ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.34076961
2	ATP synthesis coupled proton transport (GO:0015986)	5.34076961
3	protein neddylation (GO:0045116)	5.17274167
4	DNA deamination (GO:0045006)	4.96154320
5	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.93196496
6	regulation of isotype switching to IgG isotypes (GO:0048302)	4.85414869
7	positive regulation of interleukin-17 production (GO:0032740)	4.84074863
8	cellular response to exogenous dsRNA (GO:0071360)	4.54721950
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.52998194
10	behavioral response to nicotine (GO:0035095)	4.49633069
11	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.25910750
12	chaperone-mediated protein transport (GO:0072321)	4.24405733
13	ribosomal large subunit biogenesis (GO:0042273)	4.23284070
14	regulation of immunoglobulin secretion (GO:0051023)	4.21271255
15	water-soluble vitamin biosynthetic process (GO:0042364)	3.92090705
16	viral transcription (GO:0019083)	3.90557136
17	translational termination (GO:0006415)	3.74999419
18	protein complex biogenesis (GO:0070271)	3.66805898
19	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.59487400
20	NADH dehydrogenase complex assembly (GO:0010257)	3.59487400
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.59487400
22	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.59314336
23	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.54414333
24	cotranslational protein targeting to membrane (GO:0006613)	3.53288915
25	protein targeting to ER (GO:0045047)	3.51295292
26	positive regulation of isotype switching (GO:0045830)	3.50575831
27	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.50422653
28	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.50422653
29	positive regulation of defense response to virus by host (GO:0002230)	3.49824930
30	mitochondrial respiratory chain complex assembly (GO:0033108)	3.37770215
31	kynurenine metabolic process (GO:0070189)	3.36850608
32	protein localization to endoplasmic reticulum (GO:0070972)	3.35757755
33	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.33392004
34	maturation of SSU-rRNA (GO:0030490)	3.30260402
35	positive regulation of natural killer cell differentiation (GO:0032825)	3.28994618
36	translational elongation (GO:0006414)	3.28588645
37	rRNA modification (GO:0000154)	3.27961240
38	positive regulation of DNA recombination (GO:0045911)	3.25403343
39	regulation of regulatory T cell differentiation (GO:0045589)	3.22412504
40	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.20779421
41	regulation of chronic inflammatory response (GO:0002676)	3.19717393
42	regulation of interleukin-17 production (GO:0032660)	3.16121018
43	GTP biosynthetic process (GO:0006183)	3.14467913
44	interferon-gamma production (GO:0032609)	3.14218028
45	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.14058201
46	termination of RNA polymerase III transcription (GO:0006386)	3.14058201
47	indole-containing compound catabolic process (GO:0042436)	3.13842359
48	indolalkylamine catabolic process (GO:0046218)	3.13842359
49	tryptophan catabolic process (GO:0006569)	3.13842359
50	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.13110579
51	cellular response to interferon-beta (GO:0035458)	3.10486003
52	ribosomal small subunit assembly (GO:0000028)	3.10428822
53	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.09375227
54	proteasome assembly (GO:0043248)	3.07928374
55	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.07132515
56	rRNA methylation (GO:0031167)	3.06922268
57	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.05755316
58	ATP biosynthetic process (GO:0006754)	3.03003969
59	electron transport chain (GO:0022900)	3.02778659
60	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.01043809
61	respiratory electron transport chain (GO:0022904)	2.99808957
62	viral life cycle (GO:0019058)	2.99325549
63	DNA double-strand break processing (GO:0000729)	2.95369296
64	positive regulation of B cell mediated immunity (GO:0002714)	2.95249167
65	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.95249167
66	translation (GO:0006412)	2.93620495
67	cytidine deamination (GO:0009972)	2.93429915
68	cytidine metabolic process (GO:0046087)	2.93429915
69	cytidine catabolic process (GO:0006216)	2.93429915
70	termination of RNA polymerase I transcription (GO:0006363)	2.88938986
71	positive regulation of interferon-gamma biosynthetic process (GO:0045078)	2.88859996
72	piRNA metabolic process (GO:0034587)	2.87087742
73	pseudouridine synthesis (GO:0001522)	2.84694948
74	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.84221769
75	cellular component biogenesis (GO:0044085)	2.80769974
76	hydrogen ion transmembrane transport (GO:1902600)	2.80468670
77	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.75801982
78	positive regulation of activated T cell proliferation (GO:0042104)	2.75206398
79	sperm motility (GO:0030317)	2.74514190
80	proton transport (GO:0015992)	2.73315253
81	positive regulation of chemokine biosynthetic process (GO:0045080)	2.70963873
82	ribosomal small subunit biogenesis (GO:0042274)	2.68543608
83	negative regulation of T cell differentiation in thymus (GO:0033085)	2.67463946
84	parturition (GO:0007567)	2.67451491
85	positive regulation of interleukin-12 production (GO:0032735)	2.66854365
86	cellular protein complex disassembly (GO:0043624)	2.66645732
87	hydrogen transport (GO:0006818)	2.66441685
88	positive regulation of T cell migration (GO:2000406)	2.66343702
89	translational initiation (GO:0006413)	2.65330129
90	rRNA metabolic process (GO:0016072)	2.64992828
91	positive regulation of fatty acid transport (GO:2000193)	2.63188689
92	rRNA processing (GO:0006364)	2.63173458
93	positive regulation of prostaglandin secretion (GO:0032308)	2.62124467
94	ribonucleoprotein complex biogenesis (GO:0022613)	2.62081830
95	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.59991813
96	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.57644039
97	cellular response to dsRNA (GO:0071359)	2.57559986
98	regulation of podosome assembly (GO:0071801)	2.56727338
99	DNA methylation involved in gamete generation (GO:0043046)	2.54379760
100	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	2.54325564

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.68050179
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.21493149
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.50873740
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.49593104
5	VDR_22108803_ChIP-Seq_LS180_Human	2.83649317
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.66716315
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.63601239
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.53195500
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.46987956
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.30250101
11	EWS_26573619_Chip-Seq_HEK293_Human	2.26347191
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.23530340
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.17569394
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.14729299
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.14175250
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.01897987
17	IGF1R_20145208_ChIP-Seq_DFB_Human	1.91028532
18	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.90659956
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.89780693
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.87335959
21	TP53_22573176_ChIP-Seq_HFKS_Human	1.86516370
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.85753230
23	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.82773644
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.78273544
25	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.78094687
26	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.70796243
27	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.66297298
28	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.63147356
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.56082028
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.54290823
31	FUS_26573619_Chip-Seq_HEK293_Human	1.51311195
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.48777689
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47059728
34	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.45690764
35	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.44252160
36	NANOG_19829295_ChIP-Seq_ESCs_Human	1.44235219
37	SOX2_19829295_ChIP-Seq_ESCs_Human	1.44235219
38	P300_19829295_ChIP-Seq_ESCs_Human	1.41832678
39	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.41631882
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.38051073
41	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.38051073
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.37351770
43	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35993986
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.35606637
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.30360790
46	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.30032767
47	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.29757731
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.26258803
49	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.26194890
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.25859100
51	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.25820202
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.22651294
53	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.22238007
54	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21298525
55	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21024541
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20464800
57	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.19204180
58	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.18445138
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.17267825
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.17267825
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14212775
62	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.14149179
63	ERG_20517297_ChIP-Seq_VCAP_Human	1.14025611
64	GATA3_26560356_Chip-Seq_TH2_Human	1.13939710
65	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.13777249
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13326041
67	TTF2_22483619_ChIP-Seq_HELA_Human	1.12348169
68	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.11475934
69	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11112971
70	GBX2_23144817_ChIP-Seq_PC3_Human	1.10745468
71	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.10212036
72	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.09489562
73	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.09104597
74	NANOG_20526341_ChIP-Seq_ESCs_Human	1.08494226
75	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.06050434
76	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06038169
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05824718
78	MYC_19829295_ChIP-Seq_ESCs_Human	1.05754075
79	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.04675836
80	TCF4_22108803_ChIP-Seq_LS180_Human	1.03143363
81	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03020450
82	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.02946765
83	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00678779
84	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.00678779
85	AR_20517297_ChIP-Seq_VCAP_Human	0.99462541
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99231195
87	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.97975589
88	NCOR_22424771_ChIP-Seq_293T_Human	0.97607533
89	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.96726460
90	STAT1_20625510_ChIP-Seq_HELA_Human	0.96718861
91	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.91129627
92	TAF2_19829295_ChIP-Seq_ESCs_Human	0.91015231
93	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.90646306
94	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.90087001
95	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.89432039
96	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.87909484
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.87466433
98	GABP_19822575_ChIP-Seq_HepG2_Human	0.86659467
99	OCT4_20526341_ChIP-Seq_ESCs_Human	0.86312456
100	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.84919772

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	3.95334295
2	MP0008877_abnormal_DNA_methylation	3.79450591
3	MP0005671_abnormal_response_to	3.25201284
4	MP0001873_stomach_inflammation	2.66268577
5	MP0000685_abnormal_immune_system	2.44367666
6	MP0004142_abnormal_muscle_tone	2.26055773
7	MP0006072_abnormal_retinal_apoptosis	2.22795901
8	MP0002876_abnormal_thyroid_physiology	2.20017959
9	MP0006292_abnormal_olfactory_placode	2.17260116
10	MP0003787_abnormal_imprinting	1.93865645
11	MP0008875_abnormal_xenobiotic_pharmacok	1.90703179
12	MP0001968_abnormal_touch/_nociception	1.87141348
13	MP0004147_increased_porphyrin_level	1.86404401
14	MP0008872_abnormal_physiological_respon	1.86127118
15	MP0005645_abnormal_hypothalamus_physiol	1.85906034
16	MP0002254_reproductive_system_inflammat	1.77694019
17	MP0005000_abnormal_immune_tolerance	1.72148287
18	MP0001529_abnormal_vocalization	1.71934746
19	MP0008057_abnormal_DNA_replication	1.71341467
20	MP0001919_abnormal_reproductive_system	1.68881330
21	MP0002736_abnormal_nociception_after	1.66001481
22	MP0009764_decreased_sensitivity_to	1.63963385
23	MP0001348_abnormal_lacrimal_gland	1.63490477
24	MP0002148_abnormal_hypersensitivity_rea	1.61688191
25	MP0008995_early_reproductive_senescence	1.60045146
26	MP0004742_abnormal_vestibular_system	1.55553035
27	MP0001790_abnormal_immune_system	1.55287097
28	MP0005387_immune_system_phenotype	1.55287097
29	MP0008058_abnormal_DNA_repair	1.54785349
30	MP0009785_altered_susceptibility_to	1.54328286
31	MP0005551_abnormal_eye_electrophysiolog	1.53917798
32	MP0001800_abnormal_humoral_immune	1.53151602
33	MP0003786_premature_aging	1.49726542
34	MP0005410_abnormal_fertilization	1.49299580
35	MP0003646_muscle_fatigue	1.47910170
36	MP0005389_reproductive_system_phenotype	1.47791759
37	MP0009379_abnormal_foot_pigmentation	1.47051967
38	MP0001486_abnormal_startle_reflex	1.44065038
39	MP0005367_renal/urinary_system_phenotyp	1.38819615
40	MP0000516_abnormal_urinary_system	1.38819615
41	MP0006276_abnormal_autonomic_nervous	1.37023271
42	MP0001853_heart_inflammation	1.35731412
43	MP0001502_abnormal_circadian_rhythm	1.35706037
44	MP0002638_abnormal_pupillary_reflex	1.33065700
45	MP0002102_abnormal_ear_morphology	1.29895679
46	MP0001440_abnormal_grooming_behavior	1.27935505
47	MP0001905_abnormal_dopamine_level	1.27336599
48	MP0003011_delayed_dark_adaptation	1.27236800
49	MP0003436_decreased_susceptibility_to	1.25477424
50	MP0002272_abnormal_nervous_system	1.23994648
51	MP0000372_irregular_coat_pigmentation	1.23181833
52	MP0001501_abnormal_sleep_pattern	1.22850553
53	MP0002723_abnormal_immune_serum	1.20172076
54	MP0005646_abnormal_pituitary_gland	1.20111850
55	MP0002160_abnormal_reproductive_system	1.19550177
56	MP0002006_tumorigenesis	1.18281487
57	MP0004019_abnormal_vitamin_homeostasis	1.16582807
58	MP0005253_abnormal_eye_physiology	1.11618324
59	MP0002405_respiratory_system_inflammati	1.10921699
60	MP0002166_altered_tumor_susceptibility	1.10710138
61	MP0003806_abnormal_nucleotide_metabolis	1.09867890
62	MP0010386_abnormal_urinary_bladder	1.09440964
63	MP0006082_CNS_inflammation	1.09287676
64	MP0009046_muscle_twitch	1.05783418
65	MP0009745_abnormal_behavioral_response	1.04543827
66	MP0003186_abnormal_redox_activity	1.03996501
67	MP0002452_abnormal_antigen_presenting	1.02857783
68	MP0002138_abnormal_hepatobiliary_system	1.02296653
69	MP0001845_abnormal_inflammatory_respons	1.00833699
70	MP0010155_abnormal_intestine_physiology	1.00338063
71	MP0001986_abnormal_taste_sensitivity	1.00199184
72	MP0002163_abnormal_gland_morphology	0.97531343
73	MP0003195_calcinosis	0.95838562
74	MP0003880_abnormal_central_pattern	0.94586203
75	MP0001485_abnormal_pinna_reflex	0.94477563
76	MP0002420_abnormal_adaptive_immunity	0.93086532
77	MP0005025_abnormal_response_to	0.92897256
78	MP0002837_dystrophic_cardiac_calcinosis	0.92287375
79	MP0002277_abnormal_respiratory_mucosa	0.88379628
80	MP0000604_amyloidosis	0.87904273
81	MP0001819_abnormal_immune_cell	0.86574025
82	MP0000465_gastrointestinal_hemorrhage	0.84487271
83	MP0002210_abnormal_sex_determination	0.84004822
84	MP0009333_abnormal_splenocyte_physiolog	0.83623858
85	MP0001984_abnormal_olfaction	0.83484634
86	MP0003724_increased_susceptibility_to	0.82920022
87	MP0002572_abnormal_emotion/affect_behav	0.82194618
88	MP0001119_abnormal_female_reproductive	0.81040600
89	MP0005084_abnormal_gallbladder_morpholo	0.79627562
90	MP0003763_abnormal_thymus_physiology	0.79371180
91	MP0005379_endocrine/exocrine_gland_phen	0.78969599
92	MP0000427_abnormal_hair_cycle	0.77649355
93	MP0005195_abnormal_posterior_eye	0.77156436
94	MP0000653_abnormal_sex_gland	0.77002179
95	MP0002938_white_spotting	0.76345495
96	MP0003122_maternal_imprinting	0.75755556
97	MP0001293_anophthalmia	0.75719839
98	MP0001929_abnormal_gametogenesis	0.74696534
99	MP0005310_abnormal_salivary_gland	0.74439787
100	MP0003718_maternal_effect	0.74117840

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	4.96832402
2	3-Methylglutaconic aciduria (HP:0003535)	4.91909051
3	Acute necrotizing encephalopathy (HP:0006965)	4.28061979
4	Acute encephalopathy (HP:0006846)	4.02055595
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.67887223
6	Progressive macrocephaly (HP:0004481)	3.66896243
7	Mitochondrial inheritance (HP:0001427)	3.65667261
8	Increased CSF lactate (HP:0002490)	3.33091565
9	Congenital stationary night blindness (HP:0007642)	3.22438395
10	Congenital, generalized hypertrichosis (HP:0004540)	3.20451229
11	Abnormal rod and cone electroretinograms (HP:0008323)	3.18266452
12	Optic disc pallor (HP:0000543)	3.02021483
13	Molar tooth sign on MRI (HP:0002419)	2.95004482
14	Abnormality of midbrain morphology (HP:0002418)	2.95004482
15	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.94939461
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.90375499
17	Lipid accumulation in hepatocytes (HP:0006561)	2.89631808
18	Testicular atrophy (HP:0000029)	2.88897256
19	Increased IgM level (HP:0003496)	2.87737160
20	IgG deficiency (HP:0004315)	2.86003970
21	Hepatocellular necrosis (HP:0001404)	2.83421831
22	Abnormality of cells of the erythroid lineage (HP:0012130)	2.82522543
23	Nephronophthisis (HP:0000090)	2.80468811
24	Asplenia (HP:0001746)	2.73096956
25	Increased hepatocellular lipid droplets (HP:0006565)	2.71214343
26	Pendular nystagmus (HP:0012043)	2.70203648
27	Pancreatic cysts (HP:0001737)	2.69754390
28	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.62434470
29	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.62434470
30	Decreased central vision (HP:0007663)	2.57410226
31	Type II lissencephaly (HP:0007260)	2.57028405
32	Cerebral edema (HP:0002181)	2.53197608
33	Methylmalonic acidemia (HP:0002912)	2.52574317
34	Increased serum lactate (HP:0002151)	2.50759667
35	Reticulocytopenia (HP:0001896)	2.49564915
36	Attenuation of retinal blood vessels (HP:0007843)	2.46432785
37	Dyschromatopsia (HP:0007641)	2.45062513
38	Macrocytic anemia (HP:0001972)	2.38276540
39	Septo-optic dysplasia (HP:0100842)	2.34523779
40	Visual hallucinations (HP:0002367)	2.32721648
41	Pancreatic fibrosis (HP:0100732)	2.30044223
42	Azoospermia (HP:0000027)	2.27433582
43	Hepatic necrosis (HP:0002605)	2.25412588
44	Increased corneal curvature (HP:0100692)	2.25121223
45	Keratoconus (HP:0000563)	2.25121223
46	Confusion (HP:0001289)	2.24823455
47	Abnormality of the renal medulla (HP:0100957)	2.23931726
48	Exertional dyspnea (HP:0002875)	2.23453002
49	Inability to walk (HP:0002540)	2.22600207
50	Absent thumb (HP:0009777)	2.18546054
51	Renal Fanconi syndrome (HP:0001994)	2.18256161
52	Autoimmune thrombocytopenia (HP:0001973)	2.17546925
53	Abnormality of renal resorption (HP:0011038)	2.16730772
54	Abolished electroretinogram (ERG) (HP:0000550)	2.16469951
55	Chronic hepatic failure (HP:0100626)	2.13407283
56	True hermaphroditism (HP:0010459)	2.11905309
57	Anterior segment dysgenesis (HP:0007700)	2.11260261
58	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.11062205
59	Abnormality of incisor morphology (HP:0011063)	2.09597030
60	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.07466648
61	Methylmalonic aciduria (HP:0012120)	2.06191239
62	Abnormality of T cell physiology (HP:0011840)	2.03722956
63	Abnormal respiratory epithelium morphology (HP:0012253)	2.02108040
64	Abnormal respiratory motile cilium morphology (HP:0005938)	2.02108040
65	Stenosis of the external auditory canal (HP:0000402)	2.01949043
66	Bile duct proliferation (HP:0001408)	2.00956504
67	Abnormal biliary tract physiology (HP:0012439)	2.00956504
68	Respiratory failure (HP:0002878)	1.99377772
69	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.98075743
70	Lethargy (HP:0001254)	1.97108638
71	Optic nerve hypoplasia (HP:0000609)	1.94101985
72	Abnormality of the renal cortex (HP:0011035)	1.93269623
73	Cerebellar dysplasia (HP:0007033)	1.91816750
74	Lactic acidosis (HP:0003128)	1.89875364
75	Rib fusion (HP:0000902)	1.88822020
76	Hypoproteinemia (HP:0003075)	1.88645992
77	Male pseudohermaphroditism (HP:0000037)	1.87142033
78	Genetic anticipation (HP:0003743)	1.86746271
79	Cleft eyelid (HP:0000625)	1.86131447
80	Agitation (HP:0000713)	1.85657517
81	Abnormal number of erythroid precursors (HP:0012131)	1.84555151
82	Type I transferrin isoform profile (HP:0003642)	1.84351513
83	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.83866307
84	Arthropathy (HP:0003040)	1.83306647
85	Central scotoma (HP:0000603)	1.82572801
86	Leukodystrophy (HP:0002415)	1.81840827
87	Renal cortical cysts (HP:0000803)	1.81446648
88	Abnormal spermatogenesis (HP:0008669)	1.79540759
89	Hypoplasia of the radius (HP:0002984)	1.79217321
90	Abnormality of T cells (HP:0002843)	1.78500971
91	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.77732897
92	Elevated erythrocyte sedimentation rate (HP:0003565)	1.77678269
93	Sclerocornea (HP:0000647)	1.77126169
94	Abnormal ciliary motility (HP:0012262)	1.74181262
95	Hypoplasia of the ulna (HP:0003022)	1.72995841
96	Abnormality of vitamin B metabolism (HP:0004340)	1.72276508
97	Aplastic anemia (HP:0001915)	1.71212561
98	Forearm undergrowth (HP:0009821)	1.71001930
99	Abnormality of the labia minora (HP:0012880)	1.70838110
100	Exercise intolerance (HP:0003546)	1.70579073

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.89221836
2	EIF2AK3	3.53297464
3	FRK	3.12840599
4	ADRBK2	2.86407059
5	MST4	2.80780341
6	MAP4K2	2.73621727
7	NUAK1	2.65756485
8	EIF2AK1	2.63698656
9	MAP4K1	2.40457708
10	TAOK3	2.08066540
11	STK16	2.06376427
12	MAP3K12	2.03125214
13	PINK1	1.88588780
14	GRK1	1.77752780
15	WNK4	1.76497756
16	VRK2	1.64438066
17	CAMKK2	1.56267141
18	PAK3	1.56004419
19	AKT3	1.41832594
20	DYRK2	1.39032636
21	PLK4	1.35163832
22	ZAK	1.31054197
23	BMPR1B	1.30340227
24	PLK2	1.30130088
25	CASK	1.26853769
26	WNK3	1.21177656
27	IKBKB	1.20128576
28	BMPR2	1.18050714
29	PHKG2	1.14381288
30	PHKG1	1.14381288
31	DAPK2	1.14048796
32	VRK1	1.10965614
33	NME1	1.07810933
34	INSRR	1.04267474
35	MATK	0.99598796
36	TLK1	0.98679111
37	MYLK	0.96954537
38	IKBKE	0.94628550
39	TIE1	0.93457210
40	NEK1	0.93058279
41	TEC	0.92449042
42	TRIM28	0.91304206
43	TSSK6	0.87269481
44	PIK3CA	0.81803047
45	EIF2AK2	0.81333768
46	MAP3K11	0.80347140
47	KIT	0.75937736
48	SYK	0.75572551
49	BRSK2	0.75019706
50	PRKCE	0.74519161
51	GRK6	0.73518735
52	LYN	0.73152351
53	DAPK3	0.71689472
54	CDK8	0.67976317
55	CSNK1G2	0.67364289
56	CDK19	0.66598955
57	CSNK1G3	0.63175505
58	CSNK1G1	0.62869005
59	MKNK2	0.62719953
60	CSNK1A1L	0.61627889
61	EPHA3	0.61334042
62	OXSR1	0.59943181
63	PRKCQ	0.59176729
64	TNIK	0.58589778
65	BCKDK	0.58250819
66	SGK494	0.57557871
67	SGK223	0.57557871
68	RPS6KA6	0.56879539
69	PLK3	0.56872899
70	STK39	0.55338462
71	STK38L	0.54822377
72	ADRBK1	0.54819718
73	PRKACA	0.54212822
74	CSNK2A2	0.52512865
75	ITK	0.52379461
76	GRK7	0.51002135
77	CSNK1A1	0.50933767
78	PRKCG	0.49782459
79	IGF1R	0.49350226
80	OBSCN	0.47624251
81	CAMK2D	0.47384104
82	NME2	0.46039323
83	SGK1	0.45849856
84	PRKG1	0.45686337
85	EPHA4	0.45644849
86	BTK	0.45587487
87	SGK2	0.44975508
88	CAMK2G	0.42498400
89	FES	0.42290361
90	BUB1	0.39552225
91	CSNK2A1	0.38994986
92	RPS6KL1	0.38947978
93	RPS6KC1	0.38947978
94	PAK4	0.38831049
95	PRKCA	0.38586953
96	CAMK2A	0.38575403
97	PRKCZ	0.38161489
98	BRSK1	0.37687944
99	MARK3	0.37470640
100	PRKCD	0.37269270

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.81690475
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.49145775
3	Proteasome_Homo sapiens_hsa03050	3.47511684
4	Asthma_Homo sapiens_hsa05310	3.29928948
5	Allograft rejection_Homo sapiens_hsa05330	3.19263338
6	Parkinsons disease_Homo sapiens_hsa05012	2.92299960
7	Protein export_Homo sapiens_hsa03060	2.82643194
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.74941428
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.67515282
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.45588700
11	RNA polymerase_Homo sapiens_hsa03020	2.40723293
12	Basal transcription factors_Homo sapiens_hsa03022	2.37288013
13	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.21329819
14	Graft-versus-host disease_Homo sapiens_hsa05332	2.19808018
15	Alzheimers disease_Homo sapiens_hsa05010	2.01923264
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.95666458
17	Huntingtons disease_Homo sapiens_hsa05016	1.91251624
18	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.84294600
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.77005380
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.74470499
21	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.57169719
22	Rheumatoid arthritis_Homo sapiens_hsa05323	1.56963351
23	RNA degradation_Homo sapiens_hsa03018	1.54910541
24	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.44597194
25	Caffeine metabolism_Homo sapiens_hsa00232	1.43062284
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.42313442
27	Homologous recombination_Homo sapiens_hsa03440	1.39855396
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.29428434
29	Phototransduction_Homo sapiens_hsa04744	1.28048334
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.28000843
31	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.25748325
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.25196833
33	Primary immunodeficiency_Homo sapiens_hsa05340	1.19606930
34	One carbon pool by folate_Homo sapiens_hsa00670	1.09349452
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.08157493
36	Regulation of autophagy_Homo sapiens_hsa04140	1.06328493
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00329425
38	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98883397
39	Spliceosome_Homo sapiens_hsa03040	0.90405674
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86407835
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.85765902
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82569766
43	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.79139780
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78226293
45	Antigen processing and presentation_Homo sapiens_hsa04612	0.77601219
46	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.75086002
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.74207801
48	Folate biosynthesis_Homo sapiens_hsa00790	0.71734473
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.68128933
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.67970032
51	Olfactory transduction_Homo sapiens_hsa04740	0.67231353
52	Purine metabolism_Homo sapiens_hsa00230	0.67194619
53	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.66540414
54	Mismatch repair_Homo sapiens_hsa03430	0.65598459
55	Nicotine addiction_Homo sapiens_hsa05033	0.64706904
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64213587
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.63677071
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62277059
59	Retinol metabolism_Homo sapiens_hsa00830	0.60962591
60	RNA transport_Homo sapiens_hsa03013	0.60447213
61	Nitrogen metabolism_Homo sapiens_hsa00910	0.60367671
62	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.60347603
63	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.59233968
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.57267075
65	Taste transduction_Homo sapiens_hsa04742	0.56001009
66	African trypanosomiasis_Homo sapiens_hsa05143	0.55998172
67	Mineral absorption_Homo sapiens_hsa04978	0.54057725
68	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.51499563
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.50901451
70	Butanoate metabolism_Homo sapiens_hsa00650	0.50423367
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50189994
72	Propanoate metabolism_Homo sapiens_hsa00640	0.49256403
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48510594
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.48482521
75	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.47585609
76	Malaria_Homo sapiens_hsa05144	0.46180113
77	Measles_Homo sapiens_hsa05162	0.45766181
78	Metabolic pathways_Homo sapiens_hsa01100	0.41003882
79	Sulfur metabolism_Homo sapiens_hsa00920	0.40431067
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.39539073
81	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39091463
82	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38916838
83	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.38840414
84	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.38031359
85	Circadian rhythm_Homo sapiens_hsa04710	0.37963792
86	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.34354626
87	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.32156999
88	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.31911476
89	Viral myocarditis_Homo sapiens_hsa05416	0.30022724
90	Morphine addiction_Homo sapiens_hsa05032	0.27784863
91	Non-homologous end-joining_Homo sapiens_hsa03450	0.27550861
92	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.27147121
93	Serotonergic synapse_Homo sapiens_hsa04726	0.27095385
94	Glutathione metabolism_Homo sapiens_hsa00480	0.25309041
95	Peroxisome_Homo sapiens_hsa04146	0.24410963
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.24285268
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.24201017
98	DNA replication_Homo sapiens_hsa03030	0.23753858
99	Steroid biosynthesis_Homo sapiens_hsa00100	0.22068269
100	Salivary secretion_Homo sapiens_hsa04970	0.21258152

RPL21P126

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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