ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.57184736
2	behavioral response to nicotine (GO:0035095)	4.38703237
3	NAD biosynthetic process (GO:0009435)	3.96853463
4	neuron fate determination (GO:0048664)	3.80152284
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.52021031
6	ATP synthesis coupled proton transport (GO:0015986)	3.52021031
7	negative regulation of mast cell activation (GO:0033004)	3.39616368
8	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.25803729
9	regulation of female receptivity (GO:0045924)	3.23148766
10	fucose catabolic process (GO:0019317)	3.22668782
11	L-fucose metabolic process (GO:0042354)	3.22668782
12	L-fucose catabolic process (GO:0042355)	3.22668782
13	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.16671644
14	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.11502873
15	indolalkylamine metabolic process (GO:0006586)	3.09198412
16	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.07049028
17	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.03801999
18	platelet dense granule organization (GO:0060155)	2.98797521
19	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.91599843
20	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.91325412
21	mast cell activation (GO:0045576)	2.88726179
22	interferon-gamma production (GO:0032609)	2.87258209
23	nicotinamide nucleotide biosynthetic process (GO:0019359)	2.81774565
24	pyridine nucleotide biosynthetic process (GO:0019363)	2.81774565
25	cellular response to interleukin-15 (GO:0071350)	2.81643327
26	positive regulation of defense response to virus by host (GO:0002230)	2.80534100
27	prenylation (GO:0097354)	2.77183445
28	protein prenylation (GO:0018342)	2.77183445
29	activated T cell proliferation (GO:0050798)	2.76844061
30	protein neddylation (GO:0045116)	2.75864703
31	female mating behavior (GO:0060180)	2.71862826
32	neural tube formation (GO:0001841)	2.70579175
33	purine-containing compound salvage (GO:0043101)	2.70122858
34	response to interferon-beta (GO:0035456)	2.66593729
35	microglial cell activation (GO:0001774)	2.66143245
36	somite development (GO:0061053)	2.66001781
37	positive regulation of interleukin-17 production (GO:0032740)	2.65482881
38	sequestering of actin monomers (GO:0042989)	2.65180152
39	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.64772344
40	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.61110535
41	positive regulation of mast cell degranulation (GO:0043306)	2.61110535
42	protein-cofactor linkage (GO:0018065)	2.61105439
43	regulation of regulatory T cell differentiation (GO:0045589)	2.60872199
44	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.60639567
45	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.60366450
46	positive regulation of fatty acid transport (GO:2000193)	2.58691923
47	cellular response to interferon-beta (GO:0035458)	2.58651961
48	protein polyglutamylation (GO:0018095)	2.57570913
49	positive regulation of mast cell activation (GO:0033005)	2.56170581
50	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	2.55546304
51	toxin metabolic process (GO:0009404)	2.54754757
52	electron transport chain (GO:0022900)	2.54634544
53	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.51647546
54	protein complex biogenesis (GO:0070271)	2.51506138
55	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.50381354
56	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.50381354
57	regulation of immunoglobulin secretion (GO:0051023)	2.49745884
58	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.48770812
59	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.48384645
60	respiratory electron transport chain (GO:0022904)	2.47306660
61	regulation of interleukin-6 biosynthetic process (GO:0045408)	2.46271107
62	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.45562871
63	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.45562871
64	NADH dehydrogenase complex assembly (GO:0010257)	2.45562871
65	GPI anchor metabolic process (GO:0006505)	2.44828544
66	tryptophan catabolic process (GO:0006569)	2.43406586
67	indole-containing compound catabolic process (GO:0042436)	2.43406586
68	indolalkylamine catabolic process (GO:0046218)	2.43406586
69	GTP biosynthetic process (GO:0006183)	2.42522933
70	positive regulation of prostaglandin secretion (GO:0032308)	2.42344145
71	cAMP catabolic process (GO:0006198)	2.41678118
72	negative regulation of telomere maintenance (GO:0032205)	2.40518838
73	respiratory chain complex IV assembly (GO:0008535)	2.38374547
74	ribosomal small subunit assembly (GO:0000028)	2.37385788
75	regulation of mitotic spindle checkpoint (GO:1903504)	2.37150089
76	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.37150089
77	N-acetylglucosamine metabolic process (GO:0006044)	2.35512384
78	double-strand break repair via homologous recombination (GO:0000724)	2.35487369
79	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.35069990
80	behavioral response to ethanol (GO:0048149)	2.33627972
81	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.33279565
82	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.33279565
83	isotype switching (GO:0045190)	2.33279565
84	tryptophan metabolic process (GO:0006568)	2.32932080
85	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.32204248
86	protein K6-linked ubiquitination (GO:0085020)	2.30983732
87	regulation of mesoderm development (GO:2000380)	2.30821928
88	mitochondrial respiratory chain complex assembly (GO:0033108)	2.29832108
89	positive regulation of icosanoid secretion (GO:0032305)	2.29723697
90	recombinational repair (GO:0000725)	2.29149875
91	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.28784973
92	tolerance induction (GO:0002507)	2.28323068
93	positive regulation of B cell mediated immunity (GO:0002714)	2.27892504
94	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.27892504
95	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.27674606
96	response to interleukin-15 (GO:0070672)	2.27086362
97	S-adenosylmethionine metabolic process (GO:0046500)	2.26302391
98	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.25847128
99	piRNA metabolic process (GO:0034587)	2.24320619
100	regulation of mast cell activation (GO:0033003)	2.23376460

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.87168255
2	ZNF274_21170338_ChIP-Seq_K562_Hela	2.84164279
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.78327766
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.71366266
5	VDR_22108803_ChIP-Seq_LS180_Human	2.63871507
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.42855451
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.42239703
8	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.40496886
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.33715741
10	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.31867024
11	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.25651632
12	FUS_26573619_Chip-Seq_HEK293_Human	2.12272341
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.11259139
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.08208856
15	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.03554642
16	EWS_26573619_Chip-Seq_HEK293_Human	2.02495195
17	GBX2_23144817_ChIP-Seq_PC3_Human	1.97991689
18	P300_19829295_ChIP-Seq_ESCs_Human	1.97579697
19	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.93310807
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.91995618
21	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.88464291
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.83877405
23	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.82809157
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.80784431
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.72737688
26	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.69332013
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.67377410
28	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.63470297
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.60742148
30	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.60644831
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.59319629
32	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.59240187
33	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.54570878
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.52939740
35	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.52268645
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52068575
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50730510
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.50327575
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.47341396
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.47341396
41	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46196511
42	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.46196511
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.45681712
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.42672896
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42672896
46	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42620733
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42404156
48	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.41470457
49	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.37833362
50	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.36070224
51	STAT3_23295773_ChIP-Seq_U87_Human	1.34935218
52	GATA3_26560356_Chip-Seq_TH2_Human	1.33908604
53	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.33867259
54	TCF4_23295773_ChIP-Seq_U87_Human	1.32792450
55	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.32359855
56	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.31036722
57	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.31003450
58	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.29883249
59	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.29547647
60	P53_22387025_ChIP-Seq_ESCs_Mouse	1.28975291
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.27350396
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.25257085
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24649624
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24649624
65	AR_20517297_ChIP-Seq_VCAP_Human	1.24499208
66	SMAD4_21799915_ChIP-Seq_A2780_Human	1.24375779
67	VDR_23849224_ChIP-Seq_CD4+_Human	1.23377874
68	BCAT_22108803_ChIP-Seq_LS180_Human	1.23279383
69	AR_21572438_ChIP-Seq_LNCaP_Human	1.23258463
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.22943733
71	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.22612407
72	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.22367549
73	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21494984
74	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.21476537
75	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.20258284
76	AR_25329375_ChIP-Seq_VCAP_Human	1.18121610
77	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17332528
78	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16931760
79	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16445052
80	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.16415621
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.15421197
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15279058
83	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.14344718
84	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13602914
85	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.13396857
86	RUNX_20019798_ChIP-Seq_JUKART_Human	1.12484520
87	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.12348840
88	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.12091451
89	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12082112
90	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.11633458
91	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11434734
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11100764
93	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10701364
94	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09557007
95	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09136882
96	MYC_18940864_ChIP-ChIP_HL60_Human	1.09087230
97	HTT_18923047_ChIP-ChIP_STHdh_Human	1.08512598
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.07740167
99	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07246080
100	ELK1_19687146_ChIP-ChIP_HELA_Human	1.06119320

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.49989962
2	MP0000372_irregular_coat_pigmentation	3.37937918
3	MP0001835_abnormal_antigen_presentation	3.25494362
4	MP0008877_abnormal_DNA_methylation	2.99887011
5	MP0000685_abnormal_immune_system	2.81389946
6	MP0002876_abnormal_thyroid_physiology	2.54737674
7	MP0003136_yellow_coat_color	2.54373997
8	MP0004885_abnormal_endolymph	2.42338403
9	MP0003724_increased_susceptibility_to	2.30698410
10	MP0004147_increased_porphyrin_level	2.26315436
11	MP0006072_abnormal_retinal_apoptosis	2.23654650
12	MP0005671_abnormal_response_to	2.13370330
13	MP0005075_abnormal_melanosome_morpholog	2.08018039
14	MP0003195_calcinosis	1.99563135
15	MP0004381_abnormal_hair_follicle	1.96284418
16	MP0008875_abnormal_xenobiotic_pharmacok	1.94827533
17	MP0004142_abnormal_muscle_tone	1.88175463
18	MP0002102_abnormal_ear_morphology	1.85052638
19	MP0001800_abnormal_humoral_immune	1.84881929
20	MP0003646_muscle_fatigue	1.81405580
21	MP0009785_altered_susceptibility_to	1.80262176
22	MP0003787_abnormal_imprinting	1.65312746
23	MP0005387_immune_system_phenotype	1.62293974
24	MP0001790_abnormal_immune_system	1.62293974
25	MP0002148_abnormal_hypersensitivity_rea	1.57092927
26	MP0005253_abnormal_eye_physiology	1.54164346
27	MP0005551_abnormal_eye_electrophysiolog	1.53456413
28	MP0003011_delayed_dark_adaptation	1.48215009
29	MP0001968_abnormal_touch/_nociception	1.47498197
30	MP0002938_white_spotting	1.44309811
31	MP0005646_abnormal_pituitary_gland	1.44153527
32	MP0002132_abnormal_respiratory_system	1.43666313
33	MP0000383_abnormal_hair_follicle	1.38838419
34	MP0006292_abnormal_olfactory_placode	1.38114801
35	MP0004019_abnormal_vitamin_homeostasis	1.37699435
36	MP0009780_abnormal_chondrocyte_physiolo	1.31848461
37	MP0003786_premature_aging	1.31491448
38	MP0002723_abnormal_immune_serum	1.31064992
39	MP0002163_abnormal_gland_morphology	1.31032815
40	MP0004742_abnormal_vestibular_system	1.29961739
41	MP0001542_abnormal_bone_strength	1.26866297
42	MP0009046_muscle_twitch	1.26542680
43	MP0002736_abnormal_nociception_after	1.24507034
44	MP0002166_altered_tumor_susceptibility	1.22801420
45	MP0004043_abnormal_pH_regulation	1.20751318
46	MP0002452_abnormal_antigen_presenting	1.18175732
47	MP0005000_abnormal_immune_tolerance	1.17204866
48	MP0002638_abnormal_pupillary_reflex	1.13801304
49	MP0009764_decreased_sensitivity_to	1.13325071
50	MP0005503_abnormal_tendon_morphology	1.13008397
51	MP0001873_stomach_inflammation	1.11481279
52	MP0005645_abnormal_hypothalamus_physiol	1.10681901
53	MP0000427_abnormal_hair_cycle	1.10212333
54	MP0002420_abnormal_adaptive_immunity	1.09907890
55	MP0001486_abnormal_startle_reflex	1.09672233
56	MP0001819_abnormal_immune_cell	1.08655895
57	MP0001986_abnormal_taste_sensitivity	1.06171318
58	MP0005377_hearing/vestibular/ear_phenot	1.06150185
59	MP0003878_abnormal_ear_physiology	1.06150185
60	MP0009745_abnormal_behavioral_response	1.04163366
61	MP0005174_abnormal_tail_pigmentation	1.03842969
62	MP0001501_abnormal_sleep_pattern	1.03834113
63	MP0001919_abnormal_reproductive_system	1.02725860
64	MP0008995_early_reproductive_senescence	1.01014256
65	MP0005187_abnormal_penis_morphology	0.98422983
66	MP0000631_abnormal_neuroendocrine_gland	0.97480560
67	MP0006276_abnormal_autonomic_nervous	0.93265117
68	MP0002272_abnormal_nervous_system	0.91859825
69	MP0008872_abnormal_physiological_respon	0.90341187
70	MP0005025_abnormal_response_to	0.88151863
71	MP0001485_abnormal_pinna_reflex	0.87781906
72	MP0000716_abnormal_immune_system	0.87472891
73	MP0002006_tumorigenesis	0.86815973
74	MP0005408_hypopigmentation	0.85843997
75	MP0000689_abnormal_spleen_morphology	0.85486951
76	MP0003567_abnormal_fetal_cardiomyocyte	0.85347357
77	MP0003866_abnormal_defecation	0.85028972
78	MP0003763_abnormal_thymus_physiology	0.84241390
79	MP0003638_abnormal_response/metabolism_	0.84132405
80	MP0002693_abnormal_pancreas_physiology	0.83879016
81	MP0003880_abnormal_central_pattern	0.82446967
82	MP0005379_endocrine/exocrine_gland_phen	0.81444860
83	MP0000516_abnormal_urinary_system	0.80096239
84	MP0005367_renal/urinary_system_phenotyp	0.80096239
85	MP0002405_respiratory_system_inflammati	0.78941795
86	MP0010155_abnormal_intestine_physiology	0.77756730
87	MP0002837_dystrophic_cardiac_calcinosis	0.77551378
88	MP0002398_abnormal_bone_marrow	0.74417047
89	MP0005083_abnormal_biliary_tract	0.74070400
90	MP0004484_altered_response_of	0.69939491
91	MP0001533_abnormal_skeleton_physiology	0.69259774
92	MP0002419_abnormal_innate_immunity	0.68886972
93	MP0003718_maternal_effect	0.68389740
94	MP0006035_abnormal_mitochondrial_morpho	0.68025400
95	MP0001984_abnormal_olfaction	0.67687048
96	MP0001845_abnormal_inflammatory_respons	0.66977866
97	MP0002095_abnormal_skin_pigmentation	0.66953086
98	MP0003436_decreased_susceptibility_to	0.66888662
99	MP0000647_abnormal_sebaceous_gland	0.66510629
100	MP0002722_abnormal_immune_system	0.65980470

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Concave nail (HP:0001598)	3.94265254
2	3-Methylglutaconic aciduria (HP:0003535)	3.87867907
3	Attenuation of retinal blood vessels (HP:0007843)	3.81827982
4	Congenital stationary night blindness (HP:0007642)	3.71300859
5	Stomatitis (HP:0010280)	3.69322898
6	True hermaphroditism (HP:0010459)	3.53516421
7	Pancreatic cysts (HP:0001737)	3.39055689
8	Pancreatic fibrosis (HP:0100732)	3.18742785
9	Molar tooth sign on MRI (HP:0002419)	3.14555971
10	Abnormality of midbrain morphology (HP:0002418)	3.14555971
11	Nephronophthisis (HP:0000090)	3.13809016
12	Hypoproteinemia (HP:0003075)	3.10889540
13	Renal cortical cysts (HP:0000803)	3.09268056
14	IgG deficiency (HP:0004315)	3.07288283
15	Congenital, generalized hypertrichosis (HP:0004540)	3.03935431
16	Chronic hepatic failure (HP:0100626)	2.92348264
17	Metaphyseal dysplasia (HP:0100255)	2.91577329
18	Abnormality of the renal medulla (HP:0100957)	2.88372882
19	Optic disc pallor (HP:0000543)	2.83790022
20	Abnormality of the renal cortex (HP:0011035)	2.83605947
21	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.77272653
22	Absent/shortened dynein arms (HP:0200106)	2.77272653
23	Thyroid-stimulating hormone excess (HP:0002925)	2.76238531
24	Thyroiditis (HP:0100646)	2.66320738
25	Increased hepatocellular lipid droplets (HP:0006565)	2.64977750
26	Mitochondrial inheritance (HP:0001427)	2.58360393
27	Absent frontal sinuses (HP:0002688)	2.47970020
28	Lipid accumulation in hepatocytes (HP:0006561)	2.42809798
29	Elevated erythrocyte sedimentation rate (HP:0003565)	2.39214853
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.32299770
31	Hypothermia (HP:0002045)	2.30198167
32	Abnormal ciliary motility (HP:0012262)	2.28606619
33	Chronic mucocutaneous candidiasis (HP:0002728)	2.26599524
34	Recurrent cutaneous fungal infections (HP:0011370)	2.26599524
35	Type II lissencephaly (HP:0007260)	2.26199813
36	Abolished electroretinogram (ERG) (HP:0000550)	2.25128216
37	Progressive macrocephaly (HP:0004481)	2.24476556
38	Acute necrotizing encephalopathy (HP:0006965)	2.20711693
39	Acute encephalopathy (HP:0006846)	2.20596358
40	Constricted visual fields (HP:0001133)	2.20341867
41	Furrowed tongue (HP:0000221)	2.19723912
42	Abnormal respiratory epithelium morphology (HP:0012253)	2.19126066
43	Abnormal respiratory motile cilium morphology (HP:0005938)	2.19126066
44	Hypoplasia of the thymus (HP:0000778)	2.18465885
45	T lymphocytopenia (HP:0005403)	2.18414057
46	Abnormality of T cell number (HP:0011839)	2.17789086
47	Medial flaring of the eyebrow (HP:0010747)	2.17308496
48	Increased CSF lactate (HP:0002490)	2.13829711
49	Hypoplasia of the pons (HP:0012110)	2.13496009
50	Abnormality of the pons (HP:0007361)	2.12026364
51	Postaxial foot polydactyly (HP:0001830)	2.11885090
52	Exertional dyspnea (HP:0002875)	2.08741274
53	Keratoconjunctivitis (HP:0001096)	2.07491720
54	Chronic sinusitis (HP:0011109)	2.05822493
55	Fair hair (HP:0002286)	2.02278691
56	Abnormality of T cells (HP:0002843)	2.01777652
57	Visual hallucinations (HP:0002367)	2.00990220
58	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.00681439
59	Abnormality of the frontal sinuses (HP:0002687)	1.97873874
60	Cerebellar dysplasia (HP:0007033)	1.97643839
61	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.94966944
62	Conical tooth (HP:0000698)	1.94401527
63	Abnormality of renal resorption (HP:0011038)	1.89354301
64	Increased corneal curvature (HP:0100692)	1.89282391
65	Keratoconus (HP:0000563)	1.89282391
66	Renal Fanconi syndrome (HP:0001994)	1.88952535
67	Parakeratosis (HP:0001036)	1.87710538
68	Male pseudohermaphroditism (HP:0000037)	1.86090354
69	Alveolar cell carcinoma (HP:0006519)	1.84432051
70	Retrobulbar optic neuritis (HP:0100654)	1.83734935
71	Optic neuritis (HP:0100653)	1.83734935
72	Recurrent corneal erosions (HP:0000495)	1.82396859
73	Type 2 muscle fiber atrophy (HP:0003554)	1.82046013
74	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.81916587
75	Abnormality of urine glucose concentration (HP:0011016)	1.81252294
76	Glycosuria (HP:0003076)	1.81252294
77	Recurrent fungal infections (HP:0002841)	1.81229154
78	Short tibia (HP:0005736)	1.78336173
79	Abnormality of eosinophils (HP:0001879)	1.78037146
80	Congenital hepatic fibrosis (HP:0002612)	1.76450710
81	Decreased central vision (HP:0007663)	1.76154531
82	Neoplasm of the tracheobronchial system (HP:0100552)	1.75997612
83	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.75943953
84	Abnormal albumin level (HP:0012116)	1.75572509
85	Hypoalbuminemia (HP:0003073)	1.75572509
86	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.75556412
87	Spondylolisthesis (HP:0003302)	1.71456556
88	Delayed CNS myelination (HP:0002188)	1.70806476
89	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.70709010
90	Hypoplasia of the fovea (HP:0007750)	1.70709010
91	Abnormal mitochondria in muscle tissue (HP:0008316)	1.70302755
92	Keratoconjunctivitis sicca (HP:0001097)	1.70174476
93	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.69901856
94	Abnormality of alanine metabolism (HP:0010916)	1.69901856
95	Hyperalaninemia (HP:0003348)	1.69901856
96	Respiratory difficulties (HP:0002880)	1.68404980
97	Anencephaly (HP:0002323)	1.67916556
98	Hemiparesis (HP:0001269)	1.67013634
99	Oligodactyly (hands) (HP:0001180)	1.66197988
100	Encephalitis (HP:0002383)	1.65708161

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	5.17198212
2	FRK	4.34758872
3	TXK	3.62794271
4	TAOK3	3.35314479
5	ADRBK2	2.86548156
6	TLK1	2.53089550
7	WNK3	2.27001967
8	MAP4K2	2.06059322
9	PINK1	1.91694245
10	KIT	1.85969198
11	OXSR1	1.80541415
12	ZAK	1.77454465
13	GRK1	1.75196878
14	MAP4K1	1.69020957
15	MAP3K12	1.63702556
16	NUAK1	1.55509974
17	TAF1	1.49873183
18	WNK4	1.46243322
19	IKBKE	1.39360095
20	GRK6	1.35322984
21	PLK2	1.35245142
22	STK39	1.30855994
23	PAK3	1.28204283
24	MAP3K4	1.26008179
25	PIK3CG	1.19280410
26	IKBKB	1.14786216
27	MST4	1.14134871
28	SYK	1.13030551
29	MAP3K2	1.10423301
30	JAK3	1.08749122
31	BMPR2	1.04779283
32	NTRK3	1.04378521
33	BTK	1.04309485
34	TEC	1.03361659
35	CDK19	1.02646697
36	VRK1	1.02304920
37	NTRK2	0.98155916
38	EPHA3	0.97165372
39	ADRBK1	0.95834452
40	MAP2K7	0.90732431
41	BCKDK	0.84874540
42	ITK	0.84766989
43	LYN	0.83297573
44	ERBB2	0.76471765
45	FES	0.76065505
46	DYRK2	0.75977507
47	LCK	0.75969539
48	CCNB1	0.73244140
49	ZAP70	0.70847451
50	NLK	0.69375257
51	ACVR1B	0.67162710
52	TNIK	0.66360215
53	DAPK2	0.65920576
54	TYK2	0.65209777
55	OBSCN	0.63563257
56	FLT3	0.60881100
57	EIF2AK3	0.59953215
58	GRK5	0.59668831
59	EPHA4	0.59339222
60	CAMK1	0.59151199
61	CHUK	0.59116920
62	CDK8	0.57869896
63	CAMKK2	0.57473775
64	GRK7	0.57007768
65	MAP2K6	0.56418377
66	MARK3	0.56378303
67	CAMK1D	0.56334587
68	MATK	0.56177342
69	UHMK1	0.55933835
70	MAP3K6	0.55420520
71	MAP3K5	0.54138762
72	MAPK13	0.53578412
73	RPS6KA5	0.52689073
74	PRKCQ	0.51522638
75	WNK1	0.49319441
76	SIK2	0.49128435
77	CSF1R	0.48930917
78	MAP2K4	0.47473300
79	ERBB3	0.47354248
80	PTK2B	0.47030579
81	PIK3CA	0.47024607
82	SGK2	0.45285531
83	CAMK4	0.45168434
84	NME1	0.45032089
85	PRKG1	0.44791861
86	VRK2	0.43635822
87	PIM1	0.42821072
88	PLK3	0.42088811
89	EGFR	0.40833103
90	MAPK15	0.40545966
91	PRKCE	0.40519611
92	CSK	0.40418854
93	HCK	0.39772339
94	STK11	0.39544604
95	STK4	0.39432747
96	CDK3	0.38597459
97	IGF1R	0.36589257
98	BMPR1B	0.36452820
99	DYRK3	0.35041806
100	CSNK2A2	0.33008630

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.70095418
2	Asthma_Homo sapiens_hsa05310	3.37731830
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.91639833
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.73165871
5	Allograft rejection_Homo sapiens_hsa05330	2.55833569
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.45831048
7	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.36109904
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.30048069
9	Parkinsons disease_Homo sapiens_hsa05012	2.22676994
10	Caffeine metabolism_Homo sapiens_hsa00232	2.20288089
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.18261944
12	Primary immunodeficiency_Homo sapiens_hsa05340	2.05789545
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.82004645
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.75126990
15	Protein export_Homo sapiens_hsa03060	1.71874116
16	Ribosome_Homo sapiens_hsa03010	1.70929312
17	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.70366000
18	Phototransduction_Homo sapiens_hsa04744	1.70241631
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.68179933
20	Proteasome_Homo sapiens_hsa03050	1.68154769
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.64912467
22	Alzheimers disease_Homo sapiens_hsa05010	1.61695815
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.59143827
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.58037576
25	Basal transcription factors_Homo sapiens_hsa03022	1.57385117
26	Homologous recombination_Homo sapiens_hsa03440	1.56853302
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.54662067
28	RNA degradation_Homo sapiens_hsa03018	1.51815226
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.43199543
30	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.40279963
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.40278034
32	Nicotine addiction_Homo sapiens_hsa05033	1.37244611
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.31670114
34	Huntingtons disease_Homo sapiens_hsa05016	1.30483722
35	Rheumatoid arthritis_Homo sapiens_hsa05323	1.27374692
36	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.23804528
37	RNA polymerase_Homo sapiens_hsa03020	1.21370581
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.18315825
39	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.13607683
40	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.12962229
41	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.12382736
42	Antigen processing and presentation_Homo sapiens_hsa04612	1.09359448
43	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.08974169
44	Ether lipid metabolism_Homo sapiens_hsa00565	1.04605446
45	Morphine addiction_Homo sapiens_hsa05032	1.04200892
46	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.02627130
47	Leishmaniasis_Homo sapiens_hsa05140	0.99338959
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98235914
49	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.98205156
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.93372824
51	Butanoate metabolism_Homo sapiens_hsa00650	0.92101569
52	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.91873499
53	One carbon pool by folate_Homo sapiens_hsa00670	0.89294984
54	Olfactory transduction_Homo sapiens_hsa04740	0.89154384
55	ABC transporters_Homo sapiens_hsa02010	0.84364765
56	Taste transduction_Homo sapiens_hsa04742	0.81383610
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80575603
58	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.79516050
59	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.78736281
60	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.77052805
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.75092902
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74454211
63	Retinol metabolism_Homo sapiens_hsa00830	0.70744034
64	Propanoate metabolism_Homo sapiens_hsa00640	0.67062966
65	Serotonergic synapse_Homo sapiens_hsa04726	0.66860887
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62933228
67	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.60475599
68	GABAergic synapse_Homo sapiens_hsa04727	0.59325330
69	Malaria_Homo sapiens_hsa05144	0.58249038
70	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.57900678
71	Peroxisome_Homo sapiens_hsa04146	0.53532512
72	Circadian entrainment_Homo sapiens_hsa04713	0.52027014
73	Tuberculosis_Homo sapiens_hsa05152	0.49949841
74	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.49792006
75	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.48443019
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.47988404
77	Purine metabolism_Homo sapiens_hsa00230	0.47866675
78	Mismatch repair_Homo sapiens_hsa03430	0.47603548
79	Glutamatergic synapse_Homo sapiens_hsa04724	0.46981244
80	Nucleotide excision repair_Homo sapiens_hsa03420	0.46070719
81	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.45658665
82	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.45252161
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.44869104
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42416522
85	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.40296181
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40256052
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40240572
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38393802
89	Measles_Homo sapiens_hsa05162	0.38170406
90	Salivary secretion_Homo sapiens_hsa04970	0.37830804
91	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.36664685
92	Viral myocarditis_Homo sapiens_hsa05416	0.35845552
93	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.34471233
94	Spliceosome_Homo sapiens_hsa03040	0.33851875
95	Toxoplasmosis_Homo sapiens_hsa05145	0.33310842
96	Metabolic pathways_Homo sapiens_hsa01100	0.32906647
97	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.31017024
98	Pyrimidine metabolism_Homo sapiens_hsa00240	0.25323002
99	Selenocompound metabolism_Homo sapiens_hsa00450	0.25206202
100	Herpes simplex infection_Homo sapiens_hsa05168	0.25137534

RPL21P123

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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