism (HP:0010895)	1.85470131
85	Large for gestational age (HP:0001520)	1.84578141
86	Delayed CNS myelination (HP:0002188)	1.83855343
87	Abnormality of the labia minora (HP:0012880)	1.82003027
88	Decreased central vision (HP:0007663)	1.81274444
89	Postaxial foot polydactyly (HP:0001830)	1.80499796
90	Aganglionic megacolon (HP:0002251)	1.79780296
91	Abnormality of the carotid arteries (HP:0005344)	1.79384498
92	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.78605528
93	Type II lissencephaly (HP:0007260)	1.77996742
94	Inability to walk (HP:0002540)	1.77761667
95	Abnormal pancreas size (HP:0012094)	1.77647899
96	Esophageal atresia (HP:0002032)	1.75769469
97	Adactyly (HP:0009776)	1.75336608
98	Hyperglycinuria (HP:0003108)	1.75268558
99	Oligohydramnios (HP:0001562)	1.75231797
100	Gastrointestinal atresia (HP:0002589)	1.75146163

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	4.56731659
2	BMPR1B	3.68323412
3	ACVR1B	3.60608274
4	TSSK6	2.93708187
5	TRIM28	2.76256943
6	WNK4	2.76143188
7	CASK	2.47016442
8	STK16	2.46691484
9	TLK1	2.43104835
10	WNK3	2.42820474
11	NUAK1	2.35838234
12	CDC7	2.18191759
13	STK39	2.01724542
14	PLK4	1.92294247
15	WEE1	1.83461476
16	PINK1	1.83293025
17	TGFBR1	1.80560497
18	NME1	1.79446643
19	MKNK2	1.75818678
20	TNIK	1.75355713
21	SRPK1	1.73383152
22	BUB1	1.66404711
23	PDK2	1.53233356
24	MAPK15	1.45358465
25	BCR	1.43833827
26	PLK3	1.42830136
27	FRK	1.42229102
28	MAPKAPK3	1.40194073
29	PBK	1.40026391
30	PNCK	1.38011937
31	VRK1	1.33209829
32	GRK1	1.26422923
33	TXK	1.22208415
34	ERBB4	1.06573487
35	MAP3K9	1.06182160
36	TTK	1.02699463
37	BRSK2	0.99983093
38	BRD4	0.96054740
39	OXSR1	0.95257603
40	PLK1	0.95044878
41	MKNK1	0.92124231
42	MAP4K2	0.90493859
43	ADRBK1	0.87667742
44	CSNK1G1	0.85633679
45	TIE1	0.83463571
46	INSRR	0.82156122
47	MAPK13	0.80191889
48	CAMKK2	0.76433682
49	ADRBK2	0.71618983
50	MST4	0.71051623
51	RPS6KA4	0.70993313
52	AURKB	0.69631307
53	ATR	0.69549477
54	PLK2	0.66777108
55	NEK1	0.62586789
56	PAK3	0.61757463
57	DMPK	0.61730245
58	PKN2	0.57870008
59	CSNK1G2	0.56994289
60	PIK3CA	0.56408919
61	PRKCE	0.55899439
62	AKT3	0.55271130
63	PRKCG	0.54964389
64	FLT3	0.51114014
65	AURKA	0.50747569
66	EPHB2	0.50697942
67	CSNK1G3	0.48172031
68	CDK19	0.47794596
69	EIF2AK3	0.47769049
70	PASK	0.47498253
71	MAP2K6	0.47449593
72	CHEK2	0.46274773
73	NLK	0.46185256
74	NTRK2	0.46151511
75	CDK3	0.44577191
76	MINK1	0.43619522
77	MARK3	0.41219581
78	BRSK1	0.39388004
79	VRK2	0.38913260
80	MAP3K11	0.38873769
81	RPS6KA5	0.38663614
82	STK3	0.36070267
83	CSNK1A1	0.36069434
84	LRRK2	0.35014527
85	ERBB3	0.34630082
86	MAP3K4	0.33003695
87	PRKCQ	0.32746970
88	PTK2B	0.32073039
89	ATM	0.32051948
90	STK10	0.32006430
91	CSNK2A1	0.30908550
92	EIF2AK2	0.30461689
93	CDK8	0.30431528
94	MELK	0.30229569
95	CAMK2A	0.29165427
96	CSNK1A1L	0.26696450
97	PIM2	0.25735161
98	CHEK1	0.25515014
99	WNK1	0.23830233
100	DYRK3	0.22954399

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.81159449
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.73078039
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.71978545
4	Homologous recombination_Homo sapiens_hsa03440	2.54154465
5	Mismatch repair_Homo sapiens_hsa03430	2.52985650
6	Protein export_Homo sapiens_hsa03060	2.46533643
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.43898294
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.35173273
9	Ribosome_Homo sapiens_hsa03010	2.32984367
10	Proteasome_Homo sapiens_hsa03050	2.30208521
11	Propanoate metabolism_Homo sapiens_hsa00640	2.27262998
12	RNA polymerase_Homo sapiens_hsa03020	2.20215946
13	Steroid biosynthesis_Homo sapiens_hsa00100	2.14315118
14	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.12258662
15	RNA degradation_Homo sapiens_hsa03018	2.03784467
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.93634104
17	Butanoate metabolism_Homo sapiens_hsa00650	1.91719835
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.82777553
19	Oxidative phosphorylation_Homo sapiens_hsa00190	1.78083234
20	Caffeine metabolism_Homo sapiens_hsa00232	1.72852874
21	DNA replication_Homo sapiens_hsa03030	1.70896340
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.60099402
23	Parkinsons disease_Homo sapiens_hsa05012	1.55853083
24	Basal transcription factors_Homo sapiens_hsa03022	1.54633059
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.51194699
26	One carbon pool by folate_Homo sapiens_hsa00670	1.48669598
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.47917525
28	Non-homologous end-joining_Homo sapiens_hsa03450	1.40463074
29	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.40352947
30	Phototransduction_Homo sapiens_hsa04744	1.39851283
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.37524589
32	RNA transport_Homo sapiens_hsa03013	1.36981218
33	Basal cell carcinoma_Homo sapiens_hsa05217	1.35176956
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.33055738
35	Peroxisome_Homo sapiens_hsa04146	1.31007014
36	Fatty acid degradation_Homo sapiens_hsa00071	1.26679723
37	Pyruvate metabolism_Homo sapiens_hsa00620	1.24097858
38	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.21317813
39	Linoleic acid metabolism_Homo sapiens_hsa00591	1.21214998
40	Base excision repair_Homo sapiens_hsa03410	1.20623392
41	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.17596227
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.12541477
43	Sulfur metabolism_Homo sapiens_hsa00920	1.09539033
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.09084456
45	Nitrogen metabolism_Homo sapiens_hsa00910	1.08265618
46	Huntingtons disease_Homo sapiens_hsa05016	1.04980360
47	Fatty acid metabolism_Homo sapiens_hsa01212	1.03051645
48	Purine metabolism_Homo sapiens_hsa00230	1.00236795
49	Folate biosynthesis_Homo sapiens_hsa00790	0.98285320
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96038288
51	Nicotine addiction_Homo sapiens_hsa05033	0.94174239
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.93054718
53	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.92311698
54	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.92218094
55	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.89240930
56	Fatty acid elongation_Homo sapiens_hsa00062	0.88409991
57	Lysine degradation_Homo sapiens_hsa00310	0.84016057
58	Hippo signaling pathway_Homo sapiens_hsa04390	0.81352450
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.78142114
60	Selenocompound metabolism_Homo sapiens_hsa00450	0.74314858
61	Sulfur relay system_Homo sapiens_hsa04122	0.74048359
62	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.72941175
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.70923129
64	Regulation of autophagy_Homo sapiens_hsa04140	0.70280348
65	Cell cycle_Homo sapiens_hsa04110	0.67826588
66	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.65987269
67	Spliceosome_Homo sapiens_hsa03040	0.65546857
68	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.65438010
69	Alzheimers disease_Homo sapiens_hsa05010	0.64622837
70	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.64542338
71	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.64383952
72	Metabolic pathways_Homo sapiens_hsa01100	0.64176625
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61872968
74	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.57029109
75	Wnt signaling pathway_Homo sapiens_hsa04310	0.55370660
76	Cardiac muscle contraction_Homo sapiens_hsa04260	0.54708874
77	p53 signaling pathway_Homo sapiens_hsa04115	0.54682606
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52614159
79	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.51429114
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.49687628
81	Taste transduction_Homo sapiens_hsa04742	0.47099994
82	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.46060365
83	Retinol metabolism_Homo sapiens_hsa00830	0.44850504
84	Primary immunodeficiency_Homo sapiens_hsa05340	0.44306371
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.42191250
86	Glutathione metabolism_Homo sapiens_hsa00480	0.42019475
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.42000530
88	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.41941987
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41326170
90	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.38875164
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38095540
92	Morphine addiction_Homo sapiens_hsa05032	0.36734115
93	Chemical carcinogenesis_Homo sapiens_hsa05204	0.36326721
94	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.36269934
95	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33715212
96	Olfactory transduction_Homo sapiens_hsa04740	0.33396815
97	Alcoholism_Homo sapiens_hsa05034	0.32589882
98	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.31468624
99	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.30012917
100	Collecting duct acid secretion_Homo sapiens_hsa04966	0.29924966

RPL21P121

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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