ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.86294430
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.77289895
3	ATP synthesis coupled proton transport (GO:0015986)	5.77289895
4	viral transcription (GO:0019083)	5.73266580
5	translational termination (GO:0006415)	5.57288491
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.17851328
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.12977804
8	cotranslational protein targeting to membrane (GO:0006613)	5.06399215
9	protein targeting to ER (GO:0045047)	5.02043206
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.83948877
11	protein localization to endoplasmic reticulum (GO:0070972)	4.78557205
12	translational elongation (GO:0006414)	4.72847837
13	protein neddylation (GO:0045116)	4.69703849
14	behavioral response to nicotine (GO:0035095)	4.61609410
15	ribosomal large subunit biogenesis (GO:0042273)	4.52087242
16	ribosomal small subunit biogenesis (GO:0042274)	4.39374363
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.36020319
18	protein complex biogenesis (GO:0070271)	4.35885056
19	water-soluble vitamin biosynthetic process (GO:0042364)	4.33197788
20	NADH dehydrogenase complex assembly (GO:0010257)	4.29185322
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.29185322
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.29185322
23	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.28847590
24	viral life cycle (GO:0019058)	4.12312354
25	cellular protein complex disassembly (GO:0043624)	4.10500732
26	chaperone-mediated protein transport (GO:0072321)	4.07224361
27	mitochondrial respiratory chain complex assembly (GO:0033108)	4.04847753
28	respiratory electron transport chain (GO:0022904)	3.97951610
29	electron transport chain (GO:0022900)	3.97362610
30	translational initiation (GO:0006413)	3.93187697
31	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.89396542
32	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.87653722
33	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.87199351
34	maturation of SSU-rRNA (GO:0030490)	3.76668857
35	DNA deamination (GO:0045006)	3.74413295
36	translation (GO:0006412)	3.65919410
37	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.65905515
38	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.40686306
39	termination of RNA polymerase III transcription (GO:0006386)	3.40686306
40	protein complex disassembly (GO:0043241)	3.37588725
41	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.33494751
42	hydrogen ion transmembrane transport (GO:1902600)	3.30828196
43	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.28899794
44	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.28899794
45	GTP biosynthetic process (GO:0006183)	3.28594059
46	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.25867503
47	cellular component biogenesis (GO:0044085)	3.25710928
48	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.25271701
49	macromolecular complex disassembly (GO:0032984)	3.25101112
50	ATP biosynthetic process (GO:0006754)	3.25006485
51	peptidyl-histidine modification (GO:0018202)	3.24181298
52	protein targeting to membrane (GO:0006612)	3.23578963
53	regulation of cellular respiration (GO:0043457)	3.14352777
54	protein-cofactor linkage (GO:0018065)	3.12687238
55	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.07982277
56	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.06378743
57	regulation of immunoglobulin secretion (GO:0051023)	3.06317965
58	proton transport (GO:0015992)	3.06023000
59	proteasome assembly (GO:0043248)	3.05916450
60	respiratory chain complex IV assembly (GO:0008535)	3.04431623
61	hydrogen transport (GO:0006818)	3.02304355
62	ribonucleoprotein complex biogenesis (GO:0022613)	2.99856252
63	fucose catabolic process (GO:0019317)	2.97368650
64	L-fucose metabolic process (GO:0042354)	2.97368650
65	L-fucose catabolic process (GO:0042355)	2.97368650
66	intracellular protein transmembrane import (GO:0044743)	2.96005093
67	mRNA catabolic process (GO:0006402)	2.90858474
68	negative regulation of T cell differentiation in thymus (GO:0033085)	2.89459391
69	cytochrome complex assembly (GO:0017004)	2.80640805
70	inner mitochondrial membrane organization (GO:0007007)	2.79107994
71	rRNA processing (GO:0006364)	2.77310045
72	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.76654303
73	pseudouridine synthesis (GO:0001522)	2.75789105
74	rRNA metabolic process (GO:0016072)	2.73159398
75	nonmotile primary cilium assembly (GO:0035058)	2.71734809
76	parturition (GO:0007567)	2.71408783
77	rRNA modification (GO:0000154)	2.70545001
78	prenylation (GO:0097354)	2.70487544
79	protein prenylation (GO:0018342)	2.70487544
80	indolalkylamine metabolic process (GO:0006586)	2.68739412
81	somite development (GO:0061053)	2.67270865
82	epithelial cilium movement (GO:0003351)	2.66127917
83	spliceosomal complex assembly (GO:0000245)	2.65615587
84	RNA catabolic process (GO:0006401)	2.64780756
85	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.63188486
86	UTP biosynthetic process (GO:0006228)	2.62663435
87	tRNA processing (GO:0008033)	2.61919153
88	kynurenine metabolic process (GO:0070189)	2.61730708
89	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.57995711
90	mannosylation (GO:0097502)	2.57337944
91	aldehyde catabolic process (GO:0046185)	2.54549515
92	tryptophan catabolic process (GO:0006569)	2.53391149
93	indole-containing compound catabolic process (GO:0042436)	2.53391149
94	indolalkylamine catabolic process (GO:0046218)	2.53391149
95	nucleoside triphosphate biosynthetic process (GO:0009142)	2.49045860
96	tryptophan metabolic process (GO:0006568)	2.48296281
97	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.47710617
98	positive regulation of respiratory burst (GO:0060267)	2.47461296
99	dopamine transport (GO:0015872)	2.47441357
100	negative regulation of heart rate (GO:0010459)	2.46992546

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.98890787
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.58761051
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.39894342
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.37027678
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.19588454
6	VDR_22108803_ChIP-Seq_LS180_Human	3.13066838
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.11264850
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.87695662
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.57179619
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.46225272
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.46073931
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.41202569
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.20001820
14	EWS_26573619_Chip-Seq_HEK293_Human	1.97119097
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.95541289
16	ELK1_19687146_ChIP-ChIP_HELA_Human	1.95398568
17	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.94421273
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.85919835
19	FOXP3_21729870_ChIP-Seq_TREG_Human	1.81108822
20	TP53_22573176_ChIP-Seq_HFKS_Human	1.74089100
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.73281098
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.69333386
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.65102211
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.60169054
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.58609538
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.56721024
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.56311477
28	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.52451433
29	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.51745178
30	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.51312059
31	P300_19829295_ChIP-Seq_ESCs_Human	1.50927848
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.50807214
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.47920251
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.46880862
35	GBX2_23144817_ChIP-Seq_PC3_Human	1.45904910
36	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.45471903
37	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.44493364
38	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.44408330
39	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.43894333
40	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.43301809
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42836391
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42836391
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42742537
44	FUS_26573619_Chip-Seq_HEK293_Human	1.41544292
45	TTF2_22483619_ChIP-Seq_HELA_Human	1.41477183
46	TAF15_26573619_Chip-Seq_HEK293_Human	1.38704508
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.37812061
48	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.28035356
49	BCAT_22108803_ChIP-Seq_LS180_Human	1.25421334
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.25403797
51	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.24334825
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.23165019
53	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.22663178
54	NCOR_22424771_ChIP-Seq_293T_Human	1.20635719
55	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18943438
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.13973304
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.13973304
58	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.13720049
59	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13623110
60	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.13623110
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13058593
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13058593
63	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12936805
64	REST_21632747_ChIP-Seq_MESCs_Mouse	1.12683453
65	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.12372864
66	GABP_19822575_ChIP-Seq_HepG2_Human	1.11905052
67	AR_20517297_ChIP-Seq_VCAP_Human	1.11583918
68	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.09148668
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.08943483
70	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.07218966
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07045047
72	TAF2_19829295_ChIP-Seq_ESCs_Human	1.06694401
73	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.05346870
74	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.05242698
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04611227
76	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.04375233
77	ERA_21632823_ChIP-Seq_H3396_Human	1.04188928
78	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.03662200
79	MYC_19829295_ChIP-Seq_ESCs_Human	1.03256234
80	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02498959
81	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.01928893
82	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.01785683
83	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00751201
84	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.00703962
85	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.00158736
86	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99708421
87	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.99368540
88	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.97800949
89	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.95847749
90	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.95666014
91	RNF2_27304074_Chip-Seq_NSC_Mouse	0.92861834
92	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.91993682
93	ERG_20517297_ChIP-Seq_VCAP_Human	0.91742716
94	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.89653818
95	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.89363404
96	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.89058258
97	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.88771640
98	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.88623255
99	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.87527604
100	P53_21459846_ChIP-Seq_SAOS-2_Human	0.87097799

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.85038455
2	MP0003787_abnormal_imprinting	3.58162961
3	MP0006292_abnormal_olfactory_placode	3.09922937
4	MP0008877_abnormal_DNA_methylation	3.07696125
5	MP0001986_abnormal_taste_sensitivity	2.91563883
6	MP0004142_abnormal_muscle_tone	2.56632192
7	MP0008875_abnormal_xenobiotic_pharmacok	2.52338478
8	MP0003806_abnormal_nucleotide_metabolis	2.48423774
9	MP0003122_maternal_imprinting	2.35549724
10	MP0003195_calcinosis	2.32496338
11	MP0001984_abnormal_olfaction	2.11358443
12	MP0001835_abnormal_antigen_presentation	2.08653832
13	MP0003121_genomic_imprinting	2.06804805
14	MP0001968_abnormal_touch/_nociception	1.99346122
15	MP0005646_abnormal_pituitary_gland	1.99100800
16	MP0002163_abnormal_gland_morphology	1.95468212
17	MP0008872_abnormal_physiological_respon	1.92434704
18	MP0002837_dystrophic_cardiac_calcinosis	1.86837802
19	MP0005551_abnormal_eye_electrophysiolog	1.80879504
20	MP0002876_abnormal_thyroid_physiology	1.77505724
21	MP0006072_abnormal_retinal_apoptosis	1.75354373
22	MP0002653_abnormal_ependyma_morphology	1.65989169
23	MP0005645_abnormal_hypothalamus_physiol	1.61805953
24	MP0005379_endocrine/exocrine_gland_phen	1.60576978
25	MP0002938_white_spotting	1.60414579
26	MP0005084_abnormal_gallbladder_morpholo	1.58008489
27	MP0008789_abnormal_olfactory_epithelium	1.57803615
28	MP0002272_abnormal_nervous_system	1.57138918
29	MP0002102_abnormal_ear_morphology	1.55020566
30	MP0001529_abnormal_vocalization	1.53703411
31	MP0001293_anophthalmia	1.53549444
32	MP0001905_abnormal_dopamine_level	1.53531119
33	MP0002736_abnormal_nociception_after	1.51288643
34	MP0003011_delayed_dark_adaptation	1.50737124
35	MP0005389_reproductive_system_phenotype	1.50634943
36	MP0001485_abnormal_pinna_reflex	1.49578512
37	MP0004145_abnormal_muscle_electrophysio	1.48419618
38	MP0003123_paternal_imprinting	1.45835339
39	MP0002160_abnormal_reproductive_system	1.44830269
40	MP0009745_abnormal_behavioral_response	1.42284039
41	MP0001919_abnormal_reproductive_system	1.38006165
42	MP0004885_abnormal_endolymph	1.31994529
43	MP0003786_premature_aging	1.30528722
44	MP0002138_abnormal_hepatobiliary_system	1.28609169
45	MP0008058_abnormal_DNA_repair	1.25551454
46	MP0002234_abnormal_pharynx_morphology	1.23191915
47	MP0003718_maternal_effect	1.22793785
48	MP0003186_abnormal_redox_activity	1.20488183
49	MP0004147_increased_porphyrin_level	1.20213597
50	MP0005377_hearing/vestibular/ear_phenot	1.16626356
51	MP0003878_abnormal_ear_physiology	1.16626356
52	MP0002557_abnormal_social/conspecific_i	1.16146679
53	MP0004133_heterotaxia	1.14560377
54	MP0005253_abnormal_eye_physiology	1.12398900
55	MP0005394_taste/olfaction_phenotype	1.10826612
56	MP0005499_abnormal_olfactory_system	1.10826612
57	MP0001970_abnormal_pain_threshold	1.10699141
58	MP0001440_abnormal_grooming_behavior	1.10003848
59	MP0006276_abnormal_autonomic_nervous	1.09971713
60	MP0000631_abnormal_neuroendocrine_gland	1.08961116
61	MP0000427_abnormal_hair_cycle	1.07223108
62	MP0005671_abnormal_response_to	1.06502593
63	MP0004742_abnormal_vestibular_system	1.05914617
64	MP0001486_abnormal_startle_reflex	1.05897601
65	MP0001348_abnormal_lacrimal_gland	1.03469722
66	MP0002733_abnormal_thermal_nociception	1.02810999
67	MP0002254_reproductive_system_inflammat	1.01823132
68	MP0006036_abnormal_mitochondrial_physio	1.00536183
69	MP0002572_abnormal_emotion/affect_behav	0.98679528
70	MP0002638_abnormal_pupillary_reflex	0.96653223
71	MP0005195_abnormal_posterior_eye	0.94731743
72	MP0005075_abnormal_melanosome_morpholog	0.94637663
73	MP0002067_abnormal_sensory_capabilities	0.91169774
74	MP0009046_muscle_twitch	0.91133888
75	MP0002277_abnormal_respiratory_mucosa	0.90176162
76	MP0001501_abnormal_sleep_pattern	0.87529310
77	MP0000372_irregular_coat_pigmentation	0.83464454
78	MP0003283_abnormal_digestive_organ	0.83198240
79	MP0000613_abnormal_salivary_gland	0.83128940
80	MP0005423_abnormal_somatic_nervous	0.82972256
81	MP0002752_abnormal_somatic_nervous	0.82694189
82	MP0002184_abnormal_innervation	0.81703953
83	MP0002210_abnormal_sex_determination	0.81537743
84	MP0005636_abnormal_mineral_homeostasis	0.81440620
85	MP0002734_abnormal_mechanical_nocicepti	0.79967024
86	MP0001963_abnormal_hearing_physiology	0.79059304
87	MP0002693_abnormal_pancreas_physiology	0.78359609
88	MP0000049_abnormal_middle_ear	0.78061068
89	MP0000955_abnormal_spinal_cord	0.76431707
90	MP0005332_abnormal_amino_acid	0.74825173
91	MP0008995_early_reproductive_senescence	0.74555845
92	MP0010386_abnormal_urinary_bladder	0.74342535
93	MP0005408_hypopigmentation	0.71588069
94	MP0003119_abnormal_digestive_system	0.70142806
95	MP0000230_abnormal_systemic_arterial	0.70132538
96	MP0002229_neurodegeneration	0.69891158
97	MP0003936_abnormal_reproductive_system	0.68669925
98	MP0002064_seizures	0.68530579
99	MP0000026_abnormal_inner_ear	0.68170060
100	MP0002063_abnormal_learning/memory/cond	0.67865778

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.64821828
2	3-Methylglutaconic aciduria (HP:0003535)	3.98551192
3	Progressive macrocephaly (HP:0004481)	3.93747021
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.91969857
5	Mitochondrial inheritance (HP:0001427)	3.88854274
6	Reticulocytopenia (HP:0001896)	3.79969665
7	Acute encephalopathy (HP:0006846)	3.77392853
8	Pancreatic cysts (HP:0001737)	3.74728412
9	Abnormality of cells of the erythroid lineage (HP:0012130)	3.73970880
10	Increased CSF lactate (HP:0002490)	3.63433494
11	Pancreatic fibrosis (HP:0100732)	3.63002728
12	Molar tooth sign on MRI (HP:0002419)	3.62960142
13	Abnormality of midbrain morphology (HP:0002418)	3.62960142
14	Congenital, generalized hypertrichosis (HP:0004540)	3.38570613
15	Macrocytic anemia (HP:0001972)	3.30965221
16	Increased hepatocellular lipid droplets (HP:0006565)	3.27001662
17	Nephronophthisis (HP:0000090)	3.21514471
18	Abnormal number of erythroid precursors (HP:0012131)	3.20900678
19	Hepatocellular necrosis (HP:0001404)	3.19874664
20	Congenital stationary night blindness (HP:0007642)	3.05367515
21	Lipid accumulation in hepatocytes (HP:0006561)	3.02704328
22	Methylmalonic acidemia (HP:0002912)	2.97052996
23	Cerebral edema (HP:0002181)	2.85830056
24	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.84427552
25	Hepatic necrosis (HP:0002605)	2.78716574
26	Asplenia (HP:0001746)	2.78030593
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.76147266
28	True hermaphroditism (HP:0010459)	2.70887633
29	Abnormality of the renal medulla (HP:0100957)	2.70100948
30	Abolished electroretinogram (ERG) (HP:0000550)	2.68823379
31	Methylmalonic aciduria (HP:0012120)	2.67324597
32	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.67011829
33	Optic disc pallor (HP:0000543)	2.66788457
34	Abnormal biliary tract physiology (HP:0012439)	2.55291911
35	Bile duct proliferation (HP:0001408)	2.55291911
36	Renal Fanconi syndrome (HP:0001994)	2.48127290
37	Abnormality of the labia minora (HP:0012880)	2.47826159
38	Hypomagnesemia (HP:0002917)	2.43045976
39	Type II lissencephaly (HP:0007260)	2.36849963
40	Polydipsia (HP:0001959)	2.35482270
41	Abnormal drinking behavior (HP:0030082)	2.35482270
42	Medial flaring of the eyebrow (HP:0010747)	2.34286381
43	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.30610001
44	Cystic liver disease (HP:0006706)	2.30335013
45	Increased serum lactate (HP:0002151)	2.26879590
46	Sclerocornea (HP:0000647)	2.25039970
47	Exertional dyspnea (HP:0002875)	2.23889894
48	Pendular nystagmus (HP:0012043)	2.23460092
49	Pallor (HP:0000980)	2.23208989
50	Septo-optic dysplasia (HP:0100842)	2.21348943
51	Abnormality of the renal cortex (HP:0011035)	2.17998200
52	Tubular atrophy (HP:0000092)	2.15836360
53	Absent thumb (HP:0009777)	2.15608799
54	Abnormality of magnesium homeostasis (HP:0004921)	2.13466400
55	Stomatitis (HP:0010280)	2.13162366
56	Lactic acidosis (HP:0003128)	2.12267866
57	Abnormality of DNA repair (HP:0003254)	2.10156856
58	Increased intramyocellular lipid droplets (HP:0012240)	2.09183626
59	Leukodystrophy (HP:0002415)	2.08712929
60	Lethargy (HP:0001254)	2.06400457
61	Chronic hepatic failure (HP:0100626)	2.05105486
62	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.02468375
63	Polyuria (HP:0000103)	2.01640759
64	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.99412618
65	Absent/shortened dynein arms (HP:0200106)	1.99412618
66	Respiratory failure (HP:0002878)	1.97415470
67	IgG deficiency (HP:0004315)	1.94614862
68	Colon cancer (HP:0003003)	1.94443739
69	Hypothermia (HP:0002045)	1.94143799
70	Rib fusion (HP:0000902)	1.91498780
71	Testicular atrophy (HP:0000029)	1.90227225
72	Abnormality of vitamin B metabolism (HP:0004340)	1.88515977
73	Supernumerary spleens (HP:0009799)	1.88260631
74	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.87729006
75	Dicarboxylic aciduria (HP:0003215)	1.87729006
76	Growth hormone deficiency (HP:0000824)	1.87319668
77	Stenosis of the external auditory canal (HP:0000402)	1.85817386
78	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.81965003
79	Abnormality of renal resorption (HP:0011038)	1.79760658
80	Hyperphosphaturia (HP:0003109)	1.79732420
81	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.79719566
82	Type 2 muscle fiber atrophy (HP:0003554)	1.79072749
83	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.78214047
84	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.78214047
85	Optic nerve hypoplasia (HP:0000609)	1.77646013
86	Hyperglycinemia (HP:0002154)	1.77546823
87	Oligodactyly (hands) (HP:0001180)	1.76306666
88	Congenital hepatic fibrosis (HP:0002612)	1.74983066
89	Abnormal ciliary motility (HP:0012262)	1.72531415
90	Male pseudohermaphroditism (HP:0000037)	1.71413703
91	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.70847751
92	Exercise intolerance (HP:0003546)	1.70460040
93	Abnormality of urine glucose concentration (HP:0011016)	1.69543226
94	Glycosuria (HP:0003076)	1.69543226
95	Megaloblastic anemia (HP:0001889)	1.68751703
96	Increased muscle lipid content (HP:0009058)	1.66900327
97	Adrenal hypoplasia (HP:0000835)	1.66465785
98	Aplasia/hypoplasia of the uterus (HP:0008684)	1.66191377
99	Woolly hair (HP:0002224)	1.66135806
100	Anencephaly (HP:0002323)	1.65545642

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.84250034
2	MAP4K2	2.96665973
3	WNK4	2.92161877
4	FRK	2.76500386
5	ADRBK2	2.73037293
6	BMPR1B	2.66721912
7	NUAK1	2.62062821
8	GRK1	2.53616259
9	TLK1	2.37108146
10	DYRK2	2.30263754
11	ZAK	2.27273355
12	MST4	1.93404087
13	EIF2AK3	1.88288164
14	TXK	1.81956109
15	STK39	1.79238695
16	VRK2	1.79048100
17	CDK19	1.78795333
18	TIE1	1.72412282
19	PINK1	1.67236078
20	WNK3	1.64652103
21	OXSR1	1.63031213
22	TAOK3	1.50849596
23	NEK1	1.48833405
24	TNIK	1.46819646
25	PHKG1	1.40283248
26	PHKG2	1.40283248
27	CDC7	1.32358101
28	TEC	1.30918311
29	PAK3	1.21968708
30	NME2	1.18249998
31	INSRR	1.18247582
32	NME1	1.13857005
33	TRIM28	1.08860281
34	IKBKB	1.07660457
35	TSSK6	1.01975580
36	VRK1	1.00531174
37	MAP3K12	0.98984089
38	PLK3	0.97959690
39	PRKCG	0.95185036
40	MKNK1	0.92556508
41	RPS6KA5	0.92318236
42	ITK	0.92131269
43	TAF1	0.90677895
44	PASK	0.88665480
45	MAP4K1	0.86124584
46	PRKCQ	0.79304306
47	NTRK3	0.78177987
48	CASK	0.77476737
49	MAP3K4	0.77018404
50	LRRK2	0.76818909
51	TNK2	0.75084144
52	MKNK2	0.73971449
53	PLK4	0.72934680
54	EIF2AK1	0.71392483
55	BTK	0.70036340
56	PRKCE	0.68935298
57	CAMK1	0.68534528
58	ADRBK1	0.65788663
59	CSNK2A2	0.64518848
60	PLK2	0.64030603
61	FES	0.62740628
62	PNCK	0.62670129
63	MUSK	0.59521332
64	MYLK	0.56928702
65	MAPKAPK5	0.56537647
66	PRKACA	0.55772438
67	CSF1R	0.54307633
68	MINK1	0.53770643
69	PIK3CA	0.53395118
70	PLK1	0.52901245
71	AURKB	0.51778035
72	ATR	0.51730161
73	BCKDK	0.50980615
74	OBSCN	0.50658428
75	CSNK1E	0.50329887
76	CSNK2A1	0.48658583
77	CSNK1G2	0.48171979
78	ACVR1B	0.47772601
79	CSNK1A1	0.47049345
80	LIMK1	0.43954973
81	FLT3	0.43657095
82	EPHB2	0.42884386
83	DAPK3	0.42854723
84	TGFBR1	0.42809758
85	ALK	0.41578480
86	CSNK1G3	0.40907943
87	CAMK2D	0.39772890
88	SGK1	0.39753070
89	CSNK1G1	0.39669321
90	CAMK2A	0.39585390
91	PRKCA	0.38857405
92	ILK	0.36853630
93	PBK	0.36547300
94	LYN	0.35823991
95	RPS6KA6	0.35722197
96	MAPK13	0.35126171
97	SGK223	0.34022038
98	SGK494	0.34022038
99	KIT	0.33016300
100	PRKCI	0.32357563

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.61102788
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.00147334
3	Parkinsons disease_Homo sapiens_hsa05012	3.16677124
4	Protein export_Homo sapiens_hsa03060	3.09968237
5	Asthma_Homo sapiens_hsa05310	2.84021981
6	RNA polymerase_Homo sapiens_hsa03020	2.64146972
7	Proteasome_Homo sapiens_hsa03050	2.55543775
8	Alzheimers disease_Homo sapiens_hsa05010	2.15447694
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.14261324
10	Huntingtons disease_Homo sapiens_hsa05016	2.13938059
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.13713292
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.99264060
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.95859878
14	Allograft rejection_Homo sapiens_hsa05330	1.92765543
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.82420363
16	Homologous recombination_Homo sapiens_hsa03440	1.79693346
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.71422704
18	Phototransduction_Homo sapiens_hsa04744	1.71389810
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.70999555
20	Type I diabetes mellitus_Homo sapiens_hsa04940	1.67066139
21	RNA degradation_Homo sapiens_hsa03018	1.64472956
22	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.60566296
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.59928554
24	Basal transcription factors_Homo sapiens_hsa03022	1.51617041
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.43562064
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.41413596
27	One carbon pool by folate_Homo sapiens_hsa00670	1.35332520
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.30228934
29	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.29909651
30	Graft-versus-host disease_Homo sapiens_hsa05332	1.28609061
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.22523041
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.19459794
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.19133652
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.18521537
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.17092825
36	Caffeine metabolism_Homo sapiens_hsa00232	1.17088594
37	Mismatch repair_Homo sapiens_hsa03430	1.13251547
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.11880621
39	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.10033436
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07016458
41	Propanoate metabolism_Homo sapiens_hsa00640	1.04427155
42	Purine metabolism_Homo sapiens_hsa00230	1.01740575
43	Nicotine addiction_Homo sapiens_hsa05033	1.00270548
44	Nitrogen metabolism_Homo sapiens_hsa00910	0.98303267
45	Primary immunodeficiency_Homo sapiens_hsa05340	0.96336070
46	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.91545711
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.89954318
48	Butanoate metabolism_Homo sapiens_hsa00650	0.89737887
49	DNA replication_Homo sapiens_hsa03030	0.88382055
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.85181950
51	Sulfur metabolism_Homo sapiens_hsa00920	0.84736299
52	Peroxisome_Homo sapiens_hsa04146	0.84386741
53	Rheumatoid arthritis_Homo sapiens_hsa05323	0.82709822
54	RNA transport_Homo sapiens_hsa03013	0.81820046
55	Spliceosome_Homo sapiens_hsa03040	0.77876519
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.77323855
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.77112576
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75984734
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74135333
60	Regulation of autophagy_Homo sapiens_hsa04140	0.72869344
61	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.70568218
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.70362456
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.66633920
64	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.66488325
65	Metabolic pathways_Homo sapiens_hsa01100	0.66312399
66	Olfactory transduction_Homo sapiens_hsa04740	0.65951621
67	Morphine addiction_Homo sapiens_hsa05032	0.65366340
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63894063
69	Retinol metabolism_Homo sapiens_hsa00830	0.62265283
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60884955
71	Base excision repair_Homo sapiens_hsa03410	0.58453150
72	Insulin secretion_Homo sapiens_hsa04911	0.57031059
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56243516
74	Steroid biosynthesis_Homo sapiens_hsa00100	0.55897537
75	Sulfur relay system_Homo sapiens_hsa04122	0.55317324
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.53104505
77	GABAergic synapse_Homo sapiens_hsa04727	0.52570034
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52405998
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51751717
80	Serotonergic synapse_Homo sapiens_hsa04726	0.50943862
81	Fatty acid degradation_Homo sapiens_hsa00071	0.49449748
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.46658003
83	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.45464447
84	Mineral absorption_Homo sapiens_hsa04978	0.45100836
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.44929479
86	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.44632658
87	Glutathione metabolism_Homo sapiens_hsa00480	0.44057150
88	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.41409689
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.41351466
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41052588
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.37293147
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37209370
93	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.36719480
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.36289101
95	Fatty acid elongation_Homo sapiens_hsa00062	0.35956133
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34065106
97	Antigen processing and presentation_Homo sapiens_hsa04612	0.33468844
98	Non-homologous end-joining_Homo sapiens_hsa03450	0.32089427
99	Glutamatergic synapse_Homo sapiens_hsa04724	0.31617706
100	Taste transduction_Homo sapiens_hsa04742	0.30614084

RPL21P127

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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