ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein K11-linked deubiquitination (GO:0035871)	7.42638551
2	behavioral response to nicotine (GO:0035095)	5.45817672
3	serotonin receptor signaling pathway (GO:0007210)	5.41742480
4	regulation of appetite (GO:0032098)	4.36509149
5	detection of light stimulus involved in visual perception (GO:0050908)	3.94707030
6	detection of light stimulus involved in sensory perception (GO:0050962)	3.94707030
7	protein-cofactor linkage (GO:0018065)	3.90322240
8	sulfation (GO:0051923)	3.87132844
9	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.72759621
10	cellular ketone body metabolic process (GO:0046950)	3.65174131
11	tryptophan catabolic process (GO:0006569)	3.65116611
12	indole-containing compound catabolic process (GO:0042436)	3.65116611
13	indolalkylamine catabolic process (GO:0046218)	3.65116611
14	cysteine metabolic process (GO:0006534)	3.58656739
15	piRNA metabolic process (GO:0034587)	3.58582313
16	activated T cell proliferation (GO:0050798)	3.54098493
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.54013524
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.54013524
19	NADH dehydrogenase complex assembly (GO:0010257)	3.54013524
20	hematopoietic stem cell proliferation (GO:0071425)	3.50840293
21	killing of cells of other organism (GO:0031640)	3.47330436
22	disruption of cells of other organism (GO:0044364)	3.47330436
23	negative regulation of mast cell activation (GO:0033004)	3.45915848
24	negative regulation of interleukin-8 production (GO:0032717)	3.44720183
25	ketone body metabolic process (GO:1902224)	3.41226327
26	startle response (GO:0001964)	3.35014930
27	glycerophospholipid catabolic process (GO:0046475)	3.34469128
28	response to pheromone (GO:0019236)	3.33280594
29	reflex (GO:0060004)	3.31451560
30	protein K63-linked deubiquitination (GO:0070536)	3.31036457
31	protein complex biogenesis (GO:0070271)	3.29895808
32	negative regulation of telomere maintenance (GO:0032205)	3.29265996
33	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.28885365
34	L-fucose catabolic process (GO:0042355)	3.28706382
35	fucose catabolic process (GO:0019317)	3.28706382
36	L-fucose metabolic process (GO:0042354)	3.28706382
37	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.19014833
38	interferon-gamma production (GO:0032609)	3.17292151
39	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.15406904
40	indolalkylamine metabolic process (GO:0006586)	3.11174383
41	thyroid hormone metabolic process (GO:0042403)	3.10602826
42	rRNA catabolic process (GO:0016075)	3.08102318
43	positive regulation of hair cycle (GO:0042635)	3.05914667
44	positive regulation of hair follicle development (GO:0051798)	3.05914667
45	synaptic transmission, cholinergic (GO:0007271)	3.05119066
46	chaperone-mediated protein transport (GO:0072321)	3.03765294
47	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.03545423
48	preassembly of GPI anchor in ER membrane (GO:0016254)	3.03392875
49	mitochondrial respiratory chain complex assembly (GO:0033108)	3.02370388
50	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.01592340
51	tryptophan metabolic process (GO:0006568)	2.98913045
52	centriole replication (GO:0007099)	2.98622355
53	platelet dense granule organization (GO:0060155)	2.97905291
54	cilium or flagellum-dependent cell motility (GO:0001539)	2.96305460
55	organic cation transport (GO:0015695)	2.95871745
56	epithelial cilium movement (GO:0003351)	2.95228470
57	regulation of action potential (GO:0098900)	2.93799131
58	negative regulation of circadian rhythm (GO:0042754)	2.93001348
59	regulation of hexokinase activity (GO:1903299)	2.91613677
60	regulation of glucokinase activity (GO:0033131)	2.91613677
61	protein K48-linked deubiquitination (GO:0071108)	2.90964780
62	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.87556752
63	maturation of 5.8S rRNA (GO:0000460)	2.85766416
64	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.84103414
65	ATP synthesis coupled proton transport (GO:0015986)	2.84103414
66	gamma-aminobutyric acid transport (GO:0015812)	2.81573062
67	behavioral response to ethanol (GO:0048149)	2.78302060
68	defense response to fungus (GO:0050832)	2.77144459
69	DNA methylation involved in gamete generation (GO:0043046)	2.77090236
70	axon ensheathment in central nervous system (GO:0032291)	2.72266555
71	central nervous system myelination (GO:0022010)	2.72266555
72	N-acetylglucosamine metabolic process (GO:0006044)	2.71211459
73	retinal cone cell development (GO:0046549)	2.69117143
74	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.68812960
75	neuronal action potential (GO:0019228)	2.67698680
76	nonmotile primary cilium assembly (GO:0035058)	2.66475874
77	kynurenine metabolic process (GO:0070189)	2.64833565
78	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.64499785
79	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.64499785
80	neural tube formation (GO:0001841)	2.63268706
81	male meiosis (GO:0007140)	2.62952936
82	base-excision repair, AP site formation (GO:0006285)	2.62862489
83	nephron epithelium morphogenesis (GO:0072088)	2.62814952
84	nephron tubule morphogenesis (GO:0072078)	2.62814952
85	lymphangiogenesis (GO:0001946)	2.62409402
86	protein polyglutamylation (GO:0018095)	2.62333191
87	angiogenesis involved in wound healing (GO:0060055)	2.62161426
88	cellular biogenic amine catabolic process (GO:0042402)	2.60040701
89	amine catabolic process (GO:0009310)	2.60040701
90	DNA double-strand break processing (GO:0000729)	2.58213152
91	DNA deamination (GO:0045006)	2.57321781
92	peptidyl-histidine modification (GO:0018202)	2.55859310
93	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.52756490
94	proton transport (GO:0015992)	2.52146128
95	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.51310727
96	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.51294593
97	regulation of Cdc42 GTPase activity (GO:0043088)	2.51152080
98	indole-containing compound metabolic process (GO:0042430)	2.49595954
99	positive regulation of cAMP-mediated signaling (GO:0043950)	2.48892140
100	hydrogen transport (GO:0006818)	2.47874755

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.92611504
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.69013540
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.39018610
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.01942192
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.75003577
6	VDR_22108803_ChIP-Seq_LS180_Human	2.71585884
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.55822569
8	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.34799460
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.31793261
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.29525552
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.07911334
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.05517774
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.05304498
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03777058
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.02925651
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.99698927
17	EWS_26573619_Chip-Seq_HEK293_Human	1.89007250
18	TP53_22573176_ChIP-Seq_HFKS_Human	1.84586440
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79675816
20	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.77755276
21	P300_19829295_ChIP-Seq_ESCs_Human	1.76647900
22	FUS_26573619_Chip-Seq_HEK293_Human	1.74626340
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62976409
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.61882449
25	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57451167
26	AR_21572438_ChIP-Seq_LNCaP_Human	1.56475712
27	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.55811022
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53021819
29	AR_25329375_ChIP-Seq_VCAP_Human	1.52373042
30	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.52177322
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.51707528
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.50541981
33	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.50122330
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.45772316
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.44225142
36	REST_21632747_ChIP-Seq_MESCs_Mouse	1.43721269
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.42097148
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.41048100
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40095818
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.40095818
41	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.37288647
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33648676
43	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33648676
44	DROSHA_22980978_ChIP-Seq_HELA_Human	1.31655032
45	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.31067523
46	TCF4_23295773_ChIP-Seq_U87_Human	1.30159306
47	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29731737
48	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29332774
49	STAT3_23295773_ChIP-Seq_U87_Human	1.25819176
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.25421780
51	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.22167838
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22134620
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22134620
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20204420
55	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.20151238
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.16992796
57	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.16787367
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16427732
59	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.16388024
60	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16221415
61	NCOR_22424771_ChIP-Seq_293T_Human	1.16118228
62	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.15382514
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14759758
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14168228
65	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.14057905
66	ERA_21632823_ChIP-Seq_H3396_Human	1.14017686
67	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13837458
68	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.10763948
69	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.10625301
70	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10074551
71	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.09889836
72	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.09826673
73	HOXB7_26014856_ChIP-Seq_BT474_Human	1.09483491
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08567696
75	AR_20517297_ChIP-Seq_VCAP_Human	1.08241665
76	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.07984637
77	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.06290989
78	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.05942919
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05898473
80	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.05137101
81	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04679125
82	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.04465785
83	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04411773
84	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.03993072
85	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.03215135
86	MYC_19829295_ChIP-Seq_ESCs_Human	1.02992769
87	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.98922283
88	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.97549432
89	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.97377645
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97338829
91	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.97183777
92	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97050646
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95301636
94	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.94510008
95	TP53_16413492_ChIP-PET_HCT116_Human	0.93921487
96	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.93570465
97	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.93387553
98	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.93031676
99	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.91034219
100	JUN_21703547_ChIP-Seq_K562_Human	0.90790533

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	3.19980872
2	MP0003183_abnormal_peptide_metabolism	2.81047388
3	MP0005551_abnormal_eye_electrophysiolog	2.74453483
4	MP0004043_abnormal_pH_regulation	2.63602353
5	MP0005670_abnormal_white_adipose	2.54995323
6	MP0008877_abnormal_DNA_methylation	2.41625491
7	MP0002102_abnormal_ear_morphology	2.32216417
8	MP0004142_abnormal_muscle_tone	2.31105361
9	MP0003136_yellow_coat_color	2.21293647
10	MP0001984_abnormal_olfaction	2.21266502
11	MP0002138_abnormal_hepatobiliary_system	1.96641929
12	MP0009046_muscle_twitch	1.95087767
13	MP0001968_abnormal_touch/_nociception	1.93780878
14	MP0009745_abnormal_behavioral_response	1.92696044
15	MP0002876_abnormal_thyroid_physiology	1.89606341
16	MP0001986_abnormal_taste_sensitivity	1.86558656
17	MP0003195_calcinosis	1.85234799
18	MP0001919_abnormal_reproductive_system	1.80944140
19	MP0006276_abnormal_autonomic_nervous	1.78406093
20	MP0005389_reproductive_system_phenotype	1.72782843
21	MP0002653_abnormal_ependyma_morphology	1.72330335
22	MP0000372_irregular_coat_pigmentation	1.71771141
23	MP0002736_abnormal_nociception_after	1.67570679
24	MP0008872_abnormal_physiological_respon	1.66291539
25	MP0000569_abnormal_digit_pigmentation	1.65965413
26	MP0001486_abnormal_startle_reflex	1.64958602
27	MP0003646_muscle_fatigue	1.64736374
28	MP0006292_abnormal_olfactory_placode	1.64586047
29	MP0002272_abnormal_nervous_system	1.60444678
30	MP0002064_seizures	1.59041773
31	MP0005084_abnormal_gallbladder_morpholo	1.58478274
32	MP0002735_abnormal_chemical_nociception	1.56814031
33	MP0001905_abnormal_dopamine_level	1.55272973
34	MP0001529_abnormal_vocalization	1.53595596
35	MP0004147_increased_porphyrin_level	1.51803935
36	MP0005083_abnormal_biliary_tract	1.51749506
37	MP0004885_abnormal_endolymph	1.51589520
38	MP0005253_abnormal_eye_physiology	1.51441528
39	MP0006072_abnormal_retinal_apoptosis	1.43810133
40	MP0002837_dystrophic_cardiac_calcinosis	1.42771658
41	MP0003787_abnormal_imprinting	1.41193886
42	MP0005645_abnormal_hypothalamus_physiol	1.41123821
43	MP0003878_abnormal_ear_physiology	1.39766677
44	MP0005377_hearing/vestibular/ear_phenot	1.39766677
45	MP0002572_abnormal_emotion/affect_behav	1.38503629
46	MP0005310_abnormal_salivary_gland	1.37840020
47	MP0002638_abnormal_pupillary_reflex	1.37716526
48	MP0002928_abnormal_bile_duct	1.35344007
49	MP0000631_abnormal_neuroendocrine_gland	1.32653038
50	MP0002160_abnormal_reproductive_system	1.30549210
51	MP0001970_abnormal_pain_threshold	1.26229700
52	MP0004742_abnormal_vestibular_system	1.23958788
53	MP0008961_abnormal_basal_metabolism	1.22469954
54	MP0003806_abnormal_nucleotide_metabolis	1.21637258
55	MP0004133_heterotaxia	1.19318834
56	MP0002277_abnormal_respiratory_mucosa	1.18037615
57	MP0000230_abnormal_systemic_arterial	1.17314725
58	MP0004145_abnormal_muscle_electrophysio	1.17020724
59	MP0001501_abnormal_sleep_pattern	1.16928441
60	MP0001485_abnormal_pinna_reflex	1.15375266
61	MP0003880_abnormal_central_pattern	1.14191131
62	MP0009379_abnormal_foot_pigmentation	1.09533678
63	MP0003252_abnormal_bile_duct	1.09131234
64	MP0005085_abnormal_gallbladder_physiolo	1.07542270
65	MP0002557_abnormal_social/conspecific_i	1.05174434
66	MP0005195_abnormal_posterior_eye	1.04903610
67	MP0002938_white_spotting	1.03425370
68	MP0002234_abnormal_pharynx_morphology	1.03237690
69	MP0000427_abnormal_hair_cycle	1.02513447
70	MP0002734_abnormal_mechanical_nocicepti	1.01427939
71	MP0005646_abnormal_pituitary_gland	1.01054481
72	MP0005187_abnormal_penis_morphology	0.99713553
73	MP0005365_abnormal_bile_salt	0.99109680
74	MP0002067_abnormal_sensory_capabilities	0.98816712
75	MP0002063_abnormal_learning/memory/cond	0.98037805
76	MP0005174_abnormal_tail_pigmentation	0.97694561
77	MP0002909_abnormal_adrenal_gland	0.97098755
78	MP0000026_abnormal_inner_ear	0.96657029
79	MP0008058_abnormal_DNA_repair	0.95931902
80	MP0002733_abnormal_thermal_nociception	0.92473818
81	MP0008995_early_reproductive_senescence	0.89446540
82	MP0003635_abnormal_synaptic_transmissio	0.88980175
83	MP0008789_abnormal_olfactory_epithelium	0.88544693
84	MP0003283_abnormal_digestive_organ	0.87069703
85	MP0005171_absent_coat_pigmentation	0.85519424
86	MP0002752_abnormal_somatic_nervous	0.85244019
87	MP0004924_abnormal_behavior	0.85046929
88	MP0005386_behavior/neurological_phenoty	0.85046929
89	MP0002095_abnormal_skin_pigmentation	0.84970633
90	MP0005167_abnormal_blood-brain_barrier	0.84405545
91	MP0001324_abnormal_eye_pigmentation	0.84284905
92	MP0002254_reproductive_system_inflammat	0.83576645
93	MP0005647_abnormal_sex_gland	0.82017948
94	MP0000383_abnormal_hair_follicle	0.81916261
95	MP0010329_abnormal_lipoprotein_level	0.81829551
96	MP0002822_catalepsy	0.80971160
97	MP0002229_neurodegeneration	0.80129783
98	MP0002210_abnormal_sex_determination	0.79921311
99	MP0005332_abnormal_amino_acid	0.79702143
100	MP0003638_abnormal_response/metabolism_	0.79164656

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	5.15538897
2	Pancreatic cysts (HP:0001737)	4.01008544
3	Molar tooth sign on MRI (HP:0002419)	3.92988158
4	Abnormality of midbrain morphology (HP:0002418)	3.92988158
5	True hermaphroditism (HP:0010459)	3.86722753
6	Pancreatic fibrosis (HP:0100732)	3.55818528
7	Nephronophthisis (HP:0000090)	3.17425572
8	Abolished electroretinogram (ERG) (HP:0000550)	3.14057311
9	Type II lissencephaly (HP:0007260)	3.12352071
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.11815400
11	Attenuation of retinal blood vessels (HP:0007843)	3.00319602
12	Abnormal drinking behavior (HP:0030082)	2.95933632
13	Polydipsia (HP:0001959)	2.95933632
14	Congenital sensorineural hearing impairment (HP:0008527)	2.90170745
15	Abnormality of the renal cortex (HP:0011035)	2.88224393
16	Abnormality of the renal medulla (HP:0100957)	2.76230291
17	Lipid accumulation in hepatocytes (HP:0006561)	2.66015779
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.61334213
19	Bony spicule pigmentary retinopathy (HP:0007737)	2.57716760
20	Absent/shortened dynein arms (HP:0200106)	2.56960940
21	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.56960940
22	Tubular atrophy (HP:0000092)	2.55154803
23	Polyuria (HP:0000103)	2.52764933
24	Congenital, generalized hypertrichosis (HP:0004540)	2.51868205
25	Abnormal number of erythroid precursors (HP:0012131)	2.50624849
26	Medial flaring of the eyebrow (HP:0010747)	2.48002484
27	Chronic hepatic failure (HP:0100626)	2.47865873
28	Mitochondrial inheritance (HP:0001427)	2.44640656
29	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.38790529
30	Male pseudohermaphroditism (HP:0000037)	2.37884244
31	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.35705336
32	Cystic liver disease (HP:0006706)	2.34854849
33	Large for gestational age (HP:0001520)	2.33918468
34	Acute necrotizing encephalopathy (HP:0006965)	2.33729631
35	Abnormality of cells of the erythroid lineage (HP:0012130)	2.31884801
36	Decreased circulating renin level (HP:0003351)	2.30954190
37	Bile duct proliferation (HP:0001408)	2.30933984
38	Abnormal biliary tract physiology (HP:0012439)	2.30933984
39	Acute encephalopathy (HP:0006846)	2.28827744
40	Increased CSF lactate (HP:0002490)	2.27273594
41	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.26306333
42	Abnormality of alanine metabolism (HP:0010916)	2.26306333
43	Hyperalaninemia (HP:0003348)	2.26306333
44	Hyperventilation (HP:0002883)	2.25388591
45	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.23821978
46	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.22114604
47	Concave nail (HP:0001598)	2.17868499
48	Hyperglycinuria (HP:0003108)	2.12171490
49	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.11444601
50	Renal cortical cysts (HP:0000803)	2.10892831
51	Gait imbalance (HP:0002141)	2.10030092
52	Increased hepatocellular lipid droplets (HP:0006565)	2.08988410
53	Renal Fanconi syndrome (HP:0001994)	2.08959116
54	Optic nerve hypoplasia (HP:0000609)	2.08854213
55	Lissencephaly (HP:0001339)	2.08099683
56	Abnormal respiratory motile cilium morphology (HP:0005938)	2.06935747
57	Abnormal respiratory epithelium morphology (HP:0012253)	2.06935747
58	Hepatocellular necrosis (HP:0001404)	2.06273805
59	Abnormal urine output (HP:0012590)	2.06055732
60	Sclerocornea (HP:0000647)	2.05335986
61	Pendular nystagmus (HP:0012043)	2.03744882
62	Absent speech (HP:0001344)	2.03547991
63	Abnormal pancreas size (HP:0012094)	2.01341306
64	Hepatic necrosis (HP:0002605)	2.00566986
65	Inability to walk (HP:0002540)	2.00459666
66	Congenital primary aphakia (HP:0007707)	2.00352776
67	Decreased central vision (HP:0007663)	1.99443620
68	Retinal dysplasia (HP:0007973)	1.97953940
69	Optic disc pallor (HP:0000543)	1.97025197
70	Nephrogenic diabetes insipidus (HP:0009806)	1.97018468
71	Constricted visual fields (HP:0001133)	1.96694020
72	Mesangial abnormality (HP:0001966)	1.95635619
73	Abnormality of urine glucose concentration (HP:0011016)	1.92662552
74	Glycosuria (HP:0003076)	1.92662552
75	Progressive macrocephaly (HP:0004481)	1.92629459
76	Progressive inability to walk (HP:0002505)	1.90959384
77	Asplenia (HP:0001746)	1.89280429
78	Pachygyria (HP:0001302)	1.88233752
79	Severe muscular hypotonia (HP:0006829)	1.86184323
80	Congenital hepatic fibrosis (HP:0002612)	1.86170199
81	Retrobulbar optic neuritis (HP:0100654)	1.85804135
82	Optic neuritis (HP:0100653)	1.85804135
83	Hypoplasia of the uterus (HP:0000013)	1.85251152
84	Abnormal mitochondria in muscle tissue (HP:0008316)	1.82942286
85	Abnormal ciliary motility (HP:0012262)	1.82513458
86	Clumsiness (HP:0002312)	1.82222001
87	3-Methylglutaconic aciduria (HP:0003535)	1.81069709
88	Hyperglycinemia (HP:0002154)	1.80872462
89	Anencephaly (HP:0002323)	1.79988787
90	Retinitis pigmentosa (HP:0000510)	1.79864297
91	Aplasia/hypoplasia of the uterus (HP:0008684)	1.78884118
92	Furrowed tongue (HP:0000221)	1.78067700
93	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.77961861
94	Absent thumb (HP:0009777)	1.77865992
95	Abnormality of the ileum (HP:0001549)	1.77544302
96	Bilateral microphthalmos (HP:0007633)	1.76892798
97	Febrile seizures (HP:0002373)	1.76159385
98	Genital tract atresia (HP:0001827)	1.75863507
99	Meckel diverticulum (HP:0002245)	1.74954392
100	Focal motor seizures (HP:0011153)	1.73838517

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.76036831
2	WNK3	4.32734091
3	ADRBK2	3.68226505
4	PINK1	3.27446235
5	TXK	2.87268048
6	GRK1	2.72289435
7	WNK4	2.66458309
8	ZAK	2.54329859
9	TAOK3	2.23834323
10	BMPR1B	2.11071306
11	MAP4K2	1.98854471
12	NUAK1	1.94294443
13	MAPK13	1.91837434
14	NEK2	1.89304806
15	CCNB1	1.83575848
16	DYRK2	1.66804614
17	CASK	1.61282436
18	TLK1	1.60671161
19	OXSR1	1.44673408
20	NTRK3	1.40076243
21	INSRR	1.39448930
22	ADRBK1	1.32653386
23	STK39	1.31560268
24	BCKDK	1.25533633
25	CAMKK2	1.22433361
26	MAP3K4	1.20579005
27	BLK	1.13966756
28	PIK3CA	1.05969216
29	MAPKAPK5	1.05578521
30	MAPKAPK3	1.03935599
31	MAPK15	0.99674196
32	MARK1	0.97119148
33	TAF1	0.96941236
34	DAPK2	0.91372397
35	MAP2K7	0.89765313
36	PAK3	0.87698612
37	NEK1	0.87440316
38	VRK2	0.85265840
39	TIE1	0.81826191
40	PLK4	0.79859851
41	KIT	0.77618364
42	MUSK	0.77461108
43	VRK1	0.76704684
44	PRKCG	0.76512877
45	CAMK1	0.74824381
46	LIMK1	0.73946372
47	PRKCZ	0.73248295
48	GRK7	0.70271758
49	MARK3	0.68137236
50	PRKCE	0.66864004
51	TRIM28	0.66463899
52	STK16	0.64887445
53	GRK5	0.63819543
54	MKNK2	0.61884935
55	MAP2K2	0.59076140
56	NTRK2	0.58676591
57	IKBKB	0.58154725
58	ACVR1B	0.58132509
59	MAP2K6	0.57971841
60	ERBB3	0.57824229
61	TGFBR1	0.57784330
62	PRKACA	0.56616514
63	FLT3	0.56357481
64	AKT3	0.54918928
65	CAMK1D	0.54398901
66	CAMK2A	0.54019938
67	CSNK1G2	0.54010436
68	IRAK1	0.53851072
69	CSNK1G3	0.53659098
70	RPS6KA5	0.52666863
71	CDK19	0.49429758
72	PKN1	0.48697316
73	CHEK2	0.48458790
74	STK38L	0.46931118
75	CHUK	0.46485341
76	PRKCA	0.45255515
77	MKNK1	0.45119281
78	IRAK4	0.45032069
79	IKBKE	0.44423062
80	SYK	0.43219431
81	STK11	0.43212025
82	NME1	0.42653345
83	BRSK2	0.42606353
84	EIF2AK2	0.42552472
85	CSNK1A1L	0.42098508
86	PHKG1	0.40997863
87	PHKG2	0.40997863
88	CSNK1A1	0.40846748
89	MAP2K1	0.40821699
90	PRKCQ	0.40705696
91	PRKG1	0.40408214
92	CSF1R	0.39420430
93	PTK2B	0.38861722
94	OBSCN	0.38238911
95	PRKCI	0.38042567
96	CSNK1G1	0.37243373
97	WEE1	0.33331351
98	IGF1R	0.32766759
99	SIK2	0.32215516
100	FER	0.31860238

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	2.89817328
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.88562954
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.86348669
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.75313492
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.68402124
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.58516476
7	Phototransduction_Homo sapiens_hsa04744	2.44829158
8	Butanoate metabolism_Homo sapiens_hsa00650	2.36690552
9	Parkinsons disease_Homo sapiens_hsa05012	2.34574042
10	Nicotine addiction_Homo sapiens_hsa05033	2.27686863
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.19950440
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.12175811
13	Ribosome_Homo sapiens_hsa03010	2.01643913
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.93987561
15	Ether lipid metabolism_Homo sapiens_hsa00565	1.93012700
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.89528144
17	Homologous recombination_Homo sapiens_hsa03440	1.72644685
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.65092443
19	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.58572214
20	Huntingtons disease_Homo sapiens_hsa05016	1.56347728
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.55020069
22	Alzheimers disease_Homo sapiens_hsa05010	1.50544453
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.49559709
24	Asthma_Homo sapiens_hsa05310	1.47475914
25	Proteasome_Homo sapiens_hsa03050	1.43934319
26	Olfactory transduction_Homo sapiens_hsa04740	1.41837911
27	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.40590891
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.40481303
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.40345251
30	Propanoate metabolism_Homo sapiens_hsa00640	1.32629257
31	RNA polymerase_Homo sapiens_hsa03020	1.31258943
32	Basal transcription factors_Homo sapiens_hsa03022	1.30484462
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.30457103
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.27094023
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.25622719
36	Morphine addiction_Homo sapiens_hsa05032	1.24839132
37	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.24024928
38	Caffeine metabolism_Homo sapiens_hsa00232	1.21991343
39	Fat digestion and absorption_Homo sapiens_hsa04975	1.20213256
40	Serotonergic synapse_Homo sapiens_hsa04726	1.18684502
41	Taste transduction_Homo sapiens_hsa04742	1.11421149
42	Peroxisome_Homo sapiens_hsa04146	1.08956563
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.08694688
44	Protein export_Homo sapiens_hsa03060	1.06571196
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.01365781
46	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.99937089
47	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.99888368
48	Histidine metabolism_Homo sapiens_hsa00340	0.98677205
49	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.94983259
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.94541325
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.91237278
52	GABAergic synapse_Homo sapiens_hsa04727	0.89636411
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88936865
54	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.88220162
55	Calcium signaling pathway_Homo sapiens_hsa04020	0.87836901
56	Sulfur relay system_Homo sapiens_hsa04122	0.86993725
57	One carbon pool by folate_Homo sapiens_hsa00670	0.85316670
58	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.85224299
59	Type I diabetes mellitus_Homo sapiens_hsa04940	0.83112026
60	Graft-versus-host disease_Homo sapiens_hsa05332	0.82329815
61	Allograft rejection_Homo sapiens_hsa05330	0.82262323
62	Primary immunodeficiency_Homo sapiens_hsa05340	0.79093963
63	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.76745506
64	Salivary secretion_Homo sapiens_hsa04970	0.76350666
65	Glycerolipid metabolism_Homo sapiens_hsa00561	0.75086415
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.74297226
67	Metabolic pathways_Homo sapiens_hsa01100	0.71637351
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70912711
69	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.69208811
70	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.65828914
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63671041
72	RNA degradation_Homo sapiens_hsa03018	0.63010824
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61897809
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59340464
75	Fatty acid degradation_Homo sapiens_hsa00071	0.56223408
76	Rheumatoid arthritis_Homo sapiens_hsa05323	0.54049460
77	Pyrimidine metabolism_Homo sapiens_hsa00240	0.54007300
78	Circadian entrainment_Homo sapiens_hsa04713	0.53514473
79	Retinol metabolism_Homo sapiens_hsa00830	0.53360382
80	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.53046582
81	ABC transporters_Homo sapiens_hsa02010	0.52598625
82	Purine metabolism_Homo sapiens_hsa00230	0.48901747
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.48492693
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46733205
85	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.45351924
86	Glutamatergic synapse_Homo sapiens_hsa04724	0.42549407
87	Insulin secretion_Homo sapiens_hsa04911	0.42169033
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.41982748
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41220341
90	cAMP signaling pathway_Homo sapiens_hsa04024	0.40394272
91	Fatty acid metabolism_Homo sapiens_hsa01212	0.39153118
92	Regulation of autophagy_Homo sapiens_hsa04140	0.38492558
93	Glutathione metabolism_Homo sapiens_hsa00480	0.37447644
94	Cholinergic synapse_Homo sapiens_hsa04725	0.36587226
95	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.36352677
96	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.35842191
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.35508682
98	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.35001418
99	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.33824847
100	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.33027219

RPL21P122

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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